Relevant bibliographies by topics / Rotaviral Replication

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  2. Dissertations / Theses
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Academic literature on the topic 'Rotaviral Replication'

Author: Grafiati
Published: 4 June 2021
Last updated: 7 September 2023

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Journal articles on the topic "Rotaviral Replication"

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Zhou, Yan, Linlin Chen, Jing Du, et al. "MicroRNA-7 Inhibits Rotavirus Replication by Targeting Viral NSP5 In Vivo and In Vitro." Viruses 12, no. 2 (2020): 209. http://dx.doi.org/10.3390/v12020209.

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Rotavirus (RV) is the major causes of severe diarrhea in infants and young children under five years of age. There are no effective drugs for the treatment of rotavirus in addition to preventive live attenuated vaccine. Recent evidence demonstrates that microRNAs (miRNAs) can affect RNA virus replication. However, the antiviral effect of miRNAs during rotavirus replication are largely unknown. Here, we determined that miR-7 is upregulated during RV replication and that it targets the RV NSP5 (Nonstructural protein 5). Results suggested that miR-7 affected viroplasm formation and inhibited RV r
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Cheung, Winsome, Michael Gill, Alessandro Esposito, et al. "Rotaviruses Associate with Cellular Lipid Droplet Components To Replicate in Viroplasms, and Compounds Disrupting or Blocking Lipid Droplets Inhibit Viroplasm Formation and Viral Replication." Journal of Virology 84, no. 13 (2010): 6782–98. http://dx.doi.org/10.1128/jvi.01757-09.

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ABSTRACT Rotaviruses are a major cause of acute gastroenteritis in children worldwide. Early stages of rotavirus assembly in infected cells occur in viroplasms. Confocal microscopy demonstrated that viroplasms associate with lipids and proteins (perilipin A, ADRP) characteristic of lipid droplets (LDs). LD-associated proteins were also found to colocalize with viroplasms containing a rotaviral NSP5-enhanced green fluorescent protein (EGFP) fusion protein and with viroplasm-like structures in uninfected cells coexpressing viral NSP2 and NSP5. Close spatial proximity of NSP5-EGFP and cellular pe
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Fenaux, M., M. A. Cuadras, N. Feng, M. Jaimes, and H. B. Greenberg. "Extraintestinal Spread and Replication of a Homologous EC Rotavirus Strain and a Heterologous Rhesus Rotavirus in BALB/c Mice." Journal of Virology 80, no. 11 (2006): 5219–32. http://dx.doi.org/10.1128/jvi.02664-05.

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ABSTRACT Although rotavirus infection has generally been felt to be restricted to the gastrointestinal tract, over the last two decades there have been sporadic reports of children with acute or fatal cases of rotavirus gastroenteritis testing positive for rotavirus antigen and/or nucleic acid in various extraintestinal locations such as serum, liver, kidney, bladder, testes, nasal secretions, cerebrospinal fluid, and the central nervous system. Recently, studies in animals and people have demonstrated that rotavirus antigenemia is a common event during natural infection. In this study, we ext
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Morris, Andrew P., and Mary K. Estes. "VIII. Pathological consequences of rotavirus infection and its enterotoxin." American Journal of Physiology-Gastrointestinal and Liver Physiology 281, no. 2 (2001): G303—G310. http://dx.doi.org/10.1152/ajpgi.2001.281.2.g303.

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Rotaviral infection in neonatal animals and young children leads to acute self-limiting diarrhea, but infected adults are mainly asymptomatic. Recently, significant in-roads have been made into our understanding of this disease: both viral infection and virally manufactured nonstructural protein (NSP)4 evoke intracellular Ca2+([Ca2+]i) mobilization in native and transformed gastrointestinal epithelial cells. In neonatal mouse pup mucosa models, [Ca2+]ielevation leads to age-dependent halide ion movement across the plasma membrane, transepithelial Cl−secretion, and, unlike many microbial entero
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Criglar, Jeanette M., Ramakrishnan Anish, Liya Hu, et al. "Phosphorylation cascade regulates the formation and maturation of rotaviral replication factories." Proceedings of the National Academy of Sciences 115, no. 51 (2018): E12015—E12023. http://dx.doi.org/10.1073/pnas.1717944115.

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The rotavirus (RV) genome is replicated and packaged into virus progeny in cytoplasmic inclusions called viroplasms, which require interactions between RV nonstructural proteins NSP2 and NSP5. How viroplasms form remains unknown. We previously found two forms of NSP2 in RV-infected cells: a cytoplasmically dispersed dNSP2, which interacts with hypophosphorylated NSP5; and a viroplasm-specific vNSP2, which interacts with hyperphosphorylated NSP5. Other studies report that CK1α, a ubiquitous cellular kinase, hyperphosphorylates NSP5, but requires NSP2 for reasons that are unclear. Here we show t
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Ramírez, María-Camila, Kelly Méndez, Alicia Castelblanco-Mora, Sandra Quijano, and Juan Ulloa. "In Vitro Evaluation of Anti-Rotaviral Activity and Intestinal Toxicity of a Phytotherapeutic Prototype of Achyrocline bogotensis (Kunth) DC." Viruses 14, no. 11 (2022): 2394. http://dx.doi.org/10.3390/v14112394.

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Viruses represent the primary etiologic agents (70–80%) of acute diarrheal disease (ADD), and rotavirus (RV) is the most relevant one. Currently, four rotavirus vaccines are available. However, these vaccines do not protect against emerging viral strains or are not available in low-income countries. To date, there are no approved drugs available against rotavirus infection. In this study, we evaluated the in vitro anti-rotaviral activity and intestinal toxicity of a phytotherapeutic prototype obtained from Achyrocline bogotensis (Kunth) DC. (PPAb); medicinal plant that contains compounds that
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Jafri, Mubeen, Bryan Donnelly, Monica McNeal, Richard Ward, and Greg Tiao. "MAPK signaling contributes to rotaviral-induced cholangiocyte injury and viral replication." Surgery 142, no. 2 (2007): 192–201. http://dx.doi.org/10.1016/j.surg.2007.03.008.

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Viskovska, M., R. Anish, L. Hu, et al. "Probing the Sites of Interactions of Rotaviral Proteins Involved in Replication." Journal of Virology 88, no. 21 (2014): 12866–81. http://dx.doi.org/10.1128/jvi.02251-14.

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Komoto, Satoshi, Saori Fukuda, Takayuki Murata, and Koki Taniguchi. "Human Rotavirus Reverse Genetics Systems to Study Viral Replication and Pathogenesis." Viruses 13, no. 9 (2021): 1791. http://dx.doi.org/10.3390/v13091791.

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Human rotaviruses (HuRVAs) are highly important causes of acute gastroenteritis in infants and young children worldwide. A lack of reliable and reproducible reverse genetics systems for HuRVAs has limited a proper understanding of HuRVA biology and also the rational design of live-attenuated vaccines. Since the development of the first reverse genetics system for RVAs (partially plasmid-based reverse genetics system) in 2006, there have been many efforts with the goal of generating infectious recombinant HuRVAs entirely from cloned cDNAs. However, the establishment of a HuRVA reverse genetics
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Montero, Hilda, Carlos F. Arias, and Susana Lopez. "Rotavirus Nonstructural Protein NSP3 Is Not Required for Viral Protein Synthesis." Journal of Virology 80, no. 18 (2006): 9031–38. http://dx.doi.org/10.1128/jvi.00437-06.

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ABSTRACT Initiation is the rate-limiting step in protein synthesis and therefore an important target for regulation. For the initiation of translation of most cellular mRNAs, the cap structure at the 5′ end is bound by the translation factor eukaryotic initiation factor 4E (eIF4E), while the poly(A) tail, at the 3′ end, is recognized by the poly(A)-binding protein (PABP). eIF4G is a scaffold protein that brings together eIF4E and PABP, causing the circularization of the mRNA that is thought to be important for an efficient initiation of translation. Early in infection, rotaviruses take over th
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Dissertations / Theses on the topic "Rotaviral Replication"

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FACCIOLO, Sabrina. "HSV-replication defective based vector as vaccines against Rotavirus infections." Doctoral thesis, Università degli studi di Ferrara, 2011. http://hdl.handle.net/11392/2388740.

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Background: Rotaviruses (RVs) are the most important cause of acute gastroenteritis in humans and animals. These viruses cause diarrheal disease primarily in the young, but infection and disease in older children and adults can occur, resulting in more than 600 000 deaths per annum, mainly in developing countries. RV particle is nonenveloped, with the viral genome of 11 segments of double-stranded RNA surrounded by three concentric protein layers: the outer layer is composed of VP (Viral Protein) 7 and VP4, the intermediate layer is formed by VP6, and the innermost layer is composed by VP2.
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Arnoldi, Francesca. "Interaction of rotavirus nonstructural protein NSP5 with the viral replication complex." Doctoral thesis, Scuola Normale Superiore, 2008. http://hdl.handle.net/11384/85952.

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Rotavirus morphogenesis starts in intracellular inclusion bodies called viroplasms, where synthesis of the11 dsRNA genome segments and their packaging in new viral particles take place. RNA replication is mediated by several viral proteins, of which VP1, the RNA-dependent RNA polymerase, and VP2, the core scaffolding protein, were shown to be sufficient to provide replicase activity in vitro. In vivo, however, viral replication complexes also contain the nonstructural proteins NSP2 and NSP5, which were shown to be essential for replication, to interact with each other and to form viropl
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Muszynski, Bartosz. "Structure Function Studies of Rotavirus NSP5." Doctoral thesis, Scuola Normale Superiore, 2008. http://hdl.handle.net/11384/85974.

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Rotaviruses, causative agents of gastroenteritis in young animals and humans, are large icosahedral viruses with a complex architecture. The double-stranded RNA (dsRNA) genome composed of 11 segments, that codes for 6 structural and 6 non-structural proteins, is enclosed within three concentric capsid layers. NSP5, a non structural protein, is encoded by segment 11. It is produced early in infection and localizes in ‘viroplasms’, cytoplasmic inclusion bodies in which viral RNA replication and packaging take place. NSP5 is essential for the replicative cycle of the virus since, in its ab
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Steger, Courtney Long. "Determinants of Core Shell Dependent Rotavirus Polymerase Activity." Diss., Virginia Tech, 2019. http://hdl.handle.net/10919/87755.

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Rotaviruses (RVs) are medically significant gastrointestinal pathogens and are a leading cause of childhood mortality in many countries. The RV RNA-dependent RNA polymerase, VP1, synthesizes RNA during viral replication only in the presence of another RV protein, VP2, which comprises the innermost core shell layer of the virion. Though these VP1-VP2 interactions are essential for RV replication, the mechanism by which the core shell regulates polymerase activity remains incompletely understood. Here, we sought to identify and characterize specific regions of both VP1 and VP2 that are requir
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Gonzalez, Ana Maria. "Studies of human rotavirus candidate non-replicating vaccines and innate immunity in a gnotobiotic pig model of human rotavirus disease." The Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=osu1172622915.

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González, Ana María. "Studies of human rotavirus candidate non-replicating vaccines and innate immunity in a gnotobiotic pig model of human rotavirus disease." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1172622915.

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Pollock, Louisa Elizabeth. "Predictors of vaccine virus replication, immune response and clinical protection following oral rotavirus vaccination in Malawian children." Thesis, University of Liverpool, 2018. http://livrepository.liverpool.ac.uk/3022905/.

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Background: Current rotavirus vaccines are least effective in low-income, high-burden countries. Reduced vaccine response is likely to be multifactorial. The aim of this thesis was to determine whether passively-acquired maternal antibody levels, oral polio vaccine (OPV) response and histo-blood group antigen (HBGA) phenotype predict vaccine virus replication, immune response and clinical protection in Malawian infants following oral administration of the monovalent human rotavirus vaccine (RV1). Methods: In a longitudinal cohort study, infants received two doses of RV1 at 6 and 10 weeks of ag
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THOUVENIN, ERIC. "Inhibition de la transcription du rotavirus par des anticorps monoclonaux anti-vp6. Utilisation de la cryomicoscopie electronique et de donnees de cristallographie par rayons x." Université Joseph Fourier (Grenoble), 2000. http://www.theses.fr/2000GRE10187.

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Les rotavirus sont l'une des causes majeures des gastro-enterites severes chez les enfants en bas ages. Ces virus appartiennent a la famille des reoviridae, ils sont d'allure spherique, non-enveloppes, possedent les symetries icosaedriques et leur genome est compose de 11 doubles brins d'arn (arndb). La capside de rotavirus est constituee de trois couches proteiques concentriques entourant le genome et deux enzymes virales vp1 et vp3. La couche externe se dissocie du virion lors de l'entree de celui-ci dans la cellule hote. La particule qui se retrouve dans le cytoplasme est alors appelee dlp
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Namsa, Nima Dondu. "Studies On Phosphorylation And Oligomerization Of Rotavirus Nonstructural Protein 5 (NSP5) And Cellular Pathways That Regulate Virus Replication." Thesis, 2012. https://etd.iisc.ac.in/handle/2005/2526.

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Rotavirus is one of the leading etiological agents of gastroenteritis in young of many species including humans worldwide and is responsible for about 600,000 infant deaths per annum. Rotavirus belongs to the Reoviridae family, and its genome is composed of 11 double-stranded RNA segments that encode six structural proteins and six nonstructural proteins. Rotavirus replication is fully cytoplasmic and occurs within highly specialized regions called viroplasms. NSP2 and NSP5 have been shown to be essential for viroplasm formation and, when co-expressed in uninfected cells, to form viroplasm¬lik
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Namsa, Nima Dondu. "Studies On Phosphorylation And Oligomerization Of Rotavirus Nonstructural Protein 5 (NSP5) And Cellular Pathways That Regulate Virus Replication." Thesis, 2012. http://etd.iisc.ernet.in/handle/2005/2526.

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Rotavirus is one of the leading etiological agents of gastroenteritis in young of many species including humans worldwide and is responsible for about 600,000 infant deaths per annum. Rotavirus belongs to the Reoviridae family, and its genome is composed of 11 double-stranded RNA segments that encode six structural proteins and six nonstructural proteins. Rotavirus replication is fully cytoplasmic and occurs within highly specialized regions called viroplasms. NSP2 and NSP5 have been shown to be essential for viroplasm formation and, when co-expressed in uninfected cells, to form viroplasm¬lik
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Books on the topic "Rotaviral Replication"

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Reoviruses: Entry, Assembly and Morphogenesis (Current Topics in Microbiology and Immunology). Springer, 2006.

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Roy, Polly. Reoviruses: Entry, Assembly and Morphogenesis. Springer, 2014.

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Book chapters on the topic "Rotaviral Replication"

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Patton, J. T. "Rotavirus Replication." In Current Topics in Microbiology and Immunology. Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-78256-5_5.

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Greenberg, Harry B., and Ann M. Arvin. "Live Attenuated Vaccines: Influenza, Rotavirus and Varicella Zoster Virus." In Replicating Vaccines. Springer Basel, 2010. http://dx.doi.org/10.1007/978-3-0346-0277-8_2.

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Patton, John T. "Rotavirus RNA Replication and Gene Expression." In Novartis Foundation Symposia. John Wiley & Sons, Ltd, 2008. http://dx.doi.org/10.1002/0470846534.ch5.

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Guglielmi, Kristen M., and John T. Patton. "Functions of the Rotavirus RNA Polymerase in Virus Replication." In National Institute of Allergy and Infectious Diseases, NIH. Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-512-5_4.

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Wentz, M. J., C. Q. Y. Zeng, J. T. Patton, M. K. Estes, and R. F. Ramig. "Identification of the minimal replicase and the minimal promoter of (—)-strand synthesis, functional in rotavirus RNA replication in vitro." In Viral Gastroenteritis. Springer Vienna, 1996. http://dx.doi.org/10.1007/978-3-7091-6553-9_7.

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Sen, Adrish, Siyuan Ding, and Harry B. Greenberg. "The Role of Innate Immunity in Regulating Rotavirus Replication, Pathogenesis, and Host Range Restriction and the Implications for Live Rotaviral Vaccine Development." In Mucosal Vaccines. Elsevier, 2020. http://dx.doi.org/10.1016/b978-0-12-811924-2.00041-9.

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Navarro, A., L. Williamson, M. Angel, and J. T. Patton. "Rotavirus Replication and Reverse Genetics." In Viral Gastroenteritis. Elsevier, 2016. http://dx.doi.org/10.1016/b978-0-12-802241-2.00007-9.

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Cheung, W., E. Gaunt, A. Lever, and U. Desselberger. "Rotavirus Replication: the Role of Lipid Droplets." In Viral Gastroenteritis. Elsevier, 2016. http://dx.doi.org/10.1016/b978-0-12-802241-2.00009-2.

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Patton, John T., Rodrigo Vasquez‐Del Carpio, M. Alejandra Tortorici, and Zenobia F. Taraporewala. "Coupling of Rotavirus Genome Replication and Capsid Assembly." In Advances in Virus Research. Elsevier, 2006. http://dx.doi.org/10.1016/s0065-3527(06)69004-0.

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Patton, John T., Karen Kearney, and Zenobia Taraporewala. "II, 4. Rotavirus genome replication: role of the RNA-binding proteins." In Perspectives in Medical Virology. Elsevier, 2003. http://dx.doi.org/10.1016/s0168-7069(03)09011-6.

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