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Journal articles on the topic 'S-methyl derivatives'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Kaválek, Jaromír, Josef Jirman, and Vojeslav Štěrba. "Kinetics and mechanism of rearrangement and methanolysis of acylphenylthioureas." Collection of Czechoslovak Chemical Communications 50, no. 3 (1985): 766–78. http://dx.doi.org/10.1135/cccc19850766.

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S-Acyl-1-phenylthioureas and their 3-methyl derivatives are rearranged to 1-acyl derivatives of thiourea in methanolic solution. The rearrangement of the 1-acyl-1-phenyl derivative to the thermodynamically more stable 3-acyl derivative is subject to specific base catalysis. The rearrangement of acetyl group is about 2 orders of magnitude slower than that of benzoyl group. 1-Acetyl-l-phenylthiourea undergoes base-catalyzed methanolysis (giving phenylthiourea and methyl acetate) instead of the rearrangement. The methanolysis rates of l-acyl-3-phenylthioureas and their N-methyl derivatives have b

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2

Khalifa, Nagy M., Ahmed M. Naglah, Mohamed A. Al-Omara, and Abd El-Galil E. Amr. "Synthesis and Reactions of New Chiral Linear Dipeptide Candidates Using Nalidixic Acid as Starting Material." Zeitschrift für Naturforschung B 69, no. 6 (2014): 728–36. http://dx.doi.org/10.5560/znb.2014-4031.

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A series of dipeptide heterocyclic derivatives 4-15 were synthesized using methyl 2-{[(1-ethyl- 7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridin-3-yl)carbonyl]amino}-3-ethylbutanoate (3) as starting material. Treatment of 3 with L-phenylalanine methyl ester hydrochloride afforded the corresponding dipeptide methyl ester derivative 4, which was treated with hydrazine hydrate to afford the dipeptide acid hydrazide 5. Compound 5 was coupled with aldehyde and acetophenone derivatives to afford the corresponding Schiff bases 6a-f. The hydrazide derivative 5 was reacted with ethyl acetoacetate or acetone

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3

Patroni, JJ, RV Stick, BW Skelton та AH White. "The Selective Monobenzylidenation of Some Monosaccharides and Their Derivatives With α,α-Dimethoxytoluene". Australian Journal of Chemistry 41, № 1 (1988): 91. http://dx.doi.org/10.1071/ch9880091.

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The treatment of some monosaccharides and their derivatives with a,a-dimethoxytoluene and an acid catalyst in dimethylformamide at about 80° can lead to selective benzylidenation , e.g. methyl a-D- mannopyranoside gives mainly methyl 4,6-Obenzylidene-a-D-mannoside, together with two other minor monobenzylidene derivatives (2,3-) and two minor dibenzylidene derivatives (2,3:4,6-). The treatment of various other pyranoses and pyranosides is also described. As well, a 1H n.m.r . study of the acid transformation of some of the above α-D- mannosides is reported, together with a single-crystal X-ray

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4

Janeba, Zlatko, Antonín Holý, and Milena Masojídková. "Transformation of 8-[(2-Hydroxyalkyl)sulfanyl]adenines to 6-Amino-7H-purin-8(9H)-one Derivatives." Collection of Czechoslovak Chemical Communications 66, no. 9 (2001): 1393–406. http://dx.doi.org/10.1135/cccc20011393.

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Alkylation of 6-amino-7H-purin-8(9H)-thione (8-sulfanyladenine, 1) with one equivalent of (R)-[(trityloxy)methyl]oxirane gave its S-alkyl derivative 2, which was converted to the 6-amino-7H-purin-8(9H)-one (3), while alkylation of 1 with two equivalents of (S)-[(trityloxy)methyl]oxirane afforded a mixture of N3,S-dialkylated product 4a, N9-monoalkyl and N7,N9-dialkyl derivatives of 6-amino-7H-purin-8(9H)-one, 5a and 6a, respectively. This approach can be used for rapid and easy transformation of 8-[(2-hydroxyalkyl)sulfanyl]adenines to the derivatives of 6-amino-7H-purin-8(9H)-one (8-hydroxyade

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5

Mahyavanshi, Jyotindra, Snehal Lokhandwala, Jayesh Pandya, and Jigar Patel. "Synthesis, Structural Determination, Docking Study and Bioactivity of Novel Thiophene Derivatives." Asian Journal of Chemistry 36, no. 6 (2024): 1321–26. http://dx.doi.org/10.14233/ajchem.2024.31509.

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The present study reveals 4-methyl-3-(propylamino)thiophene-2-carboxylic acid (Articaine acid) as precursor derivative to synthesize novel thiophene compounds to evaluate their biological activity. The synthesized compounds were subjected to comprehensive characterization techniques including mass spectra, NMR and IR spectroscopy, confirming their structural integrity. Their antimicrobial activity was assessed via minimum inhibitory concentration (MIC) assay against selected bacterial strains. The results emphasize the potential therapeutic applications of these thiophene analogues as efficaci

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6

Lu, Shan, Siegfried Draeger, Barbara Schulz, et al. "Bioactive Aromatic Derivatives from Endophytic Fungus, Cytospora sp." Natural Product Communications 6, no. 5 (2011): 1934578X1100600. http://dx.doi.org/10.1177/1934578x1100600518.

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Two new benzyl γ-butyrolactone analogues, ( R)-5-(( S)-hydroxy(phenyl)-methyl)dihydrofuran-2(3H)-one (1) and its 6-acetate (2), and a new naphthalenone derivative (8), together with eight additional known aromatic derivatives, ( S)-5-(( S)-hydroxy(phenyl)-methyl)dihydrofuran-2(3H)-one (3), ( S)-5-benzyl-dihydrofuran-2(3H)-one (4), 5-phenyl-4-oxopentanoic acid (5), γ-oxo-benzenepentanoic acid methyl ester (6), 3-(2,5-dihydro-4-hydroxy-5-oxo-3-phenyl-2-furyl)propionic acid (7), (3 R)-5-methylmellein (9), integracins A (10) and B (11) were isolated from Cytospora sp., an endophytic fungus isolate

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7

Lee, Yong Hoon, Hee Joo Jang, Kun Hee Park, et al. "Phytochemical Analysis of the Fruits of Sea Buckthorn (Hippophae rhamnoides): Identification of Organic Acid Derivatives." Plants 10, no. 5 (2021): 860. http://dx.doi.org/10.3390/plants10050860.

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Hippophae rhamnoides L. (Elaeagnaceae), commonly known as “Sea buckthorn” and “Vitamin tree”, is a spiny deciduous shrub whose fruit is known for its nutritional composition, such as vitamin C, and is consumed as a dietary supplement worldwide. As part of our ongoing efforts to identify structurally new and bioactive constituents from natural resources, the phytochemical investigation of the extract of H. rhamnoides fruits led to the isolation of one malate derivative (1), five citrate derivatives (2–6), and one quinate derivative (7). The structures of the isolated compounds were elucidated b

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8

Barmaki, Mohammad, Gulgaz Valiyeva, Abel A. Maharramovm, and Mirze M. Allaverdiyev. "Synthesis of 2,3-Dihydro-6-methyl-2-thiopyrimidin-4(1H)-one (6-Methylthiouracil) Derivatives and Their Reactions." Journal of Chemistry 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/176213.

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The synthesis and characterization of 2,3-dihydro-6-methyl-2-thioxopyrimidin-(1H)-one (I) and some of its derivatives has been performed in our lab. Ring-closing cyclization, as a result of the condensation of ethyl-3-oxobutanoate with thiourea in KOH in an ethanol medium produced 2,3-dihydro-6-methy -2-thioxopyrimidin-(1H)-one (I). The reaction of compound (I) with 2- chloroacetic acid in an alkaline KOH solution produced the carboxylate derivative, 2-(2,6-dihydro-4-methyl-6-oxopyrimidin-2-yl-thio)ethanoic acid (II). The reaction of the resulted derivative of carboxylate (II) with the salt of

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9

Glowacz-Czerwonka, Dorota. "Oligoetherols with S-Trazine Ring Based on Hydroxymethyl Derivatives of Methyl Ethyl Ketone." Chemistry & Chemical Technology 11, no. 1 (2017): 45–48. http://dx.doi.org/10.23939/chcht11.01.045.

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10

Lai, Chin-Hung, Chia-Chin Chang, Yi-Lin Weng, and Ta-Hsien Chuang. "Synthesis, Experimental and Density Functional Theory (DFT) Studies on Solubility of Camptothecin Derivatives." Molecules 23, no. 12 (2018): 3170. http://dx.doi.org/10.3390/molecules23123170.

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Two camptothecin derivatives, 10-cyclohexyl-7-methyl-20(S)-camptothecin and 7-methyl-10-morpholino-20(S)-camptothecin, were synthesized and their differences in solubility were investigated using four chosen solvent systems. Based on our results, 10-cyclohexyl-7-methyl-20(S)-camptothecin exhibited higher solubilities than 7-methyl-10-morpholino-20(S)-camptothecin in polar aprotic solvents. However, these two camptothecin derivatives did not exhibit apparent differences in solubility between 5% dimethyl sulfoxide (DMSO)/95% normal saline co-solvent system and 5% dimethylacetamide (DMAC)/95% nor

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11

Krečmerová, Marcela, Antonín Holý, and Milena Masojídková. "Pyrimidine Acyclic Nucleotide Analogues with Aromatic Substituents in C-5 Position." Collection of Czechoslovak Chemical Communications 72, no. 7 (2007): 927–51. http://dx.doi.org/10.1135/cccc20070927.

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NH2-protected 5-phenylcytosine and its derivatives 2a-2d were treated with (2S)-2-[(trityloxy)methyl]oxirane (3) followed by etherification with diisopropyl [(tosyloxy)methyl]phosphonate (5) in the presence of sodium hydride. The intermediary phosphonate esters 6 were debenzoylated and subsequently transformed to free phosphonic acids, i.e. (S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-phenylcytosine (5-phenyl-HPMPC) derivatives (8a-8d) by the action of bromotrimethylsilane and subsequent hydrolysis. Deamination of these compounds with 3-methylbutyl nitrite afforded corresponding (S)-1-[3-hyd

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12

Sihra, Jaspreet K., Alfred E. Thumser, Moses K. Langat, Neil R. Crouch, and Dulcie A. Mulholland. "Constituents of Bulbs of three Species of the Hyacinthaceae (Hyacinthoideae): Eucomis vandermerwei, E. zambesiaca and Resnova humifusa." Natural Product Communications 10, no. 7 (2015): 1934578X1501000. http://dx.doi.org/10.1177/1934578x1501000718.

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Phytochemical analyses of the bulbs of Eucomis vandermerwei and E. zambesiaca yielded homoisoflavonoids and triterpenoid derivatives. A new (17 S*,23 S*)-epoxy-3β,15β,29-trihydroxy-27-norlanost-8-en-24-one) was isolated from E. zambesiaca. Resnova humifusa yielded homoisoflavonoids, and a tetrahydropyran derivative, 2-methyl-3-(4 S*,5 R*,7 S*-trihydroxy-8 S*-hydroxymethyltetrahydro-6H-4-pyranyl)-2-propenoic acid. All compounds were assayed for COX-2 inhibition of cyclooxygenase; 3,5,7-trihydroxy-3-(4′-methoxybenzyl)-4-chromanone was found to have significant activity.

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13

Pert, DJ, and DD Ridley. "An Alternative Route to 2-Bromo-Estradiols and 2-Iodo-Estradiols From Estradiol." Australian Journal of Chemistry 40, no. 2 (1987): 303. http://dx.doi.org/10.1071/ch9870303.

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Through careful choice of reaction conditions, alkylation of estradiol with chloromethyl methyl ether may yield either the 3,17β-bis(methoxymethy1) ether or the 3-methoxymethyl ether derivative. Treatment of either of these protected estradiols with s- butyllithium, then with trimethylsilyl chloride affords, regioselectively, the 2-trimethylsilyl derivatives which can conveniently be converted into 2-bromo-or 2-iodo-estradiol.

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14

Napiórkowska, Mariola, Emilia Grosicka-Maciąg, Piotr Podsadni, and Dagmara Otto-Ślusarczyk. "Anticancer Potential of Halogen Derivatives of Methyl 6-Acetyl-5-Hydroxy-2-Methyl-1-Benzofuran-3-Carboxylate." International Journal of Molecular Sciences 26, no. 12 (2025): 5493. https://doi.org/10.3390/ijms26125493.

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The presented results are a continuation of our research on the synthesis and biological properties of halogen benzofuran derivatives, particularly their anticancer potential. We examined the cytotoxicity of two derivatives, methyl 4-chloro-6-(dichloroacetyl)-5-hydroxy-2-methyl-1-benzofuran-3-carboxylate (7) and methyl 6-(dibromoacetyl)-5-methoxy-2-methyl-1-benzofuran-3-carboxylate (8), in the following human cancer cell lines: SW480, SW620, HCT116, HepG2, PC3, A549, and MDA. The MTT assay results showed that compound 7 exhibited the most promising activity against A549 cells, while compound 8

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15

Velíšek, J., and R. Kubec. "S-Substituted cysteine derivatives in production of flavour and colour." Czech Journal of Food Sciences 22, SI - Chem. Reactions in Foods V (2004): S54—S59. http://dx.doi.org/10.17221/10611-cjfs.

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A brief review of our continuous investigations on S-substituted cysteine derivatives is presented herein. It comprises a summary on nonenzymatic (thermal) decomposition of these amino acids as well as on their role in the formation of blue and pink pigments during processing of garlic and onion, respectively. The emphasis is put on four most common derivatives, namely S-methyl-, S-allyl-, S-1-propenyl- and S-propylcysteine sulfoxides (methiin, alliin, isoalliin and propiin, respectively). Our results demonstrate that these sulfur-containing amino acids are the key primary precursors in the fo

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16

Henley, Matthew J., Alayne L. Schroll, Victor G. Young, and George Barany. "Crystal structures of (N-methyl-N-phenylamino)(N-methyl-N-phenylcarbamoyl)sulfide and the corresponding disulfane." Acta Crystallographica Section E Crystallographic Communications 71, no. 11 (2015): 1371–74. http://dx.doi.org/10.1107/s2056989015018289.

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The title compounds, (N-methyl-N-phenylamino)(N-methyl-N-phenylcarbamoyl)sulfide, C15H16N2OS, (I), and (N-methyl-N-phenylamino)(N-methyl-N-phenylcarbamoyl)disulfane, C15H16N2OS2, (II), are stable derivatives of (chlorocarbonyl)sulfenyl chloride and (chlorocarbonyl)disulfanyl chloride, respectively. The torsion angle about the S—S bond in (II) is −92.62 (6)°, which is close to the theoretical value of 90°. In the crystal of (II), non-classical intermolecular C—H...O hydrogen bonds form centrosymmetric cyclic dimers [graph setR22(10)], while inter-dimer C—H...S interactions generate chains exten

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17

Heredia-Moya, Jorge, та Kenneth L. Kirk. "Synthesis of β-(S-methyl)thioaspartic acid and derivatives". Bioorganic & Medicinal Chemistry 16, № 11 (2008): 5908–13. http://dx.doi.org/10.1016/j.bmc.2008.04.069.

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18

Ridha Jaafar, May, Baneen S. Rasool, Asmaa A.Jawad, Abbas K. Abbas, Daniah Muneam Hamid, and ,Reem Husam Al-Tabra. "Synthesis and Biological Activity of a Novel Derivatives of Schiff Base." Al-Nahrain Journal of Science 27, no. 5 (2024): 1–9. https://doi.org/10.22401/anjs.27.5.01.

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Since their discovery, Schiff bases have been essential compounds that can be found in nature or synthesized in laboratories. We synthesized new schiff bases (1-3), namely as 4-{(E)-[4-(chloromethyl)phenyl]diazenyl}-2-{[(4-substituted phenyl)imino]-methyl}phenol. These derivatives are synthesized from the 5-{(E)-[4-(chloromethyl)phenyl]diazenyl}-2-hydroxybenzaldehyde and 4-substituted aniline, such as 4-methyl aniline, 4-chloro aniline,and4-methoxy aniline. Characterization of these compounds by FTIR and 1HNMRspectroscopy. The diffusion method is used to determine how these compounds interact

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19

Holý, Antonín, Ivan Rosenberg, and Hana Dvořáková. "Synthesis of (3-hydroxy-2-phosphonylmethoxypropyl) derivatives of heterocyclic bases." Collection of Czechoslovak Chemical Communications 54, no. 9 (1989): 2470–501. http://dx.doi.org/10.1135/cccc19892470.

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Analogs of the antiviral 9-(S)-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA, I), containing modified heterocyclic base, were prepared from racemic or (S)-N-(2,3-dihydroxypropyl) derivatives II. Compounds II are heated with chloromethylphosphonyl dichloride (XVII), the formed chloromethylphosphonylester chlorides of compounds II react with water to give a mixture of 2'- and 3'-chloromethylphosphonyl derivatives XVIII and XIX, respectively, which on isomerization by boiling with water in the arising acidic medium affords predominantly the 3'-isomer XIX. Treatment of this isomeric mixture

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20

P. R, Kalpana. "Synthesis, Characterisation and Antimicrobial Potential of Novel N-Alkylated Pyrrole Derivatives of Chitosan." Bioscience Biotechnology Research Communications 14, no. 4 (2021): 1730–36. http://dx.doi.org/10.21786/bbrc/14.4.52.

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Chitosan, a cationic biopolymer is a major derivative of chitin. It is biocompatible, non-toxic and environ-friendly material and has broad spectrum antimicrobial activity. However, it is less effective in neutral or basic conditions due to its solubility only in acidic medium. Therefore, chemical modification with suitable groups is necessary to enhance the potency of chitosan. The present study was mainly conducted to explore the effect of structural modifications on antimicrobial potential of chitosan. N-Methyl, N-Ethyl and N-Propyl pyrrole were reacted with N-chloroacyl-6-O-triphenylmethyl

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21

Fleischer, Ivana, and Štefan Toma. "Synthesis of New Chiral 1,2-Disubstituted Ferrocenes." Collection of Czechoslovak Chemical Communications 69, no. 2 (2004): 330–38. http://dx.doi.org/10.1135/cccc20040330.

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Synthesis of six chiral 1,2-disubstituted ferrocene derivatives is described starting from (S)-{[2-(methoxymethyl)pyrrolidin-1-yl]methyl}ferrocene (2) and {[N-((1R,2S)-methoxy-1-methyl-2-phenethyl)-N-methylamino]methyl}ferrocene (3). Oxidation of the (N-substituted aminomethyl)ferrocenes with active MnO2 furnished the corresponding 2-substituted ferrocenecarbaldehydes.

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22

Koperniku, Ana, Maryam Zamiri, and David Grierson. "The Reaction of N-Trimethylsilyl-Substituted Heteroarylamines with Esters and Thioesters: An Efficient Protocol To Access Diheteroarylamides." Synthesis 51, no. 08 (2019): 1779–90. http://dx.doi.org/10.1055/s-0037-1611435.

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The S-benzyl thioester and methyl ester derivatives of a representative 4-pyridinone-based carboxylic acid were sufficiently activated to react efficiently in amide coupling reactions with the amide anion generated in situ from the N-trimethylsilyl derivative of different weakly nucleophilic heteroarylamines. In acetonitrile as solvent, the precipitated diheteroarylamide products were isolated in pure form by vacuum filtration. This simple amide bond forming protocol can be readily adapted to the parallel synthesis of compound libraries.

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23

Mijajlovic, Marina Z., Milos V. Nikolic, Dusan Lj Tomovic, et al. "Synthesis and Characterization of Platinum (IV) complexes with S-alkyl Derivatives of Thiosalicylic Acid and the Crystal Structure of the S-butyl Derivative of Thiosalicylic Acid." Serbian Journal of Experimental and Clinical Research 18, no. 3 (2017): 195–201. http://dx.doi.org/10.1515/sjecr-2016-0094.

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Abstract New platinum(IV)-complexes with S-alkyl derivatives of thiosalicylic acid (alkyl = benzyl-(L1), methyl-(L2), ethyl-(L3), propyl-(L4), butyl-(L5)) have been synthesized and characterized by microanalysis, infrared spectroscopy, and 1H and 13C NMR spectroscopy. Th e bidentate S,O ligand precursor, the S-butyl derivative of thiosalicylic acid (S-bu-thiosal), was prepared, and its crystal structure was determined. Single crystals suitable for X-ray measurements were obtained by slow crystallization from a DMSO-water system. S-bu-thiosal crystallized in a P21/c space group of a monoclinic

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24

Chalupová, Šárka, Antonín Holý, and Milena Masojídková. "Synthesis of Some N4-Substituted Derivatives of 1-[(S)-3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC, Cidofovir)." Collection of Czechoslovak Chemical Communications 70, no. 12 (2005): 2053–65. http://dx.doi.org/10.1135/cccc20052053.

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N4-Substituted derivatives of HPMPC were synthesized in four-step synthesis which included treatment of 4-methoxypyrimidin-2(1H)-one (1) with (S)-[(trityloxy)methyl]oxirane in DMF. Condensation of intermediary 1-[2-hydroxy-3-(trityloxy)propyl]-4-methoxypyrimidin-2(1H)-one (2) with (diisopropoxyphosphoryl)methyl tosylate in the presence of sodium hydride resulted in fully protected 4-methoxypyrimidin-2(1H)-one derivative 3 which gave on reaction with an appropriate primary amine in dioxane N4-substituted products 4a-4i. The reaction with bromotrimethylsilane simultaneously cleaved the trityl gr

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25

Nizamov, Ilyas S., Ildus D. Timushev, Ramazan Z. Salikhov, et al. "Pyridine Alkaloid Derivatives of Dithiophosphoric Acids and Their Antimicrobial Evaluation." Asian Journal of Chemistry 32, no. 2 (2019): 329–34. http://dx.doi.org/10.14233/ajchem.2020.22381.

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A new series of (S)-(–)-nicotinium salts of cyclic dithiophosphoric acids were synthesized by the reactions of 5,5-dimethyl-2-mercapto-2-thiono-1,3,2-dioxaphosphorinane and 4-methyl-2-mercapto-2-thiono-1,3,2-dioxaphosphorinane with (S)-(–)-nicotine. Picolinic and nicotinic acids and potassium pyridine-3-carboxylate reacted with O,O-diterpenyl dithiophosphoric acids on the basis of (1R)-endo-(+)-fenchyl alcohol and (S)-(–)-menthol to afford the corresponding 2-carboxypyridinium, 3-carboxypyridinium and potassium pyridinium-3-carboxylate dithiophosphates. The antibacterial and antifungal activit

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26

Kulhánek, Jiří, Oldřich Pytela, and Antonín Lyčka. "Chemometrical Analysis of Substituent Effects. XIII. Comparison of Substituent Effects on Dissociation and Chemical Shift in 13C NMR Spectra of Mono- and Disubstituted Benzoic Acids." Collection of Czechoslovak Chemical Communications 65, no. 1 (2000): 106–16. http://dx.doi.org/10.1135/cccc20000106.

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The 13C chemical shifts have been measured of the carboxyl carbon atoms for all the 2-, 3-, and 4-substituted benzoic acids with H, CH3, CH3O, F, Cl, Br, I, and NO2 substituents, as well as for all 3,4-, 3,5-, and 2,6-disubstituted benzoic acids with combinations of CH3, CH3O, Cl (or Br), NO2 substituents and for symmetrically 2,6-disubstituted derivatives with Et, EtO, PrO, i-PrO, and BuO substituents. The chemical shifts of carboxylic group carbon atoms of the 3- and 4-substituted derivatives show correlation only with the substituent constants σI. For the 2-substituted derivatives was found

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27

Karpenko, Yu V., O. I. Panasenko, S. M. Kulish, and A. V. Domnich. "Synthesis and acute toxicity of new S-derivatives (1,2,4-triazole-3(2H)-yl)methyl) thiopyrimidines." Current issues in pharmacy and medicine: science and practice 16, no. 2 (2023): 158–64. http://dx.doi.org/10.14739/2409-2932.2023.2.274586.

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In the literature, there is insufficient information on the synthesis of compounds in a series of pyrimidine-2-thiol derivatives containing a five-membered nitrogen-containing heterocyclic fragment; at the same time, there are a sufficient number of examples, demonstrating the synthetic and biological potential for compounds of this kind. The relevance of the study “structure – acute toxicity” relationship in a number of newly synthesized derivatives of 1,2,4-triazole-3(2H)-thione with pyrimidine-2-thiol is due to the synthesis of potential low molecular weight interferon inducers and antitumo

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28

Gurka, Donald F., Fred L. Shore, and Shu-Teh Pan. "Pentafluorobenzylation Derivatization for Determination of Chlorinated Herbicide Acids." Journal of AOAC INTERNATIONAL 70, no. 5 (1987): 889–91. http://dx.doi.org/10.1093/jaoac/70.5.889.

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Abstract Pentafluorobenzyl and methyl esterification methods for several common herbicide acids have been evaluated and compared. Gas chromatography,' electron capture instrumental detection limits for 2 of 7 pentafluorobenzyl esters were better than the corresponding methyl esters, and comparable for the other S herbicide esters. The linear dynamic concentration range was generally wider for the methyl esters. Gas chromatography of some pentafluorobenzyl derivatives was complicated by coelution of certain derivatives with each other and with byproducts of the derivatization reaction. The rugg

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29

Huang, Xiaoling, Barry J. Blackburn, Steve C. F. Au-Yeung, and Alexander F. Janzen. "Fluorination of sulfur-containing amino acids: Reaction of xenon difluoride with cysteine derivatives." Canadian Journal of Chemistry 68, no. 3 (1990): 477–79. http://dx.doi.org/10.1139/v90-072.

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The reaction of XeF2 with cysteine derivatives RSCH2CH(NHR)COOR, i.e., S-benzyl-N-trifluoroacetyl-L-cysteine methyl ester, S-benzyl-N-carbobenzoxy-L-cysteine p-nitrophenyl ester, and S-methyl-N-trifluoroacetyl-L-cysteine methyl ester is described. The fluorinated products PhCHFSCH2CH(NHR)COOR, PhCH2SCHFCH(NHR)COOR, and FCH2SCH2CH(NHR)COOR were identified by 1H and 19F nuclear magnetic resonance spectroscopy. PhCH2SCHFCH(NHR)COOR loses HF within 24 hours to give Z- and E-PhCH2SCH=C(NHR)COOR. If the reaction with XeF2 is carried out in the presence of moisture the sulfoxide RS(O)CH2CH(NHR)COOR a

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30

Janeba, Zlatko, Antonín Holý, and Milena Masojídková. "Synthesis of Acyclic Nucleoside and Nucleotide Analogs Derived from 6-Amino-7H-purin-8(9H)-one." Collection of Czechoslovak Chemical Communications 65, no. 7 (2000): 1126–44. http://dx.doi.org/10.1135/cccc20001126.

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Reaction of 8-bromoadenine derivatives 2 with sodium acetate in acetic acid and cleavage of (S)-7-[(trityloxy)methyl]-7,8-dihydro[1,3]oxazolo[3,2-e]purin-4-amine (12) and diisopropyl (S)-{[(4-amino-8,9-dihydro-7H-[1,3]oxazino[3,2-e]purin-8-yl)oxy]methyl}phosphonate (13a) were used for the synthesis of the corresponding N9-substituted derivatives of 6-amino- 7H-purin-8(9H)-one 3a-3c and 7. Alkylation of 6-amino-7H-purin-8(9H)-one (3a) with diverse alkylation agents afforded the title N9-monosubstituted 3b, 3d and 7a and N7,N9-disub- stituted acyclic nucleoside and nucleotide analogs 6b, 6d and

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Stradella, Omar G., Hugo O. Villar, and Eduardo A. Castro. "A theoretical conformational study of s-tetrathiane, s-tetroxane and their methyl derivatives." Journal of Molecular Structure: THEOCHEM 135 (February 1986): 7–14. http://dx.doi.org/10.1016/0166-1280(86)80042-2.

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32

Kutschy, Peter, Mojmír Suchý, Milan Dzurilla, Mitsuo Takasugi, and Vladimír Kováčik. "A New Approach to Imidazo[1,5-a]indole Derivatives." Collection of Czechoslovak Chemical Communications 65, no. 7 (2000): 1163–72. http://dx.doi.org/10.1135/cccc20001163.

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Reaction of indole-2-carbonyl isothiocyanate (1) with sodium methanethiolate afforded 1-thioxo-1H-imidazo[1,5-a]indol-3(2H)-one (3). Its methylation with methyl iodide in the presence of lithium hydride in dimethylformamide, or potassium carbonate in acetone resulted in the formation of corresponding S- and N-methyl derivatives 4 and 5. N-(Indole-2-carbonyl)thiocarbamates and N-(indole-2-carbonyl)thioureas prepared by treatment of isothiocyanate 1 with corresponding nucleophilic reagents were S-methylated with methyl iodide in acetone in the presence of potassium carbonate. The obtained N-(ind

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33

Ragan, Mark A. "The high molecular weight polyphloroglucinols of the marine brown alga Fucusvesiculosus L.: degradative analysis." Canadian Journal of Chemistry 63, no. 2 (1985): 294–303. http://dx.doi.org/10.1139/v85-050.

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The high-molecular-weight polyphloroglucinol tannin of Fucusvesiculosus has been islated in pure form as judged by 1H and 13C nmr. Acetate and methyl derivatives were prepared and examined by uv and ir spectroscopy. Calcium – liquid ammonia degradation of the methyl ether derivative liberated numerous aryl compounds including fragments arising from ether-linked phloroglucinol end groups, internal ortho-, meta-, and para-oriented diethers, vic- and (tentatively identified) sym-triethers, internal phloroglucinol-derived biphenyls (three isomers), probable terminal biphenyls, terphenyl(s), and fr

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34

Solet, Sanwar Mal, Neetesh Kumar Sharma, and Raghvendra Singh Bhadauria. "Biological Evaluation of Novel Synthesized 2, 5-disubstituted-1, 3, 4-oxadiazole derivatives." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 573–76. http://dx.doi.org/10.22270/jddt.v9i4-a.3522.

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Synthesis of a series of various 2, 5-disubstituted-1, 3, 4-oxadiazole derivatives (7a-7v) have been done previously. These novel synthesized derivatives (7a-7v) have been tested for their antibacterial activity against Gram +ve S. aureus and Gram -ve E. Coli bacterias by broth dilution method. A comparative study has been done for all derivatives. Based on the visual turbidity, the MIC of the evaluated molecules has been studied, the evaluation concentration was used single therefore, the exact MIC could not determined and results are represented in less than and more than based on growth of

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35

Mohammed, Tiba Ibrahim. "Synthesis of New Azo–Schiff Base Complexes and Study of their Antibacterial Activity." International Journal Papier Advance and Scientific Review 4, no. 1 (2023): 42–56. http://dx.doi.org/10.47667/ijpasr.v4i1.206.

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In this research, we synthesized new azo-schiff base derivatives (4-9). These derivatives of azo compounds (1-3) that synthesized from 4-ethoxyaniline and drivatives of aldehyde such as, 4-aminobenzaldehyde, 4- hydroxybenzaldehyde and 4-ethoxybenzaldehyse to produce azo compounds (1-3). The compounds (1-3) reacted with differents aldehyde such as, isonicotinic hydrazide to produce N'-[(Z)-{3-[(E)-(4-ethoxyphenyl)diazenyl]-4-subs.phenyl}-methylidene]pyridine-4-carbohydrazide derivatives (4-6) and 3-amino pyridine to produce 2-[(E)-(4-ethoxyphenyl)diazenyl]-4-{(E)-[(pyridin-3-yl)imino]-methyl}su

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36

Nikolic, Milos V., Marina Z. Mijajlovic, Dusan Lj Tomovic, et al. "Synthesis and Characterization of Zinc(II)-Complexes with S-Alkyl Derivatives of Thiosalicylic Acid." Serbian Journal of Experimental and Clinical Research 19, no. 2 (2018): 113–17. http://dx.doi.org/10.1515/sjecr-2017-0005.

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Abstract New zinc(II)-complexes with S-alkyl derivatives of thiosalicylic acid (alkyl = benzyl-(L1), methyl-(L2), ethyl-(L3), propyl-(L4), butyl-(L5)) have been synthesized and characterized by elemental microanalysis, IR spectroscopy, and 1H and 13C NMR spectroscopy. The S-alkyl derivatives of thiosalicylic acid were prepared by alkylation of thiosalicylic acid by adding alkyl halides to an alkaline water-ethanol solution, while the corresponding zinc(II)-complexes were obtained via the direct reaction of ZnCl2 with S-alkyl derivatives of thiosalicylic acid in water. Based on the microanalysi

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37

Bhabhor, Falguni, K. Satish, Hiren Variya, and Vikram Panchal. "Synthesis and Biologically Important of 2-Mercaptobenthiazole (MBT)-Clubbed Chalcone Derivatives." International Letters of Chemistry, Physics and Astronomy 63 (January 2016): 83–89. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.63.83.

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In this present work base catalyzed method used for formation of Chalcone of (E)-4-(3-(4-hydroxyphenyl) acryloyl)-5-methyl-2(p-tolyl)-1H-pyrazol-3(2H)-one (II) reacted with derivatives of S-benzo [d] thiol-2yl-2-chloroethanethioate (Ia-f) resulted in formation of corresponding derivatives of (E)-S-benzo [d] thiazol-2-yl 2-(4-(3-(5-methyl-3oxo-2(p-tolyl)-2,3-dihydro-1H-pyrazol-4-yl)-3-oxoprop-1-en-1-yl) phenoxy) etanethioate (IIIa-f) was confirmed by spectral characterization such as IR,1H NMR, LC-MS and elemental analysis. The compounds were screened for their antimicrobial properties against

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Bhabhor, Falguni, K. Satish, Hiren Variya, and Vikram Panchal. "Synthesis and Biologically Important of 2-Mercaptobenthiazole (MBT)-Clubbed Chalcone Derivatives." International Letters of Chemistry, Physics and Astronomy 63 (January 4, 2016): 83–89. http://dx.doi.org/10.56431/p-8hbuet.

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In this present work base catalyzed method used for formation of Chalcone of (E)-4-(3-(4-hydroxyphenyl) acryloyl)-5-methyl-2(p-tolyl)-1H-pyrazol-3(2H)-one (II) reacted with derivatives of S-benzo [d] thiol-2yl-2-chloroethanethioate (Ia-f) resulted in formation of corresponding derivatives of (E)-S-benzo [d] thiazol-2-yl 2-(4-(3-(5-methyl-3oxo-2(p-tolyl)-2,3-dihydro-1H-pyrazol-4-yl)-3-oxoprop-1-en-1-yl) phenoxy) etanethioate (IIIa-f) was confirmed by spectral characterization such as IR, 1H NMR, LC-MS and elemental analysis. The compounds were screened for their antimicrobial properties against

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39

Norton, AK, та M. Vonitzstein. "The Synthesis of 6-Substituted Methyl 1-O-Acetyl-3,4-anhydro-β-D-Tagatofuranosides. Regioselective Chlorination and Thioacetylation in the Presence of an Oxiran". Australian Journal of Chemistry 49, № 3 (1996): 281. http://dx.doi.org/10.1071/ch9960281.

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Methyl 1-O-acetyl-6-S-acetyl-3,4-anhydro-6-thio-β-D-tagatofuranoside (the 1-acetate of (2)) and methyl 1-O-acetyl-3,4-anhydro-6-chloro-6-deoxy-β-D-tagatofuranoside (the 1-acetate of (3)) have been prepared as fructose derivatives by treatment of methyl 3,4-anhydro-β-D-tagatofuranoside (1) with (p-dimethylaminophenyl ) diphenylphosphine/diisopropyl azodicarboxylate/thioacetic S-acid and (p- dimethylaminophenyl ) diphenylphosphine/tetrachloromethane respectively. The reactions proceed in good yield, under mild conditions, and are selective for the 6-hydroxy group. The oxiran ring is unaffected u

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40

Schaefer, Ted, Rudy Sebastian, Salman R. Salman, James D. Baleja, Glenn H. Penner, and David M. McKinnon. "The proximate coupling constant, 5J(H,CH3), and the torsional mobility of the thiomethyl group in some thioanisole derivatives." Canadian Journal of Chemistry 69, no. 4 (1991): 620–24. http://dx.doi.org/10.1139/v91-094.

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The proximate coupling constants, 5J, between ortho and methyl protons in thioanisole and 18 of its derivatives are discussed as conformational indicators. On the assumption that 5J varies as cos4θ, for 0° ≤ θ ≤ 90°, θ being the angle by which the methyl group twists out of the aromatic plane, 5J for θ = 0° follows as −0.43 (2) Hz from the known internal barrier in thioanisole in solution. A measurement of 5J in meta- or para-substituted thioanisole derivatives then yields an approximate value for the twofold barrier to rotation about the Csp2—S bond. For derivatives containing an ortho substi

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41

Shakurova, Elvira R., and Lyudmila V. Parfenova. "Synthesis of N-Heterocyclic Analogues of 28-O-Methyl Betulinate, and Their Antibacterial and Antifungal Properties." Molbank 2020, no. 1 (2019): M1100. http://dx.doi.org/10.3390/m1100.

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The paper presents the results on the one-pot pyridine quaternization using betulinic 28-O-methyl ester (1) and Tempo+Br3− cation followed by reduction of the resulting salt (2) to 1,2,5,6-tetrahydropyridine derivative (3). The structures of new compounds are confirmed by means of 1D and 2D-NMR spectroscopy, as well as MALDI TOF/TOF spectrometry. The derivatives 2 and 3 are active against S. aureus at the minimum inhibitory concentration (MIC) of 4 μg/mL and 16 μg/mL, correspondingly.

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Krečmerová, Marcela, Milena Masojídková, and Antonín Holý. "Preparation of C-5 Substituted Cidofovir Derivatives." Collection of Czechoslovak Chemical Communications 71, no. 4 (2006): 579–94. http://dx.doi.org/10.1135/cccc20060579.

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1-[(S)-3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC, cidofovir) was modified by substitution on the base moiety in positions C-5 and N4. Key intermediates of these syntheses, diisopropyl esters of (S)-1-[2-(phosphonomethoxy)-3-(triphenylmethoxy)propyl]-5-alkylcytosines (6 and 7) prepared from 5-alkyl-4-methoxypyrimidin-2(1H)-ones were transformed to the corresponding 5-substituted cytosine or N4-alkylcytosine derivatives by the action of ammonia or primary amines, respectively. These fully protected phosphonate esters gave by treatment with bromotrimethylsilane followed by hydrolysis f

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43

Draman, Rafie. "Hirshfeld Surface Investigation of Intermolecular Interaction of N-Aroyl-N’-(2-pyridyl)thiourea Derivatives." ASM Science Journal 15 (May 17, 2021): 1–7. http://dx.doi.org/10.32802/asmscj.2020.495.

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A detailed analysis of the intermolecular interactions of the crystalline structure of thiourea derivatives namely 1-(3-Methylbenzoyl)-3-(6-methyl-2-pyridyl)-thiourea, N-(2-Furoyl)-N’-(6-methyl-2-pyridyl)thiourea, 2-Methyl-N-[(3-methyl-2-pyridyl)-carbamothioyl]benzamide and 1-(4-Chlorobenzoyl)-3-(3-methylpyridin-2-yl)thiourea have been performed based on the Hirshfeld surfaces and their associated two-dimensional fingerprint plots. The result showed that the structures were stabilized by H···H, H···S, O···H, N···H, C–H···π, and π···π intermolecular interactions, which contribute mostly to the

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44

Variya, Hiren H., Vikram Panchal, Falguni G. Bhabhor, and G. R. Patel. "Synthesis and Characterization of Biologically Potent Chalcone Bearing 1,3,4-Oxadiazole Linkage." International Letters of Chemistry, Physics and Astronomy 61 (November 2015): 77–83. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.61.77.

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In this article, we have described to design and synthesized a series of substituted chalcone based 1,3,4-oxadiazole derivatives. Titled compounds (E)-S-(-5-phenyl-1,3,4-oxadiazol-2-yl) 2-(4-(3-(5-methyl-3oxo-2(p-tolyl)-2,3-dihydro-1H-pyrazol-4-yl)-3-oxoprop-1-en-1-yl) phenoxy) etanethioate (III1-6) were synthesized using of derivatives of S-(-5-phenyl-1,3,4 oxadiazole-2-yl)2-chloroethaethioate (I1-6) were reacted with (E)-4-(3-(4-hydroxyphenyl) acryloyl)-5-methyl-2(p-tolyl)-1H-pyrazol-3(2H)-one (II) in presence of K2CO3 in DMF as a solvent. The synthesized compounds were evaluated for their a

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45

Variya, Hiren H., Vikram Panchal, Falguni G. Bhabhor, and G. R. Patel. "Synthesis and Characterization of Biologically Potent Chalcone Bearing 1,3,4-Oxadiazole Linkage." International Letters of Chemistry, Physics and Astronomy 61 (November 3, 2015): 77–83. http://dx.doi.org/10.56431/p-x4q61z.

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In this article, we have described to design and synthesized a series of substituted chalcone based 1,3,4-oxadiazole derivatives. Titled compounds (E)-S-(-5-phenyl-1,3,4-oxadiazol-2-yl) 2-(4-(3-(5-methyl-3oxo-2(p-tolyl)-2,3-dihydro-1H-pyrazol-4-yl)-3-oxoprop-1-en-1-yl) phenoxy) etanethioate (III1-6) were synthesized using of derivatives of S-(-5-phenyl-1,3,4 oxadiazole-2-yl)2-chloroethaethioate (I1-6) were reacted with (E)-4-(3-(4-hydroxyphenyl) acryloyl)-5-methyl-2(p-tolyl)-1H-pyrazol-3(2H)-one (II) in presence of K2CO3 in DMF as a solvent. The synthesized compounds were evaluated for their a

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46

Chênevert, Robert, and Linda D'astous. "Enzyme catalysed hydrolysis of chlorophenoxypropionates." Canadian Journal of Chemistry 66, no. 5 (1988): 1219–22. http://dx.doi.org/10.1139/v88-199.

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We report on the enzymatic hydrolysis of methyl 2-phenoxypropionate and of the following chlorinated derivatives: methyl o-chloro-, m-chloro-, p-chloro-, and o,p-dichloro-2-phenoxypropionates. α-Chymotrypsin, lipase, and pig liver esterase have an R enantioselectivity whereas subtilisin has an S enantioselectivity. Enantiomeric excesses (e.e.) cover a wide range (from 5 to 100%).

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47

Lukevics, Edmunds, Edgars Abele, Pavel Arsenyan, et al. "Synthesis and Cytotoxicity of Silicon Containing Pyridine and Quinoline Sulfides." Metal-Based Drugs 9, no. 1-2 (2002): 45–51. http://dx.doi.org/10.1155/mbd.2002.45.

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Silicon containing pyridine and quinoline sulfides have been prepared using phase transfer catalytic system thiol/alkyl halide / solid KOH/18-crown-6 / toluene. The target S-ethers were isolated in yields up to 81%. The cytotoxicity of the synthesized compounds was studied. Among pyridine sulfides S-[3-(1-methyl- 1-silacyclohexyl)propyl] derivatives 5e and 6e exhibit the highest cytotoxicity. Aliphatic silicon derivatives were considerably less active. 8-[(Trimethylsilylmethyl)thio]quinoline (8a) exhibits the highest activity among quinoline sulfides.

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48

Idrees, M., Naqui J. Siddiqui, Yogita G. Bodkhe, and Satish Kola. "Synthesis and Characterization of Novel 1,3,5-Thiadiazine Derivatives Integrated with Quinoline Moiety as Potent Antimicrobial Agents." Asian Journal of Organic & Medicinal Chemistry 5, no. 2 (2020): 149–55. http://dx.doi.org/10.14233/ajomc.2020.ajomc-p262.

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An expeditious synthesis of series of novel 1,3,5-thiadiazine (5a-f) and (6a-f) derivatives have been described. These compounds were synthesized by reaction of 1-(N-((6-methyl-2-(p-tolyloxy)quinoline- 3-yl)methylene)carbamimidoyl)-3-arylthiourea (3a-b) derivatives with N-aryl isocyanodichloride (4a-c) in chloroform followed by basification with dilute NH4OH to give the target compounds 5a-f; which were acetylated further to afford six novel 1,3,5-thiadiazin-3-(6H)-yl)ethanone (6a-f) derivatives. Synthesis of intermediate compounds 3a-b was obtained by reacting 6-methyl-2-(p-tolyloxy)quinoline

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Cambie, Richard C., Maria do Céu Costa, Paul D. Woodgate, et al. "Oxidations of 12-Deoxy-, 12-Hydroxy-, 12-Methoxy-, and 12-Hydroxy-13-methoxy-podocarpa-8,11,13-triene Derivatives." Australian Journal of Chemistry 51, no. 1 (1998): 37. http://dx.doi.org/10.1071/c97046.

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Methods for the oxidation of the aryl ring of derivatives of podocarpic acid have been examined. Oxidation of methyl 12-hydroxypodocarpa-8,11,13-trien-19-oate (2) with phenyliodonium diacetate in various solvents gives 8β-substituted dienones. An 8β-chloro dienone is formed during oxidation of the phenol (2) with t-butyl hypochlorite. Oxidation of (2) with dimethyldioxiran gives mainly the 7-ketone (13) but also affords the novel ε-lactone (26), while treatment with ruthenium tetraoxide also affords products of benzylic oxidation. Oxidation of methyl podocarpa-8,11,13-trien-19-oate (4) with m-

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50

Karpun, Yevhen, and Nataliia Polishchuk. "Synthesis and antimicrobial activity of s-substituted derivatives of 1,2,4-triazol-3-thiol." ScienceRise: Pharmaceutical Science, no. 3(31) (June 30, 2021): 64–69. http://dx.doi.org/10.15587/2519-4852.2021.235976.

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The aim of the work. 1,2,4-triazole derivatives possess a wide range of pharmacological activity, so they are used for the development of drugs and active pharmaceutical ingredients. Due to the reactivity of 1,2,4-triazoles there are many options for their further structural modification on different reaction centers. Therefore, the aim of the work was to obtain new S-substituted derivatives of 1,2,4-triazole-3-thiols, study physicochemical parameters of the substances synthesized, evaluate the antimicrobial activity of new S-derivatives of the 4-R1-5-((3-(pyridin-4-yl)-1H-1,2,4-triazol-5-yl)t

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