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Dissertations / Theses on the topic 'SCD1'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

CAPUTO, MANUEL. "DEPDC1A, a novel SREBP1 cofactor, regulates fatty acid metabolism in breast cancer." Doctoral thesis, Università degli Studi di Trieste, 2018. http://hdl.handle.net/11368/2924764.

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Breast cancer (BC) figures as the most frequently diagnosed and the leading cause of cancer-related deaths among women worldwide. Despite considerable progress has been made in cancer detection and therapy assignment, several BCs become resistant to therapy and, moreover, a considerable proportion of patients develops metastasis during therapy or experiences relapse. Growing body of evidence indicates that alterations in tumour metabolism are linked to therapeutic resistance, tumour relapse and dissemination. These altered metabolic traits are caused by genetic alterations and environmental fa

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2

MacDonald, Marcia L. E., Eck Miranda van, Reeni B. Hildebrand, et al. "Despite antiatherogenic metabolic characteristics, SCD1-deficient mice have increased inflammation and atherosclerosis." American Heart Association, 2008. http://hdl.handle.net/2429/9434.

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OBJECTIVE—Absence of stearoyl-CoA desaturase-1 (SCD1) in mice reduces plasma triglycerides and provides protection from obesity and insulin resistance, which would be predicted to be associated with reduced susceptibility to atherosclerosis. The aim of this study was to determine the effect of SCD1 deficiency on atherosclerosis. Methods and RESULTS—Despite an antiatherogenic metabolic profile, SCD1 deficiency increases atherosclerosis in hyperlipidemic low density lipoprotein receptor (LDLR)-deficient mice challenged with a western diet. Lesion area at the aortic root is significantly increase

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Wehbi, Mariam. "Le récepteur du froid TRPM8 orchestre le métabolisme et la sécrétion des lipides par la régulation du SCD1 : implication de la physiologie de la prostate au syndrome métabolique et à l'insuffisance cardiaque." Electronic Thesis or Diss., Lyon 1, 2024. http://www.theses.fr/2024LYO10325.

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Le syndrome métabolique (MetS) représente une constellation d'anomalies interconnectées, dont l'obésité, la résistance à l'insuline, la dyslipidémie athérogène et l'hypertension. Tous ces facteurs augmentent le risque de maladies cardiovasculaires et de diabète de type 2. La dysrégulation du métabolisme lipidique et la perte de flexibilité métabolique jouent un rôle central dans la pathogenèse du MetS et de l'insuffisance cardiaque à fraction d'éjection préservée (HFpEF). La stéaroyl CoA désaturase 1 (SCD1), l'enzyme goulot d'étranglement qui convertit les acides gras saturés (AGS) en formes m

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4

Mattox, Cassie. "Examination of auxin transport and root development in the scd1-1 mutant in Arabidopsis thaliana." Winston-Salem, NC : Wake Forest University, 2009. http://dspace.zsr.wfu.edu/jspui/handle/10339/42592.

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5

Pinnameneni, Srijan Kumar, and s3083722@student rmit edu au. "Role of stearoyl-CoA desaturase1 in fatty acid-induced insulin resistance." RMIT University. Medical Sciences, 2006. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20070119.162450.

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Recent investigations suggest that reducing stearoyl CoA desaturase (SCD) 1 expression confers protection against obesity and insulin resistance, whereas others show that increasing SCD1 expression protects cells from lipotoxicity. The overall aim of this thesis was to establish the role of SCD1 expression in fatty acid metabolism and insulin stimulated glucose disposal in skeletal muscle. In vitro and in vivo studies were conducted to investigate the relationship between fatty acid subtype, SCD1 expression and fuel metabolism. The role of fatty acid subtype on fatty acid metabol

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Al, Darwich Abdulrahman. "Métabolisme lipidique et cryorésistance des embryons dans l’espèce bovine." Thesis, Tours, 2009. http://www.theses.fr/2009TOUR4031/document.

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Les embryons bovins produits in vitro sont plus sensibles à la cryoconservation que ceux produits in vivo, en partie à cause de leur contenu lipidique, triglycérides et phospholipides. L’objectif de ce travail visait à comprendre les mécanismes moléculaires responsables de cette différence. Le profil transcriptomique de gènes impliqués dans le métabolisme lipidique a été établi. Le niveau d'expression génique de l’adipophiline obtenu indique qu’il peut être un marqueur spécifique de l'accumulation des triglycérides et de la cryorésistance des embryons. Ainsi, l’accumulation des triglycérides p

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Hussain, Ghulam. "Rôle de la stéaroyl-CoA désaturase-1 dans le maintien de l'activité musculaire : étude d'un modèle lésionel pour la compréhension des altérations métaboliques caractéristiques de la sclérose latérale amyotrophique." Phd thesis, Université de Strasbourg, 2013. http://tel.archives-ouvertes.fr/tel-00921430.

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Les patients SLA et les souris modèles présentent un dysfonctionnement métabolique qui coïncide avec le changement de concentration de différentes espèces lipidiques. Notre hypothèse est qu'un tel dysfonctionnement métabolique au niveau musculaire conduirait aux premiers changements observés dans la SLA. Nous avons montré que l'expression de la stéaroyl-coenzyme A désaturase 1 (SCD1), une enzyme clé de la synthèse des acides gras mono-insaturés à partir des acides gras saturés, est diminuée dans le muscle avant les premiers symptômes moteurs observés chez les souris modèles de SLA. Dans ce mod

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8

Kgwatalala, Patrick M. 1973. "Genetic polymorphisms in the stearoyl-CoA desaturase1 (SCD1) gene and their influence on the conjugated linoleic acid (CLA) and monounsaturated fatty acids (MUFA) content of milk fat of Canadian Holstein and Jersey cows." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=115690.

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Stearoyl-CoA desaturase1 (SCD1) catalyzes the synthesis of conjugated linoleic acid (CLA) and mono-unsaturated fatty acids (MUFA) in the mammary gland of ruminant animals. We hypothesized that single nucleotide polymorphisms (SNPs) in the coding region, 5' and 3' untranslted regions (UTRs) of the SCD1 gene would influence the activity of SCD1 enzyme and consequently account for some within-breed variations in milk CLA and MUFA. Sequence analysis of the coding region of the SCD1 gene of Jerseys and Holsteins revealed c.702A→G, c.762T→C and c.878C→T SNPs in exon 5 in both breeds a

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Schmitt, Florent. "Rôle de la stéaroyl-coenzyme A désaturase 1, une enzyme de synthèse des acides gras mono-insaturés, dans un modèle transgénique d’étude de la Sclérose Latérale Amyotrophique." Thesis, Strasbourg, 2013. http://www.theses.fr/2013STRAJ085/document.

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La sclérose latérale amyotrophique est une maladie neurodégénérative associée à un dysfonctionnement métabolique. Des altérations du métabolisme des lipides, décrites chez les patients SLA et les animaux modèles, pourraient participer à la mise en place des premières étapes de la maladie. L’objectif de cette thèse était d’étudier le rôle de la stéaroyl-coenzyme A désaturase 1 (SCD1), une enzyme clé du métabolisme des lipides, dans la SLA. En étudiant le profil d’acides gras périphériques dans un modèle de souris SLA, les souris SOD1m, nous avons vu une diminution de l’activité de la SCD1 dès l

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10

Warensjö, Eva. "Fatty Acid Desaturase Activities in Metabolic Syndrome and Cardiovascular Disease : Special Reference to Stearoyl-CoA-Desaturase and Biomarkers of Dietary Fat." Doctoral thesis, Uppsala University, Clinical Nutrition and Metabolism, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8312.

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<p>The development of the metabolic syndrome (MetS) and cardiovascular diseases have been suggested to be influenced more by the quality than the amount of dietary fat. The FA composition of serum lipids may be used as biomarkers of dietary fat quality. FAs can, however, also be endogenously synthesized by lipogenic enzymes such as elongases and desaturases. Three desaturases are important in humans: Stearoyl-CoA-desaturase (SCD), ∆6-desaturase (D6D) and ∆5-desaturase (D5D) and surrogate measures of desaturase activities can be estimated as product-to-precursor FA ratios.</p><p>In this thesis,

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Cassafières, Cécile Dalhoumi Salah Fèvre Véronique Jove Camille Lefebvre Pascale Loiselet Martine Elaïdi Claudine. "Formation et évaluation en SCD." [S.l.] : [s.n.], 2005. http://www.enssib.fr/bibliotheque/documents/dcb/M-2005-RECH-02-vol1.pdf.

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Medeiros, Ana Carla. "Caracterização parcial do complexo SCF1 contendo a proteína FBXO25 fosforilada." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/17/17131/tde-09092015-110529/.

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A FBXO25 é parte de uma E3 ligase do tipo RING, (Really Interesting New Gene), oligomérica do tipo SCF, responsável pelo reconhecimento específico do substrato a ser degradado via Sistema Ubiquitina-Proteassoma (SUP). O SUP é o principal mecanismo proteolítico intracelular, responsável pela degradação de 80-90% das proteínas citosólicas e nucleares. A FBXO25 é capaz de formar um complexo SCF1 ativo (formado pela interação das proteínas Skp1, Cul1, Roc1 e uma proteína do tipo F-box), capaz de ubiquitinar seus substratos. Essa proteína se acumula no núcleo celular formando uma nova estrutura sub

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Dempsey, Kate E. "Characterisation of a human stearoyl CoA desaturase gene (SCD2)." Thesis, Glasgow Caledonian University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369995.

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Bleiziffer, Oliver. "Die Effekte des Komplementinhibitors sCR1 auf die Mikrozirkulation des Pankreas." Diss., lmu, 2004. http://nbn-resolving.de/urn:nbn:de:bvb:19-29914.

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Caswell, Clayton Christopher. "The SCL1 protein of Streptococcus pyogenes a structure-function analysis /." Morgantown, W. Va. : [West Virginia University Libraries], 2008. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=6026.

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Thesis (Ph. D.)--West Virginia University, 2008.<br>Title from document title page. Document formatted into pages; contains xi, 190 p. : ill. (some col.). Includes abstract. Includes bibliographical references.

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Cruz, Castillo Manuel Eduardo. "Informe sobre Expediente N° 0622-2010/SC1." Bachelor's thesis, Pontificia Universidad Católica del Perú, 2021. http://hdl.handle.net/20.500.12404/19767.

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Considero que el presente expediente tiene especial relevancia debido a que recientemente se ha aprobado la Ley N° 31112, el cual establece el control previo de operaciones de concentración empresarial; y mediante la cual se derogó la Ley 26876 – Ley Antimonopolio y Antioligopolio del Sector Eléctrico. De esta manera, mi elección del presente expediente se encuentra justificada en el hecho de que, una vez que entre en vigencia la Ley antes mencionada, se necesitará de profesionales que cuenten con conocimiento tanto del lado corporativo de una fusión y adquisición, así como del lado regu

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Lundö, Emma, and Sara Norrman. "Ett förslag på hur föräldraskattningsinstrumentet SCDI-III kan valideras : en pilotstudie." Thesis, Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-176308.

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I denna studie ett förslag till validering av föräldraskattningsformuläret SCDI-III baserad på en genomförd pilotstudie. Studiens syfte är att undersöka hur väl föräldrars och förskolepedagogers skattning av deltagande barns språkförmåga med skattningsinstrumentet SCDI-III överensstämmer med resultaten av ett test som studieförfattarna utformade. Testmaterialet speglar direkt de frågor som ställs till vårdnadshavarna och förskolepedagoger i SCDI-III. Tio barn i åldersgruppen 2;5–3;10 år med svenska som starkaste språk, tio vårdnadshavare och tio förskolepedagoger deltog i studien. Studieförf

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Gaillard, Béatrice Duchemin Pierre-Yves. "Organiser la gestion des ressources électroniques dans un SCD de Sciences Humaines et Sociales le cas du SCD de Lyon 2 /." [S.l.] : [s.n.], 2005. http://www.enssib.fr/bibliotheque/documents/dcb/gaillard.pdf.

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Tang, Matthew Y. "Gene reprogramming by K48R mutant ubiquitin in a mouse model of SCA1." Thesis, University of Ottawa (Canada), 2005. http://hdl.handle.net/10393/27054.

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Spinocerebellar ataxia type 1 (SCA1) is an incurable neurodegenerative disease resulting from the loss of Purkinje neurons within the cerebellum. The causative agent of the disease is the expansion of a trinucleotide repeat in its gene product ataxin-1. The ubiquitin proteasome pathway (UPP) has been implicated in SCA1 but the role of proteolysis in the disease is still poorly understood. To further investigate this issue in vivo , genetic crosses were performed between a well established mouse model of SCA1 and novel strains expressing elevated levels of wild type or mutant isoforms of ubiqui

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Odeskog, Sanna, and Noomi Stenberg. "Validering av föräldraskattningsformuläret SCDI-III för svenska barn i tre års ålder." Thesis, Linköpings universitet, Institutionen för klinisk och experimentell medicin, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-118710.

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Föräldraskattningsformuläret The Swedish Communicative Development Inventory (SCDI-III) är en modifierad form av MacArthur-Bates Communicative Development Inventorys tredje form (CDI-III), och har tagits fram som ett forskningsinstrument för undersökning av språkförmågan hos barn i åldersgruppen 2;6-4;0 år. Det är av stor betydelse att barn i riskzonen för att utveckla en språkstörning upptäcks i tid för att språket ska kunna stimuleras under gynnsamma utvecklingsfaser. Kliniskt verksamma personer har givit uttryck för ett behov av ett material som kan ge en överblick av ett barns språkförmåga

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Chung, Ki Yong. "Metabolic and genetic regulation in adipose tissue of Angus and Wagyu steers raised to U.S. and Japanese endpoints." Diss., Texas A&M University, 2003. http://hdl.handle.net/1969.1/3909.

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We hypothesized that carcass and fatty acid composition of Angus and Japanese Black (Wagyu) steers would not differ if the steers were fed to a typical U.S. final weight, but that Wagyu steers fed to a typical Japanese endpoint body weight would have greater quality grades and softer fat than Angus steers. Sixteen Angus and 16 Wagyu 8-month-old, weaned steers were assigned to a corn-based diet for 8 or 16 months (n = 4 per breed type and time) or hay-based diet for 12 or 20 months (n = 4 per breed type and time) in a 2 x 2 x 2 factorial arrangement. USDA yield grade was greater at the Japanese

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De, la Flor Giuffra Arantxa. "Informe Jurídico sobre la Resolución 0761-2011-SC1-INDECOPI." Bachelor's thesis, Pontificia Universidad Católica del Perú, 2021. http://hdl.handle.net/20.500.12404/19958.

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En el presente informe se realiza un análisis jurídico de los argumentos y la decisión adoptada por el Tribunal de Defensa de la Competencia y de la Propiedad Intelectual en la Resolución 0761-2011/SC1-INDECOPI, correspondiente a la denuncia interpuesta por el Estudio para la Defensa de los Derechos de la Mujer - DEMUS en contra de la Compañía Cervecera Ambev Perú S.A.C y Grupo Q Comunicaciones S.A., a raíz de la difusión del anuncio publicitario “Con B de Brahma”. Este trabajo estudia el alcance y aplicación del principio de legalidad y el principio de adecuación social, contenidos en la Ley

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Bruley, Caroline. "La section Sciences du SCD de Nice - Sophia Antipolis." [S.l.] : [s.n.], 2003. http://www.enssib.fr/bibliotheque/documents/dcb/rsbruley.pdf.

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Rohr, Ute. "sCD14, TNFa a,Interleukin-6, sICAM-1 und sE-Selektin im septischen Geschehen." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 1998. http://dx.doi.org/10.18452/14416.

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In einer prospektiven Studie wurden bei 28 kritisch kranken Patienten einer interdisziplinären Intensivstation die Plasmaspiegel von TNF[alpha], sCD14, Interleukin-6 (IL-6), sICAM-1 und sE-Selektin gemessen. Ziel der Studie war es, die genannten Parameter in ihrer Wertigkeit als Frühparameter der Sepsis zu untersuchen. Die Plasmaspiegel der Parameter TNF[alpha], IL-6, sCD14, sICAM-1 und sE-Selektin wurden mittels ELISA-Testkits bestimmt. Insgesamt wurde in einem Zeitraum von 11 Beobachtungstagen täglich 10 ml Blut entnommen, zentrifugiert und bis zur Verarbeitung tiefgefroren. Gruppe 1

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Chung, Ki Yong. "Metabolic regulation of cattle adiposity in different breed types using two disparate diets." Thesis, Texas A&M University, 2004. http://hdl.handle.net/1969.1/1092.

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Fifteen steers were used to evaluate the difference of diets (corn-based for 8 mo or hay-based for 12 mo) and breeds (Angus; n = 7 or Wagyu; n = 8) in a completely randomized design with 2 x 2 factorial arrangement of treatments to test the hypothesis that there are differences in fatty acid metabolism and cellularity in subcutaneous (s.c.) and intramuscular (i.m.) adipose tissue between these breeds types. Fat thickness, carcass weight, overall maturity, and yield grade of Angus steers were higher than those of Wagyu steers fed either corn (34%, 22%, 3%, and 8% higher, respectively) or hay di

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Krljes, S. "English validation study of the Schizophrenia Communication Disorder Scale (SCD)." Thesis, University College London (University of London), 2010. http://discovery.ucl.ac.uk/850098/.

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Language defects are one of the nuclear features of schizophrenia, and difficulties in semantic memory processing have been considered to be at the core of these deficits. However, the underlying mechanisms of deficits in semantic memory processing and their relationship to the overt symptoms of schizophrenia are still not entirely understood. Furthermore, tools for assessing language deficits in schizophrenia are sparse and the existing ones are based on observations rather than a pathophysiological understanding of these deficits. The first part of this thesis is a literature review aiming t

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Even, Virginie Roux-Fouillet Jean-Paul. "La valorisation des périodiques électroniques au SCD de Bretagne occidentale." [S.l.] : [s.n.], 2004. http://www.enssib.fr/bibliotheque/documents/ppp/pppeven.pdf.

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Goodman, Anya L. 1973. "The S. cerevisiae calponin homologue SCP1 regulates stability and organization of the actin cytoskeleton." Thesis, Massachusetts Institute of Technology, 2003. http://hdl.handle.net/1721.1/29594.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2003.<br>Includes bibliographical references (p. 149-164).<br>Calponins and transgelins are members of a conserved family of actin-associated proteins widely expressed from yeast to humans. While a role for calponin in muscle cells has been described, the biochemical activities and in vivo functions of non-muscle calponins and transgelins are largely unknown. I have used genetic and biochemical analyses to characterize the budding yeast member of this family, Scpl, which most closely resembles transgelin and contains one

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Tso, Cynthia K. W. "A reassessment of the interaction between complement C3d and complement receptor CD21 SCR1-2." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:29114281-a320-459d-88a6-9b5fad7c3f7f.

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Biophysical characterisation of protein – ligand interactions can provide vital information to dissect complex biochemical binding mechanisms. C3d has been shown to interact with a number of different protein ligands, namely CD21 SCR1-2, S. aureus Efb-C, S. aureus Ehp, S. aureus Sbi and complement regulatory protein factor H. Although much is known about the relationship of C3d and CD21 in the induction of humoral immunity, the structural aspects of this interaction remained controversial until very recently. The aim of this thesis was to gain a detailed understanding of the C3d/CD21 SCR1-2 in

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Planade, Jessica. "Etude du rôle des protéines partenaires de l'actine dans la mécanique des gels branchés de levure." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC285/document.

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Par ce travail expérimental, nous essayons d’établir un lien entre les propriétés mécaniques de gels d’actine branchés de levure et la composition biochimique des réseaux. L’actine est un polymère semi-flexible qui fait partie du cytosquelette. De nombreux partenaires protéiques de l’actine (notés ABPs par la suite) se lient aux filaments d’actine et les agencent en différents types de réseaux. Arp2/3 est un complexe protéique qui génère la croissance de réseaux d’actine branchés. Les réseaux d’actine branchés en croissance intéressent tout particulièrement physiciens comme biologistes car ils

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Bertolino, Lígia Tereza. "Estudo das Proteínas 14-3-3A e 14-3-3D de Nicotiana tabacum L. e seu Papel no Desenvolvimento Floral." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/17/17135/tde-21052014-113419/.

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A modulação da forma e tamanho em órgãos vegetais depende do controle temporal e espacial de divisão e expansão celular. Entretanto, pouco se sabe a respeito dos mecanismos moleculares que regulam este processo durante o desenvolvimento floral. O estudo da via de sinalização de SCI1 (Stigma/style Cell Cycle Inhibitor 1) pode contribuir para o entendimento do processo de crescimento das flores. Este gene produz uma proteína, localizada no nucléolo, que está relacionada à inibição da proliferação celular no estigma e no estilete de Nicotiana tabacum, modulando o tamanho destes órgãos florais. Ex

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Melo, Jussara Costa. "Estudo empírico sobre a proposta do serviço de comunicações digitais - SCD." reponame:Repositório Institucional da UnB, 2012. http://repositorio.unb.br/handle/10482/11414.

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Orientação: Carlos Eduardo Machado da Costa Esch.<br>Dissertação (mestrado)—Universidade de Brasília, Faculdade de Comunicação, Programa de Pós-Graduação em Comunicação, 2012.<br>Submitted by Alaíde Gonçalves dos Santos (alaide@unb.br) on 2012-10-08T11:46:44Z No. of bitstreams: 1 2012_ThiagodeAzevedoBarbosa.pdf: 1076277 bytes, checksum: d71ec19813d334266e2ba00d6c96c4bf (MD5)<br>Rejected by Guimaraes Jacqueline(jacqueline.guimaraes@bce.unb.br), reason: Alaíde, O arquivo carregado é de outro autor. Por favor, efetuar a troca. Obrigada! Jacqueline on 2012-10-11T14:34:24Z (GMT)<br>Submitted b

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Beurton, Ginette Ducharme Christian. "Extension de l'intranet documentaire du SCD de l'Université d'Evry-Val-d'Essonne." [S.l.] : [s.n.], 2002. http://www.enssib.fr/bibliotheque/documents/ppp/ppp-beurton.pdf.

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Lubini, Greice. "NtCDKG;2, uma proteína multifuncional, relacionada aos processos de transcrição, processamento de RNA e organização do fuso acromático no ciclo celular de Nicotiana tabacum." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17135/tde-06062017-171202/.

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Os estudos em reprodução e desenvolvimento das plantas, especialmente voltados ao pistilo, são de grande interesse agronômico, econômico e científico. Em nosso laboratório, recentemente, foi identificado e caracterizado SCI1 (Stigma/style Cell-cycle Inhibitor 1), um inibidor do ciclo celular que atua de forma tecido específica no pistilo de Nicotiana tabacum L. e Arabidopsis thaliana (L.) Heynh. (DEPAOLI et al., 2011; DEPAOLI; DORNELAS; GOLDMAN, 2014). Foi identificada a proteína NtCDKG;2 (N. tabacum Cyclin-dependent Kinase 2) como parceira de interação de NtSCI1 (N . tabacum SCI1), em um ensa

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Rohr, Ute. "SCD14, TNF[alpha] [TNF alpha], Interleukin-6, sICAM-1 und sE-Selektin im septischen Geschehen." [S.l. : s.n.], 1998. http://deposit.ddb.de/cgi-bin/dokserv?idn=956128815.

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De, Gaspari Piera [Verfasser]. "Lineage tracing of Sca1-expressing cells in the heart and skeletal muscle / Piera De Gaspari." Gießen : Universitätsbibliothek, 2015. http://d-nb.info/1075454514/34.

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Keiser, Megan Kathryn. "Gene therapies for spinocerebellar ataxia type 1." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/2540.

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Spinocerebellar ataxia type 1 (SCA1) is an adult onset, autosomal dominant neurodegenerative disease caused by a CAG repeat expansion in ataxin-1, which encodes the ataxin-1 protein. SCA1 is one of nine polyQ-expansion gain-of-function diseases which includes Huntington's disease, spinal-bulbar muscular atrophy, dentatorubral-pallidoluysian atrophy and other ataxias. Clinical symptoms of SCA1 include ataxia, dysarthria, ophthalmoparesis, muscle wasting, and extrapyramidal and bulbar dysfunction. Cerebellar Purkinje cells (

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Sorice, Andréia Fátima. "Análise da evolução de longo prazo das temperaturas do satélite SCD-1." Instituto Tecnológico de Aeronáutica, 2007. http://www.bd.bibl.ita.br/tde_busca/arquivo.php?codArquivo=389.

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O objetivo desta dissertação de mestrado é investigar as causas da elevação da temperatura do satélite SCD-1 (Satélite de Coleta de Dados) ao longo dos seus 13 anos em órbita. O SCD-1 é o primeiro satélite projetado e construído no Brasil, lançado com sucesso em 1993, e ainda em operação. O controle térmico foi realizado por meio passivo usando tintas, isolantes térmicos e materiais condutivos, apropriados para manter as temperaturas do satélite em níveis especificados. Um modelo matemático foi desenvolvido para simular o comportamento térmico do SCD-1 em órbita, sendo utilizado como ferrament

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Caron, Valérie. "Formation et autoformation des usagers au SCD de l'Université de la Réunion." [S.l.] : [s.n.], 2002. http://www.enssib.fr/bibliotheque/documents/dcb/rscaron.pdf.

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Lobet, Jean-Luc Chartron Ghislaine. "Evaluer l'utilisation de la collection électronique l'exemple du SCD de Lyon 2 /." [S.l.] : [s.n.], 2004. http://www.enssib.fr/bibliotheque/documents/dcb/lobet.pdf.

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Orain, Christine Collinot Anne. "LMD et politique documentaire exemple du SCD de l'Université de Rennes 2 /." [S.l.] : [s.n.], 2004. http://www.enssib.fr/bibliotheque/documents/dcb/orain.pdf.

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Smouts, Marie. "La communication interne en bibliothèque l'exemple du SCD de l'Université Lyon I /." [S.l.] : [s.n.], 2003. http://www.enssib.fr/bibliotheque/documents/dcb/smouts.pdf.

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Silva, Fabiana Brandão Alves. "Análise da expressão gênica da proteína homóloga à Scc1/Rad21 do complexo Coesina em Trypanosoma cruzi." reponame:Repositório Institucional da UnB, 2012. http://repositorio.unb.br/handle/10482/10953.

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Dissertação (mestrado)—Universidade de Brasília, Instituto de Ciências Biológicas, Departamento de Biologia Celular, 2012.<br>Submitted by Jaqueline Ferreira de Souza (jaquefs.braz@gmail.com) on 2012-07-17T10:18:34Z No. of bitstreams: 1 2012_FabiansBrandaoAlvesSilva.pdf: 3339585 bytes, checksum: 3a2b291213f89307c5254e99ccac67ea (MD5)<br>Approved for entry into archive by Jaqueline Ferreira de Souza(jaquefs.braz@gmail.com) on 2012-07-17T10:18:49Z (GMT) No. of bitstreams: 1 2012_FabiansBrandaoAlvesSilva.pdf: 3339585 bytes, checksum: 3a2b291213f89307c5254e99ccac67ea (MD5)<br>Made available in DSp

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Gronychová, Gabriela. "Globální talent management ve společnosti Schindler." Master's thesis, Vysoká škola ekonomická v Praze, 2015. http://www.nusl.cz/ntk/nusl-201730.

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The Master thesis Global talent management in Schindler Company aims to map the concept of the career programme in Schindler Company SCDP (Schindler Career Development Programme) and to assess the feedback of programme participants based on the survey among participants. The thesis is divided into three parts. The first part of the thesis consists of theoretical knowledge on talent management and work with talents. Basic and key terms that are crucial for deeper introduction to the topic are defined in this part as well. The second part already has a practical character and it is dedicated to

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Lampin, Philippe. "Préparation, étude structurale en relation avec la transition de phase des oxydes ferroélectriques de type pérovskite : Pb(Sc1/2Ta1/2)O3,Pb(Sc1/2Nb1/2)O3 et leur solution solide." Aix-Marseille 3, 1994. http://www.theses.fr/1994AIX30012.

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NOUS AVONS ETUDIE LA RELATION ENTRE NANOSTRUCTURE ET TRANSITION DE PHASE FERRO-PARAELECTRIQUE, POUR LES MATERIAUX PbSc1/2Ta1/2O3(PST), PbSc1/2O3(PSN) ET LEUR SOLUTION SOLIDE (PSNT). DES IONS DIFFERENTS (SC,TA ET/OU NB) SUR LE SITE B DE LA STRUCTURE PEROVSKITE SONT A L'ORIGINE DE L'APPARITION DE SURSTRUCTURES DONT L'IMPORTANCE REND LA TRANSITION PLUS OU MOINS DIFFUSE. DES MONOCRISTAUX ONT ETE SYNTHETISES AFIN DE POUVOIR TRAVAILLER SUR DES PHASES PURES. ILS PRESENTENT PAR DIFFRACTION DES RAYONS-X A TEMPERATURE AMBIANTE UNE STRUCTURE MOYENNE CUBIQUE, MEME SI POUR PSN LES MESURES SONT EFFECTUEES E

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Pierre, Andrew F. "The effect of complement inhibition with soluble complement receptor 1 (sCR1) on pig allo-transplant lung function." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ29290.pdf.

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Chang, Ya-Ju [Verfasser], Matthias [Akademischer Betreuer] Finkbeiner, Matthias [Gutachter] Finkbeiner, and Marzia [Gutachter] Traverso. "The Sustainable Child Development Index (SCDI) / Ya-Ju Chang ; Gutachter: Matthias Finkbeiner, Marzia Traverso ; Betreuer: Matthias Finkbeiner." Berlin : Technische Universität Berlin, 2018. http://d-nb.info/1168324149/34.

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Carpio, Ricardo, Juan Zapata, Eberhard Spanuth, and Georg Hess. "Utility of presepsin (sCD14-ST) as a diagnostic and prognostic marker of sepsis in the emergency department." Elsevier B.V, 2015. http://hdl.handle.net/10757/576944.

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Presepsin (PSEP) is released during infectious diseases and can be detected in the blood. PSEP has shown promising results as sepsis marker. We examined the diagnostic and prognostic validity of PSEP in patients suspicious of sepsis on admission in the emergency department (ED). Methods One hundred twenty three patients with signs of SIRS and/or sepsis and 123 healthy individuals were enrolled. PSEP was determined on admission, after 8, 24 and 72 h. Results Mean PSEP concentrations of the control group and the patient group were 130 and 1945 pg/ml. PSEP differed between SIRS, sepsis, severe se

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Ngwamidiba, Maxime. "Etude moléculaire des gènes SCA1 et SCA2 codant des protéines autotransporteurs chez les membres du genre " rickettsia"." Aix-Marseille 2, 2006. http://www.theses.fr/2006AIX20660.

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Des analyses d'ADN sur les restes des soldats de la Grande Armée de Napoléon (1812) ont révélé la présence entre autre de Rickettsia prowazekii. Pourtant la rickettsiologie ne commençera qu'avec les travaux de Ricketts et von Prowazek en 1910, et ne cessera de s'alimenter d'espèces et de pathologies nouvelles. En tant que premières bactéries intracellulaires strictes décrites, la taxonomie des rickettsies rassemblait initialement sur la base de ce critère, un grand nombre de genres bactériens ultérieurement reclassés avec l'avènement du séquençage et la découverte d'horloges moléculaires telle

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Tiittanen, Anni, Camilla Orre, and Maryana Isaac. "En prövning av föräldraskattningsformuläret SCDI-III på somaliska : Svårigheter med att översätta frågeformulär till ett nytt språk." Thesis, Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-168139.

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Under de senaste trettio åren, har antalet flerspråkiga individer ökat i Sverige betydligt. Antalet flerspråkiga barn i behov av en noggrann språklig undersökning är därmed stort. Det råder dessutom en generell brist på språkliga bedömningsmaterial för flerspråkiga barn i Sverige. Somalier utgör en stor del av den flerspråkiga gruppen i Sverige, vilket motiverar behovet av ett språkligt instrument för denna population. En översättning till somaliska av föräldraskattningsformuläret The Swedish Communicative Development Inventory (SCDI-III) har därför skapats. SCDI-III är en anpassning av MacArt

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