Academic literature on the topic 'RSA advisors/referents'

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Journal articles on the topic "RSA advisors/referents"

1

Carande, Robert. "Reference Advisory Systems (RAS): Some Practical Issues." Reference Services Review 17, no. 3 (1989): 87–90. http://dx.doi.org/10.1108/eb049069.

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2

Ambrogi, Federica. "Elisa Paini (1863-1924). Wife and «unbeatable collaborator» of Luigi Credaro." Rivista di Storia dell’Educazione 7, no. 2 (2020): 133–44. http://dx.doi.org/10.36253/rse-9865.

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The life of Luigi Credaro’s wife, Elisa Paini, allows us to observe some aspects of Credaro’s life in a new light. Through unpublished archival documents and letters of the spouses, the role of his wife is revealed, who was not only a trusted advisor but also a very reserved collaborator of the “Rivista Pedagogica” [Educational Journal] and the Unione Magistrale Nazionale, the Elementary school teachers national union. Elisa also represented the reference point for Credaro’s friends and colleagues and for anyone who wanted to reach him, to such an extent that she replaced her husband in his wr
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3

Walker, Christopher J., Junke Wang, Alyssa I. Clay-Gilmour, et al. "Meta-Analysis of Genome-Wide Association Studies of Acute Myeloid Leukemia (AML) Patients Identifies Variants Associated with Risk of 11q23/KMT2A-Translocated and Core-Binding Factor (CBF) AML and Suggests a Role for Transcription Elongation in Leukemogenesis." Blood 136, Supplement 1 (2020): 29–30. http://dx.doi.org/10.1182/blood-2020-141653.

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The first three authors contributed equally. The last three authors share senior authorship. Background: Although there has been an increased recognition of the contribution of germline variants to development of myeloid neoplasms, only two large-scale case-control genome-wide association studies (GWASs) have been conducted to identify variants that predispose to AML. Importantly, these studies were dedicated to AML predisposition in general, without investigation of molecularly distinct AML subtypes. Thus, we performed the first dedicated meta-analysis combining the two GWASs to investigate p
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4

Visconte, Valeria, Bartlomiej P. Przychodzen, Vera Adema, et al. "Development of a Novel Class of Agents Targeting the RNA-Splicing Machinery in Myeloid Malignancies." Blood 132, Supplement 1 (2018): 211. http://dx.doi.org/10.1182/blood-2018-99-116411.

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Abstract SF3B1 is a splicing factor gene whose mutations are pathognomonic of MDS with ring sideroblasts. Because of the ubiquitous importance of splicing, a major barrier in targeting cells with spliceosomal mutations is the discovery of agents decreasing the competitiveness of mutant cells while preserving the integrity of wild type cells. To date no specific therapies are FDA approved for SF3B1 mutant (SF3B1MT) MDS and few agents are in early clinical testing. We describe a novel targeted approach to drug development for SF3B1MT malignancies. Our investigative strategy started with a high t
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Yalniz, Fevzi F., Rima M. Saliba, Orhan K. Yucel, et al. "Somatic Mutations Improve Risk Classification By Cytogenetic Abnormalities in Patients with Myelodysplastic Syndrome after Hematopoietic Stem Cell Transplantation." Blood 134, Supplement_1 (2019): 512. http://dx.doi.org/10.1182/blood-2019-125937.

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Background: Hematopoietic stem cell transplantation (HSCT) offers potentially curative therapy for patients with myelodysplastic syndrome (MDS) but disease progression after HSCT remains a major reason for failure after transplant. Identification of risk factors for progression of MDS after HSCT would allow to identify target population for early initiation of preventive treatments to improve outcomes. Methods: Patients with a diagnosis of MDS who received first HSCT between 2013 and 2018 with available pre-transplant genetic profile obtained from next generation sequencing of genes were inclu
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Murphy, Tracy, Stanley W. K. Ng, Tong Zhang, et al. "Trial in Progress: Feasibility and Validation Study of the LSC17 Score in Acute Myeloid Leukemia Patients." Blood 134, Supplement_1 (2019): 2682. http://dx.doi.org/10.1182/blood-2019-130532.

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Background: AML is driven by a small subpopulation of leukemia stem cells (LSCs), which possess stem-cell properties such as quiescence and self-renewal that are linked to therapy resistance and relapse. The LSC17 score was derived from genes differentially expressed between functionally validated LSC+ and LSC- cell fractions from 78 AML patients. The LSC17 score was strongly associated with survival in 4 independent cohorts of AML patients treated with curative intent (n = 908), and accurately predicted initial response. Patients with high LSC17 scores had poor outcomes with standard treatmen
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Mahevas, Matthieu, Stephanie Guillet, Jean-Francois Viallard, et al. "Rate of Prolonged Response after Stopping Thrombopoietin-Receptor Agonists Treatment in Primary Immune Thrombocytopenia (ITP): Results from a Nationwide Prospective Multicenter Interventional Study (STOPAGO)." Blood 138, Supplement 1 (2021): 583. http://dx.doi.org/10.1182/blood-2021-152767.

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Abstract Background: Thrombopoietin receptor agonists(TPO-RAs) have been thought to play only a supporting role in ITP management. Several retrospective studies and a recent prospective study have reported unexpected cases of durable remission after TPO-RAs discontinuation in adult ITP in up to 30%. However, newly diagnosed ITP cases for which spontaneous remission may occur have been included in most of these studies. Thus, the main purpose of this study was to determine the proportion of patients with either persistent or chronic phase and no recent exposure to any potentially curative thera
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Tomaz, Victória, Karina Griesi-Oliveira, Renato D. Puga, Fabio Pires de Souza Santos, Nelson Hamerschlak, and Paulo Vidal Campregher. "Identification of Gene Networks Associated with the Anti-Leukemic Effect of Anti-Inflammatory Drugs on Acute Myeloid Leukemia Cell Lines." Blood 138, Supplement 1 (2021): 4343. http://dx.doi.org/10.1182/blood-2021-153903.

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Abstract Introduction Despite recent advances in therapy, acute myeloid leukemia (AML) remain a medical challenge with high morbidity and mortality rates. For most patients, allogeneic hematopoietic stem cell transplantation remain the only curative option, but due to the advanced age at diagnosis, a significant proportion of patients are not elegible to this form of therapy. Nevertheless, novel therapies are warranted. There is preclinical evidence that anti-inflammatory compounds, such as COX-2 inhibitors and steroids, may have anti-neoplastic activity in different tumor types, including AML
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Yao, Lijun, Reyka G. Jayasinghe, Beena E. Thomas, et al. "Integrated Cytof, Scrna-Seq and Cite-Seq Analysis of Bone Marrow Immune Microenvironment in the Mmrf Commpass Study." Blood 136, Supplement 1 (2020): 28–29. http://dx.doi.org/10.1182/blood-2020-142534.

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Compared with traditional bulk sequencing technologies, single-cell technologies have advantages to evaluate cellular heterogeneity and investigate the evolution of cellular subpopulations from the tumor and microenvironment. Application of single-cell sequencing in Multiple Myeloma (MM) is especially beneficial given MM is a highly heterogeneous disease with uncontrolled clonal expansion of plasma cells. Single-cell RNA sequencing (scRNA-seq) has been previously utilized to understand this hematopoietic malignancy in both tumor and immune populations in MM (Ledergor G. et al., 2018, Zavidij,
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10

Perumal, Deepak, Alessandro Lagana', Alex Rubinsteyn, et al. "Patient-Specific Mutation-Derived Tumor Antigens As Targets for Cancer Immunotherapy in Multiple Myeloma." Blood 126, no. 23 (2015): 1851. http://dx.doi.org/10.1182/blood.v126.23.1851.1851.

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Abstract Multiple myeloma (MM) is an incurable plasma cell malignancy accounting for more than 10,000 deaths in the US each year. Novel therapeutic approaches for relapsed MM are urgently needed. Tumor-specific mutations are ideal targets for cancer immunotherapy as they can be potentially recognized as neo-antigens by mature T-cells. Targeting tumor-specific antigens harboring somatic mutations presented on major histocompatibility complex class I molecules (MHC-I) with peptides could personalize the therapeutic approach for relapsed patients. To test this possibility, we examined 6 relapsed
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Dissertations / Theses on the topic "RSA advisors/referents"

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Gohin, Audrey. "Variabilité des pratiques professionnelles des conseillers/référents RSA. Le rôle de la représentation de l'employabilité, du sentiment de reconnaissance et des conflits de rôles et de valeurs perçus." Electronic Thesis or Diss., Toulouse 2, 2023. http://www.theses.fr/2023TOU20066.

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Depuis la sortie des Trente Glorieuses, les politiques de l’emploi et de lutte contre l’exclusion s’efforcent de résorber le chômage de masse (Zoberman, 2011). Aux échelles nationale et départementale, les dispositifs d’aide à l’insertion se multiplient et se succèdent. Cette diversité rend peu lisible le « maquis institutionnel » qui caractérise le secteur de l’insertion professionnelle (DARES, 2008) malgré une volonté gouvernementale de réduire ce millefeuille par la voie de « France Travail » (2023). Si nombre de travaux scientifiques se sont centrés sur la construction (Ebersold, 2005 ; Tr
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Books on the topic "RSA advisors/referents"

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Carande, Robert. Reference advisory systems (RAS): Some practical issues. 1989.

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Conference papers on the topic "RSA advisors/referents"

1

Twombly, Jeffrey G., Eric D. Cutright, and Kenneth K. Jackson. "Cost-Effective Risk Assessment of PTC Systems per FRA Rule 49CFR236 Subpart H." In 2009 Joint Rail Conference. ASMEDC, 2009. http://dx.doi.org/10.1115/jrc2009-63020.

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The US rail industry is charged with developing and implementing interoperable Positive Train Control (PTC) on many lines by 2015. It will be a challenge to assure the overall design safety of this next generation of train control, and there are significant issues with accommodating varying operating methods and different territories. The Federal Railroad Administration (FRA) will also require the railroads to meet the processor-based train control standards in FRA Rule 49CFR236 Sub-Part H (hereinafter FRA Rule 236H) [1], including the requirement for a comparative risk assessment, preferably
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