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Dissertations / Theses on the topic 'S100A8'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Betz, Christine [Verfasser], and Oliver [Akademischer Betreuer] Einsle. "Structural characterization of the metal-binding ligands S100A8/S100A9 and S100B of the receptor for advanced glycation end products = Strukturelle Charakterisierung der metallbindenden Liganden S100A8/S100A9 und S100B des Rezeptors für Advanced Glycation End Products." Freiburg : Universität, 2013. http://d-nb.info/1115813455/34.

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2

Leukert, Nadja. "Molekulare Charakterisierung verschiedener Komplexformen der Calcium-bindenden Proteine S100A8 und S100A9." [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=967777062.

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3

van, Hummel Annika Elise. "The Roles of S100A8 and S100A9 in Cartilage: Degradation and Formation." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/11521.

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Osteoarthritis (OA) is a debilitating joint disease that increases in prevalence with age, with latest figures show that around 2.4 million Australians suffer from OA. There are currently no disease-modifying drugs available and due to poor management options, the number of joint replacement surgeries is increasing by nearly 10% per annum in Australia. S100A8 and S100A9 calcium-binding proteins are expressed by immune cells, and are involved in inflammatory situations, including inflammatory diseases such as rheumatoid arthritis, where there is an increase in circulating and local (synovial fl

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4

Baker, Jonathan Richard. "S100A8 in development." Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/1444146/.

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S100 proteins are a family of Ca2+ binding EF-hand proteins. S100A8 is a cytosolic protein expressed in myeloid cells and epithelia where it forms a stable heterodimer with another S100 protein family member, S100A9. The S100A9 null mouse is viable and has no gross defect whereas the S100A8 null mouse is embryonic lethal. It was originally proposed that the S100A8 null mouse is lethal at E 9.0 in development due to lack of expression at E 6.5 in ectoplacental cone cells. This thesis shows that the S100A8 null phenotype is more complex than originally thought. S100A8 has a role in preimplantati

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5

Raquil, Marie-Astrid. "Études des rôles pro-inflammatoires et prolifératifs des protéines S100A8 et S100A9." Thesis, Université Laval, 2008. http://www.theses.ulaval.ca/2008/25415/25415.pdf.

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6

Sikora, Kristin [Verfasser]. "RAGE-abhängige S100A8- und S100A9-Expression in humanen THP-1 Zellen / Kristin Sikora." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2009. http://d-nb.info/1023749920/34.

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7

Ludwig, Stefan [Verfasser]. "Die S100-Proteine S100A8 und S100A9 sowie der Heterodimerkomplex S100A8/A9 im Serum und Plasma als Marker des Prostatakarzinoms : Untersuchungen zu präanalytischen Einflussfaktoren und zur diagnostischen Differenzierung zwischen benigner Prostatahyperplasie und Prostatakarzinom / Stefan Ludwig." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2008. http://d-nb.info/1023022486/34.

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8

Laouedj, Malika. "Effets des protéines S100A8 et S100A9 dans la différenciation cellulaire dans la leucémie myéloïde aiguë." Doctoral thesis, Université Laval, 2017. http://hdl.handle.net/20.500.11794/27761.

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Tableau d’honneur de la Faculté des études supérieures et postdoctorales, 2016-2017<br>Les leucémies myéloïdes aiguës (LMA) sont des hémopathies rares, mais très agressives. Elles résultent d’un dérèglement du processus d’hématopoïèse qui se caractérise par une prolifération incontrôlée de cellules sanguines immatures engagées dans la lignée myéloïde. En dépit des traitements actuels qui reposent sur l’utilisation d’agents chimiothérapeutiques ciblant les cellules en prolifération, le pronostic des patients souffrants de LMA est très sombre. En effet, seuls 30% des patients souffrants de LMA s

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9

Defrêne, Joan. "Fonctions des protéines S100A8 et S100A9 dans la réponse inflammatoire associée aux maladies auto-immunes." Doctoral thesis, Université Laval, 2020. http://hdl.handle.net/20.500.11794/66869.

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De nos jours, les maladies auto-immunes concernent une part grandissante de la population mondiale et s’accompagnent d’une comorbidité importante, mais aussi d’un lourd fardeau économique. Parmi ces maladies les plus courantes, on distingue l'arthrite rhumatoïde et le psoriasis affectant respectivement les articulations et la peau et qui ne possèdent toujours pas de traitements curatifs. Dans la pathogenèse de ces maladies, une forte réponse inflammatoire est notamment générée et entretenue, contribuant ainsi à la dégradation des tissus ciblés. De nombreux marqueurs de l’inflammation sont sécr

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10

Endoh, Yasumi Medical Sciences Faculty of Medicine UNSW. "New mechanisms modulating S100A8 gene expression." Publisher:University of New South Wales. Medical Sciences, 2008. http://handle.unsw.edu.au/1959.4/42942.

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S100A8 is a highly-expressed calcium-binding protein in neutrophils and activated macrophages, and has proposed roles in myeloid cell differentiation and host defense. Functions of S100A8 are not fully understood, partly because of difficulties in generating S100A8 knockout mice. Attempts to silence S100A8 gene expression in activated macrophages and fibroblasts using RNA interference (RNAi) technology were unsuccessful. Despite establishing validated small interfering RNA (siRNA) systems, enzymaticallysynthesized siRNA targeted to S100A8 suppressed mRNA levels by only 40% in fibroblasts activ

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11

Mondet, Julie. "Impacts cliniques et physiopathologiques de l'équilibre redox et de la protéine S100A8 extracellulaire dans les leucémies aiguës myéloïdes de novo de l'adulte (hors LAM3)." Thesis, Université Grenoble Alpes (ComUE), 2018. http://www.theses.fr/2018GREAS007/document.

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Les leucémies aigues myéloïdes (LAM) sont caractérisées par une expansion clonale de cellule(s) souche(s) leucémique(s) bloquée à un stade précoce de maturation. Malgré les avancées thérapeutiques, leur pronostic reste sombre et des progrès thérapeutiques doivent encore être réalisés. Dans les LAM, les espèces réactives de l’oxygène (ROS) sont considérées comme, d’une part, participant à la leucémogenèse et, d’autre part, comme hautement impliquées dans la sensibilité aux chimiothérapies conventionnelles. Par ailleurs, l’équilibre redox qui participe aux dérégulations métaboliques associées au

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12

Dubois, Christelle. "Confirmation de biomarqueurs pour le pronostic du sepsis et développement de tests rapides High plasma level of S100A8/S100A9 and S100A12 at admission indicates a higher risk of death in septic shock patients Top-down and bottom-up proteomics of circulating S100A8/S100A9 complexes in plasma of septic shock patients." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS521.

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Le sepsis est la 3eme cause de mortalité dans les pays occidentaux, avec un taux de mortalité entre 20 et 50% selon la sévérité. La « prédiction » du devenir clinique du patient est essentielle pour établir le traitement le plus adéquat. Quelques protéines marqueurs de l'inflammation ou d'une infection (CRP, procalcitonine) sont citées pour le suivi des patients en clinique mais manquent de spécificité pour le sepsis. D'autre part, les études « omiques » ont permis de générer des listes de biomarqueurs potentiels du pronostic vital du sepsis. En revanche, aucun n'a encore été validé et/ou conf

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13

Okada, Kouki. "CD68 on rat macrophages binds tightly to S100A8 and S100A9 and helps to regulate the cells’ immune functions." 京都大学 (Kyoto University), 2017. http://hdl.handle.net/2433/225517.

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14

Chapeton, Montes Julie Andrea. "Caractérisation des voies alternatives de sécrétion des protéines S100A8/A9 et S100A12 par les neutrophiles humains." Master's thesis, Université Laval, 2015. http://hdl.handle.net/20.500.11794/26156.

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Bien que les protéines S100A8/A9 et S100A12 exprimées par les neutrophiles ne possèdent pas de peptide signal, elles sont retrouvées dans le sérum de patients souffrant de diverses maladies inflammatoires. Les mécanismes de sécrétion de ces protéines demeurent peu connus ainsi que les agonistes qui favorisent leur sécrétion. Nous avons donc émis l´hypothèse que plusieurs voies de sécrétion alternative ainsi que plusieurs agonistes des neutrophiles pourraient participer à la libération de ces protéines. Dans un premier temps, nous avons étudié les stimuli capables de provoquer la sécrétion de l

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15

Wache, Christina. "Rolle von S100A8/A9 in der Immunpathogenese der Pneumokokkenmeningitis." Diss., Ludwig-Maximilians-Universität München, 2015. http://nbn-resolving.de/urn:nbn:de:bvb:19-179585.

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16

Baillet, Athan. "Régulation de l'activité de la NADPH oxydase des neutrophiles par des enzymes du métabolisme du glucose et l'hétérocomplexe S100A8/S100A9 : application à la polyarthrite rhumatoïde." Phd thesis, Université de Grenoble, 2011. http://tel.archives-ouvertes.fr/tel-00680093.

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La Polyarthrite Rhumatoïde est caractérisée par une synovite à l'origine de lésions progressives ostéo-articulaires induites par les formes réactives de l'oxygène (ROS) produites par la NADPH oxydase des polynucléaires neutrophiles (PMN). La NADPH oxydase des phagocytes, est formée d'un centre catalytique membranaire, le cytochrome b558, sur lequel vient s'associer des protéines cytosoliques régulatrices (p67phox, p47phox, p40phox et Rac1/2). Nous avons étudié la spécificité de l'interaction entre la (6-phosphofructokinase 2) et de la 6PGDH (6-phosphogluconate déshydrogénase) et la NADPH oxyda

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17

Eggers, Kai. "S100A8-S100A9 abhängige Akivierung der RAGE-MAPK-NF-kB-Signaltransduktionssequenz [RAGE-MAPK-NF-kappa-B-Signaltransduktionssequenz] ein neues Modell der chronischen Inflammation am humanen Endothel /." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=974453455.

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18

Wache, Christina [Verfasser], and Uwe [Akademischer Betreuer] Ködel. "Rolle von S100A8/A9 in der Immunpathogenese der Pneumokokkenmeningitis / Christina Wache. Betreuer: Uwe Ködel." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2015. http://d-nb.info/1067752447/34.

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19

Bouzidi, Farid. "Rôle de l'hétérodimère S100A8/A9 dans la régulation de l'activité NADPH oxydase des neutrophiles." Université Joseph Fourier (Grenoble), 2002. http://www.theses.fr/2002GRE10127.

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20

Taubert, Teodora [Verfasser]. "S100A8/A9-Charakterisierung eines neuen inflammatorischen Markers in der koronaren Herzerkrankung / Teodora Taubert, geb. Ioanovici." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2012. http://d-nb.info/1026694809/34.

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21

Pepper, R. J. "The role of calprotectin (S100A8/A9) in the pathogenesis of glomerulonephritis and ANCA-associated vasculitis." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1400216/.

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Glomerulonephritis is a common cause of end-stage renal failure and a feature of ANCA-associated vasculitis (AAV). AAV is an example of a small vessel vasculitis, characterised by inflammation of the endothelium and glomeruli in which the interaction between leukocytes and endothelial cells play a crucial role. Macrophages have been demonstrated to have a critical role during the initiation and progression of glomerulonephritis. Calprotectin (also termed S100A8/A9, mrp8/14), is a complex of 2 small calcium binding proteins that is abundantly expressed in neutrophils and monocytes as well as ea

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22

Müller, Irene [Verfasser], Carsten [Akademischer Betreuer] Tschöpe, Sophie Van [Akademischer Betreuer] Linthout, et al. "Role of NOD2 and S100A8/S100A9 in the pathogenesis of Coxsackievirus B3-induced myocarditis / Irene Müller ; Gutachter: Jens Kurreck, Roland Lauster, Carsten Tschöpe, Sophie Van Linthout ; Carsten Tschöpe, Sophie Van Linthout." Berlin : Technische Universität Berlin, 2017. http://d-nb.info/1156013542/34.

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23

Endoh, Ikuko Medical Sciences Faculty of Medicine UNSW. "New mechanisms of regulation of mast cell activation." Publisher:University of New South Wales. Medical Sciences, 2008. http://handle.unsw.edu.au/1959.4/42937.

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Mast cells (MCs) play a central role in inflammation by releasing mediators following activation. S100A8 and S100A9 are abundantly expressed in inflammatory sites such as asthmatic lung, sunburnt skin and atherosclerosis where MCs are involved in pathogenesis; roles of S100A8 in MC function are undetermined. The aims of this thesis were to determine effects of S100A8 on MC activation, particularly provoked by IgE and UVB. Initially, effects of UVB on MC activation were investigated as detailed functions were unclear. Cord blood-derived human mast cells (CBMCs) were treated in vitro with varyin

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24

Kahlert, Andreas Joachim [Verfasser], and Karin [Akademischer Betreuer] Hengst. "Die Funktion der calciumbindenden Proteine S100A8/A9 in der Dissoziation epithelialer Zell-Zell-Kontakte / Andreas Joachim Kahlert. Betreuer: Karin Hengst." Münster : Universitäts- und Landesbibliothek der Westfälischen Wilhelms-Universität, 2012. http://d-nb.info/1027027806/34.

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25

Eisenblaetter, Michel. "Visualisation and monitoring of tumour-mediated immune modulation in primary cancer and premetastatic niche establishment using S100A8/A9-specific imaging." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/visualisation-and-monitoring-of-tumourmediated-immune-modulation-in-primary-cancer-and-premetastatic-niche-establishment-using-s100a8a9specific-imaging(870ae544-5148-4fd8-a1af-bbaa01198b9d).html.

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Development and spread of malignant disease are crucially dependent on the recruitment and reprogramming of various immune cells. At the primary tumour site, tumour-associated macrophages and immature myeloid cells facilitate local invasion and neoangiogenesis and promote the establishment of a tumour-permissive microenvironment. Systemic cancer spread is preceded by the establishment of a permissive microenvironment in the target tissue of metastasis – the premetastatic niche. As crucial players in the establishment of the premetastatic niche as well as the orchestration of tumour immune evas

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26

Yanamandra, Kiran. "Studies of in vivo prostate amyloidosis and autoimmune responses towards amyloid structures in neurodegeneration." Doctoral thesis, Umeå universitet, Institutionen för medicinsk kemi och biofysik, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-37561.

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By using multidisciplinary analysis of CA inclusions in prostate glands of patients diagnosed with prostate cancer, we have revealed that their major components are the amyloid forms of S100A8 and S100A9 proteins associated with numerous inflammatory conditions and types of cancer. We have demonstrated that material closely resembling CA can be produced from S100A8/A9 in vitro and shows the characters of amyloids. This process is facilitated by calcium or zinc, both of which are abundant in ex vivo inclusions. These observations were supported by computational analysis of the S100A8/A9 calcium

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Zwicker, Stephanie. "Psoriasin (S100A7) and koebnerisin (S100A15) in the model of inflammation." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-185702.

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28

Erben, Till [Verfasser]. "Detektion der S100A8/A9 Proteine und des Reg3A Proteins bei entzündlichen und neoplastischen Erkrankungen des Pankreas in Gewebe-, Zellkultur- und Blutproben / Till Erben." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2013. http://d-nb.info/1037798899/34.

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29

Belot, Nathalie. "Caractérisation du rôle des protéines S100A4 et S100A6 dans la migration de cellules gliales tumorales." Doctoral thesis, Universite Libre de Bruxelles, 2004. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/211198.

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30

Baillet, Athan. "Régulation de l'activité de la NADPH oxydase des neutrophiles par des enzymes du métabolisme du glucose et l'hétérocomplexe S100A8/A9 Application à l'étude de la Polyarthrite Rhumatoïde." Phd thesis, Université de Grenoble, 2011. http://tel.archives-ouvertes.fr/tel-00654815.

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La Polyarthrite Rhumatoïde, caractérisée par une synovite à l'origine de lésions progressives ostéo-articulaires, est le plus fréquent des rhumatismes inflammatoires. Les formes réactives de l'oxygène (ROS) produites par la NADPH oxydase des polynucléaires neutrophiles (PMN) infiltrant le pannus rhumatoïde, sont responsables de lésions tissulaires. La NADPH oxydase des phagocytes, est formée d'un centre catalytique membranaire, le cytochrome b558, sur lequel vient s'associer des protéines cytosoliques régulatrices (p67phox, p47phox, p40phox et Rac1/2). L'étude du complexe NADPH oxydase isolé e

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31

Wehder, Liane [Verfasser], Ferdinand von [Akademischer Betreuer] Eggeling, Stephan [Akademischer Betreuer] Diekmann, and Jens [Akademischer Betreuer] Habermann. "Molekulares Imaging (MALDI-IMS) humaner Kopf-Hals-Tumore und funktionelle Analyse pathologisch exprimierter Proteine am Beispiel von S100A8 und Annexin A5 / Liane Wehder. Gutachter: Ferdinand von Eggeling ; Stephan Diekmann ; Jens Habermann." Jena : Thüringer Universitäts- und Landesbibliothek Jena, 2014. http://d-nb.info/1046563386/34.

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32

Goyette, Jesse Davis Medical Sciences Faculty of Medicine UNSW. "The extracellular functions of S100A12." Publisher:University of New South Wales. Medical Sciences, 2008. http://handle.unsw.edu.au/1959.4/41302.

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The S100s comprise a group of Ca2+-binding proteins of the EF-hand superfamily with varied functions. Within this family, three inflammatory-related proteins - S100A8, S100A9 and S100A12 - form a subcluster known as the 'calgranulins'. S100A12 levels are elevated in sera from patients with inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease. S100A12 is constitutively expressed in neutrophils and induced in monocytes by LPS and TNFα, and in macrophages by IL-6. S100A12 is a potent monocyte and mast cell chemoattractant and its potentiation of mast cell activation

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Mossel, Dieuwertje M. [Verfasser], and Julia [Akademischer Betreuer] Kzhyshkowska. "Epigenetic regulation of S100A9 and S100A12 expression in monocytes-macrophage system in hyperglycemic conditions / Dieuwertje Marije Mossel ; Betreuer: Julia Kzhyshkowska." Heidelberg : Universitätsbibliothek Heidelberg, 2020. http://d-nb.info/1219303100/34.

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34

Mossel, Dieuwertje Marije [Verfasser], and Julia [Akademischer Betreuer] Kzhyshkowska. "Epigenetic regulation of S100A9 and S100A12 expression in monocytes-macrophage system in hyperglycemic conditions / Dieuwertje Marije Mossel ; Betreuer: Julia Kzhyshkowska." Heidelberg : Universitätsbibliothek Heidelberg, 2020. http://d-nb.info/1219303100/34.

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35

Turnier, Jessica L. M. D. "Urine S100 Proteins as Potential Biomarkers of Lupus Nephritis Activity." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1491308278173071.

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Zwicker, Stephanie [Verfasser], and Ronald [Akademischer Betreuer] Wolf. "Psoriasin (S100A7) and koebnerisin (S100A15) in the model of inflammation : functional characterization in the inflammation cascade / Stephanie Zwicker. Betreuer: Ronald Wolf." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2014. http://d-nb.info/1075456991/34.

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37

Herwig, Nadine. "Der RAGE-Ligand S100A4." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-214035.

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Das maligne Melanom zählt zu den aggressivsten und behandlungsresistentesten aller Krebsarten. In den letzten 20 Jahren hat sich die Rate der Melanom-Erkrankungen innerhalb der weißen Bevölkerung verdreifacht. Mittlerweile liegen eine Reihe von Untersuchungen zu den molekularbiologischen Mechanismen der Entwicklung und Progression des malignen Melanoms vor. Aktuelle Forschungsvorhaben beschäftigen sich vor allem mit der Identifizierung Melanom-spezifischer Biomarker, die diagnostische und prognostische Informationen liefern sowie die Entwicklung einer zielgerichteten, kombinierten und indivi

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McNeill, Eileen. "Neutrophil function in S100A9 null mice." Thesis, University College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.423552.

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39

Raponi, Eric. "L'expression séquentielle des calciprotéines S100A1 et S100B dans les cellules gliales du système nerveux central caractérise différents stades développementaux en relation avec leurs potentialités de différenciation." Université Joseph Fourier (Grenoble), 2005. https://tel.archives-ouvertes.fr/tel-00178904.

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Les précurseurs neuraux adultes possèdent une plasticité cellulaire suggérant un role dans l'apparition de pathologies mais aussi un potentiel curratif inespéré. Cependant, l'emploi clinique de ces cellules nécessite une connaissance des mécanismes biologiques contrôlant leur prolifération, maturation ou spécification cellulaire. Dans cette thèse nous avons étudié l'expression des protéines 8100 A1 et B dans les cellules progénitrices d'oligodendrocytes (OPC) et les cellules souches astrocytaires. Nous avons démontré que 1) toutes les cellules gliales expriment précocement la 8100A1 alors que

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Nogueira, Thiago de Oliveira. "Efeito antinociceptivo induzido pelo glicogênio em ratos submetidos ao modelo de pressão de pata: relação com a migração neutrofílica e a expressão da proteína S100A9." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/10/10133/tde-08102012-151355/.

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A peritonite neutrofílica induzida por glicogênio acarreta antinocicepção em camundongos submetidos ao teste de contorção abdominal, a qual é mediada por uma proteína ligante de cálcio, com peso molecular de 14 kDa, denominada S100A9. O objetivo do presente trabalho foi aprofundar o estudo sobre o envolvimento dos neutrófilos na antinocicepção induzida pelo glicogênio em ratos submetidos ao teste de pressão de pata e avaliar a expressão da proteína S100A9 nos tempos onde foi detectado esse efeito. O glicogênio induz antinocicepção em ratos entre 2 e 12 horas após sua injeção intraplantar. O p

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Liu, Yidong. "Design, synthesis and evaluation of S100A4 protein inhibitors." Thesis, University of Nottingham, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.738338.

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S100A4 is a 101-amino acid protein belong to a largest sub group of EF-hand calcium binding proteins, and has been described as having both intracellular and extracellular functions. Human S100A4 is the best characterized member of the S100 protein family in terms of its role in cancer and metastasis formation. Overexpression of S100A4 has been observed in several metastatic cancers. It is recognized that an increased level of S100A4 expression correlates with a high incidence of metastasis and poor prognosis for cancer patients. Therefore S100A4 is regarded as a practical target for cancer tr

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Sack, Ulrike. "New insights into S100A4-induced colon cancer metastasis." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2011. http://dx.doi.org/10.18452/16313.

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S100A4 spielt eine zentrale Rolle für die Metastasierung des Dickdarmkrebses. Die Hemmung der S100A4 Expression stellt damit einen vielversprechenden therapeutischen Ansatz dar. Die vorliegende Arbeit präsentiert Niklosamid und Calcimycin als neue Inhibitoren der S100A4 Transkription. In Kolonkarzinomzellen, die mit einem der beiden Inhibitoren behandelt wurden, wurde die S100A4 Expression konzentrations- und zeitabhängig unterdrückt. Des Weiteren war die Zellmigration und -invasion in Abhängigkeit von S100A4 in behandelten Zellen vermindert. Niklosamid und Calcimycin Behandlung verhinderten

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Jervis, T. J. "Crystallisation and structural studies of bifunctional enzyme and S100A4." Thesis, Keele University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267460.

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Melo, Bruno Marcel Silva de. "Alarmina S100A9: um mediador crítico no desenvolvimento da psoríase." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/17/17147/tde-06042018-094810/.

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A psoríase (Ps) é uma doença inflamatória crônica-imunomediada da pele, caracterizada por proliferação acentuada e diferenciação anormal de queratinócitos e aumento do infiltrado de células inflamatórias na derme. S100A9 é um alarmina que é produzida por queratinócitos e células mielóides em condições inflamatórias. No entanto, o papel desta molécula no desenvolvimento e manutenção da resposta inflamatória da Ps permanece desconhecida. Nesso objeitvo foi investigar o papel de S100A9 no desenvolvimento da psoríase. Análises de bioinformática de um banco de dados disponível on-line contendo valo

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Otterbein, Ludovic R. "Etudes cristallographiques de l'actine et de la S100A6 humaine." Aix-Marseille 1, 2002. http://www.theses.fr/2002AIX11018.

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Dans la cellule eucaryote, l'actine est une protéine impliquée dans de nombreuses fonctions biologiques où elle joue un rôle dans la mobilité, la modification de l'aspect des cellules et dans la contraction musculaire. Nous avons déterminé la structure cristallographique de l'actine monomérique sous forme ADP à la résolution de 1,54 Å. Cette structure montre des changements conformationnels de la protéine lors de la libération du Pi du site catalytique. De plus, l'utilisation de la tétraméthylrhodamine-5-maléimide pour bloquer la polymérisation de l'actine permet dorénavant d'envisager la co-c

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Moraes, Natassja Foizer. "O C-terminal da proteína S100A9 murina modula os eventos envolvidos na angiogênese e na progressão tumoral em modelos in vitro." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/10/10133/tde-09122015-114330/.

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As proteínas S100A8/A9 são expressas em diferentes tipos celulares e quando sozinhas ou complexadas e em baixas concentrações, promoveram proliferação, migração celular e formação de estruturas capilares. Por outro lado, quando em altas concentrações, esse complexo inibe o crescimento de diversos tipos de células tumorais murinas e humanas. Ainda, tanto a proteína S100A9 humana, quanto um peptídeo sintético idêntico a porção C-terminal da proteína S100A9 murina (pS100A9m) possuem efeitos antinociceptivo e imunorregulatório. Apesar dessas evidencias, até o momento não foi investigado o efeito d

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Deol, Yadwinder S. "ROLE OF PSORIASIN (S100A7) IN ESTROGEN RECEPTOR POSITIVE BREAST CANCERS." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1338359283.

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Pietas, Agnieszka. "Identification of the tumour-associated gene S100A14 and analysis of its regulation." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2005. http://dx.doi.org/10.18452/15196.

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Durch Analyse der Subtraktion-cDNA Bibliothek einer humanen Lungentumor Zelllinie haben wir ein neues Mitglied der S100 Genfamilie identifiziert und charakterisiert, welches S100A14 benannt wurde. Die vollständige cDNA hat eine Länge von 1067 bp und kodiert für ein Protein von 104 Aminosäuren, welches die S100-spezifische Kalzium-bindende Domäne enthält. Das Gen wird in normalen humanen Epithelien ubiquitär exprimiert, zeigt jedoch Expressionsverluste in vielen Tumorzelllinien. Im Gegensatz zu Tumorzelllinien ist S100A14 auf mRNA- und Proteinebene in vielen humanen Primärtumoren stärker exprim

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Moroz, Olga. "Structural studies on human S100A12." Thesis, University of York, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403963.

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Hoffmann, Roman, and Sebastian Uljas Lutz. "The health knowledge mechanism: evidence on the link between education and health lifestyle in the Philippines." Springer, 2018. http://dx.doi.org/10.1007/s10198-017-0950-2.

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Studies have found substantial differences in health-related behavior and health care usage between educational groups, which may explain part of the well-documented educational gradient in health. The allocative efficiency hypothesis offers a behavioral explanation for these reported differences. According to this theory, the educated possess more health knowledge and information, allowing them to make better health choices. We perform a mediation analysis to study this mechanism using original survey data from the Philippines, a lower-middle-income country. As an extension of previous empiri

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