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Dissertations / Theses on the topic 'Salvinorin A'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 August 2024

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1

LaBelle, Keri Lyn. "Development of presumptive macroscopic, microscopic, and colorimetric tests for Salvia divinorum, salvinorin A, and salvinorin B." Thesis, Boston University, 2012. https://hdl.handle.net/2144/12463.

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Thesis (M.S.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Salvia divinorum (S. divinorum) is a psychoactive plant from the Lamiaceae (mint) family originating in the Oaxaca region of Mexico. The plant's psychoactive compound, salvinorin A (sal A) has been found to be u

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2

Lingham, Anthony, and arlingham@hotmail com. "Studies Toward the Synthesis of Salvinorin A." RMIT University. Applied Sciences, 2008. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20080428.095126.

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Salvinorin A [(2S,4aR,6aR,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(3-furanyl)-dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naptho[2,1-c]pyran-7-carboxylic acid methyl ester] is a trans-neoclerodane diterpene from the leaves of the hallucinogenic Mexican sage Salvia divinorum and has been identified as the principal psychoactive component in this plant of traditional spiritual importance. Salvinorin A is the most potent naturally occurring hallucinogen found so far and is reported to act selectively as a Û-opioid receptor agonist. Synthetic modification of the natural product has contributed to a number

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3

McGovern, Donna. "Salvinorin A: Fragment Synthesis and Modeling Studies." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1862.

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Salvinorin A is a non-nitrogenous, selective kappa opioid receptor agonist with potent hallucinogenic properties. Because Salvinorin A has no basic nitrogen, it does not readily adhere to the “message-address” concept of selectivity for the opioid receptors. Therefore, a better understanding of how salvinorin A and its analogs interact with the kappa opioid receptor may shed some light on how salvinorin A obtains its potency and selectivity. The structure-affinity relationships (SAFIR) of salvinorin A and its analogs along with a discussion of the selectivity of the opioid receptors, is pre

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4

Butler, Sean Colin. "Construction of the Carbon Skeleton of Salvinorin A." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1306524854.

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5

Casbohm, Jerry S. "Modifications to the Synthesis of the Salvinorin A Carbon Skeleton." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1462816273.

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6

Line, Nathan. "Total Synthesis of Salvinorin A via an IMDA-Tsuji Allylation Strategy." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1461161309.

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7

Yan, Feng. "Molecular mechanisms by which salvinorin A binds to and activates the k-opioid receptor." Cleveland, Ohio : Case Western Reserve University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1207342013.

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8

Kutrzeba, Lukasz. "Biosynthesis of Salvinorin A, : a potent hallucinogen from Salvia Divinorum Epling & Jativa /." Full text available from ProQuest UM Digital Dissertations, 2009. http://0-proquest.umi.com.umiss.lib.olemiss.edu/pqdweb?index=0&did=1804960241&SrchMode=1&sid=12&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1269370294&clientId=22256.

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9

Yan, Feng. "Molecular Mechanisms by which Salvinorin A Binds to and Activates the κ-Opioid Receptor". Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1207342013.

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10

McGee, Philippe. "Application of Gold(I) Catalysis in the Synthesis of Bridged Carbocycles, (±)-Magellanine and (±)-Salvinorin A." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/38485.

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Gold was considered for a long time to be an inert metal and was only in 1986 that the first homogeneous gold-catalyzed transformation was reported. In our laboratory, we isolated a surprisingly stable vinyl complex that resulted from an unexpected 1,2-silyl migration while working on a gold(I)-catalyzed reaction for the synthesis of polyprenylated polycyclic acylphloroglucinols (PPAPs). We herein report the isolation of a variety of organogold species where we could control the silyl migration based on the nature of the silyl group installed on the terminal alkyne. Silyl groups bearing an aro

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11

Zani, A. D. "Behavioural and EEG profile of two new recreational drugs : cocatropine and salvia divinorum (salvinorin A)." Doctoral thesis, Università degli Studi di Milano, 2009. http://hdl.handle.net/2434/63040.

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12

Lozama, Anthony. "Preparation of neoclerodane diterpenes as probes for the opioid receptor system." Diss., University of Iowa, 2010. https://ir.uiowa.edu/etd/703.

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While there are a variety of therapeutics that interact with the opioid receptor system, they are not without side effects; including constipation, dysphoria and respiratory depression. A better understanding of the opioid receptor system may yield therapeutic agents with a limited side effect profile. The neoclerodane diterpene, salvinorin A, appears to interact at opioid receptors through a unique mode of action. A better understanding of its interactions with opioid receptors will yield valuable information about the opioid system. In order to probe further how salvinorin A interacts at opi

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13

Mehl, Lea-Marina [Verfasser]. "Totalsynthese von Lingzhiol via radikalischer Cyclisierung sowie Studien zur Synthese der Kernstruktur von Salvinorin A / Lea-Marina Mehl." Tübingen : Universitätsbibliothek Tübingen, 2018. http://d-nb.info/1227771975/34.

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14

Holmberg, Pär. "Synthesis of Molecular Probes for Exploring the Human Consciousness, 5-HT7 Ligands and Salvinorins." Doctoral thesis, Uppsala universitet, Institutionen för läkemedelskemi, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4824.

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In this study, we have addressed the serotonergic and the opioid system within the CNS. Both systems are of outmost importance in the etiology of disease states, especially mental disorders. In our investigation of the serotonergic system, we have synthesized novel enantiomerically pure 6-aryl-3-amino- and 8-aryl-3-aminochromans as ligands for the 5-HT7 receptor. One reason for the lack of understanding of the physiological functionality of the serotonin 5-HT7 receptor, the most recently discovered member of the serotonin receptor family, is the absence of partial agonists and agonists. In th

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15

Singh, Nidhi. "Protein modeling in rational drug design ; case study with deoxyxylulose phosphate reductoisomerase enzyme : delineating a powerful virtual screening approach for GPCR's ; application to Salvinorin A, a selective Kappa opioid receptor agonist /." Full text available from ProQuest UM Digital Dissertations, 2007. http://0-proquest.umi.com.umiss.lib.olemiss.edu/pqdweb?index=0&did=1409502211&SrchMode=1&sid=4&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1220901252&clientId=22256.

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16

Holmberg, Pär. "Synthesis of Molecular Probes for Exploring the Human Consciousness, 5-HT₇ Ligands and Salvinorins." Doctoral thesis, Uppsala University, Department of Medicinal Chemistry, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4824.

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<p>In this study, we have addressed the serotonergic and the opioid system within the CNS. Both systems are of outmost importance in the etiology of disease states, especially mental disorders. </p><p>In our investigation of the serotonergic system, we have synthesized novel enantiomerically pure 6-aryl-3-amino- and 8-aryl-3-aminochromans as ligands for the 5-HT<sub>7</sub> receptor. One reason for the lack of understanding of the physiological functionality of the serotonin 5-HT<sub>7</sub> receptor, the most recently discovered member of the serotonin receptor family, is the absence of parti

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17

Lanfranchi, Don Antoine. "Vers la synthèse totale de la salvinorine A et d'analogues structuraux." Université Louis Pasteur (Strasbourg) (1971-2008), 2006. http://www.theses.fr/2006STR13239.

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18

Holmberg, Pär. "Synthesis of molecular probes for exploring the human consciousness, 5-HT₇ ligands and salvinorins /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4824.

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19

Maqueda, Sánchez Ana Elda. "Farmacología humana de la salvinorina A: estudio del mecanismo de acción central mediante bloqueo farmacológico de los efectos." Doctoral thesis, Universitat Autònoma de Barcelona, 2018. http://hdl.handle.net/10803/666961.

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Los datos disponibles en la actualidad indican que los efectos psicoactivos de la salvinorina A, el principio activo de la planta Salvia divinorum, se deberían al efecto agonista ejercido por este compuesto sobre el receptor kappa opioide. Sin embargo, hasta la fecha no se había atribuido a la neurotransmisión opioide ningún papel relevante en la regulación de la percepción. Las intensas modificaciones sensoriales referidas por los usuarios de la Salvia divinorum y las observadas en el laboratorio tras administración de salvinorina A se encuentran muy alejadas de las meras alteraciones

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20

Schiavo, Lucie. "Accès à de nouvelles plateformes chirales pour la synthèse d'analogues structuraux de la salvinorine A et de terpènes bioactifs." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAF025/document.

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La salvinorine A est un néoclérodane naturel possédant une forte affinité pour les récepteurs opioïdes kappa. Tout comme elle, de nombreux terpénoïdes bioactifs naturels, tels que l’acide hardwickiique, possèdent une chaîne latérale 2-(furan-3-yl)-éthyle en position 9. L’introduction de cette chaîne sur le squelette décaline est actuellement reportée dans la littérature en 3 à 8 étapes formelles et nécessitent souvent une dérivatisation préalable des autres fonctionnalités, diminuant ainsi la possibilité d’accéder à plusieurs analogues à partir d’un seul intermédiaire. L’objectif de ce travail

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21

Domingos, Sara Filipa Aquino. "Salvia divinorum e seus efeitos biológicos: “A critical review on the toxicity of Salvia divinorum and its major constituent Salvinorin A”." Master's thesis, 2015. http://hdl.handle.net/10400.6/6509.

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A presente dissertação está integrada na unidade curricular estágio do Mestrado Integrado em Ciências Farmacêuticas da Universidade da Beira Interior. Encontra-se dividida em dois capítulos, sendo que o primeiro corresponde à componente de investigação e o outro ao estágio curricular realizado na Farmácia Diamantino (Fundão). A Salvia divinorum (S. divinorum) é uma planta psicoativa original e tradicionalmente utilizada para fins medicinais e espirituais pelo povo Mazateca da região mexicana de Oaxaca. No entanto, de acordo com a Organização Mundial de Saúde (OMS), ao longo dos últimos anos t

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22

Pandit, Deepangi. "Ligand-based drug design I. conformational studies of GBR 12909 analogs as cocaine antagonists; II. 3d-QSAR studies of salvinorin a analogs as kappa opioid agonists /." Thesis, 2007. http://library1.njit.edu/etd/fromwebvoyage.cfm?id=njit-etd2007-051.

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23

Lin, Po-Xiang, and 林柏翔. "Quantitative Determination of Salvinorin A, a Natural Hallucinogen with Abuse Liability, in Salvia divinorum and Endemic Species of Salvia in Taiwan and Management of the Potential New Recreational Drug Use." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/51145101850381980454.

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碩士<br>高雄醫學大學<br>藥學研究所<br>100<br>Recently, use of recreational drugs has become a new trend among young drug users. Besides the well-known drugs such as marijuana, amphetamine, 3,4-methylenedioxymethamphetamine (MDMA) and ketamine, Salvia divinorum (Lamiaceae), which contains a hallucinogenic ingredient, salvinorin A, has been abused as a new phenomenon among young drug users. The mechanism of salvinorin A is a selective agonist at κ-opioid receptors and distinct from the classical hallucinogens. Hallucinatory effect of salvinorin A in Salvia divinorum is similar to marijuana, LSD and ketamine.

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24

Cruz, André Miguel Martins da. "Estudo in vitro dos efeitos de salvinorina A na expressão hepática de genes." Master's thesis, 2016. http://hdl.handle.net/10400.6/6303.

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As novas substâncias psicoativas (NPS) são, segundo a Observatório Europeu da Droga e da Toxicodependência (EMCDDA), todo e qualquer novo estupefaciente ou nova droga psicotrópica na sua forma pura, ou por preparar, que não é controlada pela Convenção Única das Nações Unidas de 1961 sobre os estupefacientes nem pela Convenção das Nações Unidas de 1971, mas que possa representar uma ameaça para a saúde pública comparativamente às substâncias listadas nessas convenções. Pelo seu crescente consumo a nível mundial e elevado desconhecimento do seus efeitos no organismo, as NPS têm-se tornado cada v

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