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Pinsak, Samantha. "Everything is not sawa sawa: Abuse and informal employment in Kenya." Thesis, Boston College, 2016. http://hdl.handle.net/2345/bc-ir:106847.
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Thesis advisor: Can ErbilViolence against women and subsequent gender-based violence are issues that plague the world, harming women’s wellbeing as well as that of their families. Thirty-nine percent and twenty-one percent of Kenyan women have experienced physical and sexual violence, respectively, in their lifetimes. While there have been contested studies showing that employment can both increase and decrease the risk of suffering from violence, particularly in domestic settings, this study examines how a Kenyan woman’s experience of violence is likely to affect her level (formal or informal) of employment in the future. The results of this study indicate that emotional abuse, having a partner that drinks, educational attainment, living in a rural setting, and age are significant factors in a woman’s probability of working. Conditioned on working, experiencing controlling behaviors from a partner, educational attainment, justification of violence, ethnicity, income rank, partner’s occupation, and age at first marriage influence a woman’s probability of working informally. These results vary based on the type of employment studied, but can have wide-ranging consequences for the economic development of Kenya and empowerment of Kenyan women
Thesis (BA) — Boston College, 2016
Submitted to: Boston College. College of Arts and Sciences
Discipline: Departmental Honors
Discipline: Economics
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Ohenoja, L. (Laura). "Martinniemen saha kulttuuriperintöprosessin rattaissa." Master's thesis, University of Oulu, 2018. http://urn.fi/URN:NBN:fi:oulu-201809222826.
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Tutkimus käsittelee Martinniemen sahaa kulttuuriperinnön näkökulmasta. Suunnitelmat sahan purkamisesta herättivät paikalliset ajamaan sahan piipun suojelua. Käynnistyi kulttuuriperintöprosessi, jossa erilaisten tunteiden, muistojen ja kokemusten kautta yritettiin saada piipusta valtakunnallisesti suojeltu kulttuuriperintö kohde. Paikallisille koko sahan historia ja kulttuuriperintö kiteytyi lopulta piippuun ja piipusta tuli konkreettinen kohde, joka kiteytti ja säilytti kulttuuriperintöä. Paikallisten kautta tutkimuksessa tarkastelen yhteisöllistä kulttuuriperintönäkökulmaa. Millainen suhde paikallisilla oli sahaan ja mikä oli sahan ja sen luoman kulttuuriperinnön merkitys heille?
Yksilöllisen kulttuuriperintönäkökulman tutkimukseen tuovat sahalla vierailevat ihmiset, joilla ei ole aikaisempaa suhdetta sahaan. Raunioituneissa rakennuksissa vierailevat harrastajat muodostivat erilaisia henkilökohtaisia suhteita paikkaan. Tarkoituksessa ja ihmisestä riippuen hylätty voimalaitos saattoi merkitä seikkailua, jännitystä, piilopaikkaa, leikkikenttää tai paikkaa, jossa päästä toteuttamaan itseään. Urban explorer harrastajat, valokuvaajat ja graffititaiteilijat vierailivat sahan hylätyissä, rapistuvissa rakennuksissa ja erilaisten henkilökohtaisten kokemuksiensa kautta loivat merkityksiä rakennuksille.
Tutkimuksen aineistona olivat sahan voimalaitos ja piippu. Vierailin Laitakarin saarella, jossa voimalaitos ja piippu sijaitsivat, kolme kertaa tutkimusta tehdessäni 8.9.2016, 4.10.2017 ja 29.5.2018. Ensimmäisellä vierailulla tutustuin voimalaitoksen sisätiloihin, toisella vierailulla ympäristöön ja kolmannella vierailulla kävin katsomassa paikkaa, kun rakennukset oli purettu pois. Tutkimuksessa tarkastelin suojelun uutisointia ja erilaisia blogeja ja YouTube videoita sahan voimalaitoksella tapahtuneista vierailuista. Paikallisten luomaa kulttuuriperintöprosessia tarkastelin uutisissa esiin tulleiden erilaisten haastattelujen kautta, joissa perusteltiin piipun säilyttämistä. Voimalaitoksen merkitystä raunioharrastajille tarkastelin heidän tekemiensä nettijulkaisuiden kautta.
Paikallisille koko sahan olemassaolo kiteytyi lopulta piippuun, jonka suojelun puolesta he taistelivat vuosia. Heille sahan kulttuuriperinnöstä muodostui miltei elävä olento, joka tarvitsi konkreettisen ilmentymän, jotta se säilyisi. Paikallisen kulttuuriperintö ja valtakunnallinen kulttuuriperintö eivät lopulta kohdanneet Martinniemen sahan piipun kohdalla ja kaikki rapistuneet rakennukset purettiin pois.
Valtakunnallisella, yhteisöllinen ja yksilöllisellä kulttuuriperinnöllä on erilaiset lähtökohdat ja määritelmät. Martinniemen sahan tapauksessa valtakunnallinen ja yhteisöllinen kulttuuriperintönäkökulma ajautuivat konfliktiin, kun taas yksilöllinen kulttuuriperintönäkökulma pysyi erillään suojelusta, koska suojeltuna tai purettuna, rakennuksilla ei enää ollut heille käyttötarkoitusta.
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Soliman, Salwa Mosad [Verfasser]. "Modeling of hSULT1A1 Metabolism / Salwa Mosad Soliman." Berlin : Freie Universität Berlin, 2017. http://d-nb.info/1137206608/34.
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Taha, Shadia. "Attachment to abandoned heritage : the case of Suakin, Sudan." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610432.
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Honkonen, L. (Lassi). "Pruukin Saha Yhtiö 1900–1912:ihmisten työpaikka — ihmisten yhteisö." Master's thesis, University of Oulu, 2016. http://urn.fi/URN:NBN:fi:oulu-201605051643.
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Tässä opinnäytteessä tarkastellaan Ruukin sahayhtiötä vuosina 1900–1912 eli osakeyhtiö G. & C. Bergbom A/B:n aikana yrityksen liiketoiminnan, työtehtävien ja palkkauksen, työyhteisön arkielämän ja työläisyyden muodostumisen näkökulmista. Pruukin Saha Yhtiö oli tutkimusajanjakson aikana monialayritys, jonka toimialaan kuuluivat puutavaranjalostuksen ohella tiilenvalmistus sekä maa- ja karjatalouden harjoittaminen.
Pääosan tutkielman arkistolähteistä muodostavat Ruukinsahan kassakirjat vuosilta 1901–1905 ja 1905–1907 sekä työlistakirjat vuosilta 1905–1907 ja 1909–1913. Toinen merkittävä osa tutkimuksen lähteistä koostuu tutkimusajanjakson aikana ilmestyneiden sanomalehtien Ruukin sahaa koskevasta uutisoinnista. Näistä keskeisimpiä ovat Kansan Tahto, Kaiku, Kaleva ja Raahen Sanomat. Tutkimusta täydentävinä lähteinä käytetään kolmea muistelmaluontoista kirjallista teosta.
Tätä tutkimusta tehtäessä on käytetty kolmea erilaista tutkimusmenetelmää: historiantutkimukselle tyypillistä lähdekriittistä menetelmää, lähteiden lähilukua ja tilastollisia menetelmiä kassa- ja työlistakirjojen numeraalista materiaalia hyödyntäen.
Maaseutumainen rauha rikkoutui Ruukissa viimeistään vuoden 1905 suurlakosta alkunsa saaneen työläisten järjestäytymisen myötä. Joukkovoima mursi paikkakunnalla siihen saakka vallinneen yksinapaisen paternalistisen järjestyksen ja tehdastyöväestö muodosti hyvin aktiivisen ja näkyvän, varteenotettavan voimatekijän kylän sosiaalisessa järjestyksessä. Tehdastyöläisiä yhdisti toisiinsa sosialismiaatteeseen nojautuva työväenyhdistys, jonka jäseninä kilpailevien yritysten työläiset pääsivät yhdessä osoittamaan joukkovoiman mahtia työnantajiaan kohtaan.
Ruukin sahayhtiön tehdasyhdyskunnan elämää leimasi arkinen työ ja jatkuva muutos. Työntekijöiden oli sopeuduttava paitsi luonnonolosuhteiden vaihtelun tuomiin haasteisiin myös kahden eri tehtaan teknisten muutosten vaatimiin lukuisiin erilaisiin työtehtäviin — unohtamatta henkistä sopeutumista vuosisadan uusiin aatevirtauksiin ja nopeasti kasvavan tehdaskylään elämänrytmiin.
Raahen sahayhtiön rakennuttaessa Ruukkiin suuren sahalaitoksen vuosisadan alussa, jäi ”Vanha Saha” toimialallaan kilpailijaansa huomattavasti pienemmäksi toimijaksi. Sahan työntekijät saivat opetella kokonaan uuden teollisen prosessin (tiilitehtaan) työvaiheet, heti kun olivat saaneet rakennettua tehdasrakennuksen valmiiksi.
Sosiaalisia epäkohtia vuosisadan alun Ruukissa kuvastavat aikakaudelle melko tyypilliset piirteet, kuten naisten alempi palkkaustaso, tehdastyön vaarallisuus ja heikko oikeudellinen asema irtisanottaessa niin vuokra- kuin työsuhteestakin. Leimaa-antavana piirteenä koko tutkimusajanjakson aikana oli oululaisten Bergbom-sukuisten omistajien fyysinen poissaolo tehdasalueelta.
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Saha, Shekhar [Verfasser]. "Outcomes of complex valve surgery in elderly patients / Shekhar Saha." Magdeburg : Universitätsbibliothek, 2017. http://d-nb.info/115232134X/34.
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Saha, Arpan [Verfasser], and Vicente [Akademischer Betreuer] Cortés. "Twists of quaternionic Kähler manifolds / Arpan Saha ; Betreuer: Vicente Cortés." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2020. http://d-nb.info/1214811701/34.
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Saha, Mahasweta [Verfasser]. "Anti-settlement defence of Fucus vesiculosus : Chemistry and ecology / Mahasweta Saha." Kiel : Universitätsbibliothek Kiel, 2011. http://d-nb.info/1020245042/34.
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Zagni, Chiara. "Progettazione e sintesi di nuovi inibitori delle istone deacetilasi." Thesis, Università degli Studi di Catania, 2011. http://hdl.handle.net/10761/253.
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Il controllo epigenetico dell'espressione genica e' operato da modifiche post-translazionali della cromatina, quali acetilazione e deacetilazione. Due enzimi sono respinsabili di questo processo: le HAT (istone acetiltransferasi) e le HDAC (istone deacetilasi). Le HDAC sono un gruppo di enzimi coinvoilti nella regolazione dell'espressione genica, nella riparazione de DNA e nella risposta allo stress. L'acetilazione gioca un ruolo importante nella trascrizione poiche' responsabile del rimodellamento della cromatina aumentando l'accesso dei fattori di trascrizione al DNA. Una diminuzione dei livelli dell'acetilazione istonica sono associate con un aumento dell'attivita' di trascrizione, mentre un decremento dei livelli di acetilazione e associate con le repression della repressione genica. Infatti nelle cellule tumoralisi osserva frequentemente un'anormale espressione genica.
Gli inibitori delle HDAC (HDI) sono potenti induttori dell'arresto della crescita, della differenzione e della morte dellulare per apoptosis in cellule trasformate sia in vitro che in vivo. Ad oggi vi sono sette classi distinte di inibitori delle HDAC e tutti contengono tre elementi strutturali chiave del farmacoforo:
a) un gruppo legante lo zinco (R), che coordina gli ioni zinco al fondo della lunga e stretta cavita' del sito attivo;
b) un cappuccio o à ¢ capà ¢ (la funzione solfonammidica), che interagisce sia con gli aminoacidi sul margine del sito di legame sia con la superficie della proteina.
c) un dominio di legame, il cui ruolo e' assicurare il corretto posizionamento dei gruppi precedenti e di interagire con il canale di legame lipofilo.
Seguendo il nostro recente interesse nella ricerca di HDI piu' potenti, ho progettato e sintetizzato una nuova serie di composti contenenti quattro nuove porzioni chelanti lo zinco, quali formilidrazonometilica,
2-formilidrazinocarbonilica, 2,2,2-trifluoro-N-metilencetammidica e 2,2,2-trifluoro-N-metilacetammidica, legate attraverso uno spaziatore ad una solfonammide (Schema 1), responsabile dell'interazione idrofobica con l'HDAC. Studi di docking hanno mostrato che queste molecule si inseriscono perfettamente nella tasca enzimatica dell'HDAC con un ottimo à ¯ Gbind di à ¢ 7,9 kcal/mol che e' una 1 kcal/mol piu' bassa del SAHA, un ottimo inibitore.The epigenetic control of gene expression is operated through post-translational modifications of chromatin such as acetylation and deacetylation. Two enzymes are responsable for these processes: HAT (histone acetyl transferase) and HDAC (histone deacetylase). HDAC is a group of enzymes involved in regulating gene expression, DNA repair and stress response. Acetylation plays an important role in trascription because it remodels chromatin structure enhancing access to DNA-binding factors. In general, increased levels of histone acetylation are associated with increased transcriptional activity, whereas decreased levels of acetylation are associated with repression of gene expression. In tumor cells abnormal gene expression is frequently observed. HDAC inhibitors have been shown to be potent inducers of growth arrest, differentiation, and apoptotic cell death both in vitro and in vivo transformed cells. To date there are seven distinct classes of HDAC inhibitors and all contain three key structural elements to their pharmacophore: a) a zinc-binding group which coordinates the zinc ion at the bottom of the long narrow active site cavity; b) a capping group which interacts both with the amino acids on the rim of the binding cavity and the protein surface; c) a linker domain whose role is to ensure the correct positioning of the two former groups and to in-teract with the lipophilic binding tunnel. Following our recent interest in the research of more potent HDAC inhibitors, we have projected and synthesized a new series of compounds containing four new zinc chelant moieties, i.e. formylhydrazonomethyl, 2-formylhydrazinocarbonyl, 2,2,2-trifluoro-N-methylideneacetamidic and N-(trifluoroacetyl)amidic, linked by an aromatic spacer to an aromatic sulfonamide, that is responsible of hydrophobic interaction with HDAC. Docking studies have shown that these new molecules fit very good in the HDAC enzymatic pocket with a best ï Gbind of â 7,9 kcal/mol that is 1 kcal/mol lower of the corresponding one for SAHA, a good HDAC.
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Saha, Sanjib [Verfasser]. "Determination of effective charge of flexible polyelectrolytes by light scattering / Sanjib Saha." Mainz : Universitätsbibliothek Mainz, 2013. http://d-nb.info/1030425655/34.
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Rodriguez, Julie Paulin Garcia. "Abordagens alternativas para a obtenção de novos metabólitos secundários produzidos a partir de linhagens fúngicas." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/75/75133/tde-06022019-161858/.
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Neste trabalho foram estudadas duas abordagens para a obtenção de novos metabólitos secundários a partir de fungos. Na primeira, o ácido hidroxâmico suberoilanilida (SAHA) e cinco análogos foram sintetizados. Sua atividade como modificadores epigenéticos foi avaliada em oito linhagens fúngicas do ambiente marinho. Os fungos Penicillium sp. e Acremonium sp. apresentaram modificações no seu perfil metabolómico quando foram crescidos em pequena escala em presença do derivado 4F-SAHA, enquanto Microphaeropsis sp. apresentou modificação em presença do 3AM-SAHA. O fungo P. decaturense foi crescido em maior escala e os compostos de interesse foram isolados. Na segunda abordagem, uma nova estratégia de extração utilizando mistura de resinas XAD 2-4-7 permitiu a extração e posterior isolamento de seis novos alcaloides peptídicos (72-77) e dois peptídeos (78-79) a partir da fração aquosa do meio de cultivo do fungo antártico Penicillium solitum IS1-A. Utilizando a mesma metodologia, o metabolismo secundário do fungo antártico Thelebolus globosus E2 foi estudado. A partir de seu extrato metanólico do meio liquido PDB foram isoladas a ciclopenina (86) e o ciclopenol (87) e foram detectados os alcaloides viridicatina (88) e viridicatol (89). O fungo Thelebolus globosus mostrou-se produtor de estatinas, sendo isoladas como composto majoritário a mevastatina (90).In this work two approaches to obtain new secondary metabolites from fungi were studied. Suberoylanilide hydroxamic acid (SAHA) and five analogues were synthesized and assessed as epigenetic modifiers in eight marine-derived fungi. The fungus Penicillium sp. and Acremonium sp. presented changes in their metabolomic profile when they were grown on a small scale in presence of 4F-SAHA derivative and Microphaeropsis sp. presented a modification in the presence of the 3 AM-SAHA. In the second approach a new extraction strategy using XAD 2-4-7 resin mixture allowed the extraction and subsequent isolation of six new peptide alkaloids (72-77) and two peptides (78-79) from the aqueous fraction of the culture medium of the Antarctic fungus Penicillium solitum IS1-A. Using the same methodology, the secondary metabolism of the Antarctic fungus Thelebolus globosus E2 was studied. From the methanolic extract of the PDB liquid medium cyclopenine (86) and cyclopenol (87) were isolated and the viridicatine (88) and viridicatol (89) alkaloids were detected. The fungus Thelebolus globosus was shown to be a producer of statins, mainly of mevastatin (90).
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PARIGI, GIOVANNI. "STATO E TRIBU' NEL MEDIO ORIENTE CONTEMPORANEO: DINAMICHE DI POTERE NELL'IRAQ DI OGGI." Doctoral thesis, Università Cattolica del Sacro Cuore, 2013. http://hdl.handle.net/10280/1873.
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Il tribalismo costituisce una caratteristica intrinseca delle società mediorientali, concorrendo insieme a cultura araba e religione islamica a comporne l’identità. In Iraq, da sempre, il tribalismo ha costituito sia una struttura organizzativa ed una modalità di relazione sociale, che una dinamica di potere. Durante il Mandato britannico e la monarchia, la manipolazione politica di cultura e strutture tribali ha rafforzato la legittimazione del governo; nella fase repubblicana, con l’emergere delle forze armate quale principale attore politico e l’impatto con la modernità, il tribalismo si è trasformato pur rimanendo radicato nella società. Nella fase iniziale del regime ba’thista, la cultura tribale è stata combattuta essendo considerata un retaggio arcaico. Senonchè, con le difficoltà legate alla guerra con l’Iran, l’invasione del Kuwait e il successivo embargo, il regime di Saddam Hussein sfruttò proprio il tribalismo sia come dinamica di presa e controllo del potere che come collante propagandistico e sociale. Nel vuoto politico seguito al crollo del regime, le tribù riemersero come “campo di battaglia” tra insurgency e forze della Coalizione. Con il Surge americano e la nascita della Sahwa quale reazione allo stragismo jihadista, le tribù hanno impresso una svolta che ha salvato il paese dalla guerra settaria. Anche al Maliki ha saputo abilmente avvantaggiarsi del fenomeno tribale. Oggi le tribù continuano a rappresentare sia una constituency imprescindibile per ogni partito politico, che una diversificata e trasversale forza politica attiva.Tribalism is an intrinsic character of Middle Eastern’s societies, as it contributes, together with Arab culture and Islamic religion, to shape their identity. In Iraq, since ever, tribalism constituted an organizational structure and a pattern of social relations, as well as dynamic of power’s exercise. Under the British Mandate and the Monarchy, politic manipulation of tribal’s culture and structures strengthened government’s legitimation; during the Republican period, as the Army emerged as main political driver and the influence of Modernity, tribalism transformed itself even if its presence into the society was still very strong. In the initial phase of Ba’thist’s regime, tribal culture was opposed, since it was considered as an obsolete heritage. But, facing the difficulties stemming from the war with Iran, the invasion of Kuwait and the embargo, the regime of Saddam Hussein exploited tribalism as a dynamic of power’s control, as well as propaganda and social bond. In the political void ensuing to the collapse of the regime, the tribes surfaced as “battlefield” between insurgency and Coalition’s Forces. American Surge and the tribes’ intervention in the Sahwa, as a reaction to jihadist’s bloodbath, avoided a sectarian civil war. Also al Maliki was able to exploit the tribal system. Nowadays, tribes are still an invaluable constituency for every political party, as well as diversified and a cross-parties political force.
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PARIGI, GIOVANNI. "STATO E TRIBU' NEL MEDIO ORIENTE CONTEMPORANEO: DINAMICHE DI POTERE NELL'IRAQ DI OGGI." Doctoral thesis, Università Cattolica del Sacro Cuore, 2013. http://hdl.handle.net/10280/1873.
Full textAbstract:
Il tribalismo costituisce una caratteristica intrinseca delle società mediorientali, concorrendo insieme a cultura araba e religione islamica a comporne l’identità. In Iraq, da sempre, il tribalismo ha costituito sia una struttura organizzativa ed una modalità di relazione sociale, che una dinamica di potere. Durante il Mandato britannico e la monarchia, la manipolazione politica di cultura e strutture tribali ha rafforzato la legittimazione del governo; nella fase repubblicana, con l’emergere delle forze armate quale principale attore politico e l’impatto con la modernità, il tribalismo si è trasformato pur rimanendo radicato nella società. Nella fase iniziale del regime ba’thista, la cultura tribale è stata combattuta essendo considerata un retaggio arcaico. Senonchè, con le difficoltà legate alla guerra con l’Iran, l’invasione del Kuwait e il successivo embargo, il regime di Saddam Hussein sfruttò proprio il tribalismo sia come dinamica di presa e controllo del potere che come collante propagandistico e sociale. Nel vuoto politico seguito al crollo del regime, le tribù riemersero come “campo di battaglia” tra insurgency e forze della Coalizione. Con il Surge americano e la nascita della Sahwa quale reazione allo stragismo jihadista, le tribù hanno impresso una svolta che ha salvato il paese dalla guerra settaria. Anche al Maliki ha saputo abilmente avvantaggiarsi del fenomeno tribale. Oggi le tribù continuano a rappresentare sia una constituency imprescindibile per ogni partito politico, che una diversificata e trasversale forza politica attiva.Tribalism is an intrinsic character of Middle Eastern’s societies, as it contributes, together with Arab culture and Islamic religion, to shape their identity. In Iraq, since ever, tribalism constituted an organizational structure and a pattern of social relations, as well as dynamic of power’s exercise. Under the British Mandate and the Monarchy, politic manipulation of tribal’s culture and structures strengthened government’s legitimation; during the Republican period, as the Army emerged as main political driver and the influence of Modernity, tribalism transformed itself even if its presence into the society was still very strong. In the initial phase of Ba’thist’s regime, tribal culture was opposed, since it was considered as an obsolete heritage. But, facing the difficulties stemming from the war with Iran, the invasion of Kuwait and the embargo, the regime of Saddam Hussein exploited tribalism as a dynamic of power’s control, as well as propaganda and social bond. In the political void ensuing to the collapse of the regime, the tribes surfaced as “battlefield” between insurgency and Coalition’s Forces. American Surge and the tribes’ intervention in the Sahwa, as a reaction to jihadist’s bloodbath, avoided a sectarian civil war. Also al Maliki was able to exploit the tribal system. Nowadays, tribes are still an invaluable constituency for every political party, as well as diversified and a cross-parties political force.
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Sakha, Sahra [Verfasser]. "Essays on risk preferences and peer effects in household decision-making : experimental evidence / Sahra Sakha." Hannover : Technische Informationsbibliothek (TIB), 2016. http://d-nb.info/1095504274/34.
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Sakwa, Imme [Verfasser]. "Characterization of orthopox ankyrin repeat proteins in the modified vaccinia virus Ankara background / Imme Sakwa." Berlin : Freie Universität Berlin, 2014. http://d-nb.info/1048327418/34.
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Srinivasaraghavan, Vaishnavi. "A Microfabricated Bioimpedance Sensor with Enhanced Sensitivity for Early Breast Cancer Detection." Thesis, Virginia Tech, 2011. http://hdl.handle.net/10919/46202.
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Bioimpedance is the term given to the complex impedance value that is characteristic of the resistance that biological cells offer to the flow of electric current. The objective of this study is to analyze the differences in the bioimpedance of highly metastatic MDA-MB-231 and normal MCF 10A breast epithelial cells and use this information to detect a very small number of breast cancer cells present in a background of normal breast cells and other cells that are typically present in a human biopsy sample.To accomplish this, a bioimpedance sensor with flat gold microelectrodes on a silicon substrate was designed and fabricated. Suberoylanilide hydroxamic acid (SAHA), an FDA-approved anti-cancer agent was used to improve the sensitivity of the bioimpedance sensor towards cancer cells by selectively modifying their cytoarchitecture.Master of Science
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Batschinski, Karen. "Avaliação da eficácia da 5-Azacitidina e SAHA nas linhagens de hemangiossarcoma canino." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5155/tde-27032018-132505/.
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O hemangiossarcoma é uma neoplasia maligna de origem endotelial vascular de ocorrência comum em cães. Nessa espécie, o órgão primário mais acometido é o baço. O hemangiossarcoma de partes moles em cães é caracterizado por ter um comportamento biológico muito agressivo e metástases, principalmente para o pulmão e fígado, são frequentes e ocorrem de maneira rápida no início do curso da doença. O óbito ocorre na maioria dos casos devido a hemorragia interna aguda secundária à ruptura do tumor e/ou devido ao processo metastástico. A cirurgia continua a ser o principal método de tratamento para quase todos os cães com hemangiossarcoma, mas a quimioterapia adjuvante é indicada em razão do alto índice metastático e do prognóstico ruim associado com o procedimento cirúrgico sozinho. Um estudo retrospectivo foi realizado para determinar o tempo de sobrevida e potenciais fatores de risco em cães diagnosticados com hemangiossarcoma visceral. Prontuários de 42 cães foram revisados. Dados como idade e peso no momento do diagnóstico, raça, sexo, localização do tumor, estágio clínico da doença, tipo de tratamento, e tempo mediano de sobrevida foram analisados. Vinte e três cães foram tratados apenas com cirurgia, enquanto que 19 cães foram tratados com cirurgia e quimioterapia adjuvante. Houve diferença estatística na sobrevida dos cães tratados com cirurgia e Doxorrubicina (274 dias) em comparação com cães tratados apenas com cirurgia (66 dias). Cães com hemangiossarcoma esplênico tiveram um tempo mediano de sobrevida mais longo do que os cães com hemangiossarcoma localizados em outros sítios primários e com metástase (274 versus 117 versus 38 dias, respectivamente, p = 0,013). O tempo mediano global de sobrevida para esses 42 cães foi de 237 dias, e a taxa de sobrevida de um ano foi estimada em 26,32%. Conclui-se que a localização primária do hemangiossarcoma teve associação com o prognóstico e que o uso da Doxorrubicina após o tratamento cirúrgico aumentou a sobrevida dos cães diagnosticados com essa doença. Neste estudo, o estadiamento clínico dos cães não influenciou o prognósticoHemangiosarcoma is a very common canine neoplasm of vascular endothelial origin. In the dog, the most frequent primary site for hemangiosarcoma is the spleen. Typically, canine hemangiosarcoma has a very aggressive biologic behavior with metastases, especially to lung and liver, occurring early in the course of the disease. In the majority of cases, death is related to acute hemoabdomen secondary to tumor rupture and/or metastases. Surgery remains the main method of treatment for most dogs with this type o cancer, but adjuvant chemotherapy is highly recommended due to the high risk of metastasis and the poor outcome associated with surgery alone. A retrospective study was performed to determine survival times and potential risk factors in dogs diagnosed with visceral hemangiosarcoma. Medical records of 42 dogs were reviewed. Age and baseline weight at the time of diagnosis, breed, sex, tumor location, clinical stage of the disease, treatment type and median survival time were evaluated. Twenty-three dogs were treated with surgery alone, while 19 dogs were treated with surgery and adjuvant chemotherapy. There was significant difference in survival between dogs treated with surgery alone (66 days) and with surgery followed by Doxorubicin (274 days). Dogs with splenic hemangiosarcoma had a longer median survival time than dogs with hemangiosarcoma of other sites, and with metastasis (274 versus 117 versus 38 days, respectively, p = 0,013). The overall median survival time for these 42 dogs was 237 days, and the one-year survival rate was estimated to be 26.32%. In conclusion, primary tumor location was associated with prognosis and the addition of doxorubicin after surgery did improve survival. In this study, clinical stage had no association with prognosis
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Moundo, Elizabeth E. "La mort, le deuil et les conduites funéraires chez les Sawa du Cameroun." Rennes 2, 1986. http://www.theses.fr/1986REN20016.
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Cette étude sur la mort, le deuil et les conduites funéraires est une tentative de réflexion sur l'homme, à partir de trois dimensions : ontologique, éthique et métaphysique. Chez les Sawa du Cameroun, il y a deux aspects dans les conduites funéraires : l'un liturgique et l'autre thérapeutique. Ces deux aspects gèrent à la fois l'équilibre de la personne et celui de la communauté. L'analyse des conduites montre qu'elles sont signifiantes. Par conséquent, la scène funéraire est une structure totale de représentation. L'espace de la mort, modifié lors de l'avènement de la mort, est hierophanisé. Il y a une mise en scène d'un drame qui permet l'émergence de signifiants majeurs pour expulser le mal introduit par la mort. Les personnages signifiants sont : le mort et la veuve le mort, dont le corps est sublimé, magnifié, à travers l'esthétique et l'harmonie, devient une "figure" symbolique. La veuve est prise en charge en trois temps : le "procès", la condamnation, la renaissance. La réparation va se signifier à deux niveaux : le changement de nom et l'attribution d'une nouvelle couleur qui symbolise le veuvage. La veuve devient à la fois métaphore de la communauté et métonymie du mal. La mise en parallèle des deux personnages signifiants fait apparaître deux paradigmes : la précarité - l'évanescence, le désordre, l'ordre de la mort ; la permanence, l'ordre, l'harmonie, l'ordre de la vie. Du point de vue thérapeutique, le traitement du mort et la prise en charge de la veuve sur la scène funéraire, permet l'émergence d'un "nous" funéraire qui est l'affirmation d'un "nous" communautaire. L'ensemble amène à une réflexion sur la mort comme "mal", et la quête du sens de la mort comme quête du sens de la vieThis study on death, mourning and funerals conducts, is a tentative reflexion on man in three dimensions : ontological, ethical, and metaphysical. For example with the Sawa of Cameroon, there exist two aspects of funerals conducts; one liturgical and the other therapeutic. These two aspects manage the equilibrium of the individual as well as that of the community involved. There is significance in the analysis of these conducts. Then, the scene of the funerals is entirely representational structure. The space of death, modified on the arrival of death is sacred. This dramatic production allows the emergence of significants majors in order to expel the "evil" of death. The principal significant persons being the dying and the widow. The body of the dying person concerned is magnified and subinised by the way of aesthetic and harmony, until it becomes a symbolical "figure". The widow is taken care on three stages: the "prosecuted", the condemnation and the rebirth. The purpose of which is significant on two levels: the change of the name and the attribution of a colour symbolical of widowhood. Thus the widow as metaphor of the community as well as the metonymy of "evil". The parallel setting of these two persons engenders two paradigms: the precariosity the disorder, the unbalance, the order of death; the permanence, the order, the harmony, and order of life. From a therapeutic point of view, the treatment of dying person and the charge of the widow on the scene of funerals, permits the emergence of a funeral "us" as an affirmation of the community "us". This brings us to the reflexion of death as "evil" and the search for meaning of death as a search for the meaning of life
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Alizadehbirjandi, Atefeh. "Polymeric drug delivery vehicles for encapsulation and release of SAHA histone deacetylase inhibitors." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1546447766963075.
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Ewombe-Moundo, Elizabeth. "La Mort, le deuil et les conduites funéraires chez les Sawa du Cameroun." Lille 3 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb37599839g.
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Biz, Chiara <1992>. "HISTORIAS DE LOCOS Cuentos de locura de Miguel Sawa Traducción y análisis literario." Master's Degree Thesis, Università Ca' Foscari Venezia, 2020. http://hdl.handle.net/10579/16844.
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El presente trabajo consiste en la traducción inédita de Historias de Locos, una recopilación de cuentos de locura, escrito por Miguel Sawa y publicado póstumo en 1910. Asimismo, se cuenta y examina la vida del autor, breve pero marcada por un talento inusual para la escritura y un profundo interés por la ciencia y la cultura. Además, en esta tesis se analizarán no sólo las temáticas tratadas por el autor, que son variadas y diferentes entre ellas, sino también el estudio traductológico, y algunas consideraciones con respecto a la introducción por parte de Miguel Sawa de temas interesantes para un lector moderno.
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Catarina, Adair Santa. "SAHGA - Um algoritmo genético híbrido com representação explícita de relacionamentos espaciais para análise de dados geoespaciais." Instituto Nacional de Pesquisas Espaciais, 2009. http://urlib.net/sid.inpe.br/mtc-m18@80/2009/03.19.13.53.
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A dependência espacial é um conceito fundamental em análise geográfica. Tem sua origem na Primeira Lei da Geografia, assim denominada em homenagem ao geógrafo e matemático norte-americano Waldo Tobler, que enunciou que quando tratamos com fenômenos geográficos tudo está relacionado, mas as coisas próximas estão mais relacionadas do que coisas distantes. Este princípio mostra a importância de se considerar os relacionamentos espaciais na análise geográfica a partir dos dados geoespaciais. Entretanto, uma classe de algoritmos heurísticos utilizados na análise de dados geoespaciais, os Algoritmos Genéticos, negligenciam os relacionamentos espaciais e, conseqüentemente, os efeitos da dependência espacial. Nesta tese desenvolveu-se o SAHGA - Spatially Aware Hybrid Genetic - Algorithm um algoritmo heurístico híbrido com representação explícita de relacionamentos espaciais. O algoritmo desenvolvido incorpora a GPM (Generalized Proximity Matrix) para representar as associações espaciais entre objetos geoespaciais; em outras palavras os relacionamentos espaciais. O algoritmo SAHGA une duas heurísticas: Algoritmos Genéticos e Simulated Annealing. Desenvolveu-se dois sistemas que utilizam o algoritmo SAHGA: o SAHGA Model Breeder (SAHGA MB) e o SAHGA Species Distribution Models (SAHGA SDM). Utilizou-se o SAHGA MB na análise de dados sócio-econômicos e o SAHGA SDM na modelagem da distribuição potencial das espécies Strix varia Barton (1799) e Thalurania furcata boliviana Boucard (1894). Os dois sistemas desenvolvidos foram utilizados no ajuste de modelos ignorando, ou não, os relacionamentos espaciais. Comparou-se os resultados para averiguar os efeitos dos relacionamentos espaciais sobre os modelos ajustados. Também utilizou-se o algoritmo GARP, disponível no software openModeller Desktop, para criar modelos de distribuição de espécies que foram comparados com os modelos ajustados pelo SAHGA SDM. Os resultados obtidos mostram que os sistemas desenvolvidos ajustam modelos úteis. Os modelos ajustados pelo SAHGA MB e os modelos ajustados pelo SAHGA SDM são afetados pelos relacionamentos espaciais; os efeitos causados pelos relacionamentos espaciais dependem do conhecimento representado na GPM.The spatial dependence is a fundamental concept in spatial analysis. The spatial dependence results from that everything is related to everything else, but near things are more related than distant things. Spatial data analysis may use heuristic algorithms as Genetic Algorithms; however, these algorithms ignore the spatial dependence. In this work we present the SAHGA Spatially Aware Hybrid Genetic Algorithm a Hybrid Heuristic Algorithm with explicit representation of spatial relationships. The proposed algorithm includes a Generalized Proximity Matrix (GPM) to represent the spatial association between objects in space, in other words the spatial relationships. SAHGA embody two heuristics: Genetic Algorithms and Simulated Annealing. We developed two software with SAHGA: SAHGA Model Breeder (SAHGA MB) and SAHGA Species Distribution Models (SAHGA SDM). The SAHGA MB was used in social data analysis and the SAHGA SDM was used to model the potential distribution of Strix varia Barton (1799) and Thalurania furcata boliviana Boucard (1894) species. Both software may be used to create models with and without spatial relationships. We compared the adjusted models, with and without spatial relationships, to observe the effects of spatial relationships. We also compared the created SDM with GARP models. The results obtained show that the developed software may adjust useful models. Model breeder and species distribution models were affected by spatial relationships; the effects of relationships are function of the knowledge represented by the GPM.
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Cázares, Marinero José De Jesús. "Synthèse, caractérisation et évaluation des effets biologiques des hybrides "FcTAM-SAHA" et composés dérivés." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2013. http://tel.archives-ouvertes.fr/tel-00954959.
Full textAbstract:
Dans le cadre de la poursuite de l'exploration des effets anticancéreux des complexes ferrocéniques du tamoxifène, nous avons préparé une série de complexes hybrides résultant de la substitution de la chaîne latérale du ferrocifène (FcTAM) par celle du SAHA, un inhibiteur des histones-déacétylases (HDACi) utilisé dans le traitement de certains lymphomes. A partir de la structure hybride " FcTAM-SAHA ", cinq types de modifications ont été réalisées. Il s'agit [1] de la modification de la fonction acide hydroxamique (CONHOH) en fonction amide primaire (CONH2) ou acide carboxylique (COOH), [2] de la variation de la longueur de la chaîne latérale, [3] de la présence ou non d'un substituant sur le cycle aromatique, [4] de la substitution du métallocène et [5] du remplacement du groupement ferrocényle par un phényle. Les effets antiprolifératifs des nouveaux complexes ont été étudiés sur deux lignées de cancer du sein, MDA-MB-231 (lignée hormono-indépendante et triple-négative) et MCF-7 (lignée hormono-dépendante). Un effet synergique de la toxicité est observé en série FcTAM-SAHA sur les deux lignées cellulaires. De façon un peu inattendue, nous avons trouvé que l'effet antiprolifératif des hybrides phénoliques (type FcOHTAM-SAHA) et des hybrides ferrocénophaniques (type FnTAM-SAHA) était comparable voire légèrement inférieur à celui des complexes non hydroxylés (type FcTAM-SAHA). Cette observation semble indiquer que les propriétés redox des molécules ne s'expriment pas de façon identique pour les précurseurs et les hybrides. Dans tous les cas, les complexes porteurs d'une fonctionnalité chimique acide hydroxamique ou amide primaire sont plus cytotoxiques que les acides carboxyliques et ces effets sont peu influencés par la longueur de la chaîne latérale. Enfin, dans tous les cas, les complexes ferrocéniques ont des effets antiprolifératifs supérieurs à leurs analogues organiques. Cette différence souligne l'importance de la présence du motif ferrocénique et de ses propriétés redox uniques.
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Hiltula, K. (Kimmo). "Korpilakkoja vai leipätaisteluja?:pohjoisten sanomalehtien suhtautuminen Peräpohjolan vuosien 1920 ja 1926 saha- ja satamalakkoihin." Master's thesis, University of Oulu, 2016. http://urn.fi/URN:NBN:fi:oulu-201612013144.
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Tutkielmassa on selvitetty, kuinka paljon neljän puolueen pohjoisimmat äänenkannattajat kirjoittivat Kemin seudun saha- ja satamalakoista kesinä 1920 ja 1926. Lisäksi tutkielmassa on analysoitu kirjoitetusten sisältöä sekä selvitetty syitä, miksi lehtien sivuilla päätyivät kyseiset kirjoitukset. Tarkastelussa on ollut pääkirjoitusten lisäksi myös tapahtumauutiset sekä yleisönosastokirjoitukset. Eri tyyppisiä kirjoituksia lähestytään lähtökohtaisesti saman arvoisina, sillä kaikki lehtien sivuille päätyneet kirjoitukset julkaistiin lehdentekijöiden suostumuksella.
Lehtien julkaisemista kirjoituksista on tutkielmassa tehty määrällinen analyysi, jossa ilmenee kirjoitusten määrän lisäksi niissä esiintyneet aiheet ja teemat. Aiheet on jaettu kolmeen ryhmään: lakon oikeutukseen, lakkoon liittyviin väkijoukkoihin ja muihin aiheisiin. Aiheet puolestaan on jaettu teemoihin. Lakon oikeutuksen kohdalla teemat ovat lakon näkeminen joko palkkataisteluna tai laittomana lakkona eli korpilakkona, jolla oli poliittisia tavoitteita. Väkijoukkokirjoitusten teemoina olivat lakkoilevat työläiset ja lakon aikana töitä tekevät ihmiset, niin värvätyt lakonmurtajat kuin värväämättömätkin. Ryhmä muut on jaettu neljään teemaan: taloutta, julkisen vallan käyttöä, ulkomaita sekä työnantajien muuta kuin lakkoon liittyvää toimintaa käsitelleisiin. Tutkielman sivumääristä suurin osa on käytetty kirjoitusten sisällölliseen analyysiin sekä kirjoituksissa esitettyjen asioiden kytkeytymisessä lakkojen ulkopuoliseen maailmaan, varsinkin poliittiseen ajatteluun. Sisällön tutkimisessa metodi on historiallis-kvalitatiivinen ja sidoksissa poliittisen historian tutkimuksen traditioon.
Tarkastelun kohteena olevat sanomalehdet olivat puolueidensa pohjoisimpia äänenkannattajia. Kemissä ilmestynyt Pohjolan Sanomat oli Oulun pohjoisen vaalipiirin valtapuolueen, maalaisliiton äänenkannattaja. Tutkimusajankohtana niin Pohjan Kansan kuin Pohjan Voimankin nimellä ilmestynyt sanomalehti oli kommunistinen. Oulussa ilmestynyt lehti oli ilmoittautunut kulloisenkin laillisen, kommunistisen puolueen tai vaaliliiton äänenkannattajaksi. Tornion Lehti oli edistyspuolueen, Perä-Pohjolainen ja Perä-Pohja kokoomuksen äänenkannattajia.
Pohjolan Sanomat suhtautui lakon osapuolista myötämielisemmin lakkoilijoihin kuin Kemi-yhtiöön ja muihin työnantajiin. Pohjolan Sanomien linjasta määräsi vahvasti lehden päätoimittaja Uuno Hannula, joka oli aatemaailmaltaan alkiolainen ja sijoittui maalaisliiton sisällä puoluevasemmistoon. Pohjolan Sanomat korosti molempina tarkasteluaikoina lakkojen palkkataisteluluonnetta. Pohjolan Sanomat asettui alkiolaisuuden hengessä köyhän asialle. Lisäksi Hannulan ja tärkeimmän työnantajan, Kemi-yhtiön välejä rasittivat Pohjolan Sanomien aikaisemmat kirjoitukset yhtiön kylmäkiskoisuudesta työntekijöitään kohtaan. Pohjolan Sanomat vastusti kuitenkin kommunismia. Vuoden 1926 lakon yhteydessä Pohjolan Sanomat vaati aktiivisesti valtion sovittelua. Vaatimus myös toteutui. Pohjolan Sanomat oli muita tutkittuja lehtiä kiinnostuneempi lakon taloudellisista vaikutuksista osapuoliin sekä ympäröivään yhteiskuntaan. Pohjan Kansan ja Pohjan Voiman näkemys työtaisteluista oli ymmärrettävästi vahvasti lakkoilijoiden puolella. Lehden uutiset ja muut kirjoitukset olivat usein vanhan työväenliikkeen perinteen mukaisia, puolueorganisaatiolla ei ollut mahdollisuuksia määrittää yksittäisten kirjoitusten sisältöä. Toimittajat joutuivat uutisoinnissaan itse tulkitsemaan kommunismia, kirjoittajien äärivasemmistolaisuudesta ei ollut epäilystäkään. Vuoden 1920 lakkojen aikaan Perä-Pohjolainen asettui vahvasti työnantajan näkemysten kannalle, sen mukaan palkankorotusvaatimukset olivat vain savuverho, jonka taakse häivytettiin todellinen, tavoite työläisten vaiktuksvallan kasvattaminen, jopa vallankumouksen valmistelu. Perä-Pohjolainen asettui repression, puhdistuksen linjalle, kun Pohjolan Sanomat kannatti integraatiota, kansakunnan eheyttämistä. Tornion Lehden rooli lakkokirjoittelussa jäi vähäiseksi. Lehti oli pääosin ulkopuolinen ja neutraali, ainoan kerran linjasta livetessään Tornion Lehti oli vahvasti työnantajan puolella. Sisällissodan jälkeinen aika, 1920-luku oli suomalaisessa sanomalehdistössä voimakkaimmin poliittista aikaa. Lehtien sitoutuminen oli aatteellista, puolueilla ei välttämättä ollut omistuksellista suhdetta äänenkannattajiinsa.
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Cázares-Marinero, José de Jesús. "Synthèse, caractérisation et évaluation des effets biologiques des hybrides « FcTAM-SAHA » et composés dérivés." Paris 6, 2013. http://www.theses.fr/2013PA066393.
Full textAbstract:
Dans le cadre de la poursuite de l’exploration des effets anticancéreux des complexes ferrocéniques du tamoxifène, nous avons préparé une série de complexes hybrides résultant de la substitution de la chaîne latérale du ferrocifène (FcTAM) par celle du SAHA, un inhibiteur des histones-déacétylases (HDACi) utilisé dans le traitement de certains lymphomes. A partir de la structure hybride « FcTAM-SAHA », cinq types de modifications ont été réalisées. Il s’agit [1] de la modification de la fonction acide hydroxamique (CONHOH) en fonction amide primaire (CONH2) ou acide carboxylique (COOH), [2] de la variation de la longueur de la chaîne latérale, [3] de la présence ou non d’un substituant sur le cycle aromatique, [4] de la substitution du métallocène et [5] du remplacement du groupement ferrocényle par un phényle. Les effets antiprolifératifs des nouveaux complexes ont été étudiés sur deux lignées de cancer du sein, MDA-MB-231 (lignée hormono-indépendante et triple-négative) et MCF-7 (lignée hormono-dépendante). Un effet synergique de la toxicité est observé en série FcTAM-SAHA sur les deux lignées cellulaires. De façon un peu inattendue, nous avons trouvé que l’effet antiprolifératif des hybrides phénoliques (type FcOHTAM-SAHA) et des hybrides ferrocénophaniques (type FnTAM-SAHA) était comparable voir légèrement inférieur à celui des complexes non hydroxylés (type FcTAM-SAHA). Cette observation semble indiquer que les propriétés redox des molécules ne s’expriment pas de façon identique pour les précurseurs et les hybrides. Dans tous les cas, les complexes porteurs d’une fonctionnalité chimique acide hydroxamique ou amide primaire sont plus cytotoxiques que les acides carboxyliques et ces effets sont peu influencés par la longueur de la chaîne latérale. Enfin, dans tous les cas, les complexes ferrocéniques ont des effets antiprolifératifs supérieurs à leurs analogues organiques. Cette différence souligne l’importance de la présence du motif ferrocénique et de ses propriétés redox uniquesPursuing our exploration on anticancer activity of tamoxifen ferrocene derivatives, we have synthesized a series of hybrid complexes resulting from the substitution of ferrocifen (FcTAM) side chain with SAHA, a histone-deacetylase inhibitor (HDACi) used in the treatment of certain lymphomas. From FcTAM-SAHA hybrid, five types of modifications have been performed. They are [1] modification of the hydroxamic acid function (CONHOH) with a primary amide (CONH2) and a carboxylic acid (COOH), [2] variation of the side chain length, [3] with or without an aromatic substituent, [4] substitution of the metallocene and [5] substitution of the ferrocenyl unit with a phenyl group. The antiproliferative effects of the new complexes have been studied on two breast cancer cell lines, MDA-MB-231 (hormone-independent and triple-negative cell line) and MCF-7 (hormone-dependent cell line). A synergistic effect of the toxicity was observed in series FcTAM-SAHA on both cell lines. Surprisingly, no increase in toxicity was observed in the phenolic (FcOHTAM-SAHA-type) and in ferrocenophane (FnTAM-SAHA-type) hybrids. This observation suggests that the redox properties of the molecules are not expressed in the same way for precursors and hybrid compounds. In general, the hydroxamic acids and primary amides are more cytotoxic than carboxylic acids and these effects are not influenced by the length of the side chain. Finally, we found that the ferrocenic compounds are always more cytotoxic than their organic analogs. This difference highlights the importance of the presence of the ferrocenic moiety associated with its unique redox properties
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Guimarães, Douglas Magno. "Uso de inibidores de Histona Deacetilase como estratégia terapêutica para sensibilizar células-tronco tumorais a quimioterapia: uma nova visão terapêutica sobre carcinomas mucoepidermoide bucais." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/23/23141/tde-21092015-164942/.
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Carcinoma mucoepidermóide (CME) é o tumor maligno de glândulas salivares mais comum, representando cerca de 30% dos tumores malignos. O tratamento do CME é a ressecção cirúrgica com eventual radioterapia. Assim, o tratamento do CME pode levar a varias complicações estéticas e funcionais. A quimioterapia tem sido utilizadas apenas em casos recorrentes ou com metástases à distancia. Vários relatos na literatura tem mostrado que o tratamento com drogas isoladas ou combinadas possuem uma resposta insatisfatória e de curta duração em grande parte devido a aquisição de resistência a quimioterapia. Recentemente, a quimiorresistência tem sido relacionada com a presença de Células-Tronco Tumorais (CTT). Essa resistência tem sido associada ao fato de que as essa células são quiescentes e possuem altos níveis de proteínas associadas ao reparo do DNA e baixos níveis das proteínas que levam a apoptose. Recentemente mostrou-se que a resistência a quimioterapia tem sido relacionada com modificações de histonas, uma vez que as células quimiorresistentes possuem núcleo pequeno e baixos níveis de acetilação de histonas, adicionalmente as células sensíveis são relacionadas com núcleo aumentado. O objetivo desse estudo foi avaliar os efeitos do tratamento com IHDAC e cisplatina sobre a população de CTT de CME. Inicialmente analisamos os níveis de acetilação do histona através da expressão imuno-histoquímica de acetil histona H3 em casos de CME, sendo encontrado altos níveis de acetilação de histona principalmente nas células epiteliais do ducto excretor. Adicionalmente, demonstramos que o tratamento com SAHA (inibidor de histona deacetilase) impacta diretamente a população de CTT, de uma maneira mais eficiente do que a cisplatina ou da combinação de SAHA e cisplatina. É interessante que o tratamento com cisplatina resultou no acúmulo de uma subpopulação especifica de CTT em um processo que inclui o aumento na expressão da via de sinalização do mTOR. Estes achados sugerem que o uso de IHDAC constitui uma forma eficiente de tratamento de CME através da depleção da população de CTT , porém mais estudos são necessários para validar estes achados para uso clinico.Mucoepidermoid carcinoma (MEC) is the most common malignant salivary tumor compromising about 30% of all salivary malignances. Managing MEC patients remain challenging especially due to the heterogeneous response of tumor cells to available therapy. For this reason clinical outcome remains unpredictable. Current treatment of MEC encompasses surgical resection with eventual adjuvant radiotherapy, which frequently leads to functional and aesthetic complications. The use of chemotherapy is often reserved for recurrent and metastatic tumors. Administration of single-agent or combination therapy has showed activity, however overall response rates are unsatisfactory and of short duration. Emerging evidences suggest that the modest response of tumor cells to therapy resulting in high recurrence rates and poor survival, are associated with the presence of cancer stem cells (CSC). Quiescence of CSC is achieved by the reduced levels of transcription in a process that requires tight folding of DNA driven by core histone proteins. Changes in DNA folding are responsible for different cellular phenotypes mediated by a cell type-specific chromatin organization. Of interest, we also found that acetylation of HNSCC tumor histones driven by histone deacetylase (HDAC) inhibitors abrogate tumor resistance to chemotherapy. We investigate the effects of HDACi and cisplatin in the population of CSCs of MEC. Initially, we found that MEC tumors are composed by a heterogeneous population of squamous-like and mucous-like cells presenting distinct acetylation levels of histone 3 (Lys9). Tumor cells where treated with cisplatin and SAHA, a Food and Drug Administration (FDA) approved histone deacetylase inhibitor. Surprisingly, we found that administration of SAHA resulted in complete depletion of MEC CSCs. In facts, SAHA alone surpassed the inhibitory therapeutic effects of cisplatin and the combined therapy using SAHA and cisplatin over the population of CSCs. We also found that administration of cisplatin to MEC tumor cells result in unexpected accumulation of a sub population of CSC (paraclones), suggesting a correlation between the administration of intercalating agents such as cisplatin to the development of resistance of MEC cells to chemotherapy.
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Holm, Sara, and Fatima Kashoush. "SAHA-studien : En uppföljningsstudie av långtidseffekter och upplevelser av IKBT-behandling för arabisktalande i Sverige." Thesis, Linköpings universitet, Institutionen för beteendevetenskap och lärande, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-165884.
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År 2019 gjordes SAHA-studien vid Linköpings universitet där internetadministrerad kognitiv beteendeterapi gavs till arabisktalande i Sverige med depressions- och ångestproblematik med samtidiga komorbida tillstånd. Terapin var kulturellt anpassad samt skräddarsydd för denna population. De utfallsmått som nyttjades var Patient Health Questionnaire, Generalised Anxiety Disorder 7-item scale, Insomnia Severity Index, Perceived Stress Scale 14-item scale, Impact of Event Scale Revised och Brunnsviken Brief Quality of Life Inventory (PHQ-9, GAD-7, ISI, PSS-14, IES-R 22, BBQ). Resultaten i den var lovande. Den nuvarande studien avsåg att följa upp eventuella långtidseffekter för dessa symtomminskningar samt kvalitativt undersöka upplevelsen av att ha deltagit i denna IKBT-behandling. Denna studie var således en mixed method studie som både nyttjade de ovan nämnda utfallsmåtten, telefonintervjuer samt tematisk analys. Resultatet visar på signifikanta långtidseffekter för depression, stress och PTSD, men inte för ångest, insomni och livskvalitet. Den tematiska analysen genererade sex olika teman kring deltagarnas upplevelser av IKBT-behandlingen som belyser både aspekter som tidigare lyfts i forskning kring denna population samt nya aspekter gällande behoven hos denna population för effektiv internetbehandling. Mer forskning behövs emellertid inom detta område då denna studie utifrån författarnas kännedom var den första av sitt slag i Sverige.
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Saha, Susanne [Verfasser]. "Einfluss von Schmerzen auf die gesundheitsbezogene Lebensqualität bei Patienten mit systemischem Lupus erythematodes / Susanne Saha." Bonn : Universitäts- und Landesbibliothek Bonn, 2011. http://d-nb.info/1016248636/34.
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Yavari, Sahra [Verfasser], and Ali [Akademischer Betreuer] Gorji. "Heilpflanzen und ihre Wirkung in der Mundhöhle : die vermutete und die wissenschaftlich untersuchte / Sahra Yavari. Betreuer: Ali Gorji." Münster : Universitäts- und Landesbibliothek der Westfälischen Wilhelms-Universität, 2011. http://d-nb.info/1017643393/34.
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Bektas, Sahra [Verfasser]. "Wachstumsentwicklung von Zwillingen in den ersten zwei Lebensjahren nach intrauteriner Laserablation bei fetofetalem Transfusionssyndrom / Sahra Bektas. Medizinische Fakultät." Bonn : Universitäts- und Landesbibliothek Bonn, 2011. http://d-nb.info/1017915504/34.
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Dunstan, Neal Edward. "Steps to the identification of the residue of the cultural heritage landscape of the University of Pretoria's Hatfield campus 1910-1960." Diss., University of Pretoria, 2016. http://hdl.handle.net/2263/61291.
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As the Campus Landscape Architect for the University of Pretoria, it has been an on-going challenge to gain an understanding and reliable data on the history of the landscape of the University of Pretoria's Hatfield campus. With the pace of development taking place on the campus, in order to meet the University's 2025 Strategic Vision, it became very clear that potential significant cultural landscapes on the Hatfield campus could be lost without ever knowing it. This is especially even more so when related to the South African Heritage Resources Act 25 of 1999 (SAHRA). The Getty Foundation's Campus Heritage Initiative's first grant for a conference in 2000 shared consensus that historic landscape preservation had a very low profile in much of American campus planning
The hypothesis states that the University of Pretoria's Hatfield Campus has an undiscovered cultural landscape history that not only could have value to the development of the University, but also to that of the surrounding precincts of the City. The thesis's aim is to record any sourced data pertaining to the cultural landscape of the University of Pretoria's Hatfield campus in order to contribute to the institutional repository, and to ascertain what, if any, cultural landscape values exist. A complex descriptive and historiographical interpretative research strategy was followed. A literature, policy and model study was conducted resulting in the main research tool being the U.S. Department of the Interior National Park Service's Cultural Landscape Report (CLR). The limitation to the thesis was Part 1: Site History, Existing Conditions, Analysis and Evaluation of the CLR to the University of Pretoria's Hatfield Campus for the period 1910 to 1960.
The study highlighted that the Hatfield Campus does contain tangible cultural landscape elements but very little is known or present of the intangible elements. The current political climate of the University places emphasis on equalising the cultural diversity on campuses, perhaps to the detriment of the existing cultural landscape, mainly by the naming and/or renaming of its buildings. A recommendation is that a Management and Preservation Plan encompassing both the architectural and landscape aspects be compiled to inform the future planning of the campus.Dissertation (MLA)--University of Pretoria, 2016.
Architecture
MLA
Unrestricted
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Ngametche, Robinson. "Le festival Ngondo afro-monde de Montréal comme adaptation de l'identité culturelle des Sawa au Canada." Thesis, Université Laval, 2013. http://www.theses.ulaval.ca/2013/30112/30112.pdf.
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Le Ngondo est l’assemblée traditionnelle et la fête annuelle des peuples Sawa au Cameroun. Sawa signifie à la fois « côte » et « berge » en langue duala, qui représente l’ensemble des peuples installés depuis le XVe siècle sur les rives du fleuve Wouri et les côtes camerounaises de l’océan Atlantique. La fête du Ngondo soulève beaucoup de passions de nos jours, soit pour décrier sa pratique, soit pour épiloguer sur son origine, soit pour souligner ses lettres de noblesse, mais très peu souvent pour explorer le processus de son évolution et son éventuelle réinvention en pays étranger. Mon travail aborde la question du Ngondo dans cette perspective d’évolution et d’adaptation en terre étrangère. Je me limite à son aspect festif en faisant une étude comparative entre la fête du Ngondo au Cameroun et au Canada, à Montréal, afin de savoir comment les Sawa ont pu adapter cette fête à un nouveau contexte et comment elle sert à construire leur identité culturelle.
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Podadera, Carlos. "Constructions of the body through the Gothic idiom in three 'radical naturalist' novels of Alejandro Sawa." Thesis, Anglia Ruskin University, 2018. http://arro.anglia.ac.uk/703815/.
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This thesis considers instances of corporeality in three novels (Crimen legal, Criadero de curas and Noche) by Spanish novelist Alejandro Sawa (1862-1909) from the point of view of anti-clerical Gothic aesthetics. Despite the presence of many a literary Gothic element in these novels, these works had traditionally been considered mere by-products of the influence of French naturalist author Emile Zola (1840-1902). This would be due to the “radical naturalist” sobriquet which Sawa himself chose to identify his novels with. However, this thesis contests such considerations of Sawa as a “naturalist” author and focuses instead on the Gothic influences received through French Romanticism, Spanish popular novels of the fin-du-siècle and anti-clerical propaganda, previously unexplored. The exploration of the works considered will be guided by theories such as Julia Kristeva’s concept of “abjection” or affect theory, at the core of which lies a concern with the body and/or the corporeal. In reading Sawa’s oeuvre under a Gothic lens of corporeality, aspects of his work which had been previously unacknowledged come to the forefront. Such aspects are, for example, Sawa’s dependency on the middle-class representational idiom he allegedly so much despised, or the relationship of his novels with the anti-clerical, misogynistic nation-building project of Spain in the late nineteenth century. The image of the Spanish realist canon and the perception and understanding of Zola’s works within the Spanish letters in the last third of the nineteenth century, especially with regards to corporeality, are now more nuanced, as is Sawa’s literary standing.
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Podadera, Carlos. "Constructions of the body through the gothic idiom in three "radical naturalist" novels of Alejandro Sawa." Thesis, Anglia Ruskin University, 2018. https://arro.anglia.ac.uk/id/eprint/703815/1/Podadera_2018.pdf.
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This thesis considers instances of corporeality in three novels (Crimen legal, Criadero de curas and Noche) by Spanish novelist Alejandro Sawa (1862-1909) from the point of view of anti-clerical Gothic aesthetics. Despite the presence of many a literary Gothic element in these novels, these works had traditionally been considered mere by-products of the influence of French naturalist author Emile Zola (1840-1902). This would be due to the “radical naturalist” sobriquet which Sawa himself chose to identify his novels with. However, this thesis contests such considerations of Sawa as a “naturalist” author and focuses instead on the Gothic influences received through French Romanticism, Spanish popular novels of the fin-du-siècle and anti-clerical propaganda, previously unexplored. The exploration of the works considered will be guided by theories such as Julia Kristeva’s concept of “abjection” or affect theory, at the core of which lies a concern with the body and/or the corporeal.
In reading Sawa’s oeuvre under a Gothic lens of corporeality, aspects of his work which had been previously unacknowledged come to the forefront. Such aspects are, for example, Sawa’s dependency on the middle-class representational idiom he allegedly so much despised, or the relationship of his novels with the anti-clerical, misogynistic nation-building project of Spain in the late nineteenth century. The image of the Spanish realist canon and the perception and understanding of Zola’s works within the Spanish letters in the last third of the nineteenth century, especially with regards to corporeality, are now more nuanced, as is Sawa’s literary standing.
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DeGraffenried, Jeffries Blunt. "Rapid prediction of tropical soil degradation using diffuse reflectance spectroscopy method verification in the Saiwa River basin, western Kenya /." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2010r/degraffenried.pdf.
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Dlamini, Samkeliso Mpendulo Dlamini. "Synthesis and Biological Evaluation of HDAC Inhibitors with 1-(1H-imidazol-2-yl)ethan-1-one Moiety as the Metal-Binding Group." University of Toledo / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1501770195684609.
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Saha, Sayantan [Verfasser], and Dirk W. [Akademischer Betreuer] Heinz. "Structural insight into the biosynthesis of molybdenum cofactor and heme d1 / Sayantan Saha ; Betreuer: Dirk W. Heinz." Braunschweig : Technische Universität Braunschweig, 2013. http://d-nb.info/1175821276/34.
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Ciuchi, Carrasco Pía Karina. "Evaluación farmacológica in vitro de SAHA y carboplatino en un alínea de carcinoma oral de células escamosas." Tesis, Universidad de Chile, 2017. http://repositorio.uchile.cl/handle/2250/144058.
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Trabajo de Investigación Requisito para optar al Título de Cirujano DentistaEl carcinoma oral de células escamosas (COCE) es el tipo más común de enfermedades malignas orales, teniendo una sobrevida de aproximadamente 56% a los 5 años. El tratamiento que se administra en etapas avanzadas incluye radioterapia, quimioterapia y cirugía. El fármaco más utilizado es cisplatino, a pesar de que se ha evidenciado una alta tasa de fracaso y recidiva, además de los efectos secundarios producido por el tratamiento. Es por esto que se han evaluado diversos compuestos farmacológicamente activos, con actividad citotóxica, como quimiosensibilizadores o moduladores de la resistencia a fármacos. Es en este ámbito que el desarrollo de inhibidores de histona desacetilasas (iHDAC) pueden ser utilizados en el tratamiento para COCE, ya que el aumento de las histonas desacetilasas contribuye a la expresión aberrante de genes, existiendo por ende una relación entre la desacetilación de histonas y la iniciación y progresión tumoral. El propósito de este trabajo es evaluar el efecto de ácido hidroxámico suberoilanilida (SAHA), un iHDAC, en células tumorales orales, tanto por sí solo como en combinación con carboplatino, este último debido a que presenta menos efectos adversos que cisplatino. Lo que se propone es que existe un efecto antitumoral citotóxico sinérgico de SAHA y Carboplatino in vitro en líneas tumorales de COCE. Para llevar esto a cabo se utilizó una línea tumoral oral, CAL27. Para medir citotoxicidad se utilizó el ensayo colorimétrico 3-(4,5dimethythiazol-. 2-yl)-2,5-diphenyl bromuro de tretazolio (MTT) y para evaluar el efecto en la migración celular se desarrolló el ensayo de herida. Se analizaron los datos usando t-test Student u ANOVA. Como resultados se observó que SAHA presenta un efecto dosis y tiempo dependiente, además en combinación con carboplatino presenta efecto citotóxico estadísticamente significativo con respecto al control y a cada tratamiento por separado, observándose entre ellos un efecto sinérgico. Además SAHA es un potente inhibidor de la migración celular en comparación con carboplatino. Esto sugiere que se requiere una mayor evaluación de los efectos de SAHA para considerarlos como un coadyuvante a la quimioterapia antineoplásica.
Adscrito a Proyecto Fondecyt 11140281
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El-Ghannam, Sahra [Verfasser]. "Radiologisch-histopathologische Korrelation : Untersuchung des Zusammenhangs zwischen dem Kontrastmittelenhancement in der MR-Mammographie und der Kapillardichte von Brustläsionen / Sahra El-Ghannam." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2011. http://d-nb.info/1026069084/34.
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Saha, Aurpita [Verfasser]. "Barrier layers in the tropical Atlantic Ocean: Growth and decay mechanisms and impact of Amazon river runoff / Aurpita Saha." Hamburg : Staats- und Universitätsbibliothek Hamburg Carl von Ossietzky, 2020. http://d-nb.info/1236284739/34.
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FIGUEIREDO, MARCIO B. "Espectroscopia de plasma gerado por laser em regime temporal de nanosegundos e femtosegundos em padrões de aço inoxidável ferrítico." reponame:Repositório Institucional do IPEN, 2007. http://repositorio.ipen.br:8080/xmlui/handle/123456789/11566.
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Made available in DSpace on 2014-10-09T12:53:20Z (GMT). No. of bitstreams: 0Made available in DSpace on 2014-10-09T14:09:35Z (GMT). No. of bitstreams: 0
Dissertacao (Mestrado)
IPEN/D
Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP
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Aydemir, Burak. "Corporate Governance : An Empirical Analysis of the Relationship between SAHA’s Corporate Governance Rating Scores and Firm Performance at Istanbul Stock Exchange." Thesis, Södertörns högskola, Institutionen för samhällsvetenskaper, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-17380.
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This study examines the relationship between SAHA’s corporate governance rating score and firm performance in Turkey for the period between 2008, 2009 and 2010. The purpose of study is to analyze whether there is a relationship between Saha’s corporate governance score which is based on the principles of Capital Market Board of Turkey and firm performance for 16 companies listed in corporate governance index Istanbul Stock Exchange (ISE) by using Saha’s Corporate Governance. It also aims to determine this relationship by attempting to answer the question of whether better governed firms as measured by high corporate governance score have higher firm performance in Turkey. With this purpose three analyses were conducted and random effect model, one type of panel data, is used to analyze whether there is a relationship between corporate governance and firm performance. The conceptual framework for this study is a combinationan of approaches to agency, stakeholder and stewardship theory. Panel data is created as unbalanced data and random effect model is used.Accounting based performance measures of firms: return on asset, return on equity and returnon sales were used to compare with Saha’s Corporate Governance Rating Score based on four sub-indices: 1) shareholder rights, 2) public disclosure and transparency, 3) stakeholders and 4) board of directors. The results based on Saha’s Corporate Governance Score show that corporate governance does matter in Turkey. The study shows that better governed firms measured by high corporate governance score have better performance in Turkey. The result of regressing return on asset, return on equity against Saha’s corporate governance rating score indicates that there is a significantly relationship between corporate governance and firm performace. However, the result of regressing return on sales indicates that there is no statistically significant relation between Saha’s corporate governance score and return on sales.
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Ijaz, Maryum K. "The effect of SAHA on the expression of genes in wild type and Hdac2 knockout mouse models and its potential use as treatment for schizophrenia." VCU Scholars Compass, 2017. https://scholarscompass.vcu.edu/etd/5181.
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The symptoms of schizophrenia have been categorized into three subsets including positive, negative, and cognitive symptoms. Although atypical antipsychotic use has shown promising reduction in positive and negative symptoms of schizophrenia, such as hallucination, delusions and flat affect, the cognitive subset of symptoms remains and has an adverse impact on those affected. Chronic treatment with the atypical/secondary antipsychotic clozapine is one example that has ameliorated hallucinations and delusions but results in cognitive memory deficits. When chronically given in conjunction with the HDAC inhibitor, SAHA, the cognitive memory deficits of mouse models decline. HDAC2KO mice were bred and used in chronic treatments with either vehicle or SAHA and compared to WT mice, in order to analyze whether differential gene expression was occurring in an HDAC2 dependent manner. The expression of various genes involved in brain function were evaluated using RT-qPCR to determine potential differential regulation. The results showed differential expression of the following genes: Abhd16a, Gbf1, Itch, and Ube2g1. These genes are all involved in various neuronal functions.
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Capriotti, Giuseppe. "Classificazione spettrale delle stelle." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amslaurea.unibo.it/16375/.
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Tutte le nostre informazioni riguardo le proprietà fisiche delle stelle derivano più o meno direttamente dallo studio dei loro spettri, in particolare attraverso lo studio della variazione delle linee di assorbimento, della temperatura e della composizione. Dopo una rapida definizione di stella e di corpo nero, si passa alla descrizione delle classificazioni di Harvard, di Yerkes e del diagramma H-R. Infine si giunge allo studio degli spettri stellari e all'analisi e al comportamento delle righe di assorbimento che li caratterizzano.
Vengono quindi citate le importanti equazioni di Boltzmann e Saha. Infine si concentra l'attenzione su un peculiare caso astrofisico, le stelle di Wolf-Rayet.
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Saha, Bratati. "Identification and Validation of Small Molecules Inhibiting Human Adenovirus Replication." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39677.
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Human adenovirus (HAdV) mainly causes minor illnesses, but can lead to severe disease and death in both immunocompromised and immunocompetent patients. In such cases, the current standards of treatment often do not improve disease outcome and no approved antiviral therapy against HAdV exists. Since HAdV relies on cellular machinery to assist in the progression of the virus lifecycle, we hypothesized that small molecules targeting certain cellular proteins/pathways, without severely affecting cell health, may serve as effective anti-HAdV compounds. Thus, we aimed to identify novel inhibitors of HAdV, and investigate the molecular mechanism to determine new therapeutic targets for intervention in HAdV infection. We first examined the antiviral properties of pan-histone deacetylase (HDAC) inhibitor SAHA and found that the drug affects multiple stages of the HAdV lifecycle, resulting in significant reductions in virus yield. SAHA was effective in decreasing gene expression from clinically relevant HAdV serotypes. Subsequent investigations on the role of HDACs in HAdV infection led us to determine that class I HDAC activity, mainly HDAC2, is necessary for optimal viral gene expression. Using a wildtype-like HAdV reporter construct that allows us to monitor virus replication by fluorescence microscopy, we then designed an efficient system for screening small molecules to identify novel HAdV inhibitors. We screened over 1300 small molecules, and the screen was sensitive enough to detect compounds with both robust and modest antiviral activity. Several positive hits were validated to reduce HAdV gene expression and yield from infected cells. Further investigation on the efficacy of these compounds and the mechanism behind their inhibition of HAdV can lead to the discovery of new pharmacological targets and the development of more effective antivirals.
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Greiwe, Gillis [Verfasser], and Joachim [Akademischer Betreuer] Boos. "In-vitro-Effekte von SAHA, Tyrphostin AG 1478 und Carmustin an einem Panel von 18 pädiatrisch-onkologischen Zelllinien / Gillis Greiwe ; Betreuer: Joachim Boos." Münster : Universitäts- und Landesbibliothek Münster, 2014. http://d-nb.info/1138281980/34.
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Abhijit, Saha. "Chemical Biology Approaches for the Molecular Recognition of DNA Double Helix." 京都大学 (Kyoto University), 2015. http://hdl.handle.net/2433/199116.
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Couto, Isabel Amaral. "Método para deteção de 2,4,6-TCA por contaminação de gases halogenados de uma superfície emissora de iões positivos." Master's thesis, Faculdade de Ciências e Tecnologia, 2013. http://hdl.handle.net/10362/12201.
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Dissertação para obtenção do Grau de Mestre em
Engenharia FísicaA contaminação do vinho que produz cheiro a “mofo” é um problema que afeta a indústria corticeira. O principal agente contaminante é 2,4,6-TCA que, em solução alcoólica, o limiar de deteção humana é da ordem de 5 ng/L. As características da rolha de cortiça tornam difícil a sua descontaminação e os métodos de deteção disponíveis atualmente não permitem a aplicação na indústria. Neste trabalho, é explorada a deteção de gases halogenados pela formação de uma dupla camada na superfície de um emissor de iões alcalinos. Os iões alcalinos são emitidos por ionização superficial. A corrente iónica alcalina em vácuo segue, nas condições experimentais, a lei de Child-Langmuir e a função de trabalho é calculada num determinado intervalo de temperatura pela equação de Saha-Langmuir. Embora os resultados tenham tido um sucesso limitado, verificou-se que a introdução de clorofórmio (como exemplo de gás halogenado) produziu um aumento da corrente iónica que depende da temperatura e da pressão. A recuperação da corrente foi feita ao aquecer o emissor até cerca de 1200K durante alguns minutos. O campo eléctrico de extração que foi aplicado variou entre 30V/cm e 135V/cm em regime contínuo e a temperatura variou entre 800K e 1200K.
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Bunjongsiri, Kultida. "The Utility of Health and Safety Performance to examine the Eco - Industrial parks development: A case study of Saha Group industrial park Sriracha, Thailand." Thesis, Griffith University, 2017. http://hdl.handle.net/10072/370348.
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The Industrial Revolution of the 18th and 19th centuries brought the world significant technological and economic development, but also increasing energy consumption and pollution. The new factories around the world have become major users of both energy and virgin materials and producers of large amounts of hazardous waste and pollution. Although many countries have taken steps to address their environmental impacts through pollution prevention, cleaner production, and environmental management measures, industries at large still have not systematically addressed environmental issues either in the long term or in a comprehensive way. The concepts and philosophy of eco-industrial development (EID) have emerged as a useful approach to effectively manage pollution prevention and control towards sustainable development.
To realise EID, the Eco-Industrial Park (EIP), is a promising strategy to promote sustainable industrial development and to improve the industries’ environmental performance in terms of managing materials, energy and waste. The EIP concept has emerged from attempts to apply ecological principles to industrial activities and community design, and there have been many successful examples from the developed economies. However, the concept of an EIP has no universally accepted definition, and the term EIP may refer to many types of development projects. In fact, many EIP projects are already underway in different forms in various countries, including developing countries such as Thailand.Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
Griffith School of Engineering
Science, Environment, Engineering and Technology
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Abdullahi, Sahra [Verfasser], Hans [Akademischer Betreuer] Pretzsch, Thomas [Gutachter] Knoke, Hans [Gutachter] Pretzsch, and Mathias [Gutachter] Schardt. "Detection and definition of forest structure types by means of radar remote sensing (TanDEM-X) / Sahra Abdullahi ; Gutachter: Thomas Knoke, Hans Pretzsch, Mathias Schardt ; Betreuer: Hans Pretzsch." München : Universitätsbibliothek der TU München, 2018. http://d-nb.info/1187443867/34.
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