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Journal articles on the topic 'RRM'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Kotha, Sambasivarao, Milind Meshram, Priti Khedkar, Shaibal Banerjee, and Deepak Deodhar. "Recent applications of ring-rearrangement metathesis in organic synthesis." Beilstein Journal of Organic Chemistry 11 (October 7, 2015): 1833–64. http://dx.doi.org/10.3762/bjoc.11.199.

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Ring-rearrangement metathesis (RRM) involves multiple metathesis processes such as ring-opening metathesis (ROM)/ring-closing metathesis (RCM) in a one-pot operation to generate complex targets. RRM delivers complex frameworks that are difficult to assemble by conventional methods. The noteworthy point about this type of protocol is multi-bond formation and it is an atom economic process. In this review, we have covered literature that appeared during the last seven years (2008–2014).

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Roscales, Silvia, and Joaquín Plumet. "Ring Rearrangement Metathesis in 7-Oxabicyclo[2.2.1]heptene (7-Oxanorbornene) Derivatives. Some Applications in Natural Product Chemistry." Natural Product Communications 12, no. 5 (2017): 1934578X1701200. http://dx.doi.org/10.1177/1934578x1701200517.

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Metathesis reactions is firmly established as a valuable synthetic tool in organic chemistry, clearly comparable with the venerable Diels-Alder and Wittig reactions and, more recently, with the metal-catalyzed cross-coupling reactions. Metathesis reactions can be considered as a fascinating synthetic methodology, allowing different variants regarding substrate (alkene and alkyne metathesis) and type of metathetical reactions. On the other hand, tandem metathesis reactions such Ring Rearrangement Metathesis (RRM) and the coupling of metathesis reaction with other reactions of alkenes such as Di

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3

Wang, D. H., A. Yao, H. Zhao, and D. J. DiPette. "Regulation of ANG II receptor in hypertension: role of ANG II." American Journal of Physiology-Heart and Circulatory Physiology 271, no. 1 (1996): H120—H125. http://dx.doi.org/10.1152/ajpheart.1996.271.1.h120.

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To investigate the role of angiotensin II (ANG II) in the development of hypertension induced by reduced renal mass (RRM) and the gene expression of ANG II type 1 (AT1) receptors in the remnant renal tissue, four groups of rats were given 1% NaCl in water and subjected to RRM, RRM+ ramipril, RRM+ losartan, or sham surgery (control). Tail-cuff systolic blood pressure was significantly higher in RRM rats than in the other three groups. Northern blot showed that AT1 gene expression was significantly decreased in RRM, RRM + ramipril, or RRM + losartan vs. control. There was no significant differen

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4

Heemskerk-Gerritsen, Bernadette Anna Maria, Maartje Hooning, Christi J. van Asperen, et al. "Efficacy of risk-reducing mastectomy (RRM) on overall survival (OS) in BRCA1/2-associated breast cancer (BC) patients." Journal of Clinical Oncology 31, no. 15_suppl (2013): 1502. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.1502.

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1502 Background: RRM in BRCA1/2 mutation carriers with a history of unilateral BC significantly reduces the risk of developing contralateral BC (CBC). However, the outcome regarding OS is insufficiently known. Methods: The efficacy of RRM on CBC incidence and OS was studied in a Dutch multicenter cohort consisting of 515 BRCA-associated BC patients (399 BRCA1, 116 BRCA2) of whom 177 BRCA1 and 48 BRCA2 carriers underwent RRM. Data on patient, tumor and treatment characteristics were collected up to June 30, 2012. Women contributed person-years of observation (PYO) to the Non-RRM group from the

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5

Yamauchi, Hideko, Chizuko Nakagawa, Makoto Kobayashi, et al. "Cost-effectiveness of surveillance and prevention strategies in BRCA 1/2 mutation carriers." Journal of Clinical Oncology 35, no. 15_suppl (2017): e13051-e13051. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e13051.

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e13051 Background: Cost-effectiveness analysis is important in healthcare, especially in Japan, where preventive measures for carriers of BRCA 1/2 mutations are not covered by health insurance. Methods: We developed Markov models in a simulated cohort of women aged 35–70, and compared outcomes of surveillance with risk-reducing mastectomy at age 35 (RRM), risk-reducing salpingo-oophorectomy at age 45 (RRSO), and both (RRM&RRSO), with quality adjustment. We used breast and ovarian cancer incidence, and adverse event rates from previous studies, adjuvant chemotherapy and hormonal therapy rat

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Danpukdee, Tummaporn, Natsinee Athinartrattanapong, Phanorn Chalermdamrichai, et al. "Efficacy of Reusable Rubber Moulage on Mannequin Versus Conventional Method for Burn Size Estimation." Ramathibodi Medical Journal 47, no. 2 (2024): 12–20. http://dx.doi.org/10.33165/rmj.2024.47.2.266672.

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Background: Burn size estimation is crucial to burn fluid resuscitation. Therefore, training and practice to improve the accuracy of burn size estimation is important. Using reusable rubber moulage (RRM), the newly developed equipment to cooperating with simulation might help improve the accuracy of burn size estimation compared to conventional picture illustration. Objectives: To compare the accuracy of burn size estimation in simulation between picture illustration and RRM application, and to validate the face and content validity of RRM. Methods: Medical students, ER residents, EP staff, an

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Petsch, Ilona, and Boris Buerke. "Implementing the Radiology Rotation-Model-22 in Clerkships: The RRM-Pocket Card for Medical Students – Part 2." European Journal of Teaching and Education 6, no. 2 (2024): 1–11. http://dx.doi.org/10.33422/ejte.v6i2.1208.

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Practical training for medical students in radiology clerkships takes place in busy clinical routine. We introduced the Radiology Rotation-Model-22 (RRM) as the department-related RRM-pocket card for student rotation (SR) settings in part one of this study. RRM was developed as a documentation tool and pocket card with department sections for radiology (10) and imaging specialties (1) for medical students in clerkships. With the RRM-tool, and while exploring departments for practical experience, students can log data details on rotations and tasks by the method of participant observation (PO).

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8

Teixeira, B. B., R. R. Mota, R. B. Lôbo, et al. "Genetic evaluation of growth traits in Nellore cattle through multi-trait and random regression models." Czech Journal of Animal Science 63, No. 6 (2018): 212–21. http://dx.doi.org/10.17221/21/2017-cjas.

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We aimed to evaluate different orders of fixed and random effects in random regression models (RRM) based on Legendre orthogonal polynomials as well as to verify the feasibility of these models to describe growth curves in Nellore cattle. The proposed RRM were also compared to multi-trait models (MTM). Variance components and genetic parameters estimates were performed via REML for all models. Twelve RRM were compared through Akaike (AIC) and Bayesian (BIC) information criteria. The model of order three for the fixed curve and four for all random effects (direct genetic, maternal genetic, perm

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9

Yamada, K., A. Goto, C. Hui, et al. "Role of ouabainlike compound in rats with reduced renal mass-saline hypertension." American Journal of Physiology-Heart and Circulatory Physiology 266, no. 4 (1994): H1357—H1362. http://dx.doi.org/10.1152/ajpheart.1994.266.4.h1357.

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Ouabainlike compound (OLC) has recently been identified as a likely mammalian endogenous digitalis-like factor (EDLF) from human plasma. In this study, plasma levels of OLC were determined to assess the role of OLC in a model known as volume-expanded, reduced renal mass (RRM)-saline (S) hypertension in rats with use of a newly developed radioimmunoassay for ouabain. In the first experiment, at 3 wk after subtotal nephrectomy and drinking 1% saline solution, sysolic blood pressure (SBP) of 18 rats with reduced renal mass (RRM-S rats) was significantly higher than in 17 sham-operated saline-drin

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10

Kashyap, Maruthi, Akshay Kumar Ganguly, and Neel Sarovar Bhavesh. "Sequence-specific resonance assignments of human TAF15-RRM and TAF15-RRM-RanBP2." Biomolecular NMR Assignments 9, no. 1 (2014): 103–6. http://dx.doi.org/10.1007/s12104-014-9553-3.

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11

Liu, Zhizhen, Hong Chen, Yan Li, and Qi Zhang. "Taxi Demand Prediction Based on a Combination Forecasting Model in Hotspots." Journal of Advanced Transportation 2020 (July 21, 2020): 1–13. http://dx.doi.org/10.1155/2020/1302586.

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Accurate taxi demand prediction can solve the congestion problem caused by the supply-demand imbalance. However, most taxi demand studies are based on historical taxi trajectory data. In this study, we detected hotspots and proposed three methods to predict the taxi demand in hotspots. Next, we compared the predictive effect of the random forest model (RFM), ridge regression model (RRM), and combination forecasting model (CFM). Thereafter, we considered environmental and meteorological factors to predict the taxi demand in hotspots. Finally, the importance of indicators was analyzed, and the e

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Saho, Kenshi. "Steady-State Performance Analysis of Tracking Filter Using LFM Waveforms and Range-Rate Measurement." Mathematical Problems in Engineering 2018 (December 4, 2018): 1–10. http://dx.doi.org/10.1155/2018/9487581.

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The steady-state performance of a moving-object tracking filter is theoretically analyzed, assuming the simultaneous measurement of the range and range-rate (RRM system), and the use of linear frequency modulated (LFM) waveforms (RRM-LFM filter). An efficient analytical steady-state performance index, called an RMS index, is derived for the RRM-LFM filter to clarify the steady-state range prediction errors, theoretically. Using the derived RMS index, the optimal performance of the RRM-LFM filter is analyzed. The performance variation due to the use of LFM waveforms is clarified for the RRM tra

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Kralovicova, Jana, Ivana Borovska, Monika Kubickova, Peter J. Lukavsky, and Igor Vorechovsky. "Cancer-Associated Substitutions in RNA Recognition Motifs of PUF60 and U2AF65 Reveal Residues Required for Correct Folding and 3′ Splice-Site Selection." Cancers 12, no. 7 (2020): 1865. http://dx.doi.org/10.3390/cancers12071865.

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U2AF65 (U2AF2) and PUF60 (PUF60) are splicing factors important for recruitment of the U2 small nuclear ribonucleoprotein to lariat branch points and selection of 3′ splice sites (3′ss). Both proteins preferentially bind uridine-rich sequences upstream of 3′ss via their RNA recognition motifs (RRMs). Here, we examined 36 RRM substitutions reported in cancer patients to identify variants that alter 3′ss selection, RNA binding and protein properties. Employing PUF60- and U2AF65-dependent 3′ss previously identified by RNA-seq of depleted cells, we found that 43% (10/23) and 15% (2/13) of independ

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14

Lombard, Julian H., Jefferson C. Frisbee, Andrew S. Greene, Antal G. Hudetz, Richard J. Roman, and Peter J. Tonellato. "Microvascular flow and tissue Po 2 in skeletal muscle of chronic reduced renal mass hypertensive rats." American Journal of Physiology-Heart and Circulatory Physiology 279, no. 5 (2000): H2295—H2302. http://dx.doi.org/10.1152/ajpheart.2000.279.5.h2295.

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This study determined whether arteriolar blood flow, capillary red blood cell (RBC) velocity, capillary hematocrit (Hctcap), and tissue Po 2 are altered in cremaster muscles of rats with chronic reduced renal mass hypertension (RRM-HT) relative to normotensive rats on high- or low-salt (NT-HS vs. NT-LS) diet. The blood flow in first- through third-order arterioles was not different between NT and HT rats, either at rest or during maximal relaxation of the vessels with 10−4 M adenosine. Capillary RBC velocity was similar between the groups at rest but was elevated in RRM-HT and NT-HS rats durin

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15

De Gaudenzi, Javier, Alberto C. Frasch, and Christine Clayton. "RNA-Binding Domain Proteins in Kinetoplastids: a Comparative Analysis." Eukaryotic Cell 4, no. 12 (2005): 2106–14. http://dx.doi.org/10.1128/ec.4.12.2106-2114.2005.

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ABSTRACT RNA-binding proteins are important in many aspects of RNA processing, function, and destruction. One class of such proteins contains the RNA recognition motif (RRM), which consists of about 90 amino acid residues, including the canonical RNP1 octapeptide: (K/R)G(F/Y)(G/A)FVX(F/Y). We used a variety of homology searches to classify all of the RRM proteins of the three kinetoplastids Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major. All three organisms have similar sets of RRM-containing protein orthologues, suggesting common posttranscriptional processing and regulatory path

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16

Roca-Martínez, Joel, Hrishikesh Dhondge, Michael Sattler, and Wim F. Vranken. "Deciphering the RRM-RNA recognition code: A computational analysis." PLOS Computational Biology 19, no. 1 (2023): e1010859. http://dx.doi.org/10.1371/journal.pcbi.1010859.

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RNA recognition motifs (RRM) are the most prevalent class of RNA binding domains in eukaryotes. Their RNA binding preferences have been investigated for almost two decades, and even though some RRM domains are now very well described, their RNA recognition code has remained elusive. An increasing number of experimental structures of RRM-RNA complexes has become available in recent years. Here, we perform an in-depth computational analysis to derive an RNA recognition code for canonical RRMs. We present and validate a computational scoring method to estimate the binding between an RRM and a sin

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17

Prakash, V., A. K. Gupta, A. Gupta, R. S. Gandhi, A. Singh, and A. K. Chakravarty. "Random regression model with heterogeneous residual variance reduces polynomial order fitted for permanent environmental effect but does not affect genetic parameters for milk production in Sahiwal cattle." Animal Production Science 57, no. 6 (2017): 1022. http://dx.doi.org/10.1071/an15347.

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The random regression test-day models can accelerate the genetic improvement of Sahiwal cattle as test-day milk yield models offer a faster, accurate and economical approach of genetic evaluation. First three lactation monthly test-day records of Sahiwal cows calved between 1961 and 2012 at ICAR-National Dairy Research Institute, Karnal were used to fit random regression model (RRM) with various order of legendre polynomial, and a constant (RRM-HOM) or heterogeneous residual variance (RRM-HET). For both RRM-HOM and RRM-HET third order legendre polynomial for modelling additive genetic effects

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18

Hernandez, I., and A. S. Greene. "Hemodynamic and microcirculatory changes during development of renal hypertension." American Journal of Physiology-Heart and Circulatory Physiology 268, no. 1 (1995): H33—H38. http://dx.doi.org/10.1152/ajpheart.1995.268.1.h33.

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To study the progression of vessel loss (rarefaction) during the development of hypertension, a plastic window was chronically implanted over the biceps femoralis muscle of reduced renal mass (RRM) and sham-operated control (SOC) rats on a low-salt diet (0.4%). Blood pressure was measured directly via a catheter implanted in the femoral artery, and tissue blood flow was measured by laser-Doppler flowmetry before and after local topical application of sodium nitroprusside. Measurements were made on the control day and after an increase in sodium intake (4.0%) in RRM rats on days 5, 10, 14, 21,

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Sanchez-Forgach, E. R., C. Sanchez Basurto, and P. Zabalaga. "Contralateral risk-reducing (prophylactic) mastectomy (RRM) in patients (pts) with breast cancer (BC): Experience at Mastologica Lomas Breast Center in Mexico City." Journal of Clinical Oncology 29, no. 27_suppl (2011): 236. http://dx.doi.org/10.1200/jco.2011.29.27_suppl.236.

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236 Background: Contralateral RRM has increased in frequency due to patient (pt) and/or physician preference. We explore efficacy and satisfaction of procedure at our institution. Methods: A retrospective review of RRM performed from 2002 to 2010. Age, stage, BC subtype, timing of procedure, RRM pathology, reconstruction technique, complications, delay in systemic therapy, satisfaction index, and pt status were compared to pts. who did not undergo RRM. Results: 27 pts with BC had a contralateral RRM. Mean age was 34 (range 24-61). High-risk factors in 11 (40.75%) pts. Histology of BC breasts i

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Cotner, Cody, Susan Hilton, Ronac Mamtani, Thomas J. Guzzo, and David J. Vaughn. "Surveillance of postchemotherapy subcentimeter residual retroperitoneal mass (RRM) in metastatic nonseminomatous germ cell tumor (mNSGCT)." Journal of Clinical Oncology 38, no. 6_suppl (2020): 391. http://dx.doi.org/10.1200/jco.2020.38.6_suppl.391.

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391 Background: Approximately 30 – 60% of patients with mNSGCT treated with cisplatin-based chemotherapy (CBCT) achieve a complete response (CR), defined as normalization of serum tumor markers with either no RRM or a RRM < 1 cm. While there is universal agreement that patients with a RRM ≥ 1 cm should undergo retroperitoneal lymph node dissection (RPLND), many institutions, including ours, recommend surveillance for patients who achieve a CR. However, studies have not defined which axis of the RRM should be considered when making this decision. Methods: The electronic medical records (2007

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Meade, Adam W., Gabriel Pappalardo, Phillip W. Braddy, and John W. Fleenor. "Rapid Response Measurement: Development of a Faking-Resistant Assessment Method for Personality." Organizational Research Methods 23, no. 1 (2018): 181–207. http://dx.doi.org/10.1177/1094428118795295.

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While rating-scale-based assessments have been shown to be useful for measuring a variety of workplace-relevant constructs, assessment length and response distortion present practical limitations on their use. We describe a new type of measurement method termed rapid response measurement (RRM) in which stimuli are presented on a computer screen one at a time in rapid succession and respondents are asked to quickly provide a dichotomous response. Two personality assessments using RRM were developed and reliability and validity evidence across four independent samples were evaluated. Both RRM as

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Grenczer, Maria, Judit Zsuga, Laszlo Majoros, et al. "Effect of asymmetry of concentration–response curves on the results obtained by the receptorial responsiveness method (RRM): an in silico study." Canadian Journal of Physiology and Pharmacology 88, no. 11 (2010): 1074–83. http://dx.doi.org/10.1139/y10-089.

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The receptorial responsiveness method (RRM) was proposed to estimate changes in the concentration of an agonist in the microenvironment of its receptor. Usually, this is done by providing the equieffective concentration of another agonist for the same receptor or for a largely overlapping postreceptorial signaling (“test agonist”). The RRM is a special nonlinear regression algorithm to analyze a concentration–response (E/c) curve that represents the simultaneous actions of a single agonist concentration to be estimated and of increasing concentrations of the test agonist. The aim of this study

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Szabo, Adrienn Monika, Gabor Viczjan, Tamas Erdei, et al. "Accuracy and Precision of the Receptorial Responsiveness Method (RRM) in the Quantification of A1 Adenosine Receptor Agonists." International Journal of Molecular Sciences 20, no. 24 (2019): 6264. http://dx.doi.org/10.3390/ijms20246264.

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The receptorial responsiveness method (RRM) is a procedure that is based on a simple nonlinear regression while using a model with two variables (X, Y) and (at least) one parameter to be determined (cx). The model of RRM describes the co-action of two agonists that consume the same response capacity (due to the use of the same postreceptorial signaling in a biological system). While using RRM, uniquely, an acute increase in the concentration of an agonist (near the receptors) can be quantified (as cx), via evaluating E/c curves that were constructed with the same or another agonist in the same

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Narjis, Ghulam, Javid Shabbir, and Ronald Onyango. "Partial Randomized Response Model for Simultaneous Estimation of Means of Two Sensitive Variables." Mathematical Problems in Engineering 2022 (August 23, 2022): 1–13. http://dx.doi.org/10.1155/2022/6083646.

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In this study, a new partial randomized response model (RRM) has been proposed for estimating the population mean of two quantitative sensitive variables simultaneously. The utility of proposed model under stratification is also explored. The efficiency comparisons of the proposed model under simple and stratified random sampling are carried out numerically. A real data set was collected through direct questioning, proposed partial RRM and competitor randomized device from the students of statistics and animal sciences departments of Quaid-I-Azam University Islamabad, Pakistan. The performance

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Li, Xiao Wen, Guo Zhong Wang, and Gang Zhou. "RRM Conformance Testing Validation of Cell Handover in TD-LTE System." Advanced Materials Research 926-930 (May 2014): 2088–91. http://dx.doi.org/10.4028/www.scientific.net/amr.926-930.2088.

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In order to verify the protocol conformance of RRM (radio resource management) handover procedure in TD-LTE system, We proposed an implementation program of terminal RRM conformance test system with TTCN-3 (Testing and Test Control Notation version 3), designed the testing process of handover in cells, developed the corresponding test cases, and completed the protocol conformance test of Terminal RRM Handover procedure.

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Kim, Y. J., and B. S. Baker. "Isolation of RRM-type RNA-binding protein genes and the analysis of their relatedness by using a numerical approach." Molecular and Cellular Biology 13, no. 1 (1993): 174–83. http://dx.doi.org/10.1128/mcb.13.1.174-183.1993.

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Proteins with RNA recognition motifs (RRMs) have important roles in a great many aspects of RNA metabolism. However, this family has yet to be systematically studied in any single organism. In order to investigate the size of the RRM gene family in Drosophila melanogaster and to clone members of this family, we used a polymerase chain reaction (PCR) with highly degenerate oligonucleotides to amplify DNA fragments between the RNP-1 and RNP-2 consensus sequences of the RRM proteins. Cloning and sequencing of 124 PCR products revealed 12 different RRM sequences (RRM1 to RRM12). When PCR products

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Kim, Y. J., and B. S. Baker. "Isolation of RRM-type RNA-binding protein genes and the analysis of their relatedness by using a numerical approach." Molecular and Cellular Biology 13, no. 1 (1993): 174–83. http://dx.doi.org/10.1128/mcb.13.1.174.

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Proteins with RNA recognition motifs (RRMs) have important roles in a great many aspects of RNA metabolism. However, this family has yet to be systematically studied in any single organism. In order to investigate the size of the RRM gene family in Drosophila melanogaster and to clone members of this family, we used a polymerase chain reaction (PCR) with highly degenerate oligonucleotides to amplify DNA fragments between the RNP-1 and RNP-2 consensus sequences of the RRM proteins. Cloning and sequencing of 124 PCR products revealed 12 different RRM sequences (RRM1 to RRM12). When PCR products

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Zhou, Qiu Gen, Xiao Jing Fu, Guo Yu Xu, et al. "Vascular insulin resistance related to endoplasmic reticulum stress in aortas from a rat model of chronic kidney disease." American Journal of Physiology-Heart and Circulatory Physiology 303, no. 9 (2012): H1154—H1165. http://dx.doi.org/10.1152/ajpheart.00407.2012.

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Metabolic insulin resistance has been demonstrated in patients with nondiabetic chronic kidney disease (CKD), yet their vascular insulin signaling remains poorly understood. Here we tested the hypothesis that vascular insulin signaling was impaired and related with endoplasmic reticulum (ER) stress in aortas from the reduced renal mass (RRM) model of CKD. The activity of insulin signaling and markers of ER were determined in aortas from rats with RRM and cultured human umbilical vein endothelial cells. Tyrosine phosphorylation of insulin receptor-β and insulin receptor substrate (IRS)-1 and ph

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Wong, Stephanie M., Carla Apostolova, Elisheva Eisenberg, and William D. Foulkes. "Counselling Framework for Germline BRCA1/2 and PALB2 Carriers Considering Risk-Reducing Mastectomy." Current Oncology 31, no. 1 (2024): 350–65. http://dx.doi.org/10.3390/curroncol31010023.

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Female BRCA1/2 and PALB2 germline pathogenic variant carriers have an increased lifetime risk of breast cancer and may wish to consider risk-reducing mastectomy (RRM) for surgical prevention. Quantifying the residual lifetime risk and absolute benefit from RRM requires careful consideration of a patient’s age, pathogenic variant, and their personal history of breast or ovarian cancer. Historically, patients have been counselled that RRM does not necessarily prolong survival relative to high-risk surveillance, although recent studies suggest a possible survival benefit of RRM in BRCA1 carriers.

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Tang, Qi, Stephen A. Klein, Shaocheng Xie, et al. "Regionally refined test bed in E3SM atmosphere model version 1 (EAMv1) and applications for high-resolution modeling." Geoscientific Model Development 12, no. 7 (2019): 2679–706. http://dx.doi.org/10.5194/gmd-12-2679-2019.

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Abstract. Climate simulations with more accurate process-level representation at finer resolutions (<100 km) are a pressing need in order to provide more detailed actionable information to policy makers regarding extreme events in a changing climate. Computational limitation is a major obstacle for building and running high-resolution (HR, here 0.25∘ average grid spacing at the Equator) models (HRMs). A more affordable path to HRMs is to use a global regionally refined model (RRM), which only simulates a portion of the globe at HR while the remaining is at low resolution (LR, 1∘). In this s

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Wahl, Carly A., Rudi A. Marciniak, Barbara B. Meyer, and Kyle T. Ebersole. "Association Between Call Volume and Perceptions of Stress and Recovery in Active-Duty Firefighters." Fire 8, no. 7 (2025): 268. https://doi.org/10.3390/fire8070268.

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Firefighting is a physically, mentally, and emotionally demanding occupation. These demands are exacerbated by an increase in workload, resulting in an increase in stress and a decrease in recovery. While researchers have examined the influence of workload on stress perceptions, little is known about firefighter perceptions of recovery generally, and no research investigating perceptions of holistic recovery (i.e., physical, mental, and emotional) exists. The purpose of this study was to determine the association between acute workload (i.e., call volume) and firefighter perceptions of stress

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Kang, Eunhye, Hyerim Kang, Changhoon Lee, et al. "Abstract P1-05-11: The timing of BRCA1/2 germline testing and patient’s decision toward the risk-reducing mastectomy in breast cancer." Clinical Cancer Research 31, no. 12_Supplement (2025): P1–05–11—P1–05–11. https://doi.org/10.1158/1557-3265.sabcs24-p1-05-11.

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Abstract Background: BRCA1 and BRCA2 pathogenic variants significantly increase the risk of breast cancer. Risk-reducing mastectomy (RRM) is an option for these patients, offering substantial risk reduction. However, the decision to undergo RRM is complex and influenced by various factors. This study aims to analyze factors influencing RRM decisions in BRCA mutation carriers, with a particular focus on how the timing of BRCA testing affects the choice to undergo RRM. Methods: We conducted a retrospective analysis of 499 breast cancer patients diagnosed with germline BRCA1/2 pathogenic variants

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Lai, En Yin, Zaiming Luo, Maristela L. Onozato, et al. "Effects of the antioxidant drug tempol on renal oxygenation in mice with reduced renal mass." American Journal of Physiology-Renal Physiology 303, no. 1 (2012): F64—F74. http://dx.doi.org/10.1152/ajprenal.00005.2012.

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We tested the hypothesis that reactive oxygen species (ROS) contributed to renal hypoxia in C57BL/6 mice with ⅚ surgical reduction of renal mass (RRM). ROS can activate the mitochondrial uncoupling protein 2 (UCP-2) and increase O2 usage. However, UCP-2 can be inactivated by glutathionylation. Mice were fed normal (NS)- or high-salt (HS) diets, and HS mice received the antioxidant drug tempol or vehicle for 3 mo. Since salt intake did not affect the tubular Na+ transport per O2 consumed (TNa/QO2), further studies were confined to HS mice. RRM mice had increased excretion of 8-isoprostane F2α a

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Herold, Natalie, Martin Hellmich, Frank Lichtenheldt, et al. "Satisfaction and Quality of Life of Healthy and Unilateral Diseased BRCA1/2 Pathogenic Variant Carriers after Risk-Reducing Mastectomy and Reconstruction Using the BREAST-Q Questionnaire." Genes 13, no. 8 (2022): 1357. http://dx.doi.org/10.3390/genes13081357.

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Risk-reducing mastectomy (RRM) is the most efficient form of breast cancer (BC) risk reduction in BRCA1/2 pathogenic variant (pV) carriers. However, this intervention in physical integrity is associated with significant morbidity. We assessed long-term perception of satisfaction and health-related quality of life (QoL) after bilateral RRM and reconstruction using the validated BREAST-Q. We searched the prospective database of the Center for Hereditary Breast and Ovarian Cancer Cologne for previvors and survivors who underwent bilateral RRM from 1994 to 2015 and evaluated the results of their B

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Rodríguez-Lozano, Francisco Javier, Sergio López-García, David García-Bernal, et al. "In Vitro Effect of Putty Calcium Silicate Materials on Human Periodontal Ligament Stem Cells." Applied Sciences 10, no. 1 (2020): 325. http://dx.doi.org/10.3390/app10010325.

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New bioactive materials have been developed for retrograde root filling. These materials come into contact with vital tissues and facilitate biomineralization and apical repair. The objective of this study was to evaluate the cytocompatibility and bioactivity of two bioactive cements, Bio-C Repair (Angelus, Londrina, Pr, Brazil) and TotalFill BC RRM putty (FGK, Dentaire SA, La-Chaux-de-fonds, Switzerland). The biological properties in human periodontal ligament stem cells (hPDLSCs) that were exposed to Bio-C Repair and TotalFill BC RRM putty were studied. Cell viability, migration, and cell ad

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Negussie, E., K. Vuori, I. Strandén, and E. A. Mäntysaari. "New Test Day Model for the Genetic Evaluation of mastitis in dairy cattle." Suomen Maataloustieteellisen Seuran Tiedote, no. 23 (January 31, 2008): 1–6. http://dx.doi.org/10.33354/smst.77002.

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In this study, genetic parameters of test-day (TD) somatic cell score (SCS) and lactation average (LA)clinical mastitis (CM) were estimated using a random regression model (RRM) that combine two differentdata models. A multitrait RRM (mt-RRM) was then developed for the genetic evaluation of mastitis.Estimates of breeding values (EBVs) from the mt-RRM were compared to corresponding multitrait LAmodel (biv-LAM) and univariate LA models (univ-LAM). A total of 147500 and about 5.6 million recordsfrom 27500 and 1.4 million Finnish Ayrshire cows were used for estimation of genetic parameters andpred

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Sauren, M., E. Pirogova, and I. Cosic. "RRM analysis of protoporphyrinogen oxidase." Australasian Physics & Engineering Sciences in Medicine 27, no. 4 (2004): 174–79. http://dx.doi.org/10.1007/bf03178646.

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Beckman, M. "VRrm Rrm: Rrm protein jump-starts idle DNA-copying equipment (Genome instability; DNA replication)." Science of Aging Knowledge Environment 2002, no. 22 (2002): 75nw—75. http://dx.doi.org/10.1126/sageke.2002.22.nw75.

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Bhura, Roohi, Emily Selig, Carmel Tovar, et al. "Abstract 2325: RNA Binding Characterization of the RRM and RRM-RGG2 Domains of EWSR1." Journal of Biological Chemistry 299, no. 3 (2023): S676. http://dx.doi.org/10.1016/j.jbc.2023.104245.

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Prasad, Mr T. Ganga, and Mrs Dr MSS Rukmini. "QoS Aware Optimal Confederation based Radio Resource Management Scheme for LTE Networks." International Journal of Engineering and Advanced Technology 9, no. 1s5 (2019): 50–54. http://dx.doi.org/10.35940/ijeat.a1014.1291s519.

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In this paper proposed for future generation Long Term Evolution (LTE) networks a radio resource management using QoS with aware QOC-RRM method. In QOC-RRM scheme we present the hybrid Recurrent Deep Neural Network (RDNN) technique to differentiate the operators by priority wise based on multiple constraints and it control the allocated resource bybase stations. For routing share queuing criterion data with other schaotic weed optimization (CWO) algorithm are proposed. Once information received each BS schedules the resources for priority user first. The proposed QOC-RRM scheme is implemented

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Nagao, T., and R. Tsutaba. "Evaluation Methods of Vertical Subgrade Reaction Modulus and Rotational Resistance Moment for Seismic Design of Embedded Foundations." Engineering, Technology & Applied Science Research 11, no. 4 (2021): 7386–92. http://dx.doi.org/10.48084/etasr.4269.

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In a seismic design of embedded foundations, the vertical Subgrade Reaction (SR) acting on a foundation bottom surface and the Rotational Resistance Moment (RRM) generated by the SR are calculated using an SR Modulus (SRM). The SRM and RRM depend on both ground rigidity and Foundation Width (FW). However, the SRM and RRM calculation methods adopted in design codes might not properly consider their FW dependency. In this study, SRM and RRM evaluation methods for embedded foundations subjected to a seismic load were examined by conducting a two-dimensional finite element analysis under the condi

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Bown, Chad P., and Kathleen Claussen. "The Rapid Response Labor Mechanism of the US–Mexico–Canada Agreement." World Trade Review 23, no. 3 (2024): 335–62. http://dx.doi.org/10.1017/s1474745624000053.

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AbstractThe US–Mexico–Canada Agreement (USMCA) introduced a new compliance institution for labor rights in trade agreements: the facility-specific Rapid Response Labor Mechanism (RRM). The RRM was developed to tackle one particular thorn in the side of North American integration – labor rights for Mexican workers – as it had had detrimental, long-term political–economic consequences for the US–Mexico trade relationship. This article reviews the unique political–economic moment in the United States and Mexico that prompted the creation of this tool. It describes how the RRM works and the consid

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Liu, Yu, and Ning Zhang. "The Development of RRM Conformance Test in TD-LTE Idle_State." Applied Mechanics and Materials 513-517 (February 2014): 905–8. http://dx.doi.org/10.4028/www.scientific.net/amm.513-517.905.

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In order for the RRM conformance of implementation in TD-LTE system idle_state, taking inter-frequency cell reselection procedure as the point of penetration, a new testing scheme is designed by developing testing and test control notation version 3(TTCN-3) test case to verify the RRM conformance. Furthermore, the test case is operated on the TTworkbench developed by German Testing tech. It also generates test execution flow chart to check the RRM conformance of idle_state functions.

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Wang, Xingchuan, Enjian Yao, and Shasha Liu. "Travel Choice Analysis under Metro Emergency Context: Utility? Regret? Or Both?" Sustainability 10, no. 11 (2018): 3852. http://dx.doi.org/10.3390/su10113852.

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With the continuous expansion of the network scale and increasing of passengers, metro emergencies such as operational equipment failure are happening more frequently. Due to the narrow space and crowds of people, metro emergencies always have more of an impact than road traffic emergencies. In order to adopt appropriate measures to ensure passenger safety and avoid risks, we need to get a better understanding of passengers’ travel choice behaviors under emergencies. Most of the existing research studies related to travel choice behaviors took the random utility maximization (RUM) principle fo

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Ferreira Coelho, Igor, Marco Antônio Peixoto, Jeniffer Santana Pinto Coelho Evangelista, et al. "Multiple-trait, random regression, and compound symmetry models for analyzing multi-environment trials in maize breeding." PLOS ONE 15, no. 11 (2020): e0242705. http://dx.doi.org/10.1371/journal.pone.0242705.

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An efficient and informative statistical method to analyze genotype-by-environment interaction (GxE) is needed in maize breeding programs. Thus, the objective of this study was to compare the effectiveness of multiple-trait models (MTM), random regression models (RRM), and compound symmetry models (CSM) in the analysis of multi-environment trials (MET) in maize breeding. For this, a data set with 84 maize hybrids evaluated across four environments for the trait grain yield (GY) was used. Variance components were estimated by restricted maximum likelihood (REML), and genetic values were predict

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Sánchez-Castro, Miguel A., Milt Thomas, Mark Enns, and Scott Speidel. "260 Genetic prediction for first-service conception rate in Angus heifers using a random regression model." Journal of Animal Science 98, Supplement_4 (2020): 197–98. http://dx.doi.org/10.1093/jas/skaa278.364.

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Abstract First-service conception rate (FSCR) can be defined as the probability of a heifer conceiving in response to her first artificial insemination (AI). Given the binary nature of its phenotypes, FSCR has been typically evaluated using animal threshold models (ATM). However, susceptibility of these models to the extreme-category problem (ECP) limits their ability to use all available information to calculate Expected Progeny Differences (EPD). Random regression models (RRM) represent an alternative method to evaluate binary traits, and they are not affected by ECP. Nevertheless, RRM were

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Gupta, Alok, Pritpal Singh, Gurdeep Singh, Bhallan Singh Sekhon, and Gurjinder Pal Singh Sodhi. "On Farm Testing of Rice Residue Management Techniques for Wheat (Triticum aestivum L.) Establishment in Punjab." Indian Journal of Extension Education 57, no. 4 (2021): 85–88. http://dx.doi.org/10.48165/ijee.2021.57419.

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Rice residue management (RRM) has been the key component of systems’ sustainability. The paper reports the effect of different RRM and wheat (Triticum aestivum L.) establishment methods on productivity and yield contributing attributes through farmer participatory mode in south-western Punjab. Different RRM technologies including rice residue removal, residue incorporation and residue retention on soil as surface mulch were evaluated. Wheat grain yield was significantly (p<0.05) higher with happy seeder method of wheat establishment following chopping of loose rice stubble, which acts as su

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Zimovjanova, Martina, Zuzana Bielcikova, Michaela Miskovicova, et al. "Uptake and Effectiveness of Risk-Reducing Surgeries in Unaffected Female BRCA1 and BRCA2 Carriers: A Single Institution Experience in the Czech Republic." Cancers 15, no. 4 (2023): 1072. http://dx.doi.org/10.3390/cancers15041072.

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Unnafected female carriers of BRCA1 and BRCA2 pathogenic/likely pathogenic variants (P/LPVs) are at higher risk of breast cancer (BC) and ovarian cancer (OC). In the retrospective single-institution study in the Czech Republic, we analyzed the rate, longitudinal trends, and effectiveness of prophylactic risk-reducing mastectomy (RRM) and risk-reducing salpingo-oophorectomy (RRSO) on the incidence of BC and OC in BRCA1/2 carriers diagnosed between years (y) 2000 to 2020. The study included 496 healthy female BRCA1/2 carriers. The median follow-up was 6.0 years. RRM was performed in 156 (31.5%,

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Wang, Yanhao, Jiping Zheng, and Fanxu Meng. "Improved Algorithm for Regret Ratio Minimization in Multi-Objective Submodular Maximization." Proceedings of the AAAI Conference on Artificial Intelligence 37, no. 10 (2023): 12500–12508. http://dx.doi.org/10.1609/aaai.v37i10.26472.

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Submodular maximization has attracted extensive attention due to its numerous applications in machine learning and artificial intelligence. Many real-world problems require maximizing multiple submodular objective functions at the same time. In such cases, a common approach is to select a representative subset of Pareto optimal solutions with different trade-offs among multiple objectives. To this end, in this paper, we investigate the regret ratio minimization (RRM) problem in multi-objective submodular maximization, which aims to find at most k solutions to best approximate all Pareto optima

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Namazova-Baranova, Leyla S., Viktor A. Gankovskiy, Irina V. Zelenkova, Svetlana G. Gubanova, Alexander V. Pashkov, and George A. Karkashadze. "Complex Approach to Diagnosis of Nasal Cavity and Nasopharyngeal Pathologies in Children. Initial Results." Pediatric pharmacology 19, no. 1 (2022): 20–26. http://dx.doi.org/10.15690/pf.v19i1.2345.

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Background. Nasal cavity and nasopharyngeal pathology are crucial and common issue in pediatric otorhinolaryngology. One of the major reasons for the nasal breathing difficulties are adenoids, allergic rhinitis, acute rhinitis, rhinosinusitis, nasal septum deviation. All these diseases can occur individually and in combination with each other, while clinical signs can be similar.Objective. The aim of the study is study and estimate the condition of nasal breathing and sense of smell in children with different nasal and nasopharyngeal pathology.Methods. The study included 128 children, all chil

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