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Journal articles on the topic 'San Martino (Hospital : Genoa, Italy)'

Author: Grafiati

Published: 28 July 2024

Last updated: 31 July 2025

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1

Durando, Paolo, Cristiano Alicino, Andrea Orsi, et al. "Latent Tuberculosis Infection among a Large Cohort of Medical Students at a Teaching Hospital in Italy." BioMed Research International 2015 (2015): 1–6. http://dx.doi.org/10.1155/2015/746895.

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The surveillance of latent tuberculosis infection (LTBI) in both healthcare workers and healthcare students is considered fundamental for tuberculosis (TB) prevention. The aim of the present study was to estimate LTBI prevalence and evaluate potential risk-factors associated with this condition in a large cohort of medical students in Italy. In a cross-sectional study, performed between March and December 2012, 1511 eligible subjects attending the Medical School of the University of Genoa, trained at the IRCCS San Martino-IST Teaching Hospital of Genoa, were actively called to undergo the tube

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Malaguti, Maria Chiara, Lorenzo Gios, Bruno Giometto, et al. "Artificial intelligence of imaging and clinical neurological data for predictive, preventive and personalized (P3) medicine for Parkinson Disease: The NeuroArtP3 protocol for a multi-center research study." PLOS ONE 19, no. 3 (2024): e0300127. http://dx.doi.org/10.1371/journal.pone.0300127.

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Background The burden of Parkinson Disease (PD) represents a key public health issue and it is essential to develop innovative and cost-effective approaches to promote sustainable diagnostic and therapeutic interventions. In this perspective the adoption of a P3 (predictive, preventive and personalized) medicine approach seems to be pivotal. The NeuroArtP3 (NET-2018-12366666) is a four-year multi-site project co-funded by the Italian Ministry of Health, bringing together clinical and computational centers operating in the field of neurology, including PD. Objective The core objectives of the p

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Di Pilato, Vincenzo, Giulia Codda, Lorenzo Ball, et al. "Molecular Epidemiological Investigation of a Nosocomial Cluster of C. auris: Evidence of Recent Emergence in Italy and Ease of Transmission during the COVID-19 Pandemic." Journal of Fungi 7, no. 2 (2021): 140. http://dx.doi.org/10.3390/jof7020140.

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Candida auris is an emerging MDR pathogen raising major concerns worldwide. In Italy, it was first and only identified in July 2019 in our hospital (San Martino Hospital, Genoa), where infection or colonization cases have been increasingly recognized during the following months. To gain insights into the introduction, transmission dynamics, and resistance traits of this fungal pathogen, consecutive C. auris isolates collected from July 2019 to May 2020 (n = 10) were subjected to whole-genome sequencing (WGS) and antifungal susceptibility testing (AST); patients’ clinical and trace data were al

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Rahmani, Alborz, Guglielmo Dini, Andrea Orsi, et al. "Reactogenicity of BNT162b2 mRNA COVID-19 Vaccine in a Young Working Age Population: A Survey among Medical School Residents, within a Mass Vaccination Campaign, in a Regional Reference Teaching Hospital in Italy." Vaccines 9, no. 11 (2021): 1269. http://dx.doi.org/10.3390/vaccines9111269.

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Vaccinations are a key prevention measure in fighting the COVID-19 pandemic. The BNT162b2 mRNA vaccine (BioNTech/Pfizer), the first to receive authorization, was widely used in the mass vaccination campaign in Italy. Healthcare workers were identified as a priority group for vaccination, but few studies have assessed its reactogenicity among the young working age population. An online survey was conducted to investigate the adverse reactions occurring in the 7 days following the first and second vaccination doses amongst resident doctors of the University of Genoa, employed at the IRCCS Ospeda

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Piatti, Gabriella, Marco Bruzzone, Vincenzo Fontana, Alessandro Mannini, and Marcello Ceppi. "Epidemiology of Clostridium Difficile Infection in a Large Hospital in Northern Italy: Questioning the Ward-Based Transmission." Open Microbiology Journal 11, no. 1 (2017): 360–71. http://dx.doi.org/10.2174/1874285801711010360.

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Background:Clostridium Difficileinfection (CDI) is considered a ward-based nosocomial infection, due to contagion among patients. Molecular studies recently questioned ward-based contact for disease spread.Objective:To investigate whether it is plausible that CDI spread in San Martino Hospital of Genoa was due to a ward-based contact and patient-to-patient diffusion.Methods:We conducted a retrospective cohort study of CDI cases from April 2010 to March 2015. We referred to Hospital data set and Admission Service. Multilevel modelling approach and ecological analysis were used to assessC. diffi

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Izzotti, A., E. Grasselli, M. Barbaresi, et al. "Development of an integrated environmental monitoring protocol for SARS-CoV-2 contamination. Applications at the IRCSS San Martino Polyclinic Hospital in Genoa, Italy." Environmental Research 209 (June 2022): 112790. http://dx.doi.org/10.1016/j.envres.2022.112790.

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Magnasco, Laura, Malgorzata Mikulska, Daniele Roberto Giacobbe, et al. "Spread of Carbapenem-Resistant Gram-Negatives and Candida auris during the COVID-19 Pandemic in Critically Ill Patients: One Step Back in Antimicrobial Stewardship?" Microorganisms 9, no. 1 (2021): 95. http://dx.doi.org/10.3390/microorganisms9010095.

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The possible negative impact of severe adult respiratory distress caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection (COVID-19) on antimicrobial stewardship and infection control has been postulated, but few real-life data are available. The aim of this study was to report our experience with colonization/infection of carbapenem-resistant Pseudomonas aeruginosa (CRPA), carbapenem-resistant Klebsiella pneumoniae (CR-Kp) and Candida auris among critically ill COVID-19 patients admitted to the intensive care unit (ICU). All COVID-19 patients admitted to the ICUs at S

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De Pace, Vanessa, Bianca Bruzzone, Valentina Ricucci, et al. "Molecular Diagnosis of Human Monkeypox Virus during 2022–23 Outbreak: Preliminary Evaluation of Novel Real-Time Qualitative PCR Assays." Microorganisms 12, no. 4 (2024): 664. http://dx.doi.org/10.3390/microorganisms12040664.

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In 2022–23, the human monkeypox virus (MPXV) caused a global outbreak in several non-endemic countries. Here, we evaluated the diagnostic performance of four real-time qualitative PCR assays for the laboratory diagnosis of mpox (monkeypox) monkeypox disease. From July to August 2022, 27 positive and 10 negative specimens (lesion, crust and exudate swabs) were tested in the laboratory of the Hygiene Unit of the San Martino Hospital (Genoa, Italy) by using home-made real-time PCR to detect MPXV generic G2R_G DNA. According to the manufacturer’s instructions, we also retrospectively analyzed thes

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Atzori, Giulia, Simonetta Franchelli, Marco Gipponi, et al. "Inferior Pedicle Reduction Mammoplasty as Corrective Surgery after Breast Conserving Surgery and Radiation Therapy." Journal of Personalized Medicine 12, no. 10 (2022): 1569. http://dx.doi.org/10.3390/jpm12101569.

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Background/Aim—Twenty patients had corrective reconstruction surgery by means of a reduction mammaplasty or mastopexy after a previous BCS (Breast Conserving Surgery) and RT (Radiation Therapy); the risk factors and post-operative complications were reported in order to define a safe and effective technique for reduction mammaplasty in previously irradiated breast cancer patients. Materials and Methods—From June 2011 to December 2019, 20 pts. were operated on at the Breast Surgery Clinic of San Martino Policlinic Hospital, Genoa, Italy. Pre- and post-operative parameters included clinic-pathol

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Muzyka, Mariya, Silvia Ottaviani, Irene Caffa, et al. "Prognostic Frailty-Based Determinants of Long-Term Mortality in Older Patients with Newly Diagnosed Multiple Myeloma." Cancers 17, no. 5 (2025): 789. https://doi.org/10.3390/cancers17050789.

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Background/Objectives: Multiple myeloma (MM) is a plasma cell neoplasm predominantly diagnosed in older adults. However, the significance of defining patient frailty, as well as identifying the most suitable and reliable tools for its assessment, remains to be firmly established. Methods: This retrospective observational study investigated 36 patients aged 65 or older who underwent Comprehensive Geriatric Assessment (CGA). The average patient age was 76 (SD 6.22), with 33.3% being female. Patients were evaluated using the International Myeloma Working Group Frailty Index (IMWG-FI) and the 40-i

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Tukenmez Tigen, Elif, Malgorzata Mikulska, Buket Erturk Sengel, et al. "Efficacy of favipiravir in COVID-19: A retrospective two center comparative study." Journal of Infection in Developing Countries 18, no. 09 (2024): 1313–19. http://dx.doi.org/10.3855/jidc.18039.

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Introduction: Favipiravir (FVP) is an antiviral, targeting RNA-dependent RNA polymerase. We aimed to evaluate the efficacy of FVP as a treatment for COVID-19. Methods: We conducted a retrospective study in two centers (San Martino University Hospital in Genova, Italy, and Marmara University Pendik Training and Research Hospital, Turkey). Adult patients (inpatients) diagnosed with COVID-19 between March and June 2020 were included. All patients in the Italian center received the standard of care (SoC) treatment, while in the Turkish center patients received FVP in addition to SoC. Results: Six

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Varesano, Serena, Giulia Ciccarese, Michele Paudice, et al. "Evaluating HPV Viral Load and Multiple Infections for Enhanced Cervical Cancer Risk-Based Assessment." Life 15, no. 2 (2025): 153. https://doi.org/10.3390/life15020153.

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Human papillomavirus (HPV) is a major cause of cervical cancer, a significant health concern worldwide. Despite advances in screening methods, including the Pap test and the HPV DNA test, limitations remain in accurately predicting which HPV infections will progress to cervical intraepithelial neoplasia (CIN) and, eventually, invasive cancer. This study evaluates the usefulness in real life of assessing HPV viral load and the presence of multiple HPV genotypes in enhancing the diagnostic accuracy of triage in cervical cancer screening. A retrospective analysis was performed on 55 formalin-fixe

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Romano, Paolo DM. "Bioinformatics activities at the University Hospital San Martino IST in Genoa." EMBnet.journal 23 (April 28, 2017): 884. http://dx.doi.org/10.14806/ej.23.0.884.

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Giorgetti, Giulia, Pamela Becherini, Elena Maroto-Martin, et al. "Higher CD56 Expression on Multiple Myeloma Cells Increases CD38 Expression, Reduces Intracellular NAD+ Levels, and Enhances the Efficacy of Daratumumab-Based Treatment Strategies." Blood 142, Supplement 1 (2023): 1951. http://dx.doi.org/10.1182/blood-2023-189439.

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NCAM1 (Neural Cell Adhesion Molecule 1), also known as CD56, is a member of the immunoglobulin superfamily and is deregulated in many tumors. In multiple myeloma (MM), high levels of CD56 are observed on MM cells in 70% of patients. This molecule has several functions including tumor growth, adhesion and response to therapy, as suggested by several studies. However, an extensive analysis of the specific landscape underlying its presence and its role as a prognostic biomarker is lacking, especially in MM. Here, we evaluated CD56 surface levels on tumor cells collected from 136 newly diagnosed M

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Magnani, Luca, Luca Carmisciano, Felice dell’Orletta, et al. "Linguistic profile automated characterisation in pluripotential clinical high-risk mental state (CHARMS) conditions: methodology of a multicentre observational study." BMJ Open 13, no. 3 (2023): e066642. http://dx.doi.org/10.1136/bmjopen-2022-066642.

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IntroductionLanguage is usually considered the social vehicle of thought in intersubjective communications. However, the relationship between language and high-order cognition seems to evade this canonical and unidirectional description (ie, the notion of language as a simple means of thought communication). In recent years, clinical high at-risk mental state (CHARMS) criteria (evolved from the Ultra-High-Risk paradigm) and the introduction of the Clinical Staging system have been proposed to address the dynamicity of early psychopathology. At the same time, natural language processing (NLP) t

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Aguglia, Andrea, Antimo Natale, Benedetta Conio, et al. "Chronotype and Cardiometabolic Parameters in Patients with Bipolar Disorder: Preliminary Findings." Journal of Clinical Medicine 12, no. 17 (2023): 5621. http://dx.doi.org/10.3390/jcm12175621.

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Cardiometabolic alterations are very common in bipolar disorder (BD). The aim of this study was to investigate the relationship between chronotype and cardiometabolic parameters in patients with a primary diagnosis of BD. This study is an observational clinical investigation including 170 subjects consecutively admitted to the Psychiatric Inpatient Unit of the IRCCS Ospedale Policlinico San Martino (Genoa, Italy), recruited over a period of 48 months. A psychometric tool assessing chronotype was administered and blood tests were performed. Furthermore, the atherogenic coefficient ((total chole

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Murdaca, Giuseppe, Giovanni Noberasco, Alberto Battaglini, et al. "Systemic Sclerosis and Vaccinations: A Register-Based Cohort Study about Seasonal Influenza and Streptococcus pneumoniae Vaccination Rate and Uptake from Liguria Regional Center, Northwest Italy." Vaccines 8, no. 2 (2020): 204. http://dx.doi.org/10.3390/vaccines8020204.

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Systemic sclerosis (SSc) is the connective tissue disease with the highest mortality and patients with chronic inflammatory immune-mediated diseases are at high risk of acquiring infections as they are often treated with immunosuppressive or biological drugs. This study, conducted among the patients followed by our clinical immunology, part of the Internal Medicine Department in the Ospedale Policlinico San Martino, Genoa, northwest Italy, has set itself the primary objective of analyzing the vaccine uptake and the vaccination coverage against both seasonal influenza and S. pneumoniae in a coh

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Murdaca, Giuseppe, Sara Banchero, Marco Casciaro, et al. "Multiparametric Evaluation of Geriatric Patients Admitted to Intermediate Care: Impact on Geriatric Rehabilitation." Diagnostics 13, no. 18 (2023): 2906. http://dx.doi.org/10.3390/diagnostics13182906.

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Optimizing the functional status of patients of any age is a major global public health goal. Rehabilitation is a process in which a person with disabilities is accompanied to achieve the best possible physical, functional, social, intellectual, and relational outcomes. The Intermediate Care Unit within the O.U. of Geriatrics and Gerontology of the San Martino Hospital in Genoa is focused on the treatment and motor reactivation of patients with geriatric pathologies. The objective of this study was to identify which factor, among the characteristics related to the patient and those identified

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FREGATTI, PIERO, MARCO GIPPONI, MARIA GIACCHINO, et al. "Breast Cancer Surgery During the COVID-19 Pandemic: An Observational Clinical Study of the Breast Surgery Clinic at Ospedale Policlinico San Martino – Genoa, Italy." In Vivo 34, no. 3 suppl (2020): 1667–73. http://dx.doi.org/10.21873/invivo.11959.

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Amicizia, Daniela, Francesca Marchini, Paolo Pronzato, et al. "The Ligurian Experience in the Management of Lung Cancer: Organizational Models and New Perspectives." Healthcare 12, no. 24 (2024): 2556. https://doi.org/10.3390/healthcare12242556.

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Background: Lung cancer is an oncological threat worldwide, including in Italy. New organizational approaches based on a network of cancer centers and multidisciplinary and technological innovation are required. The experience in the Liguria region, in northwestern Italy, in the management of lung cancer is presented with a focus on the organizational model. Methods: A retrospective observational analysis was conducted for the period from January 2019 to December 2023 using administrative regional data. Results: Of the total surgery treatments in Liguria, most were carried out at the IRCCS San

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Vecchié, Alessandra, Aldo Bonaventura, Federico Carbone, et al. "C-Reactive Protein Levels at the Midpregnancy Can Predict Gestational Complications." BioMed Research International 2018 (November 7, 2018): 1–8. http://dx.doi.org/10.1155/2018/1070151.

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Although essential for a successful pregnancy, a growing body of evidence suggests that maternal inflammation, when dysregulated, may represent a risk factor for both maternal and neonatal outcomes. Here, we assessed the accuracy of maternal C-reactive protein (CRP) concentrations at the middle phase of pregnancy in the identification of maternal adverse outcomes (MAO) until delivery. A correlation between CRP and a complicated pregnancy including both maternal and neonatal adverse outcomes has been investigated, too. In this retrospective study, conducted at the Diabetology Unit of IRCCS Ospe

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Nappi, Francesco, Sandra Petiot, Antonio Salsano, et al. "Sex-Based Difference in Aortic Dissection Outcomes: A Multicenter Study." Journal of Cardiovascular Development and Disease 10, no. 4 (2023): 147. http://dx.doi.org/10.3390/jcdd10040147.

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Background: Type A Acute Aortic Dissection (TAAAD) repair is a surgical emergency associated with high morbidity and mortality. Registry data have noted several sex-specific differences in presentation with TAAAD which may account for the differences in men and women undergoing surgery for this condition. Methods: A retrospective review of data from three departments of cardiac surgery (Centre Cardiologique du Nord, Henri-Mondor University Hospital, San Martino University Hospital, Genoa) between January 2005 and 31 December 2021 was conducted. Confounders were adjusted using doubly robust reg

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Aguglia, Andrea, Giovanni Pietro Corsini, Alessandra Costanza, et al. "Sociodemographic and Clinical Correlates Associated with the Frequent Service Users in an Italian Psychiatric Emergency Department." Diagnostics 13, no. 3 (2023): 430. http://dx.doi.org/10.3390/diagnostics13030430.

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Background: The aim of the present study is to identify the main sociodemographic and clinical correlates associated with frequent service users (FSUs) in an Italian psychiatric emergency department. Methods: This study is an observational and prospective clinical investigation. All subjects (N = 549) consecutively admitted to the Psychiatric Inpatient Unit of the IRCCS Ospedale Policlinico San Martino ((Genoa, Italy) were recruited over a period of 18 months. Results: On average, FSUs were more likely to be single (75.0% vs. 64.0, p = 0.001), younger (38.79 years ± 14.68 vs. 45.94 years ± 16.

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GRIGNOLO, S., R. AGNELLO, D. GERBALDO, et al. "Pregnancy and neonatal outcomes among a cohort of HIV-infected women in a large Italian teaching hospital: a 30-year retrospective study." Epidemiology and Infection 145, no. 8 (2017): 1658–69. http://dx.doi.org/10.1017/s095026881700053x.

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SUMMARYThe primary study objective was to investigate three decades from 1985 to 2014 of changes in pregnancies among HIV-infected women. The secondary objective was to assess risk factors associated with preterm delivery and severe small-for-gestational-age (SGA) infants in HIV-infected women. A retrospective review of deliveries among pregnant HIV-infected women at the University of Genoa and IRCCS San Martino-IST in Genoa between 1985 and 2014 was performed. Univariate and multivariable analyses were used to study the variables associated with neonatal outcomes. Overall, 262 deliveries were

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Diaz, Raquel, Ilaria Baldelli, Letizia Cuniolo, et al. "Reducing Postoperative Complications in High-Risk Breast Surgery Patients: A Preliminary Study on the Efficacy of NPWT Dressing." Journal of Personalized Medicine 15, no. 3 (2025): 104. https://doi.org/10.3390/jpm15030104.

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Background: Negative Pressure Wound Therapy (NPWT) has proven to be an effective intervention in preventing postoperative complications across a range of surgical specialties, including orthopedics, vascular, and abdominal surgery. This study aimed to assess the prophylactic use of NPWT dressing compared to the Standard of Care (SOC) in high-risk patients undergoing oncoplastic and reconstructive breast surgery. Materials and Methods: This preliminary case-control study included 23 high-risk patients, enrolled between September 2023 and February 2024, at San Martino Polyclinic Hospital, Genoa.

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Kurita, Naoki, Francesco Frassoni, Nicoletta Sacchi, et al. "Quality of Cord-Blood Units and Hematological Recovery After Intra Bone CBT Are Not Influenced by the Bank of Origin and by the Time of Cryopreservation." Blood 118, no. 21 (2011): 4400. http://dx.doi.org/10.1182/blood.v118.21.4400.4400.

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Abstract Abstract 4400 BACKGROUND: Cord-blood transplantation (CBT) is an effective option for both malignant and non-malignant hematological diseases and its increasing number in the last years has enlarged the frequency of the use of cord-blood units (CBUs) trough international borders in order to maximize the opportunity of identifying optimal CB unit. Since there is no global standard regarding cord-blood quality control, the quality of CBUs can be affected by the bank of origin. In addition, few information are disposable on the cord blood engraftment capacity after long-term cryopreserva

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Martini, Mariano, and Giuseppe Martorana. "Luciano Giuliani (1928-1994): Great master and founding father of modern italian urology." Archivio Italiano di Urologia e Andrologia, May 22, 2023. http://dx.doi.org/10.4081/aiua.2023.11329.

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Luciano Giuliani was born near Arezzo, in Tuscany (Italy) in 1928. After taking his Degree cum Laude in Medicine and Surgery at the University of Florence in 1951, he became a voluntary assistant at the Institute of General Clinical Surgery and Surgical Therapy. He then took a diploma in Urology and General Surgery, having demonstrated his great technical and surgical ability, and was subsequently appointed assistant in charge and then extraordinary assistant. Endowed with uncommon surgical skills and a forceful personality, Giuliani tirelessly carried out his clinical and surgical activity, c

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DODARO, CARMINE, GIUSEPPE GALATÁ, ANDREA GRIONI, MARCO MARATEA, MARCO MOCHI, and IVAN PORRO. "An ASP-based Solution to the Chemotherapy Treatment Scheduling problem." Theory and Practice of Logic Programming, September 24, 2021, 1–17. http://dx.doi.org/10.1017/s1471068421000363.

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Abstract The problem of scheduling chemotherapy treatments in oncology clinics is a complex problem, given that the solution has to satisfy (as much as possible) several requirements such as the cyclic nature of chemotherapy treatment plans, maintaining a constant number of patients, and the availability of resources, for example, treatment time, nurses, and drugs. At the same time, realizing a satisfying schedule is of upmost importance for obtaining the best health outcomes. In this paper we first consider a specific instance of the problem which is employed in the San Martino Hospital in Ge

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Traverso, Nicola. "Experience of Integrative Medicine in the Hospice Ward of the University Hospital San Martino in Genoa, Italy." Online Journal of Complementary & Alternative Medicine 5, no. 5 (2021). http://dx.doi.org/10.33552/ojcam.2021.05.000623.

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Van Hal, G., L. Pigeaud, H. van Roozendaal, et al. "Differences and similarities in adolescents accessing emergency care for acute alcohol intoxication in three urban regions in Italy, Belgium, and The Netherlands." European Journal of Public Health 34, Supplement_3 (2024). http://dx.doi.org/10.1093/eurpub/ckae144.809.

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Abstract Background Excessive drinking among adolescents in Western Europe is prevalent, posing significant health risks and societal costs. Early initiation of alcohol use and binge drinking are associated with adult alcohol use disorders. Collecting comprehensive data on adolescent drinking patterns is crucial for developing effective prevention strategies. Methods To gain insight into the demographic and clinical characteristics of acute alcohol intoxication (AAI), we analysed emergency department access data of adolescents aged 14-17 years presenting with AAI symptoms from 2015-2023. Three

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Arcuri, Francesco, Emanuela Ardito, Ilaria Baldelli, Francesco Laganà, and Bernardo Bianchi. "Three-step Approach for Facial Reconstruction After Injectable Silicon: Surgical Excision, Fat Grafting, and Hyaluronic Acid Filler." Journal of Craniofacial Surgery, January 29, 2025. https://doi.org/10.1097/scs.0000000000011074.

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Introduction: In facial cosmetic surgery, injectable liquid silicone has been used to augment the cheek and the lips and to camouflage facial wrinkles. However, complications started to arise in 1964 as postoperative silicone granuloma formation. The purpose of this study is to introduce our experience in facial reconstruction after injectable silicon oil with a sequential 3-step approach: transoral surgical excision, full-face fat grafting, and hyaluronic acid filler. Methods: A retrospective study was conducted for all patients affected by facial granulomatosis due to liquid silicone injecti

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Ferrari, A., S. Mosca, M. Ogliastro, et al. "Alcohol related emergencies among adolescents admitted in a referral acute-care center for adults in Genoa, northwest Italy." European Journal of Public Health 34, Supplement_3 (2024). http://dx.doi.org/10.1093/eurpub/ckae144.806.

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Abstract Background As a result of underage drinking, adolescents have an increased risk of physical, mental, emotional, and social harm. Methods In order to assess the emergencies for alcohol use, data of the emergency department (ED) of San Martino Hospital - the referral acute-care center for adults in Genoa, Northwest Italy - was analyzed retrospectively. 330 records of 320 adolescents visiting the ED between 2014 and 2023 were considered. Results The median age of access was 16 (IQR 2), 54.8% were males, 17.4% had foreign nationalities, and the average blood alcohol concentration (BAC) wa

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Battaglini, A., A. Orsi, G. Icardi, S. Vyshka, F. Casabona, and G. Orengo. "Risk assessment in hematology ward renovation, a FMEA example in a tertiary hospital in Italy." European Journal of Public Health 30, Supplement_5 (2020). http://dx.doi.org/10.1093/eurpub/ckaa166.724.

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Abstract Background Hospital construction and renovation works cause derangement, increasing mistake rate in healthcare workers and resulting in dust contamination and dispersal of fungal spores that could improve morbidity and mortality in severely immune suppressed patients. The necessary renovation of hematology ward at IRCCS Policlinico San Martino in Genoa, scheduled for February 2020 required a risk assessment to avoid logistical, organizational and clinical problems. Two possible scenarios were proposed: (1) displacement of patients in another building previously used as hematological u

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Marri, Luca, Chiara Vassallo, Pasquale Esposito, Luca Bottaro, Raffaele De Palma, and Simone Negrini. "Clinical Characteristics of Systemic Lupus Erythematosus in Caucasians and Latin American Hispanics: Data from a Single Tertiary Center." Autoimmune Diseases 2024, no. 1 (2024). http://dx.doi.org/10.1155/2024/5593302.

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Background. Different studies report that systemic lupus erythematosus (SLE) tends to have a more aggressive course in Hispanic patients. In this study, we analysed epidemiologic, clinical, and laboratory characteristics in a cohort of Hispanic and Caucasian lupus patients in the context of Italian health service, which provides free access to care to all citizens, thus mitigating the impact of socioeconomic factors that negatively influence the course of the disease in ethnic minorities. Methods. This single‐center retrospective study was conducted at the San Martino Hospital “Lupus Clinic” i

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Pizzonia, Monica, Andrea Casabella, Marta Natali, et al. "Osteosarcopenia in Very Old Age Adults After Hip Fracture: A Real-World Therapeutic Standpoint." Frontiers in Medicine 8 (May 20, 2021). http://dx.doi.org/10.3389/fmed.2021.612506.

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Loss of bone and muscle mass and strength (i. e., osteosarcopenia) is a highly prevalent clinical condition in older adults, associated with an increased risk of fragility fractures and unfavorable clinical outcomes. Although sarcopenia is a potential risk factor for osteoporosis and subsequent fracture, and the management of this hazardous duet is the key to preventing osteoporotic fracture, evidence pertaining to the treatment of sarcopenia for the purpose of preventing fragile fractures remains insufficient. Given this scenario we aimed at prospectively compare the long-term effectiveness o

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Mahmoud, Mona, Luca Carmisciano, Luca Tagliafico, et al. "Patterns of Comorbidity and In-Hospital Mortality in Older Patients With COVID-19 Infection." Frontiers in Medicine 8 (September 17, 2021). http://dx.doi.org/10.3389/fmed.2021.726837.

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Introduction: Older adults are more susceptible to severe COVID-19, with increased all-cause mortality. This has been attributed to their multimorbidity and disability. However, it remains to be established which clinical features of older adults are associated with severe COVID-19 and mortality. This information would aid in an accurate prognosis and appropriate care planning. Here, we aimed to identify the chronic clinical conditions and the comorbidity clusters associated with in-hospital mortality in a cohort of older COVID-19 patients who were admitted to the IRCCS Policlinico San Martino

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Grammatico, F., F. Butera, I. G. Iavarone, et al. "RSV burden among hospitalized patients: 6-years surveillance of Liguria regional reference lab." European Journal of Public Health 29, Supplement_4 (2019). http://dx.doi.org/10.1093/eurpub/ckz186.522.

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Abstract Background Respiratory syncytial virus (RSV) represents one of the most common agent causing respiratory infections in infants and adults. It causes seasonal epidemics, with a peak prevalence in winter. RSV epidemiology and burden are still under-recognized, although it leads to complications and increased mortality in patients at risk, such as infants, pregnant women, the elderly and patients with chronic diseases. Materials/Methods Data analyzed in this study were collected during the virological surveillance system activities at the Policlinico San Martino university hospital in Ge

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Bruno, Francesco, Gabriele Crimi, Fabrizio D’ Ascenzo, et al. "426 Percutaneous or surgical access for transfemoral transcatheter aortic valve implantation: a propensity matched analysis of a multicentre registry." European Heart Journal Supplements 23, Supplement_G (2021). http://dx.doi.org/10.1093/eurheartj/suab134.007.

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Abstract Aims The transfemoral (TF) approach appeared to be the safest and the broadest used approach in TAVI, characterized by a lower rate of periprocedural bleedings and vascular complications and is currently recommended by the guidelines as a first line approach when feasible. If in the early experience TF access was achieved using a surgical cutdown approach, through the last years, there has been increasing evidence of the safety and efficacy of a fully percutaneous approach over a surgical access, albeit available evidences are controverting and mostly including first generation prosth

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Costa, E., L. Calabrese, A. Marchese, and V. Di Pilato. "<i>In vivo</i> emergence of cefiderocol resistance in <i>Pseudomonas aeruginosa</i> following prolonged treatment at San Martino Policlinico Hospital (HSM), Genoa, Italy." Microbiologia Medica 39, no. 2 (2024). https://doi.org/10.4081/mm.2024.13234.

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De Pace, Vanessa, Patrizia Caligiuri, Valentina Ricucci, et al. "Rapid diagnosis of SARS-CoV-2 pneumonia on lower respiratory tract specimens." BMC Infectious Diseases 21, no. 1 (2021). http://dx.doi.org/10.1186/s12879-021-06591-w.

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Abstract Background The ongoing SARS-CoV-2 pandemic requires the availability of accurate and rapid diagnostic tests, especially in such clinical settings as emergency and intensive care units. The objective of this study was to evaluate the diagnostic performance of the Vivalytic SARS-CoV-2 rapid PCR kit in lower respiratory tract (LRT) specimens. Methods Consecutive LRT specimens (bronchoalveolar lavage and bronchoaspirates) were collected from Intensive Care Units of San Martino Hospital (Genoa, Italy) between November 2020 and January 2021. All samples underwent RT-PCR testing by means of

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Robba, Chiara, Antonio Messina, Denise Battaglini, et al. "Early Effects of Passive Leg-Raising Test, Fluid Challenge, and Norepinephrine on Cerebral Autoregulation and Oxygenation in COVID-19 Critically Ill Patients." Frontiers in Neurology 12 (June 16, 2021). http://dx.doi.org/10.3389/fneur.2021.674466.

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Background: Coronavirus disease 2019 (COVID-19) patients are at high risk of neurological complications consequent to several factors including persistent hypotension. There is a paucity of data on the effects of therapeutic interventions designed to optimize systemic hemodynamics on cerebral autoregulation (CA) in this group of patients.Methods: Single-center, observational prospective study conducted at San Martino Policlinico Hospital, Genoa, Italy, from October 1 to December 15, 2020. Mechanically ventilated COVID-19 patients, who had at least one episode of hypotension and received a pass

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Forte, Paolo, Jennifer Cattaneo, Felice Cardillo Piccolino, et al. "Influence of scleral thickness on photodynamic therapy outcomes in central serous chorioretinopathy." Acta Ophthalmologica, October 20, 2024. http://dx.doi.org/10.1111/aos.16779.

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AbstractPurposeTo test the prognostic role of anterior scleral substantia propria (ASSP) thickness in predicting the 3‐month response after half‐dose photodynamic therapy (PDT) in central serous chorioretinopathy (CSCR) and to assess its clinical relevance of ASSP in different CSCR phenotypes.MethodsA prospective, exploratory, multi‐centre cohort study conducted at IRCCS San Martino Hospital (Genoa, Italy) and Jules‐Gonin Eye Hospital (Lausanne, Switzerland). Demographic and clinical data, and optical coherence tomography (OCT) were collected at baseline and 3 months after PDT. Based on OCT im

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Russo, Chiara, Luca Tagliafico, Laura Labate, et al. "1942. Effect of SARS-CoV-2 Vaccination in a Frailty COVID-19 Cohort: a Real Life Experience in a Northern Italy Hospital." Open Forum Infectious Diseases 9, Supplement_2 (2022). http://dx.doi.org/10.1093/ofid/ofac492.1569.

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Abstract Background Clinical trial demonstrated that SARS-CoV-2 vaccines have the ability of reduce mortality and morbidity due to COVID-19. The aim of this study is to describe the effect of vaccination in term of mortality, type of ventilation and ICU admission among patients hospitalized for COVID-19 from May to December 2021 in a Ligurian Hospital. Methods This is a retrospective, single-center study conducted in San Martino Hospital (Genoa, Italy), including patients ≥ 18 years hospitalized for COVID-19 in Infectious Disease and Emergency Units from 1st May to 31st December 2021. We colle

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Cappadona, Francesca, Filippo Sangregorio, Laura Mallia, et al. "#6104 CLINICAL IMPACT OF UNDIAGNOSED HOSPITAL ACUTE KIDNEY INJURY." Nephrology Dialysis Transplantation 38, Supplement_1 (2023). http://dx.doi.org/10.1093/ndt/gfad063a_6104.

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Abstract Background and Aims Hospital Acute kidney injury (H-AKI) is associated with an increased risk of complications and mortality. Despite attempts to uniform the diagnosis of AKI and point attention to this condition, in clinical practice, the recognition of AKI is often limited. In this study, we tried to evaluate the impact of underdiagnosed AKI in hospitalized patients. Method We collected data of patients hospitalized at IRCSS Policlinico San Martino, Genoa, Italy, between 1/1/2106 and 31/12/2019. We considered clinical data, serum creatinine (sCr), length of hospital stay, death, com

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"CO33 | Acquired hemophilia A in Liguria, Italy: what six years of data reveal." Bleeding, Thrombosis and Vascular Biology 4, s1 (2025). https://doi.org/10.4081/btvb.2025.240.

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Background and Aims: Acquired hemophilia A (AHA) is a rare autoimmune bleeding disorder caused by the development of autoantibodies that target various epitopes on the factor VIII (FVIII) molecule. These autoantibodies inhibit FVIII’s coagulation activity and accelerate its clearance. AHA remains a significant challenge for clinicians, as many physicians often poorly recognize it. This hampers its diagnosis and likely leads to an underestimation of both its prevalence and incidence. The Liguria Region has a total population of 1,565,307 people thus the estimated incidence of new diagnoses of A

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Robba, Chiara, Lorenzo Ball, Denise Battaglini, et al. "Early effects of ventilatory rescue therapies on systemic and cerebral oxygenation in mechanically ventilated COVID-19 patients with acute respiratory distress syndrome: a prospective observational study." Critical Care 25, no. 1 (2021). http://dx.doi.org/10.1186/s13054-021-03537-1.

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Abstract Background In COVID-19 patients with acute respiratory distress syndrome (ARDS), the effectiveness of ventilatory rescue strategies remains uncertain, with controversial efficacy on systemic oxygenation and no data available regarding cerebral oxygenation and hemodynamics. Methods This is a prospective observational study conducted at San Martino Policlinico Hospital, Genoa, Italy. We included adult COVID-19 patients who underwent at least one of the following rescue therapies: recruitment maneuvers (RMs), prone positioning (PP), inhaled nitric oxide (iNO), and extracorporeal carbon d

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Robba, Chiara, Danilo Cardim, Lorenzo Ball, et al. "The Use of Different Components of Brain Oxygenation for the Assessment of Cerebral Haemodynamics: A Prospective Observational Study on COVID-19 Patients." Frontiers in Neurology 12 (December 20, 2021). http://dx.doi.org/10.3389/fneur.2021.735469.

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Introduction: The role of near-infrared spectroscopy (NIRS) for the evaluation of cerebral haemodynamics is gaining increasing popularity because of its noninvasive nature. The aim of this study was to evaluate the role of the integral components of regional cerebral oxygenation (rSO2) measured by NIRS [i.e., arterial-oxyhemoglobin (O2Hbi) and venous-deoxyhemoglobin (HHbi)-components], as indirect surrogates of cerebral blood flow (CBF) in a cohort of critically ill patients with coronavirus disease 2019 (COVID-19). We compared these findings to the gold standard technique for noninvasive CBF

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Romano, Paolo DM. "Bioinformatics activities at the University Hospital San Martino IST in Genoa." April 28, 2017. https://doi.org/10.14806/ej.23.0.884.

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Trombetta, Carlo-Simone, Marco Bongiovanni, Giulia Gatti, et al. "Antimicrobial resistance surveillance at ospedale policlinico san martino irccs, genoa north-west italy: A focus on meticillin-resistant staphilococcus aureus." Population Medicine 5, Supplement (2023). http://dx.doi.org/10.18332/popmed/164521.

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Baldoni, Erica, Elvira Massaro, Oriana Ferrante, et al. "Analysis of Emergency Room accesses at IRCCS Ospedale Policlinico San Martino, Genoa, north-west Italy: differences between Italian and foreigner Liguria residents." Population Medicine 5, Supplement (2023). http://dx.doi.org/10.18332/popmed/164524.

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