Relevant bibliographies by topics / Sarcoidoses

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Academic literature on the topic 'Sarcoidoses'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Sarcoidoses"

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Hours, S., H. Nunes, M. Kambouchner, Y. Uzunhan, M. Brauner, D. Valeyre, and P. Y. Brillet. "Aspects tomodensitometriques (TDM) initiaux et evolutifs des sarcoidoses cavitaires." Journal de Radiologie 88, no. 10 (October 2007): 1356. http://dx.doi.org/10.1016/s0221-0363(07)81010-9.

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Bruguière, E., J. Marmursztejn, S. Silvera, H. Gouya, L. Guillevin, P. Legmann, and O. Vignaux. "Apports de l’IRM cardiaque dans le bilan des sarcoidoses." Journal de Radiologie 90, no. 10 (October 2009): 1430–31. http://dx.doi.org/10.1016/s0221-0363(09)75639-2.

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Paovic, Jelena, Predrag Paovic, and Miroslav Vukosavljevic. "Clinical and immunological features of retinal vasculitis in systemic diseases." Vojnosanitetski pregled 66, no. 12 (2009): 961–65. http://dx.doi.org/10.2298/vsp0912961p.

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Background/Aim. Vasculitis is a clinical, pathologic process characterized by inflammation and necrosis of blood vessel occurring anywhere in the body. The aim of the study was to present some clinical and immunologic features of retinal vasculitis in systemic diseases: systemic lupus erythematosus, multiple sclerosis, sarcoidosis, Behcet's diseases, and others. Methods. A total of 1 254 patients with uveitis were included in the study. The immunochemical diagnostic methods were used to determine the pathogenesis of ocular manifestations. Ocular manifestations were examined using biomicroscope, direct or indirect ophtalmoscopy. Results. Primary retinal vasculitis was diagnosed in 85/1254 (6.8%) of total uveitis. In more than half of the cases of vasculitis (58.8%), both arteries and veins were involved in inflammatory process. Periphlebitis was diagnosed far more commonly (36.5%) than periarteritis (4.7%). Retinal vasculitis associated with systemic lupus erythematosus was characterized by microinfarctions and the consequent foci of inflammatory cells or diseases of large arteries manifesting in vasospasm and occlusions. Cotton wool spots occurred in 38.3% and retinal hemorrhages in 34% of the cases. In this study periphlebitis of the retina was one of the less frequent ocular manifestations of multiple sclerosis. Comparing with the other changes of the retinal blood vessels, venous sheating occurred in 25.1% and occlusion and vein trombosis in 43.75% of the cases. Retinal vasculitis associated with chronic sarcoidosis occured in 37.5% of patients with sarcoidosis. The most frequent manifestation of ocular sarcoidosis was intermediary uveitis (43.75%). Anterior granulomatous uveitis occured in 37.5% of patients with sarcoidoses. Immune complexes occurred in 13/20 (65%) of the patients. Antiretinal anti-S antibody in the serum occurred in 73% of the patients with retinal detachment as a complication of primary disease and in 25% those with vasculitis. Conclusion. Systemic diseases such as Behcet's syndrome, collagen vascular diseases, systemic granulomatous diseases (sarcoidosis and tuberculosis) were the main causes of retinal vasculitis. Knowledge of the symptomatology and pathogenesis of retinal vasculitis is of the major significance for the diagnosis and therapy of the disease.
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Nawfal, Georges, Christelle Budin, Raymonde Bouvier, and Alain Lachaux. "Elevated Aminotransaminases As the First Manifestation of Sarcoidosis." Case Reports in Medicine 2009 (2009): 1–3. http://dx.doi.org/10.1155/2009/193785.

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Sarcoidose is a rare disease in children. The aminotransaminase level is often normal to moderately elevated (2 to 3 folds of the normal level). We report the case of a child who presented an aminotransaminase level that was 10 times the normal level, as the first manifestation of sarcoidosis.
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Studdy, P. R., and R. Bird. "Serum Angiotensin Converting Enzyme in Sarcoidosis—Its Value in Present Clinical Practice." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 26, no. 1 (January 1989): 13–18. http://dx.doi.org/10.1177/000456328902600102.

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Angiotensin converting enzyme (ACE) has a central role in blood pressure homeostasis. It is present in low and fairly constant concentration in the serum and in high concentration in the pulomonary capillary bed. Unusually high serum angiotensin converting enzyme (SACE) activity is present in active sarcoidosis, an observation now confirmed by many investigators. In spite of its lack of specificity as a test for sarcoidoisis, SACE provides a good monitor of disease activity which clinicians find useful in the management of patients with sarcoidosis. There continues to be considerable interest in SACE in sarcoidosis and with the recent development of simpler assays, more centres may be expected to offer SACE measurements as a service. In this paper we discuss the indications for estimating SACE in sarcoidosis and its relevance to current clinical practice.
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Saylor, Catherine, Nabil Beaini, James Rokos, Keerthana Satheesh, and Charles Cobb. "Primary Manifestation of Sarcoidosis Involving the Gingivae." International Journal of Experimental Dental Science 1, no. 2 (2012): 102–5. http://dx.doi.org/10.5005/jp-journals-10029-1025.

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ABSTRACT Sarcoidois of the gingiva is rarely the primary manifestation of the disease. The following case presentation highlights clinical signs and symptoms that are not uncommon or unusual except for the anatomical location of the initial expression. Appropriate treatment must be based on a definitive diagnosis which, in turn, requires a biopsy for histologic analysis. How to cite this article Saylor C, Beaini N, Rokos J, Satheesh K, Cobb C. Primary Manifestation of Sarcoidosis Involving the Gingivae. Int J Experiment Dent Sci 2012;1(2):102-105.
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Kapoor, Ashutosh, and Ambar Basu. "Hypercalcemia- A Common Abnormality With Uncommon Etiologies." Journal of the Endocrine Society 5, Supplement_1 (May 1, 2021): A198. http://dx.doi.org/10.1210/jendso/bvab048.402.

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Abstract Introduction: Hypercalcemia is a relatively common electrolyte abnormality which is generally associated with Parathyroid related disorders or Cancers. Rare aetiologies comprise of granulomatous disorders and haematological malignancies namely Sarcoidosis and Lymphoma. Parathyroid hormone related Peptide (PTH-rp) and Calcitriol are implicated in causing Hypercalcemia in mentioned aetiologies. Case Details: A 57 year gentleman was admitted following a 10 day history of feeling unwell, unsteadiness in gait, constipation and mild shortness of breath (SOB) on walking uphill. His medical history comprised of Type 1 Diabetes Mellitus (DM) and Hypertension (HTN). Regular medications did not comprise of any drugs that could lead to Hypercalcemia. Biochemic he was Hypercalcemic at 3.14 (2.20–2.60). Parathyroid Hormone levels (PTH) was 0.6 (1.1–4.7 pmol/l) which excluded Parathyroid driven aetiologies. ACE levels were normal and Myeloma screen was negative. 25-OH Vitamin D levels were within Normal limits. Management: Hypercalcemia was managed with Intravenous Fluids and optimum hydration which improved his Calcium levels, followed by subsequent normalisation. Given his suppressed PTH levels, he underwent whole body imaging to assess for evidence of underlying occult malignancy. The CT imaging of his chest, abdomen and pelvis revealed widespread Lymphadenopathy and hypodense lesions in the Spleen. The report stated likely Sarcoidosis accompanied by Splenic involvement, with the main differentials being Sarcoidois versus Lymphoproliferative disorder. This was discussed with the respiratory team and Steroids were not commenced taking into account the improvement in his Calcium levels following adequate hydration and fluids. The patient has been kept under close follow up with ongoing monitoring of his clinical status. Summary: Hypercalcemia has been described in patients with Granulomatous disorders and Haematological malignancies. The incidence of hypercalcemia in Sarcoidosis is estimated to be approximately 10%, with no association with a specific demographic. Granulomatous disorders and Haematological malignancies constitute the rare aetiologies of hypercalcemia and are characterised by a low-normal or suppressed PTH level. Diagnosis of Sarcoidosis is often challenging with the lack of gold standard tests. Serum ACE levels can be within normal limits in people with Sarcoidosis despite not being on Steroid therapy. Evaluation of serum PTH-rp and Calcitriol can aid in diagnosis and more importantly assisting in prognostication, thus guiding further management.
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Mahévas, Matthieu, Laurent Chiche, Medhi Khellaf, Yurdagu Uzunhan, Anne-Sophie Morin, Véronique Perronne, Louis Affo, et al. "Characteristics of Sarcoidosis-Associated Immune Thrombocytopenia: a Consecutive Study of 20 Cases." Blood 114, no. 22 (November 20, 2009): 2407. http://dx.doi.org/10.1182/blood.v114.22.2407.2407.

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Abstract Abstract 2407 Poster Board II-384 Introduction: Although sarcoidosis is far from being a classical cause of secondary-immune thrombocytopenic purpura (ITP), isolated thrombocytopenia may occur during the course of the disease. To better assess the main characteristics and outcome of patients with a sarcoidosis-associated ITP, a survey was initiated throughout the French study group on sarcoidosis and the national referral center for adult's immune cytopenias. The data of the 20 first cases are reported. Patients and Methods: To be included, all patients had to fulfil the following criteria: 1) Definite diagnosis of sarcoidosis according to the standard international criteria (Am J Respir Crit Care Med 1999; 736-55) and 2) Presence of an immune thrombocytopenia according to the ASH criteria twith platelet count below 100 × 109/L on at least two separate occasions 2 weeks. Drug-induced thrombocytopenia were excluded as well as patients with a hypogammaglobulinemia suggesting a underlying common variable immunodeficiency (CVI) and thrombocytopenia related to hypersplenism. All clinical and biological data were reviewed and analyzed by the same investigator by using a standard form. A complete response (CR) was defined as sustained (> 3months) platelet count > 100 × 109/L with at least a twofold increase for baseline. A partial response (PR) was defined as a platelet count 30×109/L or more and at least twice the initial value. Results: Twenty patients (50% men) were included. Median age at ITP diagnosis was 37.5 years (21 to 83) and median age at sarcoidosis diagnosis was 36 yrs (10 to 83). In 4 patients, ITP preceded the diagnosis of sarcoidosis (median: 67.5 months; 15 to 153). In 11 patients (55%), ITP occurred in the course of prior diagnosed sarcoidosis with a median of 48 mths (6 to 216), and concomitantly with the diagnosis of sarcoidosis in 5 patients (25%). In 13 patients (65%), an active localization of sarcoidosis was present at the diagnosis of ITP. Median platelet count at onset was 11×109/L (3 to 90) and nadir platelet count was 10×109/L (1 to 60). Seven patients (35%) had severe (mucosal) bleeding manifestations and a bleeding score ≥ 8 (described by Khellaf et al). Regarding sarcoidosis, during the follow up, 17 patients (85%) had thoracic involvement, and an extra-thoracic involvement was found in 14 patients (70%) including: eye (n=7), liver (n=5), sinus (n=4), peripheral lymph nodes (n=4), skin (n=3), salivary gland (n=2), spleen (n=1) and kidney (n=1). Nineteen out of the 20 patients were treated specifically for their secondary ITP. After the first line therapy (prednisone at 1mg/kg/day for at least 3 consecutive weeks in all patients associated with IVIg in 10 patients), 12/19 (63%) patients achieved a complete response (CR), 6 a partial response (PR) (32%) and only 1 patient failed to respond. The course of ITP was chronic in 4 patients, among them 2 underwent splenectomy and achieved a CR and 2 were treated with Rituximab (375mg/m2, 4 infusions) and achieved a PR at one year. After a median follow up of 70 months (12 to142), 18 patients (90%) were in CR and 2 in PR with chronic ITP. Eight patients were in remission off therapy whereas 12 patients (60%) were still on corticosteroids at time of analysis with a median dose of 10mg/day (5 to 30). During the follow-up period, 11 patients (55%) had a relapse or flare of sarcoidosis (intra thoracic in 5 patients, extra-thoracic in 6 patients). In 2 patients, a simultaneous relapse of both sarcoidoisis and associated-ITP was observed. Comments: Our preliminary data suggest that the association of sarcoidosis and ITP is not fortuitous and that sarcoidosis should be considered as a potential cause of secondary ITP. ITP in this setting is frequently initially severe and symptomatic and therefore requiring treatment. The overall response rate to treatments commonly used in primary ITP is however good and the long term outcome is favorable suggesting that patients with sarcoidosis-associated ITP should be managed as patients with primary ITP. In contrast, relapse of sarcoidosis is frequent and frequently affect extra-thoracic sites. That a majority of the patients had an active and/or relapsing sarcoidosis during the course of ITP suggests that granuloma may be a predisposing condition for triggering autoimmunity and especially ITP as observed in some cases of CVI-associated immune thrombocytopenia. Disclosures: No relevant conflicts of interest to declare.
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Akimov, V. G. "Manifestations of Besnier-Boeck-Schaumann sarcoidosis on skin." Medical alphabet, no. 6 (June 16, 2020): 83–86. http://dx.doi.org/10.33667/2078-5631-2020-6-83-86.

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Besnier-Boeck-Schaumann sarcoidosis is a multisystemic disease of unknown etiology. Only about 25 % of patients have cutaneous involvement. Every patient with cutaneous sarcoidosis should be evaluated for possible systemic sarcoidosis. This article contains descriptions and original images of clinical forms of the disease: miliary sarcoidosis, circinate sarcoidosis, nodular sarcoidosis, angiolupoid (Brocq-Potrier), lupus pernio (Besnier-Tennesson), erythema nodosum, subcutaneous sarcoidosis (Darier-Roussy). Differential diagnosis and treatment of patients are discussed.
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Chen, Jacob, Robert Carter III, Daniel Maoz, Ana Tobar, Eran Sharon, and Franklin Greif. "Breast Cancer and Sarcoidosis: Case Series and Review of the Literature." Breast Care 10, no. 2 (2015): 137–40. http://dx.doi.org/10.1159/000381324.

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Background: Sarcoidosis is a chronic inflammatory disease of unknown etiology, which can involve different organs and systems. Accordingly, sarcoidosis can mimic breast cancer, making the differential diagnosis very difficult. Case Report: 5 patients with a diagnosis of both sarcoidosis and breast cancer followed by the Rabin Medical Center between January 1993 and June 2012 were enrolled in this study. Additionally, a comprehensive literature review which identified 104 patients diagnosed with breast cancer and sarcoidosis was carried out. In both populations reviewed, the average age at diagnosis of sarcoidosis and breast cancer was 57 years. Among the 66 patients with both sarcoidosis and breast cancer, sarcoidosis preceded breast cancer in 31 cases, followed it in 23 cases, and appeared concurrently in 10 cases. Conclusion: Based on our clinical cases and literature review, a histological study is recommended over imaging if sarcoidosis or breast cancer may be present. Furthermore, breast cancer is rarely associated with sarcoidosis or sarcoidosis-like reaction.
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Dissertations / Theses on the topic "Sarcoidoses"

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Coelho, Mariana Guimarães. "Histopatologia da paracoccidioidomicose : granuloma sarcoide e formas pequenas do paracoccidioides." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/143063.

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A paracoccidioidomicose (PCM) é uma infecção sistêmica causada pelo fungo Paracoccidioides sp. A doença é endêmica na maior parte dos países da América Latina, sendo os pulmões os órgãos mais afetados. O diagnóstico de PCM é feito com base na história clínica e epidemiológica, e confirmado pela visualização microscópica das estruturas fúngicas do Paracoccidioides a partir de secreções ou tecidos. Por vezes, a apresentação clínica e os achados histopatológicos da PCM simulam os de outras doenças, como a sarcoidose, e ocasionalmente são encontradas nas lesões formas excepcionalmente pequenas do Paracoccidioides, que podem ser confundidas com outros fungos, como o Histoplasma capsulatum. O presente trabalho objetivou identificar e caracterizar os casos que simularam sarcoidose e os que apresentaram formas pequenas de Paracoccidioides dentre os 856 casos de paracoccidioidomicose diagnosticados no Laboratório de Micologia do Complexo Hospitalar Santa Casa de Porto Alegre, no período de 1981 a dezembro de 2013. Foram identificados 8 casos mimetizando a sarcoidose e 12 apresentando formas pequenas de Paracoccidoides. Dos casos que simularam a sarcoidose, todos eram fumantes do sexo masculino, com idades variando entre 27 e 59 anos (média = 42,5 anos) e apresentaram tosse produtiva, infiltrado fibronodular bilateral aos exames de imagem e granulomas sarcoides na biópsia pulmonar, recebendo prednisona como tratamento inicial. O diagnóstico de PCM, nestes casos, foi realizado por meio de cortes histológicos corados ao GMS (n=8), exame direto do escarro (n=2) e imunodifusão (n=4). Dentre os casos que apresentaram formas pequenas do Paracoccidioides, todos eram fumantes, tinham idades variando entre 33 e 68 anos (média = 55,58 anos), 10 eram do sexo masculino, e 10 apresentavam sintomas consistentes com os da PCM (dois pacientes eram assintomáticos). O diagnóstico etiológico, em todos os casos, foi realizado por meio de cortes histológicos seriados corados ao GMS (que revelaram as formas multibrotantes patognomônicas do Paracoccidioides) e corroborado por exame direto do escarro (n=3), imunodifusão (n=6) e cultura (n=1). Com isto, ressalta-se a importância da consideração dos diagnósticos diferenciais da paracoccidioidomicose. Visto que a sarcoidose é um diagnóstico de exclusão, o achado de granulomas epitelioides sem necrose deve incitar a busca ativa por agentes etiológicos com a utilização das colorações de ZN e GMS. E nos casos em que se encontram formas pequenas ou pouco usuais do Paracoccidioides, devem-se realizar cortes histológicos seriados e escalonados corados ao GMS e utilizar técnicas laboratoriais complementares, como imunodifusão e cultura, para assegurar o seu diagnóstico.
Paracoccidioidomycosis (PCM) is a systemic infection caused by the fungus Paracoccidioides sp. The disease is endemic in most Latin American countries, and the lungs are the most affected organs. The diagnosis of PCM is based on clinical and epidemiological features, and confirmed by the microscopic visualization of yeasts of Paracoccidioides from clinical specimens. Sometimes the clinical presentation and histopathological findings of PCM mimic those of other diseases, such as sarcoidosis, and occasionally exceedingly small forms of Paracoccidioides are found in lesions, which can be confused with other fungi, such as Histoplasma capsulatum. This study aimed to identify and characterize the cases that simulated sarcoidosis and those with small forms of Paracoccidioides among the 856 cases of paracoccidioidomycosis diagnosed in the Mycology Laboratory of the Hospital Complex Santa Casa de Porto Alegre, from 1981 to December 2013. 8 cases were identified mimicking sarcoidosis and 12 with small forms of Paracoccidoides. All the cases that mimicked sarcoidosis were male smokers, aged between 27 and 59 years (mean = 42.5 years) and had productive cough, bilateral fibronodular infiltrates on X-ray and sarcoid granulomas in the lung biopsy, receiving prednisone as initial treatment. The diagnosis of PCM in these cases was carried out by histological sections stained with GMS (n = 8), direct examination of sputum (n = 2) and immunodiffusion (n = 4). Among the cases with small forms of Paracoccidioides, all were smokers, aged between 33 and 68 years (mean = 55.58 years), 10 were male, and 10 had symptoms consistent with PCM (two patients were asymptomatic). The etiologic diagnosis in all the 12 cases was made by serial tissue sections stained with GMS (which revealed the multibudding pathognomonic forms of Paracoccidioides) and confirmed by direct examination of sputum (n = 3), immunodiffusion (n = 6) and culture (n = 1). In conclusion, it is emphasized the importance of considering the differential diagnosis of paracoccidioidomycosis. Since sarcoidosis is a diagnosis of exclusion, the finding of epithelioid granulomas without necrosis should encourage the active search for etiologic agents with the use of ZN and GMS stains. And in cases in which small or unusual forms of Paracoccidioides are found, serial histological sections stained with GMS and complementary laboratory techniques such as immunodiffusion and culture should be performed to ensure their diagnosis.
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Foley, Patrick James. "Immunogenetic predisposition in sarcoidosis." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399271.

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Araújo, Ana Rafaela da Silva. "Caracterização dos doentes com diagnóstico de sarcoidose do serviço de pneumologia do CHCB entre os anos de 2001 e 2010." Master's thesis, Universidade da Beira Interior, 2011. http://hdl.handle.net/10400.6/892.

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Introdução: A Sarcoidose é a doença pulmonar intersticial mais frequente. Afecta predominantemente adultos jovens e caracteriza-se pela presença de adenopatias hilares bilaterais, infiltrados pulmonares, lesões oculares e cutâneas, mas virtualmente qualquer órgão pode estar envolvido. O diagnóstico é estabelecido quando os achados clínico-radiológicos são suportados pela evidência histológica de granulomas não caseosos. Níveis aumentados de enzima conversora de angiotensina e metabolismo anormal do cálcio são dois marcadores de actividade da patologia. A corticoterapia permanece o marco do tratamento e a remissão espontânea é comum, contudo alguns doentes evoluem para a cronicidade. Permanece um diagnóstico desafiante, pela imprevisibilidade que a caracteriza, afectando todos os doentes de forma diferente. Objectivos: Caracterizar epidemiologicamente e clinicamente os doentes com diagnóstico de Sarcoidose do Serviço de Pneumologia do CHCB e realizar correlação dos resultados com o estado da arte. Material e métodos: foi realizada a análise dos processos clínicos individuais dos doentes adultos com diagnóstico de Sarcoidose do Serviço de Pneumologia do CHCB, entre os anos de 2001 e 2010, incluindo os doentes internados e não internados, recorrendo a informações cedidas pelo Serviço de Pneumologia para a constituição da amostra. Para o tratamento estatístico recorreu-se a testes de estatística descritiva e ao t-student na comparação de grupos. Resultados: A média de idades dos 34 doentes da amostra foi de 47,26 anos, sendo a maioria dos doentes do sexo feminino (22). Quanto aos hábitos tabágicos, a maioria era não fumadora (85%). As principais ocupações desempenhadas pelos pacientes na altura do diagnóstico foram a indústria têxtil (oito) e serviços administrativos (sete). O eritema nodoso foi o sintoma inicial mais frequente. 56% da amostra analisada apresentava um estudo funcional respiratório normal e em 11 doentes foi encontrada uma alteração obstructiva. A capacidade de difusão do monóxido de carbono (DLCO) estava normal em 82% do grupo analisado. Na radiografia do tórax, o reforço hilar bilateral estava presente em 53% dos doentes. Na TC torácica, o padrão micronodular (nove) e as adenopatias mediastínicas e hilares bilaterais (15) foram os achados mais frequentes. Dos doentes que realizaram lavado broncoalveolar, dez apresentavam uma relação CD4/CD8 superior a 3,5. O procedimento mais realizado para obtenção do diagnóstico histológico foi a mediastinoscopia (56%). A enzima conversora de angiotensina estava aumentada em 50% da amostra, a velocidade de sedimentação em 24%, a calcémia em 12%, a calciúria e a creatinina em 9% e a fosfatase alcalina em 12%. A maioria dos doentes iniciou tratamento médico no momento do diagnóstico (79%), sendo que nove destes doentes cessaram o mesmo por remissão da doença. Contudo três reiniciaram corticoterapia por doença recidivante. A fibrose pulmonar foi a complicação mais frequente (12%), mas a maioria da amostra (79%) não desenvolveu complicações. Conclusões: Verificou-se que a maioria dos resultados obtidos para a amostra analisada estão de acordo com a literatura vigente, nomeadamente em relação ao género acometido, aos hábitos tabágicos, à sintomatologia inicial, dominada pelo envolvimento cutâneo, ocular e pulmonar, estudo funcional respiratório, alterações na radiografia do tórax e TC torácica, relação CD4/CD8, tratamento realizado e complicações desenvolvidas durante a evolução. O mesmo não se verificou na totalidade para a idade do diagnóstico, modalidade de biópsia utilizada e alguns parâmetros analíticos estudados. A Sarcoidose é uma doença com grande variabilidade à apresentação, com inúmeras dificuldades diagnósticas e com um curso imprevisível, sendo um terreno fértil para a investigação.
Introduction: Sarcoidosis is the most common interstitial lung disease. It affects primarily young adults and it is characterized by the presence of bilateral hilar adenopathy, pulmonary infiltrates, skin and eye damage, however virtually any organ can be involved. The diagnosis is established when the clinical and radiographical findings are supported by histological evidence of noncaseating granulomas. Increased levels of angiotensin converting enzyme and abnormal calcium metabolism are two markers of disease activity. Corticosteroid therapy remains the hallmark of treatment and spontaneous remission is common, but some patients progress to chronicity. Remains a challenging diagnosis due to its characteristic unpredictability, affecting every patient differently. Objectives: To clinically and epidemiologically characterize the patients diagnosed with Sarcoidosis of the Pneumology Department of CHCB and perform correlation of the results with current literature. Materials and Methods: We performed an analysis of the individual clinical files of adult patients diagnosed with Sarcoidosis of the Pneumology Department of CHCB, between 2001 and 2010, including inpatients and outpatients, using information provided by the Department of Pneumology for the formation of sample. For statistical tests we used descriptive statistics and t-student in the comparison group. Results: The average age of the 34 patients in the sample was 47.26 years, and most patients were female (22). Regarding smoking habits, the majority were non smokers (85%). The main occupations performed by patients at diagnosis were the textile industry (eight) and administrative services (seven). Erythema nodosum is the most common initial symptom. 56% of the sample had a normal lung function and in 11 patients was found an obstructive change. The diffusing capacity for carbon monoxide (DLCO) was normal in 82% of the analyzed group. On chest radiograph, bilateral hilar strengthening was present in 53% of patients. On CT scan, the micronodular pattern (nine) and bilateral hilar and mediastinal adenopathy (15) were the most frequent findings. Among the patients who underwent bronchoalveolar lavage, ten had a CD4/CD8 ratio greater than 3,5. The procedure most often performed to obtain the histological diagnosis was mediastinoscopy (56%). The angiotensin converting enzyme was increased in 50% of the sample, erythrocyte sedimentation rate in 24%, increased calcium blood levels in 12%, calciuria and creatinine in 9% and alkaline phosphatase in 12%. Most patients started treatment at the time of diagnosis (79%), and nine of these patients stopped the treatment because of disease remission. However three of these patients restarted corticosteroid therapy because of disease recurrence. Pulmonary fibrosis was the most frequent complication (12%), but most of the sample (79%) developed no complications. Conclusions: We found that most of the results obtained for the analyzed sample are consistent with the current literature, particularly with regard to the affected gender, smoking habits, the initial symptoms, dominated by cutaneous, ocular and pulmonary involvement, lung function studies , changes on chest radiograph and CT scan, CD4/CD8 ratio, performed treatment and complications developed during evolution. The same was not true for the age at diagnosis, type of biopsy utilized and some analytical parameters studied. Sarcoidosis is a disease with great variability at presentation, with numerous diagnostic difficulties and with an unpredictable course, being a fertile ground for research.
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BAUDOIN, MARIE-FRANCE. "La sarcoidose de l'enfant." Nancy 1, 1992. http://www.theses.fr/1992NAN11028.

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Boruchowicz, Arnaud. "Sarcoidose et tube digestif." Lille 2, 1993. http://www.theses.fr/1993LIL2M136.

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Amiel, Olivier. "Erythroblastopenie chronique et sarcoidose." Aix-Marseille 2, 1994. http://www.theses.fr/1994AIX20161.

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Rosa, Bárbara Santa. "Sarcoidose, dúvidas ou certezas? : proposta de protocolos de abordagem ao doente." Master's thesis, Universidade da Beira Interior, 2009. http://hdl.handle.net/10400.6/1019.

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Introdução: A Sarcoidose permanece uma das doenças mais desafiadoras em medicina. Pode afectar qualquer sistema de órgãos e apresentar uma grande variedade de sinais e sintomas. Apesar da resolução espontânea da doença ser a regra a evolução para a cronicidade ocorre em 10 a 30% dos doentes e 5 a 8% vão eventualmente morrer, sendo a principal causa de morte a insuficiência respiratória. Objectivo: Fazer uma revisão teórica e propor protocolos de diagnóstico, tratamento e seguimento com base nos últimos avanços científicos sobre a Sarcoidose, podendo por ventura melhorar a abordagem a estes doentes e impulsionar mais estudos sobre a etiologia e a patogénese da doença. Métodos: Recolha de bibliografia através das bases de dados digitais tais como PubMed, Portal B-on e Cochrane com os termos “Sarcoidosis” e “historic review”, “epidemiology”, “diagnosis”, “course and prognosis”, “treatment”, “follow-up”, “guidelines”. Nos idiomas Português, Inglês, Francês e Espanhol. Discussão: A Sarcoidose é uma doença multissistémica. A sua incidência é de sensivelmente 16.5/100 000 nos homens e de 19/100 000 nas mulheres. Pode atingir qualquer órgão. Sintomas mais comuns são dispneia, tosse e dor torácica. É comum o aparecimento de adenopatias hilares bilaterais e infiltrados pulmonares difusos na radiografia e lesões na pele ou oculares. O granuloma não caseoso é histologicamente característico da Sarcoidose. O diagnóstico faz-se através da apresentação clínica e curso da doença, por exclusão de outras doenças granulomatosas e, na maioria dos casos, por confirmação histológica através de biopsia dos granulomas. O diagnóstico diferencial é extenso e deve incluir infecção e neoplasia. As indicações para tratamento são doença pulmonar sintomática, deterioração da doença pulmonar, hipercalcemia e envolvimento extra-pulmonar. Muitos doentes com alterações na radiografia do tórax e nos testes de função pulmonar têm doença crónica estável e não requerem terapêutica. Os corticoesteróides são a terapêutica de primeira linha. Cerca de 60% dos doentes sofrem recaída. Conclusão: Apesar dos avanços na compreensão da patogénese e tratamento da doença, muitos enigmas permanecem. A procura de um agente estiológico continua. Existem dúvidas sobre o mecanismo envolvido na destruição inflamatória que ocorre nos granulomas não caseosos da Sarcoidose. A avaliação laboratorial da actividade da doença baseia-se em testes inespecíficos, sendo importante descobrir biomarcadores mais específicos. Na área do tratamento há ainda controvérsia sobre quais os doentes a tratar e qual a terapêutica mais adequada. São necessários mais estudos em nestas áreas.
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Pereira, Marisa. "Sarcoidose : estudo de 138 casos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 1994. http://hdl.handle.net/10183/118302.

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A autora estudou 138 pacientes com o diagnóstico de sarcoidose, sendo esta uma das maiores séries do Brasil. Estes pacientes foram atendidos no Pavilhão Pereira Filho, Serviço de Doenças Pulmonares, da Santa Casa de Misericórdia de Porto Alegre, no período de 1967 a 1989. Os objetivos do trabalho foram avaliar os critérios disponíveis em nosso meio para investigação diagnóstica, estadiamento, tratamento e estabelecimento do prognóstico da doença. O protocolo aplicado nesta série p~ocurou delinear o quadro cl ínico, radiológico e laboratorial. Foram incluídos no trabalho 79 mulheres (57%) e 59 homens (43%), dos quais 106 brancos (77%) e 32 pretos (23%), com idades entre 4 e 77 anos, e média de 31 anos. Os resultados obtidos foram comparados aos da 7ª Conferência Internacional sobre Sarcoidose (1975). Assim, encontrou-se 82% dos casos com menos de 40 anos de idade, o que demonstrou uma diferença estatisticamente significativa em relação ao estudo multicêntrico de 3.676 casos, que apresentou 68%. Não houve diferença quanto ao sexo. Tanto a presente série quanto o estudo multicêntrico mostraram uma grande proporção de negros. Em 98,5% da série houve envolvimento intratorácico; no estudo multicêntrico, 92%. O perfil clínico demonstrou um índice significativo de linfonodos periféricos (30,5%) e de lesões oculares (18,8%). Em 79% dos casos sintomáticos o tempo do início dos sintomas foi inferior a dois anos. Não houve diferença significativa nos percentuais de casos dos tipos radiológicos I e 11 (38,4% e 36,2%, respectivamente). Houve menor incidência dos tipos radiológicos O e I em comparação com O· estudo multicêntrico. Houve comprometimento ocular detectado somente através de angiografia ocular com fluoresceína em 10/46 casos (21 ,7%). O teste tuberculínico foi negativo em 91,0% dos casos, enquanto na série multicêntrica o foi em 64%. Houve 11 crianças com sarcoidose fazendo parte desta série. O tratamento com corticóide mostrou-se efetivo em 67% dos casos tratados.
The author studied 138 sarcoidosis patients, which represents one of the largest Brazilian series. The patients were attended at the Pavilhão Pereira Filho, Pulmonary Disease Service, of the Santa Casa de Misericórdia de Porto Alegre, from 1967 to 1989. The purposes of the study were to define practical criteria to diagnose, stage, treat and also to establish the prognosis of the disease. The protocol had as main purpose the delineation of the clinicai, radiological and laboratorial picture. The study included 79 women (57%) and 59 men (43%), 106 Caucasians (77%) and 32 Negroes (23%), aging between 4 and 77 years, averaging 31. The results were compared to those of the 7th lnternational Conference on Sarcoidosis (1975). lt was observed 82% of patients aging less than 40 years old, which showed a statistically significant difference in relation to the multicentric study of 3,676 cases, which presented 68%. No difference was found in respect to sex. 8oth studies demonstrated a high proportion of Negroes. There was intrathoracic involvement in 98.5% of our series, and in 92% of the multicentric study. lt was observed a significant involvement of peripheral nades (30.5%) and ophtalmic abnormalities (18.8%). In 79% of symptomatic patients the beginning time of symptoms were less than two years. Radiological types I and 11 were proportionally equivalent (38.4% and 36 .2%, respectively). lncidence of radiological types O and I were lower when compared to the multicentric study. There was ocular abnormality detected only by fluorescein ocular angiography in 1 O of 46 patients (21.7%) . Tuberculin test was negative in 91.0%, against 64% of the multicentric series. There were 11 children with sarcoidosis in this series. Treatment with steroids showed effectiveness in 67% of the treated patients.
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Wasfi, Yasmine S. "Apoptosis-related genetic polymorphisms in sarcoidosis /." Connect to full text via ProQuest. IP filtered, 2005.

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Crawshaw, Anjali Priya. "Monocyte profile and function in sarcoidosis." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:3378bf46-a494-45a0-b68e-81b37c1dae49.

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Sarcoidosis is a multisystem inflammatory disorder of unknown aetiology. The immune pathology is characterised by dysregulated T cell (TH1) activity, macrophage activation and granuloma formation, resulting in systemic inflammation, and organ dysfunction. I hypothesised that, as the systemic precursor to the macrophage, altered monocyte activity in sarcoidosis may contribute to the early immune pathology of the disease. In this thesis, I examined their phenotype, four key monocytic functions: cytokine production, suppression of T cell proliferation, phagocytosis and fusion (as a precursor to granulomagenesis); and their gene expression profile compared to monocytes from healthy controls. My data show that the expanded monocyte compartment comprise a greater proportion of the inflammatory (CD14++CD16+) and patrolling (CD14+CD16++) subsets, increased TNFα and IL-12 and decreased IL-10 and IL-4 production in sarcoidosis compared with healthy controls. The IL-10 deficit renders the monocytes less able to regulate T cell proliferation or their own fusion to multinucleate giant cells, potentially contributing to T cell expansion and granuloma formation respectively. Additionally, sarcoidosis monocytes are less able to phagocytose inert material. I also showed that previously reported deficiency in invariant NKT cells and low serum vitamin D levels in sarcoidosis may be linked to reduced IL-10 production by monocytes. Vitamin D treatment in vitro restored most of these deficiencies and provides a potential therapeutic method for manipulating monocyte function and disease genesis in sarcoidosis.
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Books on the topic "Sarcoidoses"

1

G, Scadding J., ed. Sarcoidosis. London: Hodder Arnold, 2012.

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N, Mitchell D., ed. Sarcoidosis. 2nd ed. London: Chapman & Hall, 1985.

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Scadding, J. G., and D. N. Mitchell. Sarcoidosis. Boston, MA: Springer US, 1985. http://dx.doi.org/10.1007/978-1-4899-2971-6.

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Judson, Marc A., ed. Pulmonary Sarcoidosis. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4614-8927-6.

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Freeman, Andrew M., and Howard D. Weinberger, eds. Cardiac Sarcoidosis. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-14624-9.

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Nagata, Alfrieda. Understanding sarcoidosis. [Bethesda, Md.?]: Clinical Center Communications, National Institutes of Health, 1988.

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Jones, Williams W., ed. Sarcoidosis and other granulomatous disorders. Philadelphia: Saunders, 1985.

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Connor, Michael R., and Ryan S. Stevens. Sarcoidosis: Diagnosis, epidemiology, and treatment options. Hauppauge, N.Y: Nova Science Publishers, 2011.

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Parker, James N., and Philip M. Parker. The official patient's sourcebook on sarcoidosis. Edited by Icon Group International Inc. San Diego, Calif: Icon Health Publications, 2002.

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P, Sharma Om, ed. Atlas of sarcoidosis: Pathogenesis, diagnosis, and clinical features. New York: Springer, 2005.

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Book chapters on the topic "Sarcoidoses"

1

Scadding, J. G., and D. N. Mitchell. "Historical Survey." In Sarcoidosis, 1–12. Boston, MA: Springer US, 1985. http://dx.doi.org/10.1007/978-1-4899-2971-6_1.

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Scadding, J. G., and D. N. Mitchell. "Superficial Lymphadenopathy." In Sarcoidosis, 252–59. Boston, MA: Springer US, 1985. http://dx.doi.org/10.1007/978-1-4899-2971-6_10.

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Scadding, J. G., and D. N. Mitchell. "The Liver." In Sarcoidosis, 260–73. Boston, MA: Springer US, 1985. http://dx.doi.org/10.1007/978-1-4899-2971-6_11.

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Scadding, J. G., and D. N. Mitchell. "The Spleen and the Blood." In Sarcoidosis, 274–89. Boston, MA: Springer US, 1985. http://dx.doi.org/10.1007/978-1-4899-2971-6_12.

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Scadding, J. G., and D. N. Mitchell. "The Upper Respiratory Tract." In Sarcoidosis, 290–301. Boston, MA: Springer US, 1985. http://dx.doi.org/10.1007/978-1-4899-2971-6_13.

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Scadding, J. G., and D. N. Mitchell. "The Nervous System." In Sarcoidosis, 302–28. Boston, MA: Springer US, 1985. http://dx.doi.org/10.1007/978-1-4899-2971-6_14.

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Scadding, J. G., and D. N. Mitchell. "The Heart." In Sarcoidosis, 329–48. Boston, MA: Springer US, 1985. http://dx.doi.org/10.1007/978-1-4899-2971-6_15.

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Scadding, J. G., and D. N. Mitchell. "The Endocrine Glands." In Sarcoidosis, 349–65. Boston, MA: Springer US, 1985. http://dx.doi.org/10.1007/978-1-4899-2971-6_16.

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Scadding, J. G., and D. N. Mitchell. "The Gastro-intestinal tract." In Sarcoidosis, 366–78. Boston, MA: Springer US, 1985. http://dx.doi.org/10.1007/978-1-4899-2971-6_17.

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Scadding, J. G., and D. N. Mitchell. "The Genito-urinary System, excluding Kidney; the Breast." In Sarcoidosis, 379–89. Boston, MA: Springer US, 1985. http://dx.doi.org/10.1007/978-1-4899-2971-6_18.

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Conference papers on the topic "Sarcoidoses"

1

Burke, Leanne, Mark Kon, and Badie Jacob. "Pleural Sarcoidosis." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a1470.

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Mody, M., A. Arjuna, P. S. Patel, and T. Anandarangam. "Sarcoidosis Again?" In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a1552.

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Sollors, J., B. Schlevogt, H. Schmidt, MA Wörns, PR Galle, R. Bergner, S. Hetjens, CA Weis, M. Ebert, and A. Teufel. "Hepatic sarcoidosis." In 37. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber. Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/s-0040-1722012.

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Schweitzer, Michael, Oriana Salamo, Miguel Pardinas Gutierrez, Loula Asharhan, Michael Campos, Mehdi Mirsaeidi, and Rafael Calderon-Candelario. "Timing of cardiac sarcoidosis in patients with sarcoidosis>." In ERS International Congress 2017 abstracts. European Respiratory Society, 2017. http://dx.doi.org/10.1183/1393003.congress-2017.pa360.

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Jastrzebski, Dariusz, Beata Toczylowska, Sabina Kostorz, Elzbieta Zieminska, Karolina Zieleznik, Dariusz Ziora, and Jerzy Kozielski. "Lipidomics in sarcoidosis." In Annual Congress 2015. European Respiratory Society, 2015. http://dx.doi.org/10.1183/13993003.congress-2015.pa3317.

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Sardi, Alejandro H., Juan Cadavid, and Glenn Eiger. "HIV And Sarcoidosis." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a6662.

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Hussain, Muhammad, Hazim Mahdi, and Mohammed Hassan. "Prevalence of ocular sarcoidosis in patients with intra thoracic sarcoidosis." In ERS International Congress 2016 abstracts. European Respiratory Society, 2016. http://dx.doi.org/10.1183/13993003.congress-2016.pa3730.

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Hena, K., S. Murphy, Y. Zhang, Y. Shao, and J. Reibman. "Sarcoidosis Vs. Sarcoidosis: A Unique Phenotype in WTC Exposed Survivors." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2496.

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Moskalets, O. V. "Autoantibodies in pulmonary sarcoidosis." In General question of world science. "Science of Russia", 2019. http://dx.doi.org/10.18411/gq-31-07-2019-37.

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kyaw, yadana, michael lippmann, manjula balasubramanian, and hernan zarate. "Sarcoidosis - The Great Masquerader." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a5407.

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Reports on the topic "Sarcoidoses"

1

Sudden cardiac death due to myocardial sarcoidosis claims the life of an on-duty fire fighter - Connecticut. U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, December 2003. http://dx.doi.org/10.26616/nioshfffacef200308.

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Fire fighter collapses at the fire house and subsequently dies due to heart arrhythmia secondary to myocardial sarcoidosis - New Jersey. U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, November 2000. http://dx.doi.org/10.26616/nioshfffacef200031.

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