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Journal articles on the topic 'Rs4680'

Author: Grafiati

Published: 4 June 2021

Last updated: 16 February 2022

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1

Khalil, Heba, Susan M. Sereika, Feng Dai, et al. "OPRM1 and COMT Gene–Gene Interaction Is Associated With Postoperative Pain and Opioid Consumption After Orthopedic Trauma." Biological Research For Nursing 19, no. 2 (2016): 170–79. http://dx.doi.org/10.1177/1099800416680474.

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Background: mu-opioid receptor ( OPRM1) and catechol-O-methyltransferase ( COMT) contribute to the neurotransmission pathway of pain. COMT affects mu receptor expression and density in the brain. The aim of this study was to explore the OPRM1 and COMT interaction effects on postoperative pain and opioid consumption. Methods: This cross-sectional exploratory study used genotype and clinical data from 153 postoperative patients. Using multiple regression analyses, four single-nucleotide polymorphisms of COMT (rs6269, rs4633, rs4818, and rs4680), their haplotypes, and diplotypes were considered f

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Vermeulen, Sita, Ad Hermus, Henk Blom, Henkjan Gellekink, Jan-Willem Muntjewerff, and Martin den Heijer. "Catechol-O-methyltransferase genotype is associated with plasma total homocysteine levels and may increase venous thrombosis risk." Thrombosis and Haemostasis 98, no. 12 (2007): 1226–31. http://dx.doi.org/10.1160/th07-05-0381.

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SummaryA disturbed methylation has been proposed as a mechanism via which homocysteine is associated with diseases like vascular disease, neural tube defects and mental disorders. Catechol- O-methyltransferase (COMT) is involved in the S-adenosylmethionine- dependent methylation of catecholamines and catecholestrogens and in this way contributes to homocysteine synthesis. COMT dysfunction has been related to schizophrenia and breast cancer. We hypothesized that COMT dysfunction by virtue of functional genetic polymorphisms may affect plasma total homocysteine (tHcy). Our primary objective was

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Ivanova, Svetlana A., Valentina M. Alifirova, Ivan V. Pozhidaev, et al. "Polymorphisms of Catechol-O-Methyl Transferase (COMT) Gene in Vulnerability to Levodopa-Induced Dyskinesia." Journal of Pharmacy & Pharmaceutical Sciences 21 (August 3, 2018): 340–46. http://dx.doi.org/10.18433/jpps29903.

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Purpose. Parkinson's disease (PD), a common neurodegenerative disorder, is usually treated with Levodopa (L-DOPA). The use of this drug, however, is severely limited by the development of side effects of the motor system: Levodopa-induced dyskinesia (LID). The aim of this study is to investigate the association between seven COMT gene single-nucleotide polymorphisms (SNPs) and the development of LID in patients with PD. Methods. 232 Caucasian patients with PD were investigated. 212 patients with PD received Levodopa therapy. Dyskinesia was assessed with the use of the Abnormal Involuntary Move

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Voisey, J., C. D. Swagell, I. P. Hughes, B. R. Lawford, R. M. Young, and C. P. Morris. "HapMap tag-SNP analysis confirms a role for COMT in schizophrenia risk and reveals a novel association." European Psychiatry 27, no. 5 (2012): 372–76. http://dx.doi.org/10.1016/j.eurpsy.2010.08.004.

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AbstractCatechol-O-methyl transferase (COMT) encodes an enzyme involved in the metabolism of dopamine and maps to a commonly deleted region that increases schizophrenia risk. A non-synonymous polymorphism (rs4680) in COMT has been previously found to be associated with schizophrenia and results in altered activity levels of COMT. Using a haplotype block-based gene-tagging approach we conducted an association study of seven COMT single nucleotide polymorphisms (SNPs) in 160 patients with a DSM-IV diagnosis of schizophrenia and 250 controls in an Australian population. Two polymorphisms includin

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Benedetti, F., S. Dallaspezia, C. Colombo, C. Lorenzi, A. Pirovano, and E. Smeraldi. "Effect of catechol-O-methyltransferase Val(108/158)Met polymorphism on antidepressant efficacy of fluvoxamine." European Psychiatry 25, no. 8 (2010): 476–78. http://dx.doi.org/10.1016/j.eurpsy.2009.12.007.

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AbstractRationaleThe catechol-O-methyltransferase (COMT) enzyme inactivates catecholamines, and the COMT Val(108/158)Met polymorphism (rs4680) influences the enzyme activity. Recent clinical studies found a significant effect of rs4680 on antidepressant response to fluoxetine and paroxetine, but several other studies were negative. No study considered drug plasma levels as possible nuisance covariate.ObjectivesWe studied the effect of rs4680 on response to fluvoxamine antidepressant monotherapy.Patients and methodsForty-one consecutively admitted inpatients affected by a major depressive episo

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Yu, Rwei-Ling, Shao-Ching Tu, Ruey-Meei Wu, Pei-An Lu, and Chun-Hsiang Tan. "Interactions of COMT and ALDH2 Genetic Polymorphisms on Symptoms of Parkinson’s Disease." Brain Sciences 11, no. 3 (2021): 361. http://dx.doi.org/10.3390/brainsci11030361.

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(1) Background: Monoamine neurotransmitters play essential roles in the normal functioning of our nervous system. However, the metabolism of monoamine neurotransmitters is accompanied by the production of neurotoxic metabolites, and inefficient removal of the metabolites has been suggested to cause neurodegeneration. (2) Methods: To examine the effect of reduced activity of catechol-O-methyltransferase (COMT) and aldehyde dehydrogenase 2 (ALDH2) conferred by single nucleotide polymorphisms COMT rs4680(A) and ALDH2 rs671(A) on the symptoms of patients with Parkinson’s disease (PD), a total of 1

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Суханов, А. В., С. Е. Семаев, and В. Н. Максимов. "Associations of separate working memory parameters with comt genotypes in Western Siberia." Nauchno-prakticheskii zhurnal «Medicinskaia genetika», no. 6() (June 28, 2019): 43–49. http://dx.doi.org/10.25557/2073-7998.2019.06.43-49.

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Цель. Изучить ассоциации отдельных параметров оперативной памяти с полиморфным локусом Val158Met (rs4680) гена COMT у лиц молодого возраста. Материалы и методы. 371 участник 25-44 лет отобран из популяционной выборки г. Новосибирска. Исследование включало 199 (53,6%) мужчин (36,54 ± 5,67 года) и 172 (46,4%) женщины (36,84 ± 5,75 года). Когнитивные функции оценивались стандартизованными для целей скрининга методами: запоминание 10-ти слов по методике А.Р. Лурия, корректурная проба Бурдона, методика исключения понятий (словесный вариант теста) с фиксацией времени её выполнения, а также тест на р

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8

Jin, Xin-Rong, and Zhi-Qiang Zhao. "Lack of Association between rs4680 Polymorphism in Catechol-O-Methyltransferase Gene and Alcohol Use Disorder: A Meta-Analysis." Disease Markers 2020 (November 17, 2020): 1–9. http://dx.doi.org/10.1155/2020/8850859.

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Background. The underlying mechanisms of alcohol use disorder (AUD) are regarded to be strongly associated with genetic factors. Although great efforts have been made to identify the association of rs4680 polymorphism in the catechol-o-methyltransferase gene and risk to AUD, the outcomes were still inconsistent. This study is aimed at exploring the association of rs4680 polymorphism and AUD by using a meta-analysis approach. Methods. Literature searching was undertaken across PubMed, Embase, Web of Science, Chinese National Knowledge Infrastructure (CNKI), and Wanfang databases. We set the sea

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Kandratsenka, H. S., N. G. Danilenko, I. M. Haylaenka та ін. "Association of СОМТ, DRD2/ANKK1, MTHFR, MIR 137, DNMT3B polymorphisms with the clinical features of schizophrenia patients in acute stage and remission". Doklady of the National Academy of Sciences of Belarus 65, № 1 (2021): 76–86. http://dx.doi.org/10.29235/1561-8323-2021-65-1-76-86.

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Updated view of genetic features of schizophrenia based on rare SNPs/CNVs with a huge influence on a disease and common SNPs with a small effect of each allele is presented. Altogether these genetic factors are acting to create neuropathophysiological disturbances observed in schizophrenia. Association of five polymorphisms MIR137 rs1625579, DRD2/ANKK1 rs1800497, MTHFR rs1801133, DNMT3B rs2424913, СОМТ rs4680 with the risk of schizophrenia in the Belarusian population, the level of symptoms of schizophrenia patients assessed by PANSS in the acute stage and remission, cognitive impairments, and

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Spasova, Arina P., I. V. Kurbatova, O. Y. Barysheva, and G. P. Tikhova. "Relationship between catechol-o-methyltransferase gene polymorphism and pain syndrome in breast cancer patients." Regional Anesthesia and Acute Pain Management 14, no. 2 (2020): 72–85. http://dx.doi.org/10.17816/1993-6508-2020-14-2-72-85.

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The goal of the study was to explore the influence of single-nucleotide polymorphisms of the COMT gene on the formation and features of pain syndrome, the level of anxiety, and the need for narcotic analgesics in patients with breast cancer. Materials and methods. The intensity of pain and opioid consumption in the postoperative period were evaluated in 58 patients who met the inclusion criteria of the study and were operated for breast cancer. The frequency of chronic pain syndrome after mastectomy was studied in the same group of patients after a year by using short pain questionnaires

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11

Vai, B., M. Riberto, S. Poletti, et al. "Catechol-O-methyltransferase Val(108/158)Met polymorphism affects fronto-limbic connectivity during emotional processing in bipolar disorder." European Psychiatry 41, no. 1 (2017): 53–59. http://dx.doi.org/10.1016/j.eurpsy.2016.10.002.

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AbstractCatechol-O-methyltransferase (COMT) inactivates catecholamines, Val/Val genotype was associated to an increased amygdala (Amy) response to negative stimuli and can influence the symptoms severity and the outcome of bipolar disorder, probably mediated by the COMT polymorphism (rs4680) interaction between cortical and subcortical dopaminergic neurotransmission. The aim of this study is to explore how rs4680 and implicit emotional processing of negative emotional stimuli could interact in affecting the Amy connectivity in bipolar depression. Forty-five BD patients (34 Met carriers vs. 11

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Madzarac, Zoran, Lucija Tudor, Marina Sagud, Gordana Nedic Erjavec, Alma Mihaljevic Peles, and Nela Pivac. "The Associations between COMT and MAO-B Genetic Variants with Negative Symptoms in Patients with Schizophrenia." Current Issues in Molecular Biology 43, no. 2 (2021): 618–36. http://dx.doi.org/10.3390/cimb43020045.

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Negative symptoms of schizophrenia, including anhedonia, represent a heavy burden on patients and their relatives. These symptoms are associated with cortical hypodopamynergia and impaired striatal dopamine release in response to reward stimuli. Catechol-O-methyltransferase (COMT) and monoamine oxidase type B (MAO-B) degrade dopamine and affect its neurotransmission. The study determined the association between COMT rs4680 and rs4818, MAO-B rs1799836 and rs6651806 polymorphisms, the severity of negative symptoms, and physical and social anhedonia in schizophrenia. Sex-dependent associations we

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Spasova, Arina P., I. V. Kurbatova, O. Yu Barysheva, and G. P. Tikhova. "THE INFLUENCE OF SINGLE-NUCLEOTIDE POLYMORPHISMS OF CATECHOL-O-METHYLTRANSFERASE GENE ON THE FORMATION OF PAIN SYNDROME AND EFFECTIVENESS OF ANALGESIA IN ONCOLOGICAL PATIENTS." Regional Anesthesia and Acute Pain Management 11, no. 2 (2017): 112–27. http://dx.doi.org/10.18821/1993-6508-2017-11-2-112-127.

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The objective is to study the effect of single-nucleotide polymorphisms (SNPs) of COMT gene on the formation and characteristics of chronic pain, level of anxiety and depression, effectiveness of analgesia in oncological patients. Material and Methods. The study includes 196 patients with oncological pathology. The formation of chronic pain syndrome was estimated in all patients one year after surgery using the assessment of pain intensity by numeric rating scale, pain questionnaire of McGill, PainDetect. Basing on the patients genotyping data the genotypes and haplotypes frequency distributio

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TUNALI, Seçil, Selin YİĞİT, Canan SERCAN, Tolga POLAT, and Rıdvan EKMEKÇİ. "Profesyonel Voleybolcularda Katekol-O-Metiltransferaz (COMT) rs4680 Polimorfizminin Belirlenmesi." Eurasian Research in Sport Science 4, no. 1 (2019): 1–6. http://dx.doi.org/10.22396/eriss.2019153188.

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Gámez Saiz, Ilse, Beatriz Elena Camarena Medellin, María Alejandra Andrade Salcedo, Claudia Becerra Palars, Sandra Hernández Muñoz, and Hiram Ortega Ortiz. "ASOCIACION DEL POLIMORFISMO VAL108/158 MET Y RESPUESTA AL TRATAMIENTO CON LITIO." EPISTEMUS 12, no. 24 (2018): 7–12. http://dx.doi.org/10.36790/epistemus.v12i24.56.

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Se realizó un estudio prospectivo, descriptivo y de asociación de casos y controles con respuesta y no respuesta al tratamiento con litio. Se realizó posteriormente extracción de DNA por medio de buffy coat y, genotipificación del rs4680 mediante el método fluorogénico 5´-exonucleasa y discriminación alélica por el software applyed biosystem 1.3 V. Se utilizó la escala de Alda para valorar la respuesta a litio. El análisis estadístico se realizó por el programa SPSS. El análisis entre los pacientes respondedores y no respondedores a litio no mostró diferencias estadísticamente significativas t

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Fernández-de-las-Peñas, César, Silvia Ambite-Quesada, Lidiane L. Florencio, María Palacios-Ceña, Carlos Ordás-Bandera, and Lars Arendt-Nielsen. "Catechol-O-Methyltransferase Val158Met Polymorphism Is Associated with Anxiety, Depression, and Widespread Pressure Pain Sensitivity in Women with Chronic, but Not Episodic, Migraine." Pain Medicine 20, no. 7 (2018): 1409–17. http://dx.doi.org/10.1093/pm/pny237.

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Abstract Objectives To analyze the association between the rs4680 catechol-O-methyltransferase Val158Met polymorphism and to determine the association of this polymorphism with clinical, psychological, and pain sensitivity variables in women with episodic or chronic migraine. Methods Fifty women with episodic migraine, 50 with chronic migraine, and 50 matched healthy women participated. After amplifying the Val158Met polymorphism by polymerase chain reaction, we assessed genotype frequencies and allele distributions. Participants were classified according to the Val158Met polymorphism genotype

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Moreno-Galván, Mónica, Norma Estela Herrera-González, Vera Robles-Pérez, Julio C. Velasco-Rodríguez, Roberto Tapia-Conyer, and Elsa Sarti. "Impact of Cyp1A1 and Comt Genotypes on Breast Cancer Risk in Mexican Women: A Pilot Study." International Journal of Biological Markers 25, no. 3 (2010): 157–63. http://dx.doi.org/10.1177/172460081002500306.

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Background Data suggest that estrogen-metabolizing genes may be involved in breast cancer carcinogenesis. Objective The aim of this study was to determine the association of CYP1A1 and COMT polymorphisms with this disease. Material and methods: A pilot case-control study was conducted with Mexican women. Ninety-one breast cancer patients and 94 healthy controls were selected. Epidemiological and clinical questionnaires were answered by all participants, and genotyping data were obtained. CYP1A1 3801 T>C (rs4646903), CYP1A1 4889 A>G (rs1048943) and COMT 1947 G>A (rs4680) polymorphisms

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Morris, Kim, Brian Dean, Will Woods, et al. "S176. A PRELIMINARY INVESTIGATION OF COMT GENE INVOLVEMENT IN COGNITIVE FLEXIBILITY AND ATTENTION IN SCHIZOPHRENIA SPECTRUM DISORDERS." Schizophrenia Bulletin 46, Supplement_1 (2020): S104—S105. http://dx.doi.org/10.1093/schbul/sbaa031.242.

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Abstract Background Schizophrenia spectrum disorders (SSD) are often characterised by a plateau or decline in cognitive abilities early in the prodrome. The cause of developmental alteration remains unknown, and investigation of genetic involvement in cognitive function in these disorders may assist the understanding of the underlying neurobiological mechanisms involved. Variation at two single nucleotide polymorphisms (SNPs) of the catechol-O-methyltransferase (COMT) gene have previously shown an influence on COMT protein levels and cognition; rs4680 and rs4818. Here we investigate the influe

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Sun, Shi-Hua, Xia Hu, Ji-Yu Zhang, Hui-Min Qiu, Xianchen Liu, and Cun-Xian Jia. "The COMT rs4680 polymorphism and suicide attempt in rural Shandong, China." Psychiatric Genetics 26, no. 4 (2016): 166–71. http://dx.doi.org/10.1097/ypg.0000000000000133.

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Hall, Kathryn T., Julie E. Buring, Kenneth J. Mukamal, et al. "COMT and Alpha-Tocopherol Effects in Cancer Prevention: Gene-Supplement Interactions in Two Randomized Clinical Trials." JNCI: Journal of the National Cancer Institute 111, no. 7 (2019): 684–94. http://dx.doi.org/10.1093/jnci/djy204.

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AbstractBackgroundVitamins are among the most frequently used supplements (48% of US adults). However, little is known about contributions of genetic variation to their efficacy and safety. Multiple pathways link catechol-O-methyltransferase (COMT) to the vitamin E supplement, alpha-tocopherol, and cancer.MethodsHere we determined if COMT exerted pharmacogenetic effects on cancer prevention in two randomized trials of alpha-tocopherol supplementation. Pharmacogenetic effects of common COMT rs4680 (val158met), which encodes a nonsynonymous valine-to-methionine substitution, were examined in the

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Chhabra, Harleen, Venkataram Shivakumar, Manjula Subbanna, et al. "Gene polymorphisms and response to transcranial direct current stimulation for auditory verbal hallucinations in schizophrenia." Acta Neuropsychiatrica 30, no. 4 (2018): 218–25. http://dx.doi.org/10.1017/neu.2018.4.

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AbstractObjectiveRecent observations demonstrate a significant ameliorative effect of add-on transcranial direct current stimulation (tDCS) on auditory verbal hallucinations (AVHs) in schizophrenia. Of the many SNPs, NRG1 rs35753505 and catechol-o-methyl transferase (COMT) rs4680 polymorphisms have shown to have a strong association with neuroplasticity effect in schizophrenia.MethodsSchizophrenia patients (n=32) with treatment resistant auditory hallucinations were administered with an add-on tDCS. The COMT (rs4680) and NRG1 (rs35753505) genotypes were determined. The COMT genotypes were cate

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Szezerbaty, Stheace Kelly Fernandes, Carlos Alexandre Martins Zicarelli, Luana Oliveira de Lima, Priscila Daniele Oliveira Perrucini, Karen Barros Parron Fernandes, and Regina Célia Poli-Frederico. "COMT rs4680 single nucleotide polymorphism, ethnicity, and age are associated with fibromyalgia in women." Research, Society and Development 10, no. 7 (2021): e15010715225. http://dx.doi.org/10.33448/rsd-v10i7.15225.

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To investigate the influence of the catechol-O-methyltransferase enzyme (COMT) single nucleotide polymorphism (SNP) rs4680 (G/A) on fibromyalgia in women. In this observational study of case-control type 29 women with a diagnosis of FM (cases) and 31 healthy non-fibromyalgia women (controls). Sociodemographic and anthropometric data were collected, as well as data relating to Symptom Severity Scale and Generalized Pain Index and peripheral blood samples for DNA extraction; genotypic analyzes were performed by PCR-SSP. We observed that rs4680 AA genotype was more frequently observed in fibromya

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Pan, W., and H. Liao. "Correlations between the COMT gene rs4680 polymorphism and susceptibility to ovarian cancer." Genetics and Molecular Research 14, no. 4 (2015): 16813–18. http://dx.doi.org/10.4238/2015.december.14.8.

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Sobolev, Vladimir, Luiza Sakaniya, Artemii Tretiakov, et al. "Association of GA genotype of SNP rs4680 in COMT gene with psoriasis." Archives of Dermatological Research 311, no. 4 (2019): 309–15. http://dx.doi.org/10.1007/s00403-019-01904-1.

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Zhang, Yingze, Qilu Zeng, Inna Belfer, et al. "Association of Genetic Variation in the Catechol-O-Methyl Transferase Gene with Pain and Six Minute Walk Distance in Sickle Cell Anemia Patients From the Walk-PHaSST Study." Blood 118, no. 21 (2011): 1075. http://dx.doi.org/10.1182/blood.v118.21.1075.1075.

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Abstract Abstract 1075 Background: Pain crisis is the hallmark of sickle cell disease (SCD) but varies in frequency and severity. Variation in pain sensitivity and perception among individuals is partially attributed to genetic factors. Catechol-O-methyltransferase (COMT) regulates neurotransmission and plays an important role in the perception of pain sensation. Three major COMT haplotypes are associated with COMT activity and correlate with high, average and low pain sensitivity (HPS, APS, and LPS) in Caucasians. However, the role of COMT genetic variants in SCD pain has not been explored. M

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Ivanov, Hristo Y., Branimir Velinov, Gergana Kyosovksa, Denitsa Grigorova, and Peter Shopov. "Exploring Pharmacogenetic Variation in a Bulgarian Psychiatric Cohort." Folia Medica 63, no. 3 (2021): 365–71. http://dx.doi.org/10.3897/folmed.63.e61484.

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Introduction: Pharmacogenetics in psychiatry is currently gaining momentum. The efficiency of antipsychotic therapy is often limited by the lack of response and the presence of side effects. Pharmacogenetic variation is probably one of the causative factors for theobserved interindividual differences in the response to and the side effects of antipsychotics, which could be addressed and whose negative effects could be avoided or mitigated.Aim: The present study aimed to conduct a comprehensive analysis of the frequency of DRD2 rs1799732, COMT rs4680, MC4R rs489693, and HTR2C rs3813929 in Bulga

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Fernández-de-las-Peñas, César, Silvia Ambite-Quesada, Rosa Ortíz-Gutiérrez, Ricardo Ortega-Santiago, Antonio Gil-Crujera, and Ana B. Caminero. "Catechol-O-Methyltransferase Val158Met Polymorphism (rs4680) Is Associated With Pain in Multiple Sclerosis." Journal of Pain 14, no. 12 (2013): 1719–23. http://dx.doi.org/10.1016/j.jpain.2013.09.007.

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Xu, Qiang, Yongqin Xiong, Congcong Yuan, et al. "ZNF804A rs1344706 interacts with COMT rs4680 to affect prefrontal volume in healthy adults." Brain Imaging and Behavior 12, no. 1 (2017): 13–19. http://dx.doi.org/10.1007/s11682-016-9671-x.

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Unal, D., M. F. Unal, M. Alikaşifoğlu, A. Cetinkaya, and S. Karahan. "Neuropsychological correlates of ADRA2A(rs1800544) and COMT(rs4680) polymorphisms in Turkish ADHD patients." European Neuropsychopharmacology 28 (March 2018): S63—S64. http://dx.doi.org/10.1016/j.euroneuro.2017.12.094.

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Kumar, Pradeep, Garima Singh, and Vandana Rai. "Evaluation of COMT Gene rs4680 Polymorphism as a Risk Factor for Endometrial Cancer." Indian Journal of Clinical Biochemistry 35, no. 1 (2018): 63–71. http://dx.doi.org/10.1007/s12291-018-0799-x.

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Fernández-de-las-Peñas, César. "Catechol-O-Methyltransferase Val158Met Polymorphism is Associated with Pain and Disability, but not Widespread Pressure Pain Sensitivity, in Women with Carpal Tunnel Syndrome." Pain Physician 5;16, no. 5;9 (2013): E591—E600. http://dx.doi.org/10.36076/ppj.2013/16/e591.

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Background: The genetic influence of Val158Met polymorphisms, one of the potential genetic determinants for nociceptive processing, has not been previously investigated in women with carpal tunnel syndrome (CTS). Objectives: To investigate the association between the Val158Met polymorphism with CTS and to assess the relationship between the Val158Met polymorphism and the clinical outcomes and widespread pressure pain hypersensitivity in women with CTS. Study Design: Case control study. Setting: Neurology department at an urban hospital. Method: One hundred nine (n = 109) women (mean age: 47 ±

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Sanjuan, J., J. Costas, and M. D. Molto. "Gene environmental interaction in psychiatry: The 5-HTTLPR and COMT story from an evolutionary point of view." European Psychiatry 26, S2 (2011): 2054. http://dx.doi.org/10.1016/s0924-9338(11)73757-9.

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The general medical model explains that there are genetic and environmental risks and protective factors in the aetiology of any complex disease. The main idea supported by this model is the existence of good and bad polymorphisms. We present a review of the literature and some examples of our own empirical studies about this issue in psychiatry; with special focus on the methodological problems of this medical model.In relation with 5-HTTLPR we present the results of a longitudinal study of 1804 women. In this study the “LL” genotype seems to be a risk factor for post-partum depression, proba

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Gafarov, V. V., E. A. Gromova, D. O. Panov, et al. "COMT Val158Met (rs4680) polymorphism and vital exhaustion in an open 45–64-year-old population (international epidemiological WHO MONICA and HAPIEE programs)." Neurology, Neuropsychiatry, Psychosomatics 11, no. 4 (2019): 57–60. http://dx.doi.org/10.14412/2074-2711-2019-4-57-60.

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Objective: to study the association of the polymorphic genotypes of rs4680 in the catechol-O-methyl transferase (COMT) gene with vital exhaustion (VE) in a 45–64-year-old population. Patients and methods. A representative sample of a 45–64-year-old population (781 men and 869 women) was surveyed within screening IV of the international Health, Alcohol and Psychological Factors in Eastern Europe (HAPIEE) program and the WHO MONICA-psychosocial program in 2003-2005. All the study participants filled out a VE scale of the WHO MONICA-psychosocial program. COMT Val158Met (rs4680) polymorphism was g

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Nicholl, Barbara I., Kate L. Holliday, Gary J. Macfarlane, et al. "No evidence for a role of the catechol-O-methyltransferase pain sensitivity haplotypes in chronic widespread pain." Annals of the Rheumatic Diseases 69, no. 11 (2010): 2009–12. http://dx.doi.org/10.1136/ard.2009.126086.

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ObjectivesThe aim of this study was to investigate the association between the catechol-O-methyltransferase (COMT) ‘pain sensitivity’ haplotypes and chronic widespread pain (CWP) in two distinct cohorts.MethodsCases of CWP and controls free of pain were selected from two population-based studies: the Epidemiology of Functional Disorders study (EPIFUND) (UK) and the European Male Ageing Study (European). The number of cases and controls were 164 and 172, and 204 and 935, respectively. Identical American College of Rheumatology criteria were used in both studies to ascertain CWP status. The EPIF

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Ioannidis, Konstantinos, Sarah A. Redden, Stephanie Valle, Samuel R. Chamberlain, and Jon E. Grant. "Problematic internet use: an exploration of associations between cognition and COMT rs4818, rs4680 haplotypes." CNS Spectrums 25, no. 3 (2019): 409–18. http://dx.doi.org/10.1017/s1092852919001019.

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ObjectiveProblematic internet users suffer from impairment in a variety of cognitive domains. Research suggests that COMT haplotypes exert differential effects on cognition. We sought to investigate differences in the genetic profiles of problematic internet users and whether those could shed light on potential cognitive differences.MethodsWe recruited 206 non-treatment seeking participants with heightened impulsive traits and obtained cross-sectional demographic, clinical, and cognitive data as well as the genetic haplotypes of COMT rs4680 and rs4818. We identified 24 participants who present

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Mir, Rashid, Musadiq Bhat, Jamsheed Javid, Chandan Jha, Alpana Saxena, and Shaheen Banu. "Potential Impact of COMT-rs4680 G > A Gene Polymorphism in Coronary Artery Disease." Journal of Cardiovascular Development and Disease 5, no. 3 (2018): 38. http://dx.doi.org/10.3390/jcdd5030038.

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Purpose: Catechol-O-methyltransferase (COMT) plays a central role in DNA repair and estrogen-induced carcinogenesis. The nonsynonymous single nucleotide polymorphism (SNP) in exon 4 G > A or Val108 > 158Met or rs4680 G > A influences COMT enzyme activity. The three phenotypes of the COMT enzyme activities include COMT A/A with low enzyme activity, COMT A/G with medium enzyme activity and COMT G/G with high enzyme activity. The Met allele is associated with low enzymatic activity resulting in higher levels of prefrontal dopamine. Conversely, the Val allele is associated with high enzym

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Morris, Kim A., Sally A. Grace, Will Woods, Brian Dean, and Susan L. Rossell. "The influence of COMT rs4680 on functional connectivity in healthy adults: A systematic review." European Journal of Neuroscience 52, no. 8 (2020): 3851–78. http://dx.doi.org/10.1111/ejn.14748.

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Hiyoshi, Mineyoshi, Hirokazu Uemura, Kokichi Arisawa, et al. "Association between the catechol-O-methyltransferase (rs4680: Val158Met) polymorphism and serum alanine aminotransferase activity." Gene 496, no. 2 (2012): 97–102. http://dx.doi.org/10.1016/j.gene.2012.01.015.

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Leźnicka, Katarzyna, Marta Niewczas, Mateusz Kurzawski, et al. "The association between COMT rs4680 and OPRM1 rs1799971 polymorphisms and temperamental traits in combat athletes." Personality and Individual Differences 124 (April 2018): 105–10. http://dx.doi.org/10.1016/j.paid.2017.12.008.

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Colloca, Luana, Yang Wang, Pedro E. Martinez, et al. "OPRM1 rs1799971, COMT rs4680, and FAAH rs324420 genes interact with placebo procedures to induce hypoalgesia." PAIN 160, no. 8 (2019): 1824–34. http://dx.doi.org/10.1097/j.pain.0000000000001578.

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Liu, Jianbo, Tingting Zhang, Yanzi Mo, and Jingbo Gong. "The COMT gene rs4680 polymorphism moderates the relationship between adult ADHD symptoms and executive dysfunction." Asian Journal of Psychiatry 56 (February 2021): 102546. http://dx.doi.org/10.1016/j.ajp.2021.102546.

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Martire, Lynn M., Stephanie J. Wilson, Brent J. Small, Yvette P. Conley, Piotr K. Janicki, and Martin J. Sliwinski. "COMT and OPRM1 genotype associations with daily knee pain variability and activity induced pain." Scandinavian Journal of Pain 10, no. 1 (2016): 6–12. http://dx.doi.org/10.1016/j.sjpain.2015.07.004.

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AbstractBackgroundOsteoarthritis (OA) of the knee is a common and increasingly prevalent condition that is one of the primary causes of chronic pain. Staying physically active protects against disability from knee OA but is also very challenging. A critical but unexamined question is whether patients at greatest risk for becoming less active are those with a genetic predisposition for greater sensitivity to daily pain.AimsWe examined day-to-day variability in knee OA pain for patients with different variants of catechol-O-methyltransferase (COMT) and mu-opioid receptor (OPRM1) single nucleotid

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Punchaichira, Toyanji Joseph, Prachi Kukshal, Triptish Bhatia, Smita Neelkanth Deshpande, and B. K. Thelma. "The effect of rs1076560 (DRD2) and rs4680 (COMT) on tardive dyskinesia and cognition in schizophrenia subjects." Psychiatric Genetics 30, no. 5 (2020): 125–35. http://dx.doi.org/10.1097/ypg.0000000000000258.

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Sengupta, Debmalya, Souradeep Banerjee, Pramiti Mukhopadhyay, et al. "A meta-analysis and in silico analysis of polymorphic variants conferring breast cancer risk in the Indian subcontinent." Future Oncology 16, no. 27 (2020): 2121–42. http://dx.doi.org/10.2217/fon-2020-0333.

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Background: Genetic association studies on breast cancer on the Indian subcontinent have yielded conflicting results, and the precise effect of these variants on breast cancer pathogenesis is not known. Methods: Genomic variants, as obtained from selected studies from the Indian subcontinent, were subjected to random-effects and fixed-effect meta-analysis. Functional annotation of the relevant variants was done through a tried and tested in silico pipeline. Results: We found rs4646903/ CYP1A1, rs1799814/ CYP1A1, rs61886492/ GCPII, del2/ GSTM1, rs4680/ COMT and rs1801394/ MTRR to be associated

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Palumbo, Sara, Veronica Mariotti, Teresa Anastasio, and Silvia Pellegrini. "G/G genotype of COMT rs4680 links altruism to traumatic life experiences in people dedicated to volunteering." International Journal of Psychophysiology 131 (October 2018): S152—S153. http://dx.doi.org/10.1016/j.ijpsycho.2018.07.406.

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Mc Fie, Sarah, Shameemah Abrahams, Jon Patricios, Jason Suter, Michael Posthumus, and Alison V. September. "The association between COMT rs4680 and 5-HTTLPR genotypes and concussion history in South African rugby union players." Journal of Sports Sciences 36, no. 8 (2017): 920–33. http://dx.doi.org/10.1080/02640414.2017.1346274.

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Hooten, W. Michael, Danqing Hu, Julie M. Cunningham, and John L. Black. "Effect of catechol-O-methyltransferase (rs4680) single-nucleotide polymorphism on opioid-induced hyperalgesia in adults with chronic pain." Molecular Pain 15 (January 2019): 174480691984892. http://dx.doi.org/10.1177/1744806919848929.

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Fie, Sarah MC, Shameemah Abrahams, Jon Patricios, Jason Suter, Michael Posthumus, and Alison V. September. "The association betweencatechol o-methyltransferase (comt) rs4680 polymorphism, harm avoidance scores, and concussion history in rugby union players." British Journal of Sports Medicine 51, no. 11 (2017): A32.2—A32. http://dx.doi.org/10.1136/bjsports-2016-097270.82.

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Usoltseva, A. A., D. V. Dmitrenko, S. N. Zobova, E. N. Bochanova, and N. A. Shnayder. "Genetic risk factors for behavioral adverse reactions in epileptic patients taking levetiracetam." Neurology, Neuropsychiatry, Psychosomatics 11, no. 4 (2019): 68–76. http://dx.doi.org/10.14412/2074-2711-2019-4-68-76.

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Levetiracetam (LEV) is an effective antiepileptic drug. Nevertheless, when the drug is used, its behavioral adverse drug reactions (ADRs), such as aggressivity, irritability, hyperexcitability, and anxiety, occur in almost 30% of cases. Recent studies show that personality traits can predispose to LEV-induced ARs.Objective: to establish genetic risk factors for behavioral ADRs in epileptic patients taking LEV. Patients and methods. Single nucleotide variants (SNVs) were chosen according to their importance for the development of impulsivity and aggressivity. At Stage 1, the dose-dependent effe

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Maria, Kotrotsou, Touloumis Charalampos, Dido Vassilakopoulou, Syriou Stavroula, Kalampoki Vasiliki, and Drakoulis Nikolaos. "Frequency Distribution of COMT Polymorphisms in Greek Patients with Schizophrenia and Controls: A Study of SNPs rs737865, rs4680, and rs165599." ISRN Psychiatry 2012 (November 1, 2012): 1–6. http://dx.doi.org/10.5402/2012/651613.

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Schizophrenia, a severe psychiatric condition, is characterized by disturbances of cognition, emotion, and social functioning. The disease affects almost 1% of world population. Recent studies evaluating the role of catechol-O-methyltransferase enzyme (COMT) polymorphisms in the pathogenesis of schizophrenia have resulted in ambiguous findings. The current study examined the association of schizophrenia with three COMT polymorphisms, namely, rs737865, rs4680, and rs165599 in a Greek population. There was no significant association between schizophrenia and any of the three SNPs examined. Howev

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