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1

Sutherland, I. A., L. Brown, A. S. Graham, et al. "Industrial Scale-Up of Countercurrent Chromatography: Predictive Scale-Up." Journal of Chromatographic Science 39, no. 1 (2001): 21–28. http://dx.doi.org/10.1093/chromsci/39.1.21.

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2

Jackson, A. T. "Some problems of industrial scale-up." Journal of Biological Education 19, no. 1 (1985): 48–52. http://dx.doi.org/10.1080/00219266.1985.9654686.

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3

Geipel, Christian, Karl Hauptmeier, Kai Herbrig, et al. "Stack Development and Industrial Scale-Up." ECS Transactions 91, no. 1 (2019): 123–32. http://dx.doi.org/10.1149/09101.0123ecst.

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4

Sutherland, I. A., A. J. Booth, L. Brown, et al. "INDUSTRIAL SCALE-UP OF COUNTERCURRENT CHROMATOGRAPHY." Journal of Liquid Chromatography & Related Technologies 24, no. 11-12 (2001): 1533–53. http://dx.doi.org/10.1081/jlc-100104362.

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5

Meulenberg, Rogier. "Scale up of industrial enzyme production." New Biotechnology 29 (September 2012): S75. http://dx.doi.org/10.1016/j.nbt.2012.08.209.

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6

Rodriguez, F., M. Ramirez, R. Ruiz, and F. Concha. "Scale-up procedure for industrial cage mills." International Journal of Mineral Processing 97, no. 1-4 (2010): 39–43. http://dx.doi.org/10.1016/j.minpro.2010.07.010.

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7

Sadighi, Sepehr, Seyed Reza Seif Mohaddecy, and Mehdi Rashidzadeh. "Modeling, Evaluating and Scaling up a Commercial Multilayer Claus Converter Based on Bench Scale Experiments." Bulletin of Chemical Reaction Engineering & Catalysis 15, no. 2 (2020): 465–75. http://dx.doi.org/10.9767/bcrec.15.2.7521.465-475.

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Industrial scale reactors work adiabatically and measuring their performance in an isothermal bench scale reactor is faced with uncertainties. In this research, based on kinetic models previously developed for alumina and titania commercial Claus catalysts, a multilayer bench scale model is constructed, and it is applied to simulate the behavior of an industrial scale Claus converter. It is shown that performing the bench scale isothermal experiments at the temperature of 307 ºC can reliably exhibit the activity of catalytic layers of an industrial Claus converter operating at the weighted ave
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8

Mascarenhas, João, M. Alexandra Barreiros, and Maria João Brites. "Scale up of microwave annealed FA0.83Cs0.17PbI1.8Br1.2 perovskite towards an industrial scale." Materials Letters: X 5 (March 2020): 100029. http://dx.doi.org/10.1016/j.mlblux.2019.100029.

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9

Hoeks, Frans W. J. M. M., Lotte A. Boon, Fabian Studer, et al. "Scale-up of stirring as foam disruption (SAFD) to industrial scale." Journal of Industrial Microbiology & Biotechnology 30, no. 2 (2003): 118–28. http://dx.doi.org/10.1007/s10295-003-0023-7.

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10

Schmidt, F. R. "Optimization and scale up of industrial fermentation processes." Applied Microbiology and Biotechnology 68, no. 4 (2005): 425–35. http://dx.doi.org/10.1007/s00253-005-0003-0.

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11

Pruesse, Ulf, Ulrich Jahnz, Peter Wittlich, and Klaus-Dieter Vorlop. "Scale-up of the jetcutter technology." Chemical Industry 57, no. 12 (2003): 636–40. http://dx.doi.org/10.2298/hemind0312636p.

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The JetCutter is a new, simple and efficient technology for the high throughput encapsulation of various materials inside spherical beads. Monodisperse beads in the particle size range from approximately 0.2 mm up to several millimeters can be prepared at high throughput rates with the JetCutter. The generation of beads is not limited by the fluid viscosity. Thus, also highly viscous fluids even with high loadings of solids, can be processed, which leads to an improved stability of the resulting beads. The JetCutter technology is available in different scales and corresponding throughputs rang
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12

Toepfl, Stefan. "Pulsed Electric Field food treatment - scale up from lab to industrial scale." Procedia Food Science 1 (2011): 776–79. http://dx.doi.org/10.1016/j.profoo.2011.09.117.

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13

Tuchlenski, A., A. Beckmann, D. Reusch, R. Düssel, U. Weidlich, and R. Janowsky. "Reactive distillation — industrial applications, process design & scale-up." Chemical Engineering Science 56, no. 2 (2001): 387–94. http://dx.doi.org/10.1016/s0009-2509(00)00240-2.

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14

MURAKAMI, SEI, RYUSEI NAKANO, and TATSUHIKO MATSUOKA. "Scale-Up of Fermenter. Survey of Industrial Fermenter Specifications." KAGAKU KOGAKU RONBUNSHU 26, no. 4 (2000): 557–62. http://dx.doi.org/10.1252/kakoronbunshu.26.557.

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15

MURAKAMI, Sei, Susumu HARADA, and Shuichi YAMAMOTO. "Scale-Up of Fermenter." Japan Journal of Food Engineering 2, no. 2 (2001): 53–61. http://dx.doi.org/10.11301/jsfe2000.2.53.

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16

Medici, Franco. "Recovery of Waste Materials: Technological Research and Industrial Scale-Up." Materials 15, no. 2 (2022): 685. http://dx.doi.org/10.3390/ma15020685.

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17

Muhamadali, Howbeer, Yun Xu, David I. Ellis, et al. "Metabolic Profiling of Geobacter sulfurreducens during Industrial Bioprocess Scale-Up." Applied and Environmental Microbiology 81, no. 10 (2015): 3288–98. http://dx.doi.org/10.1128/aem.00294-15.

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ABSTRACTDuring the industrial scale-up of bioprocesses it is important to establish that the biological system has not changed significantly when moving from small laboratory-scale shake flasks or culturing bottles to an industrially relevant production level. Therefore, during upscaling of biomass production for a range of metal transformations, including the production of biogenic magnetite nanoparticles byGeobacter sulfurreducens, from 100-ml bench-scale to 5-liter fermentors, we applied Fourier transform infrared (FTIR) spectroscopy as a metabolic fingerprinting approach followed by the an
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18

Sutherland, Ian, David Hawes, Svetlana Ignatova, Lee Janaway, and Philip Wood. "Review of Progress Toward the Industrial Scale‐Up of CCC." Journal of Liquid Chromatography & Related Technologies 28, no. 12-13 (2005): 1877–91. http://dx.doi.org/10.1081/jlc-200063521.

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19

Schmidt, F. R. "Erratum to: Optimization and scale up of industrial fermentation processes." Applied Microbiology and Biotechnology 68, no. 6 (2005): 818–20. http://dx.doi.org/10.1007/s00253-005-0100-0.

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20

Zlokarnik, Marko. "DIMENSIONAL ANALYSIS AND SCALE-UP IN THEORY AND INDUSTRIAL APPLICATION*." Journal of Liposome Research 11, no. 4 (2001): 269–307. http://dx.doi.org/10.1081/lpr-100108610.

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21

Ettler, Petr. "Scale-up and scale-down techniques for fermentations of polyene antibiotics." Collection of Czechoslovak Chemical Communications 55, no. 7 (1990): 1730–40. http://dx.doi.org/10.1135/cccc19901730.

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Our philosophy of successful biotechnology transfer to industrial scale covers the comparison of complex sets of microbiological, analytical and bioengineering data from cultivations in various scales and different geometries of mixing with laboratory findings. In particular, the availability of nutrients to producing microorganism should be understood, therefore for quick scaling-up procedure of polyene antibiotics produced by Streptomyces noursei we recommend to use physiological marker as total dehydrogenase activity determination. The utility of scale-down tests for identification of proce
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22

Eiden, Ulrich, Rudolf Kaiser, Gunter Schuch, and Dieter Wolf. "Scale-up von Destillationskolonnen." Chemie Ingenieur Technik 67, no. 3 (1995): 269–79. http://dx.doi.org/10.1002/cite.330670303.

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23

Zlokarnik, M. "Scale-up und Miniplants." Chemie Ingenieur Technik 75, no. 4 (2003): 370–75. http://dx.doi.org/10.1002/cite.200390074.

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24

Cleary, Paul W., Matt D. Sinnott, and Rob D. Morrison. "Scale-Up Investigation of a Pilot and Industrial Scale Semi-Autogenous Mill Using a Particle Scale Model." Minerals 13, no. 12 (2023): 1490. http://dx.doi.org/10.3390/min13121490.

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A particle scale model based on a full two-way coupling of the Discrete Element Method (DEM) and Smoothed Particle Hydrodynamics (SPHs) methods is applied to SAG mills. Motion and collisions of resolved coarser particles within an SAG mill are performed by the DEM component. Fine particles in the feed combine with the water to form a slurry, which is represented by the SPH component of the model. Slurry rheology is controlled by solid loading and fine particle size distribution for each volume of slurry. Transport, dispersion, and grinding of the slurry phase particle size distribution are pre
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25

Sabet, Hossein, Shabnam Sadri Moghaddam, and Farzad Piadeh. "Rapid sustainability assessment of sludge management technologies for industrial scale-up." Sustainable Production and Consumption 53 (January 2025): 163–76. https://doi.org/10.1016/j.spc.2024.12.007.

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26

Bell, Timothy A. "Challenges in the scale-up of particulate processes—an industrial perspective." Powder Technology 150, no. 2 (2005): 60–71. http://dx.doi.org/10.1016/j.powtec.2004.11.023.

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27

Sutherland, Ian A. "Recent progress on the industrial scale-up of counter-current chromatography." Journal of Chromatography A 1151, no. 1-2 (2007): 6–13. http://dx.doi.org/10.1016/j.chroma.2007.01.143.

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28

Wang, Guan, Cees Haringa, Wenjun Tang, et al. "Coupled metabolic‐hydrodynamic modeling enabling rational scale‐up of industrial bioprocesses." Biotechnology and Bioengineering 117, no. 3 (2019): 844–67. http://dx.doi.org/10.1002/bit.27243.

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29

Zhao, Xiangyin. "Toward industrial scale-up of polypeptide synthesis: analysis of monomer suitability." Journal of Physics: Conference Series 2608, no. 1 (2023): 012037. http://dx.doi.org/10.1088/1742-6596/2608/1/012037.

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Abstract Polypeptide is a class of biopolymers that mimic the structure and properties of natural proteins, which makes it fitting for biological applications. The biodegradability and biocompatibility from the peptide backbones combined with the tunability from synthetic chemistry allow for long-chain polypeptides to function for drug delivery, tissue grafting, and gene therapy. Currently, long-chain polypeptides (≥100 amino acids) are not synthesized on a commercial scale (>100 kg.) Based on the potential applications, the optimization of polypeptide production should be discussed at the
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30

Zlokarnik, M. "Scale-up from Mini Plants." Chemical Engineering & Technology 27, no. 1 (2004): 23–27. http://dx.doi.org/10.1002/ceat.200403158.

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31

Haindl, Susanne, Julia Stark, Jannik Dippel, Sebastian Handt, and Annette Reiche. "Scale‐up of Microfiltration Processes." Chemie Ingenieur Technik 92, no. 6 (2020): 746–58. http://dx.doi.org/10.1002/cite.201900025.

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32

Neubert, Benedikt, Christoph Dohm, Johannes Wortberg, and Marius Janßen. "A process-oriented scale-up/scale-down strategy for industrial blown film processes: Theory and experiments." Journal of Plastic Film & Sheeting 34, no. 3 (2017): 324–49. http://dx.doi.org/10.1177/8756087917741926.

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To gain a competitive edge in developing innovative products, new multi-layer film manufacturers need to know whether laboratory-scale blown film line results reliably translate to large-scale production. This, however, is not always the case: Transferring process conditions and getting equal final film properties are not ensured. To address this problem, this paper presents a scale-independent scale-up/scale-down strategy to produce films with consistently similar properties regardless of a plant’s size and design. A second aim is to prove this strategy is applicable by comparing the referenc
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33

Martin, A. J., S. Mitchell, K. Kunze, K. C. Weston, and J. Pérez-Ramírez. "Visualising compositional heterogeneity during the scale up of multicomponent zeolite bodies." Materials Horizons 4, no. 5 (2017): 857–61. http://dx.doi.org/10.1039/c7mh00088j.

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34

Chew, Chun Ming, M. K. Aroua, and M. A. Hussain. "Key issues of ultrafiltration membrane water treatment plant scale-up from laboratory and pilot plant results." Water Supply 16, no. 2 (2015): 438–44. http://dx.doi.org/10.2166/ws.2015.154.

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Industrial-scale ultrafiltration (UF) membrane systems have gained wide acceptance for producing safe drinking water. Laboratory and pilot plant studies are often carried out prior to the design of full-scale water treatment plants. Emphases are laid on how accurately these laboratory and pilot plant studies represent actual industrial-scale systems and the limitations. A case study which encompasses laboratory experiments, pilot plant and industrial-scale UF systems has been carried out in Malaysia using the same type of modified polyethersulfone hollow fiber UF membrane and surface raw water
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35

van Heugten, Anton J. P., and Herman Vromans. "Scale up of Semisolid Dosage Forms Manufacturing Based on Process Understanding: from Lab to Industrial Scale." AAPS PharmSciTech 19, no. 5 (2018): 2330–34. http://dx.doi.org/10.1208/s12249-018-1063-7.

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36

Fu, Chaopeng, and Patrick S. Grant. "Toward Low-Cost Grid Scale Energy Storage: Supercapacitors Based on Up-Cycled Industrial Mill Scale Waste." ACS Sustainable Chemistry & Engineering 3, no. 11 (2015): 2831–38. http://dx.doi.org/10.1021/acssuschemeng.5b00757.

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37

Operti, Maria Camilla, Alexander Bernhardt, Silko Grimm, Andrea Engel, Carl Gustav Figdor, and Oya Tagit. "PLGA-based nanomedicines manufacturing: Technologies overview and challenges in industrial scale-up." International Journal of Pharmaceutics 605 (August 2021): 120807. http://dx.doi.org/10.1016/j.ijpharm.2021.120807.

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38

Fiore, S., B. Ruffino, G. Campo, C. Roati, and M. C. Zanetti. "Scale-up evaluation of the anaerobic digestion of food-processing industrial wastes." Renewable Energy 96 (October 2016): 949–59. http://dx.doi.org/10.1016/j.renene.2016.05.049.

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39

Lee, Darryl, Susan Krumdieck, and Sam Davies Talwar. "Scale-up design for industrial development of a PP-MOCVD coating system." Surface and Coatings Technology 230 (September 2013): 39–45. http://dx.doi.org/10.1016/j.surfcoat.2013.06.064.

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40

Yan, Pu-Cha, Guo-Liang Zhu, Jian-Hua Xie, et al. "Industrial Scale-Up of Enantioselective Hydrogenation for the Asymmetric Synthesis of Rivastigmine." Organic Process Research & Development 17, no. 2 (2013): 307–12. http://dx.doi.org/10.1021/op3003147.

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41

Kodama, Masato, Shouzou Ishizawa, Atsushi Koiwa, Takeo Kanaki, Ken Shibata, and Hirotoshi Motomura. "Scale-up of liquid chromatography for industrial production of parenteral antibiotic E1077." Journal of Chromatography A 707, no. 2 (1995): 117–29. http://dx.doi.org/10.1016/0021-9673(95)00140-i.

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42

Ronda, A., M. A. Martín-Lara, O. Osegueda, V. Castillo, and G. Blázquez. "Scale-up of a packed bed column for wastewater treatment." Water Science and Technology 77, no. 5 (2018): 1386–96. http://dx.doi.org/10.2166/wst.2018.020.

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Abstract After checking the success of the biosorption process to remove heavy metals from wastewater using olive tree pruning as a cheap biosorbent in the laboratory scale, the scale-up is necessary to progress towards industrial applications chance. The aim of this work was the study of the effect of scale-up in the process of biosorption of Pb(II) with olive tree pruning in a packed bed column. Experiments were performed using two different scale-up criteria and results obtained in both scales were compared. Similar parameters were obtained for each pair of equivalent tests, with a slightly
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43

Zahradník, Jindřich, and Milan Rylek. "Design and scale-up of Venturi-tube gas distributors for bubble column reactors." Collection of Czechoslovak Chemical Communications 56, no. 3 (1991): 619–35. http://dx.doi.org/10.1135/cccc19910619.

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General principles of ejector distributors performance are surveyed and demonstrated for two particular cases of Venturi tubes commonly employed for gas dispersion in tower reactors with forced liquid circulation. Design recommendations for the two types of Venturi-tube gas distributors are presented and a general method is outlined for ejector distributors scale-up, based on the decisive effect of energy dissipation rate on the distributors performance. As an illustration, the specific case of Venturi-tube gas distributor design for an industrial reactor for catalytic hydrogenation of rape-se
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44

Eiden, U., R. Kaiser, and G. Schuch. "159. Zum Scale-up von Destillationskolonnen." Chemie Ingenieur Technik 66, no. 9 (1994): 1256. http://dx.doi.org/10.1002/cite.3306609160.

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45

Mendorf, Matthias, and David W Agar. "Scale-up of Capillary Extraction Equipment." Chemie Ingenieur Technik 83, no. 7 (2011): 1120–24. http://dx.doi.org/10.1002/cite.201100026.

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46

Çakal, Gaye. "Production of fine zinc borate in industrial scale." Chemical Industry and Chemical Engineering Quarterly 18, no. 4-1 (2012): 547–53. http://dx.doi.org/10.2298/ciceq120224031c.

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In this study, zinc borate production in an industrial scale batch reactor was carried out at the optimum process conditions determined in the previous studies performed at the laboratory and pilot scale reactors. The production was done via the heterogeneous reaction of boric acid and zinc oxide. The samples were characterized by chemical analysis, XRD, TGA, SEM and particle size distribution. The final product which was obtained in the industrial scale reactor was 2ZnO.3B2O3.3H2O. The kinetic data for the zinc borate production reaction fit to a modified logistic model where the lag time was
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47

Ganeshan, Seedhabadee, and Mehmet Çağlar Tülbek. "Fermentative Butanol Production—Perspectives and Scale-Up Challenges." Encyclopedia 5, no. 2 (2025): 50. https://doi.org/10.3390/encyclopedia5020050.

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Sustainable solutions to the use of petrochemical products have been increasingly sought after in recent years. While alternatives such as biofuels have been extensively explored and commercialized, major challenges remain in using heterogeneous feedstocks and scaling-up processes. Among biofuels, higher alcohols have recently gained renewed interest, especially in the context of upcycling agri-food residues and other industrial organic wastes. One of the higher alcohols produced via fermentation is butanol, which was developed over a century ago. However, the commercial production of butanol
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48

Kamravamanesh, Donya, Daniel Kiesenhofer, Silvia Fluch, Maximilian Lackner, and Christoph Herwig. "Scale-up challenges and requirement of technology-transfer for cyanobacterial poly (3-hydroxybutyrate) production in industrial scale." International Journal of Biobased Plastics 1, no. 1 (2019): 60–71. http://dx.doi.org/10.1080/24759651.2019.1688604.

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49

Piccinno, Fabiano, Roland Hischier, Stefan Seeger, and Claudia Som. "From laboratory to industrial scale: a scale-up framework for chemical processes in life cycle assessment studies." Journal of Cleaner Production 135 (November 2016): 1085–97. http://dx.doi.org/10.1016/j.jclepro.2016.06.164.

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50

Radoiu, Marilena, Harmandeep Kaur, Anna Bakowska-Barczak, and Steven Splinter. "Microwave-Assisted Industrial Scale Cannabis Extraction." Technologies 8, no. 3 (2020): 45. http://dx.doi.org/10.3390/technologies8030045.

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Cannabis is a flowering plant that has long been used for medicinal, therapeutic, and recreational purposes. Cannabis contains more than 500 different compounds, including a unique class of terpeno-phenolic compounds known as cannabinoids. Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are the most extensively studied cannabinoids. They have been associated with the therapeutic and medicinal properties of the cannabis plant and also with its popularity as a recreational drug. In this paper, an industrial method for cannabis extraction using 915 MHz microwaves coupled with continuous flow
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