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Journal articles on the topic 'Ruzu bitters'

Author: Grafiati

Published: 4 June 2025

Last updated: 15 July 2025

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1

Monsi, Tombari Pius, Melford Miller Chinwebudu, and Samuel Douglas Abbey. "Bioinformatics of blaTEM-1 and blaSHV Genes of Herbal Drugs Pretreated-Klebsiella pneumoniae." International Journal of Pathogen Research 14, no. 2 (2025): 43–57. https://doi.org/10.9734/ijpr/2025/v14i2349.

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Background: Oral intake of herbal medicinal products may ultimately lead to their interaction with the intestinal microbial community in which Klebsiella pneumoniae is a resident. Aim: This study investigated the effect of some herbal medicinal products consumed on beta-lactamase genes, specifically blaSHV and blaTEM, present in a key gut pathogen, K. pneumoniae. Methods: The study adopted an experimental approach with two strains of K. pneumoniae. Both strains were treated in four herbal medicinal products (Goko bitters, Goko alcoholic bitter, Ruzu bitters and Beta cleanser). The resistant ge

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2

Ebuehi, Osaretin Albert T., Lasekan Oyindamola Ayobami, and Olufemi Mulkah Ajagun-Ogunleye. "Biochemical Impact of Carica Papaya (Pawpaw) leaves Extract and Ruzu Bitters on Hematology and Brain Histology in Sprague Dawley Rats." Recent Progress in Nutrition 03, no. 01 (2023): 1–26. http://dx.doi.org/10.21926/rpn.2301004.

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Plant-based products have been utilized for nutritional and medicinal purposes for decades. Although the reported benefits of <em>Carica papaya </em>(Pawpaw) leave extract, its role in hematology, brain histology, and the possible side effect are still areas of research deliberation. Thirty (30) male Sprague Dawley rats, divided into three groups, were fed on rat chow and normal saline, <em>Carica papaya </em>leaves extract and Ruzu bitters, respectively. Blood chemistry, hematology, and brain histology were assayed to ascertain their effects on brain structure and bioc

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3

Emaleku, S. A., I. G. Adanlawo, I. O. Omotuyi, et al. "Anti-Diabetic potentials of Ruzu herbal bitters in Type 1 Diabetes Mellitus-induced Albino rats." Ife Journal of Science 21, no. 2 (2019): 401. http://dx.doi.org/10.4314/ijs.v21i2.13.

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4

Obasi, David C., and Victor N. Ogugua. "GC-MS analysis, pH and antioxidant effect of Ruzu herbal bitters on alloxan-induced diabetic rats." Biochemistry and Biophysics Reports 27 (September 2021): 101057. http://dx.doi.org/10.1016/j.bbrep.2021.101057.

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5

Ogunlana, Olubanke O., Oluseyi E. Ogunlana, Tobi S. Adekunbi, Babatunde O. Adetuyi, Bose E. Adegboye, and Franklyn N. Iheagwam. "Anti-inflammatory Mechanism of Ruzu Bitters on Diet-Induced Nonalcoholic Fatty Liver Disease in Male Wistar Rats." Evidence-Based Complementary and Alternative Medicine 2020 (July 23, 2020): 1–8. http://dx.doi.org/10.1155/2020/5246725.

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Nonalcoholic fatty liver disease (NAFLD) has become notorious globally. Increasingly emerging evidence shows that NAFLD is strongly associated with inflammation, with proinflammatory cytokines such as interleukin-2 (IL-2), interleukin-6 (IL-6), and tumour necrosis factor-α (TNF-α) playing a vital role in its progression. In this work, an attempt was made to verify the anti-inflammatory activity of Ruzu herbal bitters (RHB), an antiobesity medicinal concoction, on NAFLD induced by a high-fat diet (HFD) in albino Wistar rats. Twenty-five (25) rats were divided into five groups as follows: Group

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6

Ogunlana, Olubanke O., Babatunde O. Adetuyi, Tobi S. Adekunbi, Bose E. Adegboye, Franklyn N. Iheagwam, and Oluseyi E. Ogunlana. "Ameliorative effect of Ruzu herbal bitters on high-fat diet induced non-alcoholic fatty liver disease in Wistar rats." Journal of Pharmacy & Pharmacognosy Research 9, no. 3 (2021): 251–60. http://dx.doi.org/10.56499/jppres20.868_9.3.251.

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Context: One of the world’s most widespread and frequent liver diseases is the non-alcoholic fatty liver disease (NAFLD). Aims: To evaluate the preventives activities of Ruzu herbal bitters (RHB), which is an anti-obesity therapeutic concoction used widely in Nigeria on high–fat diet (HFD) induced NAFLD in albino Wistar rats. Methods: A total number of twenty-five rats were isolated and divided equally into five groups. Group 1, the normal control group was placed on normal rat diet and normal saline (1 mL/kg body weight daily) for twelve weeks. The remaining four groups 2-5 were placed on HFD

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7

Oyadeyi, Ayodele, Folasade Ajao, Temitope Babalola, and Yusuf Mustapha. "Effects of Ruzu, a Polyherbal Mixture, on Neurobehaviour and Expression of Serotonin and Dopamine Transporters in Rats." Nigerian Journal of Physiological Sciences 36, no. 2 (2021): 173–80. http://dx.doi.org/10.54548/nigerjphysiolsci.v36i2.5.

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There is increased possibility that combined herbal constituents may interact to increase toxicity and lower efficacy. Ruzu herbal bitters (RHB) is a blend of extracts from Curculigo pilosa, Uvaria chamae, and Citrullus colocynthis, each of which has been shown to possess important bio-effects. There is anecdotal evidence for efficacy of RHB in neurological disorders; however, there are no data on possible neurotoxic effects of RHB. Using behavioural, biochemical and molecular indices as surrogates of neurotoxicity, this study therefore evaluated the nervous system effects of RHB. Twenty male

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8

Oyadeyi, Ayodele, Folasade Ajao, Temitope Babalola, and Yusuf Mustapha. "Effects of Ruzu, a Polyherbal Mixture, on Neurobehaviour and Expression of Serotonin and Dopamine Transporters in Rats." Nigerian Journal of Physiological Sciences 36, no. 2 (2021): 173–80. http://dx.doi.org/10.54548/njps.v36i2.5.

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There is increased possibility that combined herbal constituents may interact to increase toxicity and lower efficacy. Ruzu herbal bitters (RHB) is a blend of extracts from Curculigo pilosa, Uvaria chamae, and Citrullus colocynthis, each of which has been shown to possess important bio-effects. There is anecdotal evidence for efficacy of RHB in neurological disorders; however, there are no data on possible neurotoxic effects of RHB. Using behavioural, biochemical and molecular indices as surrogates of neurotoxicity, this study therefore evaluated the nervous system effects of RHB. Twenty male

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9

Oluwaseyi, Adegoke Adetunji, Christiana Adetunji Oluwafunmilola, Aimalohi Agbebaku-Izobo Grace, et al. "Toxicological evaluation of a Nigeria-made polyherbal product on selected reproductive functions in adult male Wistar rats." World Journal of Advanced Research and Reviews 11, no. 3 (2021): 001–8. https://doi.org/10.5281/zenodo.5558700.

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Ruzu bitters black for men (RBBM) is a polyherbal product widely used amongst men in Nigeria to enhance libido, rejuvenate male organs and to manage erectile dysfunctions, prostate anomalies, weak erection, and premature ejaculation. This study was carried out to investigate the toxicological effect from the use of herbal product. Acute toxicity test of RBBM on rats was carried out in two phases; 10 mg/kg, 100 mg/kg and 1000 mg/kg for phase I and 1600mg/kg, 2900 mg/kg and 5000 mg/kg for phase II, were administered respectively. For sub-acute toxicity, two groups of 5 animals each received RBBM

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10

Oluwaseyi Adegoke Adetunji, Oluwafunmilola Christiana Adetunji, Grace Aimalohi Agbebaku-Izobo, et al. "Toxicological evaluation of a Nigeria-made polyherbal product on selected reproductive functions in adult male Wistar rats." World Journal of Advanced Research and Reviews 11, no. 3 (2021): 001–8. http://dx.doi.org/10.30574/wjarr.2021.11.3.0410.

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Ruzu bitters black for men (RBBM) is a polyherbal product widely used amongst men in Nigeria to enhance libido, rejuvenate male organs and to manage erectile dysfunctions, prostate anomalies, weak erection, and premature ejaculation. This study was carried out to investigate the toxicological effect from the use of herbal product. Acute toxicity test of RBBM on rats was carried out in two phases; 10 mg/kg, 100 mg/kg and 1000 mg/kg for phase I and 1600mg/kg, 2900 mg/kg and 5000 mg/kg for phase II, were administered respectively. For sub-acute toxicity, two groups of 5 animals each received RBBM

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11

Ogunlana, Olubanke Olujoke, Oluseyi Ebenezer Ogunlana, Stanley Kelechukwu Ugochukwu, and Alaba Oladipupo Adeyemi. "Assessment of the Ameliorative Effect of Ruzu Herbal Bitters on the Biochemical and Antioxidant Abnormalities Induced by High Fat Diet in Wistar Rats." International Journal of Pharmacology 14, no. 3 (2018): 329–41. http://dx.doi.org/10.3923/ijp.2018.329.341.

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12

Aja, P. M., E. U. Ekpono, N. A. Obasi, D. C. Obasi, and J. Nwaeke. "Comparative Amino Acid Compositions of Uvaria chamae Stem Bark and Poly Herbal Mixture." Earthline Journal of Chemical Sciences, May 29, 2019, 79–95. http://dx.doi.org/10.34198/ejcs.2119.7995.

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The study evaluated comparative amino acids compositions of Uvaria chamae stem bark and Ruzu bitters. The amino acids compositions were determined using amino acid analyzer. The result of amino acid composition showed that eighteen amino acids were detected in both samples. Ten of the detected amino acids were essential amino acids and eight were non-essential. Glumatic acid had the highest concentration of 10.90 and 5.15 g/100g protein in Uvaria chamae stem bark and Ruzu bitters followed by aspartic acid with values of 8.40 and 3.44 g/100 g protein in Uvaria chamae stem bark and Ruzu bitters

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13

Onugwu, S. O., C. O. Ezugwu, U. E. Odoh, and A. L. Onugwu. "Phytochemical, Biochemical and Biological Evaluation of Five Herbal Bitters Sold in Pharmacy Shops in Eastern Nigeria." Journal of Advances in Medical and Pharmaceutical Sciences, November 25, 2021, 1–11. http://dx.doi.org/10.9734/jamps/2021/v23i930255.

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Aim: This study investigated the phytochemical constituents, antimicrobial and antioxidant properties of five herbal bitters and their potential effect on body weight, lipid profile, hematology, liver and kidney functions of albino rats. Methods: Five brands of herbal bitters (Goko Cleanser®, Ruzu Bitter®, Yoyo Bitter®, Swedish Bitter® and Beta Cleanser®) were tested for the presence of phytochemical constituents. Antimicrobial activity was evaluatedby agar diffusion method. The weights of the animals were taken before treatment, and on day 7, 14, 21 and 28 post treatments with the herba

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14

"Effects of Ruzu Herbal Bitters, a Traditional Nigerian Polyherbal Drug, on Longevity and Selected Toxicological Indices in Drosophila melanogaster." Biointerface Research in Applied Chemistry 11, no. 2 (2020): 9638–45. http://dx.doi.org/10.33263/briac112.96389645.

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There is a steady rise in human consumption of herbal mixtures, particularly in developing countries. This has led to the constant demand for safety evaluation of herbal mixtures by regulatory bodies. Here, the fruit fly, Drosophila melanogaster was used for the safety evaluation of Ruzu Herbal Bitters, a polyherbal mixture. Firstly, 14 days of survival followed by longevity studies were carried out on flies treated with Ruzu (0, 20, 40, and 60 µL/g diet). Then a similar treatment was carried out for 5 days to assess selected biochemical markers. The results showed no significant effect was no

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15

Briggs, Ojoye N., Kemzi N. Elechi-amadi, Tarila N. Aleruchi-Didia, Eberechukwu O. Anyalebechi, and Shammah Agwor. "Effects of the Anti-diabetic Polyherbal (Ruzu Bitters) on Glucose, Hepatic and Renal Parameters in Alloxan-induced Diabetic Rats." Journal of Advances in Medical and Pharmaceutical Sciences, June 21, 2022, 44–51. http://dx.doi.org/10.9734/jamps/2022/v24i430296.

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Aim: This study evaluated the effects of the anti-diabetic polyherbal (Ruzu Bitters) on glucose, hepatic and renal parameters in alloxan-induced diabetic rats. Methodology: A total of 35 male Albino rats weighing between 120-140 g were used for this study. Diabetes was induced by a single intraperitoneal injection of freshly prepared alloxan-monohydrate (140 mg/kg body weight). Fasting plasma glucose (FPG) was determined using the glucose oxidase method. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined using Reitman-Frankel method, while alkaline phosph

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16

Obasi, David C., and Victor N. Ogugua. "Effect of Ruzu Herbal Bitters on the Liver Function and Lipid Profile Parameters of Alloxan-Induced Diabetic Rats." Journal of Clinical and Experimental Hepatology, September 2021. http://dx.doi.org/10.1016/j.jceh.2021.09.012.

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17

"Hepatic and Nephro-Modulatory Activity of Oral and Repeated Exposure to Ruzu Bitters (a Nigerian Polyherbal Formulation) in Wistar Rats." Letters in Applied NanoBioScience 13, no. 2 (2024): 66. https://doi.org/10.33263/lianbs132.066.

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This study aimed to evaluate the toxic effect of Ruzu Herbal Bitters (RHB). Thirty male Wistar rats were allocated into five groups of 6 animals each. In the space of 28 days, distilled water and RHB were administered orally at concentrations of 0.04, 0.08, 0.13, and 0.20 mL/kg body weight, respectively. After this treatment, the animals were sacrificed, and the plasma, liver, and kidney obtained were used for the determination of Protein concentration, Creatinine, Urea, Bilirubin, Alkaline Phosphatase (ALP), Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) and Lactate Dehydrog

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