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Dissertations / Theses on the topic 'SAMDH1'

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Published: 18 May 2024

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1

Martin, Michaël. "Mécanisme moléculaire de l'antagonisme du complexe HUSH par les protéines lentivirales Vpx et Vpr." Electronic Thesis or Diss., Université Paris Cité, 2021. http://www.theses.fr/2021UNIP5160.

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Les VIH-1 et VIH-2, lentivirus responsables du SIDA, sont issus de transmissions inter-espèces de virus simiens (SIV) à l'homme. Outre leurs protéines de structure et de régulation, les lentivirus codent pour des protéines auxiliaires qui favorisent la réplication virale dans la cellule hôte en contrecarrant des facteurs cellulaires antiviraux, appelés facteurs de restriction. Le mécanisme d'action de ces protéines virales auxiliaires repose souvent sur le détournement de complexes Ubiquitine-Ligases, un mécanisme très répandu chez une grande variété de pathogènes, en vue de dégrader des proté
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Hani, Lylia. "Caractérisation et rôle des lymphocytes T CD4+ mémoires SAMHD1low au cours de l'infection par le VIH-1." Thesis, Paris Est, 2018. http://www.theses.fr/2018PESC0087/document.

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La mise en évidence du rôle de la molécule SAMHD1 dans l’infection par le VIH-1 en tant que facteur de restriction a ouvert de nouvelles perspectives dans la compréhension de la pathogénicité du virus.En effet, il a été clairement démontré que dans les cellules myéloïdes comme les monocytes/macrophages et les cellules dendritiques ainsi que les lymphocytes T CD4+ quiescents, SAMHD1 jouait un rôle important dans la protection de ces cellules de l’infection. En revanche, le rôle de cette molécule dans l’infection des lymphocytes activés, qui sont souvent la cible préférentielle du virus, n’est p
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Valverde, Estrella Lorena. "TREX1 and SAMHD1, and Aicardi-Goutières Syndrome." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/291940.

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Aicardi-Goutières Syndrome (AGS) is a rare encephalopathy which mimics a viral intrauterine infection and is characterized by calcifications of the basal ganglia, cerebral atrophy and IFN-a in the cerebrospinal fluid. AGS is a heterogenic disease associated with mutations in the gene of the exonuclease TREX1, in any of the genes codifying for the ribonuclease H2, in the phosphohydrolase SAMHD1, in the deaminase ADAR1 or in the cytoplasmic sensor MDA5. The knowledge of these functions is basic for the comprehension of the beginning of the pathogenesis of AGS. In this thesis we focused in the me
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Antonucci, Jenna Marie. "Mechanisms of HIV-1 Restriction by the Host Protein SAMHD1." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1524006072232491.

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Sébert, Marie. "Génétique et évolution clonale des syndromes d’insuffisance médullaire." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCC271.

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Les syndromes d’insuffisance médullaire sont liés à des mutations constitutionnelles à l’origine d’une hématopoïèse déficiente chez les patients atteints. Ils représentent un groupe hétérogène de maladies syndromiques, et impliquent plusieurs familles de gènes avec des mécanismes biologiques différents conduisant à l’insuffisance médullaire. Ces maladies prédisposent à une évolution clonale somatique, avec un risque accru de développer un syndrome myélodysplasique (SMD) ou une leucémie aigüe myéloïde (LAM) au cours du temps. Nous avons séquencé et analysé l’exome d’ADN fibroblastique d’une coh
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Louis, Tania. "Étude des fonctions cellulaires de SAMHD1, facteur de restriction du VIH-1." Thesis, Montpellier, 2015. http://www.theses.fr/2015MONTS050/document.

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L'étude des interactions entre un pathogène et son hôte, bien qu'ayant généralement pour objectif de contrôler l'infection par le pathogène, permet parfois de découvrir des éléments fondamentaux sur le fonctionnement de l'hôte. J'ai choisi d'étudier les fonctions cellulaires d'une protéine initialement identifiée comme un facteur de restriction du VIH-1. SAMHD1 (SAM domain and HD domain-containing protein 1) est une protéine exprimée dans la plupart des tissus humains. Elle est capable d'hydrolyser les déoxyribonucléotides triphosphates (dNTP) cellulaires et possède une activité nucléase cibla
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Silva, Maria-João. "Role of CTF18 and SAMHD1 in human DNA replication and genome integrity maintenance." Thesis, Montpellier 2, 2014. http://www.theses.fr/2014MON20236.

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La phase S est une période critique du cycle cellulaire au cours de laquelle le génome est particulièrement vulnérable. La duplication efficace des génomes eucaryotes dépend de la progression de milliers de fourches de réplication. Les premières étapes de la tumorigenèse sont associées au stress de réplication spontané, caractérisé par un blocage de la fourche. Comprendre comment le stress de réplication survient dans les cellules normales et contribue à la tumorigenèse est un grand défi dans la recherche sur le cancer. Mon travail de thèse vise à comprendre la régulation de la progression de
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Qin, Zhihua. "SAMHD1 Negatively Regulates the Innate Immune Responses to Inflammatory Stimuli and Viral Infection." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1587587968104986.

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Cenker, Jennifer Jean. "DIFFERENTIAL HIV-1 SUSCEPTIBILITY OF PRIMARY MACROPHAGE POPULATIONS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1491656059069304.

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Wang, Feifei. "Comparison of Murine and Human SAMHD1’s Role in Retroviral Restriction and Cell Cycle Progression." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1448450028.

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Coquel, Flavie. "Etude du rôle de SAMHD1 dans la réponse au stress réplicatif et la production d’interférons de type I." Thesis, Montpellier, 2018. http://www.theses.fr/2018MONTT043/document.

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La réplication de l’ADN est un processus extrêmement complexe, impliquant des milliers de fourches de réplication progressant le long des chromosomes. Ces fourches sont fréquemment ralenties ou arrêtées par différents obstacles, tels que des structures secondaires de l’ADN, des protéines agissant sur la chromatine ou encore un manque de nucléotides. Ce ralentissement, qualifié de stress réplicatif, joue un rôle central dans le développement tumoral. Des processus complexes, qui ne sont pas encore totalement connus, sont mis en place pour répondre à ce stress. Certaines nucléases, comme MRE11 e
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Samih, Younes [Verfasser]. "Dialectal Arabic processing Using Deep Learning / Younes Samih." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2018. http://d-nb.info/115091856X/34.

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Deutschmann, Janina [Verfasser], Thomas [Akademischer Betreuer] Gramberg, and Robert [Gutachter] Slany. "Regulatory Mechanism of the Innate Restriction Factor SAMHD1 in Herpesviral Infections / Janina Deutschmann ; Gutachter: Robert Slany ; Betreuer: Thomas Gramberg." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2020. http://d-nb.info/1221370456/34.

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Thientosapol, Sanchai. "Mechanisms of transversion mutation are dependent on sequence context and nucleotide paucity during antibody somatic hypermutation." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/20061.

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Somatic hypermutation of antibodies during humoral immune responses depends on expression of Activation Induced Deaminase (AID) in antibody-producing B cells. AID initiates somatic hypermutation by converting cytosine (C) residues in antibody genes into uracil (U) residues, by deamination. Alone, conversion of cytosine into uracil can only produce C:G to T:A transition mutations, by replication across U (phase 1A mutation). Processing of C deaminations by base excision repair (BER) or mismatch repair (MMR) diversifies mutation, predominantly at C:G (phase 1B mutation) and A:T (phase 2 mutation
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Abe, Junya. "A nationwide survey of Aicardi-Goutieres syndrome patients identifies a strong association between dominant TREX1 mutations and chilblain lesions: Japanese cohort study." Kyoto University, 2014. http://hdl.handle.net/2433/188647.

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Hallaq, Sameh [Verfasser]. "Human Capital in Palestine: Causes and Consequences / Sameh Hallaq." Wuppertal : Universitätsbibliothek Wuppertal, 2019. http://d-nb.info/1196132283/34.

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Jaffer, Ali Mohammed Hakim. "Multifaceted roles of the transmembrane nuclear envelope protein, Samp1." Doctoral thesis, Stockholms universitet, Institutionen för neurokemi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-141816.

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The eukaryotic nuclear envelope (NE), separates the nucleoplasm from cytoplasm and is made up of two concentric lipid membranes, the outer and the inner nuclear membranes (ONM and INM), the nuclear pore complexes (NPCs) and an underlying filamentous nuclear lamina. The INM contains hundreds of unique transmembrane proteins of which only a handful have been characterized. In this thesis, I aimed to understand the functional organization of proteins in the nuclear envelope and I focused on investigating the functions of a recently identified INM transmembrane protein, Samp1. We have developed a
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Herrmann, Alexandra [Verfasser], Thomas [Akademischer Betreuer] Gramberg, and Lars [Gutachter] Nitschke. "The role of SAMHD1 in restriction and immune sensing of retroviruses and retroelements / Alexandra Herrmann ; Gutachter: Lars Nitschke ; Betreuer: Thomas Gramberg." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2018. http://d-nb.info/1164768514/34.

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Martinat, Charlotte. "Rôle de la sumoylation dans les activités de SAMHD1, un facteur de restriction du VIH-1 dans les cellules non cyclantes." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCC246.

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Depuis sa découverte il y a sept ans, les recherches intensives sur SAMHD1 en ont fait un facteur cellulaire important qui limite la réplication du virus de l’immunodéficience humaine de type 1 (VIH-1) à l’étape de transcription inverse dans les cellules immunitaires non-cyclantes. Le VIH-2 et certains virus de l’immunodéficience simienne (VIS) surmontent cette restriction en exprimant la protéine Vpx, qui conduit SAMHD1 à sa dégradation protéasomique. De nombreuses données expérimentales indiquent que l’activité triphosphohydrolase (dNTPase) de SAMHD1, qui diminue les niveaux cellulaires de d
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COGHI, MARIA DONATA. "Samdi mass spectrometry for high yield protein modification reaction development." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2014. http://hdl.handle.net/10281/50887.

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Efficient chemical strategies that attach synthetic molecules to desired positions on protein surfaces are useful tools in the field of chemical biology and represent one major prerequisite for the development of new drugs and materials. Protein modification with polyethylene glycol (PEG) groups is indeed routinely performed on therapeutic proteins to improve serum half-life, or even cytotoxins or imaging agents are efficiently conjugated to cancer-targeting elements. In a typical approach, a synthetic functional group of interest is attached to a uniquely reactive amino acid group introduced
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Wichit, Sineewanlaya. "Rôle du cholestérol, de la protéine SAMHD1 et de la salive d’Aedes aegypti dans l’infection des cellules cutanées par le virus Chikungunya." Thesis, Montpellier, 2017. http://www.theses.fr/2017MONTT037.

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Le virus Chikungunya (CHIKV), arbovirus en pleine ré-émergence, a envahi rapidement de nombreuses zones géographiques du monde. La propagation mondiale de ce virus constitue une menace pour la santé humaine car il n'y a pas de vaccin ou d'agents antiviraux appropriés pour contrôler l'infection virale. La transmission du virus s’effectue lors de la piqure d’un moustique infecté du genre Aedes, qui injecte sa salive contenant le virus dans la peau de l’hôte humain. Afin de contrôler la dissémination du virus, il est primordial de développer des recherches sur l’identification de molécules antivi
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Wallentin, Jan. "Vägar till samadhi : En granskning av Robert K. C. Formans begrepp Pure Consciousness Event." Thesis, Umeå universitet, Institutionen för idé- och samhällsstudier, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-184305.

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Jan Wallentin. Vägar till samadhi : en granskning av Robert K. C. Formans begrepp ”Pure Consciousness Event” (Roads to Samadhi : An Examination of Robert K. C. Forman’s Concept of ”Pure Consciousness Event”). Umeå University: Department of Historical, Philosophical and Religious studies. Bachelor thesis. June 2021.Is Robert K. C. Forman’s concept of ”pure consciousness event” an example of a universal,mystical core experience? Is it possible to establish the neural correlates of this proposedexperience, and to induce it experimentally? These are the main questions of this study,which is a lite
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Güthlein, Nora [Verfasser], and Alexander [Akademischer Betreuer] Rapp. "Geburtensaisonalität psychischer Störungen - Zum Effekt von meteorologischen Variablen / Nora Samiha Güthlein ; Betreuer: Alexander Rapp." Tübingen : Universitätsbibliothek Tübingen, 2017. http://d-nb.info/1199545929/34.

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Anabousi, Samah [Verfasser]. "Liposomal Drug Carrier Systems for Inhalation Treatment of Lung Cancer / Samah Anabousi." Aachen : Shaker, 2006. http://d-nb.info/1186583851/34.

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Argüelles, Camilla. "Étude du rôle de la protéine de liaison aux ARN messagers Smaug dans la voie Hedgehog chez la drosophile." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC053.

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Les protéines signal Hedgehog (HH) sont des acteurs majeurs du développement animal et de la carcinogenèse. Leur transduction requiert la protéine à 7 domaines transmembranaires Smoothened (SMO) dont l’activité est régulée par Patched (PTC), un récepteur et antagoniste d’HH. PTC et HH régulent le trafic, la phosphorylation et l’accumulation de SMO mais de nombreux aspects de sa régulation restent incompris. Au cours de ma thèse, j’ai travaillé sur Smaug, un nouveau partenaire de SMO chez la drosophile identifié au laboratoire dans un crible double-hybride. Smaug est connue pour lier et réprime
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Miazzi, Cristina. "The role of deoxynucleotide trafficking and degradation in the maintenance of balanced pools of DNA precursors in mammalian cells." Doctoral thesis, Università degli studi di Padova, 2014. http://hdl.handle.net/11577/3423656.

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Deoxynucleoside triphosphates (dNTPs) are the precursors for DNA synthesis. Their balanced concentrations ensure the accuracy of nuclear and mitochondrial DNA replication and of DNA repair. dNTP pool sizes and relative proportions are regulated by a network of anabolic and catabolic enzymes, operating in the cytosol and in mitochondria. Cytosolic and mitochondrial pools are separated by the impermeable inner mitochondrial membrane but multiple evidences suggest the existence of mitochondrial carriers mediating the transport of deoxynucleotides between the two compartments. PNC1 has been identi
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Leães, Roberta Nascimento. "Desenvolvimento de um sistema para avaliação de marcha em simulação de hipogravidade (SAMSH)." Pontifícia Universidade Católica do Rio Grande do Sul, 2006. http://hdl.handle.net/10923/3213.

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Made available in DSpace on 2013-08-07T18:53:36Z (GMT). No. of bitstreams: 1 000381334-Texto+Completo-0.pdf: 6367136 bytes, checksum: 716f74010bd32220b99263adadc163cd (MD5) Previous issue date: 2006<br>This study aimed to develop a Walking Pattern Evaluation System during Hypogravity Simulation (SAMSH), which included the adaptation of a body suspension device, the instrumentation of a treadmill and the development of a virtual environment. The system was tested using only one subject because this research did not have the objective of validating SAMSH. Cinematic analyses were performed whil
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Kutzner, Juliane [Verfasser], and Martin [Akademischer Betreuer] Müller. "Dissecting SAMHD1´s role in the type I Interferon induced early block to HIV-1 infection and its connection to cancer / Juliane Kutzner ; Betreuer: Martin Müller." Heidelberg : Universitätsbibliothek Heidelberg, 2019. http://d-nb.info/1197904344/34.

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Marc, Corral Juan. "Molecular genetics of autosomal dominant ataxias: identification and characterisation of two novel spinocerebellar ataxia subtypes." Doctoral thesis, Universitat Autònoma de Barcelona, 2021. http://hdl.handle.net/10803/672062.

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Les atàxies espinocerebel·loses (SCAs) consisteixen en un grup heterogeni de trastorns del moviment hereditaris caracteritzats clínicament per atàxia progressiva associada de forma variable amb altres signes neurològics addicionals com són signes piramidals o extrapiramidals, oftalmoplegia, retinosi pigmentària, demència o convulsions. Aquesta heterogeneïtat clínica s’explica per l’heterogeneïtat genètica, amb més de 53 loci i 40 gens identificats i associats fins a dia d’avui. En aquesta tesi s’ha estudiat una cohort de 308 pacients amb atàxia, identificant variants genètiques causatives en 8
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Samaha, Mahboub Caline. "Logique et Réalité chez Hegel et Aristote. Dialogue avec Adorno et Deleuze." Electronic Thesis or Diss., Poitiers, 2019. http://theses.univ-poitiers.fr/66692/2019-Samaha-Mahboub-Caline-These.

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Dans cette thèse, nous remettons en question la critique faite à l'identité comme étant ce qui opprime la différence et l'évolution. Nous essayons de montrer que la recherche de l'identité propre au système hégélien ne porte pas atteinte au réel mais au contraire l'enrichit et est une condition pour son évolution et pour notre liberté. Nous montrons aussi comment l'accent mis sur l'unité lors de l'interprétation d'un philosophe, ici Aristote, est légitime parce qu'il nous permet de souligner chez lui une contribution à la recherche de la connaissance et de la liberté bien plus que ne le ferait
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Sameh, Abdel Hadi Ali [Verfasser]. "Die Chelatbildung der dreiwertigen Transplutoniumelemente mit Nitrilotriessigsäure und ihren Derivaten / Abdel Hadi Ali Sameh." Karlsruhe : KIT-Bibliothek, 2008. http://d-nb.info/1186086491/34.

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Pham, Thu Hang. "Molecular biology and biochemistry of the polyamine pathway in rice : the role of SAMDC." Thesis, University of Newcastle Upon Tyne, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275414.

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Dridi, Sameh [Verfasser], Peter [Gutachter] Heine, and Thomas [Gutachter] Zitelmann. "Die Bedeutung der spirituellen Heilung in Tunesien / Sameh Dridi ; Gutachter: Peter Heine, Thomas Zitelmann." Berlin : Humboldt-Universität zu Berlin, 2012. http://d-nb.info/1208079840/34.

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Kung, Jason. "Effects of ionizing radiation on osseous healing in SAMR1 and SAMP6 mice: a histiological study." Thesis, Boston University, 2012. https://hdl.handle.net/2144/12460.

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Thesis (M.A.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Previous studies have showed effects of irradiation on bone and on fracture healing. This is a histological study of the effect of a combined irradiation/fracture injury model in a strain of aged mice (SAMP6) an
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Le?es, Roberta Nascimento. "Desenvolvimento de um sistema para avalia??o de marcha em simula??o de hipogravidade (SAMSH)." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2006. http://tede2.pucrs.br/tede2/handle/tede/2995.

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Made available in DSpace on 2015-04-14T13:56:11Z (GMT). No. of bitstreams: 1 381334.pdf: 6367136 bytes, checksum: 716f74010bd32220b99263adadc163cd (MD5) Previous issue date: 2006-03-31<br>Este estudo ? referente ao desenvolvimento de um Sistema de Avalia??o de Marcha em Simula??o de Hipogravidade (SAMSH). Para tal, fez-se necess?rio o aprimoramento de um Sistema de Suspens?o Corporal (SSC) e instrumenta??o de uma esteira el?trica para a constru??o de uma plataforma de movimento como uma t?cnica de locomo??o f?sica em um ambiente virtual. O SAMSH foi testado em um ?nico indiv?duo, pois este e
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Al-Areqi, Samih Taha Mohammed [Verfasser], and Tiziana [Akademischer Betreuer] Margaria-Steffen. "Semantics-based automatic geospatial service composition / Samih Taha Mohammed Al-Areqi ; Betreuer: Tiziana Margaria-Steffen." Potsdam : Universität Potsdam, 2017. http://d-nb.info/1218402814/34.

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Al-shehabi, Hussein [Verfasser]. "The role of human SAMHD1 in restricting porcine endogenous retroviruses (PERVs) and the innate immune response to PERV infection in human primary immune cells / Hussein Ali Nasser Al-shehabi." Berlin : Freie Universität Berlin, 2020. http://d-nb.info/1215099088/34.

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Al-shehabi, Hussein Ali Nasser [Verfasser]. "The role of human SAMHD1 in restricting porcine endogenous retroviruses (PERVs) and the innate immune response to PERV infection in human primary immune cells / Hussein Ali Nasser Al-shehabi." Berlin : Freie Universität Berlin, 2020. http://d-nb.info/1215099088/34.

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Pereira, Gonçalo Filipe de Almeida. "Estudo de regiões de susceptibilidade para o cancro do cólon e recto familiar do tipo x: análise de genes candidatos e de ganhos/deleções em tumores." Master's thesis, Escola Superior de Saúde Egas Moniz, 2014. http://hdl.handle.net/10400.26/7853.

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Dissertação para obtenção do grau de Mestre em Biologia Molecular em Saúde<br>O cancro do cólon e recto familiar do tipo X (FCCTX) define as famílias que preenchem os critérios de Amesterdão, mas nas quais não é identificada mutação germinal nos genes de reparação de erros de DNA do tipo mismatch (MMR) e cujos tumores não apresentam instabilidade de microsatélites. A sua causa molecular não é ainda conhecida. O presente trabalho teve como objectivo avaliar o envolvimento de genes localizados em duas regiões de susceptibilidade previamente identificadas (13q32-33 e 21q11) e o esclarecimento das
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Pattni, Ramesh. "A psychological understanding of the Yogasūtra of Patañjali (sūtra 1 to 6) with a comparative phenomenology of Samādhi and flow." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:a8e852cf-2efa-4821-b77b-ae3db1b34083.

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Over the past thirty years, academic dialogue on the relationships between science and religion within historical, theological and philosophical contexts has flourished, with the importance of this dialogue being positively expressed. In particular, at the intersection of psychology and religion there is a triple relationship between these domains and in this thesis, we bring the Hindu tradition of Classical Yoga into this discourse, aiming for a psychological understanding of the Yogasutra of Patañjali as the primary text of this tradition. With a 'psychology in religion' perspective we ident
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Motumi, N. E. "The implementation of the affirmative action policy in the South African Military Health Service (SAMHS) 1995 - 2000." Diss., Pretoria : [s.n.], 2006. http://upetd.up.ac.za/thesis/available/etd-08282007-150015.

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Radebe, Chrystal. "The mentoring of officers commanding in the SA Military Health Service (SAMHS): a military social work perspective." Thesis, Stellenbosch : University of Stellenbosch, 2009. http://hdl.handle.net/10019.1/2878.

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Thesis (M Social Work (Social Work))--University of Stellenbosch, 2009.<br>An exploratory research design together with a quantitative research approach were chosen to determine whether military social workers possess the necessary knowledge, skills and values to mentor Officers Commanding (OCs) in the South African Military Health Service (SAMHS). The motivation for this study was based on questions the researcher asked as to whether there was a link between the methods in social work intervention processes, supervision and mentoring processes. During the preliminary investigation, the
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Hlawatsch, Julia [Verfasser], and Thomas [Akademischer Betreuer] Langmann. "Sterile alpha motif containing 7 (Samd7) is a novel Crx-regulated transcriptional repressor in the retina / Julia Hlawatsch. Betreuer: Thomas Langmann." Regensburg : Universitätsbibliothek Regensburg, 2013. http://d-nb.info/1044754176/34.

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Al-Muqdadi, Sameh Wisam [Verfasser], Broder [Akademischer Betreuer] Merkel, Broder [Gutachter] Merkel, Peter [Gutachter] Udluft, and Volkmar [Gutachter] Dunger. "Groundwater investigation and modeling - western desert of Iraq / Sameh Wisam Al-Muqdadi ; Gutachter: Broder Merkel, Peter Udluft, Volkmar Dunger ; Betreuer: Broder Merkel." Freiberg : Technische Universitaet Bergakademie Freiberg Universitaetsbibliothek "Georgius Agricola", 2012. http://d-nb.info/1220837040/34.

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45

Vijayaraghavan, Balaje. "Identification and characterization of protein-protein interactions in the nuclear envelope." Doctoral thesis, Stockholms universitet, Institutionen för neurokemi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-148432.

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The nuclear envelope forms the interface between the nucleus and the cytoplasm. The nuclear envelope consists of the two concentric lipid membranes, the nuclear pores and the nuclear lamina. The inner nuclear membrane contains hundreds of unique transmembrane proteins showing high tissue diversity. Mutations of some proteins in the nuclear envelope give rise to a broad spectrum of diseases called envelopathies or laminopathies. In this thesis, I aimed to study the functional organization of the nuclear envelope by identifying and characterizing interactions between the nuclear envelope protein
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46

Madiba, Thomas Khomotjo. "Evaluation of dental emergency outcomes of the Oral Health Fitness Classification of the South African Military Health Service (SAMHS) in Gauteng - South Africa." Diss., University of Pretoria, 2012. http://hdl.handle.net/2263/30881.

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Background: The South African National Defence Force (SANDF) like other Defence Forces of the world, conducts medical classification on their members. This medical classification has, as one of the components, an Oral Health Fitness (OHF) classification which is done according to North Atlantic Treaty Organisation (NATO) standards. The aim of the Oral Health Fitness classification is to standardize dental readiness, assess oral health, prioritize dental care, minimize the number of dental emergencies (DE), and emphasize the importance of good oral health to all active duty and reserve forces.
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47

Nishimura, Yasumitsu. "Insufficient IL-2 production from splenic CD4[+] T cells causes impaired cell proliferation and early apoptosis in SAMP1, a strain of senescence-accelerated mouse." Kyoto University, 2002. http://hdl.handle.net/2433/149355.

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Dridi, Sameh [Verfasser], Peter [Akademischer Betreuer] Heine, and Thomas [Akademischer Betreuer] Zitelmann. "Die Bedeutung der spirituellen Heilung in Tunesien : eine aktuelle Untersuchung zur Stellung der tibb rûhânî für die Jugendlichen / Sameh Dridi. Gutachter: Peter Heine ; Thomas Zitelmann." Berlin : Humboldt Universität zu Berlin, Philosophische Fakultät III, 2012. http://d-nb.info/1020663421/34.

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Aparicio, Siegmund Samadhi [Verfasser], Jürgen [Akademischer Betreuer] Scheller, and Lutz [Akademischer Betreuer] Schmitt. "Rezeptor cross-talk und die Rolle der Protein Kinase CK2 in der Signaltransduktion von Zytokinen der Interleukin (IL)-6/IL-12-Familie / Samadhi Aparicio Siegmund. Gutachter: Jürgen Scheller ; Lutz Schmitt." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2015. http://d-nb.info/1067229175/34.

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Del, Valle i. Macià Jaume. "Estudi de la relació existent entre les alteracions de la barrera hematoencefàlica i la beta-amiloïdosi en el model murí de senescència accelerada i malaltia d'Alzheimer SAMP8." Doctoral thesis, Universitat de Barcelona, 2010. http://hdl.handle.net/10803/1838.

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La malaltia d'Alzheimer (MA) es caracteritza per la presència a l'hipocamp i l'escorça de plaques senils de la proteïna &#946;-amilode (A&#946;), cabdells neurofibrilars de la proteïna tau hiperfosforilada i pèrdua de sinapsis. La hipòtesi neurovascular de la MA dóna una especial importància a les alteracions de la Barrera Hematoencefàlica (BHE) i els increments de la proteïna &#946;-amilode (A&#946;). Els ratolins modificats genèticament són els models animals més utilitzats en la investigació de la MA. Tanmateix, aquests ratolins imiten aspectes de la MA de tipus familiar, on alteracions gen
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