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Journal articles on the topic 'Scary Thugs'

Author: Grafiati

Published: 27 July 2024

Last updated: 31 July 2025

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1

Dvoriankova, E., M. Karapetyan, G. Shevchenko, and I. Korsunskaya. "Modern view on the problem of keloid scars." Vrach 34, no. 9 (2023): 18–22. http://dx.doi.org/10.29296/25877305-2023-10-03.

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Serious skin injuries can lead to the formation of scars, in particular hypertrophic and keloid scars. The prevalence of keloids and hypertrophic scars varies among different populations. Scar formation is a natural process during wound healing, but when keloid scars form, regeneration is impaired. It is generally accepted that a keloid scar is formed as a result of increased synthesis of collagen and extracellular matrix against the background of reduced degradation of these products. Clinically, keloid and hypertrophic scars have a number of differences. Thus, the formation of a keloid scar

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2

McGoldrick, Rory Boyd, Evgenia Theodorakopoulou, Ernest Anthony Azzopardi, and Maxwell Murison. "Lasers and ancillary treatments for scar management Part 2: Keloid, hypertrophic, pigmented and acne scars." Scars, Burns & Healing 3 (January 1, 2017): 205951311668980. http://dx.doi.org/10.1177/2059513116689805.

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The formation of a wide range of excessive scars following various skin injuries is a natural consequence of healing. Scars resulting from surgery or trauma affect approximately 100 million people per annum in the developed world and can have profound physical, aesthetic, psychological and social consequences. Thus, scar treatment is a priority for patient and physician alike. Laser treatment plays an important role in scar management with additional support from ancillary modalities. Subsequent to part 1: Burns scars, part 2 focuses on our strategies and literature review of treatment of kelo

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McGoldrick, Rory B., Adam Sawyer, Christopher R. Davis, Evgenia Theodorakopoulou, and Maxwell Murison. "Lasers and ancillary treatments for scar management: personal experience over two decades and contextual review of the literature. Part I: Burn scars." Scars, Burns & Healing 2 (January 1, 2016): 205951311664209. http://dx.doi.org/10.1177/2059513116642090.

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[Formula: see text] [Formula: see text] [Formula: see text] The formation of a wide range of excessive scars following various skin injuries is a natural consequence of healing. Scars resulting from surgery or trauma affect approximately 100 million people per annum in the developed world and can have profound physical, aesthetic, psychological and social consequences. Thus, scar treatment is a priority for the plastic surgeon. We aim to explore new approaches to the management of such scarring. The senior authors current use of laser technology, chemotherapeutic agents, pharmacotherapy and cr

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Tsai, Jenn, Samy Bendjemil, Colin Dowling, and Stathis Poulakidas. "721 Treatment of Hypertrophic Burn and Wound Scars Using a Novel Cold Laser System." Journal of Burn Care & Research 41, Supplement_1 (2020): S191—S192. http://dx.doi.org/10.1093/jbcr/iraa024.305.

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Abstract Introduction Hypertrophic scars are seen in 70% of individuals after a burn. Survival from acute burns have psychosocial and functional challenges. Hypertrophic scars contain disorganized whorls of collagen, an increase in occluded blood vessels resulting in raised discoloration, inflamed dermis/epidermis and painful sequelae. Management of such scars have been limited to invasive and non-invasive management. One innovative technology is a non-invasive high-intensity laser operating at 1275 nm and 74 Watts, optimizing increased depth of penetration into the tissue utilizing photomecha

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Lee, Key Day, Jaeyoung Cho, Sang Yoon Kang, and Jin Sik Burm. "Early Compression Therapy for Deep Skin Defects: A New Treatment Option to Prevent Hypertrophic Scars or Contractures." Journal of Wound Management and Research 18, no. 3 (2022): 178–85. http://dx.doi.org/10.22467/jwmr.2022.02201.

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Background: Conservative treatment of deep dermal or full-thickness skin defects often results in hypertrophic scars or contractures; thus, compressive therapy has been used after wound closure to prevent or treat scar deformities. However, wound contraction begins in the early proliferative phase and peaks after 2 weeks. We therefore attempted early compression therapy as a means of conservative treatment of deep-skin defects and evaluated its clinical outcomes. Methods: In 21 cases of deep skin defects (19 patients), early compressive therapy was started the second week after injury. Saline-

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Casagranda, Aneline, Mariano Suppa, Florence Dehavay, and Véronique del Marmol. "Overlapping DRESS and Stevens-Johnson Syndrome: Case Report and Review of the Literature." Case Reports in Dermatology 9, no. 2 (2017): 1–7. http://dx.doi.org/10.1159/000475802.

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Drug-induced severe cutaneous adverse reactions (SCARs) include acute generalized exanthematous pustulosis, drug reaction with eosinophilia and systemic symptoms (DRESS), and epidermal necrolysis (Stevens-Johnson syndrome [SJS], toxic epidermal necrolysis). The identification of the causal drug is crucial in order to avoid further exposure, but making the right differential diagnosis of the type of SCAR is equally important since treatment, follow-up, and prognosis of different SCARs are not the same. These syndromes are distinct entities with different clinical, biological, and histological p

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Markaryan, N. M., R. A. Vandysheva, N. V. Nizyaeva, et al. "Clinical and morphological assessment of uterine scars after cesarean section in patients with gynecological and extragenital diseases." CLINICAL AND EXPERIMENTAL MORPHOLOGY 12, no. 1 (2023): 34–45. http://dx.doi.org/10.31088/cem2023.12.1.34-45.

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Introduction. The article studies excised scars on the uterus after Gusakov’s and Stark’s cesarean sections, with an assessment of the impact of gynecological and extragenital diseases on the viability of the scar. Cesarean scar pregnancy is known to be a frequent indication for surgical delivery. However, if the uterine scar is stable, it is advisable to deliver the baby through the natural birth canal. At present, natural delivery of pregnant women with a scar on the uterus through natural childbirth is an important task in modern obstetrics. Thus, the aim of our study was to perform a multi

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Avetikov, D. S., O. P. Bukhanchenko, I. O. Ivanytsky, N. A. Sokolova, and I. V. Boyko. "EXPERIENCE OF USING DIGITAL SYSTEMS FOR DIAGNOSTICS OF HYPERTROPHIC SKIN SCARS OF FACE." Ukrainian Dental Almanac, no. 2 (June 25, 2018): 13–16. http://dx.doi.org/10.31718/2409-0255.2.2018.03.

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The relevance of the problem. Head and neck scars resulting from the effects of various endogenous and exogenous factors are an actual problem of modern surgical stomatology. A large number of scientific researches devoted to the study of different methods of diagnosis of head and neck scars indicates that the verification of the diagnosis is a highly complicated issue. Currently, conventional algorithms for selecting methods of treating patients with scars are available. The development of such algorithm is difficult due to the uncertainty of criteria for the differential diagnosis of various

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Zuccaro, Jennifer, Joel Fish, and Charis Kelly. "29 The Effectiveness of Laser Therapy for Hypertrophic Burn Scars in Pediatric Patients: A Prospective Investigation." Journal of Burn Care & Research 42, Supplement_1 (2021): S24—S25. http://dx.doi.org/10.1093/jbcr/irab032.034.

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Abstract Introduction Laser therapy has emerged as a valuable treatment option for hypertrophic burn scars over the past decade. Improvements in scar symptoms have been found using the ablative fractional carbon dioxide laser (AFCL) as well as the pulsed dye laser (PDL). However, research regarding the use of laser therapy among pediatric burn patients remains limited. Thus, the aim of this study was to investigate the effectiveness of using laser therapy to improve hypertrophic burn scars in a pediatric population using a comprehensive set of subjective and objective scar assessment tools. Me

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Aoki, Masayo, Akatsuki Kondo, Noriko Matsunaga, et al. "The Immunosuppressant Fingolimod (FTY720) for the Treatment of Mechanical Force-Induced Abnormal Scars." Journal of Immunology Research 2020 (January 7, 2020): 1–11. http://dx.doi.org/10.1155/2020/7057195.

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Aim. Abnormal scars such as hypertrophic scars (HSs) and keloids are excessively growing scars that exhibit chronic inflammation and capillary vasculogenesis. The lipid mediator sphingosine-1-phosphate (S1P) is important in inflammatory cell recruitment and angiogenesis. Fingolimod (FTY720) is an analog of S1P and thus functionally antagonizes S1P receptors and inhibits the enzyme that produces S1P. We examined the effects of topical FTY720 injections on mechanical force-induced HS progression. Methods. Mechanical force-induced HSs were generated in C57BL6/J mice by suturing a dorsal incision

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Morhenn, Vera B., and B. R. Smoller. "Immunophenotyping of a Sarcoidal Granuloma in a Scar, a Manifestation of a Possible Autoimmune Process." Journal of Cutaneous Medicine and Surgery 3, no. 1 (1998): 46–48. http://dx.doi.org/10.1177/120347549800300113.

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Background: Old scars rarely develop sarcoid lesions. To determine whether the immunophenotype of the cellular infiltrate found in sarcoid in scarred skin resembled that seen in sardoidosis, we performed routine staining with hematoxylin and eosin, as well as immunophenotyping of a sarcoid lesion in a scar. Currently, there is controversy about the etiology of sarcoidosis in general and about sarcoidal granulomas in scars in particular. A new hypothesis is suggested in this case report. Objective: The purpose was to determine whether the cellular infiltrate in a sarcoidal granuloma in an old s

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Magdalena, Juana, Thomas H. Millard, Sandrine Etienne-Manneville, Sophie Launay, Helen K. Warwick, and Laura M. Machesky. "Involvement of the Arp2/3 Complex and Scar2 in Golgi Polarity in Scratch Wound Models." Molecular Biology of the Cell 14, no. 2 (2003): 670–84. http://dx.doi.org/10.1091/mbc.e02-06-0345.

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Cell motility and cell polarity are essential for morphogenesis, immune system function, and tissue repair. Many animal cells move by crawling, and one main driving force for movement is derived from the coordinated assembly and disassembly of actin filaments. As tissue culture cells migrate to close a scratch wound, this directional extension is accompanied by Golgi apparatus reorientation, to face the leading wound edge, giving the motile cell inherent polarity aligned relative to the wound edge and to the direction of cell migration. Cellular proteins essential for actin polymerization down

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Joseph, Santhosh, Gonnabaktula Naga Vasanthalakshmi, Usha Vishwanath, and M. Anitha. "Successful Management of a Scary Case of Cesarean Scar Pregnancy with Combined Treatment using Methotrexate, Uterine Artery Embolization and Suction Evacuation." Journal of South Asian Federation of Obstetrics and Gynaecology 7, no. 3 (2015): 143–47. http://dx.doi.org/10.5005/jp-journals-10006-1344.

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ABSTRACT Cesarean scar pregnancy (CSP) is the rarest type of ectopic pregnancy implanted in the myometrium at the site of the previous cesarean section scar. It may lead catastrophic complications like uterine rupture and uncontrollable hemorrhage.4 Early diagnosis can offer treatment options of avoiding uterine rupture and hemorrhage, thus, preserving the uterus and future fertility. The conservative treatment can be by local and/or systemic administration of methotrexate, dilatation and curettage, excision of trophoblastic tissues (laparoscopy/laparotomy), bilateral internal artery ligation

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Mei, Zepeng, Keyan Fang, Qichao Yao, et al. "An Alternative Method for Dating of Wildfire Occurrence from Tree-Ring Cores: A Case Study in Northeastern Asia." Forests 14, no. 9 (2023): 1780. http://dx.doi.org/10.3390/f14091780.

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The tree-ring fire scar stands as a pivotal proxy for reconstructing historical wildfire occurrences, providing invaluable context for comprehending contemporary wildfire activities during the Anthropocene era. Precise identification of fire scars often necessitates sampling complete tree disks. Yet, stringent forest resource protection policies limit such collection in certain regions, thus curtailing the application of tree-ring-based fire reconstruction. While current methods based on tree-ring cores can ascertain the age range of fire events, pinpointing the exact year remains challenging.

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Darmaputra, I. Gusti Nyoman. "Tatalaksana Terkini Skar Atrofi: Sebuah Tinjauan Literatur." Intisari Sains Medis 15, no. 2 (2024): 504–12. http://dx.doi.org/10.15562/ism.v15i2.2034.

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Scars are the culmination of the natural healing and reparative process resulting from the formation of dermal fibrotic scars following inflammation. Atrophic scars are widely characterized by generalized skin atrophy resulting in the loss of skin cells in the epidermis, clinically appearing as the loss of normal dermis. Atrophic scars occur more frequently than hypertrophic and keloid scars, with a ratio of 3:1.9. Atrophic scars present a significant challenge for reconstructive specialists, thus becoming a topic worthy of continuous study based on the latest consensus. The management of atro

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Bird, Cole, Manal Hassan, Jacob Cindrich, and Dhaval Bhavsar. "685 Patient Satisfaction with Deep Fractional Laser Treatment for Burn Scars in an Outpatient Setting." Journal of Burn Care & Research 46, Supplement_1 (2025): S241. https://doi.org/10.1093/jbcr/iraf019.314.

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Abstract Introduction An estimated 486,000 burn injuries requiring medical treatment occur each year, often leading to severe morbidity due to scarring. CO2 laser treatments have become essential for addressing hypertrophic burn scars (HBS). CO2 fractional ablative laser (FAL) treatments usually require use of sedation due to significant pain involved with the procedure. We are using Er:YSGG FAL in select patients in office setting. This study provides outcomes for use of office based burn hypertrophic scar remodeling using Er:YSGG FAL. Methods Patients with symptomatic HBS were offered YSGG F

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Nugraha, Andri, Rizal Chaidir, Urip Rahayu, and Santi Rinjani. "FACTORS INFLUENCING THE OCCURRENCE OF HYPERTROPHIC SCARS AMONG POSTOPERATIVE PATIENTS IN GARUT, INDONESIA." Belitung Nursing Journal 3, no. 1 (2017): 23–31. http://dx.doi.org/10.33546/bnj.44.

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Background: Hypertrophic scar causes physical and psychological problems. Thus understanding the factors related to the occurrence of hypertrophic scar tissue is needed. Little is known about its influencing factors in Indonesia, especially in Garut.Objective: This study aims to examine the relationships between hypertrophic scar and its influencing factors, and identify the most dominant factor of the occurrence of hypertrophic scars.Methods: This was an observational case control study using retrospective approach in Polyclinic of Surgery of Regional Public Hospital of dr. Slamet of Garut Re

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Diksha, Gulati, Gupta Monika, Saini Namita, Kaur Manpreet, and Kaur Amandeep. "Review on various combination therapies for the treatment of Hypertrophic scars and keloids." YMER Digital 21, no. 08 (2022): 841–47. http://dx.doi.org/10.37896/ymer21.08/71.

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Keloids and hypertrophic scars are mild proliferative growth of dermal collagen that results in various physical, physiological and cosmetic concerns. Till the date the basis behind the formation of these scars has not been fully defined, it is assumed that keloids- and hypertrophic scar-derived fibroblasts produce increased amount of collagen per cell compared with normal fibroblast. Thus suppression of the fibroblast becomes the basic approach for therapeutic treatment of the wound responses. There is no permanent treatment for ablation of keloids and hypertrophic scars. A large number of tr

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Powell, Chris D., David E. Quain, and Katherine A. Smart. "Chitin scar breaks in aged Saccharomyces cerevisiae." Microbiology 149, no. 11 (2003): 3129–37. http://dx.doi.org/10.1099/mic.0.25940-0.

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Ageing in budding yeast is not determined by chronological lifespan, but by the number of times an individual cell is capable of dividing, termed its replicative capacity. As cells age they are subject to characteristic cell surface changes. Saccharomyces cerevisiae reproduces asexually by budding and as a consequence of this process both mother and daughter cell retain chitinous scar tissue at the point of cytokinesis. Daughter cells exhibit a frail structure known as the birth scar, while mother cells display a more persistent bud scar. The number of bud scars present on the cell surface is

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Ma, Juan, Xianglin Dong, and Bo Zhang. "Effect and mechanism of action of botulinum toxin type A on hypertrophic scar <i>in vitro</i>." Tropical Journal of Pharmaceutical Research 22, no. 11 (2024): 2305–10. http://dx.doi.org/10.4314/tjpr.v22i11.9.

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Purpose: To examine the effect of botulinum toxin type A (BTXA) on the formation of hypertrophic scar and to unravel its mechanism of action. Methods: HSF cells were isolated from hypertrophic scars and cultured. Immunohistochemistry (IHC) assays were performed to determine TGF-β1, FN, and Col1 expressions in hypertrophic scar and normal tissues while the expressions and phosphorylation of p38, ERK, JNK, as well as the expressions of α-SMA, Col1 and FN1 in HSF cells were evaluated by immunoblot techniques. CCK-8 and Transwell assays were used to assess the effect of BTXA on the viability

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Nur Rohmah, Restu. "Microneedling dengan Platelet-rich Plasma (PRP) untuk Skar Akne Atrofi." Cermin Dunia Kedokteran 48, no. 9 (2021): 380–85. http://dx.doi.org/10.55175/cdk.v48i9.135.

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Skar atrofi merupakan komplikasi umum akne dan sangat memengaruhi kualitas hidup pasien. Microneedling dengan PRP untuk memperbaiki skar akne atrofi tergolong sederhana, aman, dan efektif. Teknik ini menggunakan jarum mikro untuk menusuk kulit secara superfisial dan menghancurkan kolagen rusak di lapisan atas dermis, mengaktivasi kaskade penyembuhan luka secara normal yang menstimulasi pembentukan kolagen baru sehingga memperbaiki tampilan skar. Artikel ini memaparkan microneedling dengan PRP sebagai modalitas terapi untuk skar akne atrofi. Atrophic scars are common acne complication and

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Pershina, E. S., V. E. Sinitsin, E. A. Mershina, M. A. Komarova, and A. S. Chaban. "Static Myocardial Dual-Energy (DE) Perfusion and Delayed Enhancement in Detection of Chronic Myocardial Scar Tissue. Comparison with Late Gadolinium Ebhancement MRI." Medical Visualization, no. 4 (August 28, 2017): 10–18. http://dx.doi.org/10.24835/1607-0763-2017-4-10-18.

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Purpose. To compare the performance of static myocardialDECT perfusion imaging (CTA) with DECT delayed enhancement for detection of ischemic myocardial scars using LGE MRI as a diagnostic standard.Materials and Methods. 29 patients (m/f –16/13 mean age 57.6 ± 2.1) with chronic myocardial infarction were prospectively enrolled in the study. The CCTA protocol consisted of prospectively gated static myocardial DECT perfusion imaging (angiographic phase) and DECT delayed enhancement with 8 min delay after contrast media injection. Study was performed with 64-row single-source dual energy CT with f

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Cho, Hoyu, Shimpei Ono, and Kevin C. Chung. "Management of Scar Contractures of the Hand—Our Therapeutic Strategy and Challenges." Journal of Clinical Medicine 13, no. 5 (2024): 1516. http://dx.doi.org/10.3390/jcm13051516.

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The essence of treating scar contractures lies in covering the skin deficit after releasing the contractures, typically using flaps or skin grafts. However, the specific characteristics of scar contractures, such as their location, shape, and size, vary among patients, which makes surgical planning challenging. To achieve excellent outcomes in the treatment of scar contractures, we have developed a dimensional classification system for these contractures. This system categorizes them into four types: type 1 (superficial linear), type 2-d (deep linear), type 2-s (planar scar contractures confin

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Yang, Chae-Eun, Sewoon Choi, Ju Hee Lee, et al. "Sustained Release of Decoy Wnt Receptor (sLRP6E1E2)-Expressing Adenovirus Using Gel-Encapsulation for Scar Remodeling in Pig Model." International Journal of Molecular Sciences 21, no. 6 (2020): 2242. http://dx.doi.org/10.3390/ijms21062242.

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An adenoviral vector (Ad) expressing a Wnt decoy receptor (sLRP6E1E2) is known to induce an anti-fibrotic effect by inhibiting Wnt signaling. We evaluated its effects in vivo using pig models and attempted to introduce an alginate gel-matrix system to prolong the effect of the Ad. Transduction efficiency as to the biological activity of Ad in different forms was evaluated. Then, 50 days after the formation of full-thickness skin defects on the backs of Yorkshire pigs, scars were treated with each form of Ad. Therapeutic efficacy and various factors influencing scar formation and collagen rearr

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Rohmah, Restu Nur. "Microneedling dengan Platelet-rich Plasma (PRP) untuk Skar Akne Atrofi." Cermin Dunia Kedokteran 48, no. 9 (2021): 380. http://dx.doi.org/10.55175/cdk.v48i9.1500.

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<p>Skar atrofi merupakan komplikasi umum akne dan sangat memengaruhi kualitas hidup pasien. Microneedling dengan PRP untuk memperbaiki skar akne atrofi tergolong sederhana, aman, dan efektif. Teknik ini menggunakan jarum mikro untuk menusuk kulit secara superfisial dan menghancurkan kolagen rusak di lapisan atas dermis, mengaktivasi kaskade penyembuhan luka secara normal yang menstimulasi pembentukan kolagen baru sehingga memperbaiki tampilan skar. Artikel ini memaparkan microneedling dengan PRP sebagai modalitas terapi untuk skar akne atrofi.</p><p>Atrophic scars are common

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Ahmad, Nura, Alexandra Anker, Silvan Klein, et al. "Autologous Fat Grafting—A Panacea for Scar Tissue Therapy?" Cells 13, no. 16 (2024): 1384. http://dx.doi.org/10.3390/cells13161384.

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Scars may represent more than a cosmetic concern for patients; they may impose functional limitations and are frequently associated with the sensation of itching or pain, thus impacting both psychological and physical well-being. From an aesthetic perspective, scars display variances in color, thickness, texture, contour, and their homogeneity, while the functional aspect encompasses considerations of functionality, pliability, and sensory perception. Scars located in critical anatomic areas have the potential to induce profound impairments, including contracture-related mobility restrictions,

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Lee, Geoffrey, David J. Hunter-Smith, and Warren Matthew Rozen. "Autologous fat grafting in keloids and hypertrophic scars: a review." Scars, Burns & Healing 3 (January 1, 2017): 205951311770015. http://dx.doi.org/10.1177/2059513117700157.

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Keloid and hypertrophic scars are unique human dermal fibroproliferative disorders of the injured skin and are associated with pain, itch and can cause functional limitations. A number of genetic, systemic and local factors have been identified in the formation of keloids and hypertrophic scars. Studies have shown that adipose-derived stem cells have angiogenic and antiapoptotic properties which has effects on wound healing, soft-tissue restoration and scar remodelling, and thus may have a role in managing keloid scaring. However, this role is not well described in the literature. A systemic r

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Edger-Lacoursière, Zoë, Elisabeth Marois-Pagé, Ana de Oliveira, M. Réadaptation, Valérie Calva, and Bernadette Nedelec. "536 Objective Quantification of Hypertrophic Scar and Donor Scar between 2 to 7 months Post-burn Injury." Journal of Burn Care & Research 43, Supplement_1 (2022): S103. http://dx.doi.org/10.1093/jbcr/irac012.165.

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Abstract Introduction Very few objective scar evaluations have been conducted with the burn survivor population, which limits our knowledge of the clinical recovery profile of hypertrophic scars (HSc) and donor site scars (D), thus having an impact on rehabilitation intervention and treatment prioritization. The purpose of this study was to prospectively quantify the thickness, pliability, erythema and pigmentation of post-burn HSc, donor sites (normal scar) and normal skin in different anatomical locations between 2 and 7 months post-burn using objective instrumentation. A secondary objective

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Baranov, І.V., N.M. Nor, S.V. Slesarenko, P.О. Badiul, and К.V. Tsyhankov. "Morphological features of skin scars on the background of treatment with autologous adipocytes." Medicni perspektivi 25, no. 3 (2020): 96–104. https://doi.org/10.26641/2307-0404.2020.3.214822.

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So far the pathogenesis of changes and reconstruction of recipient tissues after transplantation of autologous adipocytes have not been studied sufficiently. The purpose of the research was to carry out the estimation of efficiency and morphological grounding of the surgery of transplanting autologous adipocytes for treating skin scars. The study included 35 patients (12 males and 23 females at the age of 18-55 years) with skin scars after deep burns. The majority of patients were with atrophic scars – 25 (71.4%); with hypertrophic – 8 (22.9%); with normotrophic – 2 (5.7

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Sheoran, Khushboo, Urmil Chawla, Divya Srivastava, et al. "Paradigms in periorbital scar management." IP International Journal of Ocular Oncology and Oculoplasty 10, no. 3 (2024): 117–28. http://dx.doi.org/10.18231/j.ijooo.2024.024.

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Periocular scarring following surgery or trauma is of great aesthetic and functional concern and is difficult to predict. In today’s era, with increasing scientific knowledge and technological advances, both physicians and their patients are highly concerned with minimizing scar appearance as a rising number of patients feel disappointed with their scars and are frequently seeking help for functional and aesthetic improvement. Although various non-surgical and surgical treatment strategies are available it is still difficult to improve excessive scarring. Thus, the importance of thorough knowl

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Li, Yeyang, Gang Li, Xiao Hu, et al. "Integrin-Linked Kinase Senses Hypoxia During Scar Angiogenesis." International Journal of Lower Extremity Wounds 15, no. 4 (2016): 286–95. http://dx.doi.org/10.1177/1534734616649485.

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Integrin-linked kinase (ILK) mediates signal transduction between cells and the extracellular matrix, regulating cell proliferation, migration, angiogenesis, and apoptosis. However, its roles in the formation of hypertrophic scars are not yet clear. In this study, we found that ILK was predominantly expressed on the microvascular endothelial cells and the epidermal basal cells of human hypertrophic scars. The proliferation, migration and angiogenesis of primary human scar microvascular endothelial cells (HSMECs) were significantly inhibited after ILK was silenced. The ILK inhibitor QLT0267 had

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Verzella, Alexandra N., Matteo Laspro, Allison Diaz, et al. "Comparison of the Effects of Postoperative Arm Restraints and Mittens on Cleft Lip Scar Quality after Primary Repair." Journal of Clinical Medicine 13, no. 13 (2024): 3619. http://dx.doi.org/10.3390/jcm13133619.

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Introduction: Postoperative management following primary cleft lip repair varies across institutions, cleft care teams, and individual surgeons. Postoperative precautions employed after cleft lip repair include dietary restrictions, pacifier limitations, and immobilization, with arm restraints long being used. Yet, restraint distress has led to the exploration of other forms of immobilization. Thus, this study aims to assess cleft lip scar quality and complication rates after postoperative immobilization with arm restraints versus hand mittens. Methods: A retrospective review of patients with

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Parry, Ingrid, Soman Sen, Tina L. Palmieri, David G. Greenhalgh, and Kathleen S. Romanowski. "117 Feasibility and Scar Outcome with a Single-use Adhesive Silicone in Pediatric Burn Survivors." Journal of Burn Care & Research 42, Supplement_1 (2021): S78. http://dx.doi.org/10.1093/jbcr/irab032.121.

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Abstract Introduction Silicone sheets are commonly used for prevention and treatment of burn scars and silicone-based products have recently been recommended as the gold standard non-invasive treatment choice. One problem with silicone gel sheets application is that the sheets lose their adhesive qualities making them difficult to affix to the patient and costly to replace when lost. A new ultra-thin, clear and adhesive silicone gel sheet layered on a semi-permeable polyester backing was trialed at our burn center. The silicone is designed to be a one-time application, worn during all activiti

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Jung, Bok Ki, Tai Suk Roh, Hyun Roh, Ju Hee Lee, Chae-Ok Yun, and Won Jai Lee. "Effect of Mortalin on Scar Formation in Human Dermal Fibroblasts and a Rat Incisional Scar Model." International Journal of Molecular Sciences 23, no. 14 (2022): 7918. http://dx.doi.org/10.3390/ijms23147918.

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Wound healing is a complicated cascading process; disequilibrium among reparative processes leads to the formation of pathologic scars. Herein, we explored the role of mortalin in scar formation and its association with the interleukin-1α receptor using in vitro and in vivo models. To investigate the effects of mortalin, we performed an MTT cell viability assay, qRT-PCR, and Western blot analyses, in addition to immunofluorescence and immunoprecipitation studies using cultured fibroblasts. A rat incisional wound model was used to evaluate the effect of a mortalin-specific shRNA (dE1-RGD/GFP/sh

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Major, K. M., F. D. Bodog, and O. L. Pop. "A comparative clinical study of the treatment of hypertrophic scars with intralesional steroid and silicone gel sheeting in different types of incision lines in caesarean sections." Medicine in Evolution 29, no. 1 (2023): 1–6. http://dx.doi.org/10.70921/medev.v29i1.1027.

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Caesarean section is one of the most common interventions in obstetrics and gynecology today. Complications of scar healing and also the aesthetics of the scar is usually very important for patients. 96 patients were selected to participate in this study after giving birth by caesarean section. Each group included 24 patients, who underwent a Pfannenstiel section or a transverse laparotomy incision. The patients were treated with either intralesional steroid or silicone gel sheeting. The aim of this study was to compare and determine the roles of these two commonly used treatment options of hy

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Pekny, Milos, Clas B. Johansson, Camilla Eliasson, et al. "Abnormal Reaction to Central Nervous System Injury in Mice Lacking Glial Fibrillary Acidic Protein and Vimentin." Journal of Cell Biology 145, no. 3 (1999): 503–14. http://dx.doi.org/10.1083/jcb.145.3.503.

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In response to injury of the central nervous system, astrocytes become reactive and express high levels of the intermediate filament (IF) proteins glial fibrillary acidic protein (GFAP), vimentin, and nestin. We have shown that astrocytes in mice deficient for both GFAP and vimentin (GFAP−/−vim−/−) cannot form IFs even when nestin is expressed and are thus devoid of IFs in their reactive state. Here, we have studied the reaction to injury in the central nervous system in GFAP−/−, vimentin−/−, or GFAP−/−vim−/− mice. Glial scar formation appeared normal after spinal cord or brain lesions in GFAP

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Faydhulla, Shadia Ahmed, Srwa Jamal Murad, and Chro Najmadeen Fattah. "Different Treatment Modalities for Cesarean Scar Pregnancies in Sulaimani Maternity Teaching Hospital." Advanced medical journal 10, no. 2 (2025): 77–84. https://doi.org/10.56056/amj.2025.345.

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Background and objectives: Cesarean scar ectopic pregnancy is one of the most severe complications of cesarean delivery. Thus, we aimed to evaluate the cesarean scar ectopic pregnancy and treatment modalities. Methods: A cross-sectional study was conducted on 30 cesarean scar ectopic pregnant women who attended the Sulaimani Maternity Teaching Hospital, from May 2022 to May 2023. The cesarean scar ectopic pregnancy among studied women was diagnosed with ultrasound, and then a validated questionnaire was used to collect their sociodemographic and clinical data. Blood samples were collected to e

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Tremblay, Chloe, Stephanie Jean, Genevieve Schneider, Bernadette Nedelec, and Zoë Edger-Lacoursière. "770 Rehabilitation Evaluation and Treatment for the Management of Skin Graft Complication of the Genitalia." Journal of Burn Care & Research 45, Supplement_1 (2024): 241. http://dx.doi.org/10.1093/jbcr/irae036.311.

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Abstract Introduction Skin graft complications can include pain, contractures, hypertrophic scars, sensitivity issues, recurrent wounds and infections. Genitalia, perineum and/or buttocks graft complications have a direct impact on walking, sitting, voiding, bowel elimination, sexual function, intimacy, thereby reducing quality of life. Perineal and pelvic rehabilitation is used for many pelvic floor disorders, however, has not been described after burn injury or necrotizing fasciitis. Thus, this case report describes, a new rehabilitation evaluation template following perineal grafting and tr

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Koller, Thomas. "Mechanosensitive Aspects of Cell Biology in Manual Scar Therapy for Deep Dermal Defects." International Journal of Molecular Sciences 21, no. 6 (2020): 2055. http://dx.doi.org/10.3390/ijms21062055.

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Deep dermal defects can result from burns, necrotizing fasciitis and severe soft tissue trauma. Physiological scar restriction during wound healing becomes increasingly relevant in proportion to the affected area. This massively restricts the general mobility of patients. External mechanical influences (activity or immobilization in everyday life) can lead to the formation of marked scar strands and adhesions. Overloading results in a renewed inflammatory reaction and thus in further restriction. Appropriate mechanical stimuli can have a positive influence on the scar tissue. “Use determines f

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Akdeniz, Mujde, Claudia Alessandra Manetti, Koopsen Tijmen, et al. "Deep Learning for Multi-Level Detection and Localization of Myocardial Scars Based on Regional Strain Validated on Virtual Patients." IEEE Access 11 (February 3, 2023): 15788–98. https://doi.org/10.1109/access.2023.3243254.

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How well the heart is functioning can be quantified through measurements of myocardial deformation via echocardiography. Clinical assessment of cardiac function is generally focused on global indices of relative shortening, however, territorial, and segmental strain indices have shown to be abnormal in regions of myocardial disease, such as scar. In this work, we propose a single framework to predict myocardial disease substrates at global, territorial, and segmental levels using regional myocardial strain traces as input to a convolutional neural network (CNN)-based classification algorithm.

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Dwertman, Michelle, Dr Henry Huson, and Kelly Spiller. "682 A Unique Mouth Orthosis for Management of Microstomia." Journal of Burn Care & Research 46, Supplement_1 (2025): S239. https://doi.org/10.1093/jbcr/iraf019.311.

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Abstract Introduction Microstomia occurs following facial burns with scarring or trauma, causing difficulties with eating, speaking, and oral hygiene. Treatment options vary and orthosis are limited. Some orthoses offer a linear, unidirectional stretch of the mouth opening, lacking verticality and thus the ability to address the oral facial complex of larger facial burns. Secondly, large orthoses are heavy, require dexterity, are hard to sustain a long stretch and thus have decreased adherence. This problem prompted a novel solution: a semirigid oral orthosis made of flexible silicone, lightwe

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O’Boyle, Ciaran P., Holleh Shayan-Arani, and Maha Wagdy Hamada. "Intralesional cryotherapy for hypertrophic scars and keloids: a review." Scars, Burns & Healing 3 (January 1, 2017): 205951311770216. http://dx.doi.org/10.1177/2059513117702162.

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Introduction: Hypertrophic and keloid scarring remain notoriously troublesome for patients to tolerate and frustratingly difficult for clinicians to treat. Many different treatment modalities exist, signifying the failure of any method to achieve consistently excellent results. Intralesional cryotherapy is a relatively recent development that uses a double lumen needle, placed through the core of a keloid or hypertrophic scar, to deliver nitrogen vapour, which freezes the scar from its core, outwards. Methods: This article provides a comprehensive review of the literature on intralesional cryo

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Kwon, Jin Geun, Dae Won Hong, Hyunsuk Peter Suh, Changsik John Pak, and Joon Pio Hong. "Patient-specific surgical options for breast cancer-related lymphedema: technical tips." Archives of Plastic Surgery 48, no. 3 (2021): 246–53. http://dx.doi.org/10.5999/aps.2020.02432.

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In order to provide a physiological solution for patients with breast cancer-related lymphedema (BCRL), the surgeon must understand where and how the pathology of lymphedema occurred. Based on each patient’s pathology, the treatment plan should be carefully decided and individualized. At the authors’ institution, the treatment plan is made individually based on each patient’s symptoms and relative factors. Most early-stage patients first undergo decongestive therapy and then, depending on the efficacy of the treatment, a surgical approach is suggested. If the patient is indicated for surgery,

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Merdekios, Behailu, Misgun Shewangizaw, Abebayehu Sappo, et al. "Unveiling the hidden burden: Exploring the psychosocial impact of cutaneous leishmaniasis lesions and scars in southern Ethiopia." PLOS ONE 20, no. 2 (2025): e0317576. https://doi.org/10.1371/journal.pone.0317576.

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Background Cutaneous leishmaniasis (CL) poses a major public health concern in Ethiopia, with lesions and scars commonly affecting exposed body parts, resulting in physical, social, and psychological consequences. This study aims to assess the psychosocial impacts of CL, shedding light on the experiences and perceptions of affected individuals, thus contributing to the knowledge on Cutaneous leishmaniasis in Ethiopia and informing public health interventions to address its psychosocial effects. Methods Using a descriptive phenomenological design, the study explored the lived experiences of ind

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Ramsfield, Tod D., Simon F. Shamoun, Zamir K. Punja, and William E. Hintz. "Variation in the mitochondrial DNA of the potential biological control agent Chondrostereum purpureum." Canadian Journal of Botany 77, no. 10 (2000): 1490–98. http://dx.doi.org/10.1139/b99-125.

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The mitochondrial DNA (mtDNA) of Chondrostereum purpureum (Pers.:Fr.) Pouzar was extracted and purified, and the size ranged from 51.8 to 66.4 kb. One isolate each from British Columbia, Alberta, Finland, the Netherlands, and New Zealand were found to have identical BamHI mtDNA restriction patterns, resulting in a mitochondrial genome of 63.8 kb. An additional isolate from British Columbia and one from Switzerland had different banding patterns, however, resulting in mitochondrial genomes of 66.4 kb and 51.8 kb, respectively. A sequence-characterized amplified region (SCAR) assay, based on a p

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Zhelezov, D. M., and T. O. Savenko. "UTERINE SCAR FORMATION AND EXPRESSION OF SPECIFIC CONNECTIVE TISSUE PROTEINS." Актуальні питання педіатрії, акушерства та гінекології, no. 1 (November 4, 2020): 132–36. http://dx.doi.org/10.11603/24116-4944.2020.1.11498.

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The aim of the study – to evaluate the role of expression of specific connective tissue proteins in the formation of the scar on the uterus. Materials and Methods. The study was performed on the basis of the regional perinatal center and KU PB No. 5 during 2017–2019. 426 women with a scar on the uterus were examined, including 115 (27.0 %) with two or more scars. The mean age of the subjects was (33.4±1.1) years. The results of sonographic studies were analyzed. For pathomorphological examination, three cases of intranatal rupture of the uterine wall along the “old” scar after cesarean s

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Scala, Jacopo, Aleksandra Vojvodic, Petar Vojvodic, et al. "Botulin Toxin Use in Scars/Keloids Treatment." Open Access Macedonian Journal of Medical Sciences 7, no. 18 (2019): 2979–81. http://dx.doi.org/10.3889/oamjms.2019.783.

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Botulinum toxin (BTX) is a neurotoxin protein derived from the Clostridium botulinum bacterium that inhibits the release of acetylcholine at the neuromuscular junction level whose effects has been used for many years to treat a variety of muscular/neuromuscular conditions and more recently also for cosmetic use. BTX has experimented in some dermatological conditions which include scar prevention and treatment with good results. The complex mechanism underlying those results is not completely understood but several mechanisms were proposed: release inhibition of different substances like

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Chene, G., C. Darcha, P. Dechelotte, G. Mage, and M. Canis. "Malignant degeneration of perineal endometriosis in episiotomy scar, case report and review of the literature." International Journal of Gynecologic Cancer 17, no. 3 (2007): 709–14. http://dx.doi.org/10.1136/ijgc-00009577-200705000-00022.

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Although malignant degeneration of cutaneous endometriosis is rare at only 0.3–1% in endometriosis surgical scars, diagnosis and management need to be defined. A case of malignant degeneration of perineal endometriosis is reported, with a review of literature. Physiopathology, epidemiological data, diagnostic and therapeutic methods are discussed for malignant degeneration of cutaneous endometriosis. Any scar lesion that evolves in response to the menstrual cycle should be considered endometriosis until proven otherwise, and thus could require surgical resection, with histological analysis. A

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Chinyere, Tyler Chinedu, and Ikeotunye Royal Chinyere. "Management of Left Atrial Tachyrhythms in the Setting of HFpEF with Pulsed-Field Ablation: Treating Fire with Water?" Therapeutics 1, no. 1 (2024): 42–51. http://dx.doi.org/10.3390/therapeutics1010006.

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Atrial fibrillation (AF) in the setting of heart failure (HF) with preserved ejection fraction (HFpEF) is a prevalent comorbidity and is enabled by adverse left atrial (LA) remodeling, dilation, and scar tissue formation. These changes are facilitated by poor left ventricular compliance. A growing body of clinical evidence and medical guidelines suggest that managing atrial tachyrhythms with catheter ablation (CA) is paramount to treating concomitant HF. This recommendation is complicated in that thermal CA modalities, namely radiofrequency ablation and cryoablation, are both therapeutic via i

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Lokes, Kateryna P., David S. Avetikov, Oksana V. Klitynska, Pavlo P. Brekhlichuk, and Yana I. Bun. "THE HISTOTOPOGRAPHIC FEATURES OF FORMATION OF KELOID SCARS OF MAXILLOFACIAL LOCALIZATION." Wiadomości Lekarskie 73, no. 3 (2020): 565–68. http://dx.doi.org/10.36740/wlek202003131.

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The aim: Study of the influence of local oxygen deficiency on the features of the formation of keloid scars of the head and neck. Materials and methods: The research material was 17 incisional biopsy specimens of keloid scars, which were the highest age categories of patients from 19 to 63 years. Results: It was revealed that at coloring according to Mallory’s technique, sections of fibrinoid swelling of collagen fibers were noted near central homogeneous hyaline masses. The lateral areas of the dermis that adjacent to keloid scar tissue, at coloring by the Hart method, in our modification, we

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