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Journal articles on the topic 'Sangeetha*'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Ashok Kumar, Sangeetha, Jaya Seeli Shankar, Bhuvana K. Periyasamy, and Sanjay K. Nayak. "Correction: Role of defective states in MgO nanoparticles on the photophysical properties and photostability of MEH-PPV/MgO nanocomposite." Physical Chemistry Chemical Physics 23, no. 43 (2021): 24944. http://dx.doi.org/10.1039/d1cp90213j.

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Correction for ‘Role of defective states in MgO nanoparticles on the photophysical properties and photostability of MEH-PPV/MgO nanocomposite’ by Sangeetha Ashok Kumar et al., Phys. Chem. Chem. Phys., 2021, 23, 22804–22816, DOI: 10.1039/d1cp03035c.

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Chalil, Suada Poolayulla, Maneesha Kunnathattil, Sangeetha G. Kaimal, and Thejass Punathil. "A checklist of spider mites (Acari: Tetranychidae) of India." Persian Journal of Acarology 13, no. 1 (2024): 29–75. https://doi.org/10.22073/pja.v13i1.78022.

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Chalil, Suada Poolayulla, Kunnathattil, Maneesha, Kaimal, Sangeetha G., Punathil, Thejass (2024): A checklist of spider mites (Acari: Tetranychidae) of India. Persian Journal of Acarology 13 (1): 29-75, DOI: 10.22073/pja.v13i1.78022, URL: https://www.mendeley.com/catalogue/7445d22f-6ba9-3f3c-81f9-b4aa7435220a/

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Srinivasan, Bikshandarkoil R., S. Natarajan, and Guddeangadi N. Gururaja. "Comments on the papers recently published by Sangeetha et al." Journal of Thermal Analysis and Calorimetry 120, no. 2 (2015): 1071–75. http://dx.doi.org/10.1007/s10973-015-4501-8.

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4

Naples, Nancy A., and Manisha Desai. "The Empowerment of Women in India: Grassroots Women's Networks and the State. Sangeetha Purushothaman." American Journal of Sociology 105, no. 5 (2000): 1494–96. http://dx.doi.org/10.1086/210449.

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5

Ashmita, Biswas. ""Love was no sin": Negotiating Transgressive Desire and Colonial Specters in Sangeetha Sreenivasan's Acid (2018)." Criterion: An International Journal in English 15 (December 31, 2024): 212–22. https://doi.org/10.5281/zenodo.14605845.

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In Sangeetha Sreenivasan’s novel <em>Acid</em> (2018) the colonial specters are subtle, but loud. The research undertaken reveals how the narrative lays bare the failure of the post-colony as it proactively orchestrates the lives of the characters who find themselves to be at the mercy of biopolitical forces. As Sreenivasan weaves her tale around the lesbian affair between Kamala, a married woman and mother of two, and Shaly, a woman who belongs to no one, the postcolonial anxieties surrounding heterosexual constructs of femininity reveal themselves. Kamala is a deviation from the tradit

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Mrs., V. Sangeetha, and Swarnamuki K. "A cram on the interpretation of myth in Ngugi's "The River Between"." International Journal of Trend in Scientific Research and Development 2, no. 3 (2018): 1122–23. https://doi.org/10.31142/ijtsrd11301.

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A myth is a traditional story consisting of events that are ostensibly historical, though often supernatural, explaining the origins of a cultural practice or natural phenomenon. The word myth is derived from the Greek word mythos, which simply means story . Mythology can refer either to the study of myths, or to a body or collection of myths. It can mean sacred story, traditional narrative or tale of the gods. A myth can also be a story to explain why something exists. Mrs. V. Sangeetha | K. Swarnamuki "A cram on the interpretation of myth in Ngugi's "The River Between"&quo

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M., Sangeetha* Dr. P. Sengottuvelan. "SOFTWARE REFACTORING COST ESTIMATION USING PARTICLE SWARM OPTIMIZATION." INTERNATIONAL JOURNAL OF RESEARCH SCIENCE & MANAGEMENT 4, no. 6 (2017): 43–49. https://doi.org/10.5281/zenodo.583651.

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“Now a day’s software industry major development cost devoted software maintenance. The major challenge for this industry is to produce quality software which is timely designed and build with proper cost estimates. Refactoring is used increasing the ability of software to adopt the new requirements and maintenance In this paper, we have proposed a cost estimation model based on Multi-objective Particle Swarm Optimization (MPSO) to tune the parameters of the famous Constructive Cost Model (COCOMO). This cost estimation model is integrated with Quality Function Deployment (QFD) methodology to s

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Rajendran, Sangeetha, and B. Kalpana. "Improvised Admissible Kernel Function for Support Vector Machines in Banach Space for Multiclass Data." INTERNATIONAL JOURNAL OF COMPUTERS & TECHNOLOGY 11, no. 2 (2013): 2273–78. http://dx.doi.org/10.24297/ijct.v11i2.1173.

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Classification based on supervised learning theory is one of the most significant tasks frequently accomplished by so-called Intelligent Systems. Contrary to the traditional classification techniques that are used to validate or contradict a predefined hypothesis, kernel based classifiers offer the possibility to frame new hypotheses using statistical learning theory (Sangeetha and Kalpana, 2010). Support Vector Machine (SVM) is a standard kernel based learning algorithm where it improves the learning ability through experience. It is highly accurate, robust and optimal kernel based classifica

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V., Sangeetha, and Suganthi B. "A Search for Identity in Margaret Laurence's A Jest of God." International Journal of Trend in Scientific Research and Development 2, no. 3 (2018): 370–72. https://doi.org/10.31142/ijtsrd11009.

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Margaret Laurence is a prolific and distinguished novelist hailing from Canada she focuses on the fixes of women and efforts to give an individuality to the Canadian women. The theme of resolution resides a essential place in the novels of Margaret Laurence who hails from Scots Irish circumstantial of firm standards and hard work and Puritanism. In her Manawaka novels, Laurence has given us unforgettable portraits of women wrestling with their private demons, striving through introspection to find meaningful patterns, in their lives. A jest of god is one of the Manawaka novels. The story of wo

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Mr., CP. Senthil Kumar, and T. Sangeetha Dr. "A Study on Relationship between Achievement Motivation and Academic Achievement in English among High School Students." International Journal of Trend in Scientific Research and Development 3, no. 4 (2019): 1343–48. https://doi.org/10.5281/zenodo.3591073.

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The aim of this longitudinal study was to Relationship between Achievement Motivation and Academic Achievement in English among High School Students. A sample of 300 students participated in the study. Results of structural equation modeling showed that mastery goals approach and avoidance were indirect predictors of both behavioral and cognitive engagement through seeking help from teachers. Performance goals avoidance, but not approach orientation were associated with cognitive engagement through help seeking behaviors. Overall, these results suggest that achievement goals are key drivers of

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Abu Aqil, Ibrahim Ibrahim. "The degree to which faculty members in Palestinian universities possess digital competence in light of the Corona pandemic." Arab Journal for Quality Assurance in Higher Education 15, no. 52 (2023): 29–47. http://dx.doi.org/10.20428/ajqahe.v15i52.2048.

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This research aims to Identified to the extent to which faculty members in Palestinian universities possess digital competence in light of the Corona pandemic, as a stratified sample of (300) faculty members was selected, and the questionnaire that he made (Sangeetha and Saileela, 2021) was developed and used to detect Digital competence, and the results showed that the degree of possession of digital competencies by faculty members in Palestinian universities came to a medium degree, and they use e-mail and browsing, social media and to direct students to follow the course, and their ability

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M., Sangeetha, Arivoli R., and Karthikeyan B. "A New breed NN Based UHVDC for Offshore Wind Power Plant to Enhance the Transient Response." International Journal of Trend in Scientific Research and Development 2, no. 2 (2018): 1095–102. https://doi.org/10.31142/ijtsrd9580.

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In proposed system transient management of offshore wind power plant can be achieved by unified high voltage direct current transmission HVDC system. This advance HVDC transmission system rectifies the defect of recent AC transmission network. The design of HVDC system made up of both series and shunt compensator call by unified HVDC UHVDC . It assures the smooth power transfer, Direct current link voltage regulation and fast fault clearance during transient conditions. The former control of Unified HVDC is designed by synchronous reference frame technique SRF which leads poor performance in f

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Krishnaveni, Venugopal, and Dharmalingam Sangeetha. "Development of electrospun Ti incorporated polyvinyl pyrrollidone nanofiber and its characterizations." Journal of Indian Chemical Society Vol. 92, May 2015 (2015): 652–55. https://doi.org/10.5281/zenodo.5702481.

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Department of Mechanical Engineering, Anna University, Guindy, Chennai-600 025, India <em>E-mail </em>: sangeetha@annauniv.edu In recent years, electrospinning has garnered a lot of interest in the production of ultra fine continuous polymer fibers of varying diameters. The main goal of this study was to prepare a novel bipolar membrane using metal incorporated hydrophilic polymer nanofiber mat as an intermediate so as to investigate the effects of the hydrophilic interface on water splitting efficiency. The technique used for the nanofiber preparation is by electrospinning method and the poly

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LNU, Pushpalatha, O. Syamala, Rukshana LNU, K. Sangeetha, and G. Usha Rani. "Vaginal Reconstruction in Müllerian Agenesis with User- Friendly Indigenous Prosthetic Vaginal Dilators." Journal of SAFOMS 2, no. 2 (2014): 75–78. http://dx.doi.org/10.5005/jp-journals-10032-1046.

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ABSTRACT Objective Vaginal reconstruction in Müllerian agenesis through nonsurgical method, using serial vaginal dilators which were worn by the patients with the help of a T-shaped perineal bandage. Materials and methods Seven patients with Müllerian agenesis had attended the outpatient clinic between 2008 and 2013. The age of women ranged from 18 to 30 years. This clinical report describes the use of prosthesis, fabricated by a maxillofacial prosthodontist that enabled the patients to have custom made personalized vaginal dilators of increasing dimensions which they could wear with comfort w

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15

Arriaga, Moises. "Book Review: Otology Demystified: A Diagnostic Oto-Endoscopic Colour Atlas: Vijayendra Honnurappa, Sangeetha Ramadass, Nilesh Mahajan, and Vinay Kumar Vijayendra; 2022, Bangalore, India." Otology & Neurotology 44, no. 1 (2022): 1. http://dx.doi.org/10.1097/mao.0000000000003727.

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Yan, Kevin, Md Kamran Chowdhury Shisher, and Yin Sun. "A Transfer Learning-Based Deep Convolutional Neural Network for Detection of Fusarium Wilt in Banana Crops." AgriEngineering 5, no. 4 (2023): 2381–94. http://dx.doi.org/10.3390/agriengineering5040146.

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During the 1950s, the Gros Michel species of bananas were nearly wiped out by the incurable Fusarium Wilt, also known as Panama Disease. Originating in Southeast Asia, Fusarium Wilt is a banana pandemic that has been threatening the multi-billion-dollar banana industry worldwide. The disease is caused by a fungus that spreads rapidly throughout the soil and into the roots of banana plants. Currently, the only way to stop the spread of this disease is for farmers to manually inspect and remove infected plants as quickly as possible, which is a time-consuming process. The main purpose of this st

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17

Siddiqui, Rehana. "Sangeetha Purshothaman. The Empowerment of Women in India— Grassroots Women’s Network and the State. New Delhi: Sage Publications, 1998. Hardbound. Indian Rs 450.00. Paperback. Indian Rs 250.00. 384 pages." Pakistan Development Review 37, no. 2 (1998): 193–97. http://dx.doi.org/10.30541/v37i2pp.193-197.

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This study discusses the impact of the new organisational structure emerging in India to improve the status of rural women. The objectives of the study are twofold: first, it intends to explore the possibility of small organisations working together to have an impact at the local level; the second issue is the sustainability of such an arrangement. The study concentrates on the experience of the Swayam Shaikshan Prayog (SSP) in the Indian state of Maharashtra. The basic theme of this organisational set-up is that women know best what they want and what solutions work for them. The SSP’s networ

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18

Nair, Prashant. "QnAs with Sangeeta N. Bhatia." Proceedings of the National Academy of Sciences 117, no. 3 (2020): 1243–45. http://dx.doi.org/10.1073/pnas.1922176117.

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Palanisamy, Gopinath S., Chandregowda Venkateshappa, Megha Goyal, et al. "Abstract A044: The discovery of potent KAT6 inhibitors that demonstrate anti-tumor activity in preclinical models of ER+ breast cancer." Molecular Cancer Therapeutics 22, no. 12_Supplement (2023): A044. http://dx.doi.org/10.1158/1535-7163.targ-23-a044.

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Abstract KAT6 paralogs KAT6A (MOZ; MYST3) and KAT6B (MORF; MOZ2; MYST4) are histone acetyltransferase (HAT) enzymes that acetylate histone H3 and thereby epigenetically regulate gene transcription by altering chromatin structure. Dysregulation of KAT6 activity (gene amplification, overexpression, fusion, mutation, etc.) is observed in breast and other cancers. In several subtypes of breast cancer, KAT6A is amplified as part of the 8p11-p12 amplicon and/or is overexpressed in 11 to 15% of overall breast cancer population. Overexpression of KAT6 correlates with worse clinical outcome in ER+/HER2

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20

Deo, Aditya Pratap. "Book review: Sangeeta Dasgupta, Reordering Adivasi Worlds: Representation, Resistance, Memory." Indian Economic & Social History Review 60, no. 2 (2023): 229–31. http://dx.doi.org/10.1177/00194646231170440.

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21

Geetha, B. "Book review: Rohit K. Dasgupta and Sangeeta Datta, 100 Essential Indian Films." South Asia Research 40, no. 2 (2020): 304–6. http://dx.doi.org/10.1177/0262728020915557.

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Chatterjee, Indrani. "Book review: Sangeeta Dasgupta, Reordering Adivasi Worlds: Representation, Resistance, Memory." Studies in History 38, no. 2 (2022): 188–91. http://dx.doi.org/10.1177/02576430221120315.

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23

Savyasaachi. "Book review: Sangeeta Dasgupta. 2022. Reordering Adivasi Worlds: Representation, Resistance, Memory." Contributions to Indian Sociology 56, no. 2 (2022): 229–32. http://dx.doi.org/10.1177/00699667221125866.

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24

Singla, Naresh. "Book review: Sangeeta Verma and P. C. Bodh (Eds.). 2018. Glimpses of Indian Agriculture." Millennial Asia 9, no. 3 (2018): 336–40. http://dx.doi.org/10.1177/0976399618805630.

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Bhattacharyya, Arun, Sangeeth Varghese, and Amit Gupta. "Sangeeth Varghese: a dilemma of democratization and detachment." Emerald Emerging Markets Case Studies 10, no. 1 (2020): 1–25. http://dx.doi.org/10.1108/eemcs-02-2019-0017.

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Learning outcomes Learning outcomes are as follows: understanding the importance of aligning an entrepreneur’s personal orientation and values (e.g. detachment from the enterprise) with business decisions related to enterprise development; appreciating how prior exposure to business settings can be a source of entrepreneurship pursuits for an entrepreneur; and understand whether a different type of leadership can be instrumental in the creation, running and growth of an entrepreneurial venture, especially in terms of introducing differentiated offerings in the target market. Case overview/syno

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Guillaume-Pey, Cécile. "Sangeeta Dasgupta, Reordering Adivasi Worlds. Representation, Resistance, Memory." Archives de sciences sociales des religions, no. 204 (December 31, 2023): 184–87. http://dx.doi.org/10.4000/assr.73484.

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Trivedi, Bhumika, and Rajesh G. Kelkar. "Influence of Western Music on Rabindra Sangeet in context with Global Music – A Study." Naad Nartan Journal of Dance and Music 12, no. 1 (2024): 94–97. https://doi.org/10.5281/zenodo.11189993.

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<em>This study will present a comprehensive look at different modes of Rabindra Sangeet and Western music in context with Global </em><em>Music. The purpose is to traverse the influence of western music on Rabindra Sangeet through the spiritual significance of </em><em>Rabindra Sangeet by Guru Rabindranath Tagore. The objective of the research is to explore different songs of Rabindra Sangeet </em><em>having western influence at different levels. ‘Valmiki Pratibha’, ‘Kalamrigaya’ and different parjaay’s songs come to mind </em><em>when mentioning Rabindra Sangeet

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McArthur, Heather, Elizabeth Comen, Yolanda Bryce, et al. "Abstract OT1-19-01: A Single Arm Phase 2 Study of Peri-Operative Checkpoint-Mediated Immune Therapy and Cryoablation in Women with Hormone Receptor-Negative, HER2-Negative Early Stage/Resectable Breast Cancer." Cancer Research 83, no. 5_Supplement (2023): OT1–19–01—OT1–19–01. http://dx.doi.org/10.1158/1538-7445.sabcs22-ot1-19-01.

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Abstract Background: Local tumor destruction with cryoablation (cryo) induces inflammation and releases antigens that can activate tumor-specific immune responses. Pre-clinically, cryo with immune checkpoint inhibition (ICI)-augmented tumor-specific immune responses and prevented recurrence. Clinically, we established that peri-operative (peri-op) cryo with ipilimumab (ipi) +/- nivolumab (nivo) was not only safe in patients (pts) with operable, early stage breast cancer (ESBC) but also generated robust intra-tumoral and systemic immune responses. In this phase 2 study, we evaluate the disease

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Li, Hu, Ren-Huai Dai, and Zi-Zhong Li. "Description of Sangeeta sinuomacula sp. nov. (Hemiptera: Cicadellidae: Megophthalminae: Agalliini) from Yunnan Province of Southwest China." Zootaxa 3974, no. 1 (2015): 129–34. https://doi.org/10.11646/zootaxa.3974.1.10.

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Li, Hu, Dai, Ren-Huai, Li, Zi-Zhong (2015): Description of Sangeeta sinuomacula sp. nov. (Hemiptera: Cicadellidae: Megophthalminae: Agalliini) from Yunnan Province of Southwest China. Zootaxa 3974 (1): 129-134, DOI: 10.11646/zootaxa.3974.1.10

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McArthur, Heather, Jorge Henrique Santos Leal, Christina DiLauro Abaya, et al. "Abstract OT3-25-01: Neoadjuvant HER2-targeted Therapy +/- Immunotherapy with Pembrolizumab (neoHIP): An Open Label Randomized Phase II Trial." Cancer Research 83, no. 5_Supplement (2023): OT3–25–01—OT3–25–01. http://dx.doi.org/10.1158/1538-7445.sabcs22-ot3-25-01.

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Abstract Background: Immune checkpoint inhibition (ICI) is synergistic with HER2-directed therapy in pre-clinical models. Clinically, pembrolizumab (K)-mediated ICI plus HER2-directed therapy with trastuzumab (H) was safe and demonstrated modest activity in H-resistant HER2-positive (HER2+) metastatic breast cancer. Because ICI may confer more robust activity when administered earlier in the course of disease, H and K administered in the curative-intent, treatment-naive setting may allow for de-escalation of cytotoxic chemotherapy; confer life-long, tumor-specific immunity; and ultimately, imp

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McArthur, Heather, Elizabeth Comen, Yolanda Bryce, et al. "Abstract PO5-19-07: A Single Arm Phase 2 Study of Peri-Operative Immune Checkpoint Inhibition and Cryoablation in Women With Hormone Receptor-Negative, HER2-Negative Early Stage/Resectable Breast Cancer." Cancer Research 84, no. 9_Supplement (2024): PO5–19–07—PO5–19–07. http://dx.doi.org/10.1158/1538-7445.sabcs23-po5-19-07.

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Abstract Background: Triple negative breast cancer (TNBC) is a biologically distinct subtype with a high risk of early relapse. Patients not achieving a pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) have a 3-year event free survival (EFS) of &lt; 60%. Approximately 1/3 of patients receiving NAC with pembrolizumab-mediated immune therapy will not achieve a pCR and of those, approximately 1/3 will experience a recurrence within 3 years. Physical disruption of tumors with local strategies such as cryoablation (cryo) induces inflammation and releases antigens that c

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Basumatary, Paris, John T.D. Caleb, Sangeeta Das, Ashish Kumar Jangid, Jatin Ka Lita, and Dulur Brahma. "First record of the genus Vailimia Kammerer, 2006 from India, with the description of two new species (Araneae: Salticidae: Plexippina)." Zootaxa 4790, no. 1 (2020): 178–86. https://doi.org/10.11646/zootaxa.4790.1.11.

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Basumatary, Paris, Caleb, John T.D., Das, Sangeeta, Jangid, Ashish Kumar, Lita, Jatin Ka-, Brahma, Dulur (2020): First record of the genus Vailimia Kammerer, 2006 from India, with the description of two new species (Araneae: Salticidae: Plexippina). Zootaxa 4790 (1): 178-186, DOI: 10.11646/zootaxa.4790.1.11

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Vences, Miguel, Aurélien Miralles, Sophie Brouillet, et al. "iTaxoTools 0.1: Kickstarting a specimen-based software toolkit for taxonomists." Megataxa 6, no. 2 (2021): 77–92. https://doi.org/10.11646/megataxa.6.2.1.

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Vences, Miguel, Miralles, Aurélien, Brouillet, Sophie, Ducasse, Jacques, Fedosov, Alexander, Kharchev, Vladimir, Kostadinov, Ivaylo, Kumari, Sangeeta, Patmanidis, Stefanos, Scherz, Mark D., Puillandre, Nicolas, Renner, Susanne S. (2021): iTaxoTools 0.1: Kickstarting a specimen-based software toolkit for taxonomists. Megataxa 6 (2): 77-92, DOI: 10.11646/megataxa.6.2.1

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Lynch, Monica P. "Sangeet kaar/Musician: Artist’s Statement." Academic Medicine 84, no. 1 (2009): 12. http://dx.doi.org/10.1097/acm.0b013e3181906edc.

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Fujie, Linda, and Radio France. "Inde du Norde. Sangeet Trio en concert [North India. The Sangeet Trio in Concert.]." Yearbook for Traditional Music 29 (1997): 208. http://dx.doi.org/10.2307/768345.

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Editor, The. "Annex 2: An Accolade to Late Gopal Singh Nepali." Himalayan Journal of Sociology and Anthropology 3 (November 25, 2008): 174–76. http://dx.doi.org/10.3126/hjsa.v3i0.1504.

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The editors of the current issue would like to extend their heartiest thanks to Mr. Sanjeev Nepali and Ms. Sangeeta Nepali, the Children of Prof. G.S. Nepali for providing important materials for preparing this accolade.DOI: http://dx.doi.org/10.3126/hjsa.v3i0.1504 Himalayan Journal of Sociology and Anthropology Vol.III, Sept. 2008 p.174-176

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McFarland, Jesse M., Amir Mahmoodi, Michael Zakharian, Sangeetha Srinivasan, Nathan A. Yee, and José M. Mejía Oneto. "Abstract 1894: Click Activated Protodrugs Against Cancer (CAPAC™): A modular platform for tumor directed oncology therapeutics." Cancer Research 82, no. 12_Supplement (2022): 1894. http://dx.doi.org/10.1158/1538-7445.am2022-1894.

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Abstract The CAPAC platform aims to help patients beat cancer by activating powerful cancer therapies at the tumor site(s). The core click chemistry technology is agnostic to therapeutic agent or indication. The modular nature of the platform allows targeting strategies based on tumor’s location, antigens, or both to be combined with therapeutics utilizing multiple mechanisms of action to deliver highly effective treatments tailored to each patient. The lead clinical candidate SQ3370 consists of a tetrazine-modified sodium hyaluronate biopolymer (SQL70) that is injected at the tumor site and f

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Prabhakaran, Sangeetha, Christopher McNicoll, Vernon S. Pankratz, et al. "Abstract 3686: Differences in disease presentation, and treatment outcomes of neoadjuvant chemotherapy for breast cancer among Hispanics in a minority-serving institution." Cancer Research 82, no. 12_Supplement (2022): 3686. http://dx.doi.org/10.1158/1538-7445.am2022-3686.

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Abstract Background: Response to neoadjuvant chemotherapy (NAC) for breast cancer varies by tumor characteristics and therapy regimen. Studies suggest that patient ethnicity is associated with differences in disease presentation, response to treatment, and outcomes. There exists a paucity of literature on the presentation and outcomes of NAC for breast cancer in Hispanic women. Methods: This is an IRB-approved retrospective study of breast cancer patients who underwent NAC at an NCI-designated Comprehensive Cancer Center from 2005-2020. We reviewed demographics, disease presentation, response

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Oneto, Jose M. Mejia, Sangeetha Srinivasan, Jesse M. McFarland, Matthew Tso, and Masa Aleckovic. "Abstract A029: SQ3370: CAPAC platform enables tumor-localized therapy and minimizes systemic toxicities." Clinical Cancer Research 28, no. 18_Supplement (2022): A029. http://dx.doi.org/10.1158/1557-3265.sarcomas22-a029.

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Abstract Conventional chemotherapies lack specificity for tumor tissue, have a low therapeutic index, and induce systemic toxicities including cardiomyopathy. SQ3370 utilizes the Click Activated Protodrugs Against Cancer (CAPAC) platform to localize doxorubicin (Dox) to tumor tissue while minimizing systemic exposure. SQ3370 consists of an intratumoral injection of a biopolymer followed by 5 daily intravenous doses of an attenuated protodrug of Dox. The tumor-localized activation of Dox is enabled by mutually reactive click chemistry groups on the biopolymer and protodrug, and is therefore agn

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Srinivasan, Sangeetha, Stefanie Wagner, George Coricor, Tri-Hung Nguyen, Jesse M. McFarland, and José M. Mejía Oneto. "Abstract 7213: Tumor targeted activation of an attenuated exatecan protodrug through Click Chemistry demonstrates efficacy in murine tumor studies." Cancer Research 84, no. 6_Supplement (2024): 7213. http://dx.doi.org/10.1158/1538-7445.am2024-7213.

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Abstract Shasqi is advancing the Click Activated Protodrugs Against Cancer (CAPAC®) platform based on click chemistry, a Nobel Prize winning technology. The platform is modular and comprises 1) an activator that target specific antigens, and 2) inert cancer drugs, protodrugs, which are selectively activated at tumors via click chemistry. The CAPAC technology separates the tumor targeting function from the payload and re-unites them at the tumor creating the flexibility to optimize activity while limiting toxicity during preclinical and clinical development. The modularity of the platform enabl

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Coricor, George, Jesse M. McFarland, Sangeetha Srinivasan, Stefanie Wagner, Tri-Hung Nguyen, and Jose M. Mejia Oneto. "Abstract 2056: Click chemistry enabled selective activation of highly cytotoxic MMAE payload at tumors using TROP2 targeting agent." Cancer Research 84, no. 6_Supplement (2024): 2056. http://dx.doi.org/10.1158/1538-7445.am2024-2056.

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Abstract Shasqi is advancing the Click Activated Protodrugs Against Cancer (CAPAC®) platform based on click chemistry, a Nobel Prize winning technology. The platform is modular and comprises 1) an activator that target specific antigens, and 2) inert cancer drugs, protodrugs, which are selectively activated at tumors via click chemistry. The CAPAC technology separates the tumor targeting function from the payload and reunite them at the tumor creating the flexibility to optimize activity while limiting toxicity during preclinical and clinical development. The modularity of the platform enables

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Aleckovic, Masa, Sangeetha Srinivasan, John Lee, et al. "Abstract 3261: SQ3370, a doxorubicin-based click chemistry therapeutic, promotes a shift from an immunosuppressive towards a T-cell permissive tumor microenvironment in patients." Cancer Research 83, no. 7_Supplement (2023): 3261. http://dx.doi.org/10.1158/1538-7445.am2023-3261.

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Abstract Click chemistry encompasses chemical reactions that are highly efficient, rapid, and proceed in complex environments. The 2022 Nobel Prize in Chemistry was awarded to Sharpless, Meldal, and Bertozzi in recognition of the transformative effect click chemistry has had in research and drug development. Shasqi is pioneering the use of click chemistry in humans with the Click Activated Protodrugs Against Cancer (CAPAC™) platform, which enables localization of an activator to tumors and conversion of attenuated protodrugs to active drugs though click chemistry reactions. Shasqi’s lead candi

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Reddy, Sangeetha, Meredith Carter, Isaac Chan, et al. "Abstract OT2-17-01: Phase 1 trial of anthracycline chemotherapy in combination with CD40 agonist and Flt3 ligand in metastatic triple-negative breast cancer." Cancer Research 83, no. 5_Supplement (2023): OT2–17–01—OT2–17–01. http://dx.doi.org/10.1158/1538-7445.sabcs22-ot2-17-01.

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Abstract Background: Only a subset of patients with metastatic triple-negative breast cancers (TNBC) demonstrate response to FDA approved PD-1 immune checkpoint blockade (ICB), and few have durable responses. Data suggests that breast cancers have defects in antigen presentation and that antigen presenting cells especially the DC1 subtype of dendritic cells (DCs) are required for response to ICB. CD40 agonists activate antigen presenting cells including DCs and B cells and also repolarize macrophages to an anti-tumor phenotype. Flt3 ligand is a growth factor that increases differentiation and

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Prabhakaran, Sangeetha, Vernon S. Pankratz, Christopher F. McNicoll, Jacklyn M. Nemunaitis, Nadja Falk, and Jain Zhou. "Abstract 6492: Body mass index characterization of patients undergoing neoadjuvant chemotherapy for breast cancer: Correlation with survival." Cancer Research 83, no. 7_Supplement (2023): 6492. http://dx.doi.org/10.1158/1538-7445.am2023-6492.

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Abstract Background: The significance of body mass index (BMI) on treatment outcomes of neoadjuvant chemotherapy for breast cancer and impact on overall survival is not well understood. We reviewed our single institution data on BMI of patients who underwent curative intent neoadjuvant chemotherapy for breast cancer. Methods: An IRB-approved retrospective review identified demographics (including BMI), disease presentation, response to treatment, and outcomes. ER and PR status were categorized as low positive (1-9%), positive (≥ 10%) and negative. Treatment response was noted as percent residu

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Coricor, George, Jesse M. McFarland, Masa Aleckovic, et al. "Abstract 4934: CAPAC: a modular platform that can improve the safety and efficacy of existing cancer therapies." Cancer Research 83, no. 7_Supplement (2023): 4934. http://dx.doi.org/10.1158/1538-7445.am2023-4934.

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Abstract Click chemistry is a Nobel Prize winning technology that has been widely used in research across the life sciences. Shasqi’s Click Activated Protodrugs Against Cancer (CAPACTM) platform is pioneering the therapeutic application of click chemistry reactions in humans. The 1st gen CAPAC technology enables activation of potent anti-cancer agents at the tumor site while reducing systemic exposure and is comprised of a tetrazine-modified biopolymer (tumor targeting agent) injected intratumorally and a systemically administered trans-cyclooctene-modified payload, named a protodrug. Our lead

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Coricor, George, Masa Aleckovic, Sangeetha Srinivasan, et al. "Abstract 342: First-in-class click chemistry-based pre-targeting of CEACAM5 tumor antigen selectively activates an MMAE payload at tumors." Cancer Research 85, no. 8_Supplement_1 (2025): 342. https://doi.org/10.1158/1538-7445.am2025-342.

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Abstract Targeted delivery technologies (ADC, TRT, etc.) are commonly dose-limited by off-target toxicities. Less than 1% of the dose is delivered to the tumor while the remainder follows the normal catabolic elimination route of the antigen-binder resulting in significant normal tissue exposure and toxicity. A pre-targeting approach such as Shasqi’s Click Activated Protodrugs Against Cancer (CAPAC®) technology, that separates the antigen-binder from the payload and reunites them only at the antigen is needed to overcome this limitation. CAPAC utilizes in-vivo click chemistry to selectively an

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Biechele, Travis L., Masa Aleckovic, Stefanie Wagner, et al. "Abstract 1793: Pre-targeting with in vivo click chemistry enables preferential drug exposure in tumors versus normal tissues." Cancer Research 85, no. 8_Supplement_1 (2025): 1793. https://doi.org/10.1158/1538-7445.am2025-1793.

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Abstract Off-target toxicity has long been a dose-limiting factor for antibody-drug conjugates (ADCs) and targeted radiopharmaceutical therapies (TRT). This fundamental limitation primarily arises due to the catabolic elimination process of both therapeutic modalities which exposes healthy tissues to cytotoxic agents. Pre-targeting offers a transformative solution to overcome these challenges as it separates the tumor-targeting and payload-delivery steps, thereby minimizing systemic exposure and maximizing on-target effects. Leveraging this concept, we present Click Activated Protodrugs Agains

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Najib, Ahmad, Virsa Handayani, and Muhammad Rizki Jaelani. "EVALUATION OF THE FREE RADICAL SCAVENGING OF TECTOQUINONE COMPOUND ISOLATED FROM SYZYGIUM OBLANCEOLATUM (C.B.ROB.) MERR." Universal Journal of Pharmaceutical Research, November 15, 2023. http://dx.doi.org/10.22270/ujpr.v8i5.1003.

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Aim and objective: In this study, the free radical scavenging of tectoquinone compound isolated from leaf of Syzygium oblanceolatum (C.B. Rob.) Merr was investigated by assessing their capacity to scavenge free radicals using the DPPH (2, 2-diphenyl-1-picrylhydrazyl) assay. Methods: The quantitative assessment of antioxidant activity was conducted using a UV-Vis spectrophotometric approach, with measurements taken at a wavelength of 516 nm. Results: The IC50 value, representing the concentration required to inhibit 50% of the DPPH radicals, was determined to be 66.362 μg/mL, indicating a moder

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"Retraction: Early Detection of Seizure Using Electrical Brain Activity (J. Phys.: Conf. Ser. 2325 012018)." Journal of Physics: Conference Series 2325, no. 1 (2022): 012059. http://dx.doi.org/10.1088/1742-6596/2325/1/012059.

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This article has been retracted by IOP Publishing following an allegation that this article may contain Tortured Phrases and verbatim replication of numerous sections of other published work [1]. IOP Publishing has investigated in line with the COPE guidelines and have found the article contains unconventional terms which has no significant relevance to the text and agree this article should be retracted [2]. The authors neither agree nor disagree to this retraction. [1] https://pubpeer.com/publications/8883135E8C79F503FF50E08E29A327 [2] V Sangeetha et al 2022 J. Phys.: Conf. Ser. 2325 012018

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Ozgun, Gamze, Husniye Kayalar, Fatih Alaylı, İbrahim Cavus, Fatih Dönmez, and Ahmet Ozbilgin. "ANTILEISHMANIAL EFFICACY OF HERACLEUM PERSICUM DESF. EX. FISCH. EXTRACTS AGAINST LEISHMANIA TROPICA PROMASTIGOTES." Universal Journal of Pharmaceutical Research, September 14, 2024. http://dx.doi.org/10.22270/ujpr.v9i4.1154.

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Background: Heracleum persicum known as “suhotu” is widely distributed in Adana, Hakkari Van and used in the production of famous Van herb cheese. The antioxidant, antiinflammatory, antidiabetic, antiepileptic, hepatoprotective, and antifungal properties were previously investigated on H. persicum extracts. Objectives: The purpose of the present study was to comparatively evaluate the in vitro antiLeishmanial potential of H. persicum extracts prepared by solvents having different polarities. Methods: The extracts of aerial parts of H. persicum were obtained by maceration, and in vitro antiLeis

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