Relevant bibliographies by topics / Saccharin

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Saccharin'

Author: Grafiati
Published: 4 June 2021
Last updated: 16 June 2025

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Journal articles on the topic "Saccharin"

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Lee, Chang Hee, Won Yun, Ji Hwan Lee, et al. "Effects of artificial sweeteners on feed palatability and performance in weaned pigs." Canadian Journal of Animal Science 99, no. 2 (2019): 307–14. http://dx.doi.org/10.1139/cjas-2018-0143.

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In experiment 1, a total of 30 weaning pigs were allotted to three dietary treatments to check the palatability of the dietary feed. Diet treatments were as follows: reference diets = basal diets + 0.05% saccharin (50% Saccharin-natrium), TRT1 = 0.03% saccharin–neotame mix (50% Saccharine-natrium + 2% Neotame), TRT2 = 0.02% neotame (10% Neotame), and TRT3 = 0.02% saccharin–neotame mix (10% Saccharine-natrium + 10% Neotame). TRT2 group was significantly higher than other treatments in palatability (P < 0.05). In experiment 2, a total of 52 weaning pigs were allotted to four dietary treatments. In the average daily gain and average daily feed intake over 1 wk, the TRT2 group was significantly higher than the TRT1 and TRT3 groups (P < 0.05). The concentration of triglyceride in the blood was highest in the TRT1 treated group and the lowest in the TRT2 group (P < 0.05). The Lactobacillus was significantly higher in the TRT2 and TRT3 treatments compared with 0.05% saccharin (50% Saccharine-natrium) (P < 0.05). There was no significant difference in the number of Escherichia coli (P < 0.05). In conclusion, diets supplemented with neotame could improve palatability, and artificial sweeteners can affect nutrient digestibility, blood characteristic, and fecal microbiota.
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Mahmood, Ammar A. Razzak, and Sahar B. Al-Juboori. "A Review: Saccharin Discovery, Synthesis, and Applications." Ibn AL- Haitham Journal For Pure and Applied Sciences 33, no. 2 (2020): 43. http://dx.doi.org/10.30526/33.2.2442.

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Saccharin is firstly synthesized in 1879. It is a very well-known as an inexpensive substitute for sugar as it is a non-caloric sweetener. The article shows the properties, use, metabolism and various synthesis and reactions of saccharine. Moreover, the toxicological reports explain that saccharin is mostly responsible for the bladder tumors observed in the male rats, the relationship between the consumption of saccharin and bladder cancer is afforded by epidemiological studies. The benefit-risk evaluation for saccharin is hardly to indicate. Saccharin is a sugar substitute, frequently used either in food industry, or in pharmaceutical formulations and even in tobacco products. The chemistry of saccharin is interesting because of it suspected carcinogenous character and the possible use as an antidote for metal poisoning. It appears prudent to evaluate their main properties and applications further.
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Kumar Das, Malay, Ruru Hao, Ekachai Srikaen, et al. "Effect of Saccharin Sodium on the Microstructure and Hardness of Electrodeposited Ni-W Coatings." Key Engineering Materials 659 (August 2015): 535–39. http://dx.doi.org/10.4028/www.scientific.net/kem.659.535.

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Nickel-tungsten alloy were fabricated by electrodeposition on carbon steel. The influences of saccharin sodium on the coatings were analyzed using XRD, SEM, and hardness tester. This study reveals that the presence of saccharine sodium has a profound impact on the morphology of the coatings. Moreover, the addition of saccharine sodium tends to enhance the tungsten content in the coatings along with hardness and the grain size of the deposits.
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Miller, S. A., and V. P. Frattali. "Saccharin." Diabetes Care 12, no. 1 (1989): 74–80. http://dx.doi.org/10.2337/diacare.12.1.74.

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Miller, S. A., and V. P. Frattali. "Saccharin." Diabetes Care 12, no. 1 (1989): 75–80. http://dx.doi.org/10.2337/diacare.12.1.75.

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Shahnavaz, Zohreh, Lia Zaharani, Mohd Rafie Johan, and Nader Ghaffari Khaligh. "A Green Alternative for Aryl Iodide Preparation from Aromatic Amines." Current Organic Synthesis 17, no. 2 (2020): 131–35. http://dx.doi.org/10.2174/1570179417666200203121437.

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Background: In continuation of our previous work and the applications of saccharin, we encouraged to investigate the one-pot synthesis of the aryl iodides by the diazotization of the arene diazonium saccharin salts. Objective: Arene diazonium salts play an important role in organic synthesis as intermediate and a wide variety of aromatic compounds have been prepared using them. A serious drawback of arene diazonium salts is their instability in a dry state; therefore, they must be stored and handled carefully to avoid spontaneous explosion and other hazard events. Methods: The arene diazonium saccharin salts were prepared as active intermediates in situ through the reaction of various aryl amines with tert-butyl nitrite (TBN) in the presence of saccharin (Sac–H). Then, in situ obtained intermediates were used into the diazotization step without separation and purification in the current protocol. Results: A variety of aryl iodides were synthesized at a greener and low-cost method in the presence of TBN, Sac–H, glacial acetic acid, and TEAI. Conclusion: In summary, a telescopic reaction is developed for the synthesis of aryl iodides. The current methodology is safe, cost-effective, broad substrate scope, and metal-free. All used reagents are commercially available and inert to moisture and air. Also, the saccharine and tetraethylammonium cation could be partially recovered from the reaction residue, which reduces waste generation, energy consumption, raw material, and waste disposal costs.
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Morkūnaitė, Vaida, Lina Baranauskienė, Asta Zubrienė, et al. "Saccharin Sulfonamides as Inhibitors of Carbonic Anhydrases I, II, VII, XII, and XIII." BioMed Research International 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/638902.

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A series of modified saccharin sulfonamides have been designed as carbonic anhydrase (CA) inhibitors and synthesized. Their binding to CA isoforms I, II, VII, XII, and XIII was measured by the fluorescent thermal shift assay (FTSA) and isothermal titration calorimetry (ITC). Saccharin bound the CAs weakly, exhibiting the affinities of 1–10 mM for four CAs except CA I where binding could not be detected. Several sulfonamide-bearing saccharines exhibited strong affinities of 1–10 nM towards particular CA isoforms. The functional group binding Gibbs free energy additivity maps are presented which may provide insights into the design of compounds with increased affinity towards selected CAs.
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Bhanage, Bhalchandra, Sujit Chavan, and Adithyaraj K. "In situ Generation and Utilization of CO: An Efficient Route towards N-Substituted Saccharin via Carbonylative Cyclization of 2-Iodosulfonamides." Synlett 28, no. 15 (2017): 2000–2003. http://dx.doi.org/10.1055/s-0036-1588422.

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The present protocol demonstrates the synthesis of N-substituted saccharines via carbonylative cyclization of 2-iodosulfonamides using a Pd(OAc)2/Xantphos catalyst system and phenyl formate as a CO source. A variety of saccharin derivatives is synthesized under milder reaction conditions.
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Marcus, Alan I. "Sweets for the Sweet: Saccharin, Knowledge, and the Contemporary Regulatory Nexus." Journal of Policy History 9, no. 1 (1997): 33–47. http://dx.doi.org/10.1017/s0898030600005819.

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In 1977, the United States Congress forbade the Food and Drug Administration to outlaw use of the food additive saccharin as an artificial sweetener for a period of three years. Subsequent legislation extended the congressional ban. It remains in effect today. Congress's saccharin action neatly represented late twentieth-century federal regulatory policy. The process had become decidedly antibureaucratic and ultimately democratic. Forces both for saccharin's prohibition and for its continued use outlined and debated their positions in public, letting their arguments contend in the marketplace of ideas. Following the conduct of this de facto national plebiscite, duly elected representatives weighed the respective cases and selected the course that their constituents seemed to favor.
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Sutomo, Artono Dwijo, Pratiwi Kusumawardhani, Hana Hanifah Yasmin, et al. "Saccharin Dependence of Magnetoimpedance Ratio in Electrodeposited Permalloy Multilayer Structure on Meandered-Copper Printed-Circuit-Board Substrates." Trends in Sciences 20, no. 11 (2023): 6695. http://dx.doi.org/10.48048/tis.2023.6695.

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The effect of saccharin concentration on magnetoimpedance ratio in multilayer permalloy structure i.e., [NiFe/Cu/NiFe]3/Cu/[NiFe/Cu/NiFe]3 on Cu printed circuit board (PCB) meander substrates have been discussed. The multilayer [NiFe/Cu/NiFe]3/Cu/[NiFe/Cu/NiFe]3 structure was prepared by using the electrodeposition method. The results of XRF characterization show that the composition of Ni:Fe is close to the calculation mol ratio permalloy of 80:20. The magnetoimpedance effect is evaluated by total impedance measurement at the various magnetic fields. The typical increase of the magneto-impedance ratio with frequency confirms in this experiment. Here, the magnetoimpedance ratio modifies from 0.07 to 1.63 % for frequency measurements of 20 and 100 kHz, respectively. Finally, the MI ratio monotonically decreases with an increase in additive saccharin concentration. The MI ratio slightly decreases by 17.17 % (=(1.63-1.35)/1.63) for additive saccharin concentration increase of 1 to 2 g/L. Then MI ratio drastically decreases by 40.0 % (=(1.35-0.81)/1.35) in the change of additive saccharin concentration from 2 to 4 g/L. Here, the change in the morphological surface should attribute to the decrease in the MI ratio. HIGHLIGHTS Multilayer [NiFe/Cu/NiFe]3/Cu/[NiFe/Cu/NiFe]3 structure on Cu PCB meander substrates has been successfully fabricated by electrodeposition procedure. The magneto-impedance effect of the multilayer samples has been successfully showed at low frequency of ~kHz order. The saccharine as an additive material for electrodeposition procedure can modify the magneto-impedance effect of the multilayer sample. GRAPHICAL ABSTRACT
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Dissertations / Theses on the topic "Saccharin"

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Joshi, Onkar D. "Development of a solvent free continuous co-crystallisation technique for carbamazepine ¿ saccharin." Thesis, University of Bradford, 2012. http://hdl.handle.net/10454/5697.

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Co-crystals are emerging as a potential area in the field of crystal designing as it improves material¿s physicochemical properties. Many groups are working on the development of newer techniques for the preparation of co-crystals, which can be scalable and contribute to the green agenda. Being continuous and scalable technique, our own developed twin screw extrusion mediated solvent free continuous co-crystallisation (SFCC) technique has been used for the preparation of carbamazepine: saccharin co-crystal. Carbamazepine has been used as a model drug since it shows challenges such as low solubility (BCS class II), polymorphism and thermolabile nature whilst, saccharin was used as a co-former. Effect of extrusion processing parameters such as shear, temperature and screw speed on cocrystallisation has been studied. In addition to this, effect of particle size of co-crystal components, use of hydrated form of carbamazepine, addition of solvent and application of reverse elements on the purity of co-crystal was understood. Use of carbamazepine dihydrate as a starting component yields pure co-crystals. The addition of small amount of polar solvent in anhydrous carbamazepine also yields pure co-crystals whereas particle size did not show any significant effect. Result showed that selection of processing temperature near to eutectic, moderate shear and increase in residence time of component mixture in mixing zone was mainly responsible for co-crystallisation. The extrudates were mainly characterised by XRPD, DSC and in-vitro dissolution tests. Pure co-crystals prepared by addition of highly Development of a solvent free continuous co-crystallisation technique for carbamazepine-saccharin ii polar solvent have been showed drug release identical to that of pure co-crystals prepared by solvent crystallisation.
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Heaton, G. D. "The effects of high dietary levels of saccharin on in vivo and in vitro drug metabolism." Thesis, University of Southampton, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233722.

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Lawrie, Charles Alexander. "The effects of saccharin on the metabolism of amino acids by the gut flora." Thesis, University of Southampton, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316353.

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Augier, Eric. "Résilience et vulnérabilité à l'addiction chez le rat : rôle révélateur du choix." Thesis, Bordeaux 2, 2011. http://www.theses.fr/2011BOR21845/document.

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L’addiction à la cocaïne, aussi appelée dépendance (APA 1994), est un trouble chronique associé à un risque élevé de rechute. Ce trouble touche une fraction significative des consommateurs de cocaïne (environ 15%) et est caractérisé par (1) une compulsion de la recherche et de la prise de cocaïne, (2) une perte de la capacité de contrôler sa consommation et (3) l’émergence d’un état émotionnel négatif (par exemple anxiété, irritabilité) lorsque le sujet dépendant est sevré. Le plus surprenant dans l’addiction est que les sujets atteints semblent agir contre leur propre intérêt, et ce malgré la conscience des conséquences néfastes de leur comportement. Un des grands enjeux actuels de la recherche sur l’addiction est de comprendre les mécanismes neurobiologiques expliquant le passage d’une consommation de drogue occasionnelle, récréative à une consommation compulsive et incontrôlée.Devant les limitations inhérentes aux études neurobiologiques chez l’homme (impossibilité d’utiliser des techniques invasives, méthodes employées corrélationnelles), ces études sont souvent complémentées par des études parallèles sur des modèles animaux de prise de drogue et d’addiction. Bien qu’ayant permis des découvertes importantes sur la neurobiologie de la cocaïne (comme par exemple l’implication du système dopaminergique dans les propriétés renforçantes de la cocaïne), la validité de ces modèles reste toutefois incertaine, en particulier à cause de l’absence de choix pendant l’accès aux drogues. Dans ces conditions, il est difficile de savoir si les animaux consomment de la drogue par compulsion ou bien par défaut d’autres choix.Afin d’étudier ce problème, nous avons développé dans notre équipe en 2007 un nouveau modèle dans lequel des rats ont le choix de prendre de la cocaïne ou de s’engager dans une autre activité récompensante (par exemple boire de l’eau sucrée avec de la saccharine). Il a ainsi pu être montré que la vaste majorité des animaux se détournaient de la drogue au profit de la récompense alternative. Mon travail de thèse a consisté à confirmer et tester la généralité et la robustesse de cette découverte surprenante. J’ai ainsi pu montrer que la cocaïne occupait une faible place sur l’échelle de valeur du rat, au niveau des concentrations les plus faibles d’eau sucrée. J’ai également pu établir que la préférence des animaux pour l’eau sucrée ne peut être expliquée ni par l’existence de propriétés anxiogènes de la cocaïne, ni par l’attrait pour la nouveauté du goût sucré et, enfin, ni par l’impossibilité de l’animal de contrôler son degré d’intoxication à la drogue. Enfin, de manière importante, j’ai pu constater que seule une minorité d’individus, n’excédant pas 15 % au niveau le plus sévère d’exposition à la drogue, continue à prendre de la cocaïne malgré le choix, même lorsqu’ils sont en privation alimentaire et qu’ils ont la possibilité de choisir un sucre naturel qui pourrait combler leur besoin en calories.L’ensemble de ces résultats pourrait alors signifier que, comme chez l’être humain, l’addiction à la cocaïne ne touche qu’une fraction minoritaire d’individus, la large majorité restante étant résiliente à l’addiction (c’est-à-dire résistante quelque soit le degré d’exposition à la cocaïne). Le modèle de choix pourrait donc servir à révéler et à sélectionner objectivement et efficacement les individus vulnérables face à l’addiction. Les nombreuses applications de cette méthode de sélection par le choix sont discutés à la fin de ma thèse<br>Drug addiction is defined as compulsive drug use that is, excessive and difficult to control despite negative consequences. A critical problem in current addiction research is to understand the transition between controlled and compulsive drug use. In standard drug self-administration settings, animals have no choice than drug use. As a result, serious doubt exists about the interpretation of drug use in experimental animals. Is it symptomatic of an underlying addiction state or merely an expectable response to lack of choice? This incertitude in turn casts a shadow over many behavioral and neurobiological changes that have been well documented in animals following extended drug self-administration. Do they reflect pathological dysfunctions or normal neurobiological adaptations?To address this issue, we have recently developed in our lab a rat model of the transition to cocaine addiction was recently developed and partially validated. Overall, available evidence shows that when a valuable behavioral option, even a biologically or physiologically inessential one, is made available during access to cocaine self-administration, most rats readily abstain from cocaine use in favor of the alternative reward regardless of the amount of past cocaine use. The goal of my thesis was to continue the validation of this model. My main results demonstrate that cocaine is very low on the value ladder of rats, and that this can't be explained away neither by the anxiogenic properties of cocaine, neither by saccharin habituation or satiation nor by the impossibility of the animals to control their cocaine intoxication. Overall, only a small minority of rats continue to self-administer the drug despite the opportunity of making a different choice. This pattern of results (i.e., abstinence in most rats; cocaine preference in few rats) maps well onto what is currently known about the epidemiology of human cocaine addiction. It is thus possible that the minority of cocaine-preferring rats would be homologous to the minority of human cocaine users with a diagnosis of addiction while the remaining majority of abstinent rats would be resilient to cocaine addiction. Choice could represent an objective method of selection of addicted animals for future research on the neurobiological dysfunctions that are hypothesized to underlie cocaine addiction. Other competing interpretations of the same pattern of results are also discussed at the end of this thesis
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Leiding, Mara Lee. "Rates of Ethanol Intake Resulting from Restricted and Free Access to Sodium Saccharin and Glucose in Sprague Dawley Rats." W&M ScholarWorks, 1994. https://scholarworks.wm.edu/etd/1539625932.

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Duarte, Marcella Omena de Oliveira 1984. "Aspectos fisiológicos e na expressão de proteínas da via de sinalização da insulina diante a adição de sacarose e edulcorantes na dieta de ratos wistar." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311372.

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Orientador: Nelci Fenalti Höehr<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-19T02:59:05Z (GMT). No. of bitstreams: 1 Duarte_MarcellaOmenadeOliveira_M.pdf: 1239210 bytes, checksum: 7fe6d12625990e91b719a6a57de600c9 (MD5) Previous issue date: 2011<br>Resumo: A obesidade é uma doença crônica, multifacetada e de genética complexa que, associada às suas co-morbidades, conduz a um aumento no risco de mortalidade. Essa patologia provém do balanço energético positivo entre a ingestão e gasto calórico, e é um dos principais componentes da síndrome metabólica. A preocupação com a incidência dessa doença influenciou o consumo de produtos com adição de adoçantes que, sem a devida orientação nutricional, podem não suprir adequadamente as necessidades energéticas e, ao invés de prevenir ou regredir a obesidade, podem contribuir para o aparecimento da mesma. Explorando a hipótese de que a resistência à ação central da insulina pode ser o elo entre a obesidade e demais condições clínicas, este estudo investiga os efeitos da adição, na dieta de ratos, da sacarose e dos edulcorantes: ciclamato e sacarina, na via de sinalização hipotalâmica da insulina, e sua possível influência em aspectos fisiológicos, tais como volume de ingestão, ganho de peso, taxa de desaparecimento da insulina (Kitt) e peso do tecido adiposo epididimal; bem como em aspectos moleculares, verificando a expressão de proteínas da via de sinalização de insulina, tais como IR, IRS 1 e Akt. Foram analisados dados obtidos a partir do tratamento de ratos Wistar machos divididos em quatro grupos, tendo sido cada grupo submetido, por quarenta dias, a uma das seguintes dietas: somente ração (controle), ração com adição de sacarose em solução aquosa a 30%, ração com adição de sacarina associada a ciclamato de sódio em solução aquosa a 30%, e ração com adição de sacarina em solução aquosa a 30%. Para avaliação da ingestão espontânea em doze horas, os animais foram submetidos à estereotaxia do ventrículo cerebral para possibilitar a injeção, de forma aguda, de insulina em quantidades pré-determinadas. O estudo mostrou que os animais submetidos às dietas estudadas apresentaram maior ganho de peso e no volume de ingestão e uma redução na sensibilidade à ação periférica da insulina em relação ao grupo tratado com sacarose. Também se verificou que os grupos tratados com dietas acrescidas de edulcorantes tiveram uma expressão reduzida das proteínas da via de sinalização da insulina, quando comparados ao grupo controle, indicando um risco aumentado de desenvolvimento de resistência central à ação da insulina nesses animais. Assim, concluímos que a adição desses edulcorantes à dieta de ratos supõe-se refletir em menor ação do hormônio, nesses animais, em tecidos periféricos<br>Abstract: Obesity is a chronic, multifaceted and genetically complex disease which, associated to its co-morbidities, leads to an increased risk of mortality. This disease is a major component of the Metabolic Syndrome and comes from the positive energy balance between caloric intake and expenditure. Concern about the incidence of this disease influenced the consumption of products with the addition of sweeteners that, without proper nutritional guidance, may not adequately supply the energy needs and, instead of preventing or reversing the obesity, may contribute to the appearance of the same. Exploring the hypothesis that Resistance to Insulin may be the link between obesity and other medical conditions, this study investigates the effects of the addition, in the diet of rats, of sucrose and the sweeteners: cyclamate and saccharin, on the signaling pathway of hypothalamic insulin, and also its effects on physiological aspects, such as intake volume, weight gain, insulin decay rate (Kitt) and epididymal adipose tissue weight; as well as on molecular aspects, verifying the expression of proteins related to the insulin signaling pathway, such as IR, IRS 1 and Akt. We analyzed data obtained from the treatment of male Wistar rats divided into four groups, each group having been subjected for forty days of one of the following diets: ration only (control group), ration with addition of sucrose in aqueous solution at 30%, ration with addition of associated saccharin and sodium cyclamate in aqueous solution at 30%, and ration with the addition of saccharin in aqueous solution at 30%. To assess the spontaneous intake volume in twelve hours, animals underwent cannulation of the cerebral ventricle to enable the injection, acutely, of insulin in predetermined amounts. The study indicated that animals fed with the diets studied showed greater weight gains, higher intake volume and a reduction in peripheral sensitivity to insulin action compared to the group treated with sucrose. We also found that groups treated with ration containing sweeteners had a reduced expression of proteins of the insulin signaling pathway when compared to the control group, indicating an increased risk of developing resistance to the central action of insulin in these animals.Thus, we conclude that the addition of sweeteners to the diet of rats it is assumed to reflect on a reduced action of this hormone in the peripheral tissues of these animals<br>Mestrado<br>Ciencias Biomedicas<br>Mestre em Ciências Médicas
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Kasten, Chelsea Rae. "Intra-nucleus accumbens shell injections of R(+)- and S(-)- baclofen bidirectionally alter binge-like ethanol, but not saccharin, intake in C57Bl/6J mice." Thesis, Behavioural Brain Research (Elsevier), 2014. http://hdl.handle.net/1805/6453.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>It has been proposed that the GABAB receptor subtype plays a role in alcoholism and alcohol use disorders (AUDs) (Cousins et al., 2002; Agabio et al., 2012). Specifically, the GABAB agonist baclofen has been looked at extensively in clinical and pre-clinical studies. In various animal models of chronic and intermittent consumption, baclofen has been shown to both increase (Petry, 1997; Smith et al., 1999; Czachowski et al., 2006; Moore et al., 2007) and decrease (Colombo et al., 2000; 2002; 2005; Stromberg, 2004; Moore et al., 2009) drinking. A critical issue in determining pharmacological effects of a drug is using the appropriate animal model. The drinking-in-the-dark (DID) model, developed by Rhodes et al. (2005, 2007), produces high levels of drinking in a binge-like paradigm and has been used to assess many pharmacological targets (e.g. Kamdar et al., 2007; Gupta et al., 2008; Moore et al., 2007; 2009). While DID produces high-levels of binge drinking, it is unclear what areas of the brain are involved in this behavior. A direct way to target areas that are believed to be involved in the circuitry of particular behaviors is through microinjection of drugs (Kiianmaa et al., 2003). Of particular recent interest involving motivated behaviors and addiction is the nucleus accumbens (Acb) (Everitt & Robbins, 2005); specifically the accumbens shell (AcbSh) (e.g. Rewal et al., 2009, 2012; Nie et al., 2011; Leriche et al., 2008). The current study aimed to investigate the role of GABAB receptors in the AcbSh by examining the ability of two different enantiomers of baclofen to alter ethanol and saccharin intake in male C57BL/6J (B6) mice. B6 mice underwent bilateral cannulation surgery targeting the AcbSh. After 48 hours of recovery time, animals began a five day Drinking-in-the-Dark (DID) procedure where they received 20% ethanol or 0.2% saccharin for two hours, three hours into the dark cycle, each day. Throughout the five drinking sessions, animals were kept in home-cage locomotor activity chambers to monitor activity throughout the drinking cycle. Day 4 drinking was immediately preceded by a mock microinjection, whereas Day 5 drinking was immediately preceded by a drug microinjection. Microinjection of one of five doses of baclofen was given in ng/side dissolved in 200 µl of aCSF (aCSF alone, 0.02 R(+)-, 0.04 R(+)-, 0.08 S(-)-, or 0,16 S(-)-). Intake was recorded every twenty minutes on Days 4 and 5. Retro-orbital sinus blood samples were taken from ethanol animals immediately following the Day 5 drinking period to determine blood ethanol concentrations (BECs). A one-way ANOVA on total Day 4 ethanol consumption revealed no baseline differences between dose groups. A one-way ANOVA on total Day 5 ethanol consumption revealed that the 0.04 R(+)- baclofen dose reduced total drinking, but the 0.16 S(-)- baclofen dose increased total drinking (p’s<0.05). This pattern was reflected in the BECs; 0.04 R(+)- baclofen reduced BECs, whereas 0.16 S(-)- baclofen increased BECs (p’s<0.05). These results were also time-dependent, with R(+)-baclofen reducing drinking in the first 20 minutes of the session and S(-)- increasing drinking in the last 40 minutes of the session. There were no effects on saccharin intake. An issue with the locomotor activity boxes led to unreliable locomotor activity counts. However, because there were no drug effects on saccharin consumption, it was concluded that locomotor effects did not contribute to the decreases or increases in ethanol consumption. These results further implicate the role of GABAB receptors in modulating ethanol intake. The bidirectional effects shown highlight the importance of considering enantioselective drug effects when interpreting data. Finally, these results also support previous conclusions that the AcbSh plays an important role in modulating use of drugs of abuse, but not other reinforcers.
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Goodwin, Frances L. W. "Do taste factors contribute to the mediation of voluntary ethanol consumption an investigation of ethanol and saccharin-quinine intake in non-selected laboratory rats /." Thesis, Connect to online version, 1995. http://wwwlib.umi.com/cr/concordia/fullcit?pMM05100.

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Proença, Mahara-Daian Garcia Lemes [UNESP]. "Transporte mucociliar e atividade física na vida diária de fumantes saudáveis." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/87330.

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Made available in DSpace on 2014-06-11T19:22:50Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-11-26Bitstream added on 2014-06-13T20:09:55Z : No. of bitstreams: 1 proenca_mdgl_me_prud.pdf: 275116 bytes, checksum: 41234546e4bf8949f8d0df066c0a89d6 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Fundação para o Desenvolvimento da UNESP (FUNDUNESP)<br>A eficiência do transporte mucociliar pode variar em diferentes condições, como na exposição a partículas nocivas da fumaça do cigarro. O presente estudo avaliou os efeitos do cigarro, tanto imediato quanto a curto prazo, no transporte mucociliar nasal de fumantes por meio da quantificação do tempo de trânsito da sacarina (TTS), e os correlacionou com a intensidade de consumo tabagístico. Métodos: Dezenove fumantes ativos (11 homens; 51±16 anos; IMC 23±9 kg/m2; 27±11 cigarros/dia; 44±25 anos/maço), participantes de programa de intervenção antitabagismo, responderam a um questionário referente ao histórico tabagístico e foram submetidos à avaliação da função pulmonar (espirometria) e transporte mucociliar (pelo TTS), este imediatamente e após 8 horas do ato de fumar. Para comparação, um grupo pareado composto por 19 indivíduos saudáveis não-fumantes foi avaliado por meio dos mesmos testes. Resultados: Quando comparados ao TTS de não-fumantes (10±4 min; média±desvio padrão), os fumantes apresentaram tempo de transporte similar imediatamente após fumar (11±6 min; p=0,87) e significativamente mais lento 8 horas após fumar (16±6 min; p=0,005 versus não-fumantes e p=0,003 versus fumantes). Em fumantes...<br>The mucociliary system is influenced by different conditions such as physical exercise and exposure to cigarette smoke, although the relationship between mucociliary function and the level of physical activity in daily life (PADL) in healthy smokers is unknown. Objectives: To investigate the relationship between mucociliary transport and daily physical activity in smokers. Methods: Fifty two current smokers were submitted to assessment of mucociliary transport (Sacharin Transit Time, STT), carbon monoxide levels in the exhaled air, lung function (spirometry) and smoking history. Furthermore, subjects remained for six days with a waist-worn pedometer in order to determine their level of PADL (steps/day). The tests were also performed in 30 matched healthy nonsmokers who served as control group. Results: Light smokers (≤15 cigarettes/day) had a STT of 9 (6-11) min (median [interquartile range]), which was similar to nonsmokers (8 [5-14]min; p=0.8). Both moderate (16-25 cigarettes/day) and heavy (>25 cigarettes/day) smokers had significantly higher STT (12 [9-17]min and 13 [8-24]min, respectively)... (Complete abstract click electronic access below)
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Biggs, Morgan Eleanore. "Dietary supplementation of saccharin-based artificial sweeteners and capsicum oleoresin as a strategy to mitigate the negative consequences of heat stress on pig growth performance and intestinal physiology." Thesis, Virginia Tech, 2017. http://hdl.handle.net/10919/78279.

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Pigs exposed to elevated ambient temperatures exhibit reduced average daily gain, alterations in muscle and fat deposition during growth phases, and decreased overall health. Negative aspects of gastrointestinal (GI) function, integrity and permeability also result from hyperthermia. Saccharin-based artificial sweeteners have the potential to ameliorate the negative effects of heat stress (HS) by increasing GI GLP-2 production while capsicum oleoresin has been shown to reduce inflammatory response. Study objectives were to examine the effects of two artificial sweeteners, neohesperidin dihydrochalcone and saccharin, in combination with capsicum oleoresin (TakTik Sweet Heat , Pancosma, SA) on growth performance of pigs. Forty-eight pigs (12 weeks of age, 47.3 ± 7.6kg) were assigned to six treatments: thermal neutral conditions (21°C) fed ad libitum with (TN+) or without supplement (TN-), heat stress (35°C) fed ad libitum with (HS+) or without supplement (HS-), and thermal neutral conditions pair-fed to HS intake with (PFTN+) or without supplement (PFTN-). Dietary supplementation began 2 days prior to the 3-day environmental treatment period. Body weight was recorded on day -1 and day 3 relative to start of environmental treatment. Body temperature (BT) and respiration rate (RR) were measured thrice daily and feed intake (FI) were recorded daily. Blood samples were collected on day -1 and day 3 to determine metabolite profiles and immune response. Following sacrifice, sections of duodenum, ileum, and colon were collected for histology. Pigs in HS conditions had increased average BT and RR (~2.7-fold) compared to TN and PFTN groups (P<0.01). Irrespective of day, HS+ animals had increased respiration rates when compared to HS- animals (P<0.04). Heat stress decreased FI compared to TN groups. Regardless of treatment, supplement increased feed efficiency by 0.12kg (P<0.04). Circulating glucose concentration tended to decrease in HS+ and PFTN+ pigs compared to non-supplemented treatments (P=0.1). Circulating insulin increased in HS compared to PFTN (P<0.04), but did not differ from TN. Lymphocyte count tended to be decrease in HS compared to PFTN and TN (P=0.052). Monocyte count increased during HS compared to PFTN (P=0.01), but HS and TN did not differ. Supplement increased basophil count (P<0.03), irrespective of treatment. Ileal villus height tended to decrease during HS and PFTN compared to TN (P<0.08). Duodenal and colon villus height nor duodenal, ileal and colon crypt cell depth did not differ between groups. Overall, TakTik Sweet Heat supplementation increases pig feed efficiency and may improve immune response.<br>Master of Science
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Books on the topic "Saccharin"

1

United States International Trade Commission. Saccharin from China. U.S. International Trade Commission, 1994.

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Merki, Christoph Maria. Zucker gegen Saccharin: Zur Geschichte der künstlichen Süssstoffe. Campus Verlag, 1993.

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Commerce, United States Congress House Committee on. Saccharin notices: Report (to accompany H.R. 1787) (including cost estimate of the Congressional Budget Office). U.S. G.P.O., 1995.

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US GOVERNMENT. An Act to Amend the Federal Food, Drug, and Cosmetic Act to Repeal the Saccharin Notice Requirement. U.S. G.P.O., 1996.

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Lecos, Chris. Sweetness minus calories = controversy. Dept. of Health and Human Services, Public Health Service, Food and Drug Administration, 1987.

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United States. Congress. Senate. Committee on Labor and Human Resources. Saccharin Study and Labeling Act amendments of 1985: Report together with additional views (to accompany S. 484). U.S. G.P.O., 1985.

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Rasenberger, Herbert. Vom süssen Anfang bis zum bitteren Ende: 110 Jahre Fahlberg-List in Magdeburg--mehr als eine Betriebsgeschichte. Ziethen, 2009.

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United States. Congress. Senate. Committee on Labor and Human Resources. Saccharin Study and Labeling Act amendments of 1985: Hearing before the Committee on Labor and Human Resources, United States Senate, Ninety-ninth Congress, first session, on S. 484 ... April 2, 1985. U.S. G.P.O., 1986.

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United States. Congress. Senate. Committee on Labor and Human Resources. Saccharin Study and Labeling Act amendments of 1985: Report together with additional views (to accompany S. 484). U.S. G.P.O., 1985.

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United States. Congress. Senate. Committee on Labor and Human Resources. Saccharin Study and Labeling Act amendments of 1985: Hearing before the Committee on Labor and Human Resources, United States Senate, Ninety-ninth Congress, first session, on S. 484 ... April 2, 1985. U.S. G.P.O., 1986.

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Book chapters on the topic "Saccharin"

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Bährle-Rapp, Marina. "Saccharin." In Springer Lexikon Kosmetik und Körperpflege. Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-71095-0_9039.

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Bährle-Rapp, Marina. "Calcium Saccharin." In Springer Lexikon Kosmetik und Körperpflege. Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-71095-0_1512.

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Bährle-Rapp, Marina. "Sodium Saccharin." In Springer Lexikon Kosmetik und Körperpflege. Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-71095-0_9703.

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Dubois, Grant E. "Saccharin and Cyclamate." In Sweeteners and Sugar Alternatives in Food Technology. Wiley-Blackwell, 2012. http://dx.doi.org/10.1002/9781118373941.ch7.

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Haider, S. Z., K. M. A. Malik, K. J. Ahmed, George B. Kauffman, and Mohammad Karbassi. "Metal Complexes of Saccharin." In Inorganic Syntheses. John Wiley & Sons, Inc., 2007. http://dx.doi.org/10.1002/9780470132548.ch12.

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Benson, John, and Quentin Outram. "‘Saccharin’, Colliery Guardian (1886)." In Coal in Victorian Britain, Part I, Volume 1. Routledge, 2024. http://dx.doi.org/10.4324/9781003551034-22.

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Mohammad, Khairool Azizul, Syarifah Abd Rahim, and Mohd Rushdi Abu Bakar. "Nucleation Kinetics of Carbamazepine-Saccharin (CBZ-SAC) Co-crystal." In ICGSCE 2014. Springer Singapore, 2015. http://dx.doi.org/10.1007/978-981-287-505-1_31.

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Winnig, Marcel, Christina Kuhn, Oliver Frank, et al. "Saccharin: Artificial Sweetener, Bitter Tastant, and Sweet Taste Inhibitor." In Sweetness and Sweeteners. American Chemical Society, 2008. http://dx.doi.org/10.1021/bk-2008-0979.ch016.

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Carroll, Marilyn E., Nathan A. Holtz, and Natalie E. Zlebnik. "Saccharin Preference in Rats: Relation to Impulsivity and Drug Abuse." In Neuromethods. Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-104-2_13.

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Aslanova, E. T. "One-Stage Synthesis Method of Triglyceride of Saccharin-6-Carboxylic Acid." In Advanced Polymer Structures. Apple Academic Press, 2023. http://dx.doi.org/10.1201/9781003352181-43.

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Conference papers on the topic "Saccharin"

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Dioses, Isaac Angelo M., Jordan L. Mariano, Genesis C. Dela Peña, Patrick Neil M. Santiago, Joel A. Macaso, and Tranquilino J. Lucas. "Performance of Transfer Learning Method in Classification of Saccharum officinarum Diseases." In 2024 IEEE 12th Conference on Systems, Process & Control (ICSPC). IEEE, 2024. https://doi.org/10.1109/icspc63060.2024.10862842.

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Gabrovšek, Ana, Nika Tašler, Rigoberto Barrios-Francisco, and Marko Jeran. "Impact of a Saccharin Higher Homolog on Saccharomyces cerevisiae." In Socratic Lectures 7. University of Lubljana Press, 2022. http://dx.doi.org/10.55295/psl.2022.d15.

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Saccharin is an organic compound, which is often used as a calorie-free artificial sweetener. It salts are being produced for the market for over 80 years. Saccharin and its derivates are very applicatory oriented, therefore researchers synthesize more and more active ingredients, which could potentially show better performance. This work considers the effect of biological activity of a newly synthesized saccharin derivative Me- thyl 4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-3-carboxylate (6Sac) on yeast Saccharomyces cere-visiae. Qualitative comparison of the studied activity with the activity of the saccharine sodium salt is presented. Our results were gained by two different ways of viability detection: counting dead/live cells dyed with methylene blue and counting colony-forming units (CFU). The study has shown that the saccharine derivative with an ester functional group has negative effect on growth and repro-duction of yeast. The qualitative comparison of the activity of the tested substance with the already known activity of saccharine sodium salt is a convenient method for following the model organism Saccharomyces cerevisiae. Keywords: Saccharin, sodium saccharinate, Saccharomyces cerevisiae, Viability, Methylene blue, Col-ony-forming units (CFU), Medicine
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Mattos, Marcio C. S. de, and Marllon N. de Oliveira. "Ritter reaction of N-(hydroxymethyl)saccharin with nitriles: synthesis of new N-(amidomethyl)saccharins." In 15th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_2013715124551.

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Debnath, Niloy, Niloy Debnath, Jannatul Robaiat Mou, et al. "Saccharin Detection in Food Using Hollow-core Photonic Crystal Fiber." In 2020 IEEE Region 10 Symposium (TENSYMP). IEEE, 2020. http://dx.doi.org/10.1109/tensymp50017.2020.9230811.

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Umar, Salman, Nedita Putri Bandaro, Deni Anggraini, and Erizal Zaini. "Multicomponent Crystal of Fenofibric Acid- Saccharin: Characterization and Antihyperlipidemic Effectiveness." In 2nd International Conference on Contemporary Science and Clinical Pharmacy 2021 (ICCSCP 2021). Atlantis Press, 2021. http://dx.doi.org/10.2991/ahsr.k.211105.015.

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Riastuti, Rini, Achmad Rifki, Falah Herdino, Cika Ramadini, and Sonia Taruli Siallagan. "Effect of saccharin as additive in nickel electroplating on SPCC steel." In THE 6TH INTERNATIONAL CONFERENCE ON SCIENCE & ENGINEERING IN MATHEMATICS, CHEMISTRY AND PHYSICS: ScieTech18: The Nature Math - The Science. Author(s), 2018. http://dx.doi.org/10.1063/1.5080031.

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HERNÁDI, ISTVÁN, PÉTER KOVÁCS, ELEONÓRA VEISENBERGER, and LÁSZLÓ LÉNÁRD. "PREFRONTAL CORTICAL CORRELATES OF SACCHARIN REINFORCED LEARNING BEHAVIOR IN THE RAT." In Proceedings of the International School of Biocybernetics. WORLD SCIENTIFIC, 2002. http://dx.doi.org/10.1142/9789812776563_0025.

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Gvozdić, Eleonora, Ivana Matić-Bujagić, Tatjana Đurkić, and Svetlana Grujić. "Artificial Sweeteners in Groundwater as Indicators of Municipal Pollution." In 34th International Congress on Process Industry. SMEITS, 2021. http://dx.doi.org/10.24094/ptk.021.34.1.55.

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The widespread use of artificial sweeteners as additives in food, beverages, medicines and oral care products has led to the accumulation of these substances in aquatic ecosystems around the world. Since most of them are metabolically inert and are incompletely eliminated in wastewater treatment plants, municipal wastewater is the main source of these compounds in the environment. Due to the limited knowledge of their environmental fate and ecotoxicity, artificial sweeteeners are recognized as high-priority emerging contaminants. Some of them, such as acesulfame and sucralose, are very persistent in the aquatic environment, so they can be used as chemical markers of municipal wastewater pollution. In this paper, the presence of the most commonly used sweeteners in the Republic of Serbia (acesulfame, saccharin, cyclamate, sucralose and aspartame) was investigated in groundwater from two Belgrade Ranney wells, as well as in the Sava River, in order to assess the impact of untreated municipal wastewater on water sources, using liquid chromatography–tandem mass spectrometry.ers as additives in food, beverages, medicines and oral care products has led to the accumulation of these substances in aquatic ecosystems around the world. Since most of them are metabolically inert and are incompletely eliminated in wastewater treatment plants, municipal wastewater is the main source of these compounds in the environment. Due to the limited knowledge of their environmental fate and ecotoxicity, artificial sweeteeners are recognized as high-priority emerging contaminants. Some of them, such as acesulfame and sucralose, are very persistent in the aquatic environment, so they can be used as chemical markers of municipal wastewater pollution. In this paper, the presence of the most commonly used sweeteners in the Republic of Serbia (acesulfame, saccharin, cyclamate, sucralose and aspartame) was investigated in groundwater from two Belgrade Ranney wells, as well as in the Sava River, in order to assess the impact of untreated municipal wastewater on water sources, using liquid chromatography–tandem mass spectrometry.
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Hodges, M., and R. McKay. "165. A Comparison of Sodium Saccharin Versus Controlled Negative Pressure for Detecting Known Leaks in Full Face Respirators." In AIHce 2001. AIHA, 2001. http://dx.doi.org/10.3320/1.2765681.

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Costantino, Andrea, Sandra Mandolesi, and Liliana Koll. "Michael Addition of Phthalimide and Saccharin to Enantiomerically Pure Diesters of BINOL and TADDOLs Derivatives Under Microwave Conditions." In The 18th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2014. http://dx.doi.org/10.3390/ecsoc-18-c012.

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Reports on the topic "Saccharin"

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Flórez Martínez, Diego Hernando, and Nicolle Tatiana Castillo Galindo. Contexto de cadena panela (Saccharum officinarum). Corporación colombiana de investigación agropecuaria - AGROSAVIA, 2020. http://dx.doi.org/10.21930/agrosavia.fichascontexto.2020.24.

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En esta ficha de contexto se mencionan los aspectos importantes de la cadena de panela enfocados a su marco productivo, regional, económico, comercio internacional, así como sus perspectivas y tendencias frente al mercado, dando a conocer su entorno de Ciencia y Tecnología e Innovación.
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Beniers, J. E., S. Bras, and A. K. Werf. Cryopreservation of Ulva spp. and Saccharina latissima: : optimised protocols of cryopreservation, recovery and (long-term) regrowth of Ulva spp. and Saccharina latissima gametophytes and sporophytes. Stichting Wageningen Research, Wageningen Plant Research, Business Unit Agrosystems research, 2023. http://dx.doi.org/10.18174/640169.

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Castillo Galindo, Nicolle Tatiana. Contexto de cadena caña de azúcar (Saccharum ocinarum). Corporación colombiana de investigación agropecuaria - AGROSAVIA, 2020. http://dx.doi.org/10.21930/agrosavia.fichascontexto.2020.7.

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En esta ficha de contexto se mencionan los aspectos importantes de la cadena de caña de azúcar (Saccharum ocinarum) enfocados a su marco productivo, regional, económico, comercio internacional, así como sus perspectivas y tendencias frente al mercado, dando a conocer su entorno de Ciencia y Tecnología e Innovación.
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Bragg, Don C., and Douglas D. Stokke. Field identification of birdseye in sugar maple (Acer saccharum Marsh.). U.S. Department of Agriculture, Forest Service, North Central Research Station, 1994. http://dx.doi.org/10.2737/nc-rp-317.

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Bennett, Neal. Drying hard maple (Acer saccharum L.) lumber in a small dehumidification kiln. U.S. Department of Agriculture, Forest Service, Northern Research Station, 2013. http://dx.doi.org/10.2737/nrs-rn-196.

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Todd, James, and Jack C. Comstock. Discovering the desirable alleles contributing to the lignocellulosic biomass traits in saccharum germplasm collections for energy cane improvement. Office of Scientific and Technical Information (OSTI), 2015. http://dx.doi.org/10.2172/1226911.

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Wang, Jianping, and Hardev Sandhu. Discovering the desirable alleles contributing to the lignocellulosic biomass traits in Saccharum germplasm collections for energy cane improvement. Office of Scientific and Technical Information (OSTI), 2017. http://dx.doi.org/10.2172/1347688.

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Vargas Berdugo, Ángela María, Ayda Fernanda Barona Rodríguez, Leidy Yibeth Deantonio Florido, and Nancy del Carmen Barreto Triana. Principales enfermedades que afectan el cultivo de caña de azucar (Saccharum spp.) en regiones paneleras: tecnologías para el sector panelero. Corporación colombiana de investigación agropecuaria - AGROSAVIA, 2020. http://dx.doi.org/10.21930/agrosavia.video.2020.5.

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Khadakkar, Suvarna S., Ashish D. Tiple, and Arun M. Khurad. Description of developmental stages of Phyllognathus dionysius Fabricius, 1792 (Insecta, Coleoptera, Scarabaeidae) with notes on biology from central India. Austrian Academy of Sciences, 2025. https://doi.org/10.1553/biosystecol.4.e142543.

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Detailed description of the 3rd instar larva and pupa of Phyllognathus dionysius is described along with notes on biology and distribution. Some beetles belonging to the family Scarabaeidae are economically important as crop pests. Grubs of P. dionysius are coprophagus and polyphagous and known to feed on roots of jowar (Sorguhm bicolor), bajra (Pennisetum glaucum), maize (Zea mays), turmeric (Curcuma longa), sugarcane (Saccharum officinarum) and paddy (Oryza sativa) while adults are nocturnal in habit and feed on foliage of Ficus sp. For this study, grubs of P. dionysius were collected from the Bor forest of Maharashtra, central India. Collected grubs were reared in rearing pots in the laboratory under optimum temperature and humidity. Our knowledge of developmental stages of scarabs lags behind our knowledge of the adults especially in the fields of morphology and taxonomy. In this study, we provide brief diagnostic characters for identification of the immature stages of P. dionysius along with the biology. Life cycle of P. dionysius was completed in 145–163 days with prepupal period of 24–36 hours and pupal period of 9–11 days.
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López Lopera, Juan Gonzalo, Ayda Fernanda Barona Rodríguez, and Leidy Yibeth Deantonio Florido. Proceso de evaluación de nuevas de caña de azúcar (Saccharum spp.) para la producción de panela: CC 93-7711 y CC 93-7510 de AGROSAVIA. Corporación colombiana de investigación agropecuaria - AGROSAVIA, 2020. http://dx.doi.org/10.21930/agrosavia.video.2020.6.

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En la agroindustria de la panela se presenta un bajo rendimiento de la caña, para enfrentar esta problemática la selección de nuevas variedades resulta de gran utilidad para el sector. Este proceso contribuye a; aumentar la cantidad de caña y panela por hectárea, buscar la tolerancia a plagas y enfermedades, lograr precocidad en los siclos de producción, obtener buena calidad de la panela, reducir costos de producción y conseguir la aceptación de los productores.
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