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Journal articles on the topic 'SAR (Structure activity relationship)'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Ma, Anqi, Wenyu Yu, Yan Xiong, Kyle V. Butler, Peter J. Brown, and Jian Jin. "Structure–activity relationship studies of SETD8 inhibitors." MedChemComm 5, no. 12 (2014): 1892–98. http://dx.doi.org/10.1039/c4md00317a.

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2

Wawer, Mathias J., David E. Jaramillo, Vlado Dančík, et al. "Automated Structure–Activity Relationship Mining." Journal of Biomolecular Screening 19, no. 5 (2014): 738–48. http://dx.doi.org/10.1177/1087057114530783.

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Understanding the structure–activity relationships (SARs) of small molecules is important for developing probes and novel therapeutic agents in chemical biology and drug discovery. Increasingly, multiplexed small-molecule profiling assays allow simultaneous measurement of many biological response parameters for the same compound (e.g., expression levels for many genes or binding constants against many proteins). Although such methods promise to capture SARs with high granularity, few computational methods are available to support SAR analyses of high-dimensional compound activity profiles. Man

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3

Devillers, J., A. Doucet-Panaye, and J. P. Doucet. "Structure–activity relationship (SAR) modelling of mosquito larvicides." SAR and QSAR in Environmental Research 26, no. 4 (2015): 263–78. http://dx.doi.org/10.1080/1062936x.2015.1026571.

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4

Wu, Tao, Osafo Raymond Kwaku, Hai-Zhou Li, Chong-Ren Yang, Long-Jiao Ge, and Min Xu. "Sense Ginsenosides From Ginsengs: Structure-Activity Relationship in Autophagy." Natural Product Communications 14, no. 6 (2019): 1934578X1985822. http://dx.doi.org/10.1177/1934578x19858223.

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The term ginseng refers to the dried roots of several plants belonging to the genus Panax of the Araliaceae family. The 3 major commercial ginsengs are Panax notoginseng (Burk.) F.H. Chen (Notoginseng), P. ginseng C.A. Meyer (Ginseng), and P. quinquefolius L. (American ginseng), which have been used as herbal medicines. Over 18,000 papers on ginsengs have been published on the basis of their structural diversity and biological activities. Many reviews have summarized the phytochemistry, pharmacology, and clinical use of ginsengs, but the structure-activity relationship (SAR) of ginsenosides fr

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5

T., Shubhavathi1 Raghu Ram Achar2 B.S. Priya1*. "3-BENZAZEPINONE DERIVATIVES: ANTIOXIDANT ACTIVITY AND ITS STRUCTURE ACTIVITY RELATIONSHIP (SAR) STUDIES." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 01 (2017): 7415–19. https://doi.org/10.5281/zenodo.1006933.

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A series of 3-benzazepinone (3-BZ) derivatives were tested for their in vitro antioxidant efficacy by DPPH and LPO assays and compared with standard Butylated Hydroxyl Anisole (BHA). The derivatives containing electron donating groups viz., OH, OCH3 were found to be good antioxidants compared to BHA. While, the compounds containing electron withdrawing moiety viz., NO2, Cl, Br, and F were found to be less active compared to standard BHA. The structure activity relationship studies suggest that the electron donating moieties majorly contribute to the anti-oxidant property of the potent compound

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6

Nyembe, Priscilla L., Thandokuhle Ntombela, and Maya M. Makatini. "Review: Structure-Activity Relationship of Antimicrobial Peptoids." Pharmaceutics 15, no. 5 (2023): 1506. http://dx.doi.org/10.3390/pharmaceutics15051506.

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Due to their broad-spectrum activity against Gram-negative and Gram-positive bacteria, natural antimicrobial peptides (AMPs) and their synthetic analogs have emerged as prospective therapies for treating illnesses brought on by multi-drug resistant pathogens. To overcome the limitations of AMPs, such as protease degradation, oligo-N-substituted glycines (peptoids) are a promising alternative. Despite having the same backbone atom sequence as natural peptides, peptoid structures are more stable because, unlike AMP, their functional side chains are attached to the backbone nitrogen (N)-atom rath

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7

Gao, Yong-Guang, Xiao Lin, Kai Dang, et al. "Structure–activity relationship of novel low-generation dendrimers for gene delivery." Organic & Biomolecular Chemistry 16, no. 42 (2018): 7833–42. http://dx.doi.org/10.1039/c8ob01767k.

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8

Liu, Xiaofan, Yanping Wang, Richard I. Duclos, and George A. O’Doherty. "Stereochemical Structure Activity Relationship Studies (S-SAR) of Tetrahydrolipstatin." ACS Medicinal Chemistry Letters 9, no. 3 (2018): 274–78. http://dx.doi.org/10.1021/acsmedchemlett.8b00050.

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9

Mukesh, Bugalia, B. Puranik Sangamesh, Saraswat Rohit, Jhajharia Mahesh, and Sharma Prashant. "Synthesis of Thiazoles and 1,3,4-Thiadiazoles Bearing Spectral Studies, Biological Evaluation and Structure Activity relationship." International Journal of Engineering Research & Science 6, no. 7 (2020): 21–33. https://doi.org/10.5281/zenodo.4095165.

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<strong>Abstract</strong><strong>—</strong> A novel series of thiazole based-1,3,4-thiadiazoles were designed and prepared via the reaction of the 2-(4-methyl-2-phenylthiazole-5-carbonyl)-N-phenylhydrazinecarbothioamide with the appropriate hydrazonoyl chlorides. The structures of the newly synthesized compounds were established based on spectroscopic evidences and their alternative syntheses. Thirteen new 1,3,4-thiadiazoles have been evaluated for their anticancer activity against liver carcinoma cell line (HepG2). Also, their structure activity relationship (SAR) was studied. The 1,3,4

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10

Schiffrer, Eva Shannon, Izidor Sosič, Andrej Šterman, et al. "A focused structure–activity relationship study of psoralen-based immunoproteasome inhibitors." MedChemComm 10, no. 11 (2019): 1958–65. http://dx.doi.org/10.1039/c9md00365g.

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11

Hasdenteufel, Frédéric, Samuel Luyasu, Jean-Marie Renaudin, Philippe Trechot, and Gisèle Kanny. "Anaphylactic Shock Associated with Cefuroxime Axetil: Structure—Activity Relationships." Annals of Pharmacotherapy 41, no. 6 (2007): 1069–72. http://dx.doi.org/10.1345/aph.1k050.

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OBJECTIVE: To present a predictive model of allergenicity based on a structure– activity relationship analysis of β-lactam antibiotics using appropriate skin testing procedures. CASE SUMMARY: A 39-year-old woman was diagnosed with anaphylactic shock a few minutes after taking a 500 mg tablet cefuroxime of axetil and was admitted to the emergency department with dizziness, facial angioedema, generalized skin rash, and inferior cardiac ischemia. Skin testing confirmed the involvement of cefuroxime as the cause of the anaphylactic reaction, and the reaction was defined as probable according to th

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12

Steinbach, Thomas, Samantha Gad-McDonald, Naomi Kruhlak, Mark Powley, and Nigel Greene. "(Q)SAR: A Tool for the Toxicologist." International Journal of Toxicology 34, no. 4 (2015): 352–54. http://dx.doi.org/10.1177/1091581815584914.

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A continuing education (CE) course at the 2014 American College of Toxicology annual meeting covered the topic of (Quantitative) Structure–Activity Relationships [(Q)SAR]. The (Q)SAR methodologies use predictive computer modeling based on predefined rules to describe the relationship between chemical structure and a chemical’s associated biological activity or statistical tools to find correlations between biologic activity and the molecular structure or properties of a compound. The (Q)SAR has applications in risk assessment, drug discovery, and regulatory decision making. Pressure within ind

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13

Bagum, Halima, Mark G Moloney, and Md Rabiul Islam. "A qualitative structure activity relationship (SAR) study of selected pyroglutamates." Journal of Bangladesh Academy of Sciences 48, no. 2 (2024): 165–70. https://doi.org/10.3329/jbas.v48i2.70546.

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A library of Pyroglutamate derivatives (Fig. 1-4: 8a-8f, 9a-9d, 10a-10e, 11a-11f, 12a-12c, 13 and 14) have been analysed qualitatively to investigate their Structure Activity Relationships (SAR). Antibacterial screening data used for this work was against the selected multidrug-resistant pathogens including both Gram-negative and Gram-positive bacteria. Among the synthesized compounds, pyroglutamates 8e and 11d are more potent as antibacterial agent. J. Bangladesh Acad. Sci. 48(2); 165-170: December 2024

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GUO, QINYUAN, SHENGLIN LUO, QINGRONG QI, and CHUNMENG SHI. "PRELIMINARY STRUCTURE–ACTIVITY RELATIONSHIP STUDY OF HEPTAMETHINE INDOCYANINE DYES FOR TUMOR-TARGETED IMAGING." Journal of Innovative Optical Health Sciences 06, no. 01 (2013): 1350003. http://dx.doi.org/10.1142/s179354581350003x.

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Our research has identified a couple of near-infrared (NIR) heptamethine indocyanine dyes exhibiting preferential tumor accumulation property for in vivo imaging. On the basis of our foregoing work, we describe here a preliminary structure–activity relationship (SAR) study of 11 related heptamethine indocyanine dyes and several essential requirements of these structures for in vivo tumor-targeted imaging.

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15

Luhata, Lokadi Pierre, and Wembi Gaston Luhata. "Tiliroside: Biosynthesis, Bioactivity and Structure activity relationship (SAR)- A review." Journal of Phytopharmacology 6, no. 6 (2017): 343–48. http://dx.doi.org/10.31254/phyto.2017.6607.

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Tilirosides (TLD) are glycosidic flavonoids (GFD) from originating in plants that exhibit a range of bioactivities of great interest for healthcare: antioxidant, anti-microbial, antifungal, anti-diabetic and antihyperlipedemic, antiviral and cytotoxic, anti–inflammatory, anti-rheumatism, inhibition of neuroinflammation and acute inflammation and hepatoprotective activities. TLD are biosynthesized in plants in three main steps. First, the synthesis of the aglycone (a flavonoid) occurs, which follows the shikimate pathway with cinnamoylCoA as a starter unit. Second, there is the glucosylation of

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16

Vendrame, R., V. R. Coluci, R. S. Braga, and D. S. Galvão. "Structure–activity relationship (SAR) studies of the tripos benchmark steroids." Journal of Molecular Structure: THEOCHEM 619, no. 1-3 (2002): 195–205. http://dx.doi.org/10.1016/s0166-1280(02)00578-x.

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17

Martinez-Gonzalez, A. I., Á. G. Díaz-Sánchez, L. A. de la Rosa, I. Bustos-Jaimes та E. Alvarez-Parrilla. "Inhibition of α-amylase by flavonoids: Structure activity relationship (SAR)". Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 206 (січень 2019): 437–47. http://dx.doi.org/10.1016/j.saa.2018.08.057.

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18

Holder, Jerry Ryan, and Carrie Haskell-Luevano. "Melanocortin ligands: 30 years of structure-activity relationship (SAR) studies." Medicinal Research Reviews 24, no. 3 (2004): 325–56. http://dx.doi.org/10.1002/med.10064.

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19

Gore, Vijay K., Vu V. Ma, Ruoyuan Yin, et al. "Structure–activity relationship (SAR) investigations of tetrahydroquinolines as BKCa agonists." Bioorganic & Medicinal Chemistry Letters 20, no. 12 (2010): 3573–78. http://dx.doi.org/10.1016/j.bmcl.2010.04.125.

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20

Romano, Giulia, and Marco Conti. "Structure-Activity Relationship (SAR) Analysis of Newly Synthesized Antimicrobial Agents." International Journal of Emerging Trends in Chemistry (IJETC) 1, no. 2 (2025): 42–59. https://doi.org/10.64056/25as3e60.

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The increasing threat of antimicrobial resistance (AMR) necessitates the development of new antimicrobial agents with improved potency and safety. Although heterocyclic scaffolds have shown promise, limitations in efficacy and selectivity remain. In this study, we designed, synthesized, and characterized 24 novel antimicrobial compounds based on thiazole, quinoxaline, and ultrashort lipopeptide scaffolds using one-pot cyclization and solid-phase peptide synthesis. These compounds were evaluated against a panel of multidrug-resistant Gram-positive and Gram-negative bacteria, including methicill

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21

Okwute, Simon K., and Lester A. Mitscher. "Structure-Activity Relationship Among the Antibacterial Pterocarpans from African Erythrina Species: A Review." Tropical Journal of Phytochemistry and Pharmaceutical Sciences 3, no. 5 (2024): 303. https://doi.org/10.26538/tjpps/v3i5.2.

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The genus Erythrina, a folkloric medicinal plant found in many tropical regions of the world, has yielded many flavonoids, including isoflavonoids of diverse structures. Some African Erythrina species have been investigated, and many have been found to contain isoflavonoids belonging to the sub-class pterocarpans which have displayed structural variations and interesting antibacterial activities. In this review, the structures and antibacterial activities of 14 pterocarpans reported in the literature from 8 African Erythrina species have been collated and subjected to structure-activity relati

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22

Heib, Anna, Giuliana Niro, Stefanie C. Weck, Stefan Koppermann, and Christian Ducho. "Muraymycin Nucleoside Antibiotics: Structure-Activity Relationship for Variations in the Nucleoside Unit." Molecules 25, no. 1 (2019): 22. http://dx.doi.org/10.3390/molecules25010022.

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Muraymycins are a subclass of naturally occurring nucleoside antibiotics with promising antibacterial activity. They inhibit the bacterial enzyme translocase I (MraY), a clinically yet unexploited target mediating an essential intracellular step of bacterial peptidoglycan biosynthesis. Several structurally simplified muraymycin analogues have already been synthesized for structure–activity relationship (SAR) studies. We now report on novel derivatives with unprecedented variations in the nucleoside unit. For the synthesis of these new muraymycin analogues, we employed a bipartite approach faci

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23

Kurniawan, Ilham, and Hafizh Zahra. "Review: Gallotannins; Biosynthesis, Structure Activity Relationship, Anti-inflammatory and Antibacterial Activity." Current Biochemistry 8, no. 1 (2021): 1–16. http://dx.doi.org/10.29244/cb.8.1.1.

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Tannins are one of the main compounds in plants with potential health benefits. Gallotannin is one of the biologically active tannins groups produced by some medicinal plants. Gallotannins is a hydrolyzable tannin compound biosynthesized through gallic acid, shikimic acid, and pentagalloylglucose pathways. Gallotannins can be separated by cascade solvent extraction procedures, column chromatography, and preparative HPLC. This review focuses on the discussion of biosynthesis and structure-activity relationship of tannins as antibacterial and anti-inflammatory. The structure-activity relationshi

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24

Aini, Nur, Bambang Purwono, and Iqmal Tahir. "STRUCTURE – ANTIOXIDANT ACTIVITIES RELATIONSHIP ANALYSIS OF ISOEUGENOL, EUGENOL, VANILIN AND THEIR DERIVATIVES." Indonesian Journal of Chemistry 7, no. 1 (2010): 61–66. http://dx.doi.org/10.22146/ijc.21714.

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Structure Activity Relationship (SAR) technique between the theoretical parameters and antioxidant activities of isoeugenol, eugenol, vanillin and their derivatives as Mannich reaction products, have been analyzed. Antioxidant activities were examined by oxidation reaction of oleic acid at 60 °C with b-carotene methods, whereas theoretical parameters of the activities were determined by calculating Bonding Dissociation Enthalpy (BDE) and net charge of oxygen atom(-OH) using AM1 semi empiric methods. The result from both test showed in the following orders: BHT > Mannich product of isoeugeno

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25

Alves, Claúdio N., Luiz G. M. de Macedo, Káthia M. Honório, et al. "A Structure-Activity Relationship (SAR) Study of Neolignan Compounds with Anti-schistosomiasis Activity." Journal of the Brazilian Chemical Society 13, no. 3 (2002): 300–307. http://dx.doi.org/10.1590/s0103-50532002000300003.

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26

Zhao, Yu, Po-Yen Liu, Kan-Yen Hsieh, et al. "Design, synthesis and structure–activity relationships of (±)-isochaihulactone derivatives." MedChemComm 8, no. 11 (2017): 2040–49. http://dx.doi.org/10.1039/c7md00310b.

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27

Rashid, Haroon ur, Marco Antonio Utrera Martines, Adriana Pereira Duarte, et al. "Research developments in the syntheses, anti-inflammatory activities and structure–activity relationships of pyrimidines." RSC Advances 11, no. 11 (2021): 6060–98. http://dx.doi.org/10.1039/d0ra10657g.

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28

Putz, Mihai, and Ana-Maria Lacrămă. "Introducing Spectral Structure Activity Relationship (S-SAR) Analysis. Application to Ecotoxicology." International Journal of Molecular Sciences 8, no. 5 (2007): 363–91. http://dx.doi.org/10.3390/i8050363.

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29

Choudhary, Alka N., Arun Kumar, and Vijay Juyal. "Synthesis, Structure Activity Relationship (SAR), and Biological Activities of Benzylideneacetophenones Derivatives." Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 14, no. 3 (2016): 172–82. http://dx.doi.org/10.2174/1871523015666160114092144.

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30

Šepsová, Vendula, Jana Žďárová Karasová, Filip Zemek, Brian J. Bennion, and Kamil Kuča. "OXIMES AS INHIBITORS OF ACETYLHOLINESTERASE - A STRUCTURE-ACTIVITY RELATIONSHIP (SAR) STUDY." Military Medical Science Letters 80, no. 4 (2011): 178–86. http://dx.doi.org/10.31482/mmsl.2011.024.

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31

Lester, Cathy, Allison Reis, Michael Laufersweiler, Shengde Wu, and Karen Blackburn. "Structure activity relationship (SAR) toxicological assessments: The role of expert judgment." Regulatory Toxicology and Pharmacology 92 (February 2018): 390–406. http://dx.doi.org/10.1016/j.yrtph.2017.12.026.

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32

Xu, Changliang, Xiaoguang Bai, Jian Xu, et al. "Substituted 4-oxo-crotonic acid derivatives as a new class of protein kinase B (PknB) inhibitors: synthesis and SAR study." RSC Advances 7, no. 8 (2017): 4763–75. http://dx.doi.org/10.1039/c6ra24953a.

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33

Veríssimo, Gabriel Corrêa, Valtair Severino dos Santos Junior, Philipe Oliveira Fernandes, et al. "GCN-Based Structure-Activity Relationship and DFT Studies of Staphylococcus aureus FabI Inhibitors." International Journal of Quantitative Structure-Property Relationships 7, no. 1 (2022): 1–16. http://dx.doi.org/10.4018/ijqspr.313627.

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The enoyl-[acyl-carrier-protein] reductase (FabI) is an important enzyme in the fatty acid metabolism of Gram-positive bacteria, such as Staphylococcus aureus. FabI is also a potential target for the development of novel antibacterials. Several machine learning-driven studies were reported to develop FabI inhibitors, describing robust and predictive models. Herein, the authors applied the kGCN, a graph convolutional network framework, to generate classification models to select potential S. aureus FabI inhibitors. The most predictive model showed robustness for both active and inactive class p

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34

Faheem, Banoth Karan Kumar, Kondapalli Venkata Gowri Chandra Sekhar, Subhash Chander, Selvaraj Kunjiappan, and Sankaranarayanan Murugesan. "Medicinal chemistry perspectives of 1,2,3,4-tetrahydroisoquinoline analogs – biological activities and SAR studies." RSC Advances 11, no. 20 (2021): 12254–87. http://dx.doi.org/10.1039/d1ra01480c.

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35

Czyzyk, Daniel J., and Erika A. Taylor. "Heptosyltransferase I Lipid a Structure Activity Relationships (SAR)." Biophysical Journal 100, no. 3 (2011): 219a. http://dx.doi.org/10.1016/j.bpj.2010.12.1409.

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36

Myers, Howard M. "Structure-activity relationships (SAR) of hydroxyapatite-binding molecules." Calcified Tissue International 40, no. 6 (1987): 344–48. http://dx.doi.org/10.1007/bf02556697.

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37

Renzetti, Andrea, Jonathan W. Betts, Kozo Fukumoto, and Ryan Noboru Rutherford. "Antibacterial green tea catechins from a molecular perspective: mechanisms of action and structure–activity relationships." Food & Function 11, no. 11 (2020): 9370–96. http://dx.doi.org/10.1039/d0fo02054k.

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38

Yang, Hong, Zhe Du, Wen-Juan Lv, Xiao-Yun Zhang, and Hong-Lin Zhai. "In silico toxicity evaluation of dioxins using structure–activity relationship (SAR) and two-dimensional quantitative structure–activity relationship (2D-QSAR)." Archives of Toxicology 93, no. 11 (2019): 3207–18. http://dx.doi.org/10.1007/s00204-019-02580-w.

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Yasuno, Yoko, Makoto Hamada, Masanori Kawasaki, et al. "(7S)-Kaitocephalin as a potent NMDA receptor selective ligand." Organic & Biomolecular Chemistry 14, no. 4 (2016): 1206–10. http://dx.doi.org/10.1039/c5ob02301g.

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40

Anshul, Anshul, Sanjeev Sharma, and Anil Kumar. "Structure-Activity Relationship Analysis of Novel Compounds Against Drug-Resistant Plasmodium Falciparum Strains." INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT 07, no. 10 (2023): 1–11. http://dx.doi.org/10.55041/ijsrem26166.

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The escalating issue of drug-resistant Plasmodium falciparum strains poses a significant challenge to malaria treatment. This research paper presents a comprehensive analysis of the Structure-Activity Relationship (SAR) of innovative compounds designed to combat drug-resistant malaria. Through systematic examination of the chemical structures and their biological activity, we aim to identify potential drug candidates that can effectively address this global health concern. Our study contributes to the ongoing efforts in antimalarial drug development, offering insights into the design of novel

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41

Doussin, J. F., and A. Monod. "Structure-activity relationship for the estimation of OH-oxidation rate constants of carbonyl compounds in the aqueous phase." Atmospheric Chemistry and Physics Discussions 13, no. 6 (2013): 15949–91. http://dx.doi.org/10.5194/acpd-13-15949-2013.

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Abstract. In the atmosphere, one important class of reactions occurs in the aqueous phase in which organic compounds are known to undertake oxidation towards a number of radicals, among which OH radicals are the most reactive oxidants. In 2008, Monod and Doussin have proposed a new structure activity relationship (SAR) to calculate OH-oxidation rate constants in the aqueous phase. This estimation method is based on the group-additivity principle and was until now limited to alkanes, alcohols, acids, bases and related polyfunctional compounds. In this work, the initial SAR is extended to carbon

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Doussin, J. F., and A. Monod. "Structure–activity relationship for the estimation of OH-oxidation rate constants of carbonyl compounds in the aqueous phase." Atmospheric Chemistry and Physics 13, no. 23 (2013): 11625–41. http://dx.doi.org/10.5194/acp-13-11625-2013.

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Abstract. In the atmosphere, one important class of reactions occurs in the aqueous phase in which organic compounds are known to undergo oxidation towards a number of radicals, among which OH radicals are the most reactive oxidants. In 2008, Monod and Doussin have proposed a new structure–activity relationship (SAR) to calculate OH-oxidation rate constants in the aqueous phase. This estimation method is based on the group-additivity principle and was until now limited to alkanes, alcohols, acids, bases and related polyfunctional compounds. In this work, the initial SAR is extended to carbonyl

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43

Pałkowski, Łukasz, Maciej Karolak, Jerzy Błaszczyński, Jerzy Krysiński, and Roman Słowiński. "Structure-Activity Relationships of the Imidazolium Compounds as Antibacterials of Staphylococcus aureus and Pseudomonas aeruginosa." International Journal of Molecular Sciences 22, no. 15 (2021): 7997. http://dx.doi.org/10.3390/ijms22157997.

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This paper presents the results of structure–activity relationship (SAR) studies of 140 3,3’-(α,ω-dioxaalkan)bis(1-alkylimidazolium) chlorides. In the SAR analysis, the dominance-based rough set approach (DRSA) was used. For analyzed compounds, minimum inhibitory concentration (MIC) against strains of Staphylococcus aureus and Pseudomonas aeruginosa was determined. In order to perform the SAR analysis, a tabular information system was formed, in which tested compounds were described by means of condition attributes, characterizing the structure (substructure parameters and molecular descriptor

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44

Ghahsare, Aref G., Zahra S. Nazifi, and Seyed M. R. Nazifi. "Structure-Bioactivity Relationship Study of Xanthene Derivatives: A Brief Review." Current Organic Synthesis 16, no. 8 (2020): 1071–77. http://dx.doi.org/10.2174/1570179416666191017094908.

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: Over the last decades, several heterocyclic derivatives compounds have been synthesized or extracted from natural resources and have been tested for their pharmaceutical activities. Xanthene is one of these heterocyclic derivatives. These compounds consist of an oxygen-containing central heterocyclic structure with two more cyclic structures fused to the central cyclic compound. It has been shown that xanthane derivatives are bioactive compounds with diverse activities such as anti-bacterial, anti-fungal, anti-cancer, and anti-inflammatory as well as therapeutic effects on diabetes and Alzhe

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45

Goel, Kapil Kumar, Somesh Thapliyal, Rajeev Kharb, Gaurav Joshi, Arvind Negi, and Bhupinder Kumar. "Imidazoles as Serotonin Receptor Modulators for Treatment of Depression: Structural Insights and Structure–Activity Relationship Studies." Pharmaceutics 15, no. 9 (2023): 2208. http://dx.doi.org/10.3390/pharmaceutics15092208.

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Serotoninergic signaling is identified as a crucial player in psychiatric disorders (notably depression), presenting it as a significant therapeutic target for treating such conditions. Inhibitors of serotoninergic signaling (especially selective serotonin reuptake inhibitors (SSRI) or serotonin and norepinephrine reuptake inhibitors (SNRI)) are prominently selected as first-line therapy for the treatment of depression, which benefits via increasing low serotonin levels and norepinephrine by blocking serotonin/norepinephrine reuptake and thereby increasing activity. While developing newer hete

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46

Thapa, Hari Bagale, Najma Bajracharya, Sapana Thapa, and Gan B. Bajracharya. "Synthesis, Structure-Activity Relationship and Antibacterial Activity of Some Simple (E)-Chalcones." Asian Journal of Chemistry 34, no. 11 (2022): 2935–41. http://dx.doi.org/10.14233/ajchem.2022.23930.

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In present work, 14 simple (E)-chalcones (1-14), synthesized via the Claisen-Schmidt condensation between arylmethyl ketone and aromatic aldehyde in the presence of either in NaOH or H3BO3, were tested for in vitro antibacterial activity against two Gram-positive (Staphylococcus aureus and Bacillus subtilis) and three Gram-negative (Escherichia coli, Enterobacter cloacae and Klebsiella pneumoniae) bacterial strains. Among them, (E)-3-(4-hydroxy-3-methoxyphenyl)-1-(3-nitrophenyl)prop-2-en-1-one (8) was found most efficient, while (E)-3-(4-(dimethylamino)phenyl)-1-phenylprop-2-en-1-one (4) and (

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47

Sepsova, Vendula, Jana Karasova, Jan Korabecny, et al. "Oximes: Inhibitors of Human Recombinant Acetylcholinesterase. A Structure-Activity Relationship (SAR) Study." International Journal of Molecular Sciences 14, no. 8 (2013): 16882–900. http://dx.doi.org/10.3390/ijms140816882.

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Gore, Vijay K., Vu V. Ma, Rami Tamir, Narender R. Gavva, James J. S. Treanor, and Mark H. Norman. "Structure–activity relationship (SAR) investigations of substituted imidazole analogs as TRPV1 antagonists." Bioorganic & Medicinal Chemistry Letters 17, no. 21 (2007): 5825–30. http://dx.doi.org/10.1016/j.bmcl.2007.08.044.

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Ahmad, Viqar Uddin, Farman Ullah, Javid Hussain, et al. "Tyrosinase Inhibitors from Rhododendron collettianum and Their Structure–Activity Relationship (SAR) Studies." CHEMICAL & PHARMACEUTICAL BULLETIN 52, no. 12 (2004): 1458–61. http://dx.doi.org/10.1248/cpb.52.1458.

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Ning, Xia, and George Karypis. "In silico structure-activity-relationship (SAR) models from machine learning: a review." Drug Development Research 72, no. 2 (2010): 138–46. http://dx.doi.org/10.1002/ddr.20410.

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