Academic literature on the topic 'San Nicolás'
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Journal articles on the topic "San Nicolás"
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Palombini, Giancarlo. "Dall’etnomusicologia all’acustemologia." Anuac 7, no. 1 (July 24, 2018): 217–23. http://dx.doi.org/10.7340/anuac2239-625x-3384.
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Nota critica di Nicola Scaldaferri, ed, Santi, animali e suoni: Feste dei campanacci a Tricarico e San Mauro Forte, 1 CD allegato, Udine, Nota, Geos cd book, Musica e cultura tradizionale della Basilicata, 4, 2005, pp. 96; Nicola Scaldaferri, Steven Feld, eds, I suoni dell’albero: Il Maggio di S. Giuliano ad Accettura, 2 CD allegati, Udine, Nota, Geos cd book, Musica e cultura tradizionale della Basilicata, 6, 2012, pp. 132.
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Giuffrida, Dario, Viviana Mollica Nardo, Daniela Neri, Giovanni Cucinotta, Irene Vittoria Calabrò, Loredana Pace, and Rosina Celeste Ponterio. "A Multi-Analytical Study for the Enhancement and Accessibility of Archaeological Heritage: The Churches of San Nicola and San Basilio in Motta Sant’Agata (RC, Italy)." Remote Sensing 13, no. 18 (September 17, 2021): 3738. http://dx.doi.org/10.3390/rs13183738.
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In the coming years, Italy will need to take on a great challenge concerning the digitization of its archaeological and architectural heritage, one of the richest and most problematic in the world. The aim is to improve the knowledge, conservation, enhancement and accessibility of cultural assets and to make them a resource for national and local development. In this process, the next generation of 3D survey methods (laser scanning and photogrammetry), in combination with diagnostic techniques (spectroscopy analyses) and GIS/BIM (Geographic Information System/Building Information Modeling) solutions, represent a valid support. This work, part of a broader intervention launched by the Municipality of Reggio Calabria for the requalification of some archaeological sites located within its urban and metropolitan area, is focused on the study case of Motta S. Agata. The ancient settlement is located 8 km from Reggio C. in a hilly area difficult to reach and preserves numerous structures in a state of ruin. Among these, two interesting medieval churches are proposed for examination: the church of San Nicola, characterized by five hypogeal funeral crypts, and the chapel of San Basilio, which preserves the traces of a wall painting. A multi-methodological approach including close-range photogrammetry, laser scanning and chemical and thermal analyses was adopted in order to fulfill different tasks: creating a topographic model of the hillfort, mapping the archaeological evidence, digitizing and returning 3D models of the churches, characterizing materials through chemical analyses and monitoring the surfaces with thermal imaging. These combined applications have contributed to reaching the planned goals, i.e., study, conservation, diagnostics, preparation for restoration interventions, development of digital media and dissemination. In this way, a type of interactive museum (made up of virtual tours and informative digital models) has been made available in order to improve the site’s accessibility and inclusivity as well as to test the effect of digitization in attracting tourists and local people toward a place located outside of the usual tourist circuits.
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Mariano, F., M. Saracco, and L. Petetta. "THE SEAPLANE BASE IVO MONTI AT S. NICOLA VARANO (FG): A MONUMENT OF MILITARY ARCHEOLOGY, BETWEEN HISTORY AND PROTECTION." ISPRS - International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLII-5/W1 (May 16, 2017): 419–25. http://dx.doi.org/10.5194/isprs-archives-xlii-5-w1-419-2017.
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Built in the years between 1915 and 1918, and located on the west bank of the “Varano” Lake, a bay running along the village of “Cagnano Varano”, the “Ivo Monti” seaplane base was erected on a pre-existing medieval settlement which belonged to the Benedictine Monks from the town of “San Nicola Imbuti”. <br><br> During WWI, this seaplane base was turned, from a simple water airport, into a strategic military base for floatplanes. As a matter of fact, the large lagoon could be used as landing spot for the planes sent off to patrol the dalmatic coast, one of the historical regions of Croatia, then controlled by the Austrians. <br><br> After WWI, after the seaplane became an outdated technology, the “Ivo Monti” base was progressively dismantled and then totally abandoned at the beginning of the 1950s. <br><br> In 2014, considering the historical relevance of this site and the unmistakable architectural value of its elements, a research framework agreement was signed between the “DICEA” Department of Marche Polytechnic University and the city council of the town hosting the site, aimed at the development of shared scientific research projects revolving around the study, the valorisation, and the restoration of the military complex in question, which had been in a complete state of decay and neglect for too long. <br><br> The still ongoing research project mentioned presents two main missions: the first is the historical reconstruction, the geometric mapping, and the robustness analysis of the ruins, by studying and faithfully representing the state of deterioration of the building materials and of the facilities; the second is the identification and the testing of potential architectural solutions for the conversion and the reuse of the site and of its facilities.
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Wade, Mark, Emiliano Tamanini, Mathieu Unbekandt, Nicola Wallis, John Lyons, Joanne Munck, Andrew Woodhead, et al. "Abstract 5902: Targeting MAPK-driven tumors via inhibition of MAP2K4." Cancer Research 84, no. 6_Supplement (March 22, 2024): 5902. http://dx.doi.org/10.1158/1538-7445.am2024-5902.
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Abstract MAPK pathway activation is a feature of multiple tumor types. Drugging KRAS and BRAF, the two main oncogenic drivers in the MAPK pathway, has proven successful in the clinic. Inhibition of the downstream effectors, MEK and ERK, can also induce tumor regression. Despite this, many tumors are intrinsically resistant to MAPK pathway inhibitors, or acquire resistance under selective pressure to drug treatment. This creates a need for combination treatments to improve clinical responses. A synthetic lethal (SL) interaction between inhibition of the MAPK pathway and blockade of JNK-JUN signaling has recently been described1. Specifically, data from yeast genetics and CRISPR knockout experiments in human cells have identified MAP2K4 as a potential therapeutic target that could be combined with MAPK inhibitors. To date, however, no potent MAP2K4 inhibitors with in vitro and cellular selectivity against key anti-targets have been reported. Here, we describe the development of potent covalent inhibitors of MAP2K4 kinase activity. Biochemical and cell-based assays show that the compound(s) are selective for MAP2K4 versus anti-targets including MAP2K7 and ERK kinases. The combination of MAP2K4 and MEK/ERK inhibitors was effective in cell lines driven by MAPK signaling. These data provide the rationale for further development of MAP2K4 inhibitors to advance our understanding of this novel drug combination. References: 1. Xue Z, Vis DJ, Bruna A, Sustic T, van Wageningen S, Batra AS, et al. MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models. Cell Res. 2018; 28:719-29. Citation Format: Mark Wade, Emiliano Tamanini, Mathieu Unbekandt, Nicola Wallis, John Lyons, Joanne Munck, Andrew Woodhead, Patrick Schopf, Jessie Stow, Charlotte East, Mellissa Clark, Jeffrey St. Denis, Puja Pathuri. Targeting MAPK-driven tumors via inhibition of MAP2K4 [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 5902.
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Willmore, Elaine, Maria Ahn, Suzanne Kyle, Yan Zhao, Huw Thomas, Kenneth S. Rankin, Luke Bevan, et al. "Abstract 3333: Targeting the MDM2-p53 interaction: Time- and concentration-dependent studies in tumor and normal human bone marrow cells reveal strategies for an enhanced therapeutic index." Cancer Research 84, no. 6_Supplement (March 22, 2024): 3333. http://dx.doi.org/10.1158/1538-7445.am2024-3333.
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Abstract Aim We aimed to design an MDM2-p53 antagonist with a differentiated tolerability profile that could be used to treat patients with wild-type TP53 malignancies. As part of an alliance between Newcastle University, Astex Pharmaceuticals, and Cancer Research Horizons, we discovered ASTX295, a potent inhibitor of the MDM2-p53 interaction that is currently under clinical investigation in patients with solid tumors (NCT03975387). We selected ASTX295 as a compound with a predicted short plasma half-life, which we hypothesised would help to mitigate the dose-limiting neutropenia and thrombocytopenia observed with earlier MDM2-p53 antagonists in clinical studies. To examine this hypothesis in vitro, we determined time- and concentration-dependent responses to ASTX295 treatment in healthy volunteer-derived human bone marrow cells, megakaryocytes, and in a panel of human tumor cell lines. Methods Samples containing bone marrow cells from healthy patients undergoing hip surgery were obtained under the ethical approval of the Newcastle Biobank (REC 12/NE/0395). Following Lymphoprep™ separation, cells were treated ex vivo with ASTX295 and seeded for Granulocyte-macrophage (GM) colony-forming assays in methylcellulose. Megakaryocytes were obtained from in vitro differentiation of CD34+ stem/progenitor cells. Human tumor cell lines (including MDM2-amplified SJSA-1) were treated with ASTX295 in vitro and seeded at low density for colony-forming assays. Exposures of 6, 12, or 24h were examined, and the data plotted to calculate LC50 values. Results The clonogenic survival of tumor cells was time-dependent, with LC50 values (mean ± SEM) in SJSA1 cells being 238 ± 46nM and 75 ± 7nM respectively (n = 3-4), following a 12h or 24h exposure to ASTX295. Time-dependent effects were also evident in five human bone marrow samples but with LC50 values of 1.9, >3, >10, >10, and >10uM being achieved at 12h, and 860 ± 268nM at 24h. Megakaryocytes showed similar time-dependent sensitivities in which daily treatment of 2 or 6h over three days did not induce apoptosis while significant cell death was observed when the treatment time was extended to 16-24h daily. In contrast, short, daily pulse treatment of 2-6h in cell lines (MV4-11, MOLM-13, SJSA-1) over three days was sufficient to induce cell death. Conclusions ASTX295 is a potent antagonist of the MDM2-p53 interaction. Collectively, our in vitro data suggest that a shorter exposure to ASTX295 (up to 12h), may help to spare healthy bone marrow cells whilst killing tumor cells. Hence, intermittent exposure to an MDM2-p53 antagonist could favourably modulate its therapeutic index. The predicted short plasma half-life of ASTX295 should provide flexibility in controlling the duration of exposure in vivo, potentially enabling a more bone-marrow sparing approach to MDM2-p53 antagonism to be utilised. Citation Format: Elaine Willmore, Maria Ahn, Suzanne Kyle, Yan Zhao, Huw Thomas, Kenneth S. Rankin, Luke Bevan, Lynsey Fazal, Keisha Hearn, Nicola Wilsher, Justyna Kucia-Tran, Nicola Ferrari, Nicola Wallis, Neil Thompson, John Lyons, Duncan Miller, Celine Cano, Martin E. Noble, Ian R. Hardcastle, Steven Howard, Gianni Chessari, John Lunec, David R. Newell, Steve R. Wedge. Targeting the MDM2-p53 interaction: Time- and concentration-dependent studies in tumor and normal human bone marrow cells reveal strategies for an enhanced therapeutic index [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 3333.
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Schenker, Adrian. "S. Schirone – R. Scognamiglio, Nessun altro debito che l’Amore. Prestito e usura nell’ Antico Testamento (Fondazione Antiusura San Nicola e Santi Medici-Bari), Rom (Ed. VIVERE IN) 1995, 122p., L. 9000; ISBN 88-083-5." Biblische Zeitschrift 44, no. 2 (April 5, 2000): 309. http://dx.doi.org/10.1163/25890468-04402031.
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Lippi, Lorenzo, Alessandro de Sire, Arianna Folli, Francesco D’Abrosca, Alessio Turco, Giuseppina Bonizzi, Nicola Fusco, and Marco Invernizzi. "Abstract P5-08-08: Ultrasound-guided injection with or without rehabilitation exercise in breast cancer survivors with sub-acromion-deltoid bursitis: a pilot randomized clinical study." Cancer Research 83, no. 5_Supplement (March 1, 2023): P5–08–08—P5–08–08. http://dx.doi.org/10.1158/1538-7445.sabcs22-p5-08-08.
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Abstract BACKGROUND: Due to the increasing overall survival of breast cancer (BC) patients, a growing interest has been raised in the current literature on disabling consequences of cancer and its treatment [1,2]. In particular, after radical surgery for BC, patients might frequently be affected by functional limitation of the shoulder joint, potentially related to the immobilization, surgical scar tensions, axillary web syndrome, subpectoral prostheses or expanders, or peripheral nerve damage [3]. In this scenario, several challenges are still open in the therapeutic approach to this disabling condition and the optimal management of shoulder dysfunction in breast cancer patients is far from being fully characterized. Therefore, the aim of this study was to assess the effects of a comprehensive rehabilitation program including ultrasound-guided injection of the sub-acromion deltoid bursa (SAD) followed by a rehabilitation exercise protocol in terms of feasibility, pain relief, upper limb function, quality of life, and safety. METHODS: In this study, we recruited consecutive breast cancer women referring to a Physical Medicine and Rehabilitation in Northern Italy and suffering from SAD bursitis in the absence of tendon lesions. Patients were assessed for eligibility and subsequently randomly assigned 1:1 to two groups. Group A received ultrasound-guided percutaneous injection of the SAD bursa (lidocaine and triamcinolone acetate) followed by a rehabilitation exercise program of 5 sessions lasting 1 hour each., while Group B received ultrasound-guided percutaneous injection only. Patients were assessed at baseline (T0), after a week (T1), and after 3 months (T2). The outcomes were numerical pain rating scale (NPRS), handgrip strength (HGS) test, European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30), the Oxford Shoulder Score (OSS), Global Perceived Effect (GPE), and safety. RESULTS: Thirty-seven patients were enrolled and randomly assigned to Group A (n=19; mean age: 56.05 ± 10.30 years; body mass index (BMI): 23.58 ± 2.79 kg/m2) and Group B (n=18; mean age: 58.39 ± 12.09 years; BMI: 22.72 ± 3.16 kg/m2). No major or minor adverse events were reported after this multidisciplinary intervention. Statistically significant within-group differences were found in both groups in terms of NPRS after the treatment (p < 0.05) and after the follow-up (p < 0.05). The between-group analysis showed significant differences in pain intensity (NRS: 2.16 ± 1.39 vs 4.78 1.77; p < 0.05), isometric muscle strength (25.11 3.20 vs 20.33 4.92; p< 0.001), shoulder function (OSS: 17.00 3.27 vs 33.11 6.471; p< 0.0001), and EORTC QLQ-C30 (Functional subscale: 88.74 7.71 vs 77.67 13.64; p=0.017; Symptom subscale: 11.43 8.56 vs 19.61 13.72; p=0.048; Global Health subscale: 79.36 13.72 vs 70.56 8.26; p=0.022) of the after the follow-up. However, no significant differences (p > 0.05) were reported at T1. CONCLUSION: Our findings showed that a comprehensive rehabilitation approach including ultrasound-guided injection combined with rehabilitation exercise might be safe, well-tolerated, and effective in breast cancer patients with SAD bursitis. These data emphasized the positive role of an interdisciplinary rehabilitation management in pain management and improving overall well-being of breast cancer patients. Further studies with larger samples and longer follow-ups are needed to confirm our data. REFERENCES: 1. Nardin S et al. Breast Cancer Survivorship, Quality of Life, and Late Toxicities. Front Oncol 2020, 10, 864. 2. D’Egidio V et al. Counseling interventions delivered in women with breast cancer to improve health-related quality of life: a systematic review. Qual Life Res 2017, 26, 2573-2592, doi:10.1007/s11136-017-1613-6. 3. Hidding JT et al. Treatment related impairments in arm and shoulder in patients with breast cancer: a systematic review. PLoS One. 2014 May 9;9(5):e96748. Citation Format: Lorenzo Lippi, Alessandro de Sire, Arianna Folli, Francesco D’Abrosca, Alessio Turco, Giuseppina Bonizzi, Nicola Fusco, Marco Invernizzi. Ultrasound-guided injection with or without rehabilitation exercise in breast cancer survivors with sub-acromion-deltoid bursitis: a pilot randomized clinical study [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P5-08-08.
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Reduzzi, Carolina, Eleonora Nicolo, Lauren L. Ozimski, Marco Silvestri, Lorenzo Gerratana, Mara S. Serafini, Elisabetta Molteni, et al. "Abstract 3693: Molecular and functional characterization of circulating CK+/CD45+ cells in breast cancer." Cancer Research 84, no. 6_Supplement (March 22, 2024): 3693. http://dx.doi.org/10.1158/1538-7445.am2024-3693.
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Abstract Background: Circulating tumor cells (CTCs) are considered a key element in metastatic progression and represent a validated prognostic biomarker in breast cancer (BC). CTCs in BC are normally defined as epithelial cells (positive for EPCAM or cytokeratin, CK) lacking the expression of the leukocyte marker CD45. Circulating cells expressing both EPCAM/CK and CD45 (dual positive, DPcells) have however been reported in BC but not investigated. It is believed that DPcells derive from the heterotypic cell fusion of tumor and immune cells, but this hypothesis has not been demonstrated yet. We recently reported, for the first time, the association of DPcells with worse survival in a cohort of 341 BC patients (pts) [Reduzzi et al. ASCO 2022] supporting their tumor origin. Here, we further investigated their malignancy and metastatic potential by molecular profiling and functional experiments. Methods: The study consisted of 2 components: A) Single CTCs and DPcells were enriched from the blood of BC patients with the CellSearch platform, and isolated with the DEPArray system. Single cells underwent whole genome amplification and lowpass whole genome sequencing for single cell copy number alteration (CNA) profiling; B) DPcells and CTCs were investigated in the blood of immunodeficient (NSG) and immunocompetent (FVB) mouse models using various cell lines (LM2, 4T1, MVT1). To test their metastatic potential, DPcells from the primary tumor of FVB donor mice were transplanted into recipient NSG mice, and the metastatic burden in the lungs and liver quantified, in comparison with control CD45- tumor cells. Results: We analyzed 73 DPcells and 18 CTCs collected from 16 BC pts: Aberrant genomes were observed in 28% and 93% of evaluable cells, respectively. When collected from the same pt, CTCs showed clonal CNA profiles, while DPcells were highly heterogeneous. In vivo, DPcells could only be detected in the blood of FVB mice but not in NSG mice. They were very rare, comprising of only about 3% of the total CTC count. When DPcells and control tumor cells were isolated from the primary tumor of 10 donor mice and transplanted into the tail vein of 10 recipient mice, we observed no significant differences in the metastatic colonization of the lungs and liver by the two population, indicating that DPcells do in fact possess metastatic ability, and to a similar extent as control cancer cells. Conclusions: DPcells can have an aberrant genome, supporting their malignancy. Contrary to CTCs, DPcells’ CNA profiles are not clonal and, in vivo, they can only be observed in immunocompetent models; both observations support the tumor/immune fusion hypothesis. Finally, DPcells show metastatic potential in mice, in line with the association with worse survival we previously observed in BC pts. Overall DPcells seem a new CTC subpopulation that should not be neglected anymore. More studies are needed to better understand their origin and phenotypic/molecular features. Citation Format: Carolina Reduzzi, Eleonora Nicolo, Lauren L. Ozimski, Marco Silvestri, Lorenzo Gerratana, Mara S. Serafini, Elisabetta Molteni, Nadia Bayou, Amanda K. Strickland, Huiping Liu, Vera Cappelletti, Nicola Aceto, Massimo Cristofanilli. Molecular and functional characterization of circulating CK+/CD45+ cells in breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 3693.
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McBain, Kirsty, Gillian Lovell, Jasmine Trigg, Nicola Bevan, and Daniel Appledorn. "Abstract 4722: Enhanced phenotypic screening: A kinetic, multiplexed approach to analyzing drug effects using Incucyte® Live-Cell Analysis System." Cancer Research 84, no. 6_Supplement (March 22, 2024): 4722. http://dx.doi.org/10.1158/1538-7445.am2024-4722.
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Abstract Phenotypic screening is a valuable tool for analysis of the complex mix of effects that drug treatment has on cells. Traditionally image-based screening uses fixed cells stained with reagents at a pre-chosen end point, however our technique combines kinetic, label-free readouts with non-perturbing fluorescence reporters to enable information-rich quantification of compound effects. A549 lung cancer cells were treated with a library of over 800 FDA-approved drugs while images were acquired in the Incucyte® Live-Cell Analysis System every two hours for four days. Cell growth and viability were measured using label-free readouts of confluence and dead cell count while cell cycle, cell death and Akt pathways were investigated using multiplexed fluorescent readouts. Cytotoxicity was measured using label-free Incucyte® AI Cell Health Analysis Software Module which uses two neural networks to segment individual cells and classify them as live or dead. Assay robustness was quantified using the time course of positive and negative controls (camptothecin and vehicle, respectively). Z’ reached a maximal value >0.9 between 48h and 72h; at 72h 4.4% of the compounds within the library induced >50% cell death. Correlation between % Live cells and % Confluence indicated 3 types of effect: cytotoxic (low viability, low confluence), cytostatic (high viability, low confluence), and none (high viability, high confluence). Morphological changes were observed in a multitude of wells with 29 compounds inducing cell enlargement >1800 µm2, suggesting induction of senescence. Hits from fluorescent readouts were identified as the compounds which perturbed the quantified readout more than 3 standard deviations away from the mean value of the vehicle. Mechanisms of cell death were examined by correlative analysis of the total dead cell population (label-free cell death identification), caspase-active (caspase 3/7-reagent positive) and Annexin V positive cells. This enabled rapid identification of compounds which induced apoptosis by caspase-independent pathways, including the serotonin-selective reuptake inhibitor Sertraline. Kinetic plots of cell cycle stage (% S|G2|M or G1) revealed contrasting mechanisms. Mycophenolic acid induced cell cycle arrest, observed as a consistent increase in the percentage of cells in G1 over time. However flumazenil displayed repeated, transient peaks in the percentage of cells in S|G2|M over the same 72h period, indicating synchronisation behavior. Incucyte® Live-Cell Analysis System as a phenotypic screening platform provides valuable kinetic data from cells within the physiologically relevant environment of a standard incubator. Label-free readouts yield direct cellular information and can be combined with fluorescent data to provide vastly more information than a single endpoint readout. Citation Format: Kirsty McBain, Gillian Lovell, Jasmine Trigg, Nicola Bevan, Daniel Appledorn. Enhanced phenotypic screening: A kinetic, multiplexed approach to analyzing drug effects using Incucyte® Live-Cell Analysis System [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 4722.
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Vetter, Marcus, Bich Doan Ngyuen-Sträuli, Ilona Krol, Alexander Ring, Angela Kohler, Francesc Castro-Giner, Maren Vogel, et al. "Abstract PO5-18-04: Effect of Digoxin on clusters of circulating tumor cells in patients with metastatic breast cancer (DICCT)." Cancer Research 84, no. 9_Supplement (May 2, 2024): PO5–18–04—PO5–18–04. http://dx.doi.org/10.1158/1538-7445.sabcs23-po5-18-04.
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Abstract Background: The presence of circulating tumor cell (CTC) clusters is associated with tumor progression and with a bad prognosis in various cancer types1,2. In breast cancer, a pre-clinical model demonstrated that Na/K-ATPase inhibitors such as digoxin could dissolve CTC clusters and reduce metastasis3. DICCT is a single-arm, therapeutic exploratory phase I study aimed to examine whether digoxin can disrupt CTC clusters in metastatic breast cancer patients (NCT03928210). Material and methods: Metastatic breast cancer patients in whom clusters of CTCs have been detected were eligible. Patients with concomitant heart disease were excluded. After progressive disease in any line of therapy, a window of opportunity before initiation of subsequent systemic therapy was used to administer digoxin treatment for seven (7) days. For CTC detection, blood samples were processed with the FDA-cleared Parsortix system (ANGLE plc, UK). Captured CTCs were stained for EPCAM, HER2, EGFR (positive CTC selection) and CD45 (exclusion marker). To gain insight into the cluster-dissolution ability of digoxin, the primary endpoint was size of CTC clusters (i.e. number of cells within each cluster) under digoxin therapy. The cumulative effect of digoxin treatment on the primary endpoint was assessed by a linear regression model. Results: Nine (9) patients with CTC clusters detected at baseline were enrolled. A target level of digoxin above 0.7 ng/ml could be confirmed at day 7 for all patients. For quantitative and qualitative analysis of CTC clusters, 5.5 to 27 ml of blood were analyzed at baseline, at day 0 pre-treatment, and post 2 hours, 3 days and 7 days of digoxin treatment. The average cluster size ranged between 2 and 11.8 cells (median 2.9) considering all samples from all patients. Digoxin treatment reduced cluster size in 8 patients (88.9%) to different extents, and the proportion of CTC cluster over single CTCs was also reduced in 6 patients (66.7%). The effect of digoxin was evident in both homotypic (cancer cells only) and heterotypic (aggregates of CTCs and white blood cells) clusters. The treatment was well tolerated, and no adverse events related to the study treatment occurred. All patients completed the treatment according to the protocol. Conclusion: DICCT provides the first-in-human proof-of-principle that digoxin induces a partial dissolution of CTC clusters in patients with metastatic breast cancer at drug levels that are safe and well tolerated. Conceptualization of follow-up trials including Na/K-ATPase inhibitors and patient outcome endpoints are underway. References: 1. Ring A, Nguyen-Strauli BD, Wicki A, Aceto N. Biology, vulnerabilities and clinical applications of circulating tumour cells. Nat Rev Cancer 2022:1-17. DOI: 10.1038/s41568-022-00536-4. 2. Schuster E, Taftaf R, Reduzzi C, Albert MK, Romero-Calvo I, Liu H. Better together: circulating tumor cell clustering in metastatic cancer. Trends Cancer 2021;7(11):1020-1032. DOI: 10.1016/j.trecan.2021.07.001. 3. Gkountela S, Castro-Giner F, Szczerba BM, et al. Circulating Tumor Cell Clustering Shapes DNA Methylation to Enable Metastasis Seeding. Cell 2019;176(1-2):98-112 e14. DOI: 10.1016/j.cell.2018.11.046. Citation Format: Marcus Vetter, Bich Doan Ngyuen-Sträuli, Ilona Krol, Alexander Ring, Angela Kohler, Francesc Castro-Giner, Maren Vogel, Cvetka Grasic Kuhar, Fabienne Schwab, Viola Heinzelmann-Schwarz, Gabriela Kuster Pfister, Walter Weber, Christian Kurzeder, Nicola Aceto. Effect of Digoxin on clusters of circulating tumor cells in patients with metastatic breast cancer (DICCT) [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO5-18-04.
Books on the topic "San Nicolás"
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Dotoli, Giovanni. Storia e leggenda della basilica di San Nicola a Bari. [Fasano (Brindisi)]: Schena, 1987.
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Cioffari, Gerardo. Pellegrini a San Nicola di Bari nella storia. Bari: Centro studi nicolaiani, 2007.
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Angelo, Saponara, and Fiorino Fulvia, eds. Storia e leggenda della Basilica di San Nicola a Bari. Fasano: Schena, 1987.
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Daquino, Cesare. Bizantini di Terra d'Otranto: San Nicola di Casole. Lecce: Capone, 2000.
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Scandale, Eugenio. Lo scrigno del tesoro di San Nicola di Bari. Bari: M. Adda, 2009.
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Walter, Scotucci, ed. La cona ritrovata della basilica di San Nicola a Tolentino. Tolentino: Collana di Studi in onore di Luigi Centanni, 2002.
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Giorgio, Otranto, ed. San Nicola di Bari e la sua Basilica: Culto, arte, tradizione. Milano: Electa, 1987.
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Centro studi "Agostino Trapè.", ed. La Basilica di San Nicola a Tolentino: Guida all'arte e alla storia. Tolentino: Biblioteca egidiana, Convento San Nicola, 1995.
Find full textBook chapters on the topic "San Nicolás"
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Brodie, Thomas L. "The Quest for Sources: The Central Problem." In The Quest For The Origin Of John ‘s Gospel, 25–29. Oxford University PressNew York, NY, 1993. http://dx.doi.org/10.1093/oso/9780195075885.003.0005.
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Abstract It is generally agreed that the fourth gospel is based to a significant extent on some form of predecessor, an older document which contained a basic narrative concerning Jesus and which acted as a backbone or foundation for the present text. There is deep uncertainty however concerning the identity of that predecessor. Some would say that it was the gospel of Mark (cf. esp. Barrett, 42-54; 1974), others that it was the evangelist ‘s own first edition (cf. esp. Brown, xxxv), and still others that it was some form of a document which put a special emphasis on Jesus ‘ miracles or signs (the “signs source” or Gospel of Signs). Taken in isolation, Brown ‘s idea of an earlier edition is quite possible, but it remains vague, and it is part of a larger theory which, as Schnackenburg implied (1977, 23-24), is difficult to verify. Furthermore, as one begins to appreciate the unity of the text, such claims about processes of redaction seem unnecessary and inappropriate. The shape attributed to the signs source varies greatly. In particular there is not agreement as to whether it contained a passion narrative. Earlier researchers (e.g. Bultmann, Nicol, Schnackenburg), despite their considerable differences, generally contended that it did not (for references, see von Wahlde, 1989, 194-96; Becker, 112-13; Bois mard ‘s “Document C,” 1977, 16-19, is exceptional).
Conference papers on the topic "San Nicolás"
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Sabina, Macovei, Acasandrei Leonard, and Mariana Mezei. "COMPUTERIZED ELECTRONIC BAROPODOMETRY - A MODALITY TO EVALUATE THE SPINAL COLUMN DYSFUNCTIONS IN PERFORMANCE ATHLETES." In eLSE 2013. Carol I National Defence University Publishing House, 2013. http://dx.doi.org/10.12753/2066-026x-13-228.
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AUTHORS: Prof. PhD Sabina MACOVEI1, Assist. Lecturer PhD Student Leonard ACASANDREI1, PhD Student Mariana MEZEI1 National University of Physical Education and Sports, Bucharest Introduction Computerized baropodometry represents a technique specialized in the analysis of the distribution and measurement of plantar pressure exerted by different somatic structures, through an electronic recording platform. Determinant for the foot mechanics study, it provides objective data related to the body center of gravity distribution and, implicitly, to the possible dysfunctions at the spinal column level. Purpose Relying on some case studies, the present paper aims at using the electronic baropodometry, as an efficient modality to objectify the vertebral column dysfunctions in performance girl gymnasts, by considering their high incidence in this sports branch, with negative effects on the quality of life. Content In our study, we used the FootscanSystem device (developed by the Belgian Company "RSscan International") based on the Footscan Software 7.97 Gait 2nd Generation, to determine the plantar pressure distributions in the bipodal static situation and during the gate support phase. We conducted our research at "Dr. Nicolae Robănescu" National Medical Center for Children's Rehabilitation in Bucharest and our subjects were the girl gymnasts from the Sports Club of UNEFS Bucharest. Conclusions Electronic baropodometry represents a unique and accurate evaluation tool that can be used to identify the forefoot or the rear-foot plantar pressure distribution, the maximum pressure points, the forefoot deviation tendency in supination or pronation, the way in which the center of gravity is distributed on each foot, as well as the association of some pathologies such as the spinal column dysfunctions or imbalances at the pelvis level. References 1. Capelle, P., 2001, Exploración clínica elemental en podología, Enciclopedia Médico Quirúrgica Elsevier SAS, Paris,1-5; 26-161-A-12. 2. Epuran, M., 2005, Metodologia cercetării activităţilor corporale, Ediţia a II-a, Editura Fest, Bucureşti. 3. Libotte, M., 2001, Podoscopia electrónica, Enciclopedia Médico Quirúrgica Elsevier SAS, París 1-5; 26-161-A-13. 4. Macovei S., Acasandrei L., 2012, Theoretical and methodical considerations regarding the spine imbalances in different sports disciplines, XIIth International scientific conference Perspectives in physical education and sport, 19 May 2012, Constanta. 5. Martinez, A.P., 2005, Anomalías baropodometricas en jugadores de baloncesto de elite, Archivos de medicina del deporte, Volumen XXII, Numero 107, pag. 177-185. 6. Navarro N. E., 2002, Lesiones deportivas en el aeróbic de competición, Revista Apunts: Medicina de l esport, Numero 139, pag. 31-37. 7. Padilla, A. H., 2006, Uso de la baropodometria, Revista MedigraphicArtemisa, Volumen 2, Numero 4, Octubre-Deciembre, pag. 256-261. 8. Rodriguez Fernandez, R., 2009, Baropodometría Electrónica, Revista de investigación, tecnica y educativa, Nr. 9, ISSN: 1989-354X, Deposito Legal: SE 545-2009.
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Montoya, Catalina, Lina María Escobar-Ocampo, and Claudia María Vélez-Venegas. "Marinilla´s cultural landscape and spacial characterization (Colombia)." In 24th ISUF 2017 - City and Territory in the Globalization Age. Valencia: Universitat Politècnica València, 2017. http://dx.doi.org/10.4995/isuf2017.2017.6201.
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Marinilla´s cultural landscape and spacial characterization (Colombia). Catalina Montoya Arenas¹, Lina María Escobar Ocampo¹, Claudia Maria Venegas Velez¹ ¹Facultad de Arquitectura, UPB. Circular 1 N°70-01 Medellin, Colombia. E-mail: catalina.montoyaarenas@upb.edu.co, lina.escobar@upb.edu.co, claudia.ve7@gmail.com Keywords (3-5): Cultural landscape, social management, heritage, spacial transformations, tourism Conference topics and scale: Stages in territorial configuration The historic center of Marinilla, National Monument since 1959, is located sixty minutes from Medellin at San Nicolas Valley. It has exceptional landscape conditions, highly productive lands, and a large percentage of the water reserve that supplies the region and the country, giving the territory an economic center character since the colony. These physical values make part of collective imagination as a recreation area and an opportunity for development in the 1960s, according to the construction of large national infrastructure works. At the same time, it was object of armed conflict in the 1980s and 1990s, and more recently, directly related to the spatial dynamics of the region: unplanned urban expansion, changes in land use and vegetation cover, with effects on the cultural landscape. In a post-conflict situation, the economic strategies of different actors trust on tourism as a social-spatial management strategy to improve the territory. However, the identity of rurality shows spatial imbalances without recognizing elements of historical construction whose legacies must be revealed to ensure equitable development. To do this, we propose an approach from the cultural landscape in a revision of the historical, symbolic and relational transformation through five systems (anthropic, productive, political, symbolic and spatial), analyzing competitiveness, tourism, landscape and social management, in different scales and during three historical moments. References (100 words) Busquets, J., and Cortina, A. (2009). Gestión del paisaje: Manual de protección, gestión y ordenación del paisaje. Ariel, Barcelona. Sierra, P. A. (2003). Periferias y nueva ciudad: el problema del paisaje en los procesos de dispersión urbana. Universidad de Sevilla. Barrera, S. (2014). Consideraciones teóricas para el análisis del paisaje. La Metodología de Los eventos relacionales. Perspectivas sobre el paisaje. Varón, D. C. Z. (2015). El derecho al paisaje en Colombia.: Consideraciones para la definición de su contenido, alcance y límites. U. Externado de Colombia. Olmo, R. M. (2008). El paisaje, patrimonio y recurso para el desarrollo territorial sostenible. Conocimiento y acción pública. Arbor, 184(729).
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De Gortari Ludlow, Jimena, and Margarita Cuellar Barona. "Documentando lo intangible, las voces de la ciudad en los Barrio San Nicolás, Cali y Del Carmen, Ciudad de México." In ISUF-h 2019 - CIUDAD COMPACTA VERSUS CIUDAD DIFUSA. Valencia: Editorial Universitat Politècnica de València, 2019. http://dx.doi.org/10.4995/isufh2019.2019.9947.
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La experiencia sensorial tuvo un papel importante en el análisis de la ciudad en el mundo pre moderno. No obstante, la progresiva racionalización del conocimiento trajo consigo el dominio de la visión sobre otros sentidos convirtiéndonos en una sociedad oculocentrista. Sabemos que la ciudad no se vive de igual manera, por tanto debemos considerar la experiencia sensorial como parte fundamental en la construcción de la memoria del lugar e incorporarla como una capa más en los estudios de la forma urbana. A través del estudio comparativo de la experiencia de escucha de dos barrios latinoamericanos (San Nicolás en Cali, Colombia y Coyoacán en Ciudad de México) este trabajo pretende poner de manifiesto el papel que juega el sonido en la conformación de los espacios sociales urbanos, en el impacto sobre la calidad de vida y en las representaciones mentales que los y las habitantes de las ciudades construyen de sus entornos. El texto presenta una metodología de trabajo en la que se apela a la memoria, al relato, al recuerdo, a la referencia, al vínculo de lo tangible con lo intangible; a esa(s) ciudad(es) que no se puede(n) entender sin analizar la relación que existe entre las personas que habitan el espacio y el espacio en sí, del espacio como anhelo y como experiencia; en donde el sonido cobra un significado relevante y que al documentarse permitirá entender el vínculo que tienen los habitantes con el espacio público.
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De Gortari Ludlow, Jimena, and Margarita Cuellar Barona. "Documentando lo intangible, las voces de la ciudad en los Barrio San Nicolás, Cali y Del Carmen, Ciudad de México." In ISUF-h 2019 - CIUDAD COMPACTA VERSUS CIUDAD DIFUSA. Valencia: Editorial Universitat Politècnica de València, 2020. http://dx.doi.org/10.4995/isufh2019.2020.9947.
Full textAbstract:
La experiencia sensorial tuvo un papel importante en el análisis de la ciudad en el mundo pre moderno. No obstante, la progresiva racionalización del conocimiento trajo consigo el dominio de la visión sobre otros sentidos convirtiéndonos en una sociedad oculocentrista. Sabemos que la ciudad no se vive de igual manera, por tanto debemos considerar la experiencia sensorial como parte fundamental en la construcción de la memoria del lugar e incorporarla como una capa más en los estudios de la forma urbana. A través del estudio comparativo de la experiencia de escucha de dos barrios latinoamericanos (San Nicolás en Cali, Colombia y Coyoacán en Ciudad de México) este trabajo pretende poner de manifiesto el papel que juega el sonido en la conformación de los espacios sociales urbanos, en el impacto sobre la calidad de vida y en las representaciones mentales que los y las habitantes de las ciudades construyen de sus entornos. El texto presenta una metodología de trabajo en la que se apela a la memoria, al relato, al recuerdo, a la referencia, al vínculo de lo tangible con lo intangible; a esa(s) ciudad(es) que no se puede(n) entender sin analizar la relación que existe entre las personas que habitan el espacio y el espacio en sí, del espacio como anhelo y como experiencia; en donde el sonido cobra un significado relevante y que al documentarse permitirá entender el vínculo que tienen los habitantes con el espacio público.