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Journal articles on the topic 'Salivary peptide'

Author: Grafiati

Published: 11 March 2023

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1

Ito, Seiki, Toshimitsu Suzuki, Takeshi Momotsu, et al. "Presence of salivary Protein C and salivary peptide P-C-like immunoreactivity in the laryngo-tracheo-bronchial glands." Acta Endocrinologica 108, no. 1 (1985): 130–34. http://dx.doi.org/10.1530/acta.0.1080130.

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Abstract. An indirect immunofluorescence technique using antisera aganist salivary peptide P-C and against salivary Protein C was carried out on the laryngeal, tracheal and bronchial glands to examine whether salivary peptide P-C-like immunoreactivity, recently demonstrated in the serous cells of the human salivary glands, was also present in those of laryngeal, tracheal and bronchial glands and to ascertain whether salivary peptide P-C is a fragment of salivary Protein C or not. Salivary peptide P-C-like immunoreactivity was present in the serous cells of the human laryngeal, tracheal and bro

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Nicolodi, Maria, and Elena Del Bianco. "Sensory Neuropeptides (Substance P, Calcitonin Gene-Related Peptide) and Vasoactive Intestinal Polypeptide in Human Saliva: Their Pattern in Migraine and Cluster Headache." Cephalalgia 10, no. 1 (1990): 39–50. http://dx.doi.org/10.1046/j.1468-2982.1990.1001039.x.

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Substance P, calcitonin gene-related peptide and vasoactive intestinal polypeptide-like immunoreactivities have been evaluated in the saliva of 15 subjects suffering from migraine without aura and 16 control subjects. All three peptides were also measured in the symptomatic/non-symptomatic side saliva sampled from 10 cluster headache sufferers during the cluster period, 5 cluster headache sufferers out of the cluster period, as well as in the right and left side saliva of 18 control subjects. The most interesting result gives a clear difference in common migraine and cluster headache salivary

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3

Ito, Seiki, Toshimitsu Suzuki, Tooru Izumi, et al. "Intracellular localization of salivary peptide P-C-like immunoreactivity in the human pancreatic B-cells." Acta Endocrinologica 108, no. 1 (1985): 119–29. http://dx.doi.org/10.1530/acta.0.1080119.

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Abstract. In order to clarify the intracellular localization of salivary peptide P-C-like immunoreactivity in human pancreatic B-cells, an immunohistochemical study at electron microscopic levels was carried out by the protein A-gold technique using antisera against insulin and salivary peptide P-C. Both salivary peptide P-C-like immunoreactivity and insulin-like immunoreactivity were present only in the insulin secretory granules of the pancreatic B-cells. However, the former immunoreactivity was lacking in many insulin secretory granules of foetal pancreatic B-cells while the latter immunore

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4

Veenstra, Jan A. "The salivary gland salivation stimulating peptide from Locusta migratoria (Lom-SG-SASP) is not a typical neuropeptide." PeerJ 5 (July 26, 2017): e3619. http://dx.doi.org/10.7717/peerj.3619.

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The salivary gland salivation stimulating peptide was identified from the salivary glands of the migratory locust by its ability to stimulate cAMP production in the same tissue. The gene coding for this peptide has recently been identified and been shown to code for a precursor consisting of a signal peptide, several copies of the peptide separated by Lys–Arg doublets and a few other peptides. These data are consistent with it being a neuropeptide. However, antiserum raised to this peptide labels the acini of the salivary glands while RT-PCR only gives positive results in the salivary gland, b

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Morris, Katherine E., Chris D. St. Laurent, Ryan S. Hoeve, et al. "The sympathetic nervous system regulates the release of anti-inflammatory peptides from salivary glands (93.18)." Journal of Immunology 182, no. 1_Supplement (2009): 93.18. http://dx.doi.org/10.4049/jimmunol.182.supp.93.18.

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Abstract Chronic and acute stress have profound effects on inflammation. In rats, allergic inflammation is regulated by the sympathetic nervous system acting on salivary glands. Human asthma is frequently accompanied by salivary gland inflammation. Salivary gland dysfunction in stressed individuals could enhance asthma severity. Salivary gland prohormone SMR1 (submandibular rat-1) is cleaved into two peptides that are anti-inflammatory in rats, mice, dogs, sheep, cats, and human cells in pulmonary inflammation, food allergy, septic shock, pancreatitis, and spinal cord injury. We hypothesized t

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Yi, Ting Chun, and Shabbir Moochhala. "Mini-Review Article – Current Opinion on Salivary Biomarkers as a Measurement for Stress and Fatigue." Open Biomarkers Journal 6, no. 1 (2013): 9–14. http://dx.doi.org/10.2174/1875318301306010009.

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Salivary biomarkers have been increasingly popular in stress research as saliva is easily produced and collection is non-invasive and not limited by geographical distance or lack of infrastructure. Several salivary biomarkers have been utilized in stress research, for instance, salivary cortisol, salivary amylase and salivary immunoglobulin A. Despite being sensitive to changes in fatigue, they have limitations such as inter-individual variability, and interactions with other constituents that may confound the results. Recently, Hyperion Biotechnology has developed the Fatigue Biomarker Index

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7

Tao, Renchuan, Richard J. Jurevic, Kimberly K. Coulton, et al. "Salivary Antimicrobial Peptide Expression and Dental Caries Experience in Children." Antimicrobial Agents and Chemotherapy 49, no. 9 (2005): 3883–88. http://dx.doi.org/10.1128/aac.49.9.3883-3888.2005.

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ABSTRACT Dental caries is a major worldwide oral disease problem in children. Although caries are known to be influenced by dietary factors, the disease results from a bacterial infection; thus, caries susceptibility may be affected by host factors such as salivary antimicrobial peptides. This study aimed to determine a possible correlation between caries prevalence in children and salivary concentrations of the antimicrobial peptides human beta-defensin-3 (hBD-3), the cathelicidin LL37, and the alpha-defensins HNP1-3 (a mixture of HNP1, 2, 3). Oral examinations were performed on 149 middle sc

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Yasuda, Takuya, Koichiro Tahara, and Tetsuji Sawada. "Detection of salivary citrullinated cytokeratin 13 in healthy individuals and patients with rheumatoid arthritis by proteomics analysis." PLOS ONE 17, no. 3 (2022): e0265687. http://dx.doi.org/10.1371/journal.pone.0265687.

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The immune response to citrullinated peptides in the mucosa has been suggested to play an important role in the transition from pre-onset rheumatoid arthritis (RA) to clinically evident RA. Although there are reports indicating the presence of anti-citrullinated peptide antibodies in the saliva, few studies have reported citrullinated peptide detection in human saliva. This study aimed to identify citrullinated peptides in human saliva and discuss their clinical significance. Saliva samples were collected from 11 patients with RA and from 20 healthy individuals. Citrullinated peptides were det

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9

Ito, Seiki, Toshimitsu Suzuki, Satoko Isemura, et al. "'Salivary peptide P-C' of human pancreatic B-cells shares only partly immunoreactivity with salivary peptide P-C indicating a new B-cell protein which is different from insulin." Acta Endocrinologica 120, no. 1 (1989): 62–68. http://dx.doi.org/10.1530/acta.0.1200062.

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Abstract. Salivary peptide P-C like immunoreactivity, originally isolated from human whole saliva has later been found in the human pancreatic B-cells. In the present work an indirect immunofluorescence technique using monoclonal antibodies against isolated salivary peptide P-C was applied to Bouin fixed pancreas and parotid glands to study the possible identity of the two substances. Positive P-C immunofluroescence was found in the serous cells of parotid glands but not in pancreatic B-cells, suggesting that pancreatic P-C substance is not salivary peptide P-C itself, but a substance sharing

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Hamada, Tomoyuki, Masatsugu Kawashima, Haruo Watanabe, Junji Tagami, and Hidenobu Senpuku. "Molecular Interactions of Surface Protein Peptides of Streptococcus gordonii with Human Salivary Components." Infection and Immunity 72, no. 8 (2004): 4819–26. http://dx.doi.org/10.1128/iai.72.8.4819-4826.2004.

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ABSTRACT Oral streptococci play a large role in dental biofilm formation, and several types interact as early colonizers with the enamel salivary pellicle to form the primary biofilm, as well as to incorporate other bacteria on tooth surfaces. Interactions of surface molecules of individual streptococci with the salivary pellicle on the tooth surface have an influence on the etiological properties of an oral biofilm. To elucidate the molecular interactions of streptococci with salivary components, binding between surface protein (SspB and PAg) peptides of Streptococcus gordonii and Streptococc

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Bachrach, G., G. Chaushu, M. Zigmond, et al. "Salivary LL-37 Secretion in Individuals with Down Syndrome is Normal." Journal of Dental Research 85, no. 10 (2006): 933–36. http://dx.doi.org/10.1177/154405910608501012.

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Antimicrobial peptides play an important role in the innate immune response. Deficiency in salivary LL-37 antimicrobial peptide has been implicated in periodontitis in patients with morbus Kostman syndrome. Down syndrome is associated with periodontitis, diminished salivary flow, and salivary immunoglobulin deficiency. In the present study, levels of LL-37 and its hCAP18 precursor were measured in saliva samples from young individuals with Down syndrome and compared with levels in those from age-matched healthy controls. LL-37 and human cathelicidin antimicrobial protein (hCAP18) were detected

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Lamkin, Mark S., and Frank G. Oppenheim. "Structural Features of Salivary Function." Critical Reviews in Oral Biology & Medicine 4, no. 3 (1993): 251–59. http://dx.doi.org/10.1177/10454411930040030101.

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Saliva plays an important role in the maintenance of oral health by exhibiting multiple host defense functions. These include homeostatic processes, lubrication, antimicrobial activity, and the control of demineralization/remineralization of teeth. Biochemical studies of saliva and salivary secretions established that specific salivary proteins are responsible for these defense functions. Because some of these salivary proteins have been characterized extensively, including their primary structures, it has become feasible to explore their structure/function relationships. Acidic proline-rich p

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Almoudi, Manal Mohamed, Alaa Sabah Hussein, Mohamed Ibrahim Abu-Hassan, Bahruddin Saripudin, and Mohd Shawal Firdaus Mohamad. "The Association of Early Childhood Caries with Salivary Antimicrobial Peptide LL37 and Mutans Streptococci." Journal of Clinical Pediatric Dentistry 45, no. 5 (2021): 330–36. http://dx.doi.org/10.17796/1053-4625-45.5.7.

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Purpose: This study aims to determine the relation of salivary LL37 level and mutans streptococci levels in early childhood caries (ECC). Study design: A case-control study was performed in children ≤71 months old. Unstimulated whole saliva was collected and the level of salivary LL37 was measured using an enzyme-linked immunosorbent assay kit. The mutans streptococci oral bacteria were isolated from saliva and identified using a modified SB-20 culture medium (SB-20M). Data were analyzed using descriptive statistics, bivariate, and Spearman’s rank correlation analysis. Results: The was a varia

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Hormdee, Doosadee, Saengsome Prajaneh, Amonrujee Kampichai, Ranuch Tak, and Ponlatham Chaiyarit. "Prolonged Suppressive Effects of Periodontitis on Salivary TFF3 Production." European Journal of Dentistry 13, no. 02 (2019): 193–98. http://dx.doi.org/10.1055/s-0039-1693949.

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Abstract Objective As a follow-up to our previous study that demonstrated decreased salivary trefoil factor family 3 (TFF3) peptide levels in chronic periodontitis patients, this current study aimed to observe the effects of nonsurgical periodontal treatment on salivary TFF3 peptides in patients with periodontal diseases. Materials and Methods Eighty-seven volunteers that comprised of 30 individuals with healthy periodontium, 31 with gingivitis, and 26 with chronic periodontitis were considered for the study. Prior to periodontal treatment, a general periodontal examination was performed along

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Ribeiro, J. M. "Characterization of a vasodilator from the salivary glands of the yellow fever mosquito Aedes aegypti." Journal of Experimental Biology 165, no. 1 (1992): 61–71. http://dx.doi.org/10.1242/jeb.165.1.61.

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Salivary gland homogenates and oil-induced saliva of the mosquito Aedes aegypti dilate the rabbit aortic ring and contract the guinea pig ileum. The vasodilatory activity is endothelium-dependent, heat-stable, sensitive to both trypsin and chymotrypsin treatments, and both smooth muscle activities cross-desensitize to the tachykinin peptide substance P. Both bioactivities co-elute when salivary gland homogenates are fractionated by reversed-phase HPLC. Molecular sieving chromatography indicates a relative molecular mass of 1400. A monoclonal antibody specific to the carboxy terminal region of

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Hoffmann, Werner. "Salivary Trefoil Factor Family (TFF) Peptides and Their Roles in Oral and Esophageal Protection: Therapeutic Potential." International Journal of Molecular Sciences 22, no. 22 (2021): 12221. http://dx.doi.org/10.3390/ijms222212221.

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Human saliva is a complex body fluid with more than 3000 different identified proteins. Besides rheological and lubricating properties, saliva supports wound healing and acts as an antimicrobial barrier. TFF peptides are secreted from the mucous acini of the major and minor salivary glands and are typical constituents of normal saliva; TFF3 being the predominant peptide compared with TFF1 and TFF2. Only TFF3 is easily detectable by Western blotting. It occurs in two forms, a disulfide-linked homodimer (Mr: 13k) and a high-molecular-mass heterodimer with IgG Fc binding protein (FCGBP). TFF pept

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Kapas, S., K. Pahal, A. T. Cruchley, E. Hagi-Pavli, and J. P. Hinson. "Expression of Adrenomedullin and its Receptors in Human Salivary Tissue." Journal of Dental Research 83, no. 4 (2004): 333–37. http://dx.doi.org/10.1177/154405910408300412.

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Adrenomedullin is a multifunctional peptide produced by a wide range of different cells and tissues. This study was designed to investigate whether adrenomedullin is present in human saliva and in salivary glands. It was expected that saliva may contain high concentrations of adrenomedullin, which has antimicrobial activity in vitro, which may have functional implications in the oral cavity. Saliva from the submandibular and parotid glands contained higher concentrations of adrenomedullin than did the circulation, but lower concentrations than in whole saliva. This suggests that oral epitheliu

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Morris, K. E., C. D. St. Laurent, R. S. Hoeve, et al. "Autonomic nervous system regulates secretion of anti-inflammatory prohormone SMR1 from rat salivary glands." American Journal of Physiology-Cell Physiology 296, no. 3 (2009): C514—C524. http://dx.doi.org/10.1152/ajpcell.00214.2008.

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The autonomic nervous system regulates the secretion of bioactive proteins and peptides from salivary glands that can be important in systemic physiological responses. The prohormone submandibular rat-1, which is highly expressed in rat submandibular glands, can be cleaved to produce polypeptides with analgesic and anti-inflammatory activities. Human genes related to submandibular rat-1 have conserved biological functions and are potentially important in pain suppression, erectile function, and inflammation. In this study we describe the differential expression and posttranslational modificati

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Rowzee, Anne M., Niamh X. Cawley, John A. Chiorini, and Giovanni Di Pasquale. "Glucagon-Like Peptide-1 Gene Therapy." Experimental Diabetes Research 2011 (2011): 1–5. http://dx.doi.org/10.1155/2011/601047.

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Glucagon-like peptide 1 (GLP-1) is a small peptide component of the prohormone, proglucagon, that is produced in the gut. Exendin-4, a GLP-1 receptor agonist originally isolated from the saliva ofH. suspectumor Gila monster, is a peptide that shares sequence and functional homology with GLP-1. Both peptides have been demonstrated to stimulate insulin secretion, inhibit glucagon secretion, promote satiety and slow gastric emptying. As such, GLP-1 and Exendin-4 have become attractive pharmaceutical targets as an adjunctive therapy for individuals with type II diabetes mellitus, with several prod

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Smith, Daniel J., William F. King, Leigh A. Barnes, Debra Trantolo, Donald L. Wise, and Martin A. Taubman. "Facilitated Intranasal Induction of Mucosal and Systemic Immunity to Mutans Streptococcal Glucosyltransferase Peptide Vaccines." Infection and Immunity 69, no. 8 (2001): 4767–73. http://dx.doi.org/10.1128/iai.69.8.4767-4773.2001.

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ABSTRACT Synthetic peptide vaccines which are derived from functional domains of Streptococcus mutans glucosyltransferases (GTF) have been shown to induce protective immunity in Sprague-Dawley rats after subcutaneous injection in the salivary gland region. Since mucosal induction of salivary immunity would be preferable in humans, we explored methods to induce mucosal antibody in the rat to the GTF peptide vaccines HDS and HDS-GLU after intranasal administration. Several methods of facilitation of the immune response were studied: the incorporation of peptides in bioadhesive poly(d,l-lactide-c

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Smith, P. H., and B. B. Toms. "Immunocytochemical localization of insulin- and glucagonlike peptides in rat salivary glands." Journal of Histochemistry & Cytochemistry 34, no. 5 (1986): 627–32. http://dx.doi.org/10.1177/34.5.3517146.

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An avidin-biotin immunocytochemical technique was used to localize cells containing an insulin- or glucagon-like peptide in the major salivary glands of Sprague-Dawley rats. Cells with insulin-like staining were observed in the intercalated ducts of both the parotid and submandibular glands, but none were found in the sublingual gland. A discrete population of cells with intense glucagon-like immunostaining was associated with the acini of all three major salivary glands. This immunostaining only followed use of a glucagon antiserum with N-terminal specificity and not after incubation of tissu

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Nogueira, R. D., W. F. King, G. Gunda, et al. "Mutans Streptococcal Infection Induces Salivary Antibody to Virulence Proteins and Associated Functional Domains." Infection and Immunity 76, no. 8 (2008): 3606–13. http://dx.doi.org/10.1128/iai.00214-08.

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ABSTRACTThe interplay between mucosal immune responses to natural exposure to mutans streptococci and the incorporation and accumulation of these cariogenic microorganisms in oral biofilms is unclear. An initial approach to explore this question would be to assess the native secretory immunity emerging as a consequence ofStreptococcus mutansinfection. To this end, we analyzed salivary immunoglobulin A (IgA) antibody to mutans streptococcal glucosyltransferase (Gtf) and glucan binding protein B (GbpB) and to domains associated with enzyme function and major histocompatibility complex (MHC) clas

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Amano, Atsuo, Satoshi Shizukuishi, Hiroshi Horie, Shigenobu Kimura, Ichijiro Morisaki, and Shigeyuki Hamada. "Binding of Porphyromonas gingivalisFimbriae to Proline-Rich Glycoproteins in Parotid Saliva via a Domain Shared by Major Salivary Components." Infection and Immunity 66, no. 5 (1998): 2072–77. http://dx.doi.org/10.1128/iai.66.5.2072-2077.1998.

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ABSTRACT Porphyromonas gingivalis, a putative periodontopathogen, can bind to human saliva through its fimbriae. We previously found that salivary components from the submandibular and sublingual glands bind to P. gingivalis fimbriae and that acidic proline-rich protein (PRP) and statherin function as receptor molecules for fimbriae. In this study, we investigated the fimbria-binding components in parotid saliva. Fractionated human parotid saliva by gel-filtration chromatography was immobilized onto nitrocellulose membranes for the overlay assay following sodium dodecyl sulfate-polyacrylamide

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Aidoukovitch, Alexandra, Sara Bodahl, Ellen Tufvesson, and Bengt-Olof Nilsson. "Desquamated Epithelial Cells of Unstimulated Human Whole Saliva Express Both EGF Transcript and Protein." International Journal of Dentistry 2022 (December 17, 2022): 1–9. http://dx.doi.org/10.1155/2022/3194703.

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Objective. The aim of this study was to investigate if desquamated oral epithelial cells (DOECs) express the epidermal growth factor (EGF) and if these cells thereby may contribute to salivary EGF contents. Background. DOECs have recently been shown to harbor the antimicrobial peptide LL-37, proposing that they may also store other biologically important salivary peptides/proteins. The EGF peptide is a growth factor which plays a critical role to maintain epithelial integrity and promote epithelial healing. The EGF is produced by salivary glands, but it is not known whether DOECs contain the E

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Dekker, Rebecca L., Terry A. Lennie, Debra K. Moser, et al. "Salivary Biomarkers, Oral Inflammation, and Functional Status in Patients With Heart Failure." Biological Research For Nursing 19, no. 2 (2016): 153–61. http://dx.doi.org/10.1177/1099800416665197.

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Aims: To describe correlations and agreement between salivary and serum B-type natriuretic peptide (BNP), C-reactive protein (CRP), interleukin (IL)-6, and IL-10 and determine which biomarkers predict worse functional class in patients with heart failure (HF). Methods: Serum and saliva were collected from 75 hospitalized patients with HF (57 ± 12 years, 43% female, New York Heart Association [NYHA] Classes I [4%], II [43%], and III [53%]). Oral inflammation was rated as good, fair, or poor. Spearman’s ρ and Bland–Altman were used to determine correlations and agreement of the salivary and seru

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Situ, Hongsa, and Libuse A. Bobek. "In Vitro Assessment of Antifungal Therapeutic Potential of Salivary Histatin-5, Two Variants of Histatin-5, and Salivary Mucin (MUC7) Domain 1." Antimicrobial Agents and Chemotherapy 44, no. 6 (2000): 1485–93. http://dx.doi.org/10.1128/aac.44.6.1485-1493.2000.

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ABSTRACT Human salivary histatin-5 (Hsn-5) is a 24-residue peptide that possesses potent antifungal activity in vitro. The MUC7gene encodes human salivary low-molecular-weight mucin (MG2). The candidacidal activity of MUC7 domain 1 (MUC7 D1, the N-terminal 51 amino acid residues of MUC7) in vitro has also been demonstrated. In this study, we have investigated the antifungal therapeutic potential of Hsn-5, its two variants, R12I/K17N and R12I/H21L, and MUC7 D1. First, these peptides were tested for activities against different clinically important fungi. We found them to possess broad-spectrum

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Messenger, B., MN Clifford, and LM Morgan. "Glucose-dependent insulinotropic polypeptide and insulin-like immunoreactivity in saliva following sham-fed and swallowed meals." Journal of Endocrinology 177, no. 3 (2003): 407–12. http://dx.doi.org/10.1677/joe.0.1770407.

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Gastrointestinal peptides, including insulin, glucagon and glucose-dependent insulinotropic polypeptide (GIP) have previously been reported in salivary glands. Recent evidence has suggested they might influence postprandial macronutrient metabolism. This study therefore investigated and compared postprandial hormone concentrations in saliva and plasma to determine whether their secretion was influenced by oral food stimuli. In a within-subject randomised cross-over comparison of hormone concentrations in plasma and saliva following a mixed meal, 12 subjects were given two 1708 kJ mixed meals.

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Huang, Chun-Ming, Justin W. Torpey, Yu-Tseung Liu, et al. "A Peptide with a ProGln C Terminus in the Human Saliva Peptidome Exerts Bactericidal Activity against Propionibacterium acnes." Antimicrobial Agents and Chemotherapy 52, no. 5 (2008): 1834–36. http://dx.doi.org/10.1128/aac.01347-07.

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ABSTRACT Nine proline-rich peptides ending with a proline-glutamine C terminus in a salivary peptidome were sequenced by matrix-assisted laser desorption ionization time of flight time of flight tandem mass spectrometry. A GPPPQGGRPQ peptide binds gram-positive Propionibacterium acnes and considerably inhibits bacterial growth. The peptide exhibiting innate immunity may be applied for treatment of various P. acnes-associated human diseases.

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Suzuki, Yosuke, Hiroki Itoh, Kohei Amada, Ryota Yamamura, Yuhki Sato, and Masaharu Takeyama. "Significant Increase in Salivary Substance P Level after a Single Oral Dose of Cevimeline in Humans." International Journal of Peptides 2013 (March 24, 2013): 1–6. http://dx.doi.org/10.1155/2013/284765.

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Cevimeline is a novel muscarinic acetylcholine receptor agonist currently being developed as a therapeutic agent for xerostomia. We examined the effects of cevimeline on salivary and plasma levels of substance-P- (SP-), calcitonin-gene-related-peptide- (CGRP-), and vasoactive-intestinal-polypeptide- (VIP-) like immunoreactive substances (ISs) in humans. An open-labeled crossover study was conducted on seven healthy volunteers. Saliva volume was measured, and saliva and venous blood samples were collected before and 30–240 min after a single oral dose of cevimeline or placebo. Salivary and plas

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Stie, Mai Bay, Johan Ring Gätke, Ioannis S. Chronakis, Jette Jacobsen, and Hanne Mørck Nielsen. "Mucoadhesive Electrospun Nanofiber-Based Hybrid System with Controlled and Unidirectional Release of Desmopressin." International Journal of Molecular Sciences 23, no. 3 (2022): 1458. http://dx.doi.org/10.3390/ijms23031458.

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The sublingual mucosa is an attractive route for drug delivery, although challenged by a continuous flow of saliva that leads to a loss of drug by swallowing. It is of great benefit that drugs absorbed across the sublingual mucosa avoid exposure to the harsh environment of the gastro-intestinal lumen; this is especially beneficial for drugs of low physicochemical stability such as therapeutic peptides. In this study, a two-layered hybrid drug delivery system was developed for the sublingual delivery of the therapeutic peptide desmopressin. It consisted of peptide-loaded mucoadhesive electrospu

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Gorr, Sven-Ulrik, Mahsa Abdolhosseini, Anuradha Shelar, and Julie Sotsky. "Dual host-defence functions of SPLUNC2/PSP and synthetic peptides derived from the protein." Biochemical Society Transactions 39, no. 4 (2011): 1028–32. http://dx.doi.org/10.1042/bst0391028.

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PSP (parotid secretory protein)/SPLUNC2 (short palate, lung and nasal epithelium clone 2) is expressed in human salivary glands and saliva. The protein exists as an N-glycosylated and non-glycosylated form and both appear to induce agglutination of bacteria, a major antibacterial function for salivary proteins. Both forms of PSP/SPLUNC2 bind LPS (lipopolysaccharide), suggesting that the protein may also play an anti-inflammatory role. Based on the predicted structure of PSP/SPLUNC2 and the location of known antibacterial and anti-inflammatory peptides in BPI (bactericidal/permeability-increasi

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LIGTENBERG, Antoon J. M., Floris J. BIKKER, Jolanda M. A. DE BLIECK-HOGERVORST, Enno C. I. VEERMAN, and Arie V. NIEUW AMERONGEN. "Binding of salivary agglutinin to IgA." Biochemical Journal 383, no. 1 (2004): 159–64. http://dx.doi.org/10.1042/bj20040265.

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SAG (salivary agglutinin), which is identical to gp-340 (glycoprotein-340) from the lung, is encoded by DMBT1 (deleted in malignant brain tumours 1). It is a member of the SRCR (scavenger receptor cysteine-rich) superfamily and contains 14 SRCR domains, 13 of which are highly similar. SAG in saliva is partially complexed with IgA, which may be necessary for bacterial binding. The goal of the present study was to characterize the binding of purified SAG to IgA. SAG binds to a variety of proteins, including serum and secretory IgA, alkaline phosphatase-conjugated IgGs originating from rabbit, go

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Oho, Takahiko, Floris J. Bikker, Arie V. Nieuw Amerongen, and Jasper Groenink. "A Peptide Domain of Bovine Milk Lactoferrin Inhibits the Interaction between Streptococcal Surface Protein Antigen and a Salivary Agglutinin Peptide Domain." Infection and Immunity 72, no. 10 (2004): 6181–84. http://dx.doi.org/10.1128/iai.72.10.6181-6184.2004.

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ABSTRACT The peptide domain of salivary agglutinin responsible for its interaction with cell surface protein antigen (PAc) of Streptococcus mutans or bovine lactoferrin was found in the same peptide, scavenger receptor cysteine-rich domain peptide 2 (SRCRP2). Inhibition studies suggest that PAc and lactoferrin, of which residues 480 to 492 seem important, competitively bind to the SRCRP2 domain of salivary agglutinin.

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Niemi, Liza Danielsson, and Ingegerd Johansson. "Salivary Statherin Peptide-Binding Epitopes of Commensal and Potentially Infectious Actinomyces spp. Delineated by a Hybrid Peptide Construct." Infection and Immunity 72, no. 2 (2004): 782–87. http://dx.doi.org/10.1128/iai.72.2.782-787.2004.

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ABSTRACT Adhesion of microorganisms to host receptor molecules such as salivary statherin molecules is a common event in oral microbial colonization. Here we used a hybrid peptide construct (with both a hydroxyapatite-binding portion and a test peptide portion) to map the interaction of Actinomyces species (and Candida albicans) with statherin. Adhesion to hybrid peptides and truncated statherin variants revealed three binding types, types I to III. (i) Type I strains of rat, hamster, and human infection origins bound C-terminal-derived QQYTF and PYQPQY peptides. The QQYTF peptide inhibited st

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Mathison, R. D., A. D. Befus, and J. S. Davison. "A novel submandibular gland peptide protects against endotoxic and anaphylactic shock." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 273, no. 3 (1997): R1017—R1023. http://dx.doi.org/10.1152/ajpregu.1997.273.3.r1017.

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Submandibular glands release peptides and proteins that, through exocrine and endocrine actions, facilitate tissue repair in the oral cavity, gastrointestinal tract, and more distal sites such as liver. It has been shown that salivary gland factors also modulate inflammatory responses, because we found that removal of the submandibular glands increases the hypotensive responses to endotoxin. From this observation we proposed that these glands contain a factor that regulates cardiovascular response to shock. With the use of classical peptide isolation procedures, a heptapeptide (TDIFEGG) called

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Londono-Renteria, Berlin, Papa M. Drame, Jehidys Montiel, et al. "Identification and Pilot Evaluation of Salivary Peptides from Anopheles albimanus as Biomarkers for Bite Exposure and Malaria Infection in Colombia." International Journal of Molecular Sciences 21, no. 3 (2020): 691. http://dx.doi.org/10.3390/ijms21030691.

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Insect saliva induces significant antibody responses associated with the intensity of exposure to bites and the risk of disease in humans. Several salivary biomarkers have been characterized to determine exposure intensity to Old World Anopheles mosquito species. However, new tools are needed to quantify the intensity of human exposure to Anopheles bites and understand the risk of malaria in low-transmission areas in the Americas. To address this need, we conducted proteomic and bioinformatic analyses of immunogenic candidate proteins present in the saliva of uninfected Anopheles albimanus fro

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Jeandel, L., E. Morrier, and S. Heisler. "Atrial natriuretic peptide stimulates submandibular gland synthesis and secretion of cGMP." American Journal of Physiology-Endocrinology and Metabolism 257, no. 5 (1989): E675—E680. http://dx.doi.org/10.1152/ajpendo.1989.257.5.e675.

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Binding of atrial natriuretic peptide (ANP) to rat submandibular gland and its effect on guanosine 3',5'-cyclic monophosphate (cGMP) formation and salivary secretion were investigated. Membranes rapidly and specifically bound 125I-ANP. Binding was inhibited by unlabeled ANP (IC50 approximately 1.6 nM), but not by atriopeptin I, other COOH- and NH2-terminal deleted ANP fragments, or agents such as pilocarpine or substance P. Scatchard analysis revealed a single class of high-affinity sites (dissociation constant 0.74 +/- 0.25 nM; maximal binding capacity 20.5 +/- 6.3 pmol/mg protein). Intraveno

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Valenzuela, Jesus G., Ivo M. B. Francischetti, Van My Pham, Mark K. Garfield, Thomas N. Mather, and José M. C. Ribeiro. "Exploring the sialome of the tick Ixodes scapularis." Journal of Experimental Biology 205, no. 18 (2002): 2843–64. http://dx.doi.org/10.1242/jeb.205.18.2843.

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SUMMARY To attempt description of the set of mRNA and protein (sialome) expressed in the salivary glands of the tick Ixodes scapularis, we randomly sequenced 735 clones of a full-length salivary gland cDNA library of this arthropod and performed Edman degradation of protein bands from salivary gland homogenates (SGH) and saliva separated by SDS-PAGE. The sequences were grouped into 410 clusters, of which 383 are not associated with known I. scapularis sequences. 15- and 17-protein bands from PAGE yielded amino-terminal information on the saliva and salivary gland gels,respectively. We attribut

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Dai, Chaobin, Bin Zhang, Yunyang Liao, et al. "CALCB rs3829222 T/T Genotype and Low Expression of CALCB Are High-Risk Factors for Adenoid Cystic Carcinoma of Salivary Gland." Disease Markers 2021 (June 12, 2021): 1–5. http://dx.doi.org/10.1155/2021/5546858.

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Objectives. To investigate the relationship between polymorphisms of calcitonin-related peptide gene II (beta-calcitonin gene-related peptide (βCGRP), CALCB) and serum CGRP levels in salivary adenoid cystic carcinoma. Materials and Methods. Using the polymerase chain reaction (PCR) technique, the full-length amplification and genotype analysis of CALCB genes were performed in 39 patients with adenoid cystic carcinoma of salivary gland and 158 normal controls. The gene frequencies of major genotype of CALCB in adenoid cystic carcinoma of salivary gland and normal control group were analyzed. En

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Alkhateeb, Alaa A., Lloyd A. Mancl, Richard B. Presland, Marilynn L. Rothen, and Donald L. Chi. "Unstimulated Saliva-Related Caries Risk Factors in Individuals with Cystic Fibrosis: A Cross-Sectional Analysis of Unstimulated Salivary Flow, pH, and Buffering Capacity." Caries Research 51, no. 1 (2016): 1–6. http://dx.doi.org/10.1159/000450658.

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Salivary flow rate, pH, and buffering capacity are associated with dental caries, but studies from the cystic fibrosis (CF) literature are inconclusive regarding these salivary factors and caries. The aim of this study was to evaluate these factors and their associations with dental caries in individuals with CF. Unstimulated whole saliva was collected from individuals aged 6-20 years at Seattle Children's Hospital CF Clinic, USA (n = 83). Salivary flow rate was measured in milliliters per minute. Salivary pH was assessed using a laboratory pH meter. Buffering capacity was assessed by titratio

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Rittschof, D., C. M. Kratt, and A. S. Clare. "Gastropod predation sites: the role of predator and prey in chemical attraction of the hermit crab Clibanarius vittatus." Journal of the Marine Biological Association of the United Kingdom 70, no. 3 (1990): 583–96. http://dx.doi.org/10.1017/s0025315400036602.

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Gastropod shells are essential to most hermit crabs. Shell availability limits hermit crab populations. Shells provide protection and the degree of shell-fit controls crab growth and fecundity. Crabs locate new gastropod shells from a distance under water by molecules released from gastropod flesh during predation events. Here we test the hypothesis that the salivary glands of the predatory gastropod are the source of enzymes that digest muscle proteins and release peptide attractants. We describe the anatomy of both the acinous salivary glands and the tubular accessory salivary glands of Busy

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Ahmed, Araz, Alessandro Gulino, Simita Amayo, et al. "Natriuretic peptide system expression in murine and human submandibular salivary glands: a study of the spatial localisation of ANB, BNP, CNP and their receptors." Journal of Molecular Histology 51, no. 1 (2019): 3–13. http://dx.doi.org/10.1007/s10735-019-09849-5.

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Abstract The natriuretic peptide (NP) system comprises of three ligands, the Atrial Natriuretic Peptide (ANP), Brain Natriuretic peptide (BNP) and C-type Natriuretic peptide (CNP), and three natriuretic peptide receptors, NPRA, NPRB and NPRC. Here we present a comprehensive study of the natriuretic peptide system in healthy murine and human submandibular salivary glands (SMGs). We show CNP is the dominant NP in mouse and human SMG and is expressed together with NP receptors in ducts, autonomic nerves and the microvasculature of the gland, suggesting CNP autocrine signalling may take place in s

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Belstrøm, Daniel, Rosa R. Jersie-Christensen, David Lyon, et al. "Metaproteomics of saliva identifies human protein markers specific for individuals with periodontitis and dental caries compared to orally healthy controls." PeerJ 4 (September 14, 2016): e2433. http://dx.doi.org/10.7717/peerj.2433.

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BackgroundThe composition of the salivary microbiota has been reported to differentiate between patients with periodontitis, dental caries and orally healthy individuals. To identify characteristics of diseased and healthy saliva we thus wanted to compare saliva metaproteomes from patients with periodontitis and dental caries to healthy individuals.MethodsStimulated saliva samples were collected from 10 patients with periodontitis, 10 patients with dental caries and 10 orally healthy individuals. The proteins in the saliva samples were subjected to denaturing buffer and digested enzymatically

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Helmerhorst, Eva J., Ingrid M. Reijnders, Wim van ’t Hof, Ina Simoons-Smit, Enno C. I. Veerman, and Arie V. Nieuw Amerongen. "Amphotericin B- and Fluconazole-ResistantCandida spp., Aspergillus fumigatus, and Other Newly Emerging Pathogenic Fungi Are Susceptible to Basic Antifungal Peptides." Antimicrobial Agents and Chemotherapy 43, no. 3 (1999): 702–4. http://dx.doi.org/10.1128/aac.43.3.702.

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ABSTRACT The present study shows that a number of basic antifungal peptides, including human salivary histatin 5, a designed histatin analog designated dhvar4, and a peptide from frog skin, PGLa, are active against amphotericin B-resistant Candida albicans,Candida krusei, and Aspergillus fumigatusstrains and against a fluconazole-resistant Candida glabrata isolate.

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Ghamari, Mahboob, Vahid Hosseininaveh, Ali Darvishzadeh, and Khalil Talebi. "Biochemical characterisation of the tissue degrading enzyme, collagenase, in the spined soldier bug, Podisus maculiventris (Hemiptera: Pentatomidae)." Journal of Plant Protection Research 54, no. 2 (2014): 164–70. http://dx.doi.org/10.2478/jppr-2014-0026.

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Abstract Podisus maculiventris (Say) is a generalist predator attacking many insect species from different orders. The bug injects saliva into its prey's body. The ingested hemolymph and liquefied internal tissues pass through the bug's alimentary tract. Collagenase working on peptide bonds of collagen and basement membrane proteins, leads to the disintegration of the prey's internal organs. As yet, there is an almost complete lack of knowledge on the collagenase activity in P. maculiventris. The collagenase activity of the salivary glands and midgut was optimum at pH 8.0 which was congruent w

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Gohel, Vishal, Judith A. Jones, and Carolyn J. Wehler. "Salivary biomarkers and cardiovascular disease: a systematic review." Clinical Chemistry and Laboratory Medicine (CCLM) 56, no. 9 (2018): 1432–42. http://dx.doi.org/10.1515/cclm-2017-1018.

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Abstract Background: The purpose of this systematic review is to summarize the literature examining associations between salivary biomarkers and cardiovascular disease (CVD) status. Contents: An advanced search was conducted using MeSH terms related to salivary biomarkers and CVD, and entered into the PubMed, Web of Science, and Google Scholar search databases. Four hundred and thirty-three records were narrowed to 22 accepted articles. Included titles were assessed for quality using the Newcastle-Ottawa scale, and ranked into categories of low, moderate, or high. Summary: A total of 40 saliva

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Armistead, Jennifer S., Iain B. H. Wilson, Toin H. van Kuppevelt, and Rhoel R. Dinglasan. "A role for heparan sulfate proteoglycans in Plasmodium falciparum sporozoite invasion of anopheline mosquito salivary glands." Biochemical Journal 438, no. 3 (2011): 475–83. http://dx.doi.org/10.1042/bj20110694.

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HS (heparan sulfate) has been shown to be an important mediator of Plasmodium sporozoite homing and invasion of the liver, but the role of this glycosaminoglycan in mosquito vector host–sporozoite interactions is unknown. We have biochemically characterized the function of AgOXT1 (Anopheles gambiae peptide-O-xylosyltransferase 1) and confirmed that AgOXT1 can modify peptides representing model HS and chondroitin sulfate proteoglycans in vitro. Moreover, we also demonstrated that the mosquito salivary gland basal lamina proteoglycans are modified by HS. We used RNA interference-mediated knockdo

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Sekine, Shinichi, Kosuke Kataoka, Muneo Tanaka, et al. "Active domains of salivary statherin on apatitic surfaces for binding to Fusobacterium nucleatum cells." Microbiology 150, no. 7 (2004): 2373–79. http://dx.doi.org/10.1099/mic.0.27107-0.

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Fusobacterium nucleatum can bind to saliva-coated tooth surfaces. However, the nature of the domains of salivary protein that interact with F. nucleatum remains unclear. The ability of individual proteins in human submandibular-sublingual saliva (HSMSL) to bind F. nucleatum cells was examined by dot blot assay; statherin displayed the strongest binding activity. Statherin binding sites were determined based on binding of 125I-labelled F. nucleatum to statherin-coated hydroxyapatite (sHAP) beads via inhibition assays using synthetic analogous peptide fragments of whole statherin. Analogous pept

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Floden, Angela M., Mona Sohrabi, Suba Nookala, Jay J. Cao та Colin K. Combs. "Salivary Aβ Secretion and Altered Oral Microbiome in Mouse Models of AD". Current Alzheimer Research 17, № 12 (2021): 1133–44. http://dx.doi.org/10.2174/1567205018666210119151952.

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Background: Beta amyloid (Aβ) peptide containing plaque aggregations in the brain are a hallmark of Alzheimer’s Disease (AD). However, Aβ is produced by cell types outside of the brain suggesting that the peptide may serve a broad physiologic purpose. Objective: Based upon our prior work documenting expression of amyloid β precursor protein (APP) in intestinal epithelium we hypothesized that salivary epithelium might also express APP and be a source of Aβ. Methods: To begin testing this idea, we compared human age-matched control and AD salivary glands to C57BL/6 wild type, AppNL-G-F , and APP

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Ryan, J., T. Mantle, S. McQuaid, and D. C. Costigan. "Salivary insulin-like growth factor-I originates from local synthesis." Journal of Endocrinology 135, no. 1 (1992): 85—NP. http://dx.doi.org/10.1677/joe.0.1350085.

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ABSTRACT Insulin-like growth factor-I (IGF-I) is a GH-dependent growth factor found in its highest concentrations in plasma. It is also measurable in saliva. The origins of salivary IGF-I concentrations were studied. Intracardial administration of Sprague–Dawley rats with 125I-labelled IGF-I and subsequent analysis of plasma and saliva samples by exclusion gel chromatography and SDS-PAGE, followed by autoradiography, demonstrated the apparent inability of IGF-I to cross from the plasma pool through to saliva. 125I-Labelled IGF-I was not chromatographed immediately before injection, resulting i

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