Relevant bibliographies by topics / Scaffold Bone Defect

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Scaffold Bone Defect'

Author: Grafiati
Published: 3 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Scaffold Bone Defect"

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Kim, Jong Min, Jun Sik Son, Seong Soo Kang, Gonhyung Kim, and Seok Hwa Choi. "Bone Regeneration of Hydroxyapatite/Alumina Bilayered Scaffold with 3 mm Passage-Like Medullary Canal in Canine Tibia Model." BioMed Research International 2015 (2015): 1–6. http://dx.doi.org/10.1155/2015/235108.

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The aim of this study was to evaluate the bone regeneration of hydroxyapatite (HA)/alumina bilayered scaffold with a 3 mm passage-like medullary canal in a beagle tibia model. A porous HA/alumina scaffold was fabricated using a polymeric template-coating technique. HA/alumina scaffold dimensions were 10 mm in outer diameter, 20 mm in length, and with either a 3 mm passage or no passage. A 20 mm segmental defect was induced using an oscillating saw through the diaphysis of the beagle tibia. The defects of six beagles were filled with HA/alumina bilayered scaffolds with a 3 mm passage or without
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Fang, Yifei, Yong Gong, Zhijian Yang, and Yan Chen. "Repair of Osteoporotic Bone Defects Using Adipose-Derived Stromal Cells and Umbilical Vein Endothelial Cells Seeded in Chitosan/Nanohydroxyapatite-P24 Nanocomposite Scaffolds." Journal of Nanomaterials 2021 (August 21, 2021): 1–11. http://dx.doi.org/10.1155/2021/6237130.

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Background. The cell regeneration and blood supply of bone defect lesions are restricted under osteoporotic pathological conditions, which make the healing of bone defect of osteoporosis still a great challenge. The current therapeutic strategies that mainly inhibit bone resorption are not always satisfactory for osteoporotic bone defects, which make the development of new therapies an urgent need. Methods. Previously, we prepared chitosan/nanohydroxyapatite (CS/nHA) biomimetic nanocomposite scaffolds for controlled delivery of bone morphogenetic protein 2-derived peptide (P24). In this study,
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Kessler, Franziska, Kevin Arnke, Benjamin Eggerschwiler, et al. "Murine iPSC-Loaded Scaffold Grafts Improve Bone Regeneration in Critical-Size Bone Defects." International Journal of Molecular Sciences 25, no. 10 (2024): 5555. http://dx.doi.org/10.3390/ijms25105555.

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In certain situations, bones do not heal completely after fracturing. One of these situations is a critical-size bone defect where the bone cannot heal spontaneously. In such a case, complex fracture treatment over a long period of time is required, which carries a relevant risk of complications. The common methods used, such as autologous and allogeneic grafts, do not always lead to successful treatment results. Current approaches to increasing bone formation to bridge the gap include the application of stem cells on the fracture side. While most studies investigated the use of mesenchymal st
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Li, Ming, Jianheng Liu, Xiang Cui, et al. "Osteogenesis effects of magnetic nanoparticles modified-porous scaffolds for the reconstruction of bone defect after bone tumor resection." Regenerative Biomaterials 6, no. 6 (2019): 373–81. http://dx.doi.org/10.1093/rb/rbz019.

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Abstract The treatment of bone defect after bone tumor resection is a great challenge for orthopedic surgeons. It should consider that not only to inhibit tumor growth and recurrence, but also to repair the defect and preserve the limb function. Hence, it is necessary to find an ideal functional biomaterial that can repair bone defects and inactivate tumor. Magnetic nanoparticles (MNPs) have its unique advantages to achieve targeted hyperthermia to avoid damage to surrounding normal tissues and promote osteoblastic activity and bone formation. Based on the previous stage, we successfully prepa
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Zhou, Shuai, Shihang Liu, Yan Wang, et al. "Advances in the Study of Bionic Mineralized Collagen, PLGA, Magnesium Ionomer Materials, and Their Composite Scaffolds for Bone Defect Treatment." Journal of Functional Biomaterials 14, no. 8 (2023): 406. http://dx.doi.org/10.3390/jfb14080406.

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The healing of bone defects after a fracture remains a key issue to be addressed. Globally, more than 20 million patients experience bone defects annually. Among all artificial bone repair materials that can aid healing, implantable scaffolds made from a mineralized collagen (MC) base have the strongest bionic properties. The MC/PLGA scaffold, created by adding Poly (lactic-co-glycolic acid) copolymer (PLGA) and magnesium metal to the MC substrate, plays a powerful role in promoting fracture healing because, on the one hand, it has good biocompatibility similar to that of MC; on the other hand
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Lim, Jin Xi, Min He, and Alphonsus Khin Sze Chong. "3D-printed Poly-Lactic Co-Glycolic Acid (PLGA) scaffolds in non-critical bone defects impede bone regeneration in rabbit tibia bone." Bio-Medical Materials and Engineering 32, no. 6 (2021): 375–81. http://dx.doi.org/10.3233/bme-216017.

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BACKGROUND: An increasing number of bone graft materials are commercially available and vary in their composition, mechanism of action, costs, and indications. OBJECTIVE: A commercially available PLGA scaffold produced using 3D printing technology has been used to promote the preservation of the alveolar socket after tooth extraction. We examined its influence on bone regeneration in long bones of New Zealand White rabbits. METHODS: 5.0-mm-diameter circular defects were created on the tibia bones of eight rabbits. Two groups were studied: (1) control group, in which the bone defects were left
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Kim, You Min, Min-Soo Ghim, Meiling Quan, Young Yul Kim, and Young-Sam Cho. "Experimental Verification of the Impact of the Contact Area between the Defect Site and the Scaffold on Bone Regeneration Efficacy." Polymers 16, no. 3 (2024): 338. http://dx.doi.org/10.3390/polym16030338.

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In the field of bone tissue engineering, which is being developed for the ideal restoration of bone defects, researchers are exploring the improvement of the bone regeneration efficacy of scaffolds through various approaches involving osteoconductive, osteoinductive, and angiogenic factors. In the current trend of research, there is also a suggestion that the topological factors of recent scaffolds may influence the attachment, migration, proliferation, and differentiation of bone cells. Building upon experimental confirmation of the effect of scaffold conformity with the defect site on enhanc
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Chen, Shuang S., Ophir Ortiz, Alexandra K. Pastino, et al. "Hybrid Bone Scaffold Induces Bone Bridging in Goat Calvarial Critical Size Defects Without Growth Factor Augmentation." Regenerative Engineering and Translational Medicine 6, no. 2 (2020): 189–200. http://dx.doi.org/10.1007/s40883-019-00144-z.

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Abstract In the present study, a series of four different scaffolds were comparatively evaluated in a goat calvarial critical size defect model. Such studies are only rarely reported in the literature. In our work, E1001(1k), a member of a large combinational library of tyrosine-derived polycarbonates (TyrPC), was used to prepare two calcium phosphate hybrid, biodegradable bone scaffolds. In one formulation, the widely used β-tricalcium phosphate (β-TCP) was incorporated into the polymer scaffold. In the second formulation, a coating of dicalcium phosphate dihydrate (DCPD, also known as brushi
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Mi, Xue, Zhenya Su, Yu Fu, Shiqi Li, and Anchun Mo. "3D printing of Ti3C2-MXene-incorporated composite scaffolds for accelerated bone regeneration." Biomedical Materials 17, no. 3 (2022): 035002. http://dx.doi.org/10.1088/1748-605x/ac5ffe.

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Abstract Grafting of bone-substitute biomaterials plays a vital role in the reconstruction of bone defects. However, the design of bioscaffolds with osteoinductive agents and biomimetic structures for regeneration of critical-sized bone defects is difficult. Ti3C2 MXene—belonging to a new class of 2D nanomaterials—exhibits excellent biocompatibility, and antibacterial properties, and promotes osteogenesis. However, its application in preparing 3D-printed tissue-engineered bone scaffolds for repairing bone defects has not been explored. In this work, Ti3C2 MXene was incorporated into composite
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Bergmann, Christian J. D., Jim C. E. Odekerken, Tim J. M. Welting, et al. "Calcium Phosphate Based Three-Dimensional Cold Plotted Bone Scaffolds for Critical Size Bone Defects." BioMed Research International 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/852610.

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Bone substitutes, like calcium phosphate, are implemented more frequently in orthopaedic surgery to reconstruct critical size defects, since autograft often results in donor site morbidity and allograft can transmit diseases. A novel bone cement, based onβ-tricalcium phosphate, polyethylene glycol, and trisodium citrate, was developed to allow the rapid manufacturing of scaffolds, by extrusion freeform fabrication, at room temperature. The cement composition exhibits good resorption properties and serves as a basis for customised (e.g., drug or growth factor loaded) scaffolds for critical size
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Dissertations / Theses on the topic "Scaffold Bone Defect"

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Lui, Yuk-fai, and 呂旭輝. "Evaluation of porous polyurethane scaffold on facilitating healing in critical sized bone defect." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B49858865.

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Bone graft substitute is a continuously developing field in orthopedics. When compared to tradition biomaterial in the field such as PLA or PCL, elastomer like polyurethane offers advantages in its high elasticity and flexibility, which establish an intimate contact with surrounding bones. This tight contact can provide a stable bone-material interface for cell proliferation and ingrowth of bone. The aim of this study is to evaluate the osteogenesis capabilities of a porous polyurethane scaffold in a critical size bone defect. In this study, a porous scaffold synthesized from segmented polyur
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Wojtowicz, Abigail M. "Genetically-engineered bone marrow stromal cells and collagen mimetic scaffold modification for healing critically-sized bone defects." Diss., Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/34705.

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Non-healing bone defects have a significant socioeconomic impact in the U.S. with approximately 600,000 bone grafting procedures performed annually. Autografts and allografts are clinically the most common treatments; however, autologous donor bone is in limited supply, and allografts often have poor mechanical properties. Therefore, tissue engineering and regenerative medicine strategies are being developed to address issues with clinical bone grafting. The overall objective of this work was to develop bone tissue engineering strategies that enhance healing of orthotopic defects by targeti
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Hart, Amanda Peter. "BONE ENGINEERING OF THE ULNA OF RABBIT." UKnowledge, 2005. http://uknowledge.uky.edu/gradschool_theses/199.

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Repair of bone defects is a major challenge in orthopaedic surgery. Current bone graft treatments, including autografts, allografts and xenografts, have many limitations making it necessary to develop a biomaterial to be a bone graft substitute. One such biomaterial is bioactive resorbable silica-calcium phosphate nanocomposite (SCPC). SCPC was processed using a 3D rapid prototyping technique and sintered at different temperatures to create porous scaffolds. SEM analyses and mercury intrusion porosimetry showed SCPC to be highly porous with micro- and nanopores. BET analysis indicated that SCP
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Blomberger, Daniela. "Development of a novel Voronoi structured scaffold for critical-size bone defects." Thesis, Queensland University of Technology, 2020. https://eprints.qut.edu.au/206168/1/Daniela_Blomberger_Thesis.pdf.

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Over the last decade, technological development has led to a revolution in the treatment of bone injuries. Few technologies hold more promise than 3D printing of biological material, which includes the field of bone science. This dissertation focused on 3D printed biodegradable scaffolds by using a novel Voronoy structured scaffold for critical-size bone defects that follows the definitions defined by mathematician Georgy Voronoy. These offer innovative healing opportunities for patients experiencing large bone defects, induced either by accidental or pathological causes, to regenerate the dam
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Reichert, Johannes Christian. "Tissue engineering bone - reconstruction of critical sized segmental bone defects in a large animal model." Thesis, Queensland University of Technology, 2010. https://eprints.qut.edu.au/48080/1/Johannes_Reichert_Thesis.pdf.

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Currently, well established clinical therapeutic approaches for bone reconstruction are restricted to the transplantation of autografts and allografts, and the implantation of metal devices or ceramic-based implants to assist bone regeneration. Bone grafts possess osteoconductive and osteoinductive properties, their application, however, is associated with disadvantages. These include limited access and availability, donor site morbidity and haemorrhage, increased risk of infection, and insufficient transplant integration. As a result, recent research focuses on the development of complementar
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Henkel, Jan. "Bone tissue engineering in two preclinical ovine animal models." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/109909/1/Jan_Henkel_Thesis.pdf.

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This PhD-research was focused on the development and evaluation of innovative scaffold-based bone tissue engineering concepts for the treatment of large volume bone defects, which still represent a major challenge in orthopaedic and reconstructive surgery. Two different types of bone tissue engineering constructs were investigated and successfully applied to regenerate critically-sized segmental bone defects in ovine animal models. The results outlined in the PhD thesis represent a significant contribution to potential future clinical translations of bone tissue engineering concepts from bench
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Heidarkhan, Tehrani Ashkan. "Exploring methods of preparing functional cartilage-bone xenografts for joint repair." Thesis, Queensland University of Technology, 2015. https://eprints.qut.edu.au/90556/1/Ashkan_Heidarkhan%20Tehrani_Thesis.pdf.

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This thesis explores the feasibility of donor-receiver concept for joint replacement where cartilage-bone tissues can be taken from either human or other mammals and prepared scientifically for repairing focal joint defects in knees, hips and shoulders. The manufactured construct is immunologically inert and is capable of acting as a scaffold for engineering new cartilage-bone laminates when placed in the joint. Innovative manufacturing procedures and assessment techniques were developed for appraising this tissue-based scaffold. This research has demonstrated that tissue replacement technolog
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Tim, Carla Roberta. "Efeitos do laser de baixa intensidade e do Scaffold de Biosilicato® no processo de reparação óssea." Universidade Federal de São Carlos, 2011. https://repositorio.ufscar.br/handle/ufscar/6973.

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Made available in DSpace on 2016-08-17T18:39:36Z (GMT). No. of bitstreams: 1 3621.pdf: 12488772 bytes, checksum: 3b893af6e3b0ea869fd5eda12f270c8a (MD5) Previous issue date: 2011-02-24<br>Financiadora de Estudos e Projetos<br>Several resources have been studied in order to accelerate the process of bone repair. Among these resources, bioactive materials and low level laser therapy (LLLT) have gained prominence. Several studies suggest that both resources are able of stimulating osteoblast proliferation and osteogenesis at the fracture site, promoting a greater deposition of bone mass, which i
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Jones, Brendan John. "Reconstruction of critical-sized ovine mandibular defects - a pilot study." Thesis, Queensland University of Technology, 2014. https://eprints.qut.edu.au/72238/1/Brendan_Jones_Thesis.pdf.

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Establishing the sheep model for translational research of mandible (jaw) segmental defect regeneration. Providing a framework from which additional experimentation and evaluation of novel tissue engineered constructs may be undertaken, compared and collated. For current and future novel approaches to mandible segmental defect reconstruction that may be transferable to the human condition and, ultimately, the operative table.
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Rentsch, Claudia, Wolfgang Schneiders, Ricarda Hess, et al. "Healing properties of surface-coated polycaprolactone-co-lactide scaffolds: A pilot study in sheep." Sage, 2014. https://tud.qucosa.de/id/qucosa%3A35693.

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The aim of this pilot study was to evaluate the bioactive, surface-coated polycaprolactone-co-lactide scaffolds as bone implants in a tibia critical size defect model. Polycaprolactone-co-lactide scaffolds were coated with collagen type I and chondroitin sulfate and 30 piled up polycaprolactone-co-lactide scaffolds were implanted into a 3 cm sheep tibia critical size defect for 3 or 12 months (n¼5 each). Bone healing was estimated by quantification of bone volume in the defects on computer tomography and microcomputer tomography scans, plain radiographs, biomechanical testing as well as by his
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Books on the topic "Scaffold Bone Defect"

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Goldberg, Cory S. Bone engineering in a rabbit craniotomy defect using a composite biodegradable scaffold. National Library of Canada, 2003.

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Book chapters on the topic "Scaffold Bone Defect"

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Yoon, Sun Jung, Ki Suk Park, Bang Sil Choi, et al. "Effect of DBP/PLGA Hybrid Scaffold on Angiogenesis during the Repair of Calvarial Bone Defect." In Advanced Biomaterials VII. Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-436-7.161.

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Abdullah, Amira Raudhah, and Intan Maslina Musa. "Establishment of Femoral Bone Defect Model in Sprague-Dawley Rat for Engineered Scaffold Implantation: A Pilot Study." In IFMBE Proceedings. Springer Nature Switzerland, 2024. http://dx.doi.org/10.1007/978-3-031-61628-0_3.

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Min, D. H., M. J. Kim, J. H. Yun, et al. "Effect of Calcium Phosphate Glass Scaffold with Chitosan Membrane on the Healing of Alveolar Bone in 1 Wall Intrabony Defect in the Beagle Dogs." In Bioceramics 17. Trans Tech Publications Ltd., 2005. http://dx.doi.org/10.4028/0-87849-961-x.851.

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Daskalakis, Evangelos, Enes Aslan, Fengyuan Liu, et al. "Composite Scaffolds for Large Bone Defects." In Lecture Notes in Mechanical Engineering. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-29041-2_31.

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Metzelder, M. L., and G. H. Willital. "Defekt-Auffüllung mit VITOSS Bone-Scaffold bei zystischen Knochenveränderungen im Kindesalter." In Zurück in die Zukunft. Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-642-55611-1_484.

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Pavesio, Alessandra, Giovanni Abatangelo, Anna Borrione, et al. "Hyaluronan-Based Scaffolds (Hyalograft® C) in the Treatment of Knee Cartilage Defects: Preliminary Clinical Findings." In Tissue Engineering of Cartilage and Bone. John Wiley & Sons, Ltd, 2008. http://dx.doi.org/10.1002/0470867973.ch15.

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Alshammari, Adel, Fahad Alabdah, Lipeng Song, and Glen Cooper. "Computational Analysis of Large Bone Defect Healing Using Bone Tissue Scaffolds, Degradation, and Growth Factor Delivery: A Mechanobiological Model of Bone Tissue Formation." In IFMBE Proceedings. Springer Nature Switzerland, 2024. http://dx.doi.org/10.1007/978-3-031-61625-9_25.

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Park, Min Sung, Young Mee Jung, Soo Hyun Kim, et al. "Regeneration of Bone Defect Using Micro-Bioceramic PLLA Polymer Scaffolds Synthesized by Nonsolvent and Solvent Method." In Advanced Biomaterials VII. Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-436-7.145.

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Rajkumar, Abhishek Verma, Anupam Yadav, Janakarajan Ramkumar, and Kantesh Balani. "Finite Element Analysis on the Biomechanical Stability of TPMS-Based Scaffolds for Large Segmental Femur Bone Defect." In Springer Proceedings in Materials. Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-97-5963-7_30.

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Rahaman, Mohamed N., Yinan Lin, Wei Xiao, X. Liu, and B. Sonny Bal. "Evaluation of Long-Term Bone Regeneration in Rat Calvarial Defects Implanted With Strong Porous Bioactive Glass (13-93) Scaffolds." In Ceramic Transactions Series. John Wiley & Sons, Inc., 2015. http://dx.doi.org/10.1002/9781119190134.ch9.

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Conference papers on the topic "Scaffold Bone Defect"

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Cheng, XingGuo, Sapna Desai, Gloria Gutierrez, et al. "Promising Biological Performance of Biodegradable 3D Coated Mg Alloy Bone Scaffold." In CORROSION 2012. NACE International, 2012. https://doi.org/10.5006/c2012-01178.

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Abstract Mg alloy in the solid monolith forms has been investigated as a promising orthopedic implant. Different coating techniques have also been developed to control the bio-corrosion and improve the biocompatibility. In the current study, we design novel 3D Mg alloy scaffolds by rolling thin stiff sheets into hollow cylindrical scaffolds. Such designed scaffolds mimic the basic shape of the cortical bone while reduce the amount of alloy used. These scaffolds were further coated with biocompatible coatings to improve the biocompatiblity. Finally, they were tested in vitro using mesenchymal s
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Russo, Alessandro, Silvia Panseri, Tatiana Shelyakova, et al. "Critical Long Bone Defect Treated by Magnetic Scaffolds and Fixed by Permanent Magnets." In ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/nemb2013-93193.

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Diaphyseal bone defect represents a significant problem for orthopaedic surgeons and patients. In order to improve and fasten bone regenerating process we implanted HA biodegradable magnetized scaffolds in a large animal model critical bone defect. A critical long bone defect was created in 6 sheep metatarsus diaphysis; then we implanted a novel porous ceramic composite scaffold (20.0 mm in length; 6.00 mm inner diameter and 17.00 mm outer diameter), made of Hydroxyapatite that incorporates magnetite (HA/Mgn 90/10), proximally fixated by two small cylindrical permanent parylene coated NdFeB ma
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Yanoso, Laura, Justin Jacobson, Tulin Dadali, David Reynolds, and Hani Awad. "Evaluation of Polylactic Acid/Beta-Tricalcium Phosphate Scaffolds as Segmental Bone Graft Substitutes." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192978.

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The use of processed structural allografts for treatment of massive segmental defects in long bones can be complicated by poor incorporation and remodeling of the devitalized graft, foreign-body reaction and micro-damage accumulation which often leads to catastrophic graft failure [1]. It is therefore useful to develop a bioengineered, biodegradable scaffold that is able to stimulate healing of the defect region. The use of bioengineered scaffolds has been limited due to their poor mechanical strength that does not permit withstanding large in vivo loads and due to their poor osteoinductive pr
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Gupta, Akash, Kyung Chil Chung, Ryan J. Quigley, Bong Jae Jun, and Thay Q. Lee. "Evaluation of Scaffold Fixation for Treatment of Osteochondral Defects of the Knee." In ASME 2010 5th Frontiers in Biomedical Devices Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/biomed2010-32050.

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Articular cartilage damage is a common source of knee pain that can be treated with autologous chondrocyte implantation (ACI). Fixation of the scaffolds can be accomplished by various means with bone sutures being the most effective. The purpose of this study was to evaluate the fixation of a new scaffold with three bone sutures after cycling with continuous passive motion (CPM). Two defects, each of 20mm diameter and 5mm depth, were created per knee and the scaffold was fixed with three bone sutures at the 12 o’clock, 4 o’clock and 8 o’clock positions. Knees were then cycled from 0 degrees to
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Lu, Lin, David Wootton, Peter I. Lelkes, and Jack Zhou. "Bone Scaffold Fabrication System Study." In ASME 2007 International Manufacturing Science and Engineering Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/msec2007-31219.

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Musculoskeletal conditions are a major health concern in United States because of a large aging population and increased occurrence of sport-related injuries. The need for bone substitutes is especially important. Traditional treatments of bone-defect have many limitations. Bone tissue engineering may offer a less painful alternative to traditional bone grafts with lower risk of infection. This research integrates biomimetic modeling, solid freedom fabrication (SFF), systems and control, and tissue engineering in one intelligent system for structured, highly porous biomaterials, which will be
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Cohen, David O., Sohaila M. G. Aboutaleb, Amy Wagoner Johnson, and Julian A. Norato. "Computational Design of Additively Manufactured Curvilinear Scaffolds for Bone Repair." In ASME 2022 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2022. http://dx.doi.org/10.1115/detc2022-90582.

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Abstract This work introduces a computational method for designing ceramic scaffolds fabricated via direct ink writing (DIW) for maximum bone growth, whereby the deposited rods are curvilinear. A mechanobiological model of bone adaptation is used to compute bone growth into the scaffold, taking into account the shape of the defect, the applied loading, and the density distribution of bone in which the scaffold is implanted. The method ensures smooth, continuously varying rod contours are produced which are ideal for the DIW process. The method uses level sets of radial basis functions to fully
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Lu, Lin, Robert S. Dembzynski, Mark J. Mondrinos, David Wootton, Peter I. Lelkes, and Jack Zhou. "Manufacturing System Development for Fabrication of Bone Scaffold." In ASME 2005 International Mechanical Engineering Congress and Exposition. ASMEDC, 2005. http://dx.doi.org/10.1115/imece2005-80937.

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Musculoskeletal conditions are a major health concern in United States because of a large aging population and increased occurrence of sport-related injuries. The need for bone substitutes is especially important. Traditional treatments of bone-defect have many of limitations. Bone tissue engineering may offer a less painful alternative to traditional bone grafts with lower risk of infection. This research integrates biomimetic modeling, solid freeform fabrication (SFF), systems and control, and tissue engineering in one intelligent system for structured, highly porous biomaterials, which will
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Abdelgaber, Yousef, Cole Klemstine, Logan Lawrence, James B. Day, Pier Paolo Claudio, and Roozbeh (Ross) Salary. "A Novel Image-Based Method for In Situ Characterization of the Pore Size Distribution and Dimensional Accuracy of Bone Tissue Scaffolds." In ASME 2021 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/imece2021-72132.

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Abstract Pneumatic micro-extrusion (PME) is a high-resolution direct-write additive manufacturing method, which has been widely utilized for the fabrication of biological tissues, structures, and organs. The PME process allows for non-contact, multi-material deposition of a wide range of functional bio-inks for tissue engineering applications. However, the PME process is inherently complex, governed by complex multi-physics phenomena. Consequently, investigation of the effects of significant process parameters and their interactions on scaffold functional properties would be inevitable. The ov
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Bai, Xueling, Peng Ding, Peng Zhang, and Zhidong Yao. "Research on Modeling of Bionic Porous Scaffold for Bone Defect Repair Based on Bone Mineral Density Distribution." In 2018 International Conference on Computer Modeling, Simulation and Algorithm (CMSA 2018). Atlantis Press, 2018. http://dx.doi.org/10.2991/cmsa-18.2018.8.

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Hayward, Lauren N. M., and Elise F. Morgan. "Mechano-Regulation of Stem Cell Differentiation During Bending Stimulation of a Healing Bone Defect." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192981.

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Abstract:
Mechanical stimulation of a bone fracture can alter the course of tissue differentiation [1]. Quantitative characterization of this mechano-regulatory effect has great therapeutic potential. For example, mechano-regulation theories are already being applied to tailor scaffold designs in tissue engineering applications [2]. Approaches such as these may lead to improved treatment of bone and joint degeneration as well as treatment of orthopedic injuries.
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Reports on the topic "Scaffold Bone Defect"

1

Pilia, Marcello, Teja Guda, and Mark Appleford. Development of Composite Scaffolds for Load Bearing Segmental Bone Defects. Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada616641.

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