Journal articles: 'SALBP'

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Dou, Jianping, Jun Li, and Xia Zhao. "A novel discrete particle swarm algorithm for assembly line balancing problems." Assembly Automation 37, no. 4 (September 4, 2017): 452–63. http://dx.doi.org/10.1108/aa-08-2016-104.

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Purpose The purpose of this paper is to develop a feasible sequence-oriented new discrete particle swarm optimization (NDPSO) algorithm with novel particles’ updating mechanism for solving simple assembly line balancing problems (SALBPs). Design/methodology/approach In the NDPSO, a task-oriented representation is adopted to solve type I and type II SALBPs, and a particle directly represents a feasible task sequence (FTS) as a permutation. Then, the particle (permutation) is updated as a whole using the geometric crossover based on the edit distance with swaps for two permutations. Furthermore, the fragment mutation with adaptive mutation probability is incorporated into the NDPSO to improve exploration ability. Findings Case study illustrates the effectiveness of the NDPSO. Comparative results between the NDPSO and existing real-encoded PSO (CPSO) and direct discrete PSO (DDPSO) against benchmark instances of type I SALBP and type II SALBP show promising higher performance of the proposed NDPSO. Originality/value A novel particles’ updating mechanism for FTS-encoded particle is proposed to solve the SALBPs. The comparative results indicate that updating of FTS as a whole seems superior to existing updating of FTS by fragment with respect to exploration ability for solving SALBPs. The novel particles’ updating mechanism is also applicable to generalized assembly line balancing problems.

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Fathi, Masood, Dalila Benedita Machado Martins Fontes, Matias Urenda Moris, and Morteza Ghobakhloo. "Assembly line balancing problem." Journal of Modelling in Management 13, no. 2 (May 14, 2018): 455–74. http://dx.doi.org/10.1108/jm2-03-2017-0027.

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Purpose The purpose of this study is to first investigate the efficiency of the most commonly used performance measures for minimizing the number of workstations (NWs) in approaches addressing simple assembly line balancing problem (SALBP) for both straight and U-shaped line, and second to provide a comparative evaluation of 20 constructive heuristics to find solutions to the SALBP-1. Design/methodology/approach A total of 200 problems are solved by 20 different constructive heuristics for both straight and U-shaped assembly line. Moreover, several comparisons have been made to evaluate the performance of constructive heuristics. Findings Minimizing the smoothness index is not necessarily equivalent to minimizing the NWs; therefore, it should not be used as the fitness function in approaches addressing the SALBP-1. Line efficiency and the idle time are indeed reliable performance measures for minimizing the NWs. The most promising heuristics for straight and U-shaped line configurations for SALBP-1 are also ranked and introduced. Practical implications Results are expected to help scholars and industrial practitioners to better design effective solution methods for having the most balanced assembly line. This study will further help with choosing the most proper heuristic with regard to the problem specifications and line configuration. Originality/value There is limited research assessing the efficiency of the common objectives for SALBP-1. This study is among the first to prove that minimizing the workload smoothness is not equivalent to minimizing the NWs in SALBP-1 studies. This work is also one of the first attempts for evaluating the constructive heuristics for both straight and U-shaped line configurations.

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Zhang, Han-ye. "An immune genetic algorithm for simple assembly line balancing problem of type 1." Assembly Automation 39, no. 1 (February 4, 2019): 113–23. http://dx.doi.org/10.1108/aa-08-2017-101.

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Purpose The purpose of this study is to develop an immune genetic algorithm (IGA) to solve the simple assembly line balancing problem of type 1 (SALBP-1). The objective is to minimize the number of workstations and workstation load for a given cycle time of the assembly line. Design/methodology/approach This paper develops a new solution method for SALBP-1, and a user-defined function named ψ(·) is proposed to convert all the individuals to satisfy the precedence relationships during the operation of IGA. Findings Computational experiments suggest that the proposed method is efficient. Originality/value An IGA is proposed to solve the SALBP-1 for the first time.

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Zhang, Haijun, Qiong Yan, Yuanpeng Liu, and Zhiqiang Jiang. "An integer-coded differential evolution algorithm for simple assembly line balancing problem of type 2." Assembly Automation 36, no. 3 (August 1, 2016): 246–61. http://dx.doi.org/10.1108/aa-11-2015-089.

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Purpose This paper aims to develop a new differential evolution algorithm (DEA) for solving the simple assembly line balancing problem of type 2 (SALBP-2). Design/methodology/approach Novel approaches of mutation operator and crossover operator are presented. A self-adaptive double mutation scheme is implemented and an elitist strategy is used in the selection operator. Findings Test and comparison results show that the proposed IDEA obtains better results for SALBP-2. Originality/value The presented DEA is called the integer-coded differential evolution algorithm (IDEA), which can directly deal with integer variables of SALBP-2 on a discrete space without any posterior conversion. The proposed IDEA will be an alternative in evolutionary algorithms, especially for various integer/discrete-valued optimization problems.

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Arık, Oğuzhan Ahmet, Erkan Köse, and Jeffrey Forrest. "Simple assembly line balancing problem of Type 1 with grey demand and grey task durations." Grey Systems: Theory and Application 9, no. 4 (October 14, 2019): 401–14. http://dx.doi.org/10.1108/gs-05-2019-0011.

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Purpose The purpose of this paper is to present a mixed integer programming model for simple assembly line balancing problems (SALBP) with Type 1 when the annual demand and task durations are uncertain and encoded with grey numbers. Design/methodology/approach Grey theory and grey numbers are used for illustrating the uncertainty of parameters in an SALBP, where the objective is to minimize the total number of workstations. The paper proposes a 0-1 mathematical model for SALBP of Type 1 with grey demand and grey task durations. Findings The uncertainty of the demand and task durations are encoded with grey numbers and a well-known 0-1 mathematical model for SALBP of Type 1 is modified to find the minimum number of workstations in order to meet both the lower and upper bounds of the uncertain demand. The results obtained from the proposed mathematical model show a task-workstation assignment that does not distribute precedence relations among tasks and workstations and the sum of task durations in each single workstation is less than or equal to the grey cycle time. Originality/value The grey theory and grey numbers have not been previously used to identify uncertainties in assembly line balancing problems. Therefore, this study provides an important contribution to the literature.

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Zacharia, Paraskevi T., Sotirios A. Tsirkas, Georgios Kabouridis, Andreas Ch Yiannopoulos, and Georgios I. Giannopoulos. "Genetic-Based Optimization of the Manufacturing Process of a Robotic Arm under Fuzziness." Mathematical Problems in Engineering 2018 (December 24, 2018): 1–12. http://dx.doi.org/10.1155/2018/9168014.

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Fuzziness is a key concern in modern industry and, thus, its implementation in manufacturing process modeling is of high practical importance for a wide industrial audience. The scientific contribution of the present attempt lies on the fact that the assembly line balancing problem of type 2 (SALBP-2) is approached for a real manufacturing process by introducing fuzzy processing times. The main scope of this work is the solution of the SALBP-2, which is an NP-hard problem, for a real manufacturing process considering fuzziness in the processing times. Since the data obtained from realistic situations are imprecise and uncertain, the consideration of fuzziness for the solution of SALBP-2 is of great interest. Thus, real data values for the processing times are gathered and estimated with uncertainty. Then, fuzzy processing times are used for finding the optimum cycle time. The optimization tool for the solution of the fuzzy SALBP-2 is a Genetic Algorithm (GA). The validity of the proposed approach is tested on the construction process of a metallic robotic arm. The experimental results demonstrate the effectiveness and efficiency of the proposed GA in determining the optimum sequence of the tasks assigned to workstations which provides the optimum fuzzy cycle time.

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Jirasirilerd, Ganokgarn, Rapeepan Pitakaso, Kanchana Sethanan, Sasitorn Kaewman, Worapot Sirirak, and Monika Kosacka-Olejnik. "Simple Assembly Line Balancing Problem Type 2 By Variable Neighborhood Strategy Adaptive Search: A Case Study Garment Industry." Journal of Open Innovation: Technology, Market, and Complexity 6, no. 1 (March 18, 2020): 21. http://dx.doi.org/10.3390/joitmc6010021.

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This article aims to minimize cycle time for a simple assembly line balancing problem type 2 by presenting a variable neighborhood strategy adaptive search method (VaNSAS) in a case study of the garment industry considering the number and types of machines used in each workstation in a simple assembly line balancing problem type 2 (SALBP-2M). The variable neighborhood strategy adaptive search method (VaNSAS) is a new method that includes five main steps, which are (1) generate a set of tracks, (2) make all tracks operate in a specified black box, (3)operate the black box, (4) update the track, and (5) repeat the second to fourth steps until the termination condition is met. The proposed methods have been tested with two groups of test instances, which are datasets of (1) SALBP-2 and (2) SALBP-2M. The computational results show that the proposed methods outperform the best existing solution found by the LINGO modeling program. Therefore, the VaNSAS method provides a better solution and features a much lower computational time.

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Huo, Jiage, Zhengxu Wang, Felix T. S. Chan, Carman K. M. Lee, and Jan Ola Strandhagen. "Assembly Line Balancing Based on Beam Ant Colony Optimisation." Mathematical Problems in Engineering 2018 (October 3, 2018): 1–17. http://dx.doi.org/10.1155/2018/2481435.

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We use a hybrid approach which executes ant colony algorithm in combination with beam search (ACO-BS) to solve the Simple Assembly Line Balancing Problem (SALBP). The objective is to minimise the number of workstations for a given fixed cycle time, in order to improve the solution quality and speed up the searching process. The results of 269 benchmark instances show that 95.54% of the problems can reach their optimal solutions within 360 CPU time seconds. In addition, we choose order strength and time variability as indicators to measure the complexity of the SALBP instances and then generate 27 instances with a total of 400 tasks (the problem size being much larger than that of the largest benchmark instance) randomly, with the order strength at 0.2, 0.6 and 0.9 three levels and the time variability at 5-15, 65-75, and 135-145 levels. However, the processing times are generated following a unimodal or a bimodal distribution. The comparison results with solutions obtained by priority rule show that ACO-BS makes significant improvements on the quality of the best solutions.

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Grangeon, Nathalie, and Sylvie Norre. "Extending metaheuristics based on bin packing for SALBP to PALBP." European J. of Industrial Engineering 6, no. 6 (2012): 713. http://dx.doi.org/10.1504/ejie.2012.051073.

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Pastor, Rafael, Alberto García‐Villoria, and Albert Corominas. "Comparing ways of breaking symmetries in mathematical models for SALBP‐1." Assembly Automation 31, no. 4 (September 27, 2011): 385–87. http://dx.doi.org/10.1108/01445151111172970.

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Pitakaso, Rapeepan. "Differential evolution algorithm for simple assembly line balancing type 1 (SALBP-1)." Journal of Industrial and Production Engineering 32, no. 2 (February 17, 2015): 104–14. http://dx.doi.org/10.1080/21681015.2015.1007094.

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Dolgui, Alexandre, and Evgeny Gafarov. "Can a Branch and Bound algorithm solve all instances of SALBP-1 efficiently?" IFAC-PapersOnLine 52, no. 13 (2019): 2788–91. http://dx.doi.org/10.1016/j.ifacol.2019.11.630.

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Zheng, Qiao Xian, Yuan Xiang Li, Ming Li, and Qiu Hua Tang. "An Improved Ant Colony Optimization for Large-Scale Simple Assembly Line Balancing Problem of Type-1." Applied Mechanics and Materials 159 (March 2012): 51–55. http://dx.doi.org/10.4028/www.scientific.net/amm.159.51.

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An improvement ant colony optimization(ACO) is proposed to solve the simple assembly line balancing problem of type-1 (SALBP-1) which aims to minimize the number of workstations for a given cycle time of assembly line. In the algorithm, three heuristic factors and two pheromones: (1) the pheromone between task and station, (2) the pheromone among tasks, are introduced to design the selection mechanism which is used to select task for station. The task assignment mechanism is proposed to assign suitable tasks to station. Ants select task based on selection mechanism, and then assign suitable one to station according to assignment mechanism. The result of literature test problems indicates the effectiveness of the proposed algorithm.

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Silva Júnior, Ormeu Coelho da, Gilberto de Miranda Júnior, and Samuel Vieira Conceição. "Reconfiguração dinâmica de linhas de montagem." Pesquisa Operacional 30, no. 1 (April 2010): 237–58. http://dx.doi.org/10.1590/s0101-74382010000100012.

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Neste trabalho se propõe um novo problema envolvendo linhas de montagem. Nele se considera a necessidade de reconfiguração devido à mudança no tempo de ciclo requerido. Para tratá-lo, foram propostos quatro modelos de programação inteira mista, sendo três deles baseados em um horizonte de planejamento discretizado em períodos, o que dá ao problema um caráter dinâmico. Simultaneamente, força-se a suavização da carga de trabalho entre as estações, limitando-a com valores mínimos e máximos. Os modelos foram implementados em um pacote comercial de programação matemática e os resultados de alguns testes preliminares são reportados. Comparações entre o uso sucessivo de abordagens clássicas (tipo SALBP) e a modelagem dinâmica demonstram a superioridade da abordagem proposta.

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., Parudh Mahajan. "BALANCING THE LINE BY USING HEURISTIC METHOD BASED ON CPM IN SALBP –A CASE STUDY." International Journal of Research in Engineering and Technology 04, no. 12 (December 25, 2015): 76–80. http://dx.doi.org/10.15623/ijret.2015.0412016.

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Kamarudin, N. H., and M. F. F. Ab. Rashid. "Modelling of Simple Assembly Line Balancing Problem Type 1 (SALBP-1) with Machine and Worker Constraints." Journal of Physics: Conference Series 1049 (July 2018): 012037. http://dx.doi.org/10.1088/1742-6596/1049/1/012037.

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Edokpia, Ralph O., and F. U. Owu. "Assembly Line Re-Balancing Using Ranked Positional Weight Technique and Longest Operating Time Technique: A Comparative Analysis." Advanced Materials Research 824 (September 2013): 568–78. http://dx.doi.org/10.4028/www.scientific.net/amr.824.568.

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Assembly line balancing is an attractive means of mass manufacturing and large-scale serial production systems. Traditionally, assembly lines are arranged in straight single-model lines and the problem is known as Simple Assembly Line balancing problem (SALBP). In this study, two heuristic assembly line balancing techniques known as the Ranked Positional Weight Technique, and the longest operational time technique, were applied to solve the problem of single-model line balancing problem in an assembling company with the aim of comparing the efficiencies of the application of the two algorithms. By using both methods, different restrictions were taken into consideration and two different lines balancing results were obtained. From the results obtained, Longest Operating Time Technique has higher line efficiency (85.16%) as compared to Ranked positional weight technique (79.28%) and it is easy to apply. The LOT technique gave the minimum number of workstations (27) as compared to the RPW technique (29); however the line efficiency and the number of workstation of the existing line are 74.67% and 31 respectively. This implies that the LOT technique has a better reduction in operating cost.

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Álvarez-Miranda, Eduardo, Jordi Pereira, Harold Torrez-Meruvia, and Mariona Vilà. "A Hybrid Genetic Algorithm for the Simple Assembly Line Balancing Problem with a Fixed Number of Workstations." Mathematics 9, no. 17 (September 4, 2021): 2157. http://dx.doi.org/10.3390/math9172157.

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The assembly line balancing problem is a classical optimisation problem whose objective is to assign each production task to one of the stations on the assembly line so that the total efficiency of the line is maximized. This study proposes a novel hybrid method to solve the simple version of the problem in which the number of stations is fixed, a problem known as SALBP-2. The hybrid differs from previous approaches by encoding individuals of a genetic algorithm as instances of a modified problem that contains only a subset of the solutions to the original formulation. These individuals are decoded to feasible solutions of the original problem during fitness evaluation in which the resolution of the modified problem is conducted using a dynamic programming based approach that uses new bounds to reduce its state space. Computational experiments show the efficiency of the method as it is able to obtain several new best-known solutions for some of the benchmark instances used in the literature for comparison purposes.

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Ma, X. "Finding the best possible solutions to simple assembly line balancing problems." Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture 211, no. 1 (January 1, 1997): 53–61. http://dx.doi.org/10.1243/0954405971516077.

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Assembly line balancing (ALB) is an important aspect in the design of many flow line type manufacturing systems which may or may not be assembly oriented. It involves essentially assigning individual tasks into stations such that certain constraints are satisfied and some specified objectives achieved. Although this problem has attracted a great deal of research effort over the past forty years, it still remains unsolved. This paper presents a computer-based method for the simple assembly line balancing problem (SALBP). For a given problem, the method makes use of some efficient and systematic search and identification techniques to establish task trees for individual stations and to develop a station tree for multiple solutions. Different from all known existing assembly line balancing methods, this method aims at finding the best possible solutions that lead to the maximum production rate and the minimum station workload variation. The essential and distinct concepts adopted by the method are described in this paper, along with its step-by-step execution procedure and an illustrative example. Since the method does not involve difficult mathematics, many industrial practitioners can easily understand it and appreciate its effectiveness.

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Chen, Jie, and Jiangnan Hu. "The Influencing Factor Analysis on the Performance Evaluation of Assembly Line Balancing Problem Level 1 (SALBP-1) Based on ANOVA Method." IOP Conference Series: Materials Science and Engineering 212 (June 2017): 012008. http://dx.doi.org/10.1088/1757-899x/212/1/012008.

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Le, T. H., Anh-Luan Phan, Nguyen Minh Ty, Dacheng Zhou, Jianbei Qiu, and Ho Kim Dan. "Influences of copper–potassium ion exchange process on the optical bandgaps and spectroscopic properties of Cr3+/Yb3+ co-doped in lanthanum aluminosilicate glasses." RSC Advances 11, no. 15 (2021): 8917–26. http://dx.doi.org/10.1039/d0ra10831f.

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Fauziah, Fauziah, Siti Arum Widiyanti, Rinaldi Rinaldi, and Ernita Silviana. "Formulasi dan Uji Stabilitas Fisik Sediaan Salep Dari Ekstrak Etanol Daun Pare (Momordica Charantia L) Sebagai Obat Luka." Journal of Pharmaceutical And Sciences 2, no. 1 (July 31, 2019): 45–51. http://dx.doi.org/10.36490/journal-jps.com.v2i1.19.

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Daun pare mengandung senyawa metabolit sekunder seperti flavonoid, tanin, saponin, steroid, alkaloid, dan terpenoid yang dapat menghambat pertumbuhan bakteri. Daun pare dapat dimanfaatkan sebagai obat, salah satunya yaitu untuk mengobati luka karena mempunyai daya hambat bakteri dan dapat menutup luka. Penelitian ini bertujuan untuk mengetahui pengaruh basis terhadap stabilitas salep dan untuk mengetahui formulasi mana yang memenuhi syarat stabilitas sediaan salep. Jenis penelitian ini ialah eksperimental. Dasar salep yang digunakan yaitu dasar salep hidrokarbon dan dasar salep serap. Penyarian ekstrak daun pare dilakukan dengan cara maserasi menggunakan pelarut etanol 70%. Salep ekstrak etanol daun pare dibuat sebanyak 3 formula dengan menggunakan basis yang sama dan konsentrasi ekstrak yang bebeda. Pembuatan sediaan salep menggunakan metode peleburan. Evaluasi sediaan salep dilakukan dengan uji organoleptik, uji homogenitas, uji pengukuran pH dan uji daya sebar. Hasil pengujian semua sediaan salep dari formula I, formula II dan formula III memenuhi parameter kualitas uji organoleptis, homogenitas dan uji pH. Untuk pengujian daya sebar pada masing-masing formula hanya formula I yang mendekati parameter uji stabilitas fisik.

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Yamlean, Paulina Veronika, Edwin De Queljoe, and Widdhi Bodhi. "Variasi Basis Salep Minyak Kemiri (Aleurites moluccana) dan Uji Daya Penyembuhannya Pada Luka Kelinci." JURNAL ILMU KEFARMASIAN INDONESIA 17, no. 2 (October 29, 2019): 232. http://dx.doi.org/10.35814/jifi.v17i2.647.

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Kemiri di Indonesia masih terbatas penggunaannyasecara tradisional seperti bumbu masak dan obat tradisional. Penelitian tentang minyak Kemiri belum banyak dilakukan.Tujuan penelitian ini ialah membuat variasi Basis Salep terhadap mutu sediaan salep minyak Kemiri 12,5% dan Uji daya penyembuhannya terhadap luka terbuka pada kelinci yang terinfeksi bakteri Staphylococcus aureus. Metode penelitian ini ialah eksperimen laboratorium menggunakan 3 variasi basis salep yaitu basis hidrokarbon, basis absorpsi dan basis larut air dengan larutan uji minyak Kemiri 12,5%. Hasil penelitian menunjukkan uji mutu salep dengan tiga variasi basis salep memenuhi syarat uji organoleptik, uji homogenitas, dan uji pH, tetapi Salep minyak Kemiri 12,5% dengan basis hidrokarbon tidak memenuhi syarat daya sebar. Hasil uji Anova menunjukan tidak ada perbedaan signifikan antara variasi basis salep dan besar luka penyembuhan. Hal ini menunjukan bahwa ketiga variasi basis salep minyak Kemiri 12,5% dapat digunakan dalam penyembuhan luka terbuka pada kelinci (Oryctolagus cuniculus) yang terinfeksi bakteri Staphylococcus aureus.

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Cahyadi, Martin Aristo, Boy Rahardjo Sidharta, and Nelsiani To'bungan. "Karakteristik dan Efektivitas Salep Madu Klanceng dari Lebah Trigona sp. Sebagai Antibakteri dan Penyembuh Luka Sayat." Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati 4, no. 3 (November 8, 2019): 104. http://dx.doi.org/10.24002/biota.v4i3.2520.

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Penggunaan antibiotik secara terus menerus dapat menimbulkan resistensi pada bakteri. Salah satu bahan alami yang dapat menjadi alternatif pengobatan adalah madu klanceng. Penelitian ini bertujuan untuk mengetahui sediaan salep madu klanceng yang optimal dan efeknya terhadap penyembuhan luka dan infeksi yang disebabkan oleh bakteri. Tahapan penelitian ini terdiri dari uji fitokimia madu, pembuatan salep, uji sediaan salep, uji kemurnian bakteri, uji zona hambat, dan uji bioassay pada kelinci. Madu klanceng yang diuji mengandung senyawa alkaloid. Variasi salep madu dibuat dengan perbandingan basis salep dan madu adalah 1:1, 1:2, 1:5, dan 5:1. Hasil salep berbentuk semi padat, berwarna kuning, pH sekitar 4,8, belum homogen, memiliki daya lekat sekitar 265,4 detik, dan daya sebar sebesar 1,76 cm. Salep madu mampu menghambat bakteri S. aureus dan P. aeruginosa dengan diameter sebesar 1,2 mm. Salep madu ini juga memberikan efek menyembuhkan luka hingga 0,3 cm.

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., Emilia. "EFEKTIFITAS PEMBERIAN SALEP KULIT GENTAMICYN TERHADAP PENYEMBUHAN LUKA PADA PASIEN DIABETES MELLITUS DI WILAYAH KERJA PUSKESMAS BERINGIN RAYA KOTA BENGKULU TAHUN 2018." Journal of Nursing and Public Health 7, no. 1 (May 17, 2019): 17–24. http://dx.doi.org/10.37676/jnph.v7i1.757.

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Pasien Infeksi ulkus kaki diabetik memerlukan penggunaan salep kulit gentamicyn, salep kulit gentamicyn yang sering digunakan mempunyai sensitifitas rendah dan beberapa pasien pada penggunaannya dalam keadaan resistensi, evaluasi efektifitas salep kulit gentamicyn perlu dilakukan untuk mengatasi masalah luka Diabetik grade I dan II saat ini agar tidak berlanjut ke grade berikutnya. Penelitian ini dilakukan dengan studi longitudinal dan teknik pengambilan sampel secara prospektif. Paramater yang diamati adalah keadaan leukosit, tanda infeksi dan demam seteleh pemberian salep kulit gentamicyn. Data yang terkumpul kemudian dianalisis secara deskriptif untuk menentukan efektifitas salep kulit gentamicyn berdasarkan literatur yang mendukung. Hasil perolehan sampel pada penelitian ini adalah sebanyak 19 sampel pasien infeksi ulkus kaki diabetik yang memenuhi kriteria dari 28 orang populasi terdiri dari 63,16% pasien laki-laki dan 36,84% pasien perempuan, 68,42 % usia 45-60 tahun dan lama diabetes terbanyak adalah > 10 tahun. Hasil evaluasi efektifitas salep kulit gentamicyn yaitu ditemukan 8 orang pasien yang menggunakan salep kulit gentamicyn secara dugaan (empiris) dan 11 orang pasien menggunakan salep kulit gentamicyn berdasarkan sensitifitas (definitif). salep kulit gentamicyn efektif pada 15 orang subjek penelitian yaitu dapat memberikan respon pada leukosit, tanda infeksi dan parameter demam seteleh pemberian salep kulit gentamicyn 2-3 hari dan hasil terapi maksimal pada hari ke 7 sampai 21.

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Dhego, Anastasia P., Lina Susanti, and D. Andang Arif Wibawa. "Uji Aktivitas Antibakteri Salep Ekstrak Kulit Batang Kesambi (Schleichera oleosa Merr) terhadap Staphylococcus aureus ATCC 25923 yang Diinfeksikan pada Kelinci." Biomedika 10, no. 2 (March 5, 2018): 11–17. http://dx.doi.org/10.31001/biomedika.v10i2.270.

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Tujuan penelitian ini adalah untuk mengetahui aktivitas antibakteri salep ekstrak etanolik kulit batang kesambi (Scheichera oleosa Merr.) dan konsentrasi yang efektif dari salep ekstraknya pada kulit punggung kelinci yang terinfeksi Staphylococcus aureus ATCC 25923. Ekstraksi dilakukan secara maserasi menggunakan pelarut etanol 70%. Formula salep ekstrak kulit batang kesambi dibuat dengan basis hidrokarbon dengan tiga konsentrasi yaitu 6,25%, 12,5% dan 25% dengan salep Gentamicin sebagai kontrol positif. Pengamatan waktu penyembuhan dilakukan dengan cara mengamati lamanya penyembuhan infeksi pada kulit punggung kelinci setelah pemberian salep ekstrak kulit batang kesambi yang ditandai dengan hilangnya eritema dan nanah. Data yang diperoleh dianalisis dengan ANOVA satu jalan (signifikansi p<0,05). Hasil dari penelitian menunjukan bahwa salep ekstrak kulit batang kesambi memiliki efektivitas pada penyembuhan infeksi bakteri Staphylococcus aureus dan terdapat perbedaan efektivitas pada setiap konsentrasi. Konsentrasi salep ekstrak kulit batang kesambi 25% memberikan efek penyembuhan yang lebih efektif dibandingkan dengan konsentrasi 12,5% dan 6,25%.

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Pertiwi, Reza, Syalfinaf Manaf, Rochmah Supriati, Hari Marta Saputra, and Fitri Ramadhanti. "Pengaruh Pemberian Salep Kombinasi Ekstrak Daun Morinda citrifolia dan Batang Euphorbia tirucalli terhadap Penyembuhan Luka." JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA 7, no. 1 (June 25, 2020): 42. http://dx.doi.org/10.20473/jfiki.v7i12020.42-50.

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Pendahuluan: Penyembuhan luka adalah proses terjadinya penggantian jaringan yang rusak atau mati dengan jaringan yang baru melalui proses regenarasi sel. Ranting Euphorbia tirucalli mengandung alkaloid, flavonoid, saponin, dan tannin, sedangkan Morinda citrifolia memiliki kandungan alkaloid, tanin, saponin, flavonoid serta triterpenoid. Kemampuan kandungan dari kombinasi salep ekstrak daun Morinda citrifolia dan batang Euphorbia tirucalli diduga dapat mempercepat penyembuhan luka dan periode fibroblas, neovaskularisasi dan epitelisasi. Tujuan: Penelitian ini bertujuan untuk mengetahui formulasi salep yang efektif dan pengaruh salep kombinasi ekstrak daun Morinda citrifolia dan batang Euphorbia tirucalli terhadap penyembuhan luka insisi dangkal pada tikus. Metode: Sebanyak 28 ekor tikus jantan dibagi kedalam 7 kelompok perlakuan. Kelompok K(-) tanpa perlakuan, kelompok K(+) dengan pemberian Povidon Iodine 10%, F1 dengan pemberian salep kombinasi ekstrak batang Euphorbia tirucalli, F2 dengan pemberian salep ektrak daun Morinda citrifolia, F3 dengan pemberian salep kombinasi ekstrak daun Morinda citrifolia dan batang Euphorbia tirucalli perbandingan 0,75:0,25; F4 dengan pemberian salep kombinasi ekstrak daun Morinda citrifolia dan batang Euphorbia tirucalli dengan perbandingan 1:1 dan F5 dengan pemberian salep kombinasi ekstrak daun Morinda citrifolia dan batang Euphorbia tirucalli perbandingan 0,25:0,75. Pengamatan histopatologi kulit tikus dianalisis secara deskriptif dengan membandingkan antara kelompok kontrol dan kelompok perlakuan. Hasil: Formulasi salep yang efektif adalah formulasi III dimana hari ke-5 dan hari ke-6 luka sudah mulai menutup sedangkan pada hari ke-7 dan 8 luka sudah menutup. Kesimpulan: Pemberian salep kombinasi daun Morinda citrifolia dan batang Euphorbia tirucalli efektif dalam menyembuhkan luka insisi dangkal melalui fase inflamasi, TNF-α, re-vaskularisasi dan fase proliferasi.

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Rezanejade Bardajee, Ghasem, and Zari Hooshyar. "CdTe Quantum Dots Embedded in Multidentate Biopolymer Based on Salep: Characterization and Optical Properties." Journal of Chemistry 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/202061.

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This paper describes a novel method for surface modification of water soluble CdTe quantum dots (QDs) by using poly(acrylic acid) grafted onto salep (salep-g-PAA) as a biopolymer. As-prepared CdTe-salep-g-PAA QDs were characterized by Fourier transform infrared (FT-IR) spectrum, thermogravimetric (TG) analysis, and transmission electron microscopy (TEM). The absorption and fluorescence emission spectra were measured to investigate the effect of salep-g-PAA biopolymer on the optical properties of CdTe QDs. The results showed that the optical properties of CdTe QDs were significantly enhanced by using salep-g-PAA-based biopolymer.

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Novita, Rita, Munira Munira, and Rima Hayati. "Formulasi Sediaan Salep Ekstrak Etanol Pliek U Sebagai Antibakteri." AcTion: Aceh Nutrition Journal 2, no. 2 (November 3, 2017): 103. http://dx.doi.org/10.30867/action.v2i2.62.

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Infeksi merupakan penyakit yang dapat ditularkan dari satu orang ke orang lain atau dari hewan ke manusia. Penyebab infeksi disebabkan oleh bakteri atau mikroorganisme yang patogen, salah satunya adalah Staphylococus aureus. Berdasar penelitian sebelumnya Pliek U memiliki aktivitas antibakteri karena mengandung bakteriosin pada konsentrasi 5 mg/mL. Salep merupakan sediaan setengah padat yang ditujukan untuk pemakaian topikal pada kulit atau selaput lendir. Penelitian ini bersifat ekperimental laboratorium. Rancangan percobaan yang akan digunakan adalah rancangan acak lengkap (RAL) dengan 3 perlakuan dan 3 kali pengulangan yang terdiri dari P0 : Formulasi basis salep, P1 ekstrak Pliek U dengan kosentrasi 5 mg/mL, dan P2: formulasi sediaan salep ekstrak Pliek U dengan kosentrasi 5 mg/mL. Salep yang digunakan dievaluasi organoleptis, homogenitas, daya sebar, pH dan uji mikrobiologi. Hasil uji sediaan salep dengan konsentrasi 5 mg/mL memenuhi hasil uji evaluasi organoleptik, homogenitas, daya sebar dan pH. Hasil uji mikrobiologi formulasi sediaan salep ekstrak Pliek U 5 mg/mL memiliki aktivitas antibakteri terhadap pertumbuhan bakteri Staphylococcus aureus. Kata kunci: Pliek U, Staphylococus aureus, Antibakteri, Salep

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Wijayantini, Rini, Ratna Cahyaningsih, and Andinny Nur Permatasari. "EFEKTIVITAS SALEP EKSTRAK ETANOL 70% DAUN PANDAN WANGI TERHADAP PENYEMBUHAN LUKA BAKAR PADA MENCIT PUTIH JANTAN." FITOFARMAKA: Jurnal Ilmiah Farmasi 8, no. 1 (May 30, 2019): 30–38. http://dx.doi.org/10.33751/jf.v8i1.1169.

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Luka bakar adalah kerusakan jaringan yang disebabkan kontak dengan sumber panas. Penelitian ini bertujuan untuk mengetahui pengaruh salep ekstrak etanol 70% daun pandan wangi terhadap penyembuhan luka bakar pada mencit putih jantan. Hewan coba yang digunakan adalah 28 ekor mencit putih jantan, berumur 2-3 bulan dengan bobot 25-40 g. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) pola faktorial dengan 7 kelompok perlakuan, masing-masing perlakuan terdiri dari 4 ekor mencit. Luka bakar derajat II dibuat pada punggung mencit dengan menempelkan logam berukuran 1 cm yang telah dipanaskan selama 5 menit pada suhu 980 C dan ditempelkan selama 10 detik. Perawatan dilakukan sehari sekali selama 16 hari terhadap kelompok P1 (Kelompok yang dilukai dan tanpa diberikan perlakuan apapun), P2 (hanya diberi basis salep), P3 (hanya diberi ekstrak 5% tanpa basis), P4 (diberi bioplacenton sebagai kontrol positif), P5 (diberi salep ekstrak 5%), P6 (salep ekstrak 7,5%) dan P7 (Salep Ekstrak 10%). Hasil penelitian menunjukkan bahwa perlakuan dengan salep ekstrak 5% (P5), 7,5% (P6) dan 10% (P7) memberikan pengaruh positif terhadap penyembuhan luka bakar pada mencit. Perlakuan salep ekstrak 10% (P7) paling optimal dalam mempercepat penyembuhan luka bakar dilihat dari jangka waktu penyembuhan pada hari ke 13 luka sudah sembuh dibandingkan perlakuan pada kelompok lainnya. Dapat disimpulkan bahwa salep ekstrak pandanwangi 10% memiliki potensi sebagai obat luka bakar.

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Gök, İsmail, Birol Kılıç, and Cem Okan Özer. "Salep Kullanımının Fermente Türk Sucuğu Kalite Parametreleri Üzerine Etkisi." Turkish Journal of Agriculture - Food Science and Technology 6, no. 2 (March 5, 2018): 219. http://dx.doi.org/10.24925/turjaf.v6i2.219-225.1593.

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The aim of this study, the effect of addition to salep at different concentrations (2.5, 5, 7.5 and 10%) into sucuk on physicochemical, textural and sensorial properties were investigated at d fermentation and storage periods (5., 10., 20. ve 30. days). The results indicated that TBARS values gradually increased during fermentation and storage periods in all treatment groups. However, addition of 10% salep decreased TBARS values compared to control group at the end of fermentation and storage period. pH values of sucuks were decreased with addition of salep. Higher L* values were observed in sucuk with 10% salep at the end of the fermentation and storage period. Increasing levels of salep in sucuk formulation caused an increase in hardness and ash values, a decrease in moisture values in sucuk. The results of this study indicated that salep may be used in sucuk manufacture by the meat industry to improve shelf-life and quality parameters of the product.

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Singh, Longjam Jaideva, and Rajkumar Hemakumar Singh. "Synthesis and Characterization of Heteronuclear Copper(II)-Lanthanide(III) Complexes of N,N′-1,3-Propylenebis(Salicylaldiminato) Where Lanthanide(III) = Gd or Eu." International Journal of Inorganic Chemistry 2013 (May 28, 2013): 1–9. http://dx.doi.org/10.1155/2013/281270.

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Three complexes, namely, [Cu(salbn)] (1), [Cu(salbn)Gd(NO3)3·H2O] (2), and [Cu(salbn)Eu(NO3)3·H2O] (3) where salbn = N,N′-1,3-propylenebis (salicylaldiminato) have been synthesized and characterized by elemental analyses, ICP-AES, IR, UV, NMR, MS, EDX, powder XRD, and EPR spectroscopies. The EDX results suggest the presence of two different metal ions in heteronuclear complexes (2) and (3). The ligand(salbn), complex (1), and complex (3) crystallize in triclinic system while complex (2) crystallizes in monoclinic system. The EPR studies suggest that [Cu(salbn)] complex is tetragonally coordinated monomeric copper(II) complex with unpaired electron in the dx2-y2 orbital and spectral features that are the characteristics of axial symmetry while complex (2) in DMF solution at liquid nitrogen temperature exhibits an anisotropic broad signal around g ~ 2.03 which may suggest a weak magnetic spin-exchange interaction between Gd(III) and Cu(II) ions. The fluorescence intensity of Eu(III) decreased markedly in the complex (3).

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Laut, Meity Marviana, Nemay Ndaong, Tri Utami, Maria Junersi, and Yovita Bria Seran. "EFEKTIVITAS PEMBERIAN SALEP EKSTRAK ETANOL DAUN ANTING – ANTING (Acalypha indica Linn.) TERHADAP KESEMBUHAN LUKA INSISI PADA MENCIT (Mus musculus)." JURNAL KAJIAN VETERINER 7, no. 1 (June 11, 2019): 1–11. http://dx.doi.org/10.35508/jkv.v7i1.377.

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Regenerasi dan pemulihan jaringan luka merupakan proses fisiologi normal tubuh dalam merespon perlukaan untuk mengembalikan integritas dan fungsi normal kulit. Kesembuhan luka dapat dipercepat dengan pemberian obat kimia maupun obat alami. Salep betadine 10% adalah obat kimia yang sering digunakan dalam perawatan luka untuk menstimulasi penyembuhan luka. Sedangkan, tanaman anting – anting (Acalypha indica) diketahui memiliki aktivitas antiinflamasi, antibakteri, antioksidan, dan antiulser. Daun anting – anting telah lama digunakan oleh masyarakat lokal di NTT untuk mengobati luka dan gangguan kulit lainnya pada ternak peliharaannya. Penelitian ini bertujuan untuk mengetahui gambaran makroskopik dan jumlah fibroblas pada kesembuhan luka insisi pada mencit yang diberi terapi salep ekstrak etanol daun anting – anting (EEDAA), sekaligus sebagai bukti empiris fitofarmaka ini bagi masyarakat lokal di NTT. Penelitian ini bersifat eksperimental laboratorik, menggunakan 30 ekor mencit jantan sehat, berumur 3-4 bulan dengan berat badan berkisar 30-40g. Mencit dibagi dalam 5 kelompok yaitu kelompok kontrol negatif (KN) dan positif (KP) yang masing – masing diaplikasikan basis salep vaselin album dan salep betadine 10%; serta tiga kelompok perlakuan yang masing – masing diberikan salep EEDAA konsentrasi 5%, 10% dan 20%. Setiap kelompok dibuat luka sayat pada area dorsum, dengan ukuran panjang 1.5 cm dengan kedalaman 2 mm. Bahan topikal diberikan sebanyak 2 kali/hari. Pengampilan sampel jaringan luka dilakukan pada hari ke-3, ke-7 dan ke-14. Hasil penelitian menunjukkan bahwa pemberian salep EEDAA konsentrasi 10% menunjukkan kesembuhan luka yang lebih cepat dan optimal dibandingkan dengan salep betadine 10%, salep EEDAA 5% dan 20%.

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Rahmadini, Nur Rifka, Sabaniah Indjar Gama, and Rolan Rusli. "Formulasi Sediaan Salep Ekstrak Kulit Batang Cadamba (Anthocephalus cadamba Miq.) dan Aktivitas Antibakterinya Terhadap Staphylococcus aureus." Proceeding of Mulawarman Pharmaceuticals Conferences 8 (December 31, 2018): 308–13. http://dx.doi.org/10.25026/mpc.v8i1.340.

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Cadamba (Anthocephalus cadamba Miq.) merupakan tanaman cepat tumbuh dengan banyak kegunaan. Metabolit sekunder yang terkandung dalam tanaman cadamba seperti alkaloid, flavonoid dan glikosida yang memiliki aktivitas antibakteri. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri ekstrak kulit batang cadamba dan sediaan salep berbahan aktif ekstrak cadamba. Hasil yang didapatkan menunjukkan bahwa ekstrak cadamba memiliki aktivitas antibakteri dengan konsentrasi efektif sebesar 5%. Sediaan salep dengan bahan aktif ekstrak cadamba memiliki pula aktivitas antibaketeri. Sediaan salep berbahan aktif ekstrak cadamba memenuhi persyaratan standar untuk sediaan salep, yang meliputi organoleptis, daya sebar, pH, dan homogenitas.

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Bawotong, Repatri A., Edwin De Queljoe, and Deby A. Mpila. "UJI EFEKTIVITAS SALEP EKSTRAK DAUN JARAK PAGAR (Jatropha curcas L.) TERHADAP PENYEMBUHAN LUKA SAYAT PADA TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus)." PHARMACON 9, no. 2 (May 28, 2020): 284. http://dx.doi.org/10.35799/pha.9.2020.29283.

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ABSTRACTJatropha leaves (Jatropha curcas L.) contains alkaloid, saponin, tannin, terpenoid, steroid, glycoside, phenol compound and flavonoid through ethanol extract. Until today the community still used the plant as a wound healing medicine. The aim of this study is to examine the effectiveness of jatropha curcas L. leaf extract ointment for healing in male white rats wistar strain. Jatropha leaves extract ointment was tested on 5 which consists of 3 rats in each treatment groups, that is base ointment (negative control), ointment betadine (positive control), ointment extract of Jatropha leaves 10%, 20% and 40%. Observations has made until the 14th day. And data were tested using ANOVA (Analysis of Variants) and continued with LSD (Least Significant Different) test. Statistical test results showed a difference in the duration of wound healing in male white rats wistar strain between the ointment extract of jatropha leaf with ointment betadine and vaseline ointment. Keywords: Ointment, Jatropha extract (Jatropha curcas L.), Galur wistar, Wound.ABSTRAK Daun jarak pagar (Jatropha curcas L.) mengandung zat-zat alkaloid, saponin, tannin, terpenoid, steroid, glikosida, senyawa fenol dan flavonoid melalui ekstrak etanol. Hingga saat ini masyarakat masih menggunakan tanaman tersebut sebagai obat penyembuh luka. Penelitian ini bertujuan untuk menguji efektivitas salep ekstrak etanol daun jarak pagar terhadap penyembuhan luka sayat pada tikus putih jantan galur wistar. Salep ekstrak daun jarak pagar diujikan pada hewan uji tikus sebanyak 5 yang terdiri dari 3 ekor tikus disetiap kelompok perlakuan, yaitu basis salep (kontrol negatif), salep betadine (kontrol positif), salep ekstrak etanol daun jarak pagar 10%, 20% dan 40%. Pengamatan dilakukan sampai hari ke 14. Data diuji dengan menggunakan ANOVA (Analisis Of Variant) dan dilanjutkan dengan uji LSD (Least Significant Different). Hasil uji statistik menunjukan adanya perbedaan terhadap lamanya penyembuhan luka pada tikus putih jantan galur wistar antara sediaan salep ekstrak daun jarak pagar dengan salep salep betadine dan basis salep. Kata Kunci: Salep, Daun jarak pagar (Jatropha curcas L.), Galur wistar, Luka sayat.

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Suwenita, Suwenita, Muhammad In'am Ilmiawan, and Sari Eka Pratiwi. "Efek Ekstrak Etanol 70% Daun Karamunting(Rhodomyrtus tomentos (Ait.) Hassk) Topikal terhadap Pertumbuhan Jumlah Sel Fibroblas Luka Insisi Kulit Tikus Putih Jantan Galur Wistar." Jurnal Cerebellum 5, no. 4B (November 1, 2019): 1583. http://dx.doi.org/10.26418/jc.v5i4b.44823.

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Latar Belakang. Luka adalah kerusakan fisik sebagai akibat dari terbukanya atau hancurnya kulit yang menyebabkan gangguan fungsi dan anatomi kulit normal yang disebabkan oleh mikroba, trauma mekanik, kimia, atau suhu yang mengenai jaringan. Sejumlah studi menunjukkan bahwa tanaman tradisional potensial sebagai agen penyembuhan luka, salah satunya daun karamunting (Rhodomyrtus tomentosa (Aiton) Hassk). Metode. Penelitian ini adalah penelitian eksperimental dengan rancangan posttest only control group design. Subjek penelitian adalah 25 ekor tikus Wistar jantan yang dibagi menjadi lima kelompok, yaitu kelompok kontrol positif (salep sanoskin®), kelompok kontrol negatif (salep plasebo), kelompok perlakuan 1 (salep ekstrak daun karamunting 2,5%), kelompok perlakuan 2 (salep ekstrak daun karamunting 5%) dan kelompok perlakuan 3 (salep ekstrak daun karamunting 10%). Masing-masing kelompok terdiri dari lima ekor tikus. Pada setiap kelompok dilakukan insisi di punggung sepanjang 2 cm dengan kedalaman 0,2 cm sejajar os.vertebrae, berjarak 5 cm dari telinga. Pada hari kesepuluh dilakukan pengambilan jaringan luka dan pembuat preparat histologi dengan pewarnaan H&E dan diamati sel fibroblas pada perbesaran lensa objektif 40x. Data dianalisa menggunakan uji one-way anova dilanjutkan dengan post hoc test LSD. Hasil. Pemberian salep ekstrak etanol 70% daun karamunting mengakibatkan peningkatan jumlah sel fibroblas namun tidak memberikan perbedaan secara bermakna. Kesimpulan. Salep ekstrak etanol 70% daun karamunting tidak memberikan efek peningkatan jumlah pertumbuhan sel fibroblas secara bermakna di hari ke-10 pada luka insisi kulit tikus putih jantan galur wistar.

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Turnip, Nur Ulina M. Br, Nurdianti ., and Cucu Arum Dwicahya. "UJI EFEKTIVITAS ANTIBAKTERI SEDIAAN SALEP DARI EKSTRAK DAUN KERSEN (Muntingia calabura L.) TERHADAP BAKTERI Staphylococcus aureus." JURNAL FARMASIMED (JFM) 2, no. 2 (April 30, 2020): 85–90. http://dx.doi.org/10.35451/jfm.v2i2.373.

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Salah satu penyebab infeksi adalah bakteri, seperti Staphylococcus aureus. Daun kersen telah banyak digunakan untuk mengobati penyakit yang disebabkan oleh bakteri. Daun kersen telah diteliti memiliki aktivitas antibakteri terhadap bakteri Staphylococcus aureus. Tujuan penelitian ini: membuat formulasi sediaan salep ekstrak daun kersen, dan melihat apakah sediaan salep memiliki aktivitas antibakteri terhadap bakteri Staphylococcus aureus. Metode penelitian yang dilakukan pada penelitian ini bersifat True experimental, meliputi tahapan: pembuatan ekstrak daun kersen dengan metode maserasi menggunakan pelarut etanol 96%, formulasi salep dibuat dengan dasar salep: vaselin, adeps lanae, dan propilen glikol. Dibuat dalam tiga konsentrasi yaitu: F I dengan 100 mg, F II dengan 200 mg, dan F III dengan 300 mg. Selanjutnya dilakukan evaluasi sediaan berupa evaluasi stabilitas fisik dan homogenitas, dan uji aktivitas dengan bakteri Staphylococcus aureus dengan menggunakan metode difusi agar menggunakan kertas cakram. Hasil menunjukkan bahwa salep memiliki kestabilan fisik dan homogenitas yang baik selama 10 hari penyimpanan pada suhu kamar. Uji aktivitas antibakteri sediaan salep menunjukkan bahwa diameter hambat F I memiliki rata-rata 14,35 mm, F II memiliki rata-rata 16,50 mm dan F III memiliki rata-rata 19,29 mm. Berdasarkan hasil yang diperoleh maka dapat disimpulkan bahwa sediaan salep ekstrak daun kersen memiliki daya hambat terhadap bakteri Staphylococcus aureus. Pada peneliti selanjutnya diharapkan agar memperhatikan daerah tumbuh daun kersen yang akan digunakan sebagai sapel penelitian dan melakukan perbandingan pengujian aktivitas antibakteri antara daun kersen dengan daun yang lainnya terhadap bakteri Staphylococcus aureus.

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Gao, Qing, Maojuan Guo, Xijuan Jiang, Xiantong Hu, Yijing Wang, and Yingchang Fan. "A Cocktail Method for Promoting Cardiomyocyte Differentiation from Bone Marrow-Derived Mesenchymal Stem Cells." Stem Cells International 2014 (2014): 1–11. http://dx.doi.org/10.1155/2014/162024.

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A growing body of evidence supports the argument that bone marrow-derived mesenchymal stem cells (MSCs) can differentiate into cardiomyocyte-like cells in an appropriate cellular environment, but the differentiation rate is low. A cocktail method was designed: we investigated the role of 5-azacytidine (5-aza), salvianolic acid B (SalB), and cardiomyocyte lysis medium (CLM) in inducing MSCs to acquire the phenotypical characteristics of cardiomyocytes. The fourth-passage MSCs were treated with 5-aza, SalB, CLM, 5-aza+salB, 5-aza+CLM, SalB+CLM, and 5-aza+SalB+CLM for 2 weeks. Immunofluorescence results showed that cTnT expression in the 5-aza+salB+CLM group was stronger than other groups. Real-time qPCR and Western blotting analyses showed that cTnT, alpha-cardiac actin, mef-2c, Cx43, and GSK-3beta expression increased while beta-catenin expression decreased. The salB+5-aza+CLM group had the most evident effects. SalB combined with 5-aza and CLM improved cardiomyocyte differentiation from MSCs. In the MSCs differentiation process, the Wnt/beta-catenin signaling pathway had been inhibited.

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Kreziou, Anna, Hugo de Boer, and Barbara Gravendeel. "Harvesting of salep orchids in north-western Greece continues to threaten natural populations." Oryx 50, no. 3 (April 28, 2015): 393–96. http://dx.doi.org/10.1017/s0030605315000265.

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AbstractIn several eastern Mediterranean countries orchids are collected from the wild for the production of salep, a beverage made of dried orchid tubers. The drivers of this collection and trade have changed over time. We investigated which genera and species are harvested for salep production, whether any cultivation takes place, the chain of commercialization, and the economic value of tuber collection. Fieldwork and interviews in north-western Greece included 25 collectors and street vendors, the owners of two companies, and one herbal shop. The results show that several orchid species are traded for the production of salep, and none are cultivated. Tubers collected in Greece, Albania and Turkey are sold in northern Greece for EUR 55–150 per kg on average. Recent catalysts such as the increasing demand for traditional, organic and alternative foodstuffs, and the 2009 economic downturn, have led to a revival of salep consumption, with an increasing number of salep harvesters from Greece and Albania scouring the mountains for harvestable tubers, using unsustainable harvesting practices.

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Dayanti, Efin Windi, Arimbi Arimbi, Maya Nurwartanti Yunita, Hani Plumeriastuti, Muhammad Thohawi Elziyad Purnama, and Prima Ayu Wibawati. "Efektivitas Kitosan Dari Limbah Kulit Udang Terhadap Angiogenesis dalam Penyembuhan Luka Eksisi pada Tikus Putih (Rattus norvegicus) Jantan." Media Kedokteran Hewan 32, no. 2 (May 22, 2021): 60. http://dx.doi.org/10.20473/mkh.v32i2.2021.60-69.

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Luka eksisi adalah luka yang disebabkan akibat terpotongnya jaringan oleh benda yang tajam (Partogi, 2008). Kitosan mampu sebagai zat dalam penyembuhan luka salah satunya dalam proses angiogenesis. Tujuan penelitian ini yaitu untuk mengetahui efektivitas salep kitosan dari limbah kulit udang terhadap angiogenesis dalam penyembuhan luka eksisi pada tikus putih jantan. Sebanyak dua puluh ekor tikus putih (Rattus norvegicus) jantan dibagi ke dalam lima kelompok perlakuan yaitu K+ luka eksisi dengan pemberian povidone iodine, K- luka eksisi dengan pemberian salep tanpa kitosan, P1 luka eksisi dengan pemberian salep kitosan 1,5%, P2 luka eksisi dengan pemberian salep 2,5% dan P3 luka eksisi dengan pemberian salep kitosan. Terapi diberikan sehari sekali selama tujuh hari. Hasil data rata-rata jumlah pembuluh darah baru dianalisis dengan uji Anova yang menunjukkan adanya perbedaan yang signifikan (p<0,05) dan dilanjutkan dengan uji LSD (Least Significant Differences). Kelompok P1 dan P2 tidak memiliki perbedaan yang nyata, tetapi berbeda nyata dengan kelompok K+, K- dan P3. Kesimpulan dari penelitian ini kitosan efektif dalam meningkatkan jumlah pembuluh darah baru pada proses penyembuhan luka eksisi.

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Faure, Denis, Jos Desair, Veerle Keijers, My Ali Bekri, Paul Proost, Bernard Henrissat, and Jos Vanderleyden. "Growth of Azospirillum irakense KBC1 on the Aryl β-Glucoside Salicin Requires either salA or salB." Journal of Bacteriology 181, no. 10 (May 15, 1999): 3003–9. http://dx.doi.org/10.1128/jb.181.10.3003-3009.1999.

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ABSTRACT The rhizosphere nitrogen-fixing bacteriumAzospirillum irakense KBC1 is able to grow on pectin and β-glucosides such as cellobiose, arbutin, and salicin. Two adjacent genes, salA and salB, conferring β-glucosidase activity to Escherichia coli, have been identified in a cosmid library of A. irakense DNA. The SalA and SalB enzymes preferentially hydrolyzed aryl β-glucosides. A Δ(salA-salB) A. irakense mutant was not able to grow on salicin but could still utilize arbutin, cellobiose, and glucose for growth. This mutant could be complemented by either salA or salB, suggesting functional redundancy of these genes in salicin utilization. In contrast to this functional homology, the SalA and SalB proteins, members of family 3 of the glycosyl hydrolases, show a low degree of amino acid similarity. Unlike SalA, the SalB protein exhibits an atypical truncated C-terminal region. We propose that SalA and SalB are representatives of the AB and AB′ subfamilies, respectively, in glycosyl hydrolase family 3. This is the first genetic implication of this β-glucosidase family in the utilization of β-glucosides for microbial growth.

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Wilcock, Chris. "More salep, please." Trends in Plant Science 6, no. 7 (July 2001): 332. http://dx.doi.org/10.1016/s1360-1385(01)01986-0.

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Mastuti, Sri, Djoko Tri Hadi, and Chodidjah Chodidjah. "Nigella Sativa Seed Extract Ointment Increasing the Amount of Healing Fibroblast and Collagen on Balb/C Mice." Sains Medika 8, no. 1 (April 4, 2017): 15. http://dx.doi.org/10.26532/sainsmed.v8i1.1006.

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LATAR BELAKANG: Luka tidak sembuh dalam waktu lama dengan berbagai penyebab merupakan masalah yang sering ditemukan dalam berbagai disiplin kedokteran. Kejadian ini salah satu sumber utama morbiditas, penyebab gangguan psikologis para penderita, meningkatkan biaya pengobatan dan kehilangan jam kerja pada penderita usia produktif.�TUJUAN: untuk mengetahui pengaruh ekstrak biji jinten hitam (Nigella sativa) dalam sediaan salep sebanyak 40% dan 60% terhadap jumlah fibroblas dan kolagen pada penyembuhan luka sayat mencit balb/c.METODE: Penelitian eksperimental dengan rancangan �post test only control group design� pada 48 ekor mencit jantan galur balb/c, dibagi menjadi 4 kelompok pengujian fibroblast (24 ekor) dan 4 kelompok pengujian kolagen (24 ekor). Masing-masing kelompok terdiri dari 6 ekor sampel yang dipilih secara random. Salep ekstrak Nigella sativa dengan konsentrasi 40% dan dengan konsentrasi 60% dioles sebanyak 3x sehari selama 7 hari pada kelompok fibroblast dan selama 14 hari pada kelompok kolagen. Data dianalisis dengan Kruskal-Wallis.HASIL: Analisis jumlah fibroblast antara kelompok kontrol/tidak diberikan perlakuan dan kelompok yang diberikan salep garamycin terdapat perbedaan (p value =0,010), antara kelompok kontrol dan kelompok yang diberikan salep ekstrak jinten hitam 40 % tidak ada perbedaan (p value =0,065), pada kelompok yang diberikan salep ekstrak jinten hitam 60 % terdapat perbedaan (p value =0,025). Hasil analisis jumlah kolagen menunjukkan perbedaan antara semua kelompok (p value =0,004).KESIMPULAN: Pemberian salep ekstrak biji jinten hitam (Nigella sativa) dapat meningkatkan jumlah fibroblas dan kolagen pada penyembuhan� luka sayat kulit mencit galur balb/c.

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de Boer, Hugo J., Abdolbaset Ghorbani, Vincent Manzanilla, Ancuta-Cristina Raclariu, Anna Kreziou, Sarawut Ounjai, Maslin Osathanunkul, and Barbara Gravendeel. "DNA metabarcoding of orchid-derived products reveals widespread illegal orchid trade." Proceedings of the Royal Society B: Biological Sciences 284, no. 1863 (September 20, 2017): 20171182. http://dx.doi.org/10.1098/rspb.2017.1182.

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In eastern Mediterranean countries orchids continue to be collected from the wild for the production of salep, a beverage made of dried orchid tubers. In this study we used nrITS1 and nrITS2 DNA metabarcoding to identify orchid and other plant species present in 55 commercial salep products purchased in Iran, Turkey, Greece and Germany. Thirty samples yielded a total of 161 plant taxa, and 13 products (43%) contained orchid species and these belonged to 10 terrestrial species with tuberous roots. Another 70% contained the substitute ingredient Cyamopsis tetraganoloba (Guar). DNA metabarcoding using the barcoding markers nrITS1 and nrITS2 shows the potential of these markers and approach for identification of species used in salep products. The analysis of interspecific genetic distances between sequences of these markers for the most common salep orchid genera shows that species level identifications can be made with a high level of confidence. Understanding the species diversity and provenance of salep orchid tubers will enable the chain of commercialization of endangered species to be traced back to the harvesters and their natural habitats, and thus allow for targeted efforts to protect or sustainably use wild populations of these orchids.

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HÜRKUL, Muhammed Mesud, Rahime ÇİFTÇİ, and Ayşegül KÖROĞLU. "Salep ve salep içeren ürünlerin gıda ve eczacılık açısından incelenmesi." Biological Diversity and Conservation 13, no. 2 (August 15, 2020): 144–52. http://dx.doi.org/10.46309/biodicon.2020.742692.

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Caravaca, Francisco, Manuel Arrobas, and Carmen Dominguez. "Serum Albumin and Other Serum Protein Fractions in Stable Patients on Peritoneal Dialysis." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 20, no. 6 (November 2000): 703–7. http://dx.doi.org/10.1177/089686080002000621.

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Background Hypoalbuminemia is common in peritoneal dialysis (PD) patients; but the reduction in serum albumin levels (SAlb) that should be expected in stable PD patients is less clear. Objectives To determine prospectively, in a group of stable PD patients without comorbid conditions, the changes in SAlb concentration and in the concentrations of the other serum protein fractions. To investigate the best determinants of a significant decrease in SAlb levels. Design Prospective observational study. Methods Seventeen PD patients in stable clinical condition, with no signs of systemic inflammatory response, were included in the study. SAlb and the electrophoretic pattern of serum proteins were determined immediately before PD start, and after 6, 9, 12, 15, 18, 21, and 24 months on PD. In each study period, clinical characteristics, adequacy parameters, protein catabolic rate (PNPNA: protein equivalent of non protein nitrogen appearance), and protein losses were determined. Patients were divided into two subgroups according to whether SAlb decreased less than 10%, or 10% or more, from baseline values after 24 months on PD. The main differences between the subgroups were investigated. Results Mean SAlb did not decrease significantly after 24 months on PD (from baseline 3.99 ± 0.46 g/dL to 3.80 ± 0.54 g/dL), though percentage SAlb values did (58.36% ± 5.58% vs 55.15% ± 5.42%, p < 0.01). A weak increase in α2-globulin was observed after 18 months on PD (from 10.62% ± 2.53% to 12.96% ± 2.51%, p = 0.001). α1-Globulin showed a sustained increase from a mean baseline value of 3.51% ± 1.09% to 6.83% ± 2.13% after 24 months ( p < 0.0001). Seven patients had a reduction in SAlb greater than 10% after 24 months on PD. Kt/V urea and residual renal function tended to be lower in patients whose SAlb decreased. Mean PNPNA was significantly lower in patients who had a reduction in SAlb (0.76 ± 0.12 g/kg/day vs 0.96 ± 0.12 g/kg/day, p < 0.0001). However, total protein loss was even greater in patients who had no SAlb reduction. Conclusions After 24 months on PD, a mean reduction in SAlb of 10% – 15% from baseline values should be expected only in those stable patients whose PNPNA is low.

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Sandi, Dita Ayulia Dwi, and Yaumi Musfirah. "PENGARUH BASIS SALEP HIDROKARBON DAN BASIS SALEP SERAP TERHADAP FORMULASI SALEP SARANG BURUNG WALET PUTIH (Aerodramus fuciphagus)." Jurnal Ilmiah Manuntung 4, no. 2 (December 28, 2018): 149. http://dx.doi.org/10.51352/jim.v4i2.194.

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Swiftlet nest is edible bird’s nest (EBN). Edible bird’s nest contain EGF (Epidermal Growth Factor) that has a role in skin cell regeneration. This research aims to find out the effect of the hydrocarbon and absorption bases on the edible bird’s nest ointment (Aerodramus fuciphagus) from the physical character of each ointment. The edible bird’s nest ointment made into two formula with hydrocarbonand absorption bases. Each ointment tested of the physical characteristics include organoleptic test, homogenity test, pH test, spreading test, sticky test, and viscosity test. The data obtained was analyzed statistically using T Independent Test. The result showed that there was affect the hydrocarbon and absorption bases to the physical characteristics of edible bird’s nest ointment include spreadability (P 0,011), sticky (P 0,020), and viscosity, but there was not affect to organoleptic, homogenity and pH of edible white bird’s nest ointment (Aerodramus fuciphagus).

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Tavakolizadeh, Maryam, Ali Pourjavadi, Maryam Ansari, Hamid Tebyanian, Seyyed Javad Seyyed Tabaei, Monireh Atarod, Navid Rabiee, Mojtaba Bagherzadeh, and Rajender S. Varma. "An environmentally friendly wound dressing based on a self-healing, extensible and compressible antibacterial hydrogel." Green Chemistry 23, no. 3 (2021): 1312–29. http://dx.doi.org/10.1039/d0gc02719g.

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A self-healing wound dressing hydrogel is prepared through Schiff-base cross-linking between oxidized salep (OSa) and ethylene diamine-modified salep (SaHEA) as first network and physical cross-linking of PVA via freezing-thawing as the second network.

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Metfies, Katja, Anja Nicolaus, Lena Von Harbou, Ulrich Bathmann, and Ilka Peeken. "Molecular analyses of gut contents: elucidating the feeding of co-occurring salps in the Lazarev Sea from a different perspective." Antarctic Science 26, no. 5 (May 12, 2014): 545–53. http://dx.doi.org/10.1017/s0954102014000157.

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AbstractThe diet of Antarctic salps was elucidated by investigating their gut content using automated ribosomal intergenic spacer analysis (ARISA) and 454-pyrosequencing. Salp samples were collected during the Lazarev Sea Krill Study in the western Weddell Sea (summer 2005–06 and 2007–08, autumn 2004 and winter 2006). Two salp species,Salpa thompsoniandIhlea racovitzai, both occur in the Southern Ocean and can overlap geographically and seasonally. We provide evidence that, despite the non-selective feeding mechanism, the two co-occurring salp species might have different niches within a habitat. ARISA-patterns of 93 gut content samples revealed strong differences between the two salp species, even at the same sampling site. These differences were confirmed by 454-pyrosequencing of the V4-18S rDNA of ten salps. The pyrosequencing data indicate that flagellates, in particular dinophyceae, constitute a high proportion of the sequence reads identified in the gut content of both salp species. However, within the dinophyceae, differences in the read composition were detected between the two salp species. This supports the findings of a previous study where fatty acid signatures indicate a flagellate-based diet, even though microscopic analyses identified diatoms as the dominant component of salp gut contents.

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Zuniarto, Ahmad Azrul, and Rizki Rahmah Fauzia. "UJI EFEKTIVITAS SALEP EKSTRAK HERBA PEGAGAN (Centella asiatica (L.) Urban) TERHADAP LUKA BEDAH PADA TIKUS." Journal of Holistic and Health Sciences 1, no. 2 (January 8, 2018): 94–100. http://dx.doi.org/10.51873/jhhs.v1i2.9.

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Latar Belakang: Pegagan (Centella asiatica (L.) Urban) telah diteliti mempunyai aktivitas penyembuhan luka yang baik pada luka bedah dengan menstimulasi sintesis kolagen, meningkatkan sekresi kolagen, merangsang proliferasi fibroblast, aktivitas antibakteri dan antioksidan. Tujuan Penelitian: Untuk mengetahui efektivitas salep ekstrak herba Pegagan (Centella asiatica (L.) Urban) terhadap penyembuhan luka bedah pada tikus putih jantan dan untuk mengetahui konsentrasi salep ekstrak herba Pegagan (Centella asiatica (L.) Urban) yang paling efektif terhadap penyembuhan luka bedah pada tikus putih jantan. Metode: Metode yang digunakan adalah penelitian eksperimental. Hewan percobaan dibagi dalam 5 kelompok yaitu kelompok X1 merupakan kelompok uji dengan ekstrak herba Pegagan 2,5%, kelompok X2 merupakan kelompok uji dengan ekstrak herba Pegagan 5%, kelompok X3 merupakan kelompok uji dengan ekstrak herba Pegagan 10%, kelompok K(+) merupakan kelompok uji dengan kontrol positif, dan kelompok K(-) merupakan kelompok uji dengan kontrol negatif. Hasil: Hasil penelitian menunjukkan bahwa salep ekstrak Pegagan dengan konsentrasi 5% dan 10% dapat menyembuhkan luka lebih baik dibandingkan dengan kontrol positif. Sedangkan salep ekstrak Pegagan dengan konsentrasi 2,5% tidak mempunyai perbedaaan yang signifikan dibandingkan dengan kontrol positif (povidone iodine). Simpulan: Pemberian salep ekstrak herba Pegagan (Centella asiatica (L.) Urban) dengan konsentrasi 2,5%, 5%, dan 10% efektif terhadap penyembuhan luka bedah pada tikus putih jantan.

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Journal articles on the topic 'SALBP'

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