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Journal articles on the topic 'Scaffold Bone Defect'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Kim, Jong Min, Jun Sik Son, Seong Soo Kang, Gonhyung Kim, and Seok Hwa Choi. "Bone Regeneration of Hydroxyapatite/Alumina Bilayered Scaffold with 3 mm Passage-Like Medullary Canal in Canine Tibia Model." BioMed Research International 2015 (2015): 1–6. http://dx.doi.org/10.1155/2015/235108.

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The aim of this study was to evaluate the bone regeneration of hydroxyapatite (HA)/alumina bilayered scaffold with a 3 mm passage-like medullary canal in a beagle tibia model. A porous HA/alumina scaffold was fabricated using a polymeric template-coating technique. HA/alumina scaffold dimensions were 10 mm in outer diameter, 20 mm in length, and with either a 3 mm passage or no passage. A 20 mm segmental defect was induced using an oscillating saw through the diaphysis of the beagle tibia. The defects of six beagles were filled with HA/alumina bilayered scaffolds with a 3 mm passage or without

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Fang, Yifei, Yong Gong, Zhijian Yang, and Yan Chen. "Repair of Osteoporotic Bone Defects Using Adipose-Derived Stromal Cells and Umbilical Vein Endothelial Cells Seeded in Chitosan/Nanohydroxyapatite-P24 Nanocomposite Scaffolds." Journal of Nanomaterials 2021 (August 21, 2021): 1–11. http://dx.doi.org/10.1155/2021/6237130.

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Background. The cell regeneration and blood supply of bone defect lesions are restricted under osteoporotic pathological conditions, which make the healing of bone defect of osteoporosis still a great challenge. The current therapeutic strategies that mainly inhibit bone resorption are not always satisfactory for osteoporotic bone defects, which make the development of new therapies an urgent need. Methods. Previously, we prepared chitosan/nanohydroxyapatite (CS/nHA) biomimetic nanocomposite scaffolds for controlled delivery of bone morphogenetic protein 2-derived peptide (P24). In this study,

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Kessler, Franziska, Kevin Arnke, Benjamin Eggerschwiler, et al. "Murine iPSC-Loaded Scaffold Grafts Improve Bone Regeneration in Critical-Size Bone Defects." International Journal of Molecular Sciences 25, no. 10 (2024): 5555. http://dx.doi.org/10.3390/ijms25105555.

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In certain situations, bones do not heal completely after fracturing. One of these situations is a critical-size bone defect where the bone cannot heal spontaneously. In such a case, complex fracture treatment over a long period of time is required, which carries a relevant risk of complications. The common methods used, such as autologous and allogeneic grafts, do not always lead to successful treatment results. Current approaches to increasing bone formation to bridge the gap include the application of stem cells on the fracture side. While most studies investigated the use of mesenchymal st

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Li, Ming, Jianheng Liu, Xiang Cui, et al. "Osteogenesis effects of magnetic nanoparticles modified-porous scaffolds for the reconstruction of bone defect after bone tumor resection." Regenerative Biomaterials 6, no. 6 (2019): 373–81. http://dx.doi.org/10.1093/rb/rbz019.

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Abstract The treatment of bone defect after bone tumor resection is a great challenge for orthopedic surgeons. It should consider that not only to inhibit tumor growth and recurrence, but also to repair the defect and preserve the limb function. Hence, it is necessary to find an ideal functional biomaterial that can repair bone defects and inactivate tumor. Magnetic nanoparticles (MNPs) have its unique advantages to achieve targeted hyperthermia to avoid damage to surrounding normal tissues and promote osteoblastic activity and bone formation. Based on the previous stage, we successfully prepa

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Zhou, Shuai, Shihang Liu, Yan Wang, et al. "Advances in the Study of Bionic Mineralized Collagen, PLGA, Magnesium Ionomer Materials, and Their Composite Scaffolds for Bone Defect Treatment." Journal of Functional Biomaterials 14, no. 8 (2023): 406. http://dx.doi.org/10.3390/jfb14080406.

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The healing of bone defects after a fracture remains a key issue to be addressed. Globally, more than 20 million patients experience bone defects annually. Among all artificial bone repair materials that can aid healing, implantable scaffolds made from a mineralized collagen (MC) base have the strongest bionic properties. The MC/PLGA scaffold, created by adding Poly (lactic-co-glycolic acid) copolymer (PLGA) and magnesium metal to the MC substrate, plays a powerful role in promoting fracture healing because, on the one hand, it has good biocompatibility similar to that of MC; on the other hand

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Lim, Jin Xi, Min He, and Alphonsus Khin Sze Chong. "3D-printed Poly-Lactic Co-Glycolic Acid (PLGA) scaffolds in non-critical bone defects impede bone regeneration in rabbit tibia bone." Bio-Medical Materials and Engineering 32, no. 6 (2021): 375–81. http://dx.doi.org/10.3233/bme-216017.

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BACKGROUND: An increasing number of bone graft materials are commercially available and vary in their composition, mechanism of action, costs, and indications. OBJECTIVE: A commercially available PLGA scaffold produced using 3D printing technology has been used to promote the preservation of the alveolar socket after tooth extraction. We examined its influence on bone regeneration in long bones of New Zealand White rabbits. METHODS: 5.0-mm-diameter circular defects were created on the tibia bones of eight rabbits. Two groups were studied: (1) control group, in which the bone defects were left

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Kim, You Min, Min-Soo Ghim, Meiling Quan, Young Yul Kim, and Young-Sam Cho. "Experimental Verification of the Impact of the Contact Area between the Defect Site and the Scaffold on Bone Regeneration Efficacy." Polymers 16, no. 3 (2024): 338. http://dx.doi.org/10.3390/polym16030338.

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In the field of bone tissue engineering, which is being developed for the ideal restoration of bone defects, researchers are exploring the improvement of the bone regeneration efficacy of scaffolds through various approaches involving osteoconductive, osteoinductive, and angiogenic factors. In the current trend of research, there is also a suggestion that the topological factors of recent scaffolds may influence the attachment, migration, proliferation, and differentiation of bone cells. Building upon experimental confirmation of the effect of scaffold conformity with the defect site on enhanc

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Chen, Shuang S., Ophir Ortiz, Alexandra K. Pastino, et al. "Hybrid Bone Scaffold Induces Bone Bridging in Goat Calvarial Critical Size Defects Without Growth Factor Augmentation." Regenerative Engineering and Translational Medicine 6, no. 2 (2020): 189–200. http://dx.doi.org/10.1007/s40883-019-00144-z.

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Abstract In the present study, a series of four different scaffolds were comparatively evaluated in a goat calvarial critical size defect model. Such studies are only rarely reported in the literature. In our work, E1001(1k), a member of a large combinational library of tyrosine-derived polycarbonates (TyrPC), was used to prepare two calcium phosphate hybrid, biodegradable bone scaffolds. In one formulation, the widely used β-tricalcium phosphate (β-TCP) was incorporated into the polymer scaffold. In the second formulation, a coating of dicalcium phosphate dihydrate (DCPD, also known as brushi

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Mi, Xue, Zhenya Su, Yu Fu, Shiqi Li, and Anchun Mo. "3D printing of Ti₃C₂-MXene-incorporated composite scaffolds for accelerated bone regeneration." Biomedical Materials 17, no. 3 (2022): 035002. http://dx.doi.org/10.1088/1748-605x/ac5ffe.

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Abstract Grafting of bone-substitute biomaterials plays a vital role in the reconstruction of bone defects. However, the design of bioscaffolds with osteoinductive agents and biomimetic structures for regeneration of critical-sized bone defects is difficult. Ti3C2 MXene—belonging to a new class of 2D nanomaterials—exhibits excellent biocompatibility, and antibacterial properties, and promotes osteogenesis. However, its application in preparing 3D-printed tissue-engineered bone scaffolds for repairing bone defects has not been explored. In this work, Ti3C2 MXene was incorporated into composite

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Bergmann, Christian J. D., Jim C. E. Odekerken, Tim J. M. Welting, et al. "Calcium Phosphate Based Three-Dimensional Cold Plotted Bone Scaffolds for Critical Size Bone Defects." BioMed Research International 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/852610.

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Bone substitutes, like calcium phosphate, are implemented more frequently in orthopaedic surgery to reconstruct critical size defects, since autograft often results in donor site morbidity and allograft can transmit diseases. A novel bone cement, based onβ-tricalcium phosphate, polyethylene glycol, and trisodium citrate, was developed to allow the rapid manufacturing of scaffolds, by extrusion freeform fabrication, at room temperature. The cement composition exhibits good resorption properties and serves as a basis for customised (e.g., drug or growth factor loaded) scaffolds for critical size

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Canciani, Elena, Paola Straticò, Vincenzo Varasano, et al. "Polylevolysine and Fibronectin-Loaded Nano-Hydroxyapatite/PGLA/Dextran-Based Scaffolds for Improving Bone Regeneration: A Histomorphometric in Animal Study." International Journal of Molecular Sciences 24, no. 9 (2023): 8137. http://dx.doi.org/10.3390/ijms24098137.

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The regeneration of large bone defects is still demanding, requiring biocompatible scaffolds, with osteoconductive and osteoinductive properties. This study aimed to assess the pre-clinical efficacy of a nano-hydroxyapatite (nano-HA)/PGLA/dextran-based scaffold loaded with Polylevolysine (PLL) and fibronectin (FN), intended for bone regeneration of a critical-size tibial defect, using an ovine model. After physicochemical characterization, the scaffolds were implanted in vivo, producing two monocortical defects on both tibiae of ten adult sheep, randomly divided into two groups to be euthanize

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Semyari, Hossein, Majid Salehi, Ferial Taleghani, et al. "Fabrication and characterization of collagen–hydroxyapatite-based composite scaffolds containing doxycycline via freeze-casting method for bone tissue engineering." Journal of Biomaterials Applications 33, no. 4 (2018): 501–13. http://dx.doi.org/10.1177/0885328218805229.

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In this study, hydroxyapatite nanoparticles containing 10% doxycycline, a structural isomer of tetracycline, was prepared by the co-precipitation method. It was added to collagen solution for the preparation of the scaffold with freeze-casting method in order to develop a composite scaffold with both antibacterial and osteoinductive properties for repairing bone defects. The scaffolds were evaluated regarding their morphology, porosity, degradation and cellular response. The scaffolds for further investigation were added in a rat calvaria defect model. The study showed that after eight weeks,

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Yun, JW, SY Heo, MH Lee, and HB Lee. "Evaluation of a poly(lactic-acid) scaffold filled with poly(lactide-co-glycolide)/hydroxyapatite nanofibres for reconstruction of a segmental bone defect in a canine model." Veterinární Medicína 64, No. 12 (2019): 531–38. http://dx.doi.org/10.17221/80/2019-vetmed.

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Critical-sized bone defects are a difficult problem in both human and veterinary medicine. To address this issue, synthetic graft materials have been garnering attention. Abundant in vitro studies have proven the possibilities of poly(lactic-acid) (PLA) scaffolds and poly(lactide-co-glycolide)/hydroxyapatite (PLGA/HAp) nanofibres for treating bone defects. The present study aimed at conducting an in vivo assessment of the biological performance of a three dimensional (3D)-printed PLA scaffold filled with a PLGA/HAp nanofibrous scaffold to estimate its potential applications in bone defect reco

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Ronca, Alfredo, Vincenzo Guarino, Maria Grazia Raucci, et al. "Large defect-tailored composite scaffolds for in vivo bone regeneration." Journal of Biomaterials Applications 29, no. 5 (2014): 715–27. http://dx.doi.org/10.1177/0885328214539823.

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The discovery of new strategies to repair large segmental bone defects is currently an open challenge for worldwide clinicians. In the treatment of critical-sized bone defects, an alternative strategy to traditional bone grafting is always more frequently the use of tailor-made scaffolds modelled on the final size and shape of the implant site. Here, poly-ε-caprolactone-based composite scaffolds including poly-l-lactic acid continuous fibres and hyaluronan derivates (i.e. HYAFF11®) have been investigated for the peculiar 3D architecture characterized by interconnected macroporous networks and

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Vigni, Giulio Edoardo, Mariano Licciardi, Lorenzo D’itri, et al. "Improved Bone Regeneration Using Biodegradable Polybutylene Succinate Artificial Scaffold with BMP-2 Protein in a Rabbit Model." Materials 18, no. 10 (2025): 2234. https://doi.org/10.3390/ma18102234.

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Extensive bone loss represents a great challenge for orthopedic and reconstructive surgery. On an in vivo rabbit model, the healing of two bone defects on a long bone, tibia, was studied. A polybutylene succinate (PBS) microfibrillar scaffold was implemented with BMP-2 protein and hydroxyapatite (HA) as potential osteogenic factors. The present study was carried out on 6 male New Zealand white (4–6 months old) rabbits in vivo model. One bone defect was created in each subject on the tibia. The controls were left to heal spontaneously while the study samples were treated with the polybutylene s

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Schlichting, Karin, Hanna Schell, Ralf U. Kleemann, et al. "Influence of Scaffold Stiffness on Subchondral Bone and Subsequent Cartilage Regeneration in an Ovine Model of Osteochondral Defect Healing." American Journal of Sports Medicine 36, no. 12 (2008): 2379–91. http://dx.doi.org/10.1177/0363546508322899.

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Background In osteochondral defects, subchondral bone, as a load-bearing structure, is believed to be important for bone and cartilage regeneration. Hypothesis A stiff scaffold creates better conditions for bone formation and cartilage regeneration than does a softer one. Study Design Controlled laboratory study. Methods Critical osteochondral defects were created in the femoral condyles of 24 sheep. Subchondral bone was reconstructed with a stiff scaffold or a modified softer one, with untreated defects serving as controls. The repair response was evaluated with mechanical, histological, and

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Wang, Wenzhao, Boqing Zhang, Lihong Zhao, et al. "Fabrication and properties of PLA/nano-HA composite scaffolds with balanced mechanical properties and biological functions for bone tissue engineering application." Nanotechnology Reviews 10, no. 1 (2021): 1359–73. http://dx.doi.org/10.1515/ntrev-2021-0083.

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Abstract Repair of critical bone defects is a challenge in the orthopedic clinic. 3D printing is an advanced personalized manufacturing technology that can accurately shape internal structures and external contours. In this study, the composite scaffolds of polylactic acid (PLA) and nano-hydroxyapatite (n-HA) were manufactured by the fused deposition modeling (FDM) technique. Equal mass PLA and n-HA were uniformly mixed to simulate the organic and inorganic phases of natural bone. The suitability of the composite scaffolds was evaluated by material characterization, mechanical property, and in

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Shah, Sarav S., Haixiang Liang, Sandeep Pandit, et al. "Optimization of Degradation Profile for New Scaffold in Cartilage Repair." CARTILAGE 9, no. 4 (2017): 438–49. http://dx.doi.org/10.1177/1947603517700954.

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Objective To establish whether a novel biomaterial scaffold with tunable degradation profile will aid in cartilage repair of chondral defects versus microfracture alone in vitro and in a rat model in vivo. Design In vitro—Short- and long-term degradation scaffolds were seeded with culture expanded articular chondrocytes or bone marrow mesenchymal stem cells. Cell growth and differentiation were evaluated with cell morphological studies and gene expression studies. In vivo—A microfracture rat model was used in this study to evaluate the repair of cartilage and subchondral bone with the contrala

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Sithole, Mduduzi N., Pradeep Kumar, Lisa C. Du Toit, Kennedy H. Erlwanger, Philemon N. Ubanako, and Yahya E. Choonara. "A 3D-Printed Biomaterial Scaffold Reinforced with Inorganic Fillers for Bone Tissue Engineering: In Vitro Assessment and In Vivo Animal Studies." International Journal of Molecular Sciences 24, no. 8 (2023): 7611. http://dx.doi.org/10.3390/ijms24087611.

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This research aimed to substantiate the potential practicality of utilizing a matrix-like platform, a novel 3D-printed biomaterial scaffold, to enhance and guide host cells’ growth for bone tissue regeneration. The 3D biomaterial scaffold was successfully printed using a 3D Bioplotter® (EnvisionTEC, GmBH) and characterized. Osteoblast-like MG63 cells were utilized to culture the novel printed scaffold over a period of 1, 3, and 7 days. Cell adhesion and surface morphology were examined using scanning electron microscopy (SEM) and optical microscopy, while cell viability was determined using MT

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Charbonnier, B., L. Guyon, N. Touya, et al. "MECHANICALLY EVOLUTIVE 3D-PRINTED SCAFFOLDS FOR BONE REGENERATION." Orthopaedic Proceedings 106-B, SUPP_1 (2024): 63. http://dx.doi.org/10.1302/1358-992x.2024.1.063.

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Developments in the field of additive manufacturing have allowed significant improvements in the design and production of scaffolds with biologically relevant features to treat bone defects. Unfortunately, the workflow to generate personalized scaffolds is source of inaccuracies leading to a poor fit between the implant and patients' bone defects. In addition, scaffolds are often brittle and fragile, uneasing their handling by surgeons, with significant risks of fracture during their insertion in the defect. Consequently, we developed organo-mineral cementitious scaffolds displaying evolutive

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Peña, Gonzalo de la, Lorena Gallego, Luis M. Redondo, Luis Junquera, Javier F. Doval, and Álvaro Meana. "Comparative analysis of plasma-derived albumin scaffold, alveolar osteoblasts and synthetic membrane in critical mandibular bone defects: An experimental study on rats." Journal of Biomaterials Applications 36, no. 3 (2021): 481–91. http://dx.doi.org/10.1177/0885328221999824.

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Repair of bone deficiencies in the craniofacial skeleton remains a challenging clinical problem. The aim of this study was to evaluate and compare the effects of a plasma-derived albumin scaffold, alveolar osteoblasts and synthetic membrane implanted into experimental mandibular defects. Bilateral mandibular defects were created in twelve immunodeficient rats. The bone defect was filled with serum scaffold alone in left sides and scaffold combined with human alveolar osteoblast in right side defects. Implanted areas were closed directly in Group 1 ( n = 6) and covered by a resorbable polyglyco

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Wang, Xiaoyang, Shuqing Tong, Shengyun Huang, Li Ma, Zhenxing Liu, and Dongsheng Zhang. "Application of a New Type of Natural Calcined Bone Repair Material Combined with Concentrated Growth Factors in Bone Regeneration in Rabbit Critical-Sized Calvarial Defect." BioMed Research International 2020 (November 24, 2020): 1–6. http://dx.doi.org/10.1155/2020/8810747.

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Purpose. This study is aimed at investigating bone regeneration in critical-sized defects in rabbit calvarium using a novel nano- (n-) hydroxyapatite hybrid scaffold with concentrated growth factors (CGFs). Methods. Twenty-four male adult rabbits were chosen to establish a critical-sized bone defect model and randomly divided into two groups. Two defects of 15 mm diameter each were created in the parietal bone of each animal. Group A had n-hydroxyapatite hybrid scaffold placed in the experimental defect on the right, and the left defect was unfilled as blank. Group B had hydroxyapatite hybrid

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Gabor, Alin, Tiberiu Hosszu, Cristian Zaharia, et al. "3D Printing of a Mandibular Bone Deffect." Materiale Plastice 54, no. 1 (2017): 29–31. http://dx.doi.org/10.37358/mp.17.1.4778.

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The aim of this study was to achieve a polymeric scaffold, ex-vivo, using 3D printing technology and then subjecting it to various tests to check its optimal property. Initially there was selected a lower jaw with a bone defect that would have prevented any treatment based prosthetic implant. The mandible was first scanned using an optical scanner (MAESTRO DENTAL SCANNER MDS400). The scanning parameters using optical scanning system are: 10 micron accuracy, resolution 0.07 mm, 2 rooms with High-Resolution LED structured light, two axes. The scan time of the mandible was 4-5 min. Later the same

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Alonso-Fernández, Iván, Håvard Jostein Haugen, Liebert Parreiras Nogueira, et al. "Enhanced Bone Healing in Critical-Sized Rabbit Femoral Defects: Impact of Helical and Alternate Scaffold Architectures." Polymers 16, no. 9 (2024): 1243. http://dx.doi.org/10.3390/polym16091243.

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This study investigates the effect of scaffold architecture on bone regeneration, focusing on 3D-printed polylactic acid–bioceramic calcium phosphate (PLA-bioCaP) composite scaffolds in rabbit femoral condyle critical defects. We explored two distinct scaffold designs to assess their influence on bone healing and scaffold performance. Structures with alternate (0°/90°) and helical (0°/45°/90°/135°/180°) laydown patterns were manufactured with a 3D printer using a fused deposition modeling technique. The scaffolds were meticulously characterized for pore size, strut thickness, porosity, pore ac

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Unni, Ashok R., Syam K. Venugopal, K. D. John Martin, S. Anoop, S. Maya Maya та B. Dhanush Krishna. "Serum biochemical evaluation of healing of critical-sized long bone defects in rats treated with biphasic hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) bioceramic scaffolds". Journal of Veterinary and animal sciences 55, № 3 (2024): 586–92. http://dx.doi.org/10.51966/jvas.2024.55.3.586-592.

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Critical-sized long bone defects are those that would not heal spontaneously despite surgical stabilisation. The use of bioceramic scaffold has shown promising results in the repair of bone defects. The present study was undertaken to evaluate the serum biochemical parameters of Wistar rats treated for critical-sized segmental bone loss using biphasic hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) bioceramic scaffolds. The study was conducted in eighty male Wistar rats aged between 8-12 weeks, weighing 200-250 g body weight with critical-sized segmental defects in the femur. A 6 mm seg

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Lee, Ming-Chan, Cheng-Tang Pan, Wen-Fan Chen, Meng-Chi Lin, and Yow-Ling Shiue. "Design, Manufacture, and Characterization of a Critical-Sized Gradient Porosity Dual-Material Tibial Defect Scaffold." Bioengineering 11, no. 4 (2024): 308. http://dx.doi.org/10.3390/bioengineering11040308.

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This study proposed a composite tibia defect scaffold with radial gradient porosity, utilizing finite element analysis to assess stress in the tibial region with significant critical-sized defects. Simulations for scaffolds with different porosities were conducted, designing an optimal tibia defect scaffold with radial gradient porosity for repairing and replacing critical bone defects. Radial gradient porosity scaffolds resulted in a more uniform stress distribution, reducing titanium alloy stiffness and alleviating stress shielding effects. The scaffold was manufactured using selective laser

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Gani, Maria Apriliani, Aniek Setiya Budiatin, Dewi Wara Shinta, Chrismawan Ardianto, and Junaidi Khotib. "Bovine hydroxyapatite-based scaffold accelerated the inflammatory phase and bone growth in rats with bone defect." Journal of Applied Biomaterials & Functional Materials 21 (January 2023): 228080002211491. http://dx.doi.org/10.1177/22808000221149193.

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Hydroxyapatite (HA) is a biomaterial widely used to treat bone defect, such as due to traffic accident. The HA scaffold is obtained from synthetic HA or natural sources, such as bovine hydroxyapatite (BHA). This study aims to compare the characteristics and in vivo performance of BHA-based and HA-based scaffolds. For this purpose, the scaffold was formulated with gelatin (GEL) and characterised by SEM-EDX, FTIR and mini autograph. The defect model was carried out on the femur area of Wistar rats classified into three animal groups: defect, HA-GEL and BHA-GEL. Postoperatively (7, 14 and 28 days

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Dombrovskaya, Yu A., N. I. Enukashvili, R. E. Banashkov, N. Yu Semenova, I. A. Karabak, and A. V. Silin. "Prospects for the use of fibrin scaffolds populated with pulp and periodontal stem cells: an experimental study." Parodontologiya 26, no. 2 (2021): 96–103. http://dx.doi.org/10.33925/1683-3759-2021-26-2-96-103.

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Relevance. Creating three-dimensional scaffolds from biodegradable materials and seeding them with stem cells derived from the oral tissues is a promising tool for guided tissue regeneration. Pulp and periodontal stem cells have a high potential for osteogenic differentiation, which biologically determines their use in surgical bone reconstruction. The experiment shows the result of using fibrin glue seeded with pulp and periodontal stem cells on the mandible of laboratory mice. The article presents the results of computed tomography and histological examination. The data provide evidence of t

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Yoon, Sun Jung, Ki Suk Park, Bang Sil Choi, et al. "Effect of DBP/PLGA Hybrid Scaffold on Angiogenesis during the Repair of Calvarial Bone Defect." Key Engineering Materials 342-343 (July 2007): 161–64. http://dx.doi.org/10.4028/www.scientific.net/kem.342-343.161.

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This study was designed to investigate the influence of demineralized bone particles (DBP)/PLGA hybrid scaffold on angiogenesis and osteogenesis in a calvarial defect model. DBP/PLGA scaffolds were manufactured by solvent casting/salt leaching method, and each scaffold contained 0, 10, 20, 40, and 80 wt% DBP of PLGA, respectively. A total of 34 rats were operated and bicortical holes were placed on their calvaria. The defects were filled with different ratio DBP/PLGA scaffolds. After 3, 7, 14, and 28 days, specimens were taken and, histologic, immunohistologic and RT-PCR analyses were carried

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Weng, Weizong, Shaojun Song, Liehu Cao, et al. "A Comparative Study of Bioartificial Bone Tissue Poly-L-lactic Acid/Polycaprolactone and PLLA Scaffolds Applied in Bone Regeneration." Journal of Nanomaterials 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/935149.

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Bioartificial bone tissue engineering is an increasingly popular technique to repair bone defect caused by injury or disease. This study aimed to investigate the feasibility of PLLA/PCL (poly-L-lactic acid/polycaprolactone) by a comparison study of PLLA/PCL and PLLA scaffolds applied in bone regeneration. Thirty healthy mature New Zealand rabbits on which 15 mm distal ulna defect model had been established were selected and then were divided into three groups randomly: group A (repaired with PLLA scaffold), group B (repaired with PLLA/PCL scaffold), and group C (no scaffold) to evaluate the bo

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Verykokou, Styliani, Charalabos Ioannidis, Sofia Soile, et al. "The Role of Cone Beam Computed Tomography in Periodontology: From 3D Models of Periodontal Defects to 3D-Printed Scaffolds." Journal of Personalized Medicine 14, no. 2 (2024): 207. http://dx.doi.org/10.3390/jpm14020207.

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The treatment of osseous defects around teeth is a fundamental concern within the field of periodontology. Over the years, the method of grafting has been employed to treat bone defects, underscoring the necessity for custom-designed scaffolds that precisely match the anatomical intricacies of the bone cavity to be filled, preventing the formation of gaps that could allow the regeneration of soft tissues. In order to create such a patient-specific scaffold (bone graft), it is imperative to have a highly detailed 3D representation of the bone defect, so that the resulting scaffold aligns with t

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Lesci, Isidoro Giorgio, Leonardo Ciocca, Odila Mezini, and Norberto Roveri. "Synthetic Biomimetic HA Composite Scaffolds for the Bone Regenerative Medicine Using CAD-CAM Technology." Key Engineering Materials 672 (January 2016): 235–46. http://dx.doi.org/10.4028/www.scientific.net/kem.672.235.

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The study of nanocrystalline calcium phosphate physical-chemical characteristics and, thereafter, the possibility to imitate bone mineral for the development of new advanced biomaterials is constantly growing. The availability to use synthetic biomimetic hydroxylapatites (HA), since they are the most important inorganic constituents of hard tissues in vertebrates, represents a great turning point in bone tissue engineering because of their chemical similarity to the biological mineral component. The ability to control the architecture and strength of a bone tissue engineering scaffold is criti

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Cristescu, Ioan, Lucian Marina, Daniel Vilcioiu, F. Safta, M. Istodorescu, and A. Stere. "The Potential of Antibiotic Collagen Based Biocomposites for the Treatment of Bone Defects." Key Engineering Materials 587 (November 2013): 404–11. http://dx.doi.org/10.4028/www.scientific.net/kem.587.404.

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Antibiotic delivery systems used in the past have consisted primarily of impregnated cement beads that required routine removal once the antibiotic had eluded completely. With the development of collagen scaffolds that could be used to fill bony defects the antibiotic cold be delivered from the scaffold used to sustain local bone growth. Over the course of two years antibiotic loaded collagen scaffolds were used in the local treatment of 21patients suffering of complicated fractures including bone defects, infections or pseudoarthrosis, all of them of traumatic nature. At the time of the initi

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Zhu, Hong, Ziheng Lin, Qifei Luan, et al. "Angiogenesis-promoting composite TPMS bone tissue engineering scaffold for mandibular defect regeneration." International Journal of Bioprinting 10, no. 1 (2023): 0153. http://dx.doi.org/10.36922/ijb.0153.

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Mandibular defects severely impact the patient&rsquo;s quality of life and are difficult problems to treat in the clinical setting. Due to the limitations of current gold-standard therapies, there is a tremendous need for tissue engineering approaches to meet this rising clinical demand. Injectable platelet-rich fibrin (I-PRF) containing a variety of pro-regenerative growth factors and stromal cell-derived factor-1 (SDF-1) has been shown to be beneficial in stimulating angiogenesis. In this study, we developed a three-cycle minimally curved biomimetic bone tissue engineering scaffold made

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Fauzan, Fauzan. "Effect of Human Adipose-Derived Mesenchymal Stem Cell (HADMSC) With Chitosan Scaffold on Bone Defect White Rats (Rattus Norvegicus) on Serum Alkaline Phosphatase (ALP) Levels." Journal of Stem Cell Research and Tissue Engineering 6, no. 1 (2022): 39–47. http://dx.doi.org/10.20473/jscrte.v6i1.37514.

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Bone defect is one of the challenges for dentists in the process of healing bone tissue. Bone defect can occur in alveolar bone with the etiology of microorganisms and cyst expansion. In addition, cases of bone defects in alveolar bone are also often found in cases with treatment of apex resection and hemisection. Autologous bone graft is a clinical gold standard in the treatment of bone defect. However, the use of bone graft has a limited number of growth factors produced. Tissue engineering is the latest method in terms of bone regeneration. Tissue engineering has three main components; stem

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Chen, Chiu-Fang, Ya-Shuan Chou, Tzer-Min Lee, et al. "The Uniform Distribution of Hydroxyapatite in a Polyurethane Foam-Based Scaffold (PU/HAp) to Enhance Bone Repair in a Calvarial Defect Model." International Journal of Molecular Sciences 25, no. 12 (2024): 6440. http://dx.doi.org/10.3390/ijms25126440.

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Polyurethane (PU) is a promising material for addressing challenges in bone grafting. This study was designed to enhance the bone grafting capabilities of PU by integrating hydroxyapatite (HAp), which is known for its osteoconductive and osteoinductive potential. Moreover, a uniform distribution of HAp in the porous structure of PU increased the effectiveness of bone grafts. PEG/APTES-modified scaffolds were prepared through self-foaming reactions. A uniform pore structure was generated during the spontaneous foaming reaction, and HAp was uniformly distributed in the PU structure (PU15HAp and

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V., Sasi Kumar, Beeula A., Praveen Kumar та Naveen Kumar. "Inﬂuence of typographic biocomposite scaffold in facilitating biomineralization to progress complex hard tissue repair". BOHR Journal of Material Sciences and Engineering (BIJMSE) 1, № 1 (2023): 7–10. http://dx.doi.org/10.54646/bjmse.2023.02.

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Biomaterial modifications and scaffold fabrication methods in hard tissue engineering applications have seen enormous growth. However, clinical demand in treating and regenerating large bone defects is intricate, as current methods fail to meet requirements such as regenerating bone with optimal physical and mechanical properties in complex bone repair due to poor scaffold design and less bioactivity. To meet such clinical expectations, biomaterials are combined to create a 3D bone composite scaffold to improve the quality of the regenerated bone by improving bioactivity through biomineralizat

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Kumar, V. Sasi, A. Beeula, Praveen Kumar, and Naveen Kumar. "Influence of Typographic Biocomposite Scaffold in Facilitating Biomineralization to Progress Complex Hard Tissue Repair." BOHR International Journal of Material Sciences and Engineering 1, no. 1 (2022): 7–10. http://dx.doi.org/10.54646/bijmse.002.

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Biomaterial modifications and scaffold fabrication methods in hard tissue engineering applications have seen enormous growth. However, clinical demand in treating and regenerating large bone defects is intricate, as current methods fail to meet requirements such as regenerating bone with optimal physical and mechanical properties in complex bone repair due to poor scaffold design and less bioactivity. To meet such clinical expectations, biomaterials are combined to create a 3D bone composite scaffold to improve the quality of the regenerated bone by improving bioactivity through biomineralizat

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Hung, Kuo-Sheng, May-Show Chen, Wen-Chien Lan, et al. "Three-Dimensional Printing of a Hybrid Bioceramic and Biopolymer Porous Scaffold for Promoting Bone Regeneration Potential." Materials 15, no. 5 (2022): 1971. http://dx.doi.org/10.3390/ma15051971.

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In this study, we proposed a three-dimensional (3D) printed porous (termed as 3DPP) scaffold composed of bioceramic (beta-tricalcium phosphate (β-TCP)) and thermoreversible biopolymer (pluronic F-127 (PF127)) that may provide bone tissue ingrowth and loading support for bone defect treatment. The investigated scaffolds were printed in three different ranges of pore sizes for comparison (3DPP-1: 150–200 μm, 3DPP-2: 250–300 μm, and 3DPP-3: 300–350 μm). The material properties and biocompatibility of the 3DPP scaffolds were characterized using scanning electron microscopy, X-ray diffractometry, c

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Zhang, Wang, Fu, Ye, Wang, and Zhou. "Fabrication and Application of Novel Porous Scaffold in Situ-Loaded Graphene Oxide and Osteogenic Peptide by Cryogenic 3D Printing for Repairing Critical-Sized Bone Defect." Molecules 24, no. 9 (2019): 1669. http://dx.doi.org/10.3390/molecules24091669.

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Osteogenic peptides have been reported as highly effective in directing mesenchymal stem cell osteogenic differentiation in vitro and bone formation in vivo. Therefore, developing novel biomaterials for the controlled delivery of osteogenic peptides in scaffolds without lowering the peptide’s biological activity is highly desirable. To repair a critical-sized bone defect to efficiently achieve personalized bone regeneration, a novel bioactive poly(lactic-co-glycolic acid) (PLGA)/β-tricalcium phosphate (β-TCP) composite scaffold, in which graphene oxide (GO) and bone morphogenetic protein (BMP)

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Yang, Changsheng, Lei Zhou, Xiaodan Geng, Hui Zhang, Baolong Wang, and Bin Ning. "New dual-function in situ bone repair scaffolds promote osteogenesis and reduce infection." Journal of Biological Engineering 16, no. 1 (2022). http://dx.doi.org/10.1186/s13036-022-00302-y.

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Abstract Background The treatment of infectious bone defects is a difficult problem to be solved in the clinic. In situ bone defect repair scaffolds with anti-infection and osteogenic abilities can effectively deal with infectious bone defects. In this study, an in situ polycaprolactone (PCL) scaffold containing ampicillin (Amp) and Mg microspheres was prepared by 3D printing technology. Results Mg and Amp were evenly distributed in PCL scaffolds and could be released slowly to the surrounding defect sites with the degradation of scaffolds. In vitro experiments demonstrated that the PCL scaffo

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Jaber, Mahdi, Patrina S. P. Poh, Georg N. Duda, and Sara Checa. "PCL strut-like scaffolds appear superior to gyroid in terms of bone regeneration within a long bone large defect: An in silico study." Frontiers in Bioengineering and Biotechnology 10 (September 23, 2022). http://dx.doi.org/10.3389/fbioe.2022.995266.

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The treatment of large bone defects represents a major clinical challenge. 3D printed scaffolds appear as a promising strategy to support bone defect regeneration. The 3D design of such scaffolds impacts the healing path and thus defect regeneration potential. Among others, scaffold architecture has been shown to influence the healing outcome. Gyroid architecture, characterized by a zero mean surface curvature, has been discussed as a promising scaffold design for bone regeneration. However, whether gyroid scaffolds are favourable for bone regeneration in large bone defects over traditional st

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Liu, Bingchuan, Guojin Hou, Zhongwei Yang, et al. "Repair of critical diaphyseal defects of lower limbs by 3D printed porous Ti6Al4V scaffolds without additional bone grafting: a prospective clinical study." Journal of Materials Science: Materials in Medicine 33, no. 9 (2022). http://dx.doi.org/10.1007/s10856-022-06685-0.

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AbstractThe repair of critical diaphyseal defects of lower weight-bearing limbs is an intractable problem in clinical practice. From December 2017, we prospectively applied 3D printed porous Ti6Al4V scaffolds to reconstruct this kind of bone defect. All patients experienced a two-stage surgical process, including thorough debridement and scaffold implantation. With an average follow-up of 23.0 months, ten patients with 11 parts of bone defects were enrolled in this study. The case series included three females and seven males, their defect reasons included seven parts of osteomyelitis and four

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Singh, Srujan, Yuxiao Zhou, Ashley L. Farris, et al. "Geometric Mismatch Promotes Anatomic Repair in Periorbital Bony Defects in Skeletally Mature Yucatan Minipigs." Advanced Healthcare Materials, August 10, 2023. http://dx.doi.org/10.1002/adhm.202301944.

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AbstractPorous tissue‐engineered 3D‐printed scaffolds are a compelling alternative to autografts for the treatment of large periorbital bone defects. Matching the defect‐specific geometry has long been considered an optimal strategy to restore pre‐injury anatomy. However, studies in large animal models have revealed that biomaterial‐induced bone formation largely occurs around the scaffold periphery. Such ectopic bone formation in the periorbital region can affect vision and cause disfigurement. To enhance anatomic reconstruction, we introduced geometric mismatches in the scaffolds used to tre

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Huiwen, Wu, Liang Shuai, Xie Jia, et al. "3D-printed nanohydroxyapatite/methylacrylylated silk fibroin scaffold for repairing rat skull defects." Journal of Biological Engineering 18, no. 1 (2024). http://dx.doi.org/10.1186/s13036-024-00416-5.

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AbstractThe repair of bone defects remains a major challenge in the clinic, and treatment requires bone grafts or bone replacement materials. Existing biomaterials have many limitations and cannot meet the various needs of clinical applications. To treat bone defects, we constructed a nanohydroxyapatite (nHA)/methylacrylylated silk fibroin (MASF) composite biological scaffold using photocurable 3D printing technology. In this study, scanning electron microscopy (SEM) was used to detect the changes in the morphological structure of the composite scaffold with different contents of nanohydroxyap

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Rothweiler, R., S. Kuhn, T. Stark, et al. "Development of a new critical size defect model in the paranasal sinus and first approach for defect reconstruction—An in vivo maxillary bone defect study in sheep." Journal of Materials Science: Materials in Medicine 33, no. 11 (2022). http://dx.doi.org/10.1007/s10856-022-06698-9.

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AbstractFractures of the paranasal sinuses often require surgical intervention. Persisting bone defects lead to permanent visible deformities of the facial contours. Bone substitutes for reconstruction of defects with simultaneous induction of new bone formation are not commercially available for the paranasal sinus. New materials are urgently needed and have to be tested in their future area of application. For this purpose critical size defect models for the paranasal sinus have to be developed. A ≥2.4 cm large bilateral circular defect was created in the anterior wall of the maxillary sinus

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Suzuki, Shigeto, Venkata Suresh Venkataiah, Yoshio Yahata, et al. "Correction of large jaw bone defect in the mouse using immature osteoblast-like cells and a three dimensional polylactic acid scaffold." PNAS Nexus, August 8, 2022. http://dx.doi.org/10.1093/pnasnexus/pgac151.

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Abstract Bone tissue engineering has been developed using a combination of mesenchymal stem cells (MSCs) and calcium phosphate-based scaffolds. However, these complexes cannot regenerate large jawbone defects. To overcome this limitation of MSCs and ceramic scaffolds, a novel bone regeneration technology must be developed using cells possessing high bone forming ability and a scaffold that provides space for vertical bone augmentation. To approach this problem in our study, we developed alveolar bone-derived immature osteoblast-like cells (HAOBs), which have the bone regenerative capacity to c

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Jahromi, Hossein Kargar, Morteza Alizadeh, Arian Ehterami та ін. "EVALUATION OF THE EFFECT OF POLY (𝜀-CAPROLACTONE)/POLY (L-LACTIC) ACID/GELATIN NANOFIBER 3D SCAFFOLD CONTAINING RESVERATROL ON BONE REGENERATION". Biomedical Engineering: Applications, Basis and Communications 35, № 05 (2023). http://dx.doi.org/10.4015/s1016237223500278.

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Bone defects affect many people and impose expenses of costly treatment with possible complications. This study aims to investigate a novel Poly ([Formula: see text]-caprolactone)/Poly (L-lactic) acid/Gelatin nanofiber [PCL/PLA/GNF] scaffold containing 5% resveratrol (Resv) which was manufactured via thermally induced phase separation technique (TIPS), and its applicability for bone defect treatment. Gelatin nanofiber (GNF) was synthesized via the electrospinning method and mixed with PCL/PLA solution and then 5% resveratrol was added to fabricate a 3D scaffold via the TIPS technique. The prep

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Tao, Yuan, Meng Jia, Yang Shao-Qiang, et al. "A novel fluffy PLGA/HA composite scaffold for bone defect repair." Journal of Materials Science: Materials in Medicine 35, no. 1 (2024). http://dx.doi.org/10.1007/s10856-024-06782-2.

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AbstractTreatment of bone defects remains crucial challenge for successful bone healing, which arouses great interests in designing and fabricating ideal biomaterials. In this regard, the present study focuses on developing a novel fluffy scaffold of poly Lactide-co-glycolide (PLGA) composites with hydroxyapatite (HA) scaffold used in bone defect repair in rabbits. This fluffy PLGA/HA composite scaffold was fabricated by using multi-electro-spinning combined with biomineralization technology. In vitro analysis of human bone marrow mesenchymal stem cells (BMSCs) seeded onto fluffy PLGA/HA compo

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Ma, Lan, Yijun Yu, Hanxiao Liu, et al. "Berberine-releasing electrospun scaffold induces osteogenic differentiation of DPSCs and accelerates bone repair." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-020-79734-9.

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AbstractThe repair of skeletal defects in maxillofacial region remains an intractable problem, the rising technology of bone tissue engineering provides a new strategy to solve it. Scaffolds, a crucial element of tissue engineering, must have favorable biocompatibility as well as osteoinductivity. In this study, we prepared berberine/polycaprolactone/collagen (BBR/PCL/COL) scaffolds with different concentrations of berberine (BBR) (25, 50, 75 and 100 μg/mL) through electrospinning. The influence of dosage on scaffold morphology, cell behavior and in vivo bone defect repair were systematically

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