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Journal articles on the topic 'Royston Hospital'

Author: Grafiati

Published: 29 July 2024

Last updated: 31 July 2025

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1

Coid, Jeremy W. "A survey of patients from five health districts receiving special care in the private sector." Psychiatric Bulletin 15, no. 5 (1991): 257–62. http://dx.doi.org/10.1192/pb.15.5.257.

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There has been a rapid growth in the number of patients receiving secure and special care in private hospitals, although their overall numbers are still comparatively small. The behavioural modification unit at St Andrews Hospital, Northampton, has the largest concentration of detained patients outside the National Health Service (NHS), but there are plans to increase the number of beds at Kneesworth House, Royston, Herts, and Stockton Hall, Yorkshire. St Andrews Hospital has been run as a charitable trust but Kneesworth House and Stockton Hall are currently owned by a private French company,

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2

Sakowitz, Sara, Russyan Mark Mabeza, Syed Shahyan Bakhtiyar, et al. "Acute clinical and financial outcomes of esophagectomy at safety-net hospitals in the United States." PLOS ONE 18, no. 5 (2023): e0285502. http://dx.doi.org/10.1371/journal.pone.0285502.

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Background While safety-net hospitals (SNH) play a critical role in the care of underserved communities, they have been associated with inferior postoperative outcomes. This study evaluated the association of hospital safety-net status with clinical and financial outcomes following esophagectomy. Methods All adults (≥18 years) undergoing elective esophagectomy for benign and malignant gastroesophageal disease were identified in the 2010–2019 Nationwide Readmissions Database. Centers in the highest quartile for the proportion of uninsured/Medicaid patients were classified as SNH (others: non-SN

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Ghanem, Amr Sayed, Ágnes Tóth, Péter Takács, Battamir Ulambayar, Marianna Móré, and Attila Csaba Nagy. "Flexible Parametric Survival Modeling of Transaminases as Predictive Biomarkers for Non-Alcoholic Fatty Liver Disease: A Retrospective Longitudinal Study (2012–2022)." International Journal of Molecular Sciences 26, no. 11 (2025): 5057. https://doi.org/10.3390/ijms26115057.

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Non-alcoholic fatty liver disease (NAFLD) is a common metabolic liver disease linked to obesity and diabetes. This study aimed to assess whether serum GOT and GPT can predict NAFLD early in at-risk individuals. A retrospective cohort study was conducted using hospital records from the University of Debrecen (2012–2022), including 4886 NAFLD-free individuals at baseline. NAFLD incidence was tracked using ICD-10 codes, with transaminase levels (GOT and GPT) and key metabolic comorbidities analyzed as predictors in a longitudinal design. Survival analysis included Fleming–Harrington tests, Kaplan

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4

Pana, Tiberiu A., Adrian D. Wood, Jesus A. Perdomo-Lampignano, et al. "Impact of heart failure on stroke mortality and recurrence." Heart Asia 11, no. 1 (2019): e011139. http://dx.doi.org/10.1136/heartasia-2018-011139.

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ObjectiveWe aimed to examine the impact of heart failure (HF) on stroke mortality (in-hospital and postdischarge) and recurrence in a national stroke cohort from Thailand.MethodsWe used a large, insurance-based database including all stroke admissions in the public health sector in Thailand between 2004 and 2015. Logistic and Royston-Parmar regressions were used to quantify the effect of HF on in-hospital and long-term outcomes, respectively. All models were adjusted for age, sex and comorbidities and stratified by stroke type: acute ischaemic stroke (AIS) or intracerebral haemorrhage (ICH). M

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Ng, Ayesha P., Nikhil Chervu, Corynn Branche, et al. "National clinical and financial outcomes associated with acute kidney injury following esophagectomy for cancer." PLOS ONE 19, no. 3 (2024): e0300876. http://dx.doi.org/10.1371/journal.pone.0300876.

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Background Esophagectomy is a complex oncologic operation associated with high rates of postoperative complications. While respiratory and septic complications have been well-defined, the implications of acute kidney injury (AKI) remain unclear. Using a nationally representative database, we aimed to characterize the association of AKI with mortality, resource use, and 30-day readmission. Methods All adults undergoing elective esophagectomy with a diagnosis of esophageal or gastric cancer were identified in the 2010–2019 Nationwide Readmissions Database. Study cohorts were stratified based on

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Amrania, Hemmel. "Abstract P2-11-24: A Novel, Rapid and Economical Prognostic Tool For Adjuvant therapy Decisions in Hormone Positive Breast Cancer." Cancer Research 83, no. 5_Supplement (2023): P2–11–24—P2–11–24. http://dx.doi.org/10.1158/1538-7445.sabcs22-p2-11-24.

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Abstract Several multigene-based, risk scoring methods are available and their use is recommended to support treatment decision making in breast cancer. Although the value of these tests is established, critical challenges remain that limit their use, especially regarding turnaround time for fast decision making and the associated costs. We have developed DigiStain - a novel technology that uses mid-infrared imaging to precisely measure a surrogate of tumour aneuploidy, across unstained biopsy sections. Considering that genomic context shapes the pattern and consequences of aneuploidy during c

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7

Cámara Carrillo, Mónica Verenice, Santa Ramírez Godinez, and Juan Carlos Barrera de León. "Prevalencia de rechazo de injerto mediado por anticuerpos en pacientes pediátricos con trasplante renal." Revista de la Sociedad Ecuatoriana de Nefrología, Diálisis y Trasplante 10, no. 2 (2022): 108–14. http://dx.doi.org/10.56867/33.

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Introducción: El objetivo principal en el manejo de los pacientes receptores de trasplante renal, es mantener el estado de inmunosupresión adecuado para evitar la presentación de un rechazo inmunológico del injerto. El rechazo activo mediado por anticuerpos es una de las causas más frecuentes de disfunción del injerto en el periodo postrasplante temprano, además de representar una causa importante de disminución en su sobrevida, sin embargo, en México son escasos los reportes de la prevalencia de este evento, sobre todo en lo referente a la población pediátrica. Métodos: Estudio retrospectivo,

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8

Metts, Jonathan, Jonathan Hensel, Alejandro Alfaro, et al. "178 Expansion of Tumor-Infiltrating Lymphocytes and Marrow-Infiltrating Lymphocytes from Pediatric Malignant Solid Tumors." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (2021): A190. http://dx.doi.org/10.1136/jitc-2021-sitc2021.178.

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BackgroundHigh-risk non-CNS pediatric malignant solid tumors (pMST) have unsatisfactory outcomes, and novel therapies are warranted. Adoptive cellular therapy (ACT) using tumor-infiltrating lymphocytes (TIL) has produced durable responses in melanoma, and improvements in TIL expansion have made ACT-TIL feasible for other solid tumors.1–3 Preclinical mouse models suggest that T-cells from bone marrow (marrow-infiltrating lymphocytes, MIL) have antitumor reactivity offering another source for ACT.4 5 To demonstrate feasibility of ACT in pMST we hypothesized that TIL/MIL can be expanded from thes

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9

Pana, Tiberiu A., Mamas A. Mamas, Phyo K. Myint, and Dana K. Dawson. "Sex differences in myocardial infarction care and outcomes: a longitudinal Scottish National Data-Linkage Study." European Journal of Preventive Cardiology, November 27, 2024. http://dx.doi.org/10.1093/eurjpc/zwae333.

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Abstract Aims We investigate sex disparities in management and outcomes of myocardial infarction (MI) in contemporary practice in Scotland. Methods and results This was a longitudinal cohort study including all MI admissions aged 45-80 years across Scotland between 2010–2016 and 2:1 age, sex, and general practice-matched general population controls. Participants were followed up until the end of 2021. We analysed in-hospital outcomes (percutaneous coronary intervention, secondary prevention and mortality) using Poisson regressions, adjusting for age, comorbidities, and ST-elevation. We used Ro

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10

Hill, Micki, Paul C. Lambert, and Michael J. Crowther. "Relaxing the assumption of constant transition rates in a multi-state model in hospital epidemiology." BMC Medical Research Methodology 21, no. 1 (2021). http://dx.doi.org/10.1186/s12874-020-01192-8.

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Abstract Background Multi-state models are being increasingly used to capture complex disease pathways. The convenient formula of the exponential multi-state model can facilitate a quick and accessible understanding of the data. However, assuming time constant transition rates is not always plausible. On the other hand, obtaining predictions from a fitted model with time-dependent transitions can be challenging. One proposed solution is to utilise a general simulation algorithm to calculate predictions from a fitted multi-state model. Methods Predictions obtained from an exponential multi-stat

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Zaccardi, Francesco, Suping Ling, Karen Brown, Melanie Davies, and Kamlesh Khunti. "Duration of Type 2 Diabetes and Incidence of Cancer: An Observational Study in England." Diabetes Care, August 28, 2023. http://dx.doi.org/10.2337/dc23-1013.

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OBJECTIVE To investigate the association between duration of type 2 diabetes and cancer incidence. RESEARCH DESIGN AND METHODS In the Clinical Practice Research Datalink database, we identified 130,764 individuals with type 2 diabetes aged ≥35 years at diagnosis who were linked to hospital and mortality records. We used sex-stratified Royston–Parmar models with two time scales to estimate incidence rates of all cancers, the four commonest cancers in the United Kingdom (colorectal, lung, prostate, breast), and the obesity-related cancers (e.g., liver, ovary) between 1 January 1998 and 14 Januar

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12

Pana, T., M. A. Mamas, P. K. Myint, and D. Dawson. "Sex differences in secondary prevention and outcomes post-myocardial infarction in Scotland." European Heart Journal 45, Supplement_1 (2024). http://dx.doi.org/10.1093/eurheartj/ehae666.2781.

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Abstract Background Sex differences in outcomes after myocardial infarction (MI) are of increasing interest. Differential receipt of evidence-based treatments may contribute to such disparities. Purpose In this study, we investigate sex differences in the burden of risk factors, in-hospital and long-term treatment and outcomes in contemporary practice in Scotland, by analysing a nationwide sample of consecutive MI admissions. Methods All MI admissions centrally recorded between 2010-2016 by Public Health Scotland were included and followed up until the end of 2021. Poisson regressions analysed

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13

Muhammad-Kamal, H., B. Iyen, and S. Weng. "Developing and validating a prognostic model for mortality in patients with heart failure." European Heart Journal 43, Supplement_2 (2022). http://dx.doi.org/10.1093/eurheartj/ehac544.872.

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Abstract Background Heart Failure (HF) constitutes a major public health problem which remains highly prevalent in the UK and globally. Primary care plays a role in the long-term management of patients with heart failure but there are no clinically useful prognostic models to guide primary care professionals in determining those at increased risk of mortality, who could benefit from appropriate advanced care planning or escalation of treatment. Several predictive models exist but due to several limitations, clinical utility of these in the UK are limited. Purpose This study developed and valid

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14

Kerwagen, F., S. Sehner, J. Albert, et al. "Sex and marital status modify the effect of remote patient management on mortality risk in patients hospitalized for acute systolic heart failure: Insights from the E-INH study." European Heart Journal 44, Supplement_2 (2023). http://dx.doi.org/10.1093/eurheartj/ehad655.1063.

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Abstract Background The multitude of sex-specific effects and the prognostic relevance of marital status in patients with heart failure (HF) are well established. While the remote patient management (RPM) approach deployed in the Extended Interdisciplinary Network Heart Failure (E-INH) trial did not reduce the primary endpoint of time to all-cause death or rehospitalization (composite), questions remain regarding whether the effect of RPM might vary across subgroups of sex and marital status. Purpose To investigate the impact of sex and marital status on the effect of RPM in the E-INH trial. M

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15

Isenberg, Erin E., Joshua Sinamo, Michael A. Rubyan, Annie Ehlers, and Dana A. Telem. "Recurrent emergent hernia repairs: who is at risk?" Surgical Endoscopy, June 19, 2025. https://doi.org/10.1007/s00464-025-11914-y.

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Abstract Background Patients undergoing recurrent emergent hernia repairs may represent some of the most vulnerable patients in the healthcare system. However, this population has not been adequately characterized to date, limiting identification of opportunities for intervention. Methods We conducted a retrospective cross-sectional study of Medicare beneficiaries who underwent an index emergent or urgent ventral hernia repair between 2011 and 2021. We performed a multivariable risk-adjusted Royston–Parmar survival analysis for cumulative recurrent emergent hernia repair incidence within 10 ye

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16

Taylor, Stuart A., Shankar Kumar, Thomas Parry, et al. "Magnetic resonance enterography to predict subsequent disabling Crohn’s disease in newly diagnosed patients (METRIC-EF)—multivariable prediction model, multicentre diagnostic inception cohort." European Radiology, May 14, 2025. https://doi.org/10.1007/s00330-025-11636-8.

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Abstract Objectives Magnetic resonance enterography (MRE) is a first-line investigation to diagnose Crohn’s disease (CD), but its role for prognostication is unknown. Accordingly, we assessed the predictive ability of prognostic models including MRE scores (MRE Global Score (MEGS), simplified MR Index of Activity (sMARIA), and Lémann index (LI)) against models using clinical predictors alone for the development of modified Beaugerie disabling CD (MBDD) within 5 years of diagnosis. Methods This was a multicentre, diagnostic inception cohort of patients with newly diagnosed CD across 9 UK hospit

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