Relevant bibliographies by topics / SBF bioactivity / Journal articles
To see the other types of publications on this topic, follow the link: SBF bioactivity.

Journal articles on the topic 'SBF bioactivity'

Author: Grafiati
Published: 4 June 2021
Last updated: 17 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'SBF bioactivity.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

López, Haydée Y., Dora A. Cortés-Hernández, Sergio Escobedo, and D. Mantovani. "In Vitro Bioactivity Assessment of Metallic Magnesium." Key Engineering Materials 309-311 (May 2006): 453–56. http://dx.doi.org/10.4028/www.scientific.net/kem.309-311.453.

Full text
Abstract:
In the aim to decrease the degradation rate of magnesium in simulated body fluid, pure magnesium was treated by two different routes, i) by soaking specimens in an HF aqueous solution at 30oC for 30 min and ii) by heating specimens at 345oC for 15 min. The treated samples were immersed in simulated body fluid (SBF) at 37oC for different periods of time. Samples with no treatment were also immersed in SBF. The magnesium released into the SBF, the weight loss of the specimens and the pH of SBF increased with time of immersion in all the cases. The heat treated samples showed a lower degradation rate and lower pH values. A substantial decrease of magnesium concentration in the SBF corresponding to the heat treated samples was also observed. However, the degradation rate of the heat treated samples remains being extremely high. On the other hand, a bonelike apatite layer was observed after only 3 days of immersion in SBF in all the cases. The thickness of this layer increased with time of immersion. Further research needs to be performed to decrease the degradation rate. However, these results indicate that magnesium is a highly potential bioactive material for biomedical applications.
APA, Harvard, Vancouver, ISO, and other styles
2

Łączka, Maria, Ewelina Maślanka, Justyna Pawlik, Michał Dziadek, Barbara Zagrajczuk, and Katarzyna Cholewa-Kowalska. "Bioactivity of PLGA-gel-derived bioglass composites." Science, Technology and Innovation 3, no. 2 (December 27, 2018): 27–34. http://dx.doi.org/10.5604/01.3001.0012.8153.

Full text
Abstract:
A series of PLGA (poly L-lactide-co-glycolide) based composites modified with gel-derived glasses in the form of foils were obtained by solvent casting procedure. As a modifier, glass particles with different chemical compositions from the CaO–SiO2, CaO–P2O5–SiO2, and Al2O3–SiO2 systems were used. All glasses were synthesized by the sol-gel process. Evaluation of bioactive properties of obtained composites was made on the basis of surface changes occurring during contact with simulated body fluid. The changes of Ca, P and Si ions concentration in SBF after incubation of composites were also measured. The result showed that all composites with bioglasses (CaO–SiO2, CaO–P2O5–SiO2) exhibit formation of calcium phosphates layer after SBF test, however, kinetics of Ca, Si ion release and P uptake from SBF was dependent on bioglass chemical composition. The higher solubility, as well as faster consumption of phosphorus from SBF, was observed for materials from CaO–SiO2 (T1/PLGA, S1/PLGA) compared to composites with respective bioglass particles from the CaO–P2O5–SiO2(T2/PLGA, S2/PLGA). Our results showed that rate of Si and Ca release from the gel-derived glasses and P uptake from SBF are dependent on both: the concentration of respective ions in the materials and the presence of phosphates in their structure. For materials modified with gel-derived glasses from Al2O3–SiO2 system no significant surface changes during contact with SBF were observed, and it seems that their behavior in physiological solution indicate that they are bio-inert materials.
APA, Harvard, Vancouver, ISO, and other styles
3

Amaoka, Emiko, Erik Vedel, Satoshi Nakamura, Yusuke Moriyoshi, Jukka I. Salonen, and Kimihiro Yamashita. "Effect of Electrical Polarization on the Behavior of Bioactive Glass Containing MgO and B2O3 in SBF." Key Engineering Materials 309-311 (May 2006): 333–36. http://dx.doi.org/10.4028/www.scientific.net/kem.309-311.333.

Full text
Abstract:
We investigated the electrical polarizability of MgO and B2O3 containing bioactive glass (MBG). The MBG material with good manufacturing properties but low bioactivity was electrically polarized at a high dc field. The electrical polarizability of MBG was evaluated by thermally stimulated depolarization current (TSDC) measurements and immersion in simulated body fluid (SBF). The early precipitation of calcium phosphate on the negatively charged surface of the treated MBG demonstrated the increased bioactivity of the material and confirmed its polarizability. It is suggested that the electrical interactions between the polarized MBG and ions in SBF promoted the formation of the calcium phosphate precipitation. Accordingly, the increased bioactivity of the MBG in SBF is suggested to demonstrate the conversion of MBG into electrovector ceramics by the polarization treatment.
APA, Harvard, Vancouver, ISO, and other styles
4

Abdullahi, Ismaila, and Ismail Zainol. "Synthesis, Characterization and Bioactivity of Chitosan Hydroxyapatite Composite Doped with Strontium." Solid State Phenomena 317 (May 2021): 217–26. http://dx.doi.org/10.4028/www.scientific.net/ssp.317.217.

Full text
Abstract:
Chitosan-hydroxyapatite composite doped with strontium was synthesised via in situ co-precipitation method. Physicochemical properties of the composite obtained were analysed using X-ray diffraction (XRD), infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM), energy dispersive X-ray spectroscopy (EDX) and Thermogravimetry with differential thermal analysis (DT-TGA). The synthesized composite was subjected to bioactivity studies in simulated body fluid (SBF). The calcium release from the sample in SBF was measured using atomic absorption spectroscopy (AAS). The physicochemical properties and bioactivity of the novel composite was compared with that of hydroxyapatite, strontium doped hydroxyapatite and chitosan hydroxyapatite. The in vitro bioactivity studies of the novel composite showed that it has a higher release of Ca2+ in the SBF compared to the other samples. The novel material was also found to induce more Ca2+ deposition after 28 days of immersion in the SBF. Hence, the novel composite material has the potential to be used as biomaterials for clinical application.
APA, Harvard, Vancouver, ISO, and other styles
5

Zamin, Hasnat, Takeshi Yabutsuka, and Shigeomi Takai. "Bioactivity Assessment of Apatite Nuclei-PVDF Composite Thin Films." Key Engineering Materials 782 (October 2018): 78–83. http://dx.doi.org/10.4028/www.scientific.net/kem.782.78.

Full text
Abstract:
Particles of calcium phosphate were precipitated by raising the temperature and the pH of simulated body fluid (SBF) named Apatite Nuclei (AN). AN and polyvinylidene fluoride (PVDF) composites thin films with different weight percentages of AN in PVDF were fabricated by solution casting technique, using doctor blade method. In order to assess the bioactivity, the thin films were soaked in simulated body fluid (SBF). It was found that the film containing 30 wt.% of AN in PVDF actively induced hydroxyapatite formation in 3 days soaking period in SBF.
APA, Harvard, Vancouver, ISO, and other styles
6

He, Yuan, Ling Feng Dai, Shi Hui Wang, Ya Nan Sun, Wei Shi, and Dong Tao Ge. "Towards Enhanced Bioactivity: Calcium Ion-Doped Polypyrrole." Advanced Materials Research 941-944 (June 2014): 1168–73. http://dx.doi.org/10.4028/www.scientific.net/amr.941-944.1168.

Full text
Abstract:
Based on the unique redox property of electrically conductive polymers, Ca2+ was incorporated into polypyrrole (PPy) film that previously doped with polyelectrolyte heparin. Then the apatite-forming ability of the Ca2+-doped PPy was examined by a biomimetic method using stimulated body fluid (SBF), which has ion concentration nearly equal to those of human blood plasma. It was found that the Ca2+-doped PPy successfully formed bonelike apatite deposition on its surface after soaking in SBF for only 3 days, whereas the similar apatite deposition was formed on Ca2+-free PPy after soaking in SBF for 7 days. These indicated that the entrapment of Ca2+ into PPy could accelerate the formation of apatite deposition and the Ca2+-doped PPy was possessed of enhanced bioactivity. It is expected that the Ca2+-doped PPy would be a useful bioactive coating material of metallic medical devices or tissue engineering scaffolds to promote the bone tissue regeneration.
APA, Harvard, Vancouver, ISO, and other styles
7

Niu, Ya Ran, Xue Bin Zheng, and You Tao Xie. "Influence of Surface Composition of Silicon-Based Material on their Bioactivity." Key Engineering Materials 512-515 (June 2012): 1826–29. http://dx.doi.org/10.4028/www.scientific.net/kem.512-515.1826.

Full text
Abstract:
Silicon coatings were prepared by vacuum plasma spraying (VPS) and air plasma spraying (APS) technologies. The samples were hydrothermally treated and then incubated in simulated body fluid (SBF) to evaluate their bioactivity and silicon wafer was used as control sample at the same time. The SBF test showed that a Ca-P layer was formed on the surface of silicon wafer and VPS-Si coating after immersion in SBF for certain time, indicating their improved bioactivity. Whereas no Ca-P layer was found on the surface of APS-Si coating. The results of X-ray photoelectron spectroscopy showed that the Si/O atomic ratio and chemical depth profiles of the silicon oxide films on the surface of silicon wafer, VPS-Si and APS-Si coatings were different. The results indicated that the bioactivity difference of silicon-based material resulted from the different composition of their surface. Hydrothermal treatment maybe a favorable method to improve the bioactivity of silicon-based material having silicon oxide of non-stoichiometric Si/O atomic ratio.
APA, Harvard, Vancouver, ISO, and other styles
8

Wu, Chengtie, and Yin Xiao. "Article Commentary: Evaluation of the In Vitro Bioactivity of Bioceramics." Bone and Tissue Regeneration Insights 2 (January 2009): BTRI.S3188. http://dx.doi.org/10.4137/btri.s3188.

Full text
Abstract:
Two common methods have been used to evaluate the in vitro bioactivity of bioceramics for the application of bone repair. One is to evaluate the ability of apatite formation by soaking ceramics in simulated body fluids (SBF); the other method is to evaluate the effect of ceramics on osteogenic differentiation using cell experiments. Both methods have their own drawbacks in evaluating the in vitro bioactivity of bioceramics. In this commentary paper we review the application of both methods in bioactivity of bioceramics and conclude that (i) SBF method is an efficient method to investigate the in vitro bioactivity of silicate-based bioceramics, (ii) cellular bioactivity of bioceramics should be investigated by evaluating their stimulatory ability using standard bioceramics as controls; and (iii) the combination of these two methods to evaluate the in vitro bioactivity of bioceramics can improve the screening efficiency for the selection of bioactive ceramics for bone regeneration.
APA, Harvard, Vancouver, ISO, and other styles
9

Hatzistavrou, E., Xanthippi Chatzistavrou, Lambrini Papadopoulou, Nikolaos Kantiranis, K. Chrissafis, Aldo Roberto Boccaccini, and Konstantinos M. Paraskevopoulos. "Sol-Gel Hydroxyapatite-CaO Composites: Fabrication and Bioactivity Studies." Key Engineering Materials 396-398 (October 2008): 99–102. http://dx.doi.org/10.4028/www.scientific.net/kem.396-398.99.

Full text
Abstract:
In this study the fabrication and characterization of a novel sol-gel derived HAp-CaO composite material is investigated. The bioactive behavior of the fabricated composite was assessed by immersion studies in SBF. A brittle and weakly crystalline carbonate hydroxyapatite (HCAp) layer was found to develop few hours after the immersion in SBF confirming high bioactivity. The presence of CaO accelerates the formation of HCAp phase.
APA, Harvard, Vancouver, ISO, and other styles
10

Miyazaki, Toshiki, Moriyoshi Imamura, Eiichi Ishida, Masahiro Ashizuka, Chikara Ohtsuki, and Masao Tanihara. "Apatite Formation on Organic-Inorganic Hybrid Containing Sulfonic Group." Key Engineering Materials 284-286 (April 2005): 725–28. http://dx.doi.org/10.4028/www.scientific.net/kem.284-286.725.

Full text
Abstract:
Apatite formation in living body is essential condition for artificial materials to exhibit bone-bonding ability, i.e. bioactivity. It has been recently revealed that sulfonic group triggers apatite nucleation in body environment. Organic-inorganic hybrids consisting of organic polymer and the sulfonic group are therefore expected to be useful for novel bone-repairing materials exhibiting flexibility as well as bioactivity. In the present study, organic-inorganic hybrids were prepared from vinylsulfonic acid sodium salt and hydroxyethylmethacrylate (HEMA), a kind of acrylic polymer. Bioactivity of the hybrids was assessed in vitro by examining their acceptance of apatite formation in simulated body fluid (SBF, Kokubo solution). The obtained hybrids showed the apatite deposition after soaking in SBF within 7 d.
APA, Harvard, Vancouver, ISO, and other styles
11

Miola, Marta, Enrica Verné, Antonella Piredda, Sigrid Seuss, Sandra Cabanas-Polo, and Aldo R. Boccaccini. "Development and Characterization of PEEK/B2O3-Doped 45S5 Bioactive Glass Composite Coatings Obtained by Electrophoretic Deposition." Key Engineering Materials 654 (July 2015): 165–69. http://dx.doi.org/10.4028/www.scientific.net/kem.654.165.

Full text
Abstract:
Three different glasses were synthesized by doping 45S5 bioactive glass with B2O3. The bioactivity of the glasses was evaluated by immersion in simulated body fluid (SBF) up to 3 days; all glasses showed the precipitation of hydroxyapatite (HAp) after one day of soaking in SBF. Electrophoretic deposition (EPD) was used to prepare PEEK/B2O3-doped 45S5 glass composite coatings on stainless steel substrates. The coatings were characterized by means of tape test (ASTM D3359-B), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), contact angle measurements, thermogravimetric analysis and in vitro bioactivity test. All composite coatings exhibited a porous and homogenous structure with a hydrophobic surface, according to the wettability test. The in vitro test in SBF demonstrated that the coatings were highly bioactive.
APA, Harvard, Vancouver, ISO, and other styles
12

Radev, Lachezar, Darina Zheleva, and Irena Michailova. "In vitro bioactivity of Polyurethane/85S Bioglass composite scaffolds." Open Chemistry 11, no. 9 (September 1, 2013): 1439–46. http://dx.doi.org/10.2478/s11532-013-0273-9.

Full text
Abstract:
AbstractIn the present work Polyurethane (PU)/Bioglass (BG) composite materials were synthesized with different content of BG (10 and 20 mol.%) as filler. The 85S Bioglass was synthesized via polystep sol-gel method. The chemical composition of BG is 85SiO2-10CaO-5P2O5 (wt.%). The synthesis of PU was carried out by a two-step polyaddition reaction. The 85S BG was added in situ during the polymerization reaction. In vitro bioactivity of the prepared composites was examined in the presence of 1.5 SBF for 7 days in static conditions. The structure of synthesized PU/BG composites before and after in vitro test was determined by XRD, FTIR and SEM. XRD of the samples before in vitro test proved that the phase of γCa2P2O7 in the PU/20BG is visible. FTIR revealed the presence of urethane bond between OH-(from BG) and NCO groups (from PU). Based on FTIR results after in vitro test in 1.5 SBF solutions, A/B-carbonate containing hydroxyapatite (CO3HA) was formed. XRD proved that HA was formed on the surface of the samples, but Ca2P2O7 does not undergo any changes in the 1.5 SBF solution. SEM depicted the nano-HA agglomerated in spherical particles after immersion in 1.5 SBF for 7 days.
APA, Harvard, Vancouver, ISO, and other styles
13

Arumugam, Madhan Kumar, Mohamed A. Hussein, Akeem Yusuf Adesina, and Nasser Al-Aqeeli. "In Vitro Corrosion and Bioactivity Performance of Surface-Treated Ti-20Nb-13Zr Alloys for Orthopedic Applications." Coatings 9, no. 5 (May 27, 2019): 344. http://dx.doi.org/10.3390/coatings9050344.

Full text
Abstract:
The influence of surface treatments on the microstructure, in vitro bioactivity and corrosion protection performance of newly fabricated Ti-20Nb-13Zr (TNZ) alloys was evaluated in simulated body fluid (SBF). The TNZ alloy specimens were treated with separate aqueous solutions of NaOH and H2O2 and with a mixture of both, followed by thermal treatment. The nanoporous network surface structure observed in H2O2-treated and alkali-treated specimens was entirely different from the rod-like morphology observed in alkali hydrogen peroxide-treated specimens. XRD results revealed the formation of TiO2 and sodium titanate layers on the TNZ specimens during surface treatments. The water contact angle results implied that the surface-treated specimens exhibited improved surface hydrophilicity, which probably improved the bioactivity of the TNZ specimens. The in vitro corrosion protection performance of the surface-treated TNZ specimens was analyzed using electrochemical corrosion testing in SBF, and the obtained results indicated that the surface-treated specimens exhibited improved corrosion resistance performance compared to that of the bare TNZ specimen. The in vitro bioactivity of the treated TNZ specimens was assessed by soaking in SBF, and all the investigated treated specimens showed numerous apatite nucleation spheres within 3 days of immersion in SBF.
APA, Harvard, Vancouver, ISO, and other styles
14

Jurgelane, Inga, Armands Buss, and Dagnija Loca. "Bovine Serum Albumin Adsorption onto Hydroxyapatite and Biphasic Calcium Phosphate Ceramic Granules." Key Engineering Materials 721 (December 2016): 197–201. http://dx.doi.org/10.4028/www.scientific.net/kem.721.197.

Full text
Abstract:
Calcium phosphate ceramics are one of the most studied biomaterials for bone substitution and regeneration. Bioactivity is one of the most important properties for these materials and it can be evaluated by adsorption of proteins and by hydroxyapatite formation on the surface in simulated body fluid (SBF). The aim of this work was to evaluate the bioactivity of ceramic granules with various hydroxyapatite (HAp) and beta tricalcium phosphate (β-TCP) ratios by adsorption of bovine serum albumin (BSA) in SBF and phosphate saline buffer (PBS) solution. The highest adsorption capacity in both solutions was observed for biphasic calcium phosphate sample with HAp/β-TCP ratio 50/50 but the lowest – for sample 10/90. The adsorption capacity of all samples was more than 2 times higher in SBF media than in PBS. The possibility of hydroxyapatite formation was evaluated by changes of Ca2+ concentration in SBF. After 5 days of incubation at 37oC all samples showed a decrease in Ca2+ concentration.
APA, Harvard, Vancouver, ISO, and other styles
15

Kon, Masayuki, Razia Sultana, Emi Fujihara, Kenzo Asaoka, and Tetsuo Ichikawa. "Calcium Titanate Film-Coating on Titanium with Hydrothermal Treatments." Key Engineering Materials 330-332 (February 2007): 737–40. http://dx.doi.org/10.4028/www.scientific.net/kem.330-332.737.

Full text
Abstract:
Film-coating on the surface of titanium was investigated by hydrothermal treatments with a maximal pressure of 6.3 MPa (280°C) in CaO solution and water to improve bioactivity and biocompatibility. As a result, calcium titanate (CaTiO3) film was formed on the titanium surface. The surface-coated titanium was immersed in a simulated body fluid (SBF) to estimate its bioactivity. Apatite precipitation was observed on all hydrothermal-treated titanium surfaces after immersion in SBF for 4 weeks. In particular, the apatite precipitation of titanium treated with 6.3 MPa in CaO solution was clearer and larger in amount than those of all other hydrothermal-treated specimens. The results suggest that surface modification of titanium with high-pressure hydrothermal treatments can be expected to improve bioactivity and biocompatibility.
APA, Harvard, Vancouver, ISO, and other styles
16

Balgová, Zuzana, Martin Palou, Jaromír Wasserbauer, Gabriela Lutišanová, and Jana Kozánkováb. "Preparation, characterization and in vitro bioactivity of polyvinyl alcohol-hydroxyapatite biphasique membranes." Acta Chimica Slovaca 6, no. 1 (April 1, 2013): 8–14. http://dx.doi.org/10.2478/acs-2013-0002.

Full text
Abstract:
Abstract Six membranes of polyvinyl alcohol (PVA) with various weight percent - 0 %, 10 %, 20 %, 30 %, 40 % and 50 % of hydroxyapatite (HA) were prepared. Fourier Transform Infrared (FTIR) spectroscopy was used to identify the different functional groups in membrane composites. The surface morphology was examined through scanning electron microscope. The in vitro bioactivity tests in Simulated Blood Fluid (SBF) have been performed up to 28 days, especially for membrane containing 50 wt. % HA. SEM was used to characterize surface microstructure of biocomposite membranes before and after immersion in SBF. It was observed the formation of clusters within membranes with increasing amount of HA particles due to hydrogen bond and also the agglomeration and crystal growth of HA particles during drying of membranes. The bioactivity was found increasing with time immersion of biocomposite materials in SBF solution.
APA, Harvard, Vancouver, ISO, and other styles
17

Ma, Chen, Ying Hui Wang, Mu Qin Li, and Li Jie Qu. "Bioactivity, Wear and Corrosion Resistant Properties of Rare Earth/Calcium Phosphate Composite Coatings." Key Engineering Materials 368-372 (February 2008): 1194–97. http://dx.doi.org/10.4028/www.scientific.net/kem.368-372.1194.

Full text
Abstract:
Rare earth/calcium phosphate composite coatings were fabricated on the surface of Ti-6Al-4V by micro-arc oxidation (MAO) technique. The wear properties and corrosion resistant of rare earth/ calcium phosphate composite coatings in the simulated body fluid (SBF) have been investigated and the bioactivity of the composite coatings were evaluated. The results show that the friction coefficient of the composite coatings in the SBF is only 0.15~0.18 and the anode polarization potential of the coating has been obviously enhanced about 0.18V compared with that of coatings of calcium phosphate coatings. So the composite coatings have excellent wear and corrosion resistant properties. XRD analysis indicates that the composite coatings can induce hydroxyapatite to form on its surface after soaked in SBF for 9d, which shows that the composite coatings own good bioactivity.
APA, Harvard, Vancouver, ISO, and other styles
18

Bouhazma, Sara, Imane Adouar, Sanae Chajri, Smaiel Herradi, Mohamed Khaldi, Abdelkrim Ouammou, Brahim El Bali, Mohammed Mansori, and Mohammed Lachkar. "A sol-gel synthesis, characterization and in vitro bioactivity of binary, ternary and quaternary bioglasses with high mechanical strength." Mediterranean Journal of Chemistry 10, no. 4 (April 15, 2020): 310–18. http://dx.doi.org/10.13171/mjc02004151058ml.

Full text
Abstract:
Bioactive powders of the binary SiO2-CaO, ternary SiO2-CaO-P2O5 and quaternary systems SiO2-CaO-P2O5-Na2O/Mg2O were synthesized using a sol-gel route. The gels were converted into bioglasses powders by heat treatments at the temperature of 700°C. The resulting materials were characterized by X-ray diffraction (XRD), Fourier Transform Infrared spectroscopy (FTIR), Environmental Scanning Electron Microscopy (ESEM) and in vitro bioactivity in acellular Simulated Body Fluid (SBF). The in vitro tests showed that the samples had good apatite-forming ability. Glasses doped with sodium and magnesium show good results in terms of bioactivity and mechanical properties. The results showed that the quaternary glass SiO2-CaO-P2O5-Na2O containing Na is the most bioactive, only 6 hours after its immersion in SBF; a layer of hydroxycarbonated apatite (HAC) was deposited on the glass and compressive strength of up to 233.08 MPa with a porosity of 11.02%, due to the presence of the Na2Ca2Si3O9 phase. Magnesium also affects bioactivity because it has improved from binary to ternary to quaternary doped with magnesium, bioactive from 12h of contact with the SBF.
APA, Harvard, Vancouver, ISO, and other styles
19

Vitkovič, Martin, Maha Noaman, Martin Palou, and Soňa Jantová. "Potential applications of fluorhydroxyapatite as biomaterials in medicine." Open Chemistry 7, no. 2 (June 1, 2009): 246–51. http://dx.doi.org/10.2478/s11532-009-0010-6.

Full text
Abstract:
AbstractThe present work was undertaken to investigate the bioactivity and cytotoxicity of fluorhydroxyapatite ceramics. The bioactivity was evaluated by in vitro testing in simulated body fluid (SBF), in which ion concentrations are almost identical with inorganic ion concentrations of human blood plasma. Pellets of FA, HA and FHA were immersed in SBF for 48 hours, 1 week and 4 weeks at 36.5°C. Changes of the surface microstructure of the samples were observed by scanning electron microscopy (SEM). 48 hours and one week immersion in SBF did not result in any substantial progress in bioactivity. After 4 weeks in SBF a new biologically active layer was created on the surface of the biomaterials. In addition, the embryonal mouse fibroblast cell line NIH-3T3 was used for a comparative study of basal cytotoxicity of FHA, HA and FA discs. The sensitivity of these cells for tested biomaterials was evaluated on the basis of two cytotoxic end points: cell proliferation and cell morphology. The basal cytotoxicity of FHA, FA and HA discs was measured by a direct contact method. After 24, 48 and 72 hours, the cell growth was evaluated by direct counting of non-affected cells and cells treated by biomaterials. After 72 hours of biomaterials treatment, about 25% inhibition of cell number and unchanged morphology was found.
APA, Harvard, Vancouver, ISO, and other styles
20

Ni, Shirong, Ruilin Du, and Siyu Ni. "The Influence of Na and Ti on theIn VitroDegradation and Bioactivity in 58S Sol-Gel Bioactive Glass." Advances in Materials Science and Engineering 2012 (2012): 1–7. http://dx.doi.org/10.1155/2012/730810.

Full text
Abstract:
The aim of this study was to investigate the effect of Na and Ti on thein vitrodegradation and bioactivity in the 58S bioactive glass. The degradation was evaluated through the activation energy of Si ion release from bioactive glasses and the weight loss of bioactive glasses in Tris-HCl buffer solution. Thein vitrobioactivity of the bioactive glasses was investigated by analysis of apatite-formation ability in the simulated body fluid (SBF). The results showed that Na in the 58S glass accelerated the dissolution rate of the glass, whereas Ti in the 58S glass slowed down the rate of glass solubility. Bioactivity tests showed that Na in glass increased the apatite-forming ability in SBF. In contrast, Ti in glass retards the apatite formation at the initial stage of SBF soaking but does not affect the growth of apatite after long periods of soaking.
APA, Harvard, Vancouver, ISO, and other styles
21

Kim, Jeong Jun, and Jong Kook Lee. "Bioactivity Improvement of Zirconia Substrate by Hydroxyapatite Coating Using Room Temperature Spray Processing." Journal of Nanoscience and Nanotechnology 21, no. 8 (August 1, 2021): 4151–56. http://dx.doi.org/10.1166/jnn.2021.19373.

Full text
Abstract:
Zirconia ceramics has a bioinert property with low bioactivity. So, it is necessary to improve its low bioactivity by the surface modification using effective coating methods. In this study, we fabricated the hydroxyapatite-coated zirconia substrate by room temperature spray processing to improve the bioactivity of the zirconia implant and investigated its coating effect on the biological performance of zirconia substrate via an in vitro test in simulated body fluid (SBF) solution. Before the room temperature spray coating was completed, size-controlled hydroxyapatite powder that had an average size of 4.5 μm, was obtained by the calcination and milling of a commercial powder. By controlling the processing parameters, such as spraying distance, and deposition cycles, we fabricated homogeneous and dense hydroxyapatite coatings on zirconia substrate. Surface morphology, coating thickness, and microstructure were dependent on deposition cycles, and were related to surface roughness and bioactivity. Zirconia substrates with wave-patterned and roughened hydroxyapatite coatings demonstrated high bioactivity in their in vitro tests. Via the immersion test in an SBF solution, surface dissolution and new precipitates of hydroxyapatite were observed on coated zirconia substrate, indicating the degree of bioactivity.
APA, Harvard, Vancouver, ISO, and other styles
22

Mahabole, Megha, Manjushree Bahir, and Rajendra Khairnar. "Mn Blended Hydroxyapatite Nanoceramic: Bioactivity, Dielectric and Luminescence Studies." Journal of Biomimetics, Biomaterials and Tissue Engineering 18 (December 2013): 43–59. http://dx.doi.org/10.4028/www.scientific.net/jbbte.18.43.

Full text
Abstract:
Abstract: In this study, in-vitro bioactivity of manganese blended hydroxyapatite (Mn-HAp) pellets is carried out using simulated body fluid (SBF) solution. The incubated Mn-HAp samples are characterized by XRD, FTIR and SEM/EDAX. Dielectric and photoluminescence properties of Mn-HAp samples are studied as a function of incubation period in SBF. XRD profiles show that hexagonal apatite structure remains intact after partial replacement of calcium ions by manganese ions and even after incubation. The change in absorption due to phosphate group, depicted in FTIR spectra, for incubated samples confirms growth of apatite on Mn-HAp surface. SEM/ EDAX studies suggest that Mn-HAp surface promotes the growth of apatite without changing its structure due to apatite nucleation and growth on the surface of Mn-HAp. The value of dielectric constant of Mn-HAp increases after incubation. Increase in period of immersion in m-SBF leads to decrease in dielectric constant of manganese exchanged hydroxyapatite. The photoluminescence (PL) study reveals that the Mn-HAp can be used stable and efficient blue luminescent material.
APA, Harvard, Vancouver, ISO, and other styles
23

Radev, Lachezar, Irena Michailova, Silviya Stateva, Diana Zaimova, Hristo Georgiev, and Margarita Apostolova. "In vitro bioactivity of glass-ceramic/fibroin composites." Processing and Application of Ceramics 11, no. 2 (2017): 136–46. http://dx.doi.org/10.2298/pac1702136r.

Full text
Abstract:
Bioactive composite materials were prepared by mixing 20 wt.% of silk fibroin (SF) and 80 wt.% of glassceramics from CaO-SiO2-P2O5-MgO system. In vitro bioactivity of the prepared composites was evaluated in 1.5 simulated body fluid (1.5 SBF) in static conditions. The obtained samples before and after in vitro tests were characterized by X-ray diffraction (XRD) analysis, Fourier transform infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS). The changes in 1.5 SBF solutions after soaking the samples were evaluated by inductively coupled plasma atomic emission spectroscopy (ICP-AES). MG63 osteosarcoma cells were used for the biological experiments. The obtained experimental data proved that the synthesized composites exhibit excellent in vitro bioactivity.
APA, Harvard, Vancouver, ISO, and other styles
24

Hiruta, Tomoko, Takeshi Yabutsuka, Shin Watanabe, Keito Fukushima, Shigeomi Takai, and Takeshi Yao. "Apatite Formation Ability of Bioactive Bearing Grade Polyetheretherketone Fabricated by Incorporation of Apatite Nuclei." Key Engineering Materials 758 (November 2017): 69–74. http://dx.doi.org/10.4028/www.scientific.net/kem.758.69.

Full text
Abstract:
The fabrication process of bioactive bearing grade PEEK was consisted of three steps. First, micropores were formed on the bearing grade PEEK plates by sulfuric acid treatment. Second, plates were exposed to O2 plasma by glow discharge. Finally, the plates were immediately immersed in SBF controlled at pH 8.4 at 25.0 °C and held at 70 °C for 24 hours. By this final treatment, Apatite Nuclei were precipitated inside of the pores. In order to investigate which step has the most influence on enriching bioactivity, four types of samples were obtained by changing the combinations of each process and evaluated the bioactivity by using SBF.
APA, Harvard, Vancouver, ISO, and other styles
25

Yabutsuka, Takeshi, Hiroto Mizutani, Shigeomi Takai, and Takeshi Yao. "Fabrication of Bioactive Cobalt-Chromium Alloys by Incorporation of Apatite Nuclei." Key Engineering Materials 720 (November 2016): 180–84. http://dx.doi.org/10.4028/www.scientific.net/kem.720.180.

Full text
Abstract:
Micrometer-sized pores were formed on the surface of cobalt-chromium (Co-Cr) alloys by sandblasting method. In order to provide bioactivity to the Co-Cr alloys, the alloys were soaked in SBF and heated. By this treatment, amorphous calcium phosphate film was formed on the Co-Cr alloys. Apatite-forming ability of the specimens was evaluated by using SBF.
APA, Harvard, Vancouver, ISO, and other styles
26

Lazaro, Gilderman Silva, Silmara Caldas Santos, Luiz Eduardo Almeida, Ledjane Silva Barreto, and Euler Araujo dos Santos. "The Equilibrium between Calcite and Apatite Precipitation onto Bioglass from Three Different Aqueous Media." Key Engineering Materials 493-494 (October 2011): 102–7. http://dx.doi.org/10.4028/www.scientific.net/kem.493-494.102.

Full text
Abstract:
It has been reported that there is a slight equilibrium between calcite and apatite precipitation from SBF solution during typical bioactivity assays, once it is supersaturating in both ionic precursors. In order to better understand this mechanism, we have proposed here to evaluate the role of three different aqueous medium (water, SBF and McCoy), under equilibrium (agitation) and out of equilibrium (no agitation).
APA, Harvard, Vancouver, ISO, and other styles
27

Sabudin, Salina, Sudirman Sahid, Nor Shahida Kader Bashah, Shirin Ibrahim, Zul Hazmi Hussin, and Muhamad Anas Marzuke. "In Vitro Bioactivity of Macroporous Calcium Phosphate Scaffold for Biomedical Application." Key Engineering Materials 705 (August 2016): 309–14. http://dx.doi.org/10.4028/www.scientific.net/kem.705.309.

Full text
Abstract:
In this study, the effects of macroporous calcium phosphate (MCP) scaffold on bioactivity as an in-vitro model has been investigated. MCP scaffold was prepared using foam replication technique by combination of ceramic and polyurethane (PU). MCP was examined by scanning electron microscope (SEM) and X-ray diffractometer (XRD) to confirm its microstructure and phase composition respectively. Bioactivity in simulated body fluid (SBF) was characterized by apatite mineralisation on MCP scaffold surface, pH, calcium (Ca2+) and phosphate (PO43-) ion dissolution and compressive strength using universal testing machine (UTM). Experimental results showed the formation of apatite around the MCP scaffold after 30 days in SBF. pH value was gradually decreased up to 7 days and constant until 30 days. Dissolution of Ca2+ and PO43- ion in SBF due to the occurrence of MCP degradation, hence the compressive strength are gradually decreased gradually in line with immersion period. This material may be promising for biomedical application.
APA, Harvard, Vancouver, ISO, and other styles
28

Kishi, Shigeki, Norikazu Okimoto, Satoshi Nakamura, Keishi Nishio, Kazuaki Hashimoto, Yoshitomo Toda, and Kimihiro Yamashita. "Chemicovector Effect of Nano-Size-Hydroxyapatite Doped YSZ Ceramics on Apatite Formability in SBF." Key Engineering Materials 309-311 (May 2006): 589–92. http://dx.doi.org/10.4028/www.scientific.net/kem.309-311.589.

Full text
Abstract:
To produce ceramics with high mechanical strength and bioactivity, we developed the little amount of nano-sized hydroxyapatite (HA)-doped zirconia composite ceramics (nanoHA-Z). The bioactivity of the nanoHA-Z was studied by in vitro estimation with simulated body fluid (SBF). Scanning electron microscopy observation showed deposited bone-like apatite layer entire covering the surface of nanoHA-Z ceramics in SBF. The enhanced apatite formability was attributed to higher Ca and PO4 concentrations in the vicinities of the nanoHA-Z surfaces due to the dissolution of the β-tricalcium phosphate decomposed from the added HA. Utilization of Chemicovector effect was proved to be one of the powerful approaches for improvement method of biomaterials.
APA, Harvard, Vancouver, ISO, and other styles
29

Erol, M., A. Özyuğuran, Ö. Özarpat, and S. Küçükbayrak. "Investigation of Strontium Effect on the Bioactive Behavior of Glasses in the System SiO2-CaO-P2O5-Na2O-SrO." Key Engineering Materials 493-494 (October 2011): 68–73. http://dx.doi.org/10.4028/www.scientific.net/kem.493-494.68.

Full text
Abstract:
In this study, it was aimed to produce bioactive glasses (SiO2-CaO-P2O5-Na2O-SrO) with the substitution of strontium in different weight percentages. Physical, thermal, and in vitro biological properties of the glasses were studied and compared to each other. In vitro simulated body fluid studies were performed to investigate the bioactivity of the produced glass samples. Scanning electron microscopy, X-ray diffraction, ultraviolet spectroscopy and inductively coupled plasma techniques were used to monitor changes in the glass surface and SBF composition. The results showed that all glasses favored precipitation of calcium phosphate layer when they were soaked in SBF; however bioactivity of the glasses increased with the increase of strontium content in the glasses.
APA, Harvard, Vancouver, ISO, and other styles
30

Mohd Tajudin, Muhammad Hanis, Zafirah Tapsir, Lukman Hakim Ismail, and Syafiqah Saidin. "Formation of Carbonated Apatite Layer in 1.5× Simulated Body Fluid at Different Refreshing Time." Key Engineering Materials 705 (August 2016): 304–8. http://dx.doi.org/10.4028/www.scientific.net/kem.705.304.

Full text
Abstract:
Bioactivity analysis in simulated body fluid (SBF) is an experiment or protocol conducted to evaluate the bioactive properties of a sample without involving cells. The bioactive property is claimed based on the formation of apatite layer after immersion in SBF. This analysis consumes expensive chemical reagents and requires complex procedure in preparing and refreshing the solution. Therefore, the aim of this study was to identify significant alteration of refreshing time in the 1.5× SBF to form an apatite layer on a polydopamine (PDA) grafted stainless steel (SS316L) disk. The SS316L disks were pre-treated and grafted with a PDA layer to equip the bioinert metal surface with a bioactive film. The PDA grafted disks were subjected to bioactivity analysis in SBF for 7 days at different refreshing time (24 h, 48 h, 72 h and not refreshed up to 7 d). The surfaces were then characterised by FTIR, SEM-EDX, and contact angle analyses to determine its chemical composition, morphology and wettability properties. The PDA grafted disks that been subjected to 48 h refreshing time in SBF produced homogenous apatite formation with less agglomeration, closest theoretical Ca/P ratio and high hydrophilicity, suggesting the formation of preferable apatite layer with a reduction in the number of refreshing time.Bioactivity analysis in simulated body fluid (SBF) is an experiment or protocol conducted to evaluate the bioactive properties of a sample without involving cells. The bioactive property is claimed based on the formation of apatite layer after immersion in SBF. This analysis consumes expensive chemical reagents and requires complex procedure in preparing and refreshing the solution. Therefore, the aim of this study was to identify significant alteration of refreshing time in the 1.5× SBF to form an apatite layer on a polydopamine (PDA) grafted stainless steel (SS316L) disk. The SS316L disks were pre-treated and grafted with a PDA layer to equip the bioinert metal surface with a bioactive film. The PDA grafted disks were subjected to bioactivity analysis in SBF for 7 days at different refreshing time (24 h, 48 h, 72 h and not refreshed up to 7 d). The surfaces were then characterised by FTIR, SEM-EDX, and contact angle analyses to determine its chemical composition, morphology and wettability properties. The PDA grafted disks that been subjected to 48 h refreshing time in SBF produced homogenous apatite formation with less agglomeration, closest theoretical Ca/P ratio and high hydrophilicity, suggesting the formation of preferable apatite layer with a reduction in the number of refreshing time.
APA, Harvard, Vancouver, ISO, and other styles
31

Wang, Haiyang, Toshinari Maeda, and Toshiki Miyazaki. "Effect of Calcium Acetate Content on Apatite-Forming Ability and Mechanical Property of PMMA Bone Cement Modified with Quaternary Ammonium." Materials 13, no. 21 (November 6, 2020): 4998. http://dx.doi.org/10.3390/ma13214998.

Full text
Abstract:
Polymethyl methacrylate (PMMA)-based bone cement is a popular biomaterial used for fixation of artificial joints. A next-generation bone cement having bone-bonding ability, i.e., bioactivity and antibacterial property is desired. We previously revealed that PMMA cement added with 2-(tert-butylamino)ethyl methacrylate, γ-methacryloxypropyltrimethoxysilane and calcium acetate showed in vitro bioactivity and antibacterial activity. This cement contains calcium acetate at 20% of the powder component. Lower content of the calcium acetate is preferable, because the release of a lot of calcium salt may degrade mechanical properties in the body environment. In the present study, we investigate the effects of calcium acetate content on the setting property and mechanical strength of the cement and apatite formation in simulated body fluid (SBF). The setting time increased and the compressive strength decreased with an increase in calcium acetate content. Although the compressive strength decreased after immersion in SBF for 7 d, all the cements still satisfied the requirements of ISO5833. Apatite was formed in SBF within 7 d on the samples where the calcium acetate content was 5% or more. Therefore, it was found that PMMA cement having antibacterial properties and bioactivity can be obtained even if the amount of the calcium acetate is reduced to 5%.
APA, Harvard, Vancouver, ISO, and other styles
32

Zamin, Hasnat, Takeshi Yabutsuka, Shigeomi Takai, Hiroshi Sakaguchi, and Takeshi Yao. "Fabrication of Bioactive Zirconia by Doubled Sandblasting Process and Incorporation of Apatite Nuclei." Key Engineering Materials 829 (December 2019): 151–56. http://dx.doi.org/10.4028/www.scientific.net/kem.829.151.

Full text
Abstract:
In this study, we aimed to introduce bioactivity to bioinert zirconia by performing sandblasting process and subsequently depositing apatite nuclei (AN), which are fine particles of calcium phosphate precipitated by raising pH of SBF, on the surface of the zirconia samples. By soaking the AN treated zirconia samples in SBF, hydroxyapatite formation was observed in 1 day and high hydroxyapatite-forming ability was attained.
APA, Harvard, Vancouver, ISO, and other styles
33

Karashima, Ryoki, Takeshi Yabutsuka, and Takeshi Yao. "Fabrication of Bioactive Polylactic Acid Composite Formed by 3D Printer." Key Engineering Materials 631 (November 2014): 160–65. http://dx.doi.org/10.4028/www.scientific.net/kem.631.160.

Full text
Abstract:
We precipitated Apatite Nucleus (AN) by raising pH of SBF. We mixed various concentration of AN in polylactic acid (PLA) and pressed by uniaxial press and cold isostatic press. We investigated the effect of AN concentration on bioactivity. We fabricated composite of PLA and AN configurating the shape by using 3D printer. The composite showed high bioactivity.
APA, Harvard, Vancouver, ISO, and other styles
34

Chen, Ji Yong, You Rong Duan, Chun Lin Deng, Qi Yi Zhang, and Xing Dong Zhang. "A Comparative Study Between Dynamic and Static Simulated Body Fluid Methods." Key Engineering Materials 309-311 (May 2006): 271–74. http://dx.doi.org/10.4028/www.scientific.net/kem.309-311.271.

Full text
Abstract:
In vitro method has often been used in the biodegradation/bioactivity evaluation of bioactive ceramics for its convenience and saving in time and outlay. The simulated body fluid (SBF) suggested by Kokubo was a good simulation of the osteoproduction environment in osseous tissue and has been proved to be a good method to study the bioactivity of biomaterials and the mechanism of bone bonding. But SBF is not a suitable method to research the osteoinduction of biomaterials. The results from SBF were not consistent with that from in vivo in muscle. The local ion concentration is the key factors to affect the nucleation and growth of apatite. In muscle the effect of body fluid flowing on local ion concentration cannot be ignored. A dynamic SBF suggested by these authors of this paper not only simulated the ion concentration of body fluid, but also simulated the effect of body fluid flowing on the local ion concentration near the surface or in biomaterials in muscle. The results from the dynamic SBF were in good agreement with that of the implantation experiments in muscle. The results from dynamic SBF showed that apatite only formed on the walls of macropores of the porous CaP, no apatite formed on the surface of both dense and porous CaP. The new bone only formed on the walls of macropores of porous CaP implanted in muscles, no apatite or osseous tissue could be found on the surfaces of both porous and dense CaP. The dynamic SBF preferably simulated the osteoinduction environment in non-osseous tissue and can be used in osteoinductivity evaluation of bioceramics.
APA, Harvard, Vancouver, ISO, and other styles
35

Hsu, Y. H., I. G. Turner, and A. W. Miles. "Article Commentary: A Commentary on “Evaluation of the in vitro Bioactivity of Bioceramics”." Bone and Tissue Regeneration Insights 3 (January 2010): BTRI.S4128. http://dx.doi.org/10.4137/btri.s4128.

Full text
Abstract:
The interesting article reported in Bone and Tissue Regeneration Insights by Wu and Xiao entitled “Evaluation of the in vitro bioactivity of bioceramics” contrasts two methods (Simulated body fluid (SBF) and cell culture experiments) which have been commonly used to evaluate the in vitro bioactivity of bioceramics. Limitations in estimating the bioactivity of bioceramics using both methods have been reviewed. Therefore, Wu and Xiao suggest the combination of these two methods to evaluate the bioactivity of bioceramics can improve the screening efficiency for the selection of bioactive ceramics for bone regeneration.
APA, Harvard, Vancouver, ISO, and other styles
36

Oudadesse, Hassane, M. Mami, R. Dorbez-Sridi, P. Pellen-Mussi, F. Perez, S. Jeanne, D. Chauvel-Lebret, and G. Cathelineau. "Comparison of the Chemical Reactivity and Bioactivity of Two Bioactive Glasses 47S6 and 48S4." Key Engineering Materials 396-398 (October 2008): 107–10. http://dx.doi.org/10.4028/www.scientific.net/kem.396-398.107.

Full text
Abstract:
This work is focused on the bioactive glasses obtained by melting and rapid quenching. Two glasses with mineral composition of: 47% SiO2 - 26% CaO - 21% Na2O - 6% P2O5 and 48% SiO2 - 30% CaO - 18% Na2O - 4% P2O5 were investigated. The aim of this study was to establish the kinetics of HCAp layer formation “in vitro” and to control the adhesion and proliferation cells of the two glasses in contact with osseous cells. Obtained results permit to evaluate their chemical reactivity and their bioactivity after immersion in the SBF-K9. Ionic exchanges between biomaterials and SBF liquid during the “in vitro” experiments highlight the differences of the chemical reactivity and bioactivity of 47S6 and 48S4. The structural basis for the effect of cristallinity on the rates of HCA formation in vitro in favour of glasses was also established. The melt derived 47S6 and 48S4 glasses offer to surgeons new compositions with different bioactivity kinetic that bioglassÒ 45S6 and can be adaptable in some other bony pathology.
APA, Harvard, Vancouver, ISO, and other styles
37

Kung, Kuan Chen, Tzer Min Lee, and Truan Sheng Lui. "Influence of Strontium on In Vitro Bioactivity of Heat-Treated Porous Ca-P Ceramics on Titanium for Biomedical Applications." Key Engineering Materials 493-494 (October 2011): 453–57. http://dx.doi.org/10.4028/www.scientific.net/kem.493-494.453.

Full text
Abstract:
The bioactivity of materials was evaluated based on the ability to induce a bond-like apatite layer on the surface in simulated body fluid (SBF). The aim of this study was to investigate the coatings containing strontium on bioactivity after heat treatment. After the materials were soaked in SBF for 1 day, precipitates did not form on the surface of heat-treated MAO coating without strontium. The precipitates were observed on surface of heat-treated MAO coatings containing strontium. After 7 days, the surface of heat-treated MAO coatings containing strontium was completely covered with precipitates. The precipitates were found to be composed of fiber structures using scanning electron microscope (SEM). The phase was identified as the apatite phase using thin film X-ray diffraction (TF-XRD). The results show that heat-treated MAO coatings containing strontium can induce the formation of an apatite layer on their surface. All finding in this study indicated that heat-treated MAO coatings containing strontium have good bioactivity for clinical applications.
APA, Harvard, Vancouver, ISO, and other styles
38

Dey, Reshmi, Pranjali Nanda, and Arunachalam Thirugnanam. "Bioactivity of Chemically Modified Porous Titanium." Materials Science Forum 830-831 (September 2015): 518–21. http://dx.doi.org/10.4028/www.scientific.net/msf.830-831.518.

Full text
Abstract:
The aim of the present investigation is to enhance in-vitro bioactivity and protein adsorption of porous titanium with 3D interconnected pores by various chemical treatments (alkali, dual acid, citric acid and fluoride treatments). The untreated and treated samples were characterized using X-ray powder diffraction (XRD), optical microscopy and scanning electron microscopy (SEM). The protein adsorption study was carried out with Bradford’s reagent using Bovine Serum Albumin (BSA). The optical microscopy reveals that untreated Ti sample exhibited 41.36% surface porosity. The in-vitro bioactivity of the treated and untreated Ti sample was evaluated by immersing them in simulated body fluid (SBF) for different time intervals. The immersed samples were characterized using XRD and SEM to confirm the growth and morphology of apatite. It was observed that apatite deposition of fluoride treated sample was denser than other treated samples for the same period immersed in SBF. All the surface treated samples showed good protein adsorption. The alkali treated sample showed maximum protein adsorption amongst other chemically treated samples which may be due to enhanced micro-roughness and strong electrostatic affinity between the protein and the surface. The enhanced in vitro bioactivity in the surface treated porous titanium indicates that the healing time of the bone and implant in patients can be reduced with good osseointegration.
APA, Harvard, Vancouver, ISO, and other styles
39

Yoshida, Akihiko, Toshiki Miyazaki, Eiichi Ishida, and Masahiro Ashizuka. "Preparation of Cellulose-Carbonate Apatite Composites through Mechanochemical Reaction." Key Engineering Materials 284-286 (April 2005): 855–58. http://dx.doi.org/10.4028/www.scientific.net/kem.284-286.855.

Full text
Abstract:
Organic-inorganic composites composed of organic polymer and carbonate hydroxyapatite (CHAp) would be useful bone substitute materials exhibiting low young’s modulus and bone-bonding bioactivity. In this work, such a composite was synthesized from cellulose (CEL)and CHAp through mechanochemical reaction. Homogeneous bulk CEL-CHAp composites were obtained when poly( ε-caprolactone) (PCL) was added as plasticizer with PCL/(PCL+CEL) weight ratio of 20 wt% or less. The CEL-CHAp composites contained B-type CHAp in inorganic phase. The composites with (CEL+PCL)/(CHAp) weight ratio = 20/80 and 10/90 kept the shape in simulated body fluid (SBF), and showed apatite formation after soaking in SBF. Therefore, the CEL-CHAp composites are expected to be materials with low young’s modulus and bioactivity.
APA, Harvard, Vancouver, ISO, and other styles
40

Fukushima, Keito, Takeshi Yabutsuka, Shigeomi Takai, and Takeshi Yao. "Development of Bioactive PEEK by the Function of Apatite Nuclei." Key Engineering Materials 696 (May 2016): 145–50. http://dx.doi.org/10.4028/www.scientific.net/kem.696.145.

Full text
Abstract:
Micropores were formed on the surface of a polyetheretherketone (PEEK) by soaking in sulfuric acid. In order to provide bioactivity to PEEK, the surfaces of the specimens were treated with glow-discharge in O2 atmosphere and Apatite Nucleus (AN) was precipitated in the pores. The bioactivity of the specimens was evaluated by using SBF and adhesive strength of formed apatite layer was measured.
APA, Harvard, Vancouver, ISO, and other styles
41

Wu, Jin Ming, Min Wang, Satoshi Hayakawa, Kanji Tsuru, and Akiyoshi Osaka. "In Vitro Bioactivity of Hydrogen Peroxide Modified Titanium: Effects of Surface Morphology and Film Thickness." Key Engineering Materials 309-311 (May 2006): 407–10. http://dx.doi.org/10.4028/www.scientific.net/kem.309-311.407.

Full text
Abstract:
Anatase films with various morphologies were formed on Ti surface through different approaches using hydrogen peroxide solutions. A porous anatase surface was found to favor apatite deposition in SBF, or in vitro bioactivity. Thicker films with wider crack gaps also showed enhanced in vitro bioactivity. However, the most predominant effect was the abundance of Ti-OH functional groups incorporated in the anatase films.
APA, Harvard, Vancouver, ISO, and other styles
42

Rohanová, Dana, Aldo Roberto Boccaccini, Diana Horkavcová, Pavlína Bozděchová, Petr Bezdička, and Markéta Častorálová. "Is non-buffered DMEM solution a suitable medium for in vitro bioactivity tests?" J. Mater. Chem. B 2, no. 31 (2014): 5068–76. http://dx.doi.org/10.1039/c4tb00187g.

Full text
APA, Harvard, Vancouver, ISO, and other styles
43

Wang, Ya Ming, Yong Fa Song, Shun Lan Deng, Osaka Akiyoshi, Guang Xin Wang, and Yan Fu Yan. "Enhanced Bioactivity of Chemically Oxidization-Modified Titanium Alloys." Solid State Phenomena 281 (August 2018): 564–69. http://dx.doi.org/10.4028/www.scientific.net/ssp.281.564.

Full text
Abstract:
Anatase-type titanium dioxide oxide layer was formed on the surface of titanium alloy by chemical oxidation. 0.9 um thick anatase was obtained by soaking in a mixed solution of a certain proportion of hydrogen peroxide and hydrochloric acid and then heat treatment. The surface morphology, phase structures and composition of oxide layers were characterized by scanning electron microscope (SEM), energy dispersive X-ray spectroscopy (EDS) and X-ray diffraction (XRD). Thickness of titania coating was measured by the ball pit gauge. Inductively coupled plasma atomic emission spectroscopy (ICP-AES) was used to detect the change of Ca ion and P ion concentration in solution. The results showed that anatase layers deposited apatite within 4 days accompanying the decrease of pH when soaked in simulated human body fluid (SBF). Ion exchange between the negative ions and calcium ions in SBF is proposed as the mechanism operative to favor the deposition on apatite.
APA, Harvard, Vancouver, ISO, and other styles
44

Zhao, Ying, Tian Ying Xiong, Tie Fan Li, J. Wu, Hua-Zi Jin, and Li Bin Wang. "Study on the Bioactivity of Anodic Oxidized Titanium Alloy Induced by Alkali Treatment." Key Engineering Materials 309-311 (May 2006): 383–86. http://dx.doi.org/10.4028/www.scientific.net/kem.309-311.383.

Full text
Abstract:
Alkali treatment induced to form bonelike apatite layer on the surface of the anodic oxidized Ti6Al4V in 1.5 SBF. It was observed that some spherical apatite crystals were deposited on the surface of the sample for only 1 d. They gradually grew to cover the whole surface of the sample with further increasing soaking time. After 7 days of soaking in 1.5 SBF, apatite covered all the surfaces of the titanium alloys, and they packed very densely and uniformly. At the same time, large amount of new-formed apatite nuclei occurred on the first layer of apatite. The EDS and XRD results proved that all the new-formed phases were composed of apatite. Mechanism of the bioactivity of the anodic oxidized titanium alloys was related to the Ti-OH group formation, and the Ti-OH group would induce apatite formation in SBF.
APA, Harvard, Vancouver, ISO, and other styles
45

Adibnia, S., Ali Nemati, Mohammad Hosseien Fathi, and S. Baghshahi. "Synthesis and Characterization of Sol-Gel Derived Hydroxyapatite-Bioglass Composite Nanopowders for Biomedical Applications." Journal of Biomimetics, Biomaterials and Tissue Engineering 12 (February 2012): 51–57. http://dx.doi.org/10.4028/www.scientific.net/jbbte.12.51.

Full text
Abstract:
The main purpose of this study is to prepare and characterize hydroxyapatite (HA)–10%wt bioglass (BG) composite nanopowders and its bioactivity. Composites of hydroxyapatite with synthesized bioglass are prepared at various temperatures. Suitable calcination temperature is chosen by evaluating of the phase composition. X-ray diffraction (XRD), Transmission electron microscopy (TEM) and Scanning electron microscopy (SEM) techniques are utilized to characterize the prepared nanopowders. The bioactivity of the prepared composite samples is evaluated in an in vitro study by immersion of samples in simulated body fluid (SBF) for predicted time. Fourier transformed infrared (FTIR) spectroscopy and inductively coupled plasma (ICP) are used for evaluation of apatite formation and the bioactivity properties. Results show that HA-BG composite nanopowders are successfully prepared without any decomposition of hydroxyapatite. The suitable temperature for calcination is 600°C and the particle size of hydroxyapatite is about 40-70 nm. The apatite phase forms after 14 days immersing of the samples in SBF. It could be concluded that this process can be used to synthesize HA-BG composite nanopowders with improved bioactivity which is much needed for hard tissue repair and biomedical applications.
APA, Harvard, Vancouver, ISO, and other styles
46

Soleymani, Farzad, Rahmatollah Emadi, Sorour Sadeghzade, and Fariborz Tavangarian. "Bioactivity Behavior Evaluation of PCL-Chitosan-Nanobaghdadite Coating on AZ91 Magnesium Alloy in Simulated Body Fluid." Coatings 10, no. 3 (March 3, 2020): 231. http://dx.doi.org/10.3390/coatings10030231.

Full text
Abstract:
Polymer–ceramic composite coatings on magnesium-based alloys have attracted lots of attention in recent years, to control the speed of degradability and to enhance bioactivity and biocompatibility. In this study, to decrease the corrosion rate in a simulated body fluid (SBF) solution for long periods, to control degradability, and to enhance bioactivity, polycaprolactone–chitosan composite coatings with different percentages of baghdadite (0 wt.%, 3 wt.%, and 5 wt.%) were applied to an anodized AZ91 alloy. According to the results of the immersion test of the composite coating containing 3 wt.% baghdadite in a phosphate buffer solution (PBS), the corrosion rate decreased from 0.45 (for the AZ91 sample) to 0.11 mg/cm2·h after seven days of immersion. To evaluate the apatite formation capability of specimens, samples were immersed in an SBF solution. The results showed that the samples were bioactive as apatite layers formed on the surface of specimens. The composite coating containing 3 wt.% baghdadite showed the highest apatite-formation capability, with a controlled release of ions, and the lowest corrosion rate in the SBF.
APA, Harvard, Vancouver, ISO, and other styles
47

Kumar R., Rohith, Sangeetha Ashok Kumar, and K. Periyasami Bhuvana. "Preparation and Evaluation of Bioactivity of Porous Bioglass Tablets for Bone Tissue Regeneration." SciMedicine Journal 1, no. 3 (September 1, 2019): 112–23. http://dx.doi.org/10.28991/scimedj-2019-0103-1.

Full text
Abstract:
The present study endeavors in the preparation and characterization of semi crystalline 45S5 bioglass (BG) (SiO2-CaO-P2O5) through sol gel process. Dry press mold technique was used in the preparation porous BG tablets to examine the bioactivity through invitro studies. The synthesized BG powder was subjected to structural, morphological and mechanical characterization and the bioactivity was examined in vitro by immersing the BG tablet in the Simulated Body Fluid (SBF) solution. XRD pattern and the SEM micrographs revealed the semi crystalline nature of BG with spherical morphology. The elemental analysis confirms the presence of vital constituents required for Bone regeneration (Calcium, Phosphorous, Silica, and Sodium). The surface characterization of BG tablet reveals the pores structure of average pore size of 240nm which contributed to the high surface activity resulting in formation of carbonated hydroxy apatite (HCAP) when immersed in SBF. The disintegration studies denoted the stabilization period was after 48 of immersion of BG tablets in SBF solution. The compressive strength measurement of the tablet also reveals the higher mechanical stability.
APA, Harvard, Vancouver, ISO, and other styles
48

PARK, JONGEE, and ABDULLAH OZTURK. "BIOACTIVITY OF APATITE–WOLLASTONITE GLASS-CERAMICS PRODUCED BY MELTING CASTING." Surface Review and Letters 20, no. 01 (February 2013): 1350010. http://dx.doi.org/10.1142/s0218625x13500108.

Full text
Abstract:
Glass-ceramics containing only apatite and wollastonite crystals were produced in the system MgO-CaO-SiO2-P2O5-F by the melt casting process. The bioactivity of the glass-ceramics was determined by immersing the glass-ceramics in a simulated body fluid (SBF) and by assessing the resulting apatite formation on the free surface after various immersion durations. A 12-μm-thick apatite layer formed on the surface of the glass-ceramic containing only apatite crystals after 20 days immersion in SBF. However, the thickness of the apatite layer formed on the surface of the glass-ceramic containing apatite and wollastonite crystals was 1 μm. Results have shown that the bioactivity of glass-ceramic depends strongly on the type of crystal(s) developed during the glass-ceramic process and their proportion in the glassy matrix.
APA, Harvard, Vancouver, ISO, and other styles
49

Gorea, Maria, Marieta-Adriana Naghiu, Alexandra Avram, Ioan Petean, Aurora Mocanu, and Maria Tomoaia-Cotisel. "Novel Porous Forsterite Ceramics Biocompatibility and Bioactivity Evaluation." Revista de Chimie 71, no. 2 (March 3, 2020): 343–51. http://dx.doi.org/10.37358/rc.20.2.7935.

Full text
Abstract:
This study is aimed to evaluate the biocompatibility and bioactivity of some new porous forsterite ceramics (FCs) produced from high-purity nano forsterite powder, synthesized by an original sol-gel method, which was subjected to pressing into pellets, by using a poly vinyl alcohol solution as a binding component. Then, the raw pellets were sintered at 1200 �C, 1300 �C, 1400 �C and 1450 �C. The obtained four forsterite ceramics, FC-1200, FC-1300, FC-1400 and FC-1450, were fully characterized by density, porosity and shrinkage measurements. The forsterite ceramics exhibited excellent biocompatibility determined by an in vitro cell viability assay, such as MTT test. Furthermore, the in vitro bioactivity test was performed by immersing the forsterite ceramics into simulated body fluid (SBF) and examining the hydroxyapatite (HAP) formation on forsterite ceramics, as evidenced by XRD, FTIR, SEM with EDX. Moreover, the relationship between porous structure and bioactivity of forsterite ceramics in SBF as well as the performance of FC in a cell culture was evaluated. The findings strongly recommend these forsterite ceramics for biomedical applications, as potential bone substitutes.
APA, Harvard, Vancouver, ISO, and other styles
50

Xiao, Bin, Wei Zhong Yang, Da Li Zhou, Guang Fu Yin, and Huai Qing Chen. "Apatite Forming on the Surface of Apatite-Wollastonite/β-Tricalcium Phosphate Bioactive Ceramic." Key Engineering Materials 336-338 (April 2007): 1692–95. http://dx.doi.org/10.4028/www.scientific.net/kem.336-338.1692.

Full text
Abstract:
Bioactive composite of apatite-wollastonite(AW)/β-tricalcium phosphate (β-TCP) was prepared. The nucleation and growth of bio-apatite on the surface of AW/β-TCP ceramic in simulated body fluid (SBF) were investigated. The surface morphological structure, phase compositions and microstructure of the materials were characterized by scan electron microscopy (SEM), X-ray diffraction (XRD) and infrared spectroscopy (IR); Results show that the surfaces of the AW/β-TCP composite ceramic are covered with a layer of carbonate hydroxyapatite (HCA) when soaked in SBF, which indicates their bioactivity; Such HCA layer is composed of fine ball-like HA granules. With excellent bioactivity and bio-absorption, AW/β-TCP bioactive composite ceramic is expected to be a good candidate for bone substitutes and bone tissue engineering scaffolds.
APA, Harvard, Vancouver, ISO, and other styles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography