Academic literature on the topic 'Routes of administration'

Qualitative research conducted in athletic training in the last two decades has increased but still lacks depth and breadth in pedagogy and education. This is especially evident in the multifaceted clinical education environment where diverse and alternat

Oxytetracycline (OTC) is one of two antibiotics currently available and approved by the U.S. Food and Drug Administration for use as a chemotherapeutic agent in food fish and is widely used in the aquaculture industry. Previous pharmacokinetic studies of OTC have been conducted in cold water and warm water species of fish. However, no pharmacokinetic studies have been conducted on a cool water species such as yellow perch (Perca flavescens). The yellow perch is a cool water game and commercial species with high aquaculture potential. The pharmacokinetic profiles of oxytetracycline (OTC) was determined by measuring plasma concentrations in yellow perch following intraperitoneal (i.p.), intramuscular (i.m.), per os (p.o.), and intracardiac (i.c.) administration at a single dose of 50 mg/kg body weight. Using a modification of a high-performance-liquid-chromatographic (HPLC) technique, the plasma OTC concentrations were determined for each of the four routes of administration. Plasma concentrations were also evaluated in yellow perch exposed to a static 48-hour OTC water bath (100 mg/l). The terminal half-lives (t1/2) of OTC in yellow perch for i.p., i.m., p.o., and i.c. administrations were 112, 124, 50, and 28 h, respectively. The t1/2 for the i.m. route of administration was significantly longer than in any of the published i.m. OTC fish studies to date. However, the times of maximum OTC concentration (tmax) for the i.p., i.m. and p.o. administrations (2, 4, and 15 h, respectively) occurred relatively early in the plasma concentration-time curves. This suggests, that in yellow perch, OTC is initially absorbed very rapidly. The area under the plasma concentration-time curves (AUC) for the i.p., i.m., p.o., and i.c. routes of administration were 1718, 2659, 383, and 134 mcg·h/ml, respectively. No OTC was detected in the plasma of yellow perch following the water bath route of exposure. Finally, in yellow perch, effective therapy (plasma OTC concentrations above MIC values for most bacteria pathogenic to fish â 4 mcg/ml) would be achieved for up to 168 hours following a single i.p. or i.m. injection of 50 mg/kg and for up to 15 hours following a single p.o dose of 50 mg/kg.<br>Master of Science

Bakalauro baigiamajame darbe atliekamas UAB „Volvina“ transporto logistikos veiklos vertinimas. Darbą sudaro dvi pagrindinės dalys. Pirmojoje dalyje apžvelgiama transporto logistika teoriniu aspektu: apibrėžiamos logistikos, jos sistemų ir transporto logistikos sampratos, pateikiama informacija apie maršrutų planavimą ir svarbą bei transporto įmonių veiklos efektyvumą. Antroje praktinėje darbo dalyje pateikiama UAB „Volvina“ charakteristika ir UAB „Volvina“ transporto logistikos vertinimas: transporto priemonių ir krovinių gabenimo paslaugos analizė bei maršrutų planavimo ir transportavimo procesų vertinimas. Darbo pabaigoje pateikiamos išvados ir rekomendacijos, kurios leidžia spręsti apie UAB „Volvina“ vykdomos veiklos efektyvumą ir siūlomus pokyčius gerinant įmonės darbo kokybę.<br>The Bachelor's paper performs an assessment of the transport logistics activity of the company Volvina, UAB. The paper consists of two parts. The first part provides an overview of the transport logistics in the theoretical aspect: defines the conceptions of logistics, its systems and transport logistics, provides the information about route planning and its importance and the efficiency of transport companies' performance. The second practical part of the paper presents the characteristic of the company Volvina, UAB and the assessment of transport logistics of the company Volvina, UAB: an analysis of vehicles and freight services, and the evaluation of route planning and transportation processes. At the end of the paper, we have presented the conclusions and recommendations that allow judging about the effectiveness of the activities performed by the company Volvina, UAB and the proposed changes on improvement of the company's performance. The aim of the research is to assess the transport logistics activities of the company Volvina, UAB.

<p>Can cross-border interaction: interpersonal, economic, and otherwise, help ease relations between neighbouring political entities facing conflicts of interest and other differences?</p><p>1. How and why are border crossing communication routes created and maintained?</p><p>2. Under what circumstances are they used and how?</p><p>3. In what ways do they alter the conditions of a conflict between the parties that they link?</p><p>4. How do governments relate to the communication route and in what ways do they fit it into their policies?</p><p>Seeking to reconcile the theories of the international system advanced by Hedley Bull and John W. Burton, we conduct a comparative case study, based on contemporary media and scholarship, of the situations regarding Senegal and the Gambia, as well as the two de facto (if not de jure) republics of Cyprus to answer these questions. Having sought to estimate the causes and effects of border crossing, we find that host factors, in particular divergent economies and the utilization of international partners, may in fact come to stem from the issues of border-crossing activity and contribute to complicating existing conflicts rather than resolve them.</p>

TRADUÃÃO DE INSTRUMENTO PARA AVALIAR A NÃO ADESÃO DAS MÃES AO TRATAMENTO DE SEUS FILHOS COM DOENÃAS CRÃNICAS E IDENTIFICAÃÃO DAS POSSÃVEIS DIFICULDADES QUE AS MÃES ENFRENTAM PARA OBTER E ADMINISTRAR MEDICAMENTOS AOS SEUS FILHOS NO DOMICÃLIO Autora: PatrÃcia Quirino da Costa. Orientador: Ãlvaro Jorge Madeiro Leite. Tese de doutorado em SaÃde Coletiva. Faculdade de Medicina. Universidade Federal do CearÃ,2012 Muitas crianÃas portadoras de doenÃas crÃnicas necessitam uso continuo de medicamentos para o controle da patologia. A adesÃo ao tratamento à um ponto crucial para se conseguir esse controle e diversos fatores tem sido identificados para a nÃo adesÃo em crianÃas, dentre estes a carÃncia de formulaÃÃes adequadas à faixa etÃria. O Beliefs and Behaviour Questionnaire avalia a nÃo adesÃo ao tratamento medicamentoso em adultos com doenÃa crÃnica. Apresenta 30 itens em 3 subseÃÃes: convicÃÃes, experiÃncias e comportamentos, e permite identificar fatores relacionados à nÃo adesÃo. Na crianÃa, o medicamento à administrado quase sempre por um cuidador, em geral a mÃe. O objetivo do trabalho foi adaptar culturalmente e validar o BBQ para avaliar a nÃo adesÃo das mÃes/cuidadores ao tratamento dos seus filhos com doenÃas crÃnicas, e conhecer em profundidade as dificuldades enfrentadas no tratamento domiciliar. Etapas da adaptaÃÃo: traduÃÃo, sÃntese das traduÃÃes e adaptaÃÃo cultural, retraduÃÃo, revisÃo tÃcnica, prÃ-teste. ValidaÃÃo feita pela AnÃlise dos Componentes Principais, aplicando o instrumento a 28 cuidadores de crianÃas portadoras de doenÃa crÃnica que estavam internadas em hospital estadual de referÃncia pediÃtrica, em Fortaleza, identificados sequencialmente; seguido-se visita domiciliar 30-40 dias pÃs-alta hospitalar. Aos mesmos cuidadores (acrescidos de dois) foi aplicado um questionÃrio semiestruturado onde se investigava as dificuldades encontradas na busca e administraÃÃo dos medicamentos prescritos na alta hospitalar. Os dados descritivos obtidos foram quantificados por estatÃsticas simples. As entrevistas foram gravadas, decupadas e analisadas qualitativamente com apoio na fenomenologia. O questionÃrio final BBQ-Br possui 24 itens divididos em 3 seÃÃes como no original; apresentou alta confiabilidade, verificada atravÃs da anÃlise da consistÃncia interna, e valores de alfa Cronbach elevados para todas as subseÃÃes. Os itens foram agrupados em cada seÃÃo como no artigo referÃncia e apresentaram elevada correlaÃÃo entre si, avaliada pelo teste de esfericidade de Bartlett. Participaram do estudo descritivo 30 cuidadores (26 mÃes, 2 pais, 1 tia e 1 avÃ), com grau de escolaridade predominante âensino fundamental incompletoâ e residÃncia em Ãreas pobres da cidade. Dos 25 cuidadores que buscaram medicamentos no SUS apenas 4 receberam todos os itens prescritos e 21 (70%) adquiriram algum medicamento em farmÃcias privadas. Principais dificuldades na administraÃÃo de medicamentos: sabor desagradÃvel, necessidade de partiÃÃo e dureza de comprimidos, ausÃncia de dispositivo dosador. EstratÃgias mais utilizadas: diluiÃÃo ou dissoluÃÃo em Ãgua com aÃÃcar; forÃar a deglutir. No estudo qualitativo foram identificadas dificuldades de compreensÃo das orientaÃÃes mÃdicas e na obtenÃÃo de medicamentos incluindo: desabastecimento das unidades de saÃde; medicamentos entregues fora da embalagem primÃria, sem bula, sem dispositivos para administraÃÃo e sem orientaÃÃo para o uso adequado. A mÃe procura cumprir a prescriÃÃo mÃdica, embora nÃo compreenda bem o seu significado, mas, diante das dificuldades toma decisÃes cujo alcance nÃo conhece, por exemplo, interromper um tratamento. A informaÃÃo adequada e facilidade de administraÃÃo sÃo fatores limitantes para que esse papel possa ser bem desempenhado. O questionÃrio BBQBr à potencialmente Ãtil para a identificar o potencial de nÃo adesÃo e os fatores envolvidos, fac

Made available in DSpace on 2014-06-11T19:32:56Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-04-29Bitstream added on 2014-06-13T19:43:48Z : No. of bitstreams: 1 steagall_pvm_dr_botfm.pdf: 393562 bytes, checksum: 5728f72f985284dda5f8f079a19a7e0a (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>O objetivo do estudo foi avaliar os efeitos antinociceptivos da buprenorfina em gatos, quando administrada em diferentes doses pela via intravenosa (IV), e também por diferentes vias de administração, por meio da mensuração do limiar nociceptivo térmico (LNT) e mecânico (LNM) num estudo cruzado, cego e aleatório. O estímulo nociceptivo térmico (LNT) foi realizado por meio de um dispositivo justaposto a um mangüito de pressão neonatal, posicionado ao redor do tórax do gato por uma cinta elástica. O estímulo nociceptivo mecânico foi realizado por meio de um bracelete de plástico, colocado ao redor do antebraço do gato. Na primeira fase, após as mensurações basais dos LNT e LNM, oito gatos (3,8±0,6kg) receberam buprenorfina (IV) nas doses de 0,01 (B1), 0,02 (B2) e 0,04 (B4) mg/kg. As mensurações foram feitas até 10h após cada tratamento. Na segunda fase, após as mensurações basais dos LNT, seis gatos (4,1±0,5kg) receberam buprenorfina (0,02 mg/kg) pelas vias IV, intramuscular (IM) e subcutânea (SC). As mensurações foram realizadas até 24h após cada tratamento. Na terceira fase, após as mensurações basais dos LNT e LNM, oito gatos (4,7±1,5kg) receberam buprenorfina (0,02 mg/kg) pela via epidural, por meio de uma via de acesso vascular implantada cirurgicamente antes do início do estudo. As mensurações foram realizadas até 24h após cada tratamento. Os dados foram analisados por ANOVA (P<0,05). Os LNT e LNM acima do intervalo de confiança de 95% (IC95%), gerados pelos valores basais, indicaram antinocicepção. Na primeira fase, os LNT e os LNM aumentaram significativamente entre 15min e 4h (LNT) após B1, entre 15min e 2h e aos 15 e 45min após B2, e entre 15min e 8h, exceto às 4h, e entre 30min e 2h, após B4, respectivamente. Aos 45min, os LNM foram significativamente maiores em B2 quando comparados a B1. As médias dos LNT e dos LNM ficaram...<br>The aim of this study was to evaluate the antinociceptive effects of buprenorphine in cats after intravenous (IV) administration of different doses and after different routes of administration, by means of measuring thermal (TT) and mechanical (MT) nociceptive thresholds, in a randomized, blinded and crossover study. Thermal stimulation was given via a probe, attached to an elasticated band and positioned around the cat’s thorax with an inflated modified neonatal cuff. Mechanical stimulation was given via a plastic bracelet with a modified neonatal cuff, taped around the cat’s antebrachium. In the first phase, after MT and TT baseline recordings, eight cats (3.8±0.6kg) were given 0.01 (B1), 0.02 (B2) and 0.04 (B4) mg/kg of buprenorphine IV. Thresholds were measured until 10h after administration of treatments. In the second phase, after TT baseline recordings, buprenorphine (0.02 mg/kg) was administered to six cats (4.1±0.5kg) by the IV, intramuscular (IM) and subcutaneous (SC) routes. Threshold measurements were performed up to 24h after treatments. In the third phase, after TT and MT baseline recordings, eight cats (4.7±1.5kg) received buprenorphine (0.02 mg/kg), through a vascular access port that had been surgically implanted in the epidural space. TT and MT were measured up to 24h after each treatment. Data were analyzed by ANOVA (P<0.05). A 95% confidence interval (IC95%) was generated by the baseline values. Thresholds above IC95% indicated antinociception. In the first phase, compared to baseline, TT were significantly increased between 15min and 4h after B1, between 15min and 2h after B2, and between 15min and 8h, expect at 4h, after B4. MT was significantly increased at 15 and 45min after B2 and between 30min and 2h after B4. At 45min, MT were significantly higher in B2 compared to B1. Mean TT were above the IC95% from 15min to 10h in all groups. Mean MT were... (Complete abstract click electronic access below)

Abstract Purpose: is to identify the challenges of multimodal transport service of ESLSE in the Europe trade routes operation from origin up to destination and to analyze the contribution of network partners to ESLSE solving these challenges.   Design\Data collection\Approach: This thesis relied on qualitative research design in order to identify the key challenges of multimodal transport services and to show how the network partners contribute to solving these challenges. Moreover, to achieve the objective of the study, semi structure interviews were used, and the responses from 14 experts were analyzed.   Theoretical framework: The theoretical base and concepts are used to determine the theoretical boundaries of the research. It provides an overview of the literature that exists in the challenges of multimodal transport services. The theoretical framework firstly encompassed the logistics performance and personnel, followed by the description of multimodal transport services, customs facilitation, ICT, infrastructure, network partner integration and port administration. Lastly, theoretical synthesis is developed that are identified from the theory to demonstrate the interrelationship between individual concepts.   Findings: The findings of this study revealed that multimodal transport service was impacted by a number of challenges even if the network partners contributed some solutions. The results of the study showed that the lack of skilled logistics personnel; poor ICT system; lack of integration between network partners; lack of effective infrastructure; inadequate and ineffective capacity of trucks; material theft; corruption; security risk; lack of prompt response in the operation between network partners; monopoly of the operation by ESLSE; and lack of quality of transported cargo are the main challenges for multimodal transport services. Managerial implication: For managers of network partners, it is recommended that they should be aware that the challenge of multimodal transport service is the result of poor ICT systems; lack of integration between network partners; lack of effective infrastructure; lack of skilled logistic personnel; inadequate and ineffective capacity of trucks; material theft; corruption; security risk; lack of quality of transported cargo; and lack of prompt response in the operation between the network partners Hence, they should take action to solve the problems by integrating with shipping agents and steering committees such as customers office, transport minister, and maritime authority. Moreover, the shipping agents managers can use the results of the study to enhance their contribution in order to solve the challenges of multimodal transport services by communicating with the ESLSE.   Limitations: The small sample size without adequately diverse geographical spread and sample of shipping agents and dry ports since the study is only limited to Europe trade routes and it did not take in to consideration other continents like Africa and Asia which could have given additional information on the topic. The sample of shipping agent and dry ports was limited with 3 out of 11 and 3 out of 7 respectively.   Originality\Value: This thesis is one of the first to analyze the challenges of multimodal transport in the case of Ethiopia to Europe trade operation by interviewing both the ESLSE and shipping agents.