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Journal articles on the topic 'Salivary substitute'

Author: Grafiati

Published: 24 August 2024

Last updated: 31 July 2025

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1

V., Nekemiya, Tapan Kumar Giri, Debabrata Biswas, et al. "SALIVARY RESERVOIR IN MAXILLARY COMPLETE DENTURE- A CASE REPORT." International Journal of Advanced Research 13, no. 05 (2025): 1193–98. https://doi.org/10.21474/ijar01/21010.

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In complete denture prosthesis,saliva plays an important rolebecause it provides retention and comfortto the patient.In reduced salivary conditions, the oral mucous membranes may develop erythema and sore spots, and the patient may feel discomfort when dentures are in function. Hence, salivary substitutes are prescribed for symptomatic treatment. One efficient way to ensure slow and continuous release of salivary substitute is to incorporate a salivary reservoir in the denture. This will facilitate the lubrication of the oral environment, and aid in success of the prosthesis. This case report

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2

Sari, Dina Keumala, Liza Meutia Sari, Lidya Imelda Laksmi, et al. "Serumal and Salivary 25(OH)D and 1,25(OH)D Levels of Head and Neck Cancer Patients." Indonesian Biomedical Journal 13, no. 4 (2021): 438–43. http://dx.doi.org/10.18585/inabj.v13i4.1726.

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BACKGROUND: Saliva has been suggested as a substitute of serum for the detection of 25 Dihydroxyvitamin D (25(OH)D) in healthy people. However, investigation of salivary 1,25(OH)D has not been clearly reported. Vitamin plays important roles in inhibiting cancer progression. Current study was conducted to investigate serumal and salivary 25(OH)D) and 1,25(OH)D levels of healthy and head and neck cancer (HNC) subjects.METHODS: Research were conducted at Haji Adam Malik Hospital, Medan, Indonesia. Forty HNC and 40 healthy subjects were recruited and selected based on inclusion and exclusion crite

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Cokro, Ingrid Aurelia Genacia, Dewi Priandini, Deviyanti Pratiwi, and Akhmad Endang Zainal Hasan. "The effect of trigona spp. Propolis extract to saliva substitute ph as xerostomia therapy." Odonto : Dental Journal 10, no. 1 (2023): 117. http://dx.doi.org/10.30659/odj.10.1.117-124.

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Background: Patients with xerostomia generally have an acidic salivary pH. Low oral pH increases the occurrence of tooth caries and development of oral lesions such as recurrent aphthous stomatitis (RAS) which are prone to occur in patients with xerostomia. Trigona spp. propolis extract with antimicrobial compounds was used as an additional natural ingredient in saliva substitute to inhibit the growth of Streptococcus mutans and prevent the decrease of salivary pH in patients with xerostomia. This study aimed to determine the effect of Trigona spp. propolis extract to saliva substitute pH as t

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Porangaba, Letícia Pacheco, Flávio de Melo Garcia, Ana Paula Alvarenga Antonio Rabelo, et al. "Randomized Double-Blind Placebo-Controlled Study of Salivary Substitute with Enzymatic System for Xerostomia in Patients Irradiated in Head and Neck Region." Current Oncology 31, no. 2 (2024): 1102–12. http://dx.doi.org/10.3390/curroncol31020082.

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This study aims to compare whether the use of a salivary substitute including an enzymatic system clinically reduces the intensity of xerostomia, as well as exploring the impact that this has on the quality of life, in patients who had received radiotherapy in the head and neck (HNC) region. Forty patients who had completed radiotherapy treatment within 6 months to 1 year previously were allocated into an Enzymatic Spray group (n = 21) or a Placebo arm (n = 19). It should be noted that two patients in the Placebo arm declined to participate during phase 2 of the study. All patients were random

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Sushanthi S, Leelavathi L, Meignana Arumugham Indiran, Pradeep Kumar Rathinavelu, and Rajesh Kumar S. "Assessing the effect of natural sweetener on salivary pH and streptococcus mutans growth- An invivo study." International Journal of Research in Pharmaceutical Sciences 11, no. 4 (2020): 7799–804. http://dx.doi.org/10.26452/ijrps.v11i4.3975.

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Stevia is a natural sweetener which is used as a sugar substitute. It has been suggested that Stevia may be anti-cariogenic. However, there is limited research in this regard. Currently, Stevia rebaudiana, a plant is considered to be a suitable replacement of sugar which is healthy and has much fewer side effects than other sweeteners. To assess the salivary pH and streptococcus mutans growth among the participants after mouth rinsing with water containing natural sweetener. This double-blinded parallel clinical trial was done among forty female participants aged 22-25 years. Study participant

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Sushanthi S, Leelavathi L, Meignana Arumugham Indiran, Pradeep Kumar Rathinavelu, and Rajesh Kumar S. "Assessing the effect of natural sweetener on salivary pH and streptococcus mutans growth- An invivo study." International Journal of Research in Pharmaceutical Sciences 12, no. 1 (2021): 180–85. http://dx.doi.org/10.26452/ijrps.v12i1.3975.

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Stevia is a natural sweetener which is used as a sugar substitute. It has been suggested that Stevia may be anti-cariogenic. However, there is limited research in this regard. Currently, Stevia rebaudiana, a plant is considered to be a suitable replacement of sugar which is healthy and has much fewer side effects than other sweeteners. To assess the salivary pH and streptococcus mutans growth among the participants after mouth rinsing with water containing natural sweetener. This double-blinded parallel clinical trial was done among forty female participants aged 22-25 years. Study participant

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7

Pathania, Neha, Sabat Un Noor, Rahul Kumar, Archana Nagpal, and Rajeev Gupta. "An ingenious technique for functional palatal reservoir construction in complete dentures." IP Annals of Prosthodontics and Restorative Dentistry 7, no. 4 (2021): 195–99. http://dx.doi.org/10.18231/j.aprd.2021.039.

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The retention, stability and comfort of wearing denture is greatly influenced by the flow, quantity and consistency of saliva. Insufficient salivary output results especially in old-aged edentulous patients may result in denture sores because of lack of lubrication by saliva, thus, reducing patient’s ability to retain the prosthesis. Various approaches have been concernes with the use of reservoir with holes have been described in the literature. However the flow of salivary substitute is very difficult to control. Moreover the frequent cleaning of the denture required to maintain the patency

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8

Bharanija, K. S., V. Ashok, and Anandapandian Ponsekar Abraham. "An innovative technique for palatal reservoir construction in complete dentures: A case report." Journal of Dental Research, Dental Clinics, Dental Prospects 12, no. 3 (2018): 227–31. http://dx.doi.org/10.15171/joddd.2018.035.

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The retention and comfort of wearing prosthesis mainly depends on saliva. In reduced saliva conditions, such as xerostomia or radiation therapy, the oral mucosa tends to become dry and ulcerated, leading to the patient's inability to retain the prosthesis. Various techniques have been reported in the literature regarding the use of a reservoir with holes in dentures. The results have not been satisfactory because the flow of the salivary substitute could not be controlled and with frequent cleaning of the denture being necassary to maintain the patency of the reservoir holes. A newer technique

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9

Ibarra, M., Marta Vázquez, P. Fagiolino, F. Mutilva, and A. Canale. "Total, unbound plasma and salivary phenytoin levels in critically ill patients." Journal of Epilepsy and Clinical Neurophysiology 16, no. 2 (2010): 69–73. http://dx.doi.org/10.1590/s1676-26492010000200006.

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OBJECTIVE: To assess the reliability of salivary phenytoin (PHT) concentrations and predicted free PHT levels by Sheiner-Tozer equation in order to substitute measured free PHT concentrations in critically ill patients. METHODOLOGY: Twenty-four neurocritically ill adult patients receiving intravenous PHT were included in the study. Analyses of total, free plasma and saliva PHT concentrations were performed by fluorescence polarization immunoassay. Plasma albumin levels were also determined. RESULTS: Free PHT concentrations as well as salivary levels better correlate to clinical effect than tot

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10

Honceriu, Cezar, Mihai Roca, Alexandru Dan Costache, et al. "Blood and Salivary Cortisol Variations in Athletes in Relation to Cardiopulmonary Exercise Testing." Medicina 59, no. 10 (2023): 1726. http://dx.doi.org/10.3390/medicina59101726.

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Background and Objectives: Cortisol is a valuable marker for assessing the body’s response to any form of stress. We conducted this study in order to evaluate the variations of salivary and serum cortisol levels in professional football players in relation to cardiopulmonary exercise testing (CPET) and their significance in potentially evaluating overtraining in athletes. Also, the question of whether salivary cortisol determination could fully substitute serum sampling was addressed. Materials and Methods: A total of 19 male professional football players were evaluated by measuring serum cort

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11

Li, Jin, Shenghua Chang, Haiying Guo, et al. "Altered Salivary Microbiome in the Early Stage of HIV Infections among Young Chinese Men Who Have Sex with Men (MSM)." Pathogens 9, no. 11 (2020): 960. http://dx.doi.org/10.3390/pathogens9110960.

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Human immunodeficiency virus (HIV) infections are spiking in Chinese young men who have sex with men (MSM). To explore alterations in the salivary microbiome and its correlation with demographic characteristics, CD4+ T cell count and viral load (VL) in HIV infections, samples of unstimulated whole saliva were analyzed by 16S rRNA gene sequencing using the Illumina MiSeq platform in 20 HIV newly infected patients before the initiation of antiretroviral therapy (ART) and at three and six months after, and in 20 age- and gender-paired healthy Chinese people. The results showed that the alpha dive

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12

Sari, Dina Keumala, Liza Meutia Sari, Lidya Imelda Laksmi, and Farhat Farhat. "The Use of 25-hydroxyvitamin D Saliva Test to Replace Vitamin D Serum Blood Test in Healthy People." Open Access Macedonian Journal of Medical Sciences 9, T3 (2021): 40–43. http://dx.doi.org/10.3889/oamjms.2021.6329.

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BACKGROUND: Routine examination of Vitamin D levels is carried out by checking serum 25-hydroxyvitamin D (25[OH]D) levels which indicate circulating Vitamin D levels. While serum 1.25(OH)D levels are less frequently performed, although serum 1.25(OH)D levels represent the active form of Vitamin D be a substitute for checking Vitamin D levels. AIMS: This study aims to see the correlation between Vitamin D levels, namely, 25(OH)D and 1.25(OH)D saliva, which correlate with serum 25(OH)D and 1.25(OH)D levels so that the examination of salivary Vitamin D levels can be a substitute for checking seru

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13

Chandrasekar, Muthulakshmi, Bose Divya, Madhu Narayan, V. Vasanthi, A. Ramesh Kumar, and Krishnan Rajkumar. "Saliva as a Diagnostic Biomarker in Postmenopausal Women: A Systematic Review." Journal of Datta Meghe Institute of Medical Sciences University 19, no. 3 (2024): 421–26. http://dx.doi.org/10.4103/jdmimsu.jdmimsu_130_23.

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Abstract Background: The main health problems faced by postmenopausal women include osteoporosis, vasomotor symptoms, cardiovascular diseases, urogenital atrophy, cancer, psychiatric symptoms, and cognitive problems. These manifestations can lead to postmenopausal syndrome, and the management of these manifestations has become a prime area of investigation in recent times. Aim: The aim of this systematic review is to critically analyze the literature to identify the salivary markers that can be used to diagnose diseases in postmenopausal women. Materials and Methods: Articles related to saliva

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14

Meulenberg, P. M., and J. A. Hofman. "Salivary progesterone excellently reflects free and total progesterone in plasma during pregnancy." Clinical Chemistry 35, no. 1 (1989): 168–72. http://dx.doi.org/10.1093/clinchem/35.1.168.

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Abstract To see if saliva is a valid substitute for plasma in assay of progesterone even when concentrations of hormone and binding proteins are fluctuating, we determined the concentrations of total and free progesterone in plasma and salivary progesterone in specimens from 36 women volunteers during the course of pregnancy and six weeks postpartum, using a highly specific RIA for total progesterone after extraction and chromatographic purification of the steroid. The free fraction in plasma was determined via equilibrium dialysis, followed by the same RIA analysis for progesterone in the dia

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15

Pilbrow, W. J., S. M. Brownless, J. I. Cawood, A. Dynes, J. D. Hughes, and H. R. Stockdale. "Salivary gland scintigraphy—a suitable substitute for sialography?" British Journal of Radiology 63, no. 747 (1990): 190–96. http://dx.doi.org/10.1259/0007-1285-63-747-190.

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16

Calvert, N., F. Cutts, R. Irving, D. Brown, J. Marsh, and E. Miller. "Measles immunity and response to revaccination among secondary school children in Cumbria." Epidemiology and Infection 116, no. 1 (1996): 65–70. http://dx.doi.org/10.1017/s0950268800058969.

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SummaryThe prevalence of antibody to measles virus in 759 children aged 11–18 years attending a secondary school in Cumbria was measured using a salivary IgG antibody capture assay. Serum IgG antibody levels were measured using a plaque reduction neutralization assay in subjects whose saliva was antibody negative. Vaccination histories were obtained from the child health computer and general practice records. A total of 662 pupils (87 % of those tested) had detectable measles-specific IgG in saliva. Of the remaining 97, 82 provided blood samples and 29 had serum neutralizing antibody levels ab

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17

Thaweboon, Sroisiri, and Boonyanit Thaweboon. "Inhibitory Potential of Artificial Saliva Containing Vanillin against Biofilm Formation of Candida." Key Engineering Materials 907 (January 21, 2022): 91–96. http://dx.doi.org/10.4028/www.scientific.net/kem.907.91.

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Saliva plays a crucial role in oral health. Reduced salivary flow (hyposalivation) and xerostomia (dry mouth) are commonly found in many groups of patients, such as cancer patients with head and neck radiotherapy, patients taking medications with antisialogogic effects, diabetic patients, autoimmune patients, and the elderly. When salivary function is diminished, there is more risk of patients to develop opportunistic infections. One of therapeutic methods to restore lost or improve existing functions of natural saliva is the use of saliva substitutes. Several types of salivary substitutes hav

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Pavlov, Niкolai, Ivelina Popova-Sotirova, Nina Musurlieva, et al. "Influence of Ordinary Cigarettes and Their Substitute IQOS® on Secretory Immunoglobulin A in Unstimulated Saliva." Dentistry Journal 13, no. 7 (2025): 297. https://doi.org/10.3390/dj13070297.

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Background: Secretory immunoglobulin A (sIgA) plays a key role in oral and mucosal immunity, serving as a first-line defense against pathogens. Smoking is known to negatively affect immune function, but data on the impact of heated tobacco products such as IQOS® on sIgA levels are limited. Objective: To assess and compare the effects of conventional cigarette smoking and IQOS® use on the concentration of salivary sIgA in healthy individuals. Methods: A total of 200 participants were enrolled and divided into three groups: 60 non-smokers, 70 conventional cigarette smokers, and 70 IQOS® users. U

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Tonetto, Mateus Rodrigues, Marcelo Ferrarezi de Andrade, José Roberto Cury Saad, et al. "Action of the Salivary Microorganisms having Sorbitol as Substratum." World Journal of Dentistry 5, no. 4 (2014): 218–22. http://dx.doi.org/10.5005/jp-journals-10015-1293.

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ABSTRACT Microorganisms living in the saliva are able to ferment some sweetener types and to promote the fall of pH that has its critical point around 5.5; in this situation, they equal the input and the calcium output in the processes of remineralization and demineralization. For iteration of the three essential factors to the installation of the dental caries (microorganism, host and diet) suggested the accomplishment of a work that involved one of these factors. This work aims to study this issue, through the indication of substitute sweetener of the saccharose, whenever possible, it solved

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Tanushri, MD Puja CY. "EFFECT OF MOUTH RINSING WITH SOLUTIONS CONTAINING DIFFERENT COMMERCIALLY AVAILABLE SUGAR SUBSTITUTES ON SALIVARY PH- AN IN VIVO RANDOMIZED CONTROLLED TRIAL." Indian Journal of Medical Research and Pharmaceutical Sciences 4, no. 5 (2017): 6–14. https://doi.org/10.5281/zenodo.572580.

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<strong>Background:</strong> Nowadays sugar free food and drinks have become very popular because of increased concerns related to obesity and overweight; as it is well known that sucrose has a negative impact on both general as well as oral health. These artificial sweeteners also have some side-effects when consumed in excess. In recent decade, stevia rebaudiana, a plant derived sugar is considered as a natural and healthy alternative to sugar and artificial sweeteners. Literature pertaining to the salivary pH changes related to stevia is limited. <strong>Objective:</strong> to assess the ef

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Mazko, Olesya N., Valentina M. Vorobyeva, Oksana E. Shishkina, et al. "TOXICITY STUDY OF MOISTURIZING ANTIXEROSTOMY GEL DURING SINGLE ADMINISTRATION." Bulletin of Medical Science 36, no. 4 (2024): 118–25. https://doi.org/10.31684/25418475-2024-4-118.

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Introduction. In clinical practice, xerostomia, or dry mouth (ICD 10 - K 11.7), is a chronic disease that usually develops against a background of hyposalivation, when salivary secretion is reduced to 50-60%, but can also occur with normal salivary secretion, but with a violation of ratio of components of the salivary gland secretion. The causes of xerostomia are due to many medical problems and factors. Xerostomia syndrome complicates the development of dental diseases, leads to tooth loss, which ultimately significantly reduces the quality of life of patients. Regardless of the cause of the

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Alemrajabi, Mohammad-Sadegh, Azam Dadkhah, Seyed-Ali Kasayizadegan-Mahabadi, and Maryam-Sadat Sadrzadeh-Afshar. "Serum and Salivary Levels of Glucose and Urea in Pregnant and Non-pregnant Women: A Comparative Study." Disease and Diagnosis 10, no. 4 (2021): 164–68. http://dx.doi.org/10.34172/ddj.2021.29.

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Background: Pregnancy is one of the most critical periods in the life of most women. Since it is necessary to be aware of the health of the mother and fetus, serum markers (i.e., glucose and urea) need to be monitored during pregnancy. A routine strategy in this area is venipuncture which is applied to measure the level of these markers. It is also a stressful procedure for pregnant women. The purpose of this study was to determine the salivary level of these markers as a stress-free method in pregnant women. Materials and Methods: The samples were collected from 30 pregnant and 30 non-pregnan

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Okumura, Kenji, Masanori Shinohara, and Fumio Endo. "Capability of Tissue Stem Cells to Organize into Salivary Rudiments." Stem Cells International 2012 (2012): 1–11. http://dx.doi.org/10.1155/2012/502136.

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Branching morphogenesis (BrM), an essential step for salivary gland development, requires epithelial-mesenchymal interactions. BrM is impaired when the surrounding mesenchyme is detached from the salivary epithelium during the pseudoglandular stage. It is believed that the salivary mesenchyme is indispensable for BrM, however, an extracellular matrix gel with exogenous EGF can be used as a substitute for the mesenchyme during BrM in the developing salivary epithelium. Stem/progenitor cells isolated from salivary glands in humans and rodents can be classified as mesenchymal stem cell-like, bone

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Sari, Dina Keumala, Liza Meutia Sari, and Lidya Imelda Laksmi. "The use of 25(OH)D saliva test as a substitute for 25(OH)D serum test in healthy people." World Nutrition Journal 4, no. 1-3 (2020): 39. http://dx.doi.org/10.25220/wnj.v04.s3.0027.

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Background and Objectives: Examination of serum 25(OH)D levels of vitamin D in the body circulation illustrates the level of circulating vitamin D, while serum 1.25(OH)D is used to describe vitamin D activity. Several studies have shown that there is a non-invasive test that can be done to check vitamin D levels, namely through salivary levels. This study aims to determine the ratio between serum 25(OH)D and 1.25(OH)D serum levels and to compare the levels in saliva.Methods: This study was a cross-sectional study that included 36 healthy people, male and female, aged 18-35 years old, living in

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Bhushan, Prem, Menas A. Aras, Vidya Chitre, Ivy Coutinho, Aradhana Nagarsekhar, and Ashwin Mysore. "Salivary reservoir designs for patients with xerostomia: a review." Journal of Research in Dentistry 4, no. 2 (2016): 51. http://dx.doi.org/10.19177/jrd.v4e2201651-57.

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Aim: The present paper aims to review the literature available on various approaches to salivary reservoir designs, the functional aspects, cleansibility, type of attachments used, and different techniques used for the fabrication of salivary reservoirs in patients suffering from xerostomia.Material and Methods: A search in the National Library of Medicine’s Pub Med database, Google search and Science Direct was performed to include all case reports and reviews on prosthodontic rehabilitation of dentulous/partially edentulous/edentulous patient with xerostomia.Results: Out of the 35 articles f

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Nogawa, H., and Y. Takahashi. "Substitution for mesenchyme by basement-membrane-like substratum and epidermal growth factor in inducing branching morphogenesis of mouse salivary epithelium." Development 112, no. 3 (1991): 855–61. http://dx.doi.org/10.1242/dev.112.3.855.

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Mouse salivary epithelium cannot undergo branching morphogenesis in the absence of the surrounding mesenchyme. To clarify the nature of the mesenchymal influence on the epithelium, we have investigated the culture conditions in which the epithelium could normally branch in the absence of mesenchymal cells. Combination of basement-membrane-like substratum (Matrigel) and epidermal growth factor (EGF) could substitute for the mesenchyme, the epithelium showing typical branching morphogenesis. Transforming growth factor alpha had the same effect as EGF. Matrigel plus basic fibroblast growth factor

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Istiati and Esa Ilham Mei Sasmita. "Saliva-Based Test as an Alternative Diagnosis for SARS-CoV-2 Patient." Dentika: Dental Journal 26, no. 1 (2023): 60–66. http://dx.doi.org/10.32734/dentika.v26i1.9843.

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Respiratory system is affected by a novel type of virus known as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The gold standard for its identification is the real-time reverse transcription polymerase chain reaction (rRT-PCR) test, despite being invasive and dangerous to medical workers during the sample-collecting process. However, major salivary glands including the parotid, submandibular, and sublingual, as well as smaller glands dispersed throughout the mouth cavity, release saliva, a hypotonic fluid, containing biomarkers that can be used to identify both local and system

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Kafi, Md Abdullah Hel, Md Arif Hossain Bhuyan, Md Jahangir Hossain Bhuiyan, and MS Khurshid Alam. "Management of salivary gland neoplasm study of 32 cases." Bangladesh Journal of Medical Science 9, no. 2 (2010): 87–94. http://dx.doi.org/10.3329/bjms.v9i2.5656.

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Objective: To study the clinical, radiological and histopathological characteristics along with the management outcome of salivary gland neoplasm. Materials and Methods: This study included thirty two patients (16 male and 16 female) with salivary gland tumours presented at Combined Military Hospital Dhaka, Apollo Hospital Dhaka and Ibn Sina Medical College and Hospital Dhaka from January 2006 to December 2009. The data of each patient included age, sex, presenting symptoms and signs, provisional diagnosis, preoperative investigations, operation notes, histopathological examination and state a

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Semmler, Marion, Bogac Tur, Ludger Schlautmann, et al. "Analysis of potential influencing factors for acoustic quality in patients with ectodermal dysplasia." Journal of the Acoustical Society of America 155, no. 3_Supplement (2024): A340. http://dx.doi.org/10.1121/10.0027749.

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Subjects with ectodermal dysplasia (ED) suffer from an inherited disorder in the development of ectodermal structures. They show a significantly reduced formation of teeth, hair, and a reduced number and activity of sweat and salivary glands. Recently, the voice of ED subjects has come into focus. It is assumed that the generally reduced glandular function is responsible for the altered vocal sound, although no specific cause has been identified. Previous findings included significant changes in the acoustic quality, the parameters derived from high-speed videoendoscopy, the laboratory analysi

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Lee, S. I., and R. J. Turner. "Secretagogue-induced 86Rb+ efflux from bovine parotid is HCO3- dependent." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 264, no. 1 (1993): R162—R168. http://dx.doi.org/10.1152/ajpregu.1993.264.1.r162.

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Muscarinic agonist (carbachol)-induced K+ loss from a bovine parotid mince was studied using 86Rb+ as a K+ marker. In contrast to our previous studies with the rat parotid [Am. J. Physiol. 261 (Gastrointest. Liver Physiol. 24): G111-G118, 1991] in which both Cl(-)-dependent and HCO3(-)-dependent components of carbachol-induced 86Rb+ efflux were observed, no significant evidence for Cl(-)-dependent 86Rb+ loss was detected in the bovine parotid. HCO3(-)-dependent agonist-induced 86Rb+ loss was blunted by K+ and Cl- channel blockers and by removal of extracellular Ca2+, consistent with the hypoth

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31

Pinni, Jyothsna, J. S. Sankar Avula, Sridhar Mukthineni, Sujatha Bandi, and Thulasi Gokul. "Evaluation of Anticariogenic Efficacy of Pomegranate (Punica Granatum) Pericarp Extract as Natural Mouth Rinse: An In Vitro and In Vivo Study." Biomedical and Pharmacology Journal 11, no. 4 (2018): 2025–30. http://dx.doi.org/10.13005/bpj/1578.

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Plant materials were known as source of new antimicrobial agents. Many efforts have been made to develop alternative mouth rinses from natural products which are safe, easily available and substitute the standard pharmaceutical remedies. Thus, considering the therapeutic value of pomegranate fruit, the present study was designed to compare the antimicrobial efficacy of aqueous extract of Pomegranate pericarp and commercially available Chlorhexidine mouth wash against caries causative microorganisms both in vitro and in vivo. To evaluate the antimicrobial efficacy of pomegranate pericarp extrac

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Alkhayoun, Juman Dhia. "The Effect of Xylitol on the Antimicrobial Activity of Chlorhexidine Against Mutans Streptococci and Lactobacilli." South Asian Research Journal of Oral and Dental Sciences 7, no. 02 (2025): 41–46. https://doi.org/10.36346/sarjods.2025.v07i02.007.

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Background: Dental caries continues to be a major public health problem in many countries. The etiology of dental caries is multifactorial, and it is widely accepted that Mutans streptococci and Lactobacilli play a major role in the formation of dental caries through adhering to the tooth surface and producing acid from dietary sucrose. Chlorhexidine is active against both gram positive and negative bacteria and Xylitol is a naturally occurring non-cariogenic sugar substitute used as an artificial sweetener in foods, Objective: The purpose of this study was to determine the impact of xylitol o

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Levine, M. J., A. Aguirre, M. N. Hatton, and L. A. Tabak. "Artificial Salivas: Present and Future." Journal of Dental Research 66, no. 1_suppl (1987): 693–98. http://dx.doi.org/10.1177/00220345870660s115.

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Modern technology has allowed us to understand better the functions of saliva and now provides a rationale for developing: (1) diagnostic reagents for monitoring oral and systemic health status and (2) replacement therapies for individuals with salivary dysfunctions. Several areas of dental research are directed at augmenting or enhancing both the quality and quantity of saliva for individuals with dry mouth. An “intrinsic” approach is being explored which utilizes medications such as pilocarpine and bromhexine to stimulate the salivary glands to produce more saliva. An “extrinsic” approach pr

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Levine, M. J., A. Aguirre, M. N. Hatton, and L. A. Tabak. "Artificial Salivas: Present and Future." Journal of Dental Research 66, no. 2_suppl (1987): 693–98. http://dx.doi.org/10.1177/00220345870660s215.

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Modern technology has allowed us to understand better the functions of saliva and now provides a rationale for developing: (1) diagnostic reagents for monitoring oral and systemic health status and (2) replacement therapies for individuals with salivary dysfunctions. Several areas of dental research are directed at augmenting or enhancing both the quality and quantity of saliva for individuals with dry mouth. An “intrinsic” approach is being explored which utilizes medications such as pilocarpine and bromhexine to stimulate the salivary glands to produce more saliva. An “extrinsic” approach pr

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Oganesiants, Ekaterina, Varuzhan Sarkisyan, Anastasiya Bilyalova, Vasily Isakov, and Alla Kochetkova. "The Role of Bitter-Tasting Substances in Salivation and Swallowing: Results of the Pilot Study." Foods 14, no. 2 (2025): 210. https://doi.org/10.3390/foods14020210.

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The aim of this study was to investigate the effects of caffeine, vanillin, and epigallocatechin gallate on salivation and swallowing and to find ways to correct their negative effects. Solutions of these substances with an equivalent intensity of bitter taste were compared for this purpose. To compensate for their effect, solutions of adenosine monophosphate, saliva substitute, and their combination were used. The results of the sialometric and surface electromyographic analyses demonstrate that all of the bitter substances studied exert a significant influence on the physiology of salivation

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Łysik, Dawid, Katarzyna Niemirowicz-Laskowska, Robert Bucki, Grażyna Tokajuk, and Joanna Mystkowska. "Artificial Saliva: Challenges and Future Perspectives for the Treatment of Xerostomia." International Journal of Molecular Sciences 20, no. 13 (2019): 3199. http://dx.doi.org/10.3390/ijms20133199.

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The chronic sensation of a dry mouth is a disease condition called xerostomia and affects a large part of the population. Xerostomia is associated with decreased secretion, or more often, qualitative changes in saliva proteins and immunoglobulin concentrations that develop as a result of salivary gland dysfunction. Several reasons causing dry mouth were described, and usually, they include taking medications, diseases or radiotherapy. In some situations, when it is difficult to use salivary stimulants or salivary gland damage is irreversible, the only option might seem to be saliva substitutes

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Vinke, Jeroen, Hans J. Kaper, Arjan Vissink, and Prashant K. Sharma. "Dry mouth: saliva substitutes which adsorb and modify existing salivary condition films improve oral lubrication." Clinical Oral Investigations 24, no. 11 (2020): 4019–30. http://dx.doi.org/10.1007/s00784-020-03272-x.

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Abstract Objectives The aims of this study are to assess different saliva substitutes for their efficacy to lubricate the oral cavity, and to relate this oral lubrication to the ability of saliva substitutes to adsorb on and change the structure of the existing salivary conditioning film (SCF). Materials and methods Quartz crystal microbalance with dissipation was used to study the capability of saliva substitutes to interact with natural SCF and the ability to change the secondary SCF (S-SCF). A tongue-enamel friction system mimicking xerostomic conditions was used to assess the relief and re

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M.S, Serene, Shipra Jaidka, Rani Somani, et al. "NONFLUORIDATED REMINERALIZING AGENTS." International Journal of Advanced Research 10, no. 09 (2022): 618–26. http://dx.doi.org/10.21474/ijar01/15400.

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Early diagnosis of dental caries is of paramount importance. If we are able to intercept caries lesion at subsurface level with the help of remineralizing agents, we can actually achieve a caries free mouth.Remineralization was ruled by fluorides from the 1960s. Since then it has been successfully remineralizing carious lesions & has certain disadvantages like it is dependant on calcium and phosphate from saliva to accomplish this. Also overuse of fluorides can cause dental and skeletal fluorosis. This made researchers to explore nonfluoridated remineralizing agents.ACP compounds are consi

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Ghorbani Behnam, Shahram, Seyed Abbas Mousavi, and Mohammad Hassan Emamian. "The effects of transcranial direct current stimulation compared to standard bupropion for the treatment of tobacco dependence: A randomized sham-controlled trial." European Psychiatry 60 (August 2019): 41–48. http://dx.doi.org/10.1016/j.eurpsy.2019.04.010.

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AbstractBackground:Current treatments for smoking cessation are not effective for most smokers. This study aims to examine the effectiveness of transcranial Direct Current Stimulation (tDCS) on smoking cessation.Methods:In this randomized, sham-controlled trial study, tobacco-dependent (by DSM-5) male participants were recruited from the general public invitation. Participants were randomly allocated to 5 groups; (A), treatment with 300mg bupropion for 8 weeks; (B), active tDCS (20 sessions for 4 weeks); (C), sham for group B ; (D), active tDCS (20 sessions for 12 weeks), and (E), sham for gro

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Levine, Michael J. "Development of Artificial Salivas." Critical Reviews in Oral Biology & Medicine 4, no. 3 (1993): 279–86. http://dx.doi.org/10.1177/10454411930040030401.

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Salivary research is at a critical crossroads regarding the clinical application of basic knowledge. Studies by numerous salivary researchers over the last 5 years using advanced technologies (e.g., protein chemistry, molecular biology, and biophysics) have demonstrated that the structural requirements for salivary function are quite complex. Nevertheless, several patterns or principles have evolved. First, the majority if not all salivary molecules are multifunctional. Second, the conformation of a molecule is an important factor in biological activity. Third, many molecules have overlapping

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Srisomboon, Surapong, Thanapong Intharah, Ungkarn Jarujareet, Arnit Toneluck, and Piyaphong Panpisut. "The in vitro assessment of rheological properties and dentin remineralization of saliva substitutes containing propolis and aloe vera extracts." PLOS ONE 19, no. 5 (2024): e0304156. http://dx.doi.org/10.1371/journal.pone.0304156.

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Saliva substitutes with enhanced dentin remineralization properties were expected to help manage caries progression in patients with xerostomia. This in vitro study examined the rheological properties and remineralization action of experimental saliva substitutes containing propolis extract and aloe vera extract on demineralized dentin. Four experimental saliva substitutes were formulated with varying concentrations of propolis extract (P) and aloe vera extract (A) were prepared. A commercial saliva substitute (Biotene Oral Rinse) was used as a commercial comparison. The rheological properties

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Kononchuk, Anastasia G., Vyacheslav V. Martemyanov, Anastasia N. Ignatieva, Irina A. Belousova, Maki N. Inoue, and Yuri S. Tokarev. "Susceptibility of the Gypsy Moth Lymantria dispar (Lepidoptera: Erebidae) to Nosema pyrausta (Microsporidia: Nosematidae)." Insects 12, no. 5 (2021): 447. http://dx.doi.org/10.3390/insects12050447.

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The gypsy moth, Lymantria dispar, is a notorious forest defoliator, and various pathogens are known to act as natural regulators of its population density. As a widespread herbivore with a broad range of inhabited areas and host plants, it is potentially exposed to parasitic microorganisms from other insect hosts. In the present paper, we determined the susceptibility of gypsy moth larvae to the microsporidium Nosema pyrausta from the European corn borer, Ostrinia nubilalis. Gypsy moth samples from two localities of Western Siberia were used. N. pyrausta developed infections in the salivary gl

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Niemirowicz-Laskowska, Katarzyna, Joanna Mystkowska, Dawid Łysik, et al. "Multifunctional artificial saliva preparation – challenges and needs." Postępy Polskiej Medycyny i Farmacji 8 (June 9, 2021): 37–46. http://dx.doi.org/10.5604/01.3001.0014.9199.

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Saliva plays a crucial role in maintaining homeostasis not only within the oral cavity but also in further sections of the gastrointestinal tract. Pleiotropic properties of saliva include participation in the digestion of carbohydrates, cleansing and moisturizing the oral cavity, and maintaining the composition of the oral microbiome. The result of impaired function of the salivary gland is reduced salivation – hyposalivation, leading to dry mouth – xerostomia. It is established that numerous physiological factors (age, sex, weight change) and pathological factors (polytherapy, head and neck c

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Cesar, Marcelo, Rayssa Justo, João Vidal, Maurício Bonel, Edimilson Migowski, and Rafael Cisne. "The use of drugs for the treatment of xerostomia – brief review." International Journal of Basic and Applied Sciences 5, no. 4 (2016): 238. http://dx.doi.org/10.14419/ijbas.v5i4.6708.

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Inadequate production of saliva causes an oral imbalance that has a great impact on the individual's quality of life. Diseases of various types are responsible for impaired production of saliva and dry mouth, as happens in xerostomia. It is usually associated with hypofunction of the salivary glands, which shows signs of dryness on oral mucosa, and other morphological features in the oral cavity. Saliva is composed of water and 1% of electrolytes and immunoglobulins, enzymes and other proteins. Its fluid component, which contains ions, is mainly produced by parasympathetic stimulation, while t

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Zhafirah, Nandya, Dian Lesmana, and Silvi Kintawati. "Efek Konsumsi Stevia pada pH Saliva Kelompok Dewasa Muda: Tinjauan Literatur." STOMATOGNATIC - Jurnal Kedokteran Gigi 21, no. 2 (2024): 94–101. https://doi.org/10.19184/stoma.v21i2.50938.

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The sugar intake in daily diet can lower saliva pH, potentially leading to dental caries, particularly among young adults due to frequent consumption of sweeteners in food and beverages. The application of non-nutritive sweeteners as sugar substitutes is becoming a consideration because they provide a sweet taste similar to sugar but have a non-cariogenic effect. Stevia leaves as a non-nutritive sweetener plant, are increasingly favored because they exhibit anti-cariogenic effects. In vivo study results indicate that stevia leaves can increase saliva pH. This study aims to investigate the impa

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Earar, Kamel, Alina-Ramona Dimofte, Roxana Dragan, et al. "THE ROLE OF SALIVARY GLANDS IN ORAL REHABILITATION: FUNCTIONS, IMPORTANCE, PATHOLOGY AND THERAPEUTIC APPROACHES." Romanian Journal of Oral Rehabilitation 16, no. 2 (2024): 671–80. https://doi.org/10.62610/rjor.2024.2.16.62.

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The salivary glands are essential for oral health, providing not only environments for digestion and taste, but also protection from pathogens. This review examines the functions of salivation, the importance of salivary glands in the context of oral pathology, and therapeutic approaches for their dysfunctions. Pathologies of the salivary glands range from minor conditions, such as sialadenitis, to severe conditions, such as cancer of the salivary glands. These conditions can affect quality of life, the ability to eat and speak, and have systemic implications. Treatment of salivary gland dysfu

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Jonjić, S., W. Mutter, F. Weiland, M. J. Reddehase, and U. H. Koszinowski. "Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes." Journal of Experimental Medicine 169, no. 4 (1989): 1199–212. http://dx.doi.org/10.1084/jem.169.4.1199.

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We have established a murine model system for exploring the ability of a CD4 subset-deficient host to cope with cytomegalovirus infection, and reported three findings. First, an antiviral response of the CD8 subset of T lymphocytes could be not only initiated but also maintained for a long period of time despite a continued absence of the CD4 subset, whereas the production of antiviral antibody proved strictly dependent upon help provided by the CD4 subset. Second, no function in the defense against infection could be ascribed as yet to CD4-CD8- T lymphocytes, which were seen to accumulate to

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Mercadante, Valeria, Siri Beier Jensen, Derek K. Smith, et al. "Salivary Gland Hypofunction and/or Xerostomia Induced by Nonsurgical Cancer Therapies: ISOO/MASCC/ASCO Guideline." Journal of Clinical Oncology 39, no. 25 (2021): 2825–43. http://dx.doi.org/10.1200/jco.21.01208.

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PURPOSE To provide evidence-based recommendations for prevention and management of salivary gland hypofunction and xerostomia induced by nonsurgical cancer therapies. METHODS Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) and ASCO convened a multidisciplinary Expert Panel to evaluate the evidence and formulate recommendations. PubMed, EMBASE, and Cochrane Library were searched for randomized controlled trials published between January 2009 and June 2020. The guideline also incorporated two previous systematic reviews conducted by MASC

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Nagler, R. M. "Altered Salivary Profile in Heavy Smokers and its Possible Connection to Oral Cancer." International Journal of Biological Markers 22, no. 4 (2007): 274–80. http://dx.doi.org/10.1177/172460080702200406.

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Saliva is the first biological fluid to encounter inhaled cigarette smoke, whose numerous carcinogens and oxidants are responsible for the oral cancer so prevalent among smokers. Whole saliva, collected from 25 consenting heavy smokers and from a control group of 25 age- and gender-matched non-smokers, was subjected to sialochemical, biochemical, immunological and oxidative analyses. The mean flow rate was significantly higher in smokers than in non-smokers, as were the median activity value of superoxide dismutase (SOD) and the total salivary antioxidant capacity (ImAnOx) (by 32% and 12%, res

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Schwarz, W. H. "The Rheology of Saliva." Journal of Dental Research 66, no. 1_suppl (1987): 660–66. http://dx.doi.org/10.1177/00220345870660s109.

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The rheology of saliva affects the coating and lubrication of oral surfaces and the consistency of ingested foods. Salivary gland dysfunction can cause tissue damage and dysphagia. Therefore, we have considered the problem of designing a synthetic saliva for medical management. Also, we have measured certain rheological properties [shear-dependent viscosity η (k)] and the frequency-dependent moduli [G′(f) and η′(f)] of normal stimulated whole saliva. Analysis of the rheological data and consideration of requirements for using artificial saliva have resulted in a better understanding of the rhe

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