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Academic literature on the topic 'SAP( Severe Acute Pancreatitis) APACHE II Ranson score BISAP Score'
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Journal articles on the topic "SAP( Severe Acute Pancreatitis) APACHE II Ranson score BISAP Score"
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Dr. Girish S.P. and Dr. Sainani Rahul Raju. "Clinical Prediction of outcomes in Acute Pancreatitis with Various Prognostic Indicators and Modified CTSI." IAR Journal of Medicine and Surgery Research 1, no. 3 (2020): 41–45. http://dx.doi.org/10.47310/iarjmsr.2020.v01i03.10.
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Introduction: Acute pancreatitis is the most common cause of patients presenting to the emergency department with pain abdomen. It is an inflammatory process of the pancreas that can range from mild inflammation to severe extensive pancreatic necrosis and multi-organ failure with mortality rates of 20% to 30%. Diagnosis can be difficult, because there is no pathognomic clinical presentation and no diagnostic gold standard. Material and Methods: It was a prospective cross-sectional descriptive study conducted in the Department of Gastroenterology at Sapthagiri Institute of Medical Sciences and Research Center from December 2019 – August 2020 among 100 patients. Results: The total patients studied in this study were 100, which comprises of 93 males and 7 females. Among the male population the maximum age group is 41-50. Next comes the 31-40 which includes 30 patients. Among the female population the maximum age group is 41-50 which includes about 4 patients. In our study distribution of the SAP within and above the cut off value of the different prognostic scores. 11 patients with SAP had RANSONs score < 3 and 10 with SAP had RANSON score ≥ 3. 11 patients with SAP had APACHE II score of ≥8 whereas 10 had APACHE II score < 8. But only 8 patients with SAP had BISAP score < 3 and 13 SAP patients had BISAP score ≥ 3. MCTSI score in 11 SAP was < 4 and 10 patients with MCTSI had ≥ 4. Conclusion: BISAP score is simple and it is the better scoring system in predicting the prognosis when compared to other scores & MCTSI. BISAP score has many advantages when compared to other scoring systems.
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Khanna, Ajay K., Susanta Meher, Shashi Prakash, et al. "Comparison of Ranson, Glasgow, MOSS, SIRS, BISAP, APACHE-II, CTSI Scores, IL-6, CRP, and Procalcitonin in Predicting Severity, Organ Failure, Pancreatic Necrosis, and Mortality in Acute Pancreatitis." HPB Surgery 2013 (September 24, 2013): 1–10. http://dx.doi.org/10.1155/2013/367581.
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Background. Multifactorial scorings, radiological scores, and biochemical markers may help in early prediction of severity, pancreatic necrosis, and mortality in patients with acute pancreatitis (AP). Methods. BISAP, APACHE-II, MOSS, and SIRS scores were calculated using data within 24 hrs of admission, whereas Ranson and Glasgow scores after 48 hrs of admission; CTSI was calculated on day 4 whereas IL-6 and CRP values at end of study. Predictive accuracy of scoring systems, sensitivity, specificity, and positive and negative predictive values of various markers in prediction of severe acute pancreatitis, organ failure, pancreatic necrosis, admission to intensive care units and mortality were calculated. Results. Of 72 patients, 31 patients had organ failure and local complication classified as severe acute pancreatitis, 17 had pancreatic necrosis, and 9 died (12.5%). Area under curves for Ranson, Glasgow, MOSS, SIRS, APACHE-II, BISAP, CTSI, IL-6, and CRP in predicting SAP were 0.85, 0.75, 0.73, 0.73, 0.88, 0.80, 0.90, and 0.91, respectively, for pancreatic necrosis 0.70, 0.64, 0.61, 0.61, 0.68, 0.61, 0.75, 0.86, and 0.90, respectively, and for mortality 0.84, 0.83, 0.77, 0.76, 0.86, 0.83, 0.57, 0.80, and 0.75, respectively. Conclusion. CRP and IL-6 have shown a promising result in early detection of severity and pancreatic necrosis whereas APACHE-II and Ranson score in predicting AP related mortality in this study.
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Xu, Ruoxin, Ju Gong, Wei Chen, Yakang Jin, and Jian Huang. "Soluble B7-H5 Is a Novel Diagnostic, Severity, and Prognosis Marker in Acute Pancreatitis." BioMed Research International 2021 (October 8, 2021): 1–8. http://dx.doi.org/10.1155/2021/1223850.
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As an important ligand in T lymphocyte costimulatory pathways, B7-H5 is involved deeply in the immune response in various diseases. However, its clinical usefulness as an early indicator in acute pancreatitis (AP) remains unclear. In this study, the levels of sB7-H5 and cytokines in plasma samples of 75 AP patients, 20 abdominal pain patients without AP, and 20 healthy volunteers were determined. Then, the correlation of sB7-H5 and clinical features, cytokines, the Ranson score, APACHE II score, Marshall score, and BISAP score was analysed, and the value of sB7-H5 for diagnostic, severity, and prognosis of AP was evaluated. We found that the levels of sB7-H5 were specifically upregulated in AP patients. Receiver operating characteristic (ROC) analysis revealed that sB7-H5 can identify AP patients from healthy or abdominal pain patients with 78.9% or 86.4% sensitivity and 93.3% or 90.0% specificity. Further analysis showed that the levels of sB7-H5 were significantly correlated with WBC ( p = 0.004 ), GLU ( p = 0.008 ), LDH ( p < 0.001 ), Ca2+ ( p = 0.006 ), AST ( p = 0.009 ), PLT ( p = 0.041 ), IL-6 ( p < 0.001 ), IL-10 ( p < 0.001 ), and TNF-α ( p < 0.001 ). And levels of sB7-H5 were gradually increased among patients with mildly acute pancreatitis (MAP), moderately severe acute pancreatitis (MSAP), and severe acute pancreatitis (SAP). It can distinguish the severity of AP with good sensitivity and specificity. Moreover, when dividing the patients into two groups according to the median level of sB7-H5, the local complication and length of stay of low levels of the sB7-H5 group were significantly less than those in high levels of the sB7-H5 group. And the levels of sB7-H5 in AP patients were significantly correlated with the Ranson score ( p < 0.001 ), APACHE II score ( p < 0.001 ), Marshall score ( p < 0.001 ), and BISAP score ( p < 0.001 ). The AUCs of assessing local complications of sB7-H5 at day 1 and day 3 were 0.704 ( p = 0.0024 ) and 0.727 ( p = 0.0373 ). These results showed the potential value of sB7-H5 as a diagnostic, severity, and prognosis marker of AP.
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a, Akshay, Basavaraj R. Patil, and Vinod V. Sangavi. "A STUDY OF SERUM CALCIUM AND SERUM ALBUMIN LEVELS IN PREDICTING SEVERITY OF ACUTE PANCREATITIS." International Journal of Advanced Research 11, no. 01 (2023): 1598–608. http://dx.doi.org/10.21474/ijar01/16183.
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Background:Acute Pancreatitis (AP) is an acute inflammatory process of the pancreas that affects other regional tissues and more distant organ system through the systemic inflammatory response , resulting in organ dysfunction and death. Only Minority patients will develop a severe disease , while most patients suffer from a mild ,self limiting inflammatory process.About 10 to 20% of patients will progress to Severe Acute Pancreatitis (SAP) with a mortality rate of 6 to 10 %. Serum calcium and serum albumin obtained within the first 24 hours of hospital admission are useful predictors of severity in Acute Pancreatitis . With an adequate interpretation of their cut-off points, they are valuable for identifying the patients that require intensive care support, even in primary and secondary care centers.So easily availaibilty of these laboratory investigation can be used for early assessment and treatment of severe Acute Pancreatitis(SAP) and therefore helps in reducing mortality due to Acute pancreatitis. we also compared and correlated other scoring system in predicting the severity of acute pancreatitis. Materials and Methods: We conducted a prospective observational study of serum calcium and serum albumin levels in predicting severity of acute pancreatitis. Data was collected from 100 inpatients over 18 months admitted to in-patient in Department of general Medicine,Basaveshwara Teaching and General Hospital attached to M.R Medical College, Kalaburgi .Data was analyzed using SPSS software version 26. Results: Total of 100 patients with 87 males and 13 females were enrolled. Among the 100 patients 31 patients developed Severe Acute Pancreatitis (SAP) marked by evidence of end organ failure, local complications like psuedocyst, and /or prolonged ICU stay of more than 7 days and 9 patients died. Among the individual parameters Serum Albumin, Serum calcium, Corrected serum calcium including TC (Total cell count), Serum Urea, ,Serum creatinine , Pao2 ,Serum LDH showed a significant association with severity of acute pancreatitis . APACHE II systems had a sensitivity of 71.10% and specificity of 96.67 % in predicting severity.Sensitivity and specificity of Ransons score was 77.42% and 96.56% respectively. BISAP score had a low sensitivity of 61.67% and high specificity 98.33% . Conclusion:APACHE II score and Ransons score are the best scoring systems in predicting the severity of acute pancreatitis. Parameters like Hypoalbuminemia, Hypocalcemia including Hypoxia,uremia, Acute renal failure, leukocytosis, and increase in serum LDH levels weresignificantly associated with Severe Acute Pancreatitis(SAP).
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Mahajan, Ojas, Satish Mahajan, Sourya Acharya, et al. "A comparative evaluation of different scores in predicting severity and outcome in acute pancreatitis." F1000Research 12 (July 13, 2023): 824. http://dx.doi.org/10.12688/f1000research.133278.1.
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Background: Acute pancreatitis (AP) is an inflammatory condition usually caused by alcohol or gallstones. Our goal was to prospectively compare the diagnostic efficacy of the Acute Physiology & Chronic Health Evaluation (APACHE) II, the Bedside Index of Severity in Acute Pancreatitis (BISAP), the Ranson's score & the Modified Glasgow Score (MGS) in determining the severity & outcome of Acute pancreatitis in a tertiary care facility in central India. Methods: Between December 2020 & December 2022, this prospective observational study was done in rural area of Wardha district. 110 subjects were included, and the diagnosis of acute pancreatitis was done using Atlanta criteria. APACHE II, MGS, Ranson score on admission, Ranson score 48 hours after admission & BISAP were used to evaluate each subject. The reciever operating curve was used to measure the specificity, sensitivity, NPV, PPV, diagnostic accuracy, area under the curve (AUC) & these scoring methods were then prospectively compared. Results: When a cut-off based on the literature was used, the APACHE II score could accurately diagnose severe cases of AP (n=110) in 69 patients, BISAP in 68 patients, MGS in 49, Ranson score on admission in 48 patients & after 48 hours in 48 patients. This study showed that Ranson score 48 hours after admission had a AUC (0.991), Ranson score at admission (AUC 0.989) & Modified Glasgow Scale (AUC 0.6486) had fair accuracy as compared to APACHE II (AUC 0.974) & BISAP (AUC 0.896) for determining the level of severity among AP patients based on ROC curves. Conclusion: To predict the severity of AP, the Ranson score after 48 hours showed the highest NPV, PPV, sensitivity, specificity, and diagnostic accuracy of all the scoring methods tested. The BISAP score had the highest specificity, sensitivity, PPV& NPV for determining the outcome of AP.
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Dr., Velmurugan S., (Prof.) T.R. Khurana Dr., and (Prof.) Shibani Mehra Dr. "Evaluation of the severity of acute pancreatitis using BISAP, Ranson and APACHE II scores and comparing them with Modified Computed Tomography Severity Index score." International Multispeciality Journal of Health 7, no. 10 (2021): 07–13. https://doi.org/10.5281/zenodo.5624782.
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<strong>Abstract</strong><strong>—</strong> <strong>Aims and Objectives:</strong> Most of the studies published so far compare one or two out of the three clinical scores for assessing the severity of acute pancreatitis namely BISAP, Ranson and APACHE II scores with the Radiological Score of Modified Computed Tomography Severity Index. There is a paucity of studies that compare all three Clinical Scores with the Radiological Score of Modified Computed Tomography Severity Index. The aim of this study is to compare all three clinical scores with the radiological score mentioned above. <strong>Materials and Methods:</strong> This is a cross sectional study which was conducted in the Department of Medicine and Department of Radiology, ABVIMS and Dr. Ram Manohar Lohia Hospital, New Delhi. A total of 40 patients were studied from November 2018 to March 2020. Admitted patients who fit into the New Diagnostic Criteria of the Revised Atlanta Classification for acute pancreatitis were taken into the study after getting the informed consent signed. CECT abdomen was done during the hospital stay and modified CTSI score was calculated. Patients with BISAP score ≥ 3, Ranson score ≥ 3, APACHE II score ≥ 8 and modified CTSI ≥ 4 (4-6: moderately severe, 8-10: severe; Note that in modified CTSI score, the final scores are always in even number) were classified as severe acute pancreatitis. <strong>Results:</strong> The results of our study showed that the Modified CTSI score has the highest accuracy among the four scores in predicting severity of acute pancreatitis (AUC 0.969, P value <0.0001) which is statistically significant. Among the bedside scores namely APACHE II, Ranson and BISAP scores, the AUC was high in APACHE II score (AUC 0.750, P value 0.001) in comparison with Ranson score (AUC 0.688, P value <0.0001) and BISAP score (AUC 0.656, P value 0.0002). Click here to download full Paper
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Theerthegowda, Akhila Nallur, Pavithra Umashankar, and Nagashri Suresh Iyer. "A Comparative Study between Bedside Index for Severity in Acute Pancreatitis (BISAP) and Acute Physiology and Chronic Health Evaluation (APACHE-II) Scoring System in Assessing the Severity of Acute Pancreatitis at Bangalore Medical College and Research Institute, Bangalore, India." Journal of Evidence Based Medicine and Healthcare 8, no. 36 (2021): 3269–75. http://dx.doi.org/10.18410/jebmh/2021/594.
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BACKGROUND Acute pancreatitis (AP) is an inflammatory disease of the pancreas, that results from intrapancreatic activation, release, and digestion of the organ by its own enzymes. The diagnosis of acute pancreatitis can be made when a patient presents with threefold elevated serum levels of amylase or lipase, abdominal pain and vomiting. In this study, we wanted to assess the severity of acute pancreatitis by using BISAP (Bedside index for severity in acute pancreatitis) and APACHE-II (Acute physiology and chronic health evaluation) scoring systems and compare the accuracy of BISAP scores with APACHE-II scores. METHODS A prospective study including 201 patients was conducted from April 2018 to March 2020 in Victoria Hospital, affiliated to BMCRI. RESULTS Among 201 AP patients, 129 were found to have mild acute pancreatitis (MAP), 72 were of severe acute pancreatitis (SAP), 192 survival cases, and 9 death cases. The larger the rating score, the higher the proportion of severe pancreatitis and mortality risk. Two kinds of scoring criteria; BISAP score points and Apache II score points compared in patients with MAP and SAP, In Apache II score to predict severity of organ failure, the sensitivity, specificity, positive predictive value, negative predictive value was 84.72 %, 93.02 %, 87.14 %, 91.60 % and area under the curve was 0.958 (P < 0.0001). In BISAP, the sensitivity, specificity, positive predictive value, negative predictive value was 90.28 %, 80.62 %, 72.22 %, 93.69 % and area under the curve was 0.917 (P < 0.0001). CONCLUSIONS Ability of APACHE II score prediction of AP in severity of organ failure and mortality are stronger than BISAP score, But APACHE II scoring system indicators were cumbersome, complicated assessment. BISAP scoring system is simple, economical, rapid and reliable, and it can effectively predict the severity and mortality of acute pancreatitis, and can be used as a preliminary screening method in accurate risk stratification and initiation of management accordingly at community health care, secondary health care and tertiary health care Hospitals. KEYWORDS Pancreatitis, Severity, Prediction, APACHE II and BISAP
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Sehgal, Rishabh, Inder Pal Singh та Jyotisterna Mittal. "Clinical Profile and Outcome of Patients with Severe Acute Pancreatitis". Asian Journal of Medical Research 9, № 3 (2020): 8–11. http://dx.doi.org/10.47009/ajmr.2020.9.3.me2.
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Background: Acute pancreatitis (AP) is an acute inflammatory condition of the pancreas leading to pancreatic autodigestion. The present study was conducted to study the clinical profile and outcome of patients with severe acute pancreatitis. Subjects & Methods: The study was conducted on 40 patients of acute pancreatitis. Clinical profile including history, examination findings, etiology of pancreatitis, clinical severity (according to Modified Marshall Score, BISAP score, APACHE II, HAPS score, SOFA score) was recorded. Results: Severe Acute Pancreatitis (SAP) among patients. Majority of the patients i.e. 22 (55%) had alcohol consumption as etiological factor causing SAP followed by biliary 10 (25%) & idiopathic 5 (12.5%). Hypertriglyceridemia and drug-induced (herbal medication) pancreatitis was present in 1 (2.5%) patient each. Out of all 1 (2.5%), patients had a history of both alcohol consumption and the presence of gallstone as an etiological factor. 22 patients (55%) out of 40 patients only conservative management was used while 18(45%) patients underwent USG guided percutaneous drainage was done. Out of these 18 patients, 3(7.5%) patients required Laparoscopic Necrosectomy & 2(5%) patients required open necrosectomy in addition to ultrasound-guided PCD. Patients who improved had a mean BISAP SCORE of 2.15 0.54, Modified Marshall score of 3.65 1.44, APACHE II score of 9.77 4.45, SOFA score 5.54 2.49, RANSON’s score 3.85 1.80 and HAP score of 0.65 0.63. Conclusion: Most common etiology of severe acute pancreatitis is alcohol followed by biliary etiology. Out of severity scores (BISAP, APACHE-II, SOFA, HAPS), only BISAP score ≥3 is predictive of poor outcome in patients with severe acute pancreatitis.
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Yang, Lixin, Jing Liu, Yun Xing, et al. "Comparison of BISAP, Ranson, MCTSI, and APACHE II in Predicting Severity and Prognoses of Hyperlipidemic Acute Pancreatitis in Chinese Patients." Gastroenterology Research and Practice 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/1834256.
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In recent years, with the developing of living standard, hyperlipidemia becomes the second major reason of acute pancreatitis. It is important to predict the severity and prognosis at early stage of hyperlipidemic acute pancreatitis (HLAP). We compared the BISAP, Ranson, MCTSI, and APACHE II scoring system in predicting MSAP and SAP, local complications, and mortality of HLAP. A total of 326 diagnosed hyperlipidemic acute pancreatitis patients from August 2006 to July 2015 were studied retrospectively. Our result showed that all four scoring systems can be used to predict the severity, local complications, and mortality of HLAP. Ranson did not have significant advantage in predicting severity and prognosis of HLAP compared to other three scoring systems. APACHE II was the best in predicting severity of HLAP, but it had shortcoming in predicting local complications. MCTSI had outstanding performance in predicting local complications, but it was poor in predicting severity and mortality. BISAP score had high accuracy in assessment of severity, local complications, and mortality of HLAP, but the accuracy still needs to be improved in the future.
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Chen, Lifen, Guomin Lu, Qunyan Zhou, and Qiang Zhan. "Evaluation of the BISAP Score in Predicting Severity and Prognoses of Acute Pancreatitis in Chinese Patients." International Surgery 98, no. 1 (2013): 6–12. http://dx.doi.org/10.9738/0020-8868-98.1.6.
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Abstract The present study was to evaluate the accuracy of bedside index for severity in acute pancreatitis (BISAP) in predicting the severity and prognoses of acute pancreatitis (AP) in Chinese patients. Clinical data for 497 patients with AP were analyzed retrospectively to compare BISAP with acute physiology and chronic health evaluation II, Ranson, and computed tomography severity index scores in predicting the severity of AP and the occurrence of pancreatic necrosis, mortality, and organ failure in patients with severe AP (SAP) using the area under the receiver-operating characteristic curve. Of the 497 patients, 396 had mild AP and 101 had SAP. There were significant correlations between the scores of any two systems. BISAP performed similarly to other scoring systems in predicting SAP, as well as pancreatic necrosis, mortality, and organ failure in SAP patients, in terms of the area under the receiver-operating characteristic curve. BISAP score is valuable in predicting the severity of AP and prognoses of SAP in Chinese patients.