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Dissertations / Theses on the topic 'Scas02'

Author: Grafiati

Published: 28 July 2024

Last updated: 31 July 2025

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1

Peters, Judith [Verfasser]. "Identifizierung und Charakterisierung neuer Interaktionspartner des lysosomalen integralen Membranproteins Typ-2 (LIMP-2/SCARB2) / Judith Peters." Kiel : Universitätsbibliothek Kiel, 2018. http://d-nb.info/1153768445/34.

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2

Wesseler, Sophia Charlotte [Verfasser]. "Charakterisierung des Promotors des Gens für das Lysosomale Integrale Membranprotein Typ-2 (LIMP-2/SCARB2) / Sophia Charlotte Wesseler." Kiel : Universitätsbibliothek Kiel, 2017. http://d-nb.info/1142154742/34.

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3

Bampi, Giovana Bavia. "Estudo de haplótipos em famílias com ataxia espinocerebelar tipo 10(SCA10) : evidências de um efeito fundador da mutação." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/119618.

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A ataxia espinocerebelar tipo 10 (SCA10) é uma doença neurodegenerativa rara de herança autossômica dominante caracterizada por atrofia cerebelar com alterações da marcha e, em alguns casos, convulsões. A SCA10 é causada por expansões de repetições pentanucleotídicas ATTCT no íntron 9 do gene ATXN10, o qual se localiza no locus 22q13. Alelos normais apresentam entre 10 a 29 repetições e o alelo patogênico apresenta entre 800 a 4.500 repetições. Até o momento, casos de SCA10 foram descritos apenas em pacientes miscigenados de países do continente americano como México, Brasil, Argentina, Venezu

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4

Öhlund, Rebecca. "Könsskillnader i välbefinnande utifrån val av fysisk aktivitet." Thesis, Örebro universitet, Institutionen för juridik, psykologi och socialt arbete, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-43343.

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Samhället uppmuntrar individer att se över sina hälsovanor för att öka välbefinnandet. Syftet var att undersöka om val av fysisk aktivitet hade effekt på den generella hälsan i ökat subjektivt välbefinnande samt om det fanns könsskillnader i dessa. Sextio män och kvinnor mellan 25-50 år valdes slumpmässigt ut från träningsanläggningar för att besvara the 12-item General Health Questionnaire (GHQ-12) samt Swedish Core Affect Scale (SCAS). Resultatet visade på signifikant ökning av välbefinnande efter fysisk aktivitet samt inga könsskillnader. Dock fanns en signifikant interaktionseffekt mellan

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5

Satterfield, Terrence Forrest. "Genetic and biochemical analysis of the Drosophila melanogaster homolog of the human SCA2 gene /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/10245.

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6

Patterson, Erika K. "The social class attitudes scale (SCAS) : instrument development and estimates for reliability and validity /." free to MU campus, to others for purchase, 2003. http://wwwlib.umi.com/cr/mo/fullcit?p3099621.

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7

Ngwamidiba, Maxime. "Etude moléculaire des gènes SCA1 et SCA2 codant des protéines autotransporteurs chez les membres du genre " rickettsia"." Aix-Marseille 2, 2006. http://www.theses.fr/2006AIX20660.

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Des analyses d'ADN sur les restes des soldats de la Grande Armée de Napoléon (1812) ont révélé la présence entre autre de Rickettsia prowazekii. Pourtant la rickettsiologie ne commençera qu'avec les travaux de Ricketts et von Prowazek en 1910, et ne cessera de s'alimenter d'espèces et de pathologies nouvelles. En tant que premières bactéries intracellulaires strictes décrites, la taxonomie des rickettsies rassemblait initialement sur la base de ce critère, un grand nombre de genres bactériens ultérieurement reclassés avec l'avènement du séquençage et la découverte d'horloges moléculaires telle

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8

Simonin, Clémence. "De la stimulation cérébrale profonde à l’étude physiopathologique de certaines formes génétiques de la Maladie de Parkinson." Thesis, Lille 2, 2011. http://www.theses.fr/2011LIL2S032/document.

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Objectifs: D’une part étudier les effets de la SCP à moyen et long terme chez les patients de notre centre ayant une forme génétique de MP, d’autre part effectuer une étude clinique, génétique et transcriptomique d’un groupe de patients parkinsoniens ayant une mutation du gène SCA2 (dits patients SCA2).Méthode: 1/ Effet de la SCP chez des patients ayant une forme génétique de MP: cinq patients ayant une forme génétique de MP, appartenant à une cohorte de 52 patients parkinsoniens ayant bénéficié d’une stimulation à haute fréquence du noyau sous-thalamique entre 1998 et 2000, ont été examinés a

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9

Emmel, Vanessa Erichsen. "Análise de repetições CAG nos genes SCA1, SCA2, SCA3 e SCA6 em pacientes com suspeita clínica de ataxia espinocerebelar." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2007. http://hdl.handle.net/10183/10967.

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As ataxias espinocerebelares (SCAs) são doenças neurodegenerativas com herança autossômica dominante que apresentam grande heterogeneidade clínica e genética. O diagnóstico é realizado pela detecção da mutação no gene causador, que, na sua maioria, é uma expansão de repetições trinucleotídicas CAG. O objetivo deste estudo foi analisar os polimorfismos de repetições trinucleotídicas nos genes associados as SCAs tipo 1, tipo 2, tipo 3 e tipo 6 através de PCR-multiplex e eletroforese capilar, visando a melhoria do diagnóstico molecular e a determinação da distribuição das regiões polimórficas nos

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10

Åhlén, Johan. "Pilotstudie av FRIENDS : Ett preventionsprogram för ångestproblematik hos skolbarn." Thesis, Stockholm University, Department of Psychology, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-40651.

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<p>Ångestsyndrom tillhör den vanligaste psykiatriska problematiken hos barn. Ångestsyndrom börjar ofta i tidig ålder, medför stort lidande och predicerar psykiatrisk problematik senare i livet. Det är viktigt att undersöka hur ångestsyndrom kan förebyggas eftersom få barn med denna problematik kommer i kontakt med behandling. Syftet med studien var att undersöka om FRIENDS, ett preventionsprogram från Australien, fungerar i en svensk kontext. Femtio barn i nioårsåldern undervisades i FRIENDS under tio lektioner. Barnens ångestsymptom, depressionssymptom och generella psykiska hälsa mättes vid

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11

Hetrick, Shannon. "Examination of Driver Lane Change Behavior and the Potential Effectiveness of Warning Onset Rules for Lane Change or "Side" Crash Avoidance Systems." Thesis, Virginia Tech, 1997. http://hdl.handle.net/10919/36654.

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Lane change or "Side" Crash Avoidance Systems (SCAS) technologies are becoming available to help alleviate the lane change crash problem. They detect lane change crash hazards and warn the driver of the presence of such hazards. This thesis examines driver lane change behavior and evaluates the potential effectiveness of five warning onset rules for lane change or "side" crash avoidance system (SCAS) technologies. The ideal SCAS should warn the driver only when two conditions are met: (1) positive indication of lane change intent and (2) positive detection of a proximal vehicle in the adjac

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12

Zhu, Junqing. "Forensic Study and Finite Element Modeling of Unbonded Concrete Overlay Pavements on Interstate 70 & 77 in Ohio." Ohio University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1501156328255479.

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13

DeSousa, Diogo Araújo. "Instruments to assess anxiety symptoms in brazilian population and the case of the Spence Children's Anxiety Scale (SCAS) : cross-cultural adaptation and psychometric properties." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2013. http://hdl.handle.net/10183/79939.

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Esta dissertação é composta por quatro estudos acerca de instrumentos para a avaliação de sintomas de ansiedade. O objetivo do Estudo 1 foi realizar uma revisão sistemática dos instrumentos disponíveis para avaliar sintomas de ansiedade e transtornos de ansiedade (TA) em população brasileira. O objetivo do Estudo 2 foi realizar o processo de adaptação transcultural da Spence Children’s Anxiety Scale (SCAS) para o Brasil. O objetivo do Estudo 3 foi examinar a sensibilidade e especificidade da Screen for Child Anxiety Related Emotional Disorders (SCARED) para o diagnóstico de TA em uma amostra c

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14

Sundqvist, Linnéa, and Susanna Hillborg. "Hur kan företag med lågengagemangsprodukter gå tillväga för att uppnå emotionell och sann lojalitet gentemot kunderna? : En kvalitativ studie på SCAs produkter Edet papper och Libresse." Thesis, Södertörns högskola, Institutionen för ekonomi och företagande, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-16821.

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In a competitive market as supermarkets, hundreds of the same products fight for attention in the shops. Every day thousands of targeted advertising messages is given to us. As a natural result of all this, power is transferred to consumers. You can no longer differentiate yourself by only price and function, thus companies must play on the emotional aspects and create a relationship with consumers. A key to success is to understand people's emotional needs and then satisfying them. In various journals and papers you can find highlighted success stories of strong brands such as Harley-Davidson

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15

Socal, Mariana Peixoto. "Genes principais e genes predisponentes à doença de Parkinson : estudo sobre os genes PARK2, PARK6, PARK7, PARK8, SCA1, SCA2, SCA3, SCA6, SCA7 e o gene da glucocerebrosidase." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2008. http://hdl.handle.net/10183/16850.

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A doença de Parkinson é freqüente no mundo todo, atingindo indivíduos de todas as idades e etnias. Embora comum e muito estudada, seus mecanismos causais ainda não são plenamente conhecidos e ainda não há tratamento curativo. Atualmente, são conhecidos alguns fatores ambientais e genéticos associados ao desenvolvimento da doença de Parkinson. Dentre os fatores genéticos, foram identificados diversos genes que podem, ou determinar a ocorrência da doença de forma mendeliana (genes principais), ou apenas aumentar o risco de seu surgimento (genes de suscetibilidade). Embora os fatores genéticos, e

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16

Simonin, Clémence. "De la stimulation cérébrale profonde à l'étude physiopathologique de certaines formes génétiques de la Maladie de Parkinson." Phd thesis, Université du Droit et de la Santé - Lille II, 2011. http://tel.archives-ouvertes.fr/tel-00988248.

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Objectifs: D'une part étudier les effets de la SCP à moyen et long terme chez les patients de notre centre ayant une forme génétique de MP, d'autre part effectuer une étude clinique, génétique et transcriptomique d'un groupe de patients parkinsoniens ayant une mutation du gène SCA2 (dits patients SCA2).Méthode: 1/ Effet de la SCP chez des patients ayant une forme génétique de MP: cinq patients ayant une forme génétique de MP, appartenant à une cohorte de 52 patients parkinsoniens ayant bénéficié d'une stimulation à haute fréquence du noyau sous-thalamique entre 1998 et 2000, ont été examinés a

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17

Olivier, Andries J. "Effek van projektiewe narratiewe op kinders in kinderhuise se tekeninge van vrees." Thesis, Stellenbosch : Stellenbosch University, 2008. http://hdl.handle.net/10019.1/3047.

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Thesis (MEdPsych (Educational Psychology)--Stellenbosch University, 2008.<br>The study investigated the effect of using projective narratives and drawings that depict diminished fear, on the anxiety levels of a group of children living in children’s homes, by means of a mixed methodology. The sample consisted of 30 middle childhood children (mean age = 9.60 years, SD = 1.13) from three children’s homes in the Western Cape. Drawings were used to elicit content of fear or anxiety (anxiety evoking drawing/bangmaaktekening) and proposed coping (anxiety lessening drawing/bangwegvattekening). A

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18

Wei, Chen Feng, and 魏辰峯. "Functional Analyses of SCARB2– Interacting Protein." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/xbz2ve.

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19

Lin, Yi-Wen, and 林怡玟. "Establishment of human SCARB2 receptor transgenic mouse model for enterovirus 71 infection." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/69853725264084001643.

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博士<br>國立清華大學<br>分子醫學研究所<br>102<br>Enterovirus 71 (EV-71) is a caustic agent for hand, foot, and mouth disease (HFMD) in young children, but in some severe cases, neurological disorders with high mortality rates had been found. To date, epidemic outbreaks of EV71 have been reported mainly in Southeast and East Asia including Taiwan, Malaysia, Singapore, Japan, and China. The control of EV71 infection through public health interventions remains ineffectual and the treatments are unmet. Thus, study of the mechanisms of EV71 entry and it’s pathogenesis including HFMD and central nerve system (CNS)

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20

Chen, Hsiang-Ming, and 陳襄銘. "Spinocerebellar ataxias: Genetic testing of SCA2、SCA14 and interaction analysis between expanded SCA17 TBP and HMGB1." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/34332651521942248348.

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碩士<br>國立臺灣師範大學<br>生命科學研究所<br>95<br>Spinocerebellar ataxias (SCAs) are a group of neurodegenerative disorders characterized by cerebellar dysfunction alone or in combination with other neurological abnormalities. More than 28 SCA types have been described. Among them, SCA2 and SCA17 were caused by the expansions of coded CAG trinucleotide repeats and SCA14 cause by mutations in the protein kinase Cγ. We examined the CAG repeat range of SCA2 Ataxin-2 gene in 179 normal controls and in patients with various neurodegenerative diseases, including 15 ataxia, 137 Parkinson's disease, 124 dementia, 84

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21

Schröter, Roxane Henriette [Verfasser]. "Unterschiedliche Rollen des Adaptor-Proteins Blown-fuse-Skap-Hom-Scap2 und des Aktin-Regulators Kette-Hem2-Nap1 während der somatischen und viszeralen Myogenese von Drosophila melanogaster / vorgelegt von Roxane Henriette Schröter." 2006. http://d-nb.info/982218966/34.

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22

Cruzeiro, João Miguel da Conceição Alves do. "Development of a striatal lentiviral mouse model of Spinocerebellar ataxia type 2." Master's thesis, 2016. http://hdl.handle.net/10316/34085.

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Dissertação de Mestrado em Biologia Celular e Molecular apresentada à Faculdade de Ciências e Tecnologia da Universidade de Coimbra.<br>Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant ataxia caused by an expansion of ‘CAG’ repeats in the exon 1 of the gene ATXN2, conferring a gain of toxic function that triggers the appearance of the disease phenotype. The disease is characterized by several symptoms including progressive gait ataxia and dysarthria, slow saccadic eye movements, sleep disturbances, cognitive impairments and psychological dysfunctions such as insomnia and depressio

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23

Tomé, Sandra Marisa Oliveira. "Insights into the role of stress granules in spinocerebellar ataxias." Master's thesis, 2016. http://hdl.handle.net/10316/34187.

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24

Costa, Rafael Gomes da. "Insights into the spreading of ataxin-2 through extracellular vesicles." Master's thesis, 2021. http://hdl.handle.net/10400.1/17753.

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Spinocerebellar ataxia type 2 (SCA2) is a neurodegenerative polyglutamine disease caused by an aberrant expansion of the trinucleotide CAG in the coding region of the ATXN2 gene. As a result, ataxin-2, the protein product resulting from this gene, harbors an abnormally expanded polyglutamine tract, which renders it more prone to aggregation and consequent formation of inclusion bodies within the brain of SCA2 patients. Moreover, a toxic gain-of-function of ataxin-2, accompanied by the reported toxicity of an ATXN2 antisense RNA, are thought to induce cellular alterations with subsequent neuron

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25

Singh, Harpreet. "An Innovative Learning Management Approach for improving learning practices in Australian University Context." Thesis, 2021. https://vuir.vu.edu.au/43992/.

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With rapid expansion in knowledge streams over the last few years, the role of relevant education models and mechanisms have become increasingly important. Smarter Learning Management Systems (LMS) devised to enable student learnings at the university level have proven to be effective, yet the previous research points to the lack of employers’ perspective in the design of such systems. To bridge the existing gaps in the learning management systems, this study applied Design Science Research Methodology to design and develop an LMS artefact. This informed by the analysis of qualitative data col

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