Academic literature on the topic 'Rwandese women'

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Journal articles on the topic "Rwandese women"

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Petry, Nicolai, Ines Egli, Jean B. Gahutu, Pierrot L. Tugirimana, Erick Boy, and Richard Hurrell. "Phytic Acid Concentration Influences Iron Bioavailability from Biofortified Beans in Rwandese Women with Low Iron Status." Journal of Nutrition 144, no. 11 (September 3, 2014): 1681–87. http://dx.doi.org/10.3945/jn.114.192989.

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Masaisa, Florence, Candace Breman, Jean Bosco Gahutu, Joshua Mukiibi, Joris Delanghe, and Jan Philippé. "Ferroportin (SLC40A1) Q248H mutation is associated with lower circulating serum hepcidin levels in Rwandese HIV-positive women." Annals of Hematology 91, no. 6 (January 17, 2012): 911–16. http://dx.doi.org/10.1007/s00277-011-1400-3.

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Petry, Nicolai, Ines Egli, Jean B. Gahutu, Pierrot L. Tugirimana, Erick Boy, and Richard Hurrell. "Stable Iron Isotope Studies in Rwandese Women Indicate That the Common Bean Has Limited Potential as a Vehicle for Iron Biofortification." Journal of Nutrition 142, no. 3 (February 1, 2012): 492–97. http://dx.doi.org/10.3945/jn.111.149286.

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Petry, Nicolai, Fabian Rohner, Jean Bosco Gahutu, Bruno Campion, Erick Boy, Pierrot L. Tugirimana, Michael Bruce Zimmerman, Christian Zwahlen, James P. Wirth, and Diego Moretti. "In Rwandese Women with Low Iron Status, Iron Absorption from Low-Phytic Acid Beans and Biofortified Beans Is Comparable, but Low-Phytic Acid Beans Cause Adverse Gastrointestinal Symptoms." Journal of Nutrition 146, no. 5 (March 30, 2016): 970–75. http://dx.doi.org/10.3945/jn.115.223693.

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Nekhai, Sergei, Namita Kumari, Min Xu, Altreisha Foster, Sharmin Diaz, and Victor R. Gordeuk. "Ferroportin Q248H Mutation Protects From HIV-1 Infection in Vitro." Blood 120, no. 21 (November 16, 2012): 993. http://dx.doi.org/10.1182/blood.v120.21.993.993.

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Abstract Abstract 993 Ferroportin is the only iron exporter expressed in mammalian cells, and hepcidin produced by the liver binds to ferroportin leading to its internalization and degradation by lysosomes. We recently reported that expression of ferroportin in 293T cells transfected with HIV-1 LTR-LacZ and Tat expression vector led to decreased HIV transcription, possibly by reducing availability of intracellular iron, and that exposure to hepcidin restored HIV transcription1. The Q248H mutation in ferroportin has an allele frequency of 2.2–13.4% in African populations and is associated with a mild tendency to increased serum ferritin in the general population. The ferroportin Q248H mutation was reported to associate with lower hepcidin levels in HIV-1 infected Rwandese women2. We also recently showed that ferroportin Q248H mutant has reduced sensitivity to physiologic hepcidin concentrations. We expressed WT and Q248H mutant ferroportin in 293T cells that express very low levels of endogenous ferroportin. We also expressed ferroportin C326Y, a mutant that is not sensitive to hepcidin. We analyzed the effect of ferroportin Q248H on cellular Intracellular ferritin levels which reflect the amount of iron stored within the cells. 293T cells were transfected with ferroportin expressing vectors, incubated with ferric ammonium citrate as a source of iron, pretreated with cycloheximide to stop de-novo protein synthesis and then treated with 30 nM hepcidin. Ferritin levels increased significantly in the cells expressing WT ferroportin and treated with hepcidin (Fig.1A). In contrast, ferritin levels remained the same in untreated and hepcidin treated cells expressing ferroportin Q248H or C326Y (Fig.1A). This observation suggests continuing iron export by ferroportin Q248H with low dose hepcidin. HIV-1 transcription can be induced in 293T cells by co-expression of HIV-1 LTR reporter construct and HIV-1 Tat expression vector (Fig.1B, lane 2). HIV-1 Tat binds to TAR RNA located in the beginning of HIV-1 transcript and facilitates a recruitment of a host cell transcription elongation factor, CDK9/cyclin T1, inducing efficient elongation of HIV-1 transcription. Expression of ferroportin WT, Q248H or C326Y mutant inhibited Tat –induced HIV-1 transcription in comparison to non-relevant control (Fig.1B, lanes 3, 4, 6 and 8). Treatment with physiological hepcidin concentrations reversed the inhibition of Tat-induced HIV-1 transcription by WT but not the Q248H or C326Y mutant ferroportin (Fig.1B, lanes 5, 7 and 9). In this experiment, we utilized c-myc tagged ferroportin expression vectors as in our previous study1. We also obtained very similar results with EGFP-fused ferroportin expression, which also allowed an easier detection of reduction in ferroportin expression in the presence of hepcidin. Finally, we also isolated monocytes from two subjects, one with heterozygote and one with homozygote ferroportin Q248H. Monocytes were infected ex-vivo with pseudotyped HIV-1 virus expressing luciferase. HIV-1 replication was reduced in primary monocytes with heterozygote and homozygote ferroportin Q248H as compared to a control. Ferroportin glutamine 248 is located within the intracellular loop (residues 228–307), in close proximity to lysine residues 229–269 which ubiquitination promotes ferroportin internalization3. Future studies should address the details of ubiquitination of human ferroportin Q248H compared to WT ferroportin. An added protection value could be observed lower hepcidin expression levels in HIV-1 infected individuals with the ferroportin Q248H2. Further studies are needed to uncover a mechanism of this reduced hepcidin expression. Further molecular analysis is needed to understand the mechanism of ferroportin Q248H internalization. Taken together, our study shows that the ferroportin Q248H that has a reduced sensitivity to hepcidin may offer an additional protection from HIV-1. Acknowledgments. This work was supported NIH Research Grants SC1GM082325, R25 HL003679, 2G12RR003048, 8G12MD007597, K25GM097501 and 1P30HL107253. Disclosures: No relevant conflicts of interest to declare.
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Lohy Das, Jesmin, Stephen Rulisa, Peter J. de Vries, Petra F. Mens, Nadine Kaligirwa, Steven Agaba, Joel Tarning, Mats O. Karlsson, and Thomas P. C. Dorlo. "Population Pharmacokinetics of Artemether, Dihydroartemisinin, and Lumefantrine in Rwandese Pregnant Women Treated for UncomplicatedPlasmodium falciparumMalaria." Antimicrobial Agents and Chemotherapy 62, no. 10 (July 30, 2018). http://dx.doi.org/10.1128/aac.00518-18.

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ABSTRACTThe artemisinin-based combination therapy artemether-lumefantrine is commonly used in pregnant malaria patients. However, the effect of pregnancy-related changes on exposure is unclear, and pregnancy has been associated with decreased efficacy in previous studies. This study aimed to characterize the population pharmacokinetics of artemether, its active metabolite dihydroartemisinin, and lumefantrine in 22 Rwandese pregnant women in their second (n= 11) or third (n= 11) trimester with uncomplicatedPlasmodium falciparummalaria. These patients were enrolled from Rwamagana district hospital and received the standard fixed oral dose combination of 80 mg of artemether and 480 mg of lumefantrine twice daily for 3 days. Venous plasma concentrations were quantified for all three analytes using liquid chromatography coupled with tandem mass spectroscopy, and data were analyzed using nonlinear mixed-effects modeling. Lumefantrine pharmacokinetics was described by a flexible but highly variable absorption, with a mean absorption time of 4.04 h, followed by a biphasic disposition model. The median area under the concentration-time curve from 0 h to infinity (AUC0–∞) for lumefantrine was 641 h · mg/liter. Model-based simulations indicated that 11.7% of the study population did not attain the target day 7 plasma concentration (280 ng/ml), a threshold associated with increased risk of recrudescence. The pharmacokinetics of artemether was time dependent, and the autoinduction of its clearance was described using an enzyme turnover model. The turnover half-life was predicted to be 30.4 h. The typical oral clearance, which started at 467 liters/h, increased 1.43-fold at the end of treatment. Simulations suggested that lumefantrine pharmacokinetic target attainment appeared to be reassuring in Rwandese pregnant women, particularly compared to target attainment in Southeast Asia. Larger cohorts will be required to confirm this finding.
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7

Luna, Sarah, Mercy Lung'aho, Jean Bosco Gahutu, and Jere Haas. "Consuming Iron‐Biofortified Beans Reduces Time Spent in Discretionary Sedentary Activity in Iron‐Depleted Rwandese Women Compared to Conventional Beans." FASEB Journal 29, S1 (April 2015). http://dx.doi.org/10.1096/fasebj.29.1_supplement.605.1.

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8

"Erratum for Petry et al. Phytic acid concentration influences iron bioavailability from biofortified beans in Rwandese women with low iron status. J Nutr 2014;144:1681–7." Journal of Nutrition 145, no. 8 (August 1, 2015): 1973. http://dx.doi.org/10.3945/jn.115.214254.

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Dissertations / Theses on the topic "Rwandese women"

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Banyanga, Jean D'Amour. "Biblical counselling for spiritually wounded women who suffered the 1994 genocide : a case study of Rwandese women between ages 35-55, living in Kibuye / Jean D'Amour Banyanga." Thesis, North-West University, 2008. http://hdl.handle.net/10394/2881.

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This study was prompted by the remarkable need for pastoral counselling for wounded Rwandese women. Many women that survived the 1994 genocide in Rwanda had been widowed, raped and beaten, had cut their arms and legs, had been forced to kill their own children and were infected with HIV/AIDS during that time. They were emotionally, spiritually and physically wounded by the 1994 genocide. They do not have hope for tomorrow; they do not have peace in their minds because of what happened to them and to their beloved ones. In addition, some Christians left the church, saying that God is no longer there because more Rwandese died in the church than anywhere else, while thinking that it would be a safe place. The main question that this study aims to address, is: What pastoral guidelines can be given to wounded Rwandese women between the ages of 35-55 in Kibuye who suffered from the 1994 genocide? In addressing this question, the study attempts to answer the following questions: • What pastoral guidelines does the Bible provide with regard to counselling wounded people in a situation of genocide? • What do secular literature indicate with regard to counselling in a case of genocide? • What impact did the genocide have on the Rwandese women between ages of 35-55 in Kibuye? • What pastoral guidelines may be given to the wounded person? The aim of this study is therefore to find and formulate pastoral guidelines that can be used in counselling the Rwandese women aged 35-55 in Kibuye who suffered from the 1994 genocide. The study utilises Zerfass' model (1974:164-177) for Practical Theology. This method comprises the basic theory, the meta-theory and the praxis theory. Finally, the researcher utilises the Bible to formulate and propose some Biblical guidelines that would help wounded Rwandese women to cope with their wounds so that they may live a holy life even though their situation is bad.
Thesis (M.A. (Pastoral))--North-West University, Potchefstroom Campus, 2009.
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Books on the topic "Rwandese women"

1

Hamwe, Pro-Femmes/Twese. Situation de la femme rwandaise. Kigali: Pro-Femmes/Twese Hamwe, 1994.

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Hategekimana, Grégoire. Recueil des études et ouvrages ayant trait à la femme rwandaise. Kigali: Fonds des Nations Unies pour l'enfance, 1992.

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Mugwaneza, Annie. Recueil des études et ouvrages ayant trait à la femme Rwandaise: Bibliographie analytique. Kigali: Réseau des femmes oeuvrant pour le développement rural, 1989.

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Ntampaka, Charles. Ce que la femme et la fille rwandaise doivent savoir de leurs droits. Kigali: Haguruka, Association pour la défense des droits de la femme et de l'enfant, 1993.

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Atelier, sur l'approche genre et le statut juridique de la femme rwandaise (1999 Kigali Rwanda). Atelier sur l'approche genre et le statut juridique de la femme rwandaise: Rapport définitif. Kigali: Le Ministr̀e, 1999.

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Proceedings of a workshop on "inclusion of Rwandese women's concerns in national land policy and law formulation process in Rwanda": Novotel Umubano Hotel, 19-20 July 2001. Kigali: The Ministry, 2001.

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Germaine, Bucyedusenge, ed. Le Role de la femme dans l'agriculture rwandaise. Kigali: République rwandaise, Ministère de l'agriculture, de l'élevage et des forêts, 1990.

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Association pour la défense des droits de la femme et de l'enfant., ed. La femme rwandaise et l'accès à la justice. [Kigali]: HAGURUKA, 2001.

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Réseau des femmes oeuvrant pour le développement rural. and Service d'appui à la Coopération canadienne (Rwanda), eds. Profil socio-économique de la femme rwandaise: Version finale, 1991. Kigali: Réseau des femmes oeuvrant pour le développement rural, 1991.

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Rwanda. Ministère de genre et de la promotion de la femme., ed. Plan d'actions pour la promotion du statut juridique de la femme rwandaise: Document provisoire. [Kigali?]: République rwandaise, Ministère du genre et de la promotion de la femme, 1999.

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