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Journal articles on the topic 'SARS-CoV-2 – physiopathologie'

Author: Grafiati

Published: 30 November 2024

Last updated: 31 July 2025

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1

Salinas, Sara, and Yannick Simonin. "Les atteintes neurologiques liées au SARS-CoV-2 et autres coronavirus humains." médecine/sciences 36, no. 8-9 (2020): 775–82. http://dx.doi.org/10.1051/medsci/2020122.

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L’émergence récente d’un nouveau coronavirus, le SARS-CoV-2, responsable de la maladie appelée COVID-19, est un nouvel avertissement du risque pour la santé publique représenté par les zoonoses virales et notamment par les coronavirus. Principalement connus pour leur capacité à infecter les voies respiratoires supérieures et inférieures, les coronavirus peuvent également affecter le système nerveux central et périphérique, comme c’est le cas pour de nombreux virus respiratoires, tels que les virus influenza ou le virus respiratoire syncytial. Les infections du système nerveux sont un problème

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POZZETTO, B., I. BECHRI, M. DELOLME, et al. "État des lieux du diagnostic virologique de l’infection à SARS-CoV-2." EXERCER 31, no. 163 (2020): 215–20. http://dx.doi.org/10.56746/exercer.2020.163.215.

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L’infection COVID-19 a émergé de façon soudaine en Chine, en décembre 2019 et est devenue rapidement pandémique. Le virus responsable a été identifié comme un nouveau coronavirus probablement issu d’un virus de chauve-souris, dénommé SARS-CoV-2, ce qui a permis de mettre au point des tests diagnostiques permettant l’identification de son ARN par techniques moléculaires. En plus du rappel de quelques données virologiques, l’objet de cette revue est de présenter les tests moléculaires de diagnostic direct et les tests sérologiques actuellement disponibles pour identifier cette infection. Le diag

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Delolme, M., Bruno Pozzetto, Josselin Rigaill, et al. "Les tests de diagnostic virologique de la Covid-19." Revue de biologie médicale 359, no. 2 (2021): 17–28. https://doi.org/10.3917/rbm.359.0017.

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L’infection Covid-19 a émergé soudainement dans la ville chinoise de Wuhan, en décembre 2019, et est devenue rapidement pandémique. Mi-janvier 2021, plus de 96 millions de cas confirmés sont survenus dans 218 pays ou territoires depuis son émergence un an auparavant, dont plus de 2 millions de cas mortels. Le virus responsable a été promptement identifié comme un nouveau coronavirus probablement issu d’un virus de chauve-souris, dénommé SARS-CoV-2, ce qui a permis de mettre au point des techniques permettant de le dépister. Le diagnostic repose principalement sur la détection du génome viral (

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Meunier, Nicolas. "Odorat et virus respiratoires :une relation révélée par la Covid-19." médecine/sciences 39, no. 2 (2023): 119–28. http://dx.doi.org/10.1051/medsci/2023007.

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L’odorat, sens pendant longtemps sous-estimé chez l’homme, a été mis sur le devant de la scène par sa soudaine disparition, survenue pendant la pandémie de Covid-19, dont l’anosmie est un des symptômes majeurs. Pourtant, depuis longtemps, les virus respiratoires ont été associés aux troubles de l’odorat, dont 25 % seraient liés à une infection virale. L’olfaction débute dans le nez, au sein d’un épithélium olfactif qui a la particularité de contenir des neurones en contact direct avec l’environnement. Plusieurs virus respiratoires sont connus pour leur capacité réplicative au sein de cet épith

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Stepanian, Alain, A. Ibos, Virginie Siguret, and Maxime Delrue. "Complications thromboemboliques lors de la première vague de COVID-19 : quels enseignements pratiques pour le biologiste médical ?" Revue de biologie médicale 363, no. 6 (2021): 7–17. https://doi.org/10.3917/rbm.363.0007.

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Le 31 décembre 2019, l’Organisation mondiale de la Santé (OMS) est informée de l’existence de cas de pneumonies virales d’étiologie inconnue détectés à Wuhan, dans la province du Hubei, en Chine. En quelques semaines, ce nouveau virus dénommé le SARS-CoV-2 ( severe acute respiratory syndrome coronavirus 2 ), responsable de la COVID-19 ( coronavirus disease 2019 ), a conduit à une pandémie d’une ampleur exceptionnelle. Si la maladie est le plus souvent bénigne, elle est responsable chez certains patients d’un syndrome de détresse respiratoire aiguё qui nécessite une prise en charge hospitalière

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Placinta, Gheorghe, Victor Pantea, Lilia Cojuhari, Valentin Cebotarescu, Lidia Placinta, and Dan Croitoru. "Interaction between SARS-CoV-2 and human organism." Moldovan Medical Journal 63(2) (May 30, 2020): 57–62. https://doi.org/10.5281/zenodo.3866031.

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<strong>Background: </strong>COVID-19 is a part of the betacoronaviridae group, sabercoviridae subgroup. At the moment we are confronting a pandemy, which has a completely new pathologic pattern for the whole world. Considering the highly contagious characteristics of the virus, which is the cause of death for many people, and also the fact that many people continue to be infected with this virus there is a stringing necesity of combating this pandemy. Because of that we need the knowledge that regards the physiopathologic mechanisms, particularities of the host-invader interactions, relevance

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Kubiak, Jacek Z., and Małgorzata Kloc. "Coronavirus Disease Pathophysiology: Biomarkers, Potential New Remedies, Comorbidities, Long COVID-19, Post Pandemic Epidemiological Surveillance." International Journal of Molecular Sciences 24, no. 15 (2023): 12236. http://dx.doi.org/10.3390/ijms241512236.

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8

Cespedes, Mateus da Silveira, and José Carlos Rosa Pires de Souza. "Sars-CoV-2: A clinical update - II." Revista da Associação Médica Brasileira 66, no. 4 (2020): 547–57. http://dx.doi.org/10.1590/1806-9282.66.4.547.

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SUMMARY INTRODUCTION A covid-19 pandemic decreed by WHO has raised greater awareness of it. EPIDEMIOLOGY The infection, reached the mark of 2,000,000 patients in 33 countries and caused the risk of the presence of comorbidities and advanced age. TRANSMISSIBILITY The transmissibility calculated so far is similar to the H1N1 epidemic, but with lower mortality rates. PHYSIOPATHOLOGY The SARS-CoV-2 virus, of the Coronaviridae family, has the capacity for cellular invasion through the angiotensin-converting enzyme 2 does not have a lower respiratory epithelium and in the cells of the small intestin

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Enache, Alexandra, Veronica Ciocan, Camelia Oana Muresan, et al. "Postmortem Documentation of SARS-CoV-2 in Utero and Postpartum Transmission, through Amniotic Fluid, Placental, and Pulmonary Tissue RT-PCR." Applied Sciences 11, no. 20 (2021): 9505. http://dx.doi.org/10.3390/app11209505.

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The physiopathology of SARS-CoV-2 infection, during pregnancy and in early childhood, is poorly understood. Unfavorable maternal outcomes, the risk of vertical/postpartum transmission, and severe, multisystem involvement in infants and children highlight the importance of developing a cohesive treatment and nuanced prophylaxis strategy. In this study, we evaluate autopsy reports, pathological findings, and SARS-CoV-2 genome expression in three distinct clinical scenarios: maternal death due to severe COVID-19 with in utero fetal demise (27 weeks); mother with moderate COVID-19 and in utero fet

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Patiño-Rodríguez, Hernán Mauricio, Angie Viviana Parra-Guacaneme, Caludia Marcela Moreno-Rodríguez, Cesar Daniel Torres-López, and Jaren Lorena Horta-Garavito. "Non-catastrophic Deep Cerebral Vein Thrombosis in COVID-19: Case report." ICTUS 2, no. 1 (2021): e07012102010. https://doi.org/10.5281/zenodo.4428972.

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<strong>Introduction</strong>. SARS-CoV-2 infection responsible for COVID-19, has demonstrated neurotropic and neuroinvasive potential, displaying several neurological manifestations ranging from mild to severe complications, the latter related to a prothrombotic state, giving place to stroke and less often cerebral venous thrombosis. The physiopathology of these events is currently elucidated from various mechanisms including thrombo-inflammation, endotheliopathy, and stasis in critically ill patients. <strong>Case Report.</strong> We present the case of a 48-year-old woman that develops cere

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Sacramento, Carolina Q., Natalia Fintelman-Rodrigues, Suelen S. G. Dias, et al. "Unlike Chloroquine, Mefloquine Inhibits SARS-CoV-2 Infection in Physiologically Relevant Cells." Viruses 14, no. 2 (2022): 374. http://dx.doi.org/10.3390/v14020374.

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Despite the development of specific therapies against severe acute respiratory coronavirus 2 (SARS-CoV-2), the continuous investigation of the mechanism of action of clinically approved drugs could provide new information on the druggable steps of virus–host interaction. For example, chloroquine (CQ)/hydroxychloroquine (HCQ) lacks in vitro activity against SARS-CoV-2 in TMPRSS2-expressing cells, such as human pneumocyte cell line Calu-3, and likewise, failed to show clinical benefit in the Solidarity and Recovery clinical trials. Another antimalarial drug, mefloquine, which is not a 4-aminoqui

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Lansiaux, Edouard, Emmanuel Drouin, and Carsten Bolm. "Beta-Thalassemia Minor and SARS-CoV-2: Physiopathology, Prevalence, Severity, Morbidity, and Mortality." Thalassemia Reports 13, no. 1 (2023): 21–32. http://dx.doi.org/10.3390/thalassrep13010003.

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Background: Since the first year of the COVID-19 global pandemic, a hypothesis concerning the possible protection/immunity of beta-thalassemia carriers has remained in abeyance. Methods: Three databases (Pubmed Central, Scopus, and Google Scholar) were screened and checked in order to extract all studies about the incidence of confirmed COVID-19 cases, mortality rate, severity assessment, or ICU admission among patients with beta-thalassemia minor, were included in this analysis. The language was limited to English. Studies such as case reports, review studies, and studies that did not have co

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Lazar, Mihai, Mihai Sandulescu, Ecaterina Constanta Barbu, et al. "The Role of Cytokines and Molecular Pathways in Lung Fibrosis Following SARS-CoV-2 Infection: A Physiopathologic (Re)view." Biomedicines 12, no. 3 (2024): 639. http://dx.doi.org/10.3390/biomedicines12030639.

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SARS-CoV-2 infection is a significant health concern that needs to be addressed not only during the initial phase of infection but also after hospitalization. This is the consequence of the various pathologies associated with long COVID-19, which are still being studied and researched. Lung fibrosis is an important complication after COVID-19, found in up to 71% of patients after discharge. Our research is based on scientific articles indexed in PubMed; in the selection process, we used the following keywords: “lung fibrosis”, “fibrosis mediators”, “fibrosis predictors”, “COVID-19”, “SARS-CoV-

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Sebastián-Martín, Alba, Belén G. Sánchez, José M. Mora-Rodríguez, Alicia Bort, and Inés Díaz-Laviada. "Role of Dipeptidyl Peptidase-4 (DPP4) on COVID-19 Physiopathology." Biomedicines 10, no. 8 (2022): 2026. http://dx.doi.org/10.3390/biomedicines10082026.

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DPP4/CD26 is a single-pass transmembrane protein with multiple functions on glycemic control, cell migration and proliferation, and the immune system, among others. It has recently acquired an especial relevance due to the possibility to act as a receptor or co-receptor for SARS-CoV-2, as it has been already demonstrated for other coronaviruses. In this review, we analyze the evidence for the role of DPP4 on COVID-19 risk and clinical outcome, and its contribution to COVID-19 physiopathology. Due to the pathogenetic links between COVID-19 and diabetes mellitus and the hyperinflammatory respons

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Singh, Preeti, and Biplob Adhikari. "Journey of SARS-CoV-19 from Mucosa Towards Angiotensin-Converting Enzyme2 Pathway: A Review." Journal of Nepalese Society of Periodontology and Oral Implantology 5, no. 2 (2021): 92–96. http://dx.doi.org/10.3126/jnspoi.v5i2.52980.

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The disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) or simply corona virus disease-2019 (COVID-19), has rapidly spread throughout the world. World Health Organization declared a global health emergency on January 30, 2020 announcing it as a Pandemic. The outbreak of the disease has posed serious health threat. A search was conducted for review which included various articles from 2019 to 2021 in PubMed/MEDLINE with keywords ACE2, 2019 NCOV, pandemic, physiopathology, SARS, Transmission. Both humoral and acquired immunity are targeted by the virus during progressi

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Gaujac, Cristiano, and Regiane Cristina Amaral. "Neurological manifestations and pathophysiological mechanisms of Covid-19." ARCHIVES OF HEALTH INVESTIGATION 10, no. 7 (2021): 1040–47. http://dx.doi.org/10.21270/archi.v10i7.5460.

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Background - Severe acute respiratory syndrome coronavirus-2 is a novel, highly infectious coronavirus and the etiologic agent of Covid-19. The course of Covid-19 can range from mild flu-like symptoms to severe, life-threatening symptoms, especially when comorbidities are present. Increasing studies have reinforced the association between SARS-CoV-2 and various neurological manifestations, although the pathophysiological mechanisms remain uncertain. Objective - The aim of this paper was to briefly describe current findings on the relationship between SARS-CoV-2 pathophysiology and major CNS an

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Pacnejer, Aliteia-Maria, Anca Butuca, Carmen Maximiliana Dobrea, et al. "Neuropsychiatric Burden of SARS-CoV-2: A Review of Its Physiopathology, Underlying Mechanisms, and Management Strategies." Viruses 16, no. 12 (2024): 1811. http://dx.doi.org/10.3390/v16121811.

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The COVID-19 outbreak, caused by the SARS-CoV-2 virus, was linked to significant neurological and psychiatric manifestations. This review examines the physiopathological mechanisms underlying these neuropsychiatric outcomes and discusses current management strategies. Primarily a respiratory disease, COVID-19 frequently leads to neurological issues, including cephalalgia and migraines, loss of sensory perception, cerebrovascular accidents, and neurological impairment such as encephalopathy. Lasting neuropsychological effects have also been recorded in individuals following SARS-CoV-2 infection

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Zota, Ioana Mădălina, Cristian Stătescu, Radu Andy Sascău, et al. "Acute and Long-Term Consequences of COVID-19 on Arterial Stiffness—A Narrative Review." Life 12, no. 6 (2022): 781. http://dx.doi.org/10.3390/life12060781.

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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the ongoing global coronavirus (COVID-19) pandemic. Although initially viewed as an acute respiratory illness, COVID-19 is clearly a complex multisystemic disease with extensive cardiovascular involvement. Emerging evidence shows that the endothelium plays multiple roles in COVID-19 physiopathology, as both a target organ that can be directly infected by SARS-CoV-2 and a mediator in the subsequent inflammatory and thrombotic cascades. Arterial stiffness is an established marker of cardiovascular disease. The sc

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González-Villalva, Adriana, Aurora de la Peña-Díaz, Marcela Rojas-Lemus, et al. "Fisiología de la hemostasia y su alteración por la coagulopatía en COVID-19." Revista de la Facultad de Medicina 63, no. 5 (2020): 45–57. http://dx.doi.org/10.22201/fm.24484865e.2020.63.5.08.

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COVID-19 global pandemic caused by Sars-CoV-2 virus, has worried to health care providers due to the high mortality rate related to coagulopathy in many patients. COVID-19 coagulopathy is mainly thrombotic, first locally in lungs but later on it becomes micro and macrovascular systemic coagulopathy. It has been associated to endothelial damage, inflammation, neutrophil-extracellular traps, monocyte and macrophage activation, cytokines storm that induce a vicious cycle of thrombosis and inflammation. The increased levels of prothrombotic factors as tissue factor, Von Willebrand factor, fibrinog

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Scarcella, Antonio, Maria Vincenza Mastrolia, Edoardo Marrani, Ilaria Maccora, Ilaria Pagnini, and Gabriele Simonini. "Neuro-PIMS-TS: a single case report and review of the literature." Therapeutic Advances in Musculoskeletal Disease 14 (January 2022): 1759720X2211396. http://dx.doi.org/10.1177/1759720x221139627.

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Neurological manifestations related to SARS-CoV-2 infection in adults have been largely reported since the beginning of the pandemic. Subsequent large-scale studies involving children confirmed the occurrence of neurological symptoms associated with SARS-CoV-2 infection also among paediatric patients, especially in the context of paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS). At this regard, we report the challenging case of a 10-month-old baby with PIMS-TS complicated by acute cerebral oedema successfully treated with intravenous immunoglobulins, c

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Méndez-García, Lucía Angélica, Helena Solleiro-Villavicencio, Sebastián Guartazaca-Guerrero, Jahir Rodríguez-Morales, and José Damián Carrillo-Ruiz. "Neurological Diseases Define the Cytokine Profile in CFS during SARS-CoV-2 Infection in Highly Ill Patients." Tropical Medicine and Infectious Disease 8, no. 6 (2023): 290. http://dx.doi.org/10.3390/tropicalmed8060290.

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Neuroinflammation is critical in developing and progressing neurological diseases. The underlying pro-inflammatory cytokine expression combined with additional mechanisms in the neuropathology, such as oxidative stress, brain–blood barrier damage, and endothelial dysfunction, could contribute to the susceptibility to developing severe COVID-19. The physiopathology of SARS-CoV-2 and other human coronaviruses (H-CoVs) has not been completely understood; however, they have all been linked to a disproportionated response of the immune system, particularly an exacerbated cytokine production and the

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Zarrilli, Giovanni, Valentina Angerilli, Gianluca Businello, et al. "The Immunopathological and Histological Landscape of COVID-19-Mediated Lung Injury." International Journal of Molecular Sciences 22, no. 2 (2021): 974. http://dx.doi.org/10.3390/ijms22020974.

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A complete understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) physiopathology and related histopathologic lesions is necessary to improve treatment and outcome of coronavirus disease 2019 (COVID-19) patients. Many studies have focused on autopsy findings in COVID-19-related deaths to try and define any possible specific pattern. Histopathologic alterations are principally found within lungs and blood vessels, and these abnormalities also seem to have the highest clinical impact. Nevertheless, many of the morphological data collected so far are non-specific, fickle, a

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Amália, Cinthia Meneses do Rêgo, and Araújo-Filho Irami. "Long COVID and lung thromboembolism in young adults." World Journal of Advanced Research and Reviews 23, no. 1 (2024): 3030–37. https://doi.org/10.5281/zenodo.14830623.

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Long-term COVID-19 (Long COVID) and pulmonary thromboembolism (PTE) significantly challenge healthcare, especially in young adults who are typically at lower risk for such severe outcomes. This review explores the complex relationship between long-term COVID and PTE, focusing on the pathophysiological mechanisms, diagnostic challenges, and therapeutic approaches. Persistent inflammation and immune dysregulation associated with long-term COVID-19 contribute to this demographic's increased thrombotic risk. The symptom overlaps between long-term COVID and PTE complicate the accuracy and timelines

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Evangelista, Heitor, César Amaral, Luís Cristóvão Porto, et al. "Modeling the initial phase of SARS-CoV-2 deposition in the respiratory tract mimicked by the 11C radionuclide." PLOS ONE 16, no. 1 (2021): e0245019. http://dx.doi.org/10.1371/journal.pone.0245019.

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The knowledge on the deposition and retention of the viral particle of SARS-CoV-2 in the respiratory tract during the very initial intake from the ambient air is of prime importance to understand the infectious process and COVID-19 initial symptoms. We propose to use a modified version of a widely tested lung deposition model developed by the ICRP, in the context of the ICRP Publication 66, that provides deposition patterns of microparticles in different lung compartments. In the model, we mimicked the "environmental decay" of the virus, determined by controlled experiments related to normal s

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Chaturvedi, Pragya, and Sudhanshu Singh. "Significance of Epigenetics in Sars-CoV-2 Infection and Proposed Epi-Drugs for Covid-19." SAMRIDDHI : A Journal of Physical Sciences, Engineering and Technology 13, SUP 1 (2021): 21–26. http://dx.doi.org/10.18090/samriddhi.v13is1.6.

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We frequently come in contact with animal viruses through the food which we eat, the pets which we have, and our connections with nature. The enormous majority of viruses which enter our bodies pass inoffensively through our physiological systems or eradicate by our immune systems. However, on rare circumstances, a human-encounters by a virus which begins to replicate itself, accomplishing its entire lifecycle within human cells and intensifying themselves into a large number. Replication of an animal virus inside the human body is the key instant in the zoonotic process. SARS CoV-2 is one of

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Lopes, Luiz Thiago Oliveira, Marcelus de Andrade Oliveira, Willian Guilherme Lobato Gonçalves, et al. "Séquelles de la COVID-19 : revue intégrative de la littérature." Núcleo do Conhecimento 01, no. 08 (2023): 68–87. https://doi.org/10.32749/nucleodoconhecimento.com.br/sante/sequelles-de-la-covid.

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La grande affinité entre la protéine Spike du virus SARS-CoV-2 et le récepteur de l'enzyme de conversion de l'angiotensine 2 est postulée comme l'une des principales raisons de la forte taux de transmission virale, ce qui a conduit l'OMS à déclarer la COVID-19 comme une Urgence de Santé Publique d'Intérêt International, ainsi qu'à adopter des mesures de contenances de la propagation virale. De plus, grâce au mécanisme physiopathologique du virus, on observe généralement des symptômes non spécifiques, une évolution atypique, principalement chez les personnes âgées et immunodéprimées, ainsi qu'u

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Sanchez, Belén G., Jose M. Gasalla, Manuel Sánchez-Chapado, Alicia Bort, and Inés Diaz-Laviada. "Increase in Ischemia-Modified Albumin and Pregnancy-Associated Plasma Protein-A in COVID-19 Patients." Journal of Clinical Medicine 10, no. 23 (2021): 5474. http://dx.doi.org/10.3390/jcm10235474.

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This study was undertaken due to the urgent need to explore reliable biomarkers for early SARS-CoV-2 infection. We performed a retrospective study analyzing the serum levels of the cardiovascular biomarkers IL-6, TNF-α, N-terminal pro-B natriuretic peptide, cardiac troponin T (cTnT), ischemia-modified albumin (IMA) and pregnancy-associated plasma protein-A (PAPP-A) in 84 patients with COVID-19.Patients were divided into three groups according to their RT-qPCR and IgG values: acute infection (n = 35), early infection (n = 25) or control subjects (n = 24). Levels of biomarkers were analyzed in p

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Moatar, Alexandra Ioana, Aimee Rodica Chis, Catalin Marian, and Ioan-Ovidiu Sirbu. "Gene Network Analysis of the Transcriptome Impact of SARS-CoV-2 Interacting MicroRNAs in COVID-19 Disease." International Journal of Molecular Sciences 23, no. 16 (2022): 9239. http://dx.doi.org/10.3390/ijms23169239.

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According to the World Health Organization (WHO), as of June 2022, over 536 million confirmed COVID-19 disease cases and over 6.3 million deaths had been globally reported. COVID-19 is a multiorgan disease involving multiple intricated pathological mechanisms translated into clinical, biochemical, and molecular changes, including microRNAs. MicroRNAs are essential post-transcriptional regulators of gene expression, being involved in the modulation of most biological processes. In this study, we characterized the biological impact of SARS-CoV-2 interacting microRNAs differentially expressed in

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Barbosa, Adriana Aparecida de Oliveira, Gabriel Cunha Beato, Pietra Antônia Filiol Belin, and Larissa Ramos Araújo. "ASPECTOS CLÍNICOS DA MÁ NUTRIÇÃO NA COVID-19." Simbio-Logias Revista Eletrônica de Educação Filosofia e Nutrição 12, no. 16 (2020): 01–19. http://dx.doi.org/10.32905/19833253.2020.12.16p01.

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The pandemic caused by the new coronavirus has sparked discussions among health professionals about the role of food and nutrition in the infectious condition caused by the SARS-CoV-2 virus in different population groups. Malnutrition, including obesity, may reflect more severe outcomes in the physiopathology of infection and systemic responses caused by COVID-19. The present work aims to make considerations directed to the nutritionist about the susceptibility of COVID-19 in individuals submitted to malnutrition, highlighting possible outcomes of the disease and the importance of nutritional

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Franczuk, Monika, Tadeusz Przybyłowski, Małgorzata Czajkowska-Malinowska, et al. "Spirometry during the SARS-CoV-2 pandemic. Guidelines and practical advice from the expert panel of Respiratory Physiopathology Assembly of Polish Respiratory Society." Advances in Respiratory Medicine 88, no. 6 (2020): 640–50. http://dx.doi.org/10.5603/arm.a2020.0186.

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Cespedes, Mateus da Silveira, and José Carlos Rosa Pires de Souza. "Coronavirus: a clinical update of Covid-19." Revista da Associação Médica Brasileira 66, no. 2 (2020): 116–23. http://dx.doi.org/10.1590/1806-9282.66.2.116.

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SUMMARY INTRODUCTION A covid-19 pandemic decreed by WHO has raised greater awareness of it. EPIDEMIOLOGY The infection reached the mark of 350,000 patients in 33 countries and affected as comorbidities the presence of comorbidities and advanced age. TRANSMISSIBILITY The transmissibility calculated so far is similar to the H1N1 epidemic, but with lower mortality rates. PHYSIOPATHOLOGY The SARS-CoV-2 virus, of the Coronaviridae family, has the capacity for cellular invasion through the angiotensin-converting enzyme 2 does not have a lower respiratory epithelium and in the cells of the small inte

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Frías-De-León, María Guadalupe, Rodolfo Pinto-Almazán, Rigoberto Hernández-Castro, et al. "Epidemiology of Systemic Mycoses in the COVID-19 Pandemic." Journal of Fungi 7, no. 7 (2021): 556. http://dx.doi.org/10.3390/jof7070556.

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The physiopathologic characteristics of COVID-19 (high levels of inflammatory cytokines and T-cell reduction) promote fungal colonization and infection, which can go unnoticed because the symptoms in both diseases are very similar. The objective of this work was to study the current epidemiology of systemic mycosis in COVID-19 times. A literature search on the subject (January 2020–February 2021) was performed in PubMed, Embase, Cochrane Library, and LILACS without language restrictions. Demographic data, etiological agent, risk factors, diagnostic methods, antifungal treatment, and fatality r

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Laste, Gabriela, and Jorge de Oliveira Mateus. "Coronavirus in Pregnancy: The Role of Melatonin." Journal of Advances in Medicine and Medical Research 36, no. 2 (2024): 97–112. http://dx.doi.org/10.9734/jammr/2024/v36i25371.

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The effects of COVID-19 on pregnant individuals are unclear due to a series of physiological changes and immune system adaptations that may affect the development of the fetus. There is evidence supporting the role of melatonin in human pregnancy, and it appears that melatonin is essential for a successful pregnancy. However, in pathological conditions, such as during SARS-CoV-2 infection, melatonin levels can be significantly inhibited. In addition, melatonin, a powerful endogen antioxidant, free radical scavenger, and anti-inflammatory molecule, has been reported to exert beneficial effects

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Ciorba, Andrea, Stavros Hatzopoulos, Cristina Cogliandolo, et al. "Functional Magnetic Resonance Imaging in the Olfactory Perception of the Same Stimuli." Life 11, no. 1 (2020): 11. http://dx.doi.org/10.3390/life11010011.

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Background. Data in the literature report that a number of studies have attempted to identify the exact location of the cortical olfaction representation, searching for evidence suggesting that sniffing odors can initiate a primary activation of the piriform cortex and the insula. Nowadays, due to the SARS-CoV-2 (COVID-19) outbreak, the functional study of the olfactory system could offer a better understanding of the physiopathology of olfactory perception, elucidating better the possible site(s) of damage induced by the COVID-19 infection. The aim of this paper was to evaluate brain maps gen

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Humphries, Matthew Phillip, Victoria Bingham, Fatima Abdullah Sidi, et al. "Technical note on the exploration of COVID-19 in autopsy material." Journal of Clinical Pathology, January 30, 2023, jcp—2022–208525. http://dx.doi.org/10.1136/jcp-2022-208525.

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Interrogation of immune response in autopsy material from patients with SARS-CoV-2 is potentially significant. We aim to describe a validated protocol for the exploration of the molecular physiopathology of SARS-CoV-2 pulmonary disease using multiplex immunofluorescence (mIF).The application of validated assays for the detection of SARS-CoV-2 in tissues, originally developed in our laboratory in the context of oncology, was used to map the topography and complexity of the adaptive immune response at protein and mRNA levels.SARS-CoV-2 is detectable in situ by protein or mRNA, with a sensitivity

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Teixeira, Lívia, Jairo R. Temerozo, Filipe S. Pereira-Dutra, et al. "Simvastatin Downregulates the SARS-CoV-2-Induced Inflammatory Response and Impairs Viral Infection Through Disruption of Lipid Rafts." Frontiers in Immunology 13 (February 18, 2022). http://dx.doi.org/10.3389/fimmu.2022.820131.

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Coronavirus disease 2019 (COVID-19) is currently a worldwide emergency caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). In observational clinical studies, statins have been identified as beneficial to hospitalized patients with COVID-19. However, experimental evidence of underlying statins protection against SARS-CoV-2 remains elusive. Here we reported for the first-time experimental evidence of the protective effects of simvastatin treatment both in vitro and in vivo. We found that treatment with simvastatin significantly reduced the viral replication and lung damage in

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Devaux, Christian A., Jean-Christophe Lagier, and Didier Raoult. "New Insights Into the Physiopathology of COVID-19: SARS-CoV-2-Associated Gastrointestinal Illness." Frontiers in Medicine 8 (February 18, 2021). http://dx.doi.org/10.3389/fmed.2021.640073.

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Although SARS-CoV-2 is considered a lung-tropic virus that infects the respiratory tract through binding to the ACE2 cell-surface molecules present on alveolar lungs epithelial cells, gastrointestinal symptoms have been frequently reported in COVID-19 patients. What can be considered an apparent paradox is that these symptoms (e.g., diarrhea), sometimes precede the development of respiratory tract illness as if the breathing apparatus was not its first target during viral dissemination. Recently, evidence was reported that the gut is an active site of replication for SARS-CoV-2. This replicati

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Piotrowicz, Karolina, Jerzy Gąsowski, Jean-Pierre Michel, and Nicola Veronese. "Post-COVID-19 acute sarcopenia: physiopathology and management." Aging Clinical and Experimental Research, July 30, 2021. http://dx.doi.org/10.1007/s40520-021-01942-8.

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AbstractIn this review, we discuss the pathophysiologic and management aspects of acute sarcopenia in relation to SARS-CoV-2 infection. COVID-19 is as a multi-organ infectious disease characterized by a severe inflammatory and highly catabolic status, influencing the deep changes in the body build, especially the amount, structure, and function of skeletal muscles which would amount to acutely developed sarcopenia. Acute sarcopenia may largely impact patients’ in-hospital prognosis as well as the vulnerability to the post-COVID-19 functional and physical deterioration. The individual outcome o

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Martin-Cardona, Albert, Josep Lloreta Trull, Raquel Albero-González, et al. "SARS-CoV-2 identified by transmission electron microscopy in lymphoproliferative and ischaemic intestinal lesions of COVID-19 patients with acute abdominal pain: two case reports." BMC Gastroenterology 21, no. 1 (2021). http://dx.doi.org/10.1186/s12876-021-01905-3.

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Abstract Background SARS-CoV-2 may produce intestinal symptoms that are generally mild, with a small percentage of patients developing more severe symptoms. The involvement of SARS-CoV-2 in the physiopathology of bowel damage is poorly known. Transmission electron microscopy (TEM) is a useful tool that provides an understanding of SARS-CoV-2 invasiveness, replication and dissemination in body cells but information outside the respiratory tract is very limited. We report two cases of severe intestinal complications (intestinal lymphoma and ischaemic colitis) in which the presence of SARS-CoV-2

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Monchatre-Leroy, Elodie, Sandrine Lesellier, Marine Wasniewski, et al. "Hamster and ferret experimental infection with intranasal low dose of a single strain of SARS-CoV-2." Journal of General Virology 102, no. 3 (2021). http://dx.doi.org/10.1099/jgv.0.001567.

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Understanding the pathogenesis of the SARS-CoV-2 infection is key to developing preventive and therapeutic strategies against COVID-19, in the case of severe illness but also when the disease is mild. The use of appropriate experimental animal models remains central in the in vivo exploration of the physiopathology of infection and antiviral strategies. This study describes SARS-CoV-2 intranasal infection in ferrets and hamsters with low doses of low-passage SARS-CoV-2 clinical French isolate UCN19, describing infection levels, excretion, immune responses and pathological patterns in both anim

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Bourial, Abderrahim, Wahib Lahlou, Mounir Rghioui, Sidi Mamoun Louraoui, Abdessamad El Azhari, and Fadila Guessous. "An Exceptional Case of a Supra-tentorial Streptococcus Salivarius Brain Abscess—A Case Report." Clinical Medicine Insights: Case Reports 18 (March 2025). https://doi.org/10.1177/11795476251325803.

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Introduction: During the COVID-19 pandemic, incidence of brain abscesses is difficult to assess. Numerous studies reported benign and severe post SARS-CoV-2 vaccine side effects, including rare cases of brain abscesses associated with COVID-19 or Anti-SARS-CoV-2 vaccines. Here in, we report what we believe to be, up to date, the fourth known case in the medical literature of a streptococcus salivarius brain abscess, the first intra parenchymatous or supra-tentorial streptococcus salivarius brain abscess and also the first that occurs following an anti-SARS-CoV-2 vaccine. Case presentation: We

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Zazzara, Maria Beatrice, Anna Modoni, Alessandra Bizzarro, et al. "COVID-19 atypical Parsonage-Turner syndrome: a case report." BMC Neurology 22, no. 1 (2022). http://dx.doi.org/10.1186/s12883-022-02622-4.

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Abstract Background Neurological manifestations of Sars-CoV-2 infection have been described since March 2020 and include both central and peripheral nervous system manifestations. Neurological symptoms, such as headache or persistent loss of smell and taste, have also been documented in COVID-19 long-haulers. Moreover, long lasting fatigue, mild cognitive impairment and sleep disorders appear to be frequent long term neurological manifestations after hospitalization due to COVID-19. Less is known in relation to peripheral nerve injury related to Sars-CoV-2 infection. Case presentation We repor

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Lucas, de Alencar Viana Melo, Matias Neto Wantuil, and Leite Rolim Neto Modesto. "Cardiovascular System and SARS-COV-2 – Etiology, Physiopathology and Clinical Presentation: a Systematic Review." Health Science Journal 15, no. 06 (2024). https://doi.org/10.36648/1791-809X.21.15.845.

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Valdez-Cruz, Norma A., Enrique García-Hernández, Clara Espitia, et al. "Integrative overview of antibodies against SARS-CoV-2 and their possible applications in COVID-19 prophylaxis and treatment." Microbial Cell Factories 20, no. 1 (2021). http://dx.doi.org/10.1186/s12934-021-01576-5.

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AbstractSARS-CoV-2 is a novel β-coronavirus that caused the COVID-19 pandemic disease, which spread rapidly, infecting more than 134 million people, and killing almost 2.9 million thus far. Based on the urgent need for therapeutic and prophylactic strategies, the identification and characterization of antibodies has been accelerated, since they have been fundamental in treating other viral diseases. Here, we summarized in an integrative manner the present understanding of the immune response and physiopathology caused by SARS-CoV-2, including the activation of the humoral immune response in SA

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Cezar, Renaud, Lucy Kundura, Sonia André, et al. "T4 apoptosis in the acute phase of SARS-CoV-2 infection predicts long COVID." Frontiers in Immunology 14 (January 3, 2024). http://dx.doi.org/10.3389/fimmu.2023.1335352.

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BackgroundAs about 10% of patients with COVID-19 present sequelae, it is important to better understand the physiopathology of so-called long COVID.MethodTo this aim, we recruited 29 patients hospitalized for SARS-CoV-2 infection and, by Luminex®, quantified 19 soluble factors in their plasma and in the supernatant of their peripheral blood mononuclear cells, including inflammatory and anti-inflammatory cytokines and chemokines, Th1/Th2/Th17 cytokines, and endothelium activation markers. We also measured their T4, T8 and NK differentiation, activation, exhaustion and senescence, T cell apoptos

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Pagano, S., S. Yerly, N. Suh, et al. "Sars-CoV2- infection as a trigger of humoral response against apolipoprotein A-1." European Heart Journal 42, Supplement_1 (2021). http://dx.doi.org/10.1093/eurheartj/ehab724.2757.

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Abstract Background Unravelling autoimmune targets triggered by SARS-CoV-2 infection may provide crucial insights in the physiopathology of the disease and foster the development of potential therapeutic candidate targets and prognostic tools. SARS-CoV-2 autoimmune-mediated inflammation have been reported, but the existence of autoantibodies against apolipoprotein A-1 (anti-apoA-1 IgG) in COVID-19 remains unexplored. Anti-apoA-1 IgGs have emerged as an independent biomarker for cardiovascular disease and mortality in humans with proinflammatory and proatherogenic functions in vivo and in vitro

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Valdés, José, Fernando Vivanco, Marianella Hernández, and Lorna Galleguillos. "COVID-19 Related Encephalopathy." Medical Research Archives 10, no. 12 (2022). http://dx.doi.org/10.18103/mra.v10i12.3462.

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SARS-CoV-2 infection can present with neurological symptoms due to direct or indirect invasion of the central nervous system. There are many hypotheses of why this happens, focusing on systemic inflammation, cytokines and cells, but none of them are completely understood. We present a case of a 66-year-old female that presented with a severe encephalopathy during her COVID-19 infection. We discuss physiopathology, risk factors, work up, possible treatments according to the physiopathological damage and prognosis according to the treatment response.

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Devaux, Christian A., and Laurence Camoin-Jau. "An update on angiotensin-converting enzyme 2 structure/functions, polymorphism, and duplicitous nature in the pathophysiology of coronavirus disease 2019: Implications for vascular and coagulation disease associated with severe acute respiratory syndrome coronavirus infection." Frontiers in Microbiology 13 (November 28, 2022). http://dx.doi.org/10.3389/fmicb.2022.1042200.

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It has been known for many years that the angiotensin-converting enzyme 2 (ACE2) is a cell surface enzyme involved in the regulation of blood pressure. More recently, it was proven that the severe acute respiratory syndrome coronavirus (SARS-CoV-2) interacts with ACE2 to enter susceptible human cells. This functional duality of ACE2 tends to explain why this molecule plays such an important role in the clinical manifestations of coronavirus disease 2019 (COVID-19). At the very start of the pandemic, a publication from our Institute (entitled “ACE2 receptor polymorphism: susceptibility to SARS-

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Bracaccia, Maria Elena, Nicolò De Cicco, Alessandra Moioli, Simona Barberi, Claudia Fofi, and Paolo Mene'. "MO240A FATAL CASE OF VASCULITIS AFTER SARS-COV-2 NEGATIVIZATION." Nephrology Dialysis Transplantation 36, Supplement_1 (2021). http://dx.doi.org/10.1093/ndt/gfab092.00118.

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Abstract Background and Aims Spectrum of acute severe respiratory syndrome Coronavirus 2 (SARS-CoV-2) ranges from mild to critical and probably mortality rate is largely underestimated. Complications may represent different manifestation of a profound endothelial dysfunction and injury. Biopsies reveal macro and microvascular thrombosis involving larger and smaller vessels. Different Authors described accumulation of inflammatory cells across vascular bed, viral inclusions and apoptotic bodies across vascular bed. Endotheliitis leads to loss of vessel integrity with bleedings and lumen restric

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Oliviero, Antonio, Fernando de Castro, Francesca Coperchini, Luca Chiovato, and Mario Rotondi. "COVID-19 Pulmonary and Olfactory Dysfunctions: Is the Chemokine CXCL10 the Common Denominator?" Neuroscientist, July 13, 2020, 107385842093903. http://dx.doi.org/10.1177/1073858420939033.

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COVID-19 is an ongoing viral pandemic that emerged from East Asia and quickly spread to the rest of the world. SARS-CoV-2 is the virus causing COVID-19. Acute respiratory distress syndrome (ARDS) is definitely one of the main clinically relevant consequences in patients with COVID-19. Starting from the earliest reports of the COVID-19 pandemic, two peculiar neurological manifestations (namely, hyposmia/anosmia and dysgeusia) were reported in a relevant proportion of patients infected by SARS-CoV-2. At present, the physiopathologic mechanisms accounting for the onset of these symptoms are not y

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