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Journal articles on the topic "Rowan county (n.c.)"
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Wong, Yien Ning Sophia, Peter Sankey, Debra Hannah Josephs, Robert J. Jones, Simon J. Crabb, Sandy Beare, Marian Duggan, et al. "Nivolumab and ipilimumab treatment in prostate cancer with an immunogenic signature (NEPTUNES)." Journal of Clinical Oncology 37, no. 15_suppl (May 20, 2019): TPS5090. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.tps5090.
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TPS5090 Background: Responses to checkpoint inhibitor (CPI) monotherapy in patients with metastatic castration resistant prostate cancer (mCRPC) have been limited. This is in part attributed to low tumour mutational burden (TMB) and low tumour infiltrating lymphocytes (TILs). Previously ~20% patients with prostate cancer have demonstrated high TILs or TMB1. We hypothesize that patients with higher TMB due to mismatch repair deficiency (dMMR) or defective DNA damage response (dDDR) and patients with high TILs are more likely to respond to combination CPI with anti PD-1 and anti CTLA-4 therapy. Methods: NEPTUNES is a single arm phase II trial designed to assess the efficacy of nivolumab and ipilimumab in biomarker selected patients with mCRPC that have progressed following ≥1 line of therapy. The immunogenic signature (ImS) biomarker is defined by ≥1 of the following: 1) dMMR by immunohistochemistry (IHC); 2) dDDR detected by the UW-OncoPlex sequencing assay and; 3) high TILs on multiplexed IHC. The UW-OncoPlex assay detects mutations in >260 genes and provides an estimation of TMB. Assuming an ImS+ rate of 20%, we aim to pre-screen 175 patients in order to enrol 35 patients into the main study. The primary endpoint is composite response rate (CRR), achieved if ≥1 of the following criteria are satisfied: 1) radiological response by RECIST 1.1; 2) PSA response ≥50%; 3) conversion of circulating tumour cells (CTC) count from ≥5 cells at baseline to <5 cells at week 9. The treatment will be deemed ineffective if the CRR is <20%. Nivolumab (1 mg/kg) and ipilimumab (3 mg/kg) is dosed every three weeks for up to 4 times, followed by a 480mg flat dose of nivolumab every 4 weeks for up to one year. Baseline biopsies are mandated and paired biopsy at week 12 is encouraged. The secondary endpoints include safety, overall survival, and radiological and PSA progression free survival. Exploratory biological markers including TMB, mutational profiles, change in TILs and liquid biomarkers will be correlated with the primary clinical endpoint. Since opening in February 2018, 126 patients have been pre-screened with 25 ImS+. To date, 9/25 ImS+ patients have been enrolled into the main study. The trial is ongoing, with patient accrual expected to complete by late 2019. References: 1Linch, M., Goh, G., Hiley, C., Shanmugabavan, Y., McGranahan, N., Rowan, A., . . . Swanton, C. (2017). Intratumoural evolutionary landscape of high-risk prostate cancer: the PROGENY study of genomic and immune parameters. Ann Oncol, 28(10), 2472-2480. doi:10.1093/annonc/mdx355. Clinical trial information: NCT03061539.
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Hoff, Emily, Andrea E. Warden, Ruby Taylor, and Ank E. Nijhawan. "1064. Hepatitis C Epidemiology at the Dallas County Jail: A Changing Demographic." Open Forum Infectious Diseases 7, Supplement_1 (October 1, 2020): S560—S561. http://dx.doi.org/10.1093/ofid/ofaa439.1250.
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Abstract Background Nearly 1 in 3 people living with HCV pass through the CJ system each year. As a result, the CJ system is a crucial location for Hepatitis C screening, education and linkage to care. We aim to 1) identify the prevalence and incidence of HCV and 2) evaluate HCV demographic trends at a large urban jail. Methods Universal opt-out HCV testing was offered in four separate testing cycles from 2015 to 2019 to any individual undergoing a routine blood draw at the Dallas County Jail (N=14490; Figure 1). HCV antibody (Ab) assay (LabCorp) was used with reflex RNA testing added on in 2017. Demographic variables were extracted from the electronic medical record for all tested, with risk factors collected from those who tested positive for HCV Ab (HCV Ab+). Multivariate logistic regression was performed. Figure 1. HCV Ab and HCV RNA positivity among people screened for HCV in the Dallas County Jail from 2015 to 2019 (N=14490). Results The prevalence of HCV Ab+ was 16.7% in the Dallas County Jail; 75.3% of those who tested HCV Ab+ were also HCV RNA+ (Figure 1). The HCV Ab+ incidence rate was 13.5 cases per 1000 person-years. People who were HCV Ab+ were more frequently (adjusted odds ratio [95% confidence interval], p-value): older (1.07 (1.06-1.07), p< 0.001), female (1.24 [1.07-1.44], p=0.004), white (2.12 [1.83-2.45], p< 0.001), and in the birth cohort 1945-65 (1.79 [1.44-2.23], p< 0.001; Table 1). In earlier birth cohorts (1940s), black men were more often HCV Ab+; in more recent birth cohorts (1990s), white and Hispanic females were more often HCV Ab+ (Figure 2). Among individuals who tested HCV Ab+, IDU was more frequently reported by white individuals, particularly women, compared to black individuals (p< 0.001; Figure 3). Table 1. Demographic predictors of Hepatitis C Antibody positivity among those undergoing routine blood draws from 2015-19 at the Dallas County Jail (AIC 7041; BIC 7048; df 10; p<0.001). Figure 2. Trends of Hepatitis C Antibody prevalence and demographic prevalence ratios by birth year (prevalence ratio= proportion with disease/proportion with exposure) among people at the Dallas County Jail screened from 2017-2019 (N=10183). Demographic prevalence ratios were categorized by race (White, Hispanic, Black) and gender (Male, Female) into six categories. Gray bars represent the overall prevalence of HCV Ab+ by birth year. Figure 3. The racial demographics of injection drug use by gender among those who tested HCV Ab positive at the Dallas County Jail in 2017-2018 (n=672; total population p<0.001; male p=0.004; female p=0.008). Conclusion The high prevalence and incidence of HCV at the Dallas County Jail argues for routine, universal testing and linkage to treatment. Additionally, demographic trends mirror the IDU epidemic and have valuable implications for risk reduction and treatment interventions. Disclosures Ank E. Nijhawan, MD, MPH, Gilead (Grant/Research Support, Scientific Research Study Investigator, Research Grant or Support)
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Kuschel, G. "The Nearctic Nemonychidae (Coleoptera: Curculionoidea)." Insect Systematics & Evolution 20, no. 2 (1989): 121–71. http://dx.doi.org/10.1163/187631289x00276.
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AbstractThe Nemonychidae of the Nearctic Region are revised for the first time. The family is considered to contain the most primitive living weevil species, most of them associated with Araucariaceae, Podocarpaceae and Pinaceae, and spread over four biogeographical regions. The Nearctic fauna is composed of 17 species in five genera placed in two subfamilies, all associated with Pinaceae. The subfamily Rhinorhynchinae, here reported for the first time from the Nearctic, is represented by the new genus Atopomacer and its three species, all new - A. ites (type locality: Estes Park, Colorado), A. hoplites (type locality: Cerro Potosi, Nuevo León, Mexico), and A. orites (type locality: Cerro Potosí, Nuev León, Mexico). The nearest relatives seem to be those known to be associated with Podocarpaceae in New Zealand, Chile and Argentina. The subfamily Doydirhynchinae has 14 species in four genera. All species occur in the United States, and eight are also found in Canada. The only genus shared with the Palearctic is CimberisGozis, which has, apart from the type species C. attelaboides (Fabricius) from Europe, seven species in North America. These are C. bihirsuta Hatch, C. compta (LeConte), C. decipiens sp. n. (type locality: Mariposa County, California), C. elongata (LeConte), C. pallipennis (Blatchley), C. pilosa (LeConte), and C. turbans sp. n. (type locality: Wolverton, Sequoia National Park, California). Cimberis pallipennis is reinstated from synonymy with C. pilosa, and C. parvula Hatch is considered a junior synonym of C. compta. There are three new genera, Pityomacer with three new species - P carmelites (type locality: Carmel, Monterey County, California), P. nugax (type locality: Giant Forest, Tulare County, California), and P. pix (type locality: Vernon, British Columbia); Acromacer, with A. bombifrons (LeConte) transferred from Cimberis; and Lecontellus, proposed for the Nearctic species previously in the Palearctic genus Doydirhynchus Dejean, with the species L. byturoides (LeConte), L. pinicola sp. n. (type locality: W. Woffard Hts, Kern County, California), and L. slevini (Martin).
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Evans, Howard T. "Metamunirite, a new anhydrous sodium metavanadate from San Miguel County, Colorado." Mineralogical Magazine 55, no. 381 (December 1991): 509–13. http://dx.doi.org/10.1180/minmag.1991.055.381.02.
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AbstractMetamunirite, β-NaVO3, is found in cavities in sandstone in San Miguel County, Colorado, occurring as fine, fibrous, colourless needles. X-ray powder and precession photographs show the crystals to be orthorhombic, space group Pnma, with a = 14.134(7), b = 3.648(2), c = 5.357(2) Å. They are optically biaxial positive with nα = 1.780(2) (‖c), nβ = 1.800(2) (‖a), nγ ≫ 185 (‖b, fibre axis; positive elongation), 2Vz moderate. A crystal structure analysis, confirming the previously determined structure of β-NaVO3, shows the presence of (VO3)n chains made up of zig-zag VO5 square pyramids. Metamunirite is probably formed by dehydration of munirite, NaVO3.2H2O.
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Irving, Rachael, Vilma Charlton, Errol Morrison, Aldeam Facey, and Oral Buchanan. "Demographic Characteristics of World Class Jamaican Sprinters." Scientific World Journal 2013 (2013): 1–5. http://dx.doi.org/10.1155/2013/670217.
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The dominance of Jamaican sprinters in international meets remains largely unexplained. Proposed explanations include demographics and favorable physiological characteristics. The aim of this study was to analyze the demographic characteristics of world class Jamaican sprinters. Questionnaires administered to 120 members of the Jamaican national team and 125 controls elicited information on place of birth, language, ethnicity, and distance and method of travel to school. Athletes were divided into three groups based on athletic disciplines: sprint (s: 100–400 m;n=80), jump and throw (j/t: jump and throw;n=25) and, middle distance (md: 800–3000 m;n=15). Frequency differences between groups were assessed using chi-square tests. Regional or county distribution of sprint differed from that of middle distance (P<0.001) but not from that of jump and throw athletes (P=0.24) and that of controls (P=0.59). Sprint athletes predominately originated from the Surrey county (s = 46%, j/t = 37%, md = 17, C = 53%), whilst middle distance athletes exhibited excess from the Middlesex county (md = 60%). The language distribution of all groups showed uniformity with a predominance of English. A higher proportion of middle distance and jump and throw athletes walked to school (md = 80%, j/t = 52%, s = 10%, and C = 12%) and travelled greater distances to school. In conclusion, Jamaica’s success in sprinting may be related to environmental and social factors.
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INSULANDER, M., C. SILVERLÅS, M. LEBBAD, L. KARLSSON, J. G. MATTSSON, and B. SVENUNGSSON. "Molecular epidemiology and clinical manifestations of human cryptosporidiosis in Sweden." Epidemiology and Infection 141, no. 5 (August 9, 2012): 1009–20. http://dx.doi.org/10.1017/s0950268812001665.
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SUMMARYThis study describes the epidemiology and symptoms in 271 cryptosporidiosis patients in Stockholm County, Sweden. Species/genotypes were determined by polymerase chain reaction–restriction fragment-length polymorphism (PCR–RFLP) of theCryptosporidiumoocyst wall protein (COWP) and 18S rRNA genes. Species wereC. parvum(n=111),C. hominis(n=65),C. meleagridis(n=11),C. felis(n=2),Cryptosporidiumchipmunk genotype 1 (n=2), and a recently described species,C. viatorum(n=2). Analysis of the Gp60 gene revealed fiveC. hominisallele families (Ia, Ib, Id, Ie, If), and fourC. parvumallele families (IIa, IIc, IId, IIe). MostC. parvumcases (51%) were infected in Sweden, as opposed toC. hominiscases (26%). Clinical manifestations differed slightly by species. Diarrhoea lasted longer inC. parvumcases compared toC. hominisandC. meleagridiscases. At follow-up 25–36 months after disease onset, 15% of the patients still reported intermittent diarrhoea. In four outbreaks and 13 family clusters, a single subtype was identified, indicating a common infection source, which emphasizes the value of genotyping for epidemiological investigations.
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CANNIZZARO, ANDREW G., and THOMAS R. SAWICKI. "Two new species of the genus Crangonyx Bate, 1859 (Amphipoda: Crangonyctidae) from the St. Marks River Basin with notes on the “Crangonyx floridanus complex”." Zootaxa 4691, no. 4 (November 1, 2019): 301–32. http://dx.doi.org/10.11646/zootaxa.4691.4.1.
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Crangonyx ephemerus n. sp. and Crangonyx pseudoephemerus n. sp. are described from the headwaters of the St. Marks River in Leon County, Florida, based on detailed morphological and molecular comparisons with the closely related species Crangonyx floridanus Bousfield, 1963. The morphological and molecular data, including three species delimitation models, lend support to the hypothesis that the taxon C. floridanus sensu lato represents a species complex. Diagnostic morphological characteristics are highlighted and discussed within this group to assist in future morphological analyses.
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Hall, Linda M., Hugh J. Beckie, Ryan Low, Scott W. Shirriff, Robert E. Blackshaw, Nicole Kimmel, and Christoph Neeser. "Survey of glyphosate-resistant kochia (Kochia scoparia L. Schrad.) in Alberta." Canadian Journal of Plant Science 94, no. 1 (January 2014): 127–30. http://dx.doi.org/10.4141/cjps2013-204.
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Hall, L. M., Beckie, H. J., Low, R., Shirriff, S. W., Blackshaw, R. E., Kimmel, N. and Neeser, C. 2014. Survey of glyphosate-resistant kochia ( Kochia scoparia L. Schrad.) in Alberta. Can. J. Plant Sci. 94: 127–130. Glyphosate-resistant (GR) kochia was identified in Warner county in southern Alberta in 2011. To determine the scale of the distribution and frequency of GR kochia, a randomized stratified survey of more than 300 locations (one population per location) in southern Alberta was conducted in the fall of 2012. Mature plants were collected, seed separated, and F1 seedlings screened by spraying with glyphosate at 900 g a.e. ha−1 under greenhouse conditions. Screening confirmed 13 GR kochia sites: seven in Warner county, five in Vulcan county, and one in Taber county. The frequency of GR individuals in a population ranged from 0.3 to 98%. GR kochia were found in arid areas where chemical fallow is a significant component of the rotation. Economic and agronomic impact of this GR weed biotype is compounded because of multiple resistance to acetolactate synthase-inhibiting herbicides.
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von Bargen, S., T. Büttner, H. P. Mühlbach, J. Robel, and C. Büttner. "First Report of European mountain ash ringspot-associated virus in Sorbus aucuparia in Norway." Plant Disease 98, no. 5 (May 2014): 700. http://dx.doi.org/10.1094/pdis-09-13-0955-pdn.
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In July 2012, leaf mottle and intensive chlorotic ringspots were observed on urban, forest, or roadside mountain ash trees (Sorbus aucuparia L., rowan) of different ages in Norway during visual inspection of native broadleaf forest tree species. Symptoms resembled those caused by European mountain ash ringspot-associated virus (EMARaV), the type-member of the newly established genus Emaravirus, containing segmented ss(-)RNA and infecting woody host species (2). Leaves of nine out of 30 assessed rowan trees exhibiting characteristic symptoms were sampled in the counties of Nordland and Nord-Trøndelag (between 63.511806° and 66.304680°N latitude). Three of them were infested by the potential vector the eriophyid gall mite Phytoptus pyri. EMARaV was detected from total RNA extracts of leaves by reverse transcription-PCR using virus-specific primers amplifying 300 bp of RNA2 and 204 bp of RNA3, respectively (3). PCR fragments were directly sequenced from both ends and submitted to the EMBL database (accession nos. HG428680 to 97). Sequenced fragments comprising the partial gene encoding the glycoprotein-precursor (261 nucleotides of RNA2 omitting primer sequences) obtained from the nine sampled trees showed identities of 97 to 98% to the sequence of the reference strain of EMARaV from Hamburg, Germany (database accession AY563041). Comparison of 159 nucleotides of the 3′ untranslated region (3′ UTR) of viral RNA3 of the nine investigated rowans in Norway exhibited higher sequence diversity on nucleotide level (up to 50 nucleotide exchanges, or 31%) as previously reported from EMARaV variants from other European countries (4). When subjected to BLASTn search through GenBank, only three partial RNA3 sequences generated in this study showed sequence identities of 96% to the reference isolate (accession DQ831831). The other six sequences revealed only 68 to 73% identity to RNA3 sequences of EMARaV variants from GenBank. This led to formation of a separate cluster in phylogenetic analysis of partial RNA3 sequences of the six EMARaV variants from Norway when compared to previously characterized strains from the Czech Republic (n = 2), Finland (n = 17), Germany (n = 1), Great Britain (n = 5), Russia (n = 3), and Sweden (n = 10). From three Norwegian samples clustering separately in the tree based on the partial 3′ UTR of RNA3, the partial vRNA1 was amplified by RT-PCR using a generic primer set Motif-A-sense/Motif-C-antisense (1). Sequence analyses of these PCR fragments confirmed the viruses as members of the Emaravirus genus which were most closely related to EMARaV (data not shown). This is the first report of EMARaV in Norway infecting Sorbus aucuparia, a valuable native plant of northern Europe. The data obtained suggest a higher genetic variability of the EMARaV population in mountain ash trees in Norway than in other locations in Central and Northern Europe. However, whether the EMARaV variants identified in this study represent new strains of the virus have to be investigated in the future. References: (1) T. Elbeaino et al. J. Virol. Meth. 188:37, 2013. (2) N. Mielke-Ehret. and H. P. Mühlbach. Viruses 4:1515, 2012. (3) N. Mielke et al. For. Pathol. 38:371, 2008. (4) S. von Bargen et al. For. Pathol. 43: 429, 2013.
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Irimie, Marius. "Risk Factors and Aetiological Agents of Urethritis in Men with Urethritis in Brașov County." BULLETIN OF THE TRANSILVANIA UNIVERSITY OF BRASOV SERIES VI - MEDICAL SCIENCES 13 (62), no. 2 (December 30, 2020): 37–42. http://dx.doi.org/10.31926/but.ms.2020.62.13.2.5.
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"Introduction: Despite advances in the diagnosis and treatment of urethritis, they remain a global public health problem worldwide. Patients with urethritis have a higher risk sexual behavior than the general population. Aim: The aim of the study was to evaluate the risk factors and the etiological pathogens of urethritis in men among Brașov county. Patients and methods: A retrospective study was conducted in Medlife-PDR Clinic from Brașov, România, from Jan 2016 to Nov, 2020. 111 male patients aged from 17 to 78 years (mean age 34.5±10.26) presenting with dysuria, micturition discomfort and/or urethral discharge were included in the study. Results: The highest incidence of urethritis was among men aged 21-40 years. The acquisition of urethral infection was related to their young age, low educational level, multiple sexual partners and lack of condom use, most having extramarital relations including commercial sex. N. gonorrhoeae was identified as a causative agent in 18 (16.22%) patients with urethritis, C. trachomatis in 39 (35.14%) patients, Mycoplasma spp. in 5 (4.5%) patients, Ureaplasma spp. in 30 (27.03%) patients, Trichomonas vaginalis in 6 (5.4%) patients. A concurrent infection with N. gonorrhoeae and C. trachomatis was identified in one patient (0.01%). In 12 patients (9.9%) other infectious agents were identified and in one case the aetiological agent could not be identified (0.01%). Conclusion: By identifying risky sexual behaviors, clinicians may be able to provide educational counseling as well as assistance in the diagnosis and treatment of urethritis. "
Dissertations / Theses on the topic "Rowan county (n.c.)"
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Stormberg, Gregory J. "The Mist gas field, N.W. Oregon : source rock characterization and stable isotope (C,H,N) geochemistry." Thesis, 1991. http://hdl.handle.net/1957/37386.
Full textBooks on the topic "Rowan county (n.c.)"
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Hendricks, Garland A. Saints and sinners at Jersey Settlement: The life story of Jersey Baptist Church. [Charlotte, N.C: Delmar Co.], 1988.
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Pustola, Colleen A. Bower. The Bower/Winchcomb connection: Being a record of the descendants of Isaac N. Bower (1775 [i.e. 1776]-1844) of Chemung County, New York and James Winchcombe (c. 1710-?) of Wiltshire, England. [Lawton, Okla.]: C.A.B. Pustola, 1997.
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Montana. Dept. of Transportation. Environmental and Hazardous Waste Bureau. Reevaluation of the environmental assessment/finding of no significant impact for B-N overpass-Whitefish, RS 487-1(2)0, C# 0732: Construction of railroad overpass in Lincoln (i.e. Flathead) County. Helena?: The Dept., 1992.
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B, Alexander J. The History of Mecklenburg County, N C (#9778). Clearfield Co, 2002.
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Burke County, North Carolina Land Records, 1778 (Burke County, N. C., Land Records, 1778 Vol. 1). Southern Historical Press, Inc., 1985.
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Mceachern, Leora H. Duplin County, N. C. Court of Pleas And Quarter Sessions, 1784-1795: 1784-1787. Southern Historical Pr, 2005.
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Mceachern, Leora H. Duplin County, N. C. Court of Pleas and Quarter Sessions, 1792-1795: 1791-1795. Southern Historical Pr, 2005.
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