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Dissertations / Theses on the topic 'S100A12'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Goyette, Jesse Davis Medical Sciences Faculty of Medicine UNSW. "The extracellular functions of S100A12." Publisher:University of New South Wales. Medical Sciences, 2008. http://handle.unsw.edu.au/1959.4/41302.

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The S100s comprise a group of Ca2+-binding proteins of the EF-hand superfamily with varied functions. Within this family, three inflammatory-related proteins - S100A8, S100A9 and S100A12 - form a subcluster known as the 'calgranulins'. S100A12 levels are elevated in sera from patients with inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease. S100A12 is constitutively expressed in neutrophils and induced in monocytes by LPS and TNFα, and in macrophages by IL-6. S100A12 is a potent monocyte and mast cell chemoattractant and its potentiation of mast cell activation

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2

Moroz, Olga. "Structural studies on human S100A12." Thesis, University of York, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403963.

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3

Chapeton, Montes Julie Andrea. "Caractérisation des voies alternatives de sécrétion des protéines S100A8/A9 et S100A12 par les neutrophiles humains." Master's thesis, Université Laval, 2015. http://hdl.handle.net/20.500.11794/26156.

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Bien que les protéines S100A8/A9 et S100A12 exprimées par les neutrophiles ne possèdent pas de peptide signal, elles sont retrouvées dans le sérum de patients souffrant de diverses maladies inflammatoires. Les mécanismes de sécrétion de ces protéines demeurent peu connus ainsi que les agonistes qui favorisent leur sécrétion. Nous avons donc émis l´hypothèse que plusieurs voies de sécrétion alternative ainsi que plusieurs agonistes des neutrophiles pourraient participer à la libération de ces protéines. Dans un premier temps, nous avons étudié les stimuli capables de provoquer la sécrétion de l

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4

Mossel, Dieuwertje Marije [Verfasser], and Julia [Akademischer Betreuer] Kzhyshkowska. "Epigenetic regulation of S100A9 and S100A12 expression in monocytes-macrophage system in hyperglycemic conditions / Dieuwertje Marije Mossel ; Betreuer: Julia Kzhyshkowska." Heidelberg : Universitätsbibliothek Heidelberg, 2020. http://d-nb.info/1219303100/34.

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5

Mossel, Dieuwertje M. [Verfasser], and Julia [Akademischer Betreuer] Kzhyshkowska. "Epigenetic regulation of S100A9 and S100A12 expression in monocytes-macrophage system in hyperglycemic conditions / Dieuwertje Marije Mossel ; Betreuer: Julia Kzhyshkowska." Heidelberg : Universitätsbibliothek Heidelberg, 2020. http://d-nb.info/1219303100/34.

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6

Dubois, Christelle. "Confirmation de biomarqueurs pour le pronostic du sepsis et développement de tests rapides High plasma level of S100A8/S100A9 and S100A12 at admission indicates a higher risk of death in septic shock patients Top-down and bottom-up proteomics of circulating S100A8/S100A9 complexes in plasma of septic shock patients." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS521.

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Le sepsis est la 3eme cause de mortalité dans les pays occidentaux, avec un taux de mortalité entre 20 et 50% selon la sévérité. La « prédiction » du devenir clinique du patient est essentielle pour établir le traitement le plus adéquat. Quelques protéines marqueurs de l'inflammation ou d'une infection (CRP, procalcitonine) sont citées pour le suivi des patients en clinique mais manquent de spécificité pour le sepsis. D'autre part, les études « omiques » ont permis de générer des listes de biomarqueurs potentiels du pronostic vital du sepsis. En revanche, aucun n'a encore été validé et/ou conf

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7

Citadini, Ana Paula da Silva. "Estudos da dinâmica estrutural da proteína ligante de cálcio S100A12 humana e da lisozima T4." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-05072011-134514/.

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O trabalho ora apresentado foi concebido como tendo dois objetivos. O primeiro, mais geral, foi implementar uma nova metodologia para o estudo de mudanças conformacionais em proteínas, ou seja, de sua dinâmica estrutural. A técnica de marcação de spin sítio dirigida aliada à ressonância paramagnética eletrônica (SDSL-RPE) são os pilares desse novo método que faz, agora, parte do conjunto de técnicas disponíveis no Grupo de Biofísica Molecular Sérgio Mascarenhas do Instituto de Física de São Carlos (USP). O segundo objetivo, mais específico, representou o caminho efetivamente tomado para que se

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8

Reis, Renata Almeida Garcia. "Estudo dinâmico conformacional da proteína calgranulina C (S100A12) mediante interação com íons e receptor RAGE." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/60/60136/tde-03072012-163222/.

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Calgranulina C (S100A12) é membro da família das proteínas S100 \"EF-hands\" que complexam cálcio. A S100A12 humana é expressa predominantemente por granulócitos e é superexpressa em compartimentos inflamatórios. Níveis séricos elevados de S100A12 são encontrados em pacientes acometidos por distúrbios inflamatórios, neurodegenerativos, metabólicos e neoplasias. A S100A12 intracelular existe como um homodímero anti-paralelo. Cada monômero é composto por um \"EF-hand\" clássico, C-terminal (HI - LI - HII), e um \"EF-hand\" N-terminal, o pseudo \"EF-hand\" (HIII - LIII - HIV). Os \"motifs\" são c

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9

Augner, Kerstin Verfasser], and Monika [Akademischer Betreuer] [Pischetsrieder. "Auswirkung nicht-enzymatischer posttranslationaler Modifikationen auf Konstitution, Oligomerisierung und Biofunktionalität von S100A12 / Kerstin Augner. Gutachter: Monika Pischetsrieder." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2013. http://d-nb.info/1054164886/34.

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10

Garcia, Assuero Faria. "Estudo da estabilidade estrutural de uma proteína recombinante ligante de zinco e cálcio - Calgranulina C (S100A12) porcina." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-30042007-141038/.

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S100A12 porcina é um membro da família das proteínas S100, um grupo de pequenas proteínas ligantes de cálcio caracterizado pela presença de dois motivos EF-hand. Estas proteínas estão envolvidas em diversos eventos celulares, como a regulação da fosforilação protéica, atividade enzimática, tamponamento de Ca+2, processos inflamatórios e a polimerização de filamentos intermediários. Adicionalmente, algumas dessas proteínas podem ligar Zn+2, o qual pode afetar a ligação do íon Ca+2, particularmente para as proteínas S100. Neste trabalho, a seqüência gênica que codifica a proteína S100A12 porci

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11

Augner, Kerstin [Verfasser], and Monika [Akademischer Betreuer] Pischetsrieder. "Auswirkung nicht-enzymatischer posttranslationaler Modifikationen auf Konstitution, Oligomerisierung und Biofunktionalität von S100A12 / Kerstin Augner. Gutachter: Monika Pischetsrieder." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2013. http://d-nb.info/1054164886/34.

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12

Brockmeyer, Sonja [Verfasser], and Dirk [Akademischer Betreuer] Föll. "Einfluss der S100A12-Oligomerisierung auf die Interaktion und Aktivierung der Rezeptoren RAGE und TLR-4 / Sonja Brockmeyer ; Betreuer: Dirk Föll." Münster : Universitäts- und Landesbibliothek Münster, 2016. http://d-nb.info/1140169033/34.

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13

Zwicker, Stephanie. "Psoriasin (S100A7) and koebnerisin (S100A15) in the model of inflammation." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-185702.

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14

Einem, Gina Franziska von [Verfasser]. "Eignen sich die Proteine S100a12 und Calprotectin bei kontrastmittelinduziertem Nierenversagen als Biomarker im Urin? : Untersuchung anhand einer prospektiven klinischen Studie / Gina Franziska von Einem." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2015. http://d-nb.info/1079841083/34.

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15

Leukert, Nadja. "Molekulare Charakterisierung verschiedener Komplexformen der Calcium-bindenden Proteine S100A8 und S100A9." [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=967777062.

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16

Raquil, Marie-Astrid. "Études des rôles pro-inflammatoires et prolifératifs des protéines S100A8 et S100A9." Thesis, Université Laval, 2008. http://www.theses.ulaval.ca/2008/25415/25415.pdf.

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17

Sikora, Kristin [Verfasser]. "RAGE-abhängige S100A8- und S100A9-Expression in humanen THP-1 Zellen / Kristin Sikora." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2009. http://d-nb.info/1023749920/34.

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18

Defrêne, Joan. "Fonctions des protéines S100A8 et S100A9 dans la réponse inflammatoire associée aux maladies auto-immunes." Doctoral thesis, Université Laval, 2020. http://hdl.handle.net/20.500.11794/66869.

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De nos jours, les maladies auto-immunes concernent une part grandissante de la population mondiale et s’accompagnent d’une comorbidité importante, mais aussi d’un lourd fardeau économique. Parmi ces maladies les plus courantes, on distingue l'arthrite rhumatoïde et le psoriasis affectant respectivement les articulations et la peau et qui ne possèdent toujours pas de traitements curatifs. Dans la pathogenèse de ces maladies, une forte réponse inflammatoire est notamment générée et entretenue, contribuant ainsi à la dégradation des tissus ciblés. De nombreux marqueurs de l’inflammation sont sécr

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19

Laouedj, Malika. "Effets des protéines S100A8 et S100A9 dans la différenciation cellulaire dans la leucémie myéloïde aiguë." Doctoral thesis, Université Laval, 2017. http://hdl.handle.net/20.500.11794/27761.

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Tableau d’honneur de la Faculté des études supérieures et postdoctorales, 2016-2017<br>Les leucémies myéloïdes aiguës (LMA) sont des hémopathies rares, mais très agressives. Elles résultent d’un dérèglement du processus d’hématopoïèse qui se caractérise par une prolifération incontrôlée de cellules sanguines immatures engagées dans la lignée myéloïde. En dépit des traitements actuels qui reposent sur l’utilisation d’agents chimiothérapeutiques ciblant les cellules en prolifération, le pronostic des patients souffrants de LMA est très sombre. En effet, seuls 30% des patients souffrants de LMA s

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20

Belot, Nathalie. "Caractérisation du rôle des protéines S100A4 et S100A6 dans la migration de cellules gliales tumorales." Doctoral thesis, Universite Libre de Bruxelles, 2004. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/211198.

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21

Betz, Christine [Verfasser], and Oliver [Akademischer Betreuer] Einsle. "Structural characterization of the metal-binding ligands S100A8/S100A9 and S100B of the receptor for advanced glycation end products = Strukturelle Charakterisierung der metallbindenden Liganden S100A8/S100A9 und S100B des Rezeptors für Advanced Glycation End Products." Freiburg : Universität, 2013. http://d-nb.info/1115813455/34.

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22

Zwicker, Stephanie [Verfasser], and Ronald [Akademischer Betreuer] Wolf. "Psoriasin (S100A7) and koebnerisin (S100A15) in the model of inflammation : functional characterization in the inflammation cascade / Stephanie Zwicker. Betreuer: Ronald Wolf." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2014. http://d-nb.info/1075456991/34.

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23

Malamis, Dimitrios. "Systemic levels of inflammatory mediators in periodontitis." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1436961245.

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24

Okada, Kouki. "CD68 on rat macrophages binds tightly to S100A8 and S100A9 and helps to regulate the cells’ immune functions." 京都大学 (Kyoto University), 2017. http://hdl.handle.net/2433/225517.

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25

Berrocal, Almanza Luis Carlos [Verfasser]. "The impact of the serum levels of soluble receptor for advanced glycation end products (sRAGE) and its ligand S100A12 for the course and extent of lung involvement in smear positive pulmonary tuberculosis in a cohort study in Hyderabad - India. / Luis Carlos Berrocal Almanza." Berlin : Freie Universität Berlin, 2015. http://d-nb.info/1070570729/34.

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26

Foulkes, T. "The role of p11 (S100A10) in nociception." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1445486/.

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The S100-family protein p11 (S100A10) is involved in a variety of physiological processes, including channel trafficking and angiogenesis. In this thesis, we used genetic approaches to investigate the functional roles of p11. p11 modulates the plasma membrane trafficking of the sensory neuron-specific voltage-gated Na" channel Nay 1.8 and numerous other proteins. Since Nav1.8 performs a specialised function in the detection of noxious stimuli (nociception), we investigated the role of p11 in peripheral pain pathways. We used the Ctq-IoxP system to delete p11 exclusively from nociceptive neuron

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27

Ludwig, Stefan [Verfasser]. "Die S100-Proteine S100A8 und S100A9 sowie der Heterodimerkomplex S100A8/A9 im Serum und Plasma als Marker des Prostatakarzinoms : Untersuchungen zu präanalytischen Einflussfaktoren und zur diagnostischen Differenzierung zwischen benigner Prostatahyperplasie und Prostatakarzinom / Stefan Ludwig." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2008. http://d-nb.info/1023022486/34.

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28

Eggers, Kai. "S100A8-S100A9 abhängige Akivierung der RAGE-MAPK-NF-kB-Signaltransduktionssequenz [RAGE-MAPK-NF-kappa-B-Signaltransduktionssequenz] ein neues Modell der chronischen Inflammation am humanen Endothel /." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=974453455.

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Baillet, Athan. "Régulation de l'activité de la NADPH oxydase des neutrophiles par des enzymes du métabolisme du glucose et l'hétérocomplexe S100A8/S100A9 : application à la polyarthrite rhumatoïde." Phd thesis, Université de Grenoble, 2011. http://tel.archives-ouvertes.fr/tel-00680093.

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La Polyarthrite Rhumatoïde est caractérisée par une synovite à l'origine de lésions progressives ostéo-articulaires induites par les formes réactives de l'oxygène (ROS) produites par la NADPH oxydase des polynucléaires neutrophiles (PMN). La NADPH oxydase des phagocytes, est formée d'un centre catalytique membranaire, le cytochrome b558, sur lequel vient s'associer des protéines cytosoliques régulatrices (p67phox, p47phox, p40phox et Rac1/2). Nous avons étudié la spécificité de l'interaction entre la (6-phosphofructokinase 2) et de la 6PGDH (6-phosphogluconate déshydrogénase) et la NADPH oxyda

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30

Baker, Jonathan Richard. "S100A8 in development." Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/1444146/.

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S100 proteins are a family of Ca2+ binding EF-hand proteins. S100A8 is a cytosolic protein expressed in myeloid cells and epithelia where it forms a stable heterodimer with another S100 protein family member, S100A9. The S100A9 null mouse is viable and has no gross defect whereas the S100A8 null mouse is embryonic lethal. It was originally proposed that the S100A8 null mouse is lethal at E 9.0 in development due to lack of expression at E 6.5 in ectoplacental cone cells. This thesis shows that the S100A8 null phenotype is more complex than originally thought. S100A8 has a role in preimplantati

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31

Herwig, Nadine. "Der RAGE-Ligand S100A4." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-214035.

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Das maligne Melanom zählt zu den aggressivsten und behandlungsresistentesten aller Krebsarten. In den letzten 20 Jahren hat sich die Rate der Melanom-Erkrankungen innerhalb der weißen Bevölkerung verdreifacht. Mittlerweile liegen eine Reihe von Untersuchungen zu den molekularbiologischen Mechanismen der Entwicklung und Progression des malignen Melanoms vor. Aktuelle Forschungsvorhaben beschäftigen sich vor allem mit der Identifizierung Melanom-spezifischer Biomarker, die diagnostische und prognostische Informationen liefern sowie die Entwicklung einer zielgerichteten, kombinierten und indivi

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32

Myrvang, Helene Karin. "The annexin A2-S100A10 cell surface complex : molecular and functional characterisation." Thesis, University of Nottingham, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.546681.

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33

Meschin, Pierre. "Régulations monoaminergiques AMPc-dépendantes du coeur sain et pathologique." Thesis, Montpellier 1, 2014. http://www.theses.fr/2014MON1T010.

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La fonction cardiaque est finement régulée par des hormones de type monoamines qui constituent des régulateurs cruciaux de l’activité cardiaque (chronotropie et inotropie). Ces hormones dérivées d’acides aminés aromatiques comprenant les catécholamines et la sérotonine maintiennent l’activité du myocarde dans un cadre physiologique tout en lui permettant de s’adapter aux contraintes environnementales. Les récepteurs cellulaires des monoamines sont couplés à des voies de signalisation qui impliquent un nucléotide cyclique, l’AMPc, et modulent la contractilité des cardiomyocytes par l’intermédia

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34

Pietas, Agnieszka. "Identification of the tumour associated gene S100A14 and analysis of its regulation." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=974140813.

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Pietas, Agnieszka. "Identification of the tumour-associated gene S100A14 and analysis of its regulation." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2005. http://dx.doi.org/10.18452/15196.

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Durch Analyse der Subtraktion-cDNA Bibliothek einer humanen Lungentumor Zelllinie haben wir ein neues Mitglied der S100 Genfamilie identifiziert und charakterisiert, welches S100A14 benannt wurde. Die vollständige cDNA hat eine Länge von 1067 bp und kodiert für ein Protein von 104 Aminosäuren, welches die S100-spezifische Kalzium-bindende Domäne enthält. Das Gen wird in normalen humanen Epithelien ubiquitär exprimiert, zeigt jedoch Expressionsverluste in vielen Tumorzelllinien. Im Gegensatz zu Tumorzelllinien ist S100A14 auf mRNA- und Proteinebene in vielen humanen Primärtumoren stärker exprim

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36

Mondet, Julie. "Impacts cliniques et physiopathologiques de l'équilibre redox et de la protéine S100A8 extracellulaire dans les leucémies aiguës myéloïdes de novo de l'adulte (hors LAM3)." Thesis, Université Grenoble Alpes (ComUE), 2018. http://www.theses.fr/2018GREAS007/document.

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Les leucémies aigues myéloïdes (LAM) sont caractérisées par une expansion clonale de cellule(s) souche(s) leucémique(s) bloquée à un stade précoce de maturation. Malgré les avancées thérapeutiques, leur pronostic reste sombre et des progrès thérapeutiques doivent encore être réalisés. Dans les LAM, les espèces réactives de l’oxygène (ROS) sont considérées comme, d’une part, participant à la leucémogenèse et, d’autre part, comme hautement impliquées dans la sensibilité aux chimiothérapies conventionnelles. Par ailleurs, l’équilibre redox qui participe aux dérégulations métaboliques associées au

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37

Jansen, Sandra [Verfasser]. "Expression und Regulation des antimikrobiellen Proteins Psoriasin und S100A15 im ZNS / Sandra Jansen." Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2013. http://d-nb.info/1038602599/34.

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Müller, Irene [Verfasser], Carsten [Akademischer Betreuer] Tschöpe, Sophie Van [Akademischer Betreuer] Linthout, Jens [Gutachter] Kurreck, Roland [Gutachter] Lauster, Carsten [Gutachter] Tschöpe, and Sophie Van [Gutachter] Linthout. "Role of NOD2 and S100A8/S100A9 in the pathogenesis of Coxsackievirus B3-induced myocarditis / Irene Müller ; Gutachter: Jens Kurreck, Roland Lauster, Carsten Tschöpe, Sophie Van Linthout ; Carsten Tschöpe, Sophie Van Linthout." Berlin : Technische Universität Berlin, 2017. http://d-nb.info/1156013542/34.

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Endoh, Yasumi Medical Sciences Faculty of Medicine UNSW. "New mechanisms modulating S100A8 gene expression." Publisher:University of New South Wales. Medical Sciences, 2008. http://handle.unsw.edu.au/1959.4/42942.

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S100A8 is a highly-expressed calcium-binding protein in neutrophils and activated macrophages, and has proposed roles in myeloid cell differentiation and host defense. Functions of S100A8 are not fully understood, partly because of difficulties in generating S100A8 knockout mice. Attempts to silence S100A8 gene expression in activated macrophages and fibroblasts using RNA interference (RNAi) technology were unsuccessful. Despite establishing validated small interfering RNA (siRNA) systems, enzymaticallysynthesized siRNA targeted to S100A8 suppressed mRNA levels by only 40% in fibroblasts activ

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40

McNeill, Eileen. "Neutrophil function in S100A9 null mice." Thesis, University College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.423552.

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41

Nogueira, Thiago de Oliveira. "Efeito antinociceptivo induzido pelo glicogênio em ratos submetidos ao modelo de pressão de pata: relação com a migração neutrofílica e a expressão da proteína S100A9." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/10/10133/tde-08102012-151355/.

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A peritonite neutrofílica induzida por glicogênio acarreta antinocicepção em camundongos submetidos ao teste de contorção abdominal, a qual é mediada por uma proteína ligante de cálcio, com peso molecular de 14 kDa, denominada S100A9. O objetivo do presente trabalho foi aprofundar o estudo sobre o envolvimento dos neutrófilos na antinocicepção induzida pelo glicogênio em ratos submetidos ao teste de pressão de pata e avaliar a expressão da proteína S100A9 nos tempos onde foi detectado esse efeito. O glicogênio induz antinocicepção em ratos entre 2 e 12 horas após sua injeção intraplantar. O p

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Pleger, Sven Torsten. "Entwicklung klinisch experimenteller Ansätze zur therapeutischen Nutzung des kalziumbindenden Proteins S100A1 im Herzen." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=974507091.

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43

Karalekas, Panagiotis. "Is S100A1 involved in the programming effects of fetal hypoxia on cardiac function in chickens?" Thesis, Linköpings universitet, Biologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-111556.

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Prolonged prenatal hypoxia has shown to cause fetal growth restriction inchickens due to restricted oxygen to the somatic tissue. The body goes through a critical periodof development. Insults during this critical period may have lifelong effects on the individual.Currently heart failure is treated either with symptomatic therapy using diuretics or by targetingthe renin-angiotensin-aldosterone system. Developing new successful treatments is importantwith the aging population and the increased rate of heart failure. Previous studies have shownsystolic contractile dysfunction in 5 week old broil

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Moraes, Natassja Foizer. "O C-terminal da proteína S100A9 murina modula os eventos envolvidos na angiogênese e na progressão tumoral em modelos in vitro." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/10/10133/tde-09122015-114330/.

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As proteínas S100A8/A9 são expressas em diferentes tipos celulares e quando sozinhas ou complexadas e em baixas concentrações, promoveram proliferação, migração celular e formação de estruturas capilares. Por outro lado, quando em altas concentrações, esse complexo inibe o crescimento de diversos tipos de células tumorais murinas e humanas. Ainda, tanto a proteína S100A9 humana, quanto um peptídeo sintético idêntico a porção C-terminal da proteína S100A9 murina (pS100A9m) possuem efeitos antinociceptivo e imunorregulatório. Apesar dessas evidencias, até o momento não foi investigado o efeito d

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Sack, Ulrike. "New insights into S100A4-induced colon cancer metastasis." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2011. http://dx.doi.org/10.18452/16313.

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S100A4 spielt eine zentrale Rolle für die Metastasierung des Dickdarmkrebses. Die Hemmung der S100A4 Expression stellt damit einen vielversprechenden therapeutischen Ansatz dar. Die vorliegende Arbeit präsentiert Niklosamid und Calcimycin als neue Inhibitoren der S100A4 Transkription. In Kolonkarzinomzellen, die mit einem der beiden Inhibitoren behandelt wurden, wurde die S100A4 Expression konzentrations- und zeitabhängig unterdrückt. Des Weiteren war die Zellmigration und -invasion in Abhängigkeit von S100A4 in behandelten Zellen vermindert. Niklosamid und Calcimycin Behandlung verhinderten

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Liu, Yidong. "Design, synthesis and evaluation of S100A4 protein inhibitors." Thesis, University of Nottingham, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.738338.

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S100A4 is a 101-amino acid protein belong to a largest sub group of EF-hand calcium binding proteins, and has been described as having both intracellular and extracellular functions. Human S100A4 is the best characterized member of the S100 protein family in terms of its role in cancer and metastasis formation. Overexpression of S100A4 has been observed in several metastatic cancers. It is recognized that an increased level of S100A4 expression correlates with a high incidence of metastasis and poor prognosis for cancer patients. Therefore S100A4 is regarded as a practical target for cancer tr

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Didrihsone, Ieva [Verfasser], and Gudrun [Akademischer Betreuer] Rappold. "S100A1 from Damaged Cardiomyocytes Elicits a Chemoattractant Cardiac Fibroblast Phenotype / Ieva Didrihsone ; Betreuer: Gudrun Rappold." Heidelberg : Universitätsbibliothek Heidelberg, 2017. http://d-nb.info/1180985532/34.

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Bernotat, Juliane. "Beeinflussung der sarkoplasmatischen Ca2+-ATPase-Aktivität im Herz- und Skelettmuskel durch das Ca2+-bindende Protein S100A1." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=974453048.

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Jervis, T. J. "Crystallisation and structural studies of bifunctional enzyme and S100A4." Thesis, Keele University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267460.

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Wache, Christina. "Rolle von S100A8/A9 in der Immunpathogenese der Pneumokokkenmeningitis." Diss., Ludwig-Maximilians-Universität München, 2015. http://nbn-resolving.de/urn:nbn:de:bvb:19-179585.

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