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Journal articles on the topic 'Rtl1'

Author: Grafiati

Published: 4 June 2021

Last updated: 9 February 2022

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1

Dini, Pouya, Mariano Carossino, Udeni B. R. Balasuriya, et al. "Paternally expressed retrotransposon Gag-like 1 gene, RTL1, is one of the crucial elements for placental angiogenesis in horses." Biology of Reproduction 104, no. 6 (2021): 1386–99. http://dx.doi.org/10.1093/biolre/ioab039.

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Abstract RTL1 (retrotransposon Gag-like 1) is an essential gene in the development of the human and murine placenta. Several fetal and placental abnormalities such as intrauterine growth restriction (IUGR) and hydrops conditions have been associated with altered expression of this gene. However, the function of RTL1 has not been identified. RTL1 is located on a highly conserved region in eutherian mammals. Therefore, the genetic and molecular analysis in horses could hold important implications for other species, including humans. Here, we demonstrated that RTL1 is paternally expressed and is

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Yu, Dawei, Jing Wang, Huiying Zou, et al. "Silencing of retrotransposon-derived imprinted gene RTL1 is the main cause for postimplantational failures in mammalian cloning." Proceedings of the National Academy of Sciences 115, no. 47 (2018): E11071—E11080. http://dx.doi.org/10.1073/pnas.1814514115.

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Substantial rates of fetal loss plague all in vitro procedures involving embryo manipulations, including human-assisted reproduction, and are especially problematic for mammalian cloning where over 90% of reconstructed nuclear transfer embryos are typically lost during pregnancy. However, the epigenetic mechanism of these pregnancy failures has not been well described. Here we performed methylome and transcriptome analyses of pig induced pluripotent stem cells and associated cloned embryos, and revealed that aberrant silencing of imprinted genes, in particular the retrotransposon-derived RTL1

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Kitazawa, Moe, Shinichiro Hayashi, Michihiro Imamura, et al. "Deficiency and overexpression of Rtl1 in the mouse cause distinct muscle abnormalities related to Temple and Kagami-Ogata syndromes." Development 147, no. 21 (2020): dev185918. http://dx.doi.org/10.1242/dev.185918.

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ABSTRACTTemple and Kagami-Ogata syndromes are genomic imprinting diseases caused by maternal and paternal duplication of human chromosome 14, respectively. They exhibit different postnatal muscle-related symptoms as well as prenatal placental problems. Using the mouse models for these syndromes, it has been demonstrated that retrotransposon gag like 1 [Rtl1, also known as paternally expressed 11 (Peg11)] located in the mouse orthologous imprinted region is responsible for the prenatal placental problems because it is an essential placental gene for maintenance of fetal capillary network during

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Fan, Guobiao, Dan Ye, Songcheng Zhu та ін. "RTL1 promotes melanoma proliferation by regulating Wnt/β-catenin signalling". Oncotarget 8, № 62 (2017): 106026–37. http://dx.doi.org/10.18632/oncotarget.22523.

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Davis, Erica, Florian Caiment, Xavier Tordoir, et al. "RNAi-Mediated Allelic trans-Interaction at the Imprinted Rtl1/Peg11 Locus." Current Biology 15, no. 8 (2005): 743–49. http://dx.doi.org/10.1016/j.cub.2005.02.060.

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Davis, Erica, Florian Caiment, Xavier Tordoir, et al. "RNAi-Mediated Allelic trans-Interaction at the Imprinted Rtl1/Peg11 Locus." Current Biology 15, no. 9 (2005): 884. http://dx.doi.org/10.1016/j.cub.2005.04.047.

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Leeton, L. A., and R. L. Tellam. "Adipogenesis in mouse 3T3L1 cells: the effects of Rtl1 over-expression." Functional & Integrative Genomics 7, no. 3 (2007): 257–61. http://dx.doi.org/10.1007/s10142-006-0042-3.

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Mahmoudi, Ahmad-Reza, Roya Ghods, Zahra Madjd, et al. "Expression profiling of RTL1 in human breast cancer tissues and cell lines." Experimental and Molecular Pathology 121 (August 2021): 104654. http://dx.doi.org/10.1016/j.yexmp.2021.104654.

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Fujioka, Kazumichi, Kosuke Nishida, Mariko Ashina, et al. "DNA methylation of the Rtl1 promoter in the placentas with fetal growth restriction." Pediatrics & Neonatology 60, no. 5 (2019): 512–16. http://dx.doi.org/10.1016/j.pedneo.2019.01.001.

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FANG, Yun-xia, Xiu-juan SONG, You-lin PENG, et al. "Characterization and Genetic Analysis of Rumpled and Twisted Leaf Mutant (rtl1) in Rice." Rice Science 18, no. 4 (2011): 243–49. http://dx.doi.org/10.1016/s1672-6308(12)60001-8.

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Xu, Xuewen, Fabien Ectors, Erica E. Davis, et al. "Ectopic Expression of Retrotransposon-Derived PEG11/RTL1 Contributes to the Callipyge Muscular Hypertrophy." PLOS ONE 10, no. 10 (2015): e0140594. http://dx.doi.org/10.1371/journal.pone.0140594.

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Cui, Xiang-Shun, Ding-Xiao Zhang, Yoeung-Gyu Ko, and Nam-Hyung Kim. "Aberrant epigenetic reprogramming of imprinted microRNA-127 and Rtl1 in cloned mouse embryos." Biochemical and Biophysical Research Communications 379, no. 2 (2009): 390–94. http://dx.doi.org/10.1016/j.bbrc.2008.12.148.

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Riordan, Jesse D., Vincent W. Keng, Barbara R. Tschida, et al. "Identification of Rtl1, a Retrotransposon-Derived Imprinted Gene, as a Novel Driver of Hepatocarcinogenesis." PLoS Genetics 9, no. 4 (2013): e1003441. http://dx.doi.org/10.1371/journal.pgen.1003441.

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Ito, M., A. N. Sferruzzi-Perri, C. A. Edwards, et al. "A trans-homologue interaction between reciprocally imprinted miR-127 and Rtl1 regulates placenta development." Development 142, no. 14 (2015): 2425–30. http://dx.doi.org/10.1242/dev.121996.

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Boyle, Michael J., Vano Baghdassarian, Stanislaw M. Stepkowski, Lynette J. Dumble, and Barry D. Kahan. "Intrasplenic Liver Parenchymal Cells in Conjunction with Low-Dose Rapamycin and Cyclosporine Induce a Unique and Specific Prolongation of Rat Cardiac and Small Bowel Allograft Survival." Cell Transplantation 7, no. 3 (1998): 247–56. http://dx.doi.org/10.1177/096368979800700303.

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These experiments investigated the immunosuppressive properties of liver tissue. Brown Norway (BN; RT1n) rat heart allografts survived in untreated control Wistar Furth (WFu; RTlu) rat recipients for 6.2 ± 1.5 days, while allografts in animals that received rapamycin (RAPA) 0.0075 mg/kg/day and cyclosporine (CsA) 0.375 mg/kg/day delivered for 14 days by continuous intravenous infusion (civi) using osmotic pumps in conjunction with intrasplenic (i.s.) saline survived to 18.4 ± 1.3 days. i.s. addition of 3 M-KCl extracted BN hepatic antigen or unpurified BN hepatocytes (liver parenchymal cells—5

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Sekita, Yoichi, Hirotaka Wagatsuma, Kenji Nakamura, et al. "Role of retrotransposon-derived imprinted gene, Rtl1, in the feto-maternal interface of mouse placenta." Nature Genetics 40, no. 2 (2008): 243–48. http://dx.doi.org/10.1038/ng.2007.51.

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YANG, Zong-lin, Huan-chen CHENG, Qing-you XIA, Cao-de JIANG, Chang-yan DENG, and Yue-min LI. "Imprinting Analysis of RTL1 and DIO3 Genes and Their Association with Carcass Traits in Pigs (Sus scrofa)." Agricultural Sciences in China 8, no. 5 (2009): 613–19. http://dx.doi.org/10.1016/s1671-2927(08)60253-9.

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18

Fleming-Waddell, Jolena N., Gayla R. Olbricht, Tasia M. Taxis, et al. "Effect of DLK1 and RTL1 but Not MEG3 or MEG8 on Muscle Gene Expression in Callipyge Lambs." PLoS ONE 4, no. 10 (2009): e7399. http://dx.doi.org/10.1371/journal.pone.0007399.

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19

Petschick, Lara, Sascha Bub, Jakob Wolfram, Sebastian Stehle, and Ralf Schulz. "Modeling Regulatory Threshold Levels for Pesticides in Surface Waters from Effect Databases." Data 4, no. 4 (2019): 150. http://dx.doi.org/10.3390/data4040150.

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Regulatory threshold levels (RTL) represent robust benchmarks for assessing risks of pesticides, e.g., in surface waters. However, comprehensive scientific risk evaluations comparing RTL to measured environmental concentrations (MEC) of pesticides in surface waters were yet restricted to a low number of pesticides, as RTL are only available after extensive review of regulatory documents. Thus, the aim of the present study was to model RTL equivalents (RTLe) for aquatic organisms from publicly accessible ecotoxicological effect databases. We developed a model that applies validity criteria in a

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Prasasya, Rexxi, Kristen V. Grotheer, Linda D. Siracusa, and Marisa S. Bartolomei. "Temple syndrome and Kagami-Ogata syndrome: clinical presentations, genotypes, models and mechanisms." Human Molecular Genetics 29, R1 (2020): R107—R116. http://dx.doi.org/10.1093/hmg/ddaa133.

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Abstract Temple syndrome (TS) and Kagami-Ogata syndrome (KOS) are imprinting disorders caused by absence or overexpression of genes within a single imprinted cluster on human chromosome 14q32. TS most frequently arises from maternal UPD14 or epimutations/deletions on the paternal chromosome, whereas KOS most frequently arises from paternal UPD14 or epimutations/deletions on the maternal chromosome. In this review, we describe the clinical symptoms and genetic/epigenetic features of this imprinted region. The locus encompasses paternally expressed protein-coding genes (DLK1, RTL1 and DIO3) and

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Charbonnel, Cyril, Adnan K. Niazi, Emilie Elvira-Matelot, et al. "The siRNA suppressor RTL1 is redox-regulated through glutathionylation of a conserved cysteine in the double-stranded-RNA-binding domain." Nucleic Acids Research 45, no. 20 (2017): 11891–907. http://dx.doi.org/10.1093/nar/gkx820.

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Byrne, Keren, Michelle L. Colgrave, Tony Vuocolo, et al. "The Imprinted Retrotransposon-Like Gene PEG11 (RTL1) Is Expressed as a Full-Length Protein in Skeletal Muscle from Callipyge Sheep." PLoS ONE 5, no. 1 (2010): e8638. http://dx.doi.org/10.1371/journal.pone.0008638.

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Kitazawa, Moe, Akito Sutani, Tomoko Kaneko‐Ishino, and Fumitoshi Ishino. "The role of eutherian‐specific RTL1 in the nervous system and its implications for the Kagami‐Ogata and Temple syndromes." Genes to Cells 26, no. 3 (2021): 165–79. http://dx.doi.org/10.1111/gtc.12830.

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Figueiredo, Constança, Dirk Wedekind, Thomas Müller, et al. "MHC Universal Cells Survive in an Allogeneic Environment after Incompatible Transplantation." BioMed Research International 2013 (2013): 1–12. http://dx.doi.org/10.1155/2013/796046.

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Cell, tissue, and organ transplants are commonly performed for the treatment of different diseases. However, major histocompatibility complex (MHC) diversity often prevents complete donor-recipient matching, resulting in graft rejection. This study evaluates in a preclinical model the capacity of MHC class I-silenced cells to engraft and grow upon allogeneic transplantation. Short hairpin RNA targetingβ2-microglobulin (RN_shβ2m) was delivered into fibroblasts derived from LEW/Ztm (RT1l) (RT1-Al) rats using a lentiviral-based vector. MHC class I (RT1-A-) expressing and -silenced cells were inje

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Birzu, C., A. Hillairet, M. Giry, et al. "OS9.7 Telomere length, TERTp mutation and ALT status in adult diffuse gliomas." Neuro-Oncology 21, Supplement_3 (2019): iii19—iii20. http://dx.doi.org/10.1093/neuonc/noz126.065.

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Abstract BACKGROUND The current classification of adult diffuse gliomas integrates two alternative telomere maintenance mechanisms: reactivation of telomerase activity by TERT promoter (TERTp) mutations or ATRX mutations associated with alternative length telomere (ALT). We investigated here the relation between these two mechanisms, telomere length, and outcome in a large series of diffuse gliomas. MATERIAL AND METHODS We performed C-circle assay (CCA) to determine ALT status, determined telomere length in tumor (RTLt) and leukocyte (RTLl) in a cohort of 354 adult diffuse gliomas, and sequenc

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Fangmann, J., R. Dalchau, and J. W. Fabre. "Rejection of skin allografts by indirect allorecognition of donor class I major histocompatibility complex peptides." Journal of Experimental Medicine 175, no. 6 (1992): 1521–29. http://dx.doi.org/10.1084/jem.175.6.1521.

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LEW (RT1l) rats were immunized with peptides corresponding to the alpha helical region of the alpha 1 domain (peptide 1), the beta sheet of the alpha 2 domain (peptide 2), and the alpha helical region of the alpha 2 domain (peptide 3) of the RT1-Aav1 classical class I molecule of the DA (RT1av1) strain. The immunizations were without carriers, and the objective was to prime to indirect allorecognition without influencing direct recognition of the RT1-Aav1 molecule. The LEW rats mounted strong primary and secondary antibody responses to peptides 1 and 3, but only weak secondary responses to pep

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O'Kane, Grainne, Sarah A. McGarrigle, Nadia Rehill, et al. "Levels of oxidative stress and telomeres in Lynch syndrome-associated malignancies." Journal of Clinical Oncology 34, no. 4_suppl (2016): 582. http://dx.doi.org/10.1200/jco.2016.34.4_suppl.582.

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582 Background: Lynch Syndrome (LS) is caused by germline mutations in mismatch repair genes (MMR) genes which are critical in maintaining cellular integrity. Failure of the MMR pathway in LS culminates in the hypermutable phenotype of Microsatellite Instability. LS confers an increased risk of malignancy of which colorectal cancer (CRC) is most common. Carriers exhibit significant phenotypic variation in the age of onset of malignancy which cannot be predicted. Telomere length attrition is considered an early step in carcinogenesis and may be accelerated by oxidative stress. We investigated a

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Chakraborty, Sujata, C. L. Sun, L. Francisco, et al. "Rapid Telomere Loss in Hematopoietic Cells Associated with Development of t-MDS after Autologous Transplantation for Lymphoma." Blood 108, no. 11 (2006): 2644. http://dx.doi.org/10.1182/blood.v108.11.2644.2644.

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Abstract Therapy-related MDS (t-MDS) is a lethal complication of autologous hematopoietic cell transplantation (HCT) for Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL). Although t-MDS is known to result from damage to hematopoietic stem cells (HSC) from genotoxic cancer treatment, the sequential cellular and molecular changes leading to its development are not known. To better understand t-MDS pathogenesis we are conducting a prospective study of a cohort of patients undergoing autologous HCT for HL and NHL. Patients are followed longitudinally from pre-HCT to 5 yrs post-HCT, with serial

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Morita, Augusto Ken, Rubens Takiguti, and Wilhelmus A. M. Van Noije. "Metadata based padring and pad multiplexing generation for microcontroller design." Journal of Integrated Circuits and Systems 10, no. 3 (2015): 139–46. http://dx.doi.org/10.29292/jics.v10i3.416.

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Defining padring and its pad interconnections is one of the most time consuming steps of a microcontroller SoC design. Also, multiple device features plus testability in limited pinout packages entails more functions shared per pin. As such, the number of padring connections and complexity exponentially grows at each new design. This paper describes a methodology to configure pad connections and select correct pad cells. The methodology works out technology and function definitions for each pin using new and previous designs data stored in a metadata database in order to generate the padring R

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Stehle, Sebastian, and Ralf Schulz. "Agricultural insecticides threaten surface waters at the global scale." Proceedings of the National Academy of Sciences 112, no. 18 (2015): 5750–55. http://dx.doi.org/10.1073/pnas.1500232112.

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Compared with nutrient levels and habitat degradation, the importance of agricultural pesticides in surface water may have been underestimated due to a lack of comprehensive quantitative analysis. Increasing pesticide contamination results in decreasing regional aquatic biodiversity, i.e., macroinvertebrate family richness is reduced by ∼30% at pesticide concentrations equaling the legally accepted regulatory threshold levels (RTLs). This study provides a comprehensive metaanalysis of 838 peer-reviewed studies (>2,500 sites in 73 countries) that evaluates, for the first time to our knowledg

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King, Kevin, John Quarles, Vaishnavi Ravi, et al. "The Impact of a Location-Sensing Electronic Health Record on Clinician Efficiency and Accuracy: A Pilot Simulation Study." Applied Clinical Informatics 09, no. 04 (2018): 841–48. http://dx.doi.org/10.1055/s-0038-1675812.

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Background Through the Health Information Technology for Economic and Clinical Health Act of 2009, the federal government invested $26 billion in electronic health records (EHRs) to improve physician performance and patient safety; however, these systems have not met expectations. One of the cited issues with EHRs is the human–computer interaction, as exhibited by the excessive number of interactions with the interface, which reduces clinician efficiency. In contrast, real-time location systems (RTLS)—technologies that can track the location of people and objects—have been shown to increase cl

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Cao, Qing-Fu, Junichi Yamamoto, Tomoyasu Isobe, et al. "Characterization of the Human Transcription Elongation Factor Rtf1: Evidence for Nonoverlapping Functions of Rtf1 and the Paf1 Complex." Molecular and Cellular Biology 35, no. 20 (2015): 3459–70. http://dx.doi.org/10.1128/mcb.00601-15.

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Restores TBP function 1 (Rtf1) is generally considered to be a subunit of the Paf1 complex (PAF1C), a multifunctional protein complex involved in histone modification and transcriptional or posttranscriptional regulation. Rtf1, however, is not stably associated with the PAF1C in most species exceptSaccharomyces cerevisiae, and its biochemical functions are not well understood. Here, we show that human Rtf1 is a transcription elongation factor that may function independently of the PAF1C. Rtf1 requires “Rtf1 coactivator” activity, which is most likely unrelated to the PAF1C or DSIF, for transcr

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Limoges, Jacqueline, Sara Lankshear, and Joseph Church. "Real time location systems: Is it big brother or a big opportunity for professional practice?" Journal of Nursing Education and Practice 10, no. 11 (2020): 67. http://dx.doi.org/10.5430/jnep.v10n11p67.

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Purpose: Real Time Location Systems (RTLS) is an emerging health care technology with the potential to capture data that can be used to improve professional practice and patient outcomes. However, there is a paucity of literature in this area to guide health professionals and leaders in both the implementation and use of RTLS data. To address this gap in the literature, this qualitative study was designed to explore how staff perceive and experience RTLS, and how health care providers anticipate using RTLS data for professional practice and clinical decision making.Results: Interviews and focu

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Mayekar, Manasi K., Richard G. Gardner, and Karen M. Arndt. "The Recruitment of theSaccharomyces cerevisiaePaf1 Complex to Active Genes Requires a Domain of Rtf1 That Directly Interacts with the Spt4-Spt5 Complex." Molecular and Cellular Biology 33, no. 16 (2013): 3259–73. http://dx.doi.org/10.1128/mcb.00270-13.

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Transcription elongation factors associate with RNA polymerase II and aid its translocation through chromatin. One such factor is the conserved Paf1 complex (Paf1C), which regulates gene expression through several mechanisms, including the stimulation of cotranscriptional histone modifications. Previous studies revealed a prominent role for the Rtf1 subunit in tethering Paf1C to the RNA polymerase II elongation machinery. Here, we investigated the mechanism by which Rtf1 couples Paf1C to active chromatin. We show that a highly conserved domain of Rtf1 is necessary and sufficient for mediating

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Yang, Ming-Yu, Jan-Gowth Chang, Pai-Mei Lin, et al. "Altered Regulation of Imprinted Non-Coding RNA Genes in Acute Myeloid Leukemia,." Blood 118, no. 21 (2011): 3456. http://dx.doi.org/10.1182/blood.v118.21.3456.3456.

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Abstract Abstract 3456 Studies in large-scale genome sequencing have shown that only 2% of the mammalian genome encodes mRNAs, but the most part is transcribed as long and short non-coding RNAs (ncRNAs). The ncRNAs with gene regulatory functions are starting to be seen as a common feature of mammalian gene regulation. Genomic imprinting is a form of epigenetic regulation and imprinted genes are silenced in a parental-specific manner. Imprinted genes tend to occur in clusters and ncRNAs have been found at all well-characterized imprinted clusters. Although the exact mechanism how imprinted ncRN

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Horimoto, Hitoshi, Masumi Nozawa, Norihiro Kokudo, et al. "Immunoregulation via Adhesion Molecules in Allogenic and Xenogenic Hepatocyte Transplantation to Nagase's Analbuminemic Rats." Cell Transplantation 6, no. 5 (1997): 535–36. http://dx.doi.org/10.1177/096368979700600517.

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We investigated the effects of monoclonal antibodies (mAbs) against lymphocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1) on intrasplenic allogenic and xenogenic hepatocyte transplantation (HCTx) to analbuminemic rats. Ten to 12-wk-old male Nagase's analbuminemic rats (RT1l) were used as recipients, Wistar/Shi rats (RTlk) were used as donors for allografts and BALB/C mice were used as donors for xenografts. The experimental groups were as follows: group 1, allo-HCTx (n = 7); group 2, allo-HCTx + antirat ICAM-1/antirat LFA-1 mAbs (1.0 mg/kg/day, for 7 d

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Petty, Emily L., Masha Evpak, and Lorraine Pillus. "ConnectingGCN5’s centromeric SAGA to the mitotic tension-sensing checkpoint." Molecular Biology of the Cell 29, no. 18 (2018): 2201–12. http://dx.doi.org/10.1091/mbc.e17-12-0701.

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Multiple interdependent mechanisms ensure faithful segregation of chromosomes during cell division. Among these, the spindle assembly checkpoint monitors attachment of spindle microtubules to the centromere of each chromosome, whereas the tension-sensing checkpoint monitors the opposing forces between sister chromatid centromeres for proper biorientation. We report here a new function for the deeply conserved Gcn5 acetyltransferase in the centromeric localization of Rts1, a key player in the tension-sensing checkpoint. Rts1 is a regulatory component of protein phopshatase 2A, a near universal

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Costa, Patrick J., and Karen M. Arndt. "Synthetic Lethal Interactions Suggest a Role for the Saccharomyces cerevisiae Rtf1 Protein in Transcription Elongation." Genetics 156, no. 2 (2000): 535–47. http://dx.doi.org/10.1093/genetics/156.2.535.

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Abstract Strong evidence indicates that transcription elongation by RNA polymerase II (pol II) is a highly regulated process. Here we present genetic results that indicate a role for the Saccharomyces cerevisiae Rtf1 protein in transcription elongation. A screen for synthetic lethal mutations was carried out with an rtf1 deletion mutation to identify factors that interact with Rtf1 or regulate the same process as Rtf1. The screen uncovered mutations in SRB5, CTK1, FCP1, and POB3. These genes encode an Srb/mediator component, a CTD kinase, a CTD phosphatase, and a protein involved in the regula

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Ritohardoyo, Su, and Mohammad Isnaini Sadali. "KESESUAIAN KEBERADAAN RUMAH TIDAK LAYAK HUNI (RTLH) TERHADAP TATA RUANG WILAYAH DI KOTA YOGYAKARTA." TATALOKA 19, no. 4 (2017): 291. http://dx.doi.org/10.14710/tataloka.19.4.291-305.

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Residence is one of the basic rights of every person, meaning that every citizen has the right to reside and got a decent living environment. But in reality, not everyone can get a place to stay that is livable. This has been, is, and will became always a problem for communities and governments in developing residential areas with proper environmental quality. Therefore, this paper presents the results of research that aims to: (1) identification and mapping out where residence were un-inhabitable (RTLH); (2) analysis of the suitability of the location RTLH the spatial plan; and (3) analysis R

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Oude Weernink, C. E., E. Felix, P. J. E. M. Verkuijlen, A. T. M. Dierick-van Daele, J. K. Kazak, and J. van Hoof. "Real-time location systems in nursing homes: state of the art and future applications." Journal of Enabling Technologies 12, no. 2 (2018): 45–56. http://dx.doi.org/10.1108/jet-11-2017-0046.

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PurposeIn the domain of healthcare, both process efficiency and the quality of care can be improved through the use of dedicated pervasive technologies. Among these applications are so-called real-time location systems (RTLS). Such systems are designed to determine and monitor the location of assets and people in real time through the use of wireless sensor networks. Numerous commercially available RTLS are used in hospital settings. The nursing home is a relatively unexplored context for the application of RTLS and offers opportunities and challenges for future applications. The paper aims to

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Henckel, Ewa, Anna James, Jon R. Konradsen, et al. "A Novel Association between YKL-40, a Marker of Structural Lung Disease, and Short Telomere Length in 10-Year-Old Children with Bronchopulmonary Dysplasia." Children 8, no. 2 (2021): 80. http://dx.doi.org/10.3390/children8020080.

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Extremely preterm infants are born with immature lungs and are exposed to an inflammatory environment as a result of oxidative stress. This may lead to airway remodeling, cellular aging and the development of bronchopulmonary dysplasia (BPD). Reliable markers that predict the long-term consequences of BPD in infancy are still lacking. We analyzed two biomarkers of cellular aging and lung function, telomere length and YKL-40, respectively, at 10 years of age in children born preterm with a history of BPD (n = 29). For comparison, these markers were also evaluated in sex-and-age-matched children

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Stolinski, L. A., D. M. Eisenmann, and K. M. Arndt. "Identification of RTF1, a novel gene important for TATA site selection by TATA box-binding protein in Saccharomyces cerevisiae." Molecular and Cellular Biology 17, no. 8 (1997): 4490–500. http://dx.doi.org/10.1128/mcb.17.8.4490.

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Interaction of the TATA box-binding protein (TBP) with promoters of RNA polymerase II-transcribed genes is an early and essential step in mRNA synthesis. Previous studies have demonstrated that the rate-limiting binding of TBP to a TATA element can be influenced by transcriptional regulatory proteins. To identify additional factors that may regulate DNA binding by TBP in vivo, we performed a genetic selection for extragenic suppressors of a yeast TBP mutant that exhibits altered and relaxed DNA binding specificity. This analysis has led to the discovery of a previously unidentified gene, RTF1.

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SEMBA, Shogo, Hiroshi SAITO, Masato TATSUOKA, and Katsuya FUJIMURA. "Optimization Methods during RTL Conversion from Synchronous RTL Models to Asynchronous RTL Models." IEICE Transactions on Fundamentals of Electronics, Communications and Computer Sciences E103.A, no. 12 (2020): 1417–26. http://dx.doi.org/10.1587/transfun.2020vlp0004.

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Gutierrez-Rodrigues, Fernanda, Sachiko Kajigaya, Xingmin Feng, et al. "Heterozygous RTEL1 variants in Patients with Bone Marrow Failure Associate with Telomere Dysfunction in the Absence of Telomere Shortening." Blood 128, no. 22 (2016): 1044. http://dx.doi.org/10.1182/blood.v128.22.1044.1044.

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Abstract The pathophysiology of bone marrow failure (BMF) can be immune, as in acquired aplastic anemia (AA), or constitutional, due to germline mutations in genes critical for DNA repair and telomere maintenance. Variability in penetrance and phenotype can complicate diagnosis, as patients with underlying genetic defects may present in adulthood and without characteristic physical anomalies. RTEL1 encodes a helicase crucial for telomere maintenance and DNA repair. The gene has two main transcripts in human cells: the 1300 amino acid isoform 3 and the 1219 amino acid isoform 1. RTEL1 isoform 3

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Hamdi, Khairil, Budi Sunaryo, Arianto Arianto, Yuhefizar, and Imam Gunawan. "Sistem Pelacakan Lokasi Petugas Survei RTLH Menggunakan GPS Android dan WebGIS." Jurnal RESTI (Rekayasa Sistem dan Teknologi Informasi) 3, no. 3 (2019): 552–59. http://dx.doi.org/10.29207/resti.v3i3.1355.

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The feasibility of a home for family residence is the basis for growing and developing a better family life. The roof, floor, and walls are data on the indicator of the feasibility of the house at the time of the survey. The need for a system that can display RTLH locations in the Web Geographic Information System (WebGIS) accompanied by detailed RTLH data and photos. This study explains how the system tracks the location of RTLH survey data officers using Android GPS, then represents it on WebGIS. The tracking method starts when the clerk fills out the home data input form via the Android app

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Nahas, SJ, WB Young, R. Terry, et al. "Right-to-left shunt is common in chronic migraine." Cephalalgia 30, no. 5 (2009): 535–42. http://dx.doi.org/10.1111/j.1468-2982.2009.02002.x.

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Our aim was to determine the prevalence of right-to-left shunt (RtLS) in patients with chronic migraine (CM), and to correlate the presence and grade of RtLS with aura and neurological symptoms, and duration and severity of disease. The prevalence of RtLS in migraine without aura is similar to that of the general population (between 20 and 35%). In migraine with aura, the prevalence is much higher (approximately 50%). The prevalence in CM, with or without aura, is unknown. Consecutive patients between the ages of 18 and 60 years with CM attending a tertiary care specialty headache clinic over

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Ryu, Ji-yeon, Yoonseong Choi, Kun-Hwa Hong, Yong Suk Chung, and Somi Kim Cho. "Effect of Roasting and Brewing on the Antioxidant and Antiproliferative Activities of Tartary Buckwheat." Foods 9, no. 9 (2020): 1331. http://dx.doi.org/10.3390/foods9091331.

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We evaluated the effect of the roasting and brewing conditions of Tartary buckwheat (TB), which is widely used in infusion teas, on its antioxidant and antiproliferative activities in vitro. TB was roasted at 210 °C for 10 min and brewed at a high temperature for a short time (HTST; 85–90 °C, 3 min) or at room temperature for a long time (RTLT; 25–30 °C, 24 h). Roasted TB (RTB) tea brewed at RTLT had the highest total polyphenol content (TPC) and total flavonoid content (TFC) among the four TB teas for different roasting and brewing conditions. Moreover, RTB brewed at RTLT showed the greatest

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Warner, Marcie H., Kelli L. Roinick, and Karen M. Arndt. "Rtf1 Is a Multifunctional Component of the Paf1 Complex That Regulates Gene Expression by Directing Cotranscriptional Histone Modification." Molecular and Cellular Biology 27, no. 17 (2007): 6103–15. http://dx.doi.org/10.1128/mcb.00772-07.

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ABSTRACT Numerous transcription accessory proteins cause alterations in chromatin structure that promote the progression of RNA polymerase II (Pol II) along open reading frames (ORFs). The Saccharomyces cerevisiae Paf1 complex colocalizes with actively transcribing Pol II and orchestrates modifications to the chromatin template during transcription elongation. To better understand the function of the Rtf1 subunit of the Paf1 complex, we created a series of sequential deletions along the length of the protein. Genetic and biochemical assays were performed on these mutants to identify residues r

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Ho, Hanley J., Zoe Xiaozhu Zhang, Zhilian Huang, Aung Hein Aung, Wei-Yen Lim, and Angela Chow. "Use of a Real-Time Locating System for Contact Tracing of Health Care Workers During the COVID-19 Pandemic at an Infectious Disease Center in Singapore: Validation Study." Journal of Medical Internet Research 22, no. 5 (2020): e19437. http://dx.doi.org/10.2196/19437.

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Background In early 2020, coronavirus disease (COVID-19) emerged and spread by community and nosocomial transmission. Effective contact tracing of potentially exposed health care workers is crucial for the prevention and control of infectious disease outbreaks in the health care setting. Objective This study aimed to evaluate the comparative effectiveness of contact tracing during the COVID-19 pandemic through the real-time locating system (RTLS) and review of the electronic medical record (EMR) at the designated hospital for COVID-19 response in Singapore. Methods Over a 2-day study period, a

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Kakinuma, M., W. R. Tang, Y. Arimura, T. Koda, and M. Kishi. "Organization of RT1-DOa and RT1-DOb loci." Transplantation Proceedings 29, no. 3 (1997): 1670. http://dx.doi.org/10.1016/s0041-1345(97)00009-2.

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