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Dissertations / Theses on the topic 'Scale-up industrial'

Author: Grafiati

Published: 7 September 2021

Last updated: 29 July 2025

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1

De, Ford D. "Scale-up of bioreactors : The concept of bioreactor number and its relation to the physiology of industrial micro-organisms at different scales." Thesis, Teesside University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.380694.

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2

Ali, Ali Salim. "Male circumcision managers' attitudes toward safe male circumcision program implementation and scale up in Botswana." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/79949.

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Thesis (MPhil)--Stellenbosch University, 2013.<br>ENGLISH ABSTRACT: Background: Safe Male circumcision (SMC) divides people for or against it, depending upon their attitudes. The Ministry of health (MOH) has built capacity in the country for rapid scale up of the program since 2009. However, despite the efforts, the number of men circumcised is lagging behind set targets. We do not know to what extent attitudes of the managers at national and district levels do influence this underperformance? The effectiveness of the managers at workplace at large will depend on their attitudes towards SMC. M

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3

Fernandes, Tânia Filipa Correia. "Scale up do processo de produção da bolacha Newkcal para a escala industrial - adaptação de uma linha de produção." Master's thesis, ISA, 2014. http://hdl.handle.net/10400.5/6775.

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Mestrado em Engenharia Alimentar - Processamento de Alimentos - Instituto Superior de Agronomia<br>This thesis portrays the scale up process of the semi-sweet biscuit production Newkcal from the pilot to industrial scale, highlighting occurred troubles, respective possible causes and the solutions adopted to solve them. These solutions resulted in modifications of the recipe and the biscuit manufacturing process, such as: reducing the total weight of Newkcal dough; opting for a three stage formulation of the dough; production of two different Newkcal formats with different production line spee

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4

NEVIANI, MATTEO. "Multiscale mathematical models for simulation and scale-up of green processes in the perspective of industrial sustainability." Doctoral thesis, Università degli studi di Genova, 2019. http://hdl.handle.net/11567/945483.

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The present work presents research studies aimed at developing tools useful to design engineering solutions moving in the direction of industrial sustainability. The investigations hereinafter discussed regard an extraction process of active compounds – polyphenols – from agro-food industry wastes (olive and grape pomaces) and a biorefinery exploiting waste frying oil, solid organic wastes and algal biomass to produce biofuels. In particular, for the former topic, a procedure aimed at the evaluation of the technological feasibility at pilot scale of said process is discussed. The propose

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5

De, Wet Tinus Andre. "Laboratory optimization of a protease extraction and purification process from bovine pancreas in preparation for industrial scale up." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/71790.

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Thesis (MSc)--Stellenbosch University, 2012.<br>ENGLISH ABSTRACT: This study describes: a) Characterization of traditional methodologies and testing methods used to purify and quantify trypsin and α-chymotrypsin b) Re-engineering / development of a new method for purifying trypsin and α-chymotrypsin that delivered higher product yields and improved control exercised over the process by investigating: i. Extraction methods ii. Centrifugation iii. Ultrafiltration iv. Chymotrypsinogen and trypsin crystallization v. Column chromatography vi. Investigation into different raw material source

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6

Shaik, Muneeb Ur Rahman. "Gas Dispersion Using an Up-Pumping Maxflo W Impeller." University of Dayton / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1398961959.

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7

Dai, Jianming. "Microwave-assisted extraction and synthesis studies and the scale-up study with the aid of FDTD simulation." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=100342.

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The research undertaken in this thesis includes microwave-assisted extraction (MAE), synthesis, and the investigation of the scale-up of the microwave-assisted processes with the numerical aid.<br>The main goal of this research is to study the various problems associated with the scale-up of the microwave-assisted extraction and synthesis processes. Laboratory studies were carried out to investigate the microwave-assisted extraction of known components from peppermint leaves and American ginseng. Various factors that influence the extraction processes were studied. Microwave-assisted extractio

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8

Brassell, James Philip. "Investigation of some scale-up conditions on the synthesis of faujasite zeolites from South African coal fly ash." Thesis, Cape Peninsula University of Technology, 2017. http://hdl.handle.net/20.500.11838/2483.

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Thesis (MTech (Chemical Engineering))--Cape Peninsula University of Technology, 2017.<br>Coal fly ash waste produced from the coal combustion process is becoming an ever increasing concern. It is produced in such abundance due to not only South Africa, but the whole of the world relying mainly on coal combustion for the main source of energy production. With the growing rate of the human population this energy production is ever increasing. The current methods of disposal of this fly ash is not sustainable, it is being dumped in ash dumps, and poses a risk to the surrounding environment and hu

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9

Pieck, Carlos Ariel. "Development of tools for the implementation of an industrial-scale supercritical fractionation process." Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM4317/document.

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Le fractionnement supercritique est un procédé prometteur avec un potentiel d’application encore peu exploité à grande échelle. Les travaux expérimentaux et la discussion théorique qui font l’objet de cette thèse ont pour objectif d’apporter des outils fiables permettant d’effectuer la mise en œuvre d’un procédé de fractionnement supercritique à l’échelle industrielle, en abordant le changement d’échelle et la modélisation du procédé. La première partie du travail porte sur le fractionnement de mélanges éthanol-eau en utilisant du dioxyde de carbone supercritique à 333 K et 10 MPa, sur des uni

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10

Lenzi, Lorenzo. "Upscale of a TCR® plant to industrial scale – characterisation and pre-testing of gas-scrubbing unit." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amslaurea.unibo.it/24926/.

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The Fraunhofer Institute for Environmental, Safety, and Energy Technology (Fraunhofer UMSICHT) at Sulzbach-Rosenberg, is developing a new method of intermediate pyrolysis, followed by reforming. The patented process, called Thermo-Catalytic-Reforming (TCR®), is the core technology in the To-Syn-Fuel project. The aim of the project is the production of advanced synthetic fuels from residual and waste materials (in particular sewage sludge), which are converted into the products bio-oil, as well as hydrogen, by means of the TCR®- plans. On the laboratory and pilot scale, the potential of this pr

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11

Lee, Darryl Liang Wee. "Development of a PP-MOCVD System and its Design and Operational Parameters for Uniform Industrial Coatings on 3D Objects." Thesis, University of Canterbury. Dept. of Mechanical Engineering, 2014. http://hdl.handle.net/10092/9644.

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Increase in demand for uniform ceramic coatings on larger industrial components have led to a need for a PP-MOCVD coating system scale up. The objective of this thesis is to develop a fully functional coating system operating in the PP-MOCVD regime that is able to deposit thin film ceramic coatings on commercial or industrial components with complex 3D geometries. This can be achieved by applying engineering and vacuum science theories, coupled with the established fundamentals of PP-MOCVD. A larger system was designed and assembled around the boundaries set by the dimensions and geometry of a

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12

Bölter, Marc [Verfasser], and Thomas M. [Akademischer Betreuer] Klapötke. "Synthesis and characterization of new environmentally benign secondary explosives based on azoles and further characterization of TKX‐50 and K2DNABT toward industrial scale‐up / Marc Bölter ; Betreuer: Thomas M. Klapötke." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2018. http://d-nb.info/122827049X/34.

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13

Ruiz, González Francisco. "Étude de l'élaboration de matériaux à très haute porosité par des procédés mettant en oeuvre des fluides supercritiques." Thesis, Université de Lorraine, 2015. http://www.theses.fr/2015LORR0332.

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Traitement et séchage de sol-gels est une pratique utilisée couramment dans l'industrie en raison du grand nombre d'applications existantes pour les produits en aval. Parmi eux, un produit spécifique capte une grande attention en raison de son élevé potentiel principalement pour l’application dans l'isolation thermique résidentielles, industrielles et même l'aérospatiale. Ce type de produit, appelé aérogel est un matériau dont la structure nanoporeuse marque une très faible densité et de conductivité thermique. La production d'aérogel peut être réalisée par diverses méthodes en fonction de la

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14

Kassim, Houssenaly Caroline. "Vinification continue avec levures immobilisées : analyse du système et conception du réacteur industriel." Thesis, Toulouse, INPT, 2012. http://www.theses.fr/2012INPT0013/document.

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Un nouveau procédé intensifié de vinification continue avec un mélange de levures S.cerevisiae et Sch.pombe immobilisées dans des billes d’alginate est proposé. A l’échelle laboratoire, l’étude de la teneur en billes et de la configuration du réacteur conduit à l’obtention d’un réacteur de type lit fixe permettant une production de vin en 35 heures. Des validations du procédé aux échelles pilote (170 L) puis industrielle (120 hL) montrent que, en cave, du vin de qualité semblable au témoin est produit en 2 à 3 jours. Une analyse du comportement du réacteur a identifié des raisons de pertes de

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Santos, João Filipe Gomes dos. "Desenvolvimento da produção de sidra a partir do concentrado de sumo de maçã e retentado." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22527.

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Mestrado em Biotecnologia - Biotecnologia Alimentar<br>A sidra é uma bebida obtida a partir da fermentação do sumo de maçã. Portugal não é um país com tradição no consumo de sidra, no entanto, há um claro padrão de crescimento, tanto em termos de volume, como em valor do consumo. Assim, a sidra apresenta-se com um forte potencial inexplorado, com um reduzido número de concorrentes, principalmente se utilizar como matéria-prima o concentrado de sumo de maçã, pelo que o lançamento de uma nova sidra poderá ser uma boa aposta no mercado das bebidas alcoólicas. O presente trabalho de estágio,

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16

Haupt, Anita, and André Lerch. "Forward Osmosis Application in Manufacturing Industries: A Short Review." Molecular Diversity Preservation International (MDPI), 2018. https://tud.qucosa.de/id/qucosa%3A32479.

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Forward osmosis (FO) is a membrane technology that uses the osmotic pressure difference to treat two fluids at a time giving the opportunity for an energy-efficient water and wastewater treatment. Various applications are possible; one of them is the application in industrial water management. In this review paper, the basic principle of FO is explained and the state-of-the-art regarding FO application in manufacturing industries is described. Examples of FO application were found for food and beverage industry, chemical industry, pharmaceutical industry, coal processing, micro algae cultivati

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17

Cristallini, Pietro Paolo. "Atom transfer radical polymerization di monomeri polari: studio delle condizioni utili per uno scale-up industriale." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amslaurea.unibo.it/13377/.

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In questo progetto è stata studiata la sintesi di copolimeri a blocchi poli(N-vinil caprolattame)-b-poli(vinil acetato) (PNVCL-b-PVAc) mediante Atom Transfer Radical Polymerization (ATRP). In visione di una futura produzione di questi materiali a livello industriale, è stato ritenuto interessante studiare questo processo utilizzando un solvente con alto valore di flash point, in particolare il polipropilen glicole Mn=1000g/mol (PPG-1000) (flash point 229°C). Inoltre, si è scelto di lavorare a temperature comprese tra 50 e 80°C, in modo da poter asportare il calore di reazione utilizzando sempl

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18

Santagiuliana, Michele <1992&gt. "Trasferimento e scale-up di processo produttivo per la sintesi di molecole di interesse farmaceutico." Master's Degree Thesis, Università Ca' Foscari Venezia, 2019. http://hdl.handle.net/10579/16034.

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La presente tesi è stata sviluppata nel corso dello stage svolto presso FIS – Fabbrica Italiana Sintetici, uno dei principali produttori italiani di principi attivi e intermedi per l’industria farmaceutica. L’attività, svolta presso i laboratori del reparto R&D, ha riguardato lo studio del processo produttivo per la sintesi di un principio attivo commissionata da una casa farmaceutica. Sono stati affrontati tutti gli aspetti coinvolti nelle fasi di trasferimento e scale-up di processo, quali: studi di stabilità, compatibilità dei materiali, studi di solubilità, valutazione dei reflui, valutazi

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19

Reichert, Ute. "Prozessdesign, Prozessoptimierung und scale up am Beispiel des industriell relevanten Enzyms Formiatdehydrogenase aus E. coli." [S.l. : s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=96841365X.

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20

CAPITANI, CHIARA. "Synthesis of semiconductor colloidal nanocrystals with large Stokes-shift for luminescent solar concentrators." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2022. http://hdl.handle.net/10281/366195.

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I concentratori solari luminescenti (LSCs) sono delle guide d’onda composti da una matrice polimerica drogata o ricoperta con fluorofori. La luce solare diretta e/o diffusa che penetra nella matrice è assorbita dai fluorofori e poi riemessa dagli stessi con energia minore. La luce emessa, grazie alla riflessione totale interna, propaga fino a raggiungere i bordi della guida d’onda dove è convertita in elettricità da celle fotovoltaiche poste sul perimetro della matrice. L’efficienza del dispositivo è ridotta da numerosi processi di perdita, sia dovuti alla riflessione della matrice e al cono d

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21

Taraborelli, Simone. "Studio del reforming combinato del biogas su nanoparticelle bimetalliche supportate." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amslaurea.unibo.it/21674/.

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The study of the combined reforming (CR) process to produce synthesis gas (CO + H2) feeding Clean Biogas (CB, biogas in which the main pollutants have been removed) has been performed on Ni-based bimetallic catalysts promoted by small amounts of Rh or Cu, prepared by incipient wetness impregnation or coprecipitation of different precursors on mixed oxides Mg/Al/O obtained by calcination of hydrotalcite-type (Ht) coprecipitates. It has been observed as the formation of bimetallic particles promoted the catalytic activity and limited the deactivation phenomena, allowing to operate at lower tem

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22

Jourdier, Etienne. "Modélisation et optimisation de la production de cellulases par Trichoderma reesei pour les bioraffineries lignocellulosiques." Thesis, Clermont-Ferrand 2, 2012. http://www.theses.fr/2012CLF22264.

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Dans le contexte énergétique et climatique mondial, le coût élevé des enzymes Cellulolytiques (cellulases) freine le développement des bioraffineries lignocellulosiques, pour produire des biocarburants et composés chimiques à partir d'une matière première végétale renouvelable. L'objectif de ce travail est de caractériser et de modéliser le métabolisme du micro-organisme Trichoderma reesei, afin d'optimiser le protocole industriel de production de cellulases. Cette étude a été réalisée sur des milieux modèles représentatifs de ceux attendus à l'échelle industrielle. Tout d'abord, la stoechiomé

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23

Pigou, Maxime. "Modélisation du comportement cinétique, des phénomènes de mélange et de transfert locaux, et des effets d'hétérogénéité de population dans les fermenteurs industriels." Thesis, Toulouse, INSA, 2018. http://www.theses.fr/2018ISAT0038.

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La simulation devient un outil incontournable pour concevoir ou optimiser les procédés en biotechnologies. Elle est particulièrement pertinente pour permettre le changement d'échelle de l'échelle laboratoire à la mise en œuvre de cultures biologiques industrielles. Cette thèse se concentre sur le développement d'une structure de modèle pour les fermenteurs, qui ne néglige ni les problématiques de mélange, ni la complexité biologique, tout en permettant des simulations rapides. Pour intégrer l'ensemble des phénomènes couplés et dynamiques interagissant dans les bioréacteurs, l'approche proposée

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24

Castagnini, Simone. "Dal piccolo al grande: scale up e industrializzazione del processo di produzione di un nuovo piretroide sintetico." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2022.

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Il presente lavoro di tesi ha avuto l’obiettivo di realizzare la fase di Conceptual Design e di avviare la fase di Basic Design preliminari allo sviluppo di un processo industriale per la produzione di un nuovo piretroide dotato di spiccato potere insetticida. Il lavoro svolto si inquadra innanzitutto nell’ambito del Conceptual Design, ovvero nella definizione delle caratteristiche del processo, delle specifiche di prodotto, della sequenza delle operazioni fondamentali, dei dati chimico- fisici delle sostanze coinvolte e, infine, degli aspetti termici e di sicurezza da tenere in considerazione

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25

Chiossi, Francesco. "Sviluppo di un processo in continuo per la sintesi di un intermedio farmaceutico." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2022. http://amslaurea.unibo.it/25476/.

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In this work process for the coupling reaction between a secondary chiral alcohol and a heterocyclic amine is studied. The chiral configuration must be inverted. The mesylate derivative of the alcohol is known to be unstable, so a continuous process with no isolation is developed for alcohol activation and amine coupling. This approach led to poor results in terms of yield and chiral purity. As an alternative approach, the Mitsunobu reaction is used. The application of flow chemistry to this reaction is promising since it uses highly energetic compounds and has a fast kinetic. Despite these pr

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26

Violas, Antoine. "Disperser l'eau dans une matière grasse solide : des mécanismes élémentaires qu procédé industriel." Electronic Thesis or Diss., Université de Toulouse (2023-....), 2024. http://www.theses.fr/2024TLSEP077.

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Le développement de produits ayant un taux de matière grasse réduit est, tant d’un point de vue économique que nutritionnel, un enjeu majeur. La réduction de ce taux peut être réalisée à travers la dispersion d’une phase aqueuse dans la matière grasse initiale. Cette dispersion est couramment réalisée industriellement par mélange en voie liquide, mais le recours à des tensioactifs est nécessaire au maintien d’une émulsion stable. Une autre alternative peut être trouvée dans l’incorporation d’eau à l’intérieur de la matière grasse dans son état partiellement cristallisé. Cette méthode tire avan

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27

Crimaldi, Antonio. "Nuovi processi catalitici per la produzione di syngas." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/19204/.

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The study of the combined Steam/Dry Reforming (S/DR) process for the production of syngas (CO + H2) from clean biogas was carried out using Ni/Ir bimetallic catalysts on Mg and Al mixed-oxides, obtained by calcination of hydrotalcite-type precursors (Ht) prepared by co-precipitation. The presence of small amounts of Ir promoted the catalytic activity and limited the deactivation phenomena through the formation of a bimetallic alloy, which does the catalyst very active even at lowest temperature and in lack of steam. By integrating a High Temperature–WGS unit (HTS) after the S/DR reactor it was

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Mainhas, Daniela Patricia Alves. "Start-Up and optimization of pilot and industrial scale membrane systems for pre-concentration of microalgae." Master's thesis, 2021. http://hdl.handle.net/10362/112049.

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Microalgae is an industry that has been evolving a lot throughout the later years and has quite some advantages especially to the environment, from the consumption of carbon dioxide to the replacement of fossil fuel with biofuel. But, in order to produce microalgae, they need a medium to grow that needs, later, to be separated in order to obtain only the microalgae. There are several ways to separate the algae from the medium, among which are centrifugation, flocculation and sedimentation, but they have their disadvantages as they are time-consuming, uneconomic and bad for the environment. On

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Mainhas, Daniela Patricia Alves. "Start-Up and Optimization of Pilot and Industrial Scale Membrane Systems for Pre-Concentration of Microalgae." Master's thesis, 2020. http://hdl.handle.net/10362/111053.

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Microalgae is an industry that has been evolving a lot throughout the later years and has quite some advantages especially to the environment, from the consumption of carbon dioxide to the replacement of fossil fuel with biofuel. But, in order to produce microalgae, they need a medium to grow that needs, later, to be separated in order to obtain only the microalgae. There are several ways to separate the algae from the medium, among which are centrifugation, flocculation and sedimentation, but they have their disadvantages as they are time-consuming, uneconomic and bad for the environment. On

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D'Ercole, Annunziata. "Development and scale-up of synthetic strategies for exotic macrocyclisation to increase druggability of peptides as active pharmaceutical ingredients of industrial interest." Doctoral thesis, 2022. http://hdl.handle.net/2158/1264636.

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In the framework of the PhD project of industrial interest, I have been involved in the development and optimization of synthetic procedures to obtain peptides of pharmaceutical interest, both on the laboratory scale and for the industrial production, in the context of the University-Industry Joint Laboratory PeptFarm of the University of Florence. This research develops through two parallel lines. The former is related to the development of a multigram, scalable cGMP-compliant MW-SP synthetic approach for the manufacture of the cyclic peptide Active Pharmaceutical Ingredient Eptifibat

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Pereira, Ana Rita Pontes. "Optimizing the scale up biochemical platform biorefinery for lactic acid production from lignocellulosic biomass." Doctoral thesis, 2021. http://hdl.handle.net/10316/96395.

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Tese no âmbito do doutoramento em Biociências, especialização em Biotecnologia orientada pelo Professor Doutor José António Couto Teixeira, pelo Professor Doutor António Manuel Veríssimo Pires, e pelo Doutor João Miguel dos Santos Almeida Nunes e apresentada ao Departamento de Ciências da Vida da Faculdade de Ciências e Tecnologia da Universidade de Coimbra.<br>Lignocellulosic biomass, such as forest and agriculture residues or dedicated energy crops, is a promising renewable feedstock for the production of advanced biofuels and chemical building blocks. Lactic acid (LA) has been identified as

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Borges, Carolina do Nascimento. "Otimização e scale-up de soluções para valorização de desperdícios industriais." Master's thesis, 2021. https://hdl.handle.net/10216/133347.

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Borges, Carolina do Nascimento. "Otimização e scale-up de soluções para valorização de desperdícios industriais." Dissertação, 2021. https://hdl.handle.net/10216/133347.

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Reichert, Ute [Verfasser]. "Prozessdesign, Prozessoptimierung und scale up am Beispiel des industriell relevanten Enzyms Formiatdehydrogenase aus E. coli / vorgelegt von Ute Reichert." 2002. http://d-nb.info/96841365X/34.

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Carvalho, Ana Catarina Teixeira. "Otimização do método de produção de Oxitetraciclina Cálcica e Limeciclina: Downscale dos processos industriais e desenvolvimento de novo método analítico." Master's thesis, 2020. http://hdl.handle.net/10362/112783.

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A oxitetraciclina cálcica e a Limeciclina são ingredientes farmacêuticos ativos (API) produzidos na Cipan, possuindo processos de fabrico muito semelhantes entre si, sendo a precipitação o passo crítico nas respetivas sínteses. Um dos principais objetivos deste projeto visa à otimização da síntese de oxitetraciclina cálcica de forma a obter valores percentuais de cálcio estáveis, dentro dos limites de especificação. Foram estudadas as seguintes variáveis: tempo de adição de solução precipitante durante a precipitação, eliminação de uma das etapas do processo e redução da concentração de solu

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