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Journal articles on the topic 'Rumen-protected niacin'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Alfaro, Gastón F., Valentino Palombo, Mariasilvia D’Andrea, et al. "Hepatic transcript profiling in beef cattle: Effects of rumen-protected niacin supplementation." PLOS ONE 18, no. 8 (2023): e0289409. http://dx.doi.org/10.1371/journal.pone.0289409.

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The objective of our study was to assess the effect of rumen-protected niacin supplementation on the transcriptome of liver tissue in growing Angus × Simmental steers and heifers through RNA-seq analysis. Consequently, we wanted to assess the known role of niacin in the physiological processes of vasodilation, detoxification, and immune function in beef hepatic tissue. Normal weaned calves (~8 months old) were provided either a control diet or a diet supplemented with rumen-protected niacin (6 g/hd/d) for a 30-day period, followed by a liver biopsy. We observed a significant list of changes at

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2

J Moisá, Sonia. "Evaluation of Alterations in Uterine Blood Flow using Doppler Ultrasonography in Pregnant, Genotyped Beef Cows and Heifers Consuming Endophyte-Infected Tall Fescue Seeds and Supplemented with Rumen-Protected Niacin." Open Access Journal of Veterinary Science & Research 6, no. 1 (2021): 1–8. http://dx.doi.org/10.23880/oajvsr-16000207.

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Fescue toxicity is a nutritional-related disease generated in a forage-based beef herd exposed to ergot alkaloids (i.e. ergovaline) present in endophyte-infected tall fescue that produces important economic losses. The combination of a genetic test for susceptibility to fescue toxicity and supplementation with rumen-protected niacin could potentially reduce the toxic effects of ergovaline on beef cow and heifers’ reproductive performance during mid-gestation by improving uterine blood flow. Our main objective was to use color Doppler ultrasonography to evaluate the occurrence of any alteration

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3

Chen, Juncai, Zhenguo Yang, and Guozhong Dong. "Niacin nutrition and rumen-protected niacin supplementation in dairy cows: an updated review." British Journal of Nutrition 122, no. 10 (2019): 1103–12. http://dx.doi.org/10.1017/s0007114519002216.

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AbstractAs the precursor to NAD+ and NADP+, niacin is important for catabolic and anabolic redox reactions. In addition, niacin is known for its anti-lipolytic action via a hydroxycarboxylic acid-2-receptor-dependent mechanism. The anti-lipolytic effects of traditional free niacin supplementation during transition periods had been studied extensively, but the reported effects are ambiguous. In the past decade, a series of studies were conducted to evaluate the effects of rumen-protected niacin (RPN) on production performance and metabolic status in early lactation and on heat stress in dairy c

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4

Zhang, Yuanjie, Rongrong Li, Xue’er Du, et al. "Transcriptome in Liver of Periparturient Dairy Cows Differs between Supplementation of Rumen-Protected Niacin and Rumen-Protected Nicotinamide." Metabolites 14, no. 3 (2024): 150. http://dx.doi.org/10.3390/metabo14030150.

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To investigate the difference between rumen-protected niacin (RPN) and rumen-protected nicotinamide (RPM) in the transcriptome of genes relating to the lipid metabolism of the liver of periparturient dairy cows, 10 healthy Chinese Holstein cows were randomly divided into two groups and fed diets supplemented with 18.4 g/d RPN or 18.7 g/d RPM, respectively. The experiment lasted from 14 days before to 21 days after parturition. Liver biopsies were taken 21 days postpartum for transcriptomic sequencing. In addition, human LO2 cells were cultured in a medium containing 1.6 mmol/L of non-esterifie

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5

Chaudhary, Sandhya Sunil, Virendra Kumar Singh, Tanvi Dharmabhai Manat, Sanjay Bhagubhai Patel, and Navin Babulal Patel. "Heat ameliorative effects of rumen protected niacin supplementation in lactating Surti buffaloes." Buffalo Bulletin 41, no. 4 (2022): 773. http://dx.doi.org/10.56825/bufbu.2022.4144683.

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Niacin may cause evaporative thermolysis through cutaneous hyperemia, vasodilation, increased sweating rate and decreased skin temperature. It is antilipolytic and can improve metabolic responses. Heat stress ameliorative effects of rumen protected niacin (RPN) supplementation in lactating Surti buffaloes during summer has been investigated in present study. Fourteen lactating Surti buffaloes were divided into two groups (Control-T1, N=7; RPN-T2, N=7). T2 (RPN) group was supplemented with RPN 6 g/ animal/ day in two divided dose for 4 weeks. Meteorological, physiological, sweating rate and ski

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6

Gao, Yanxia, Jianguo Li, Wenbin Jia, Qiufeng Li, and Yufeng Cao. "Response of lactating cows to supplemental rumen protected methionine and Niacin." Frontiers of Agriculture in China 2, no. 1 (2008): 121–24. http://dx.doi.org/10.1007/s11703-008-0021-7.

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7

Hashemian, K., M. A. Norouzian, and A. Mohammadi-Sangcheshmeh. "Dietary supplemental chromium and niacin influence the growth performance and fat deposition in lambs." Animal Production Science 60, no. 5 (2020): 618. http://dx.doi.org/10.1071/an18717.

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Context Nowadays fat is an unpopular constituent of meat for consumers and therefore, a decrease in fat-tail size is often desirable for producers. Feed additives like chromium (Cr) and niacin (B3) have been reported to improve meat quality in beef and dairy cattle. However, their effect on meat quality and performance of fat-tail breeds of finishing lambs is unknown. Aim The aim of this study was to investigate the effect of supplemental chromium (Cr) and niacin (B3) on performance and fat deposition of carcass of finishing lambs. Methods Twenty male Zandi lambs (23.7 ± 0.73 kg) were allocate

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8

Alfaro, Gaston F., Sandra L. Rodriguez-Zas, Bruce R. Southey, et al. "Complete Blood Count Analysis on Beef Cattle Exposed to Fescue Toxicity and Rumen-Protected Niacin Supplementation." Animals 11, no. 4 (2021): 988. http://dx.doi.org/10.3390/ani11040988.

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Offspring born to dams genetically tested for resistance to fescue toxicity were separated in groups based on their dams’ resistance level (tolerant vs. susceptible). Rumen-protected niacin (RPN) is proposed as a potential alleviator for vasoconstriction produced by fescue toxicity. Complete blood count (CBC) analysis was utilized for detection of significant responses to treatments applied. Our objectives were as follows: (a) to analyze changes in CBC due to fescue toxicity, maternal resistance level, and RPN in growing offspring; and (b) to assess the effects of maternal resistance level whe

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9

Alfaro, Gastón F., Russell Muntifering, Soren P. Rodning, et al. "75 Effects of endophyte-infected tall fescue on performance of genotyped pregnant beef cows and heifers supplemented with rumen-protected niacin." Journal of Animal Science 98, Supplement_4 (2020): 47–48. http://dx.doi.org/10.1093/jas/skaa278.087.

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Abstract Fescue toxicity is the result of cattle consuming fungal (Ergot spp.) endophyte tall fescue, a perennial forage widely used in the United States. Ergot alkaloids produce vasoconstriction; however, rumen-protected Niacin (RPN), known by its vasodilation ability, may act as an alleviator for fescue toxicity. Our objective was to assess the effects of a genetic test for fescue toxicity susceptibility, and RPN supplementation on animal performance, hepatic gene expression, and uterine arteries blood flow of Angus × Simmental pregnant animals consuming endophyte-infected tall fescue seeds.

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10

Youssef, Mohamed A., Maged R. El-Ashker, and Marwa S. Younis. "Effect of prepartum supplementation with niacin, choline and cod liver oil on postpartum insulin sensitivity and the redox status in cows with subclinical ketosis." Animal Production Science 58, no. 10 (2018): 1847. http://dx.doi.org/10.1071/an16842.

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There have been limited field trials exploring the potential ameliorative effect of B-complex vitamin or antioxidant therapy in cows with prolonged insulin resistance (IR). The purpose of this study was to explore the effect of prepartum supplementation of niacin, choline and cod liver oil on metabolic status, indices of insulin sensitivity (IS) as well as markers of oxidative stress in cows with subclinical ketosis (SCK). For this purpose, 24 apparently healthy cows at ~3 weeks before the expected time of calving were studied. Based on their serum concentration of non-esterified fatty acid (N

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11

Middlemass, C. A., C. M. Minter, and M. Marsden. "Response of early lactation dairy cows to the inclusion of the liver technology product ABN-LiFT in the total mixed ration." Proceedings of the British Society of Animal Science 2002 (2002): 197. http://dx.doi.org/10.1017/s175275620000853x.

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Through the dry period to early lactation the cow goes through a dramatic change in her metabolism. To supply the high energy requirement in early lactation fat supply from the diet and body mobilisation increases substantially. As a result, the liver accumulates fat, the rate of detoxification slows down, ammonia accumulates and there’s a reduced supply of fat, glucose and protein to the udder. This trial was designed to evaluate the response of dairy cows to product called ABN-LiFT a proprietary mixture of B-group vitamins and methyl group donors (rumen protected choline, niacin, vitamin B12

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12

Yuan, K., R. D. Shaver, S. J. Bertics, M. Espineira, and R. R. Grummer. "Effect of rumen-protected niacin on lipid metabolism, oxidative stress, and performance of transition dairy cows." Journal of Dairy Science 95, no. 5 (2012): 2673–79. http://dx.doi.org/10.3168/jds.2011-5096.

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13

Rungruang, S., J. L. Collier, R. P. Rhoads, L. H. Baumgard, M. J. de Veth, and R. J. Collier. "A dose-response evaluation of rumen-protected niacin in thermoneutral or heat-stressed lactating Holstein cows." Journal of Dairy Science 97, no. 8 (2014): 5023–34. http://dx.doi.org/10.3168/jds.2013-6970.

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14

Yuan, K., R. D. Shaver, M. Espineira, and S. J. Bertics. "Effect of a rumen-protected niacin product on lactation performance by dairy cows during summer in Wisconsin." Professional Animal Scientist 27, no. 3 (2011): 190–94. http://dx.doi.org/10.15232/s1080-7446(15)30473-3.

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15

Pineda, A., J. K. Drackley, J. Garrett, and F. C. Cardoso. "Effects of rumen-protected niacin on milk production and body temperature of middle and late lactation Holstein cows." Livestock Science 187 (May 2016): 16–23. http://dx.doi.org/10.1016/j.livsci.2016.02.004.

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16

Holzmann, Vitória Maria Montenegro, Milena Trentin, Fabíola Cristine de Almeida Rego, Luiz Fernando Coelho Cunha Filho, and Agostinho Ludovico. "Melatonin concentration in the milk of cows supplemented with vitamins and milked twice daily." Semina: Ciências Agrárias 40, no. 5 (2019): 2017. http://dx.doi.org/10.5433/1679-0359.2019v40n5p2017.

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Melatonin, a hormone secreted in cow milk, has beneficial effects on human health. This study aimed to evaluate the effects of dietary vitamin supplementation and nocturnal milking on the concentration of melatonin in cow milk. Twenty-one confined cows in the final period of lactation were used for the study and the supplemented vitamins were: rumen-protected B vitamins, A, D3, E, and niacin (B3) not protected from rumen degradation. The experimental period had a duration of 10 days. Milk samples were collected during the first two days, without supplementation of vitamins (WITHOUT), and durin

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17

Eweedah, N. M., A. Y. Salem, H. M. Gaafar, et al. "Effect of rumen protected niacin and vitamin C additives on productive performance of lactating Friesian cows under heat stress condition." Indian Journal of Veterinary Research (The) 30, no. 1 (2021): 7–18. http://dx.doi.org/10.5958/0974-0171.2021.00001.7.

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18

Zeitz, J. O., A. Weber, E. Most, et al. "Effects of supplementing rumen-protected niacin on fiber composition and metabolism of skeletal muscle in dairy cows during early lactation." Journal of Dairy Science 101, no. 9 (2018): 8004–20. http://dx.doi.org/10.3168/jds.2018-14490.

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19

Ringseis, R., J. O. Zeitz, A. Weber, C. Koch, and K. Eder. "Hepatic transcript profiling in early-lactation dairy cows fed rumen-protected niacin during the transition from late pregnancy to lactation." Journal of Dairy Science 102, no. 1 (2019): 365–76. http://dx.doi.org/10.3168/jds.2018-15232.

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20

Richards, S. E., S. Hicklin, T. Lord, et al. "Effects of B vitamins and methyl group donors on milk production, milk composition and blood biochemistry in dairy cows." Proceedings of the British Society of Animal Science 2002 (2002): 196. http://dx.doi.org/10.1017/s1752756200008528.

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Recent reviews highlight the importance of the liver in the coordination of nutrient fluxes in support of pregnancy and lactation (e.g. Drackley et al., 2001). Mobilisation of body fat reserves in the late dry period and early lactation leads to an increase in uptake of non-esterified fatty acids (NEFA) by the liver. Their metabolic fate is either oxidation or esterification into triacylglycerides (TAG) that are either exported in very low density lipoproteins (VLDL) or accumulated within liver cells. Recent evidence indicates that TAG accumulation impairs ureagenic and gluconeogenic capacity

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21

kortam, laila Esmael, noha elsayed aref, Mohamed Samy Elgarhi, and MAHA Abdelhamed IBRAHIM. "Study on the effects of rumen-protected niacin (RPN) on immunity, production and reproduction performance in dairy cows during summer season." Assiut Veterinary Medical Journal 70, no. 183 (2024): 0. http://dx.doi.org/10.21608/avmj.2024.285953.1248.

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22

Gaowa, Naren, Erdan Wang, Shengli Li, et al. "PSXIII-32 Effects of rumen-protected niacin on dry mater intake, rumination, and milk production in multiparous Holstein dairy cow during transition period." Journal of Animal Science 97, Supplement_3 (2019): 365–66. http://dx.doi.org/10.1093/jas/skz258.729.

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Abstract The dairy cows decrease dry mater intake (DMI) before calving and are frequently in negative energy balance after calving. The objective of this study was to investigate the effect of rumen-protected niacin (NA) on DMI, rumination, and milk production in multiparous Holstein dairy cows during transition period. Eighteen multiparous Holstein dairy cows were allocated into 3 groups: (1) control diet (Con; n = 6), not supplemented with NA, (2) supplemented diet 1 (NA1; supplemented with 20 g NA/cow daily, n = 6), and (3) supplemented diet 2 (NA2; supplemented with 40 g NA/cow daily, n =

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23

Gaowa, Naren, Xiaoming Zhang, Huanxu Li, et al. "Effects of Rumen-Protected Niacin on Dry Matter Intake, Milk Production, Apparent Total Tract Digestibility, and Faecal Bacterial Community in Multiparous Holstein Dairy Cow during the Postpartum Period." Animals 11, no. 3 (2021): 617. http://dx.doi.org/10.3390/ani11030617.

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Extensive studies about rumen-protected niacin (RPN) supplementation on dairy cows in early-lactation have been done, but the effects of RPN on changes in dry matter intake (DMI), milk production, feed digestibility, and fecal bacterial community were conflicting. The aim of this study was to investigate them affected by RPN in postpartum cows. Multiparous Holstein dairy cows (n = 12, parity = 3.5 ± 0.5, body weights = 740 ± 28 kg) were divided into two groups supplemented with either 0 (CON) or 20 g/d RPN (RPN). Our results showed that RPN supplementation increased DMI and milk production of

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24

Zimbelman, R. B., R. J. Collier, and T. R. Bilby. "Effects of utilizing rumen protected niacin on core body temperature as well as milk production and composition in lactating dairy cows during heat stress." Animal Feed Science and Technology 180, no. 1-4 (2013): 26–33. http://dx.doi.org/10.1016/j.anifeedsci.2013.01.005.

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25

Guo, W. J., L. Zhen, J. X. Zhang, et al. "Effect of feeding Rumen-protected capsule containing niacin, K 2 SO 4 , vitamin C, and gamma-aminobutyric acid on heat stress and performance of dairy cows." Journal of Thermal Biology 69 (October 2017): 249–53. http://dx.doi.org/10.1016/j.jtherbio.2017.06.011.

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26

Chen, Yong, Guang Wang, Xingbo Yu, Li Zhen, and Yongli Qu. "Impact of Rumen-Protected Niacin on Milk Production Performance and Blood Biochemical Indexes of Dairy Cows Under Mild Heat Stress." Indian Journal of Animal Research, of (October 22, 2019). http://dx.doi.org/10.18805/ijar.b-1109.

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To study the influence of rumen-protected niacin on mild heat-stressed dairy cow, 30 healthy high-yielding dairy cows with similar parity were selected and randomly divided into three groups and were fed the rations with 0g/d, 6g/d and 12g/d rumen-protected niacin respectively. The results showed that the dairy cows were in mild heat stress during the experiment and the time of test day significantly affected the milk yield, FCM and respiration rate of cows. Rumen-protected niacin supplement neither altered the dairy cow’s body temperature, skin temperature and respiration rate, nor affected t

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27

Gaston, F. Alfaro, L. Rodriguez-Zas Sandra, Southey Bruce, et al. "Complete blood count analysis on beef cattle exposed to fescue toxicity and rumen-protected niacin supplementation." February 2, 2021. https://doi.org/10.5281/zenodo.4564620.

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Fescue toxicity is the result of cattle consuming fungal (Ergot spp.) endophyte-infected tall fescue. Ergot alkaloids produce vasoconstriction in cattle. Our objectives were to analyze changes in complete blood count due to ergot alkaloid detoxification in growing offspring. Furthermore, to assess the effects of offspring performance consuming endophyte-infected tall fescue or endophyte-free tall fescue seeds in addition to rumen-protected niacin, and to assess the efficacy of niacin in a non-toxic diet for beef cattle. Typical signs of intoxication with alkaloids and heat stress were noticed

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28

Krogstad, K. C., R. J. Vlietstra, J. R. Pursley, E. Grilli, and B. J. Bradford. "On-farm supplementation of rumen-protected niacin: a randomized clinical trial." Journal of Dairy Science, December 2024. https://doi.org/10.3168/jds.2024-25489.

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29

Krogstad, K. C., J. F. Fehn, L. K. Mamedova, M. P. Bernard, and B. J. Bradford. "Effects of rumen-protected niacin on inflammatory response to repeated intramammary lipopolysaccharide challenges." Journal of Dairy Science, June 2024. http://dx.doi.org/10.3168/jds.2024-24974.

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30

"Correction: Hepatic transcript profiling in beef cattle: Effects of rumen-protected niacin supplementation." PLOS ONE 20, no. 1 (2025): e0317922. https://doi.org/10.1371/journal.pone.0317922.

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31

GF, Alfaro, Muntifering RB, Pacheco WJ, Rodning SP, and Moisá SJ. "Effects of endophyte-infected tall fescue on performance of genotyped pregnant beef cows supplemented with rumen-protected niacin." Livestock Science, March 2023, 105206. http://dx.doi.org/10.1016/j.livsci.2023.105206.

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32

Eweedah, Nabil. "Effect of Rumen-Protected Niacin and Vitamin C Supplements on Productive Performance of Lactating Friesian Cows under Heat Stress Condition." Pakistan Journal of Zoology, 2023. http://dx.doi.org/10.17582/journal.pjz/20220809010838.

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