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Journal articles on the topic 'SCD89'

Author: Grafiati

Published: 22 June 2024

Last updated: 31 July 2025

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1

Berthelot, Laureline, Christina Papista, Thiago T. Maciel, et al. "Transglutaminase is essential for IgA nephropathy development acting through IgA receptors." Journal of Experimental Medicine 209, no. 4 (2012): 793–806. http://dx.doi.org/10.1084/jem.20112005.

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IgA nephropathy (IgAN) is a common cause of renal failure worldwide. Treatment is limited because of a complex pathogenesis, including unknown factors favoring IgA1 deposition in the glomerular mesangium. IgA receptor abnormalities are implicated, including circulating IgA–soluble CD89 (sCD89) complexes and overexpression of the mesangial IgA1 receptor, TfR1 (transferrin receptor 1). Herein, we show that although mice expressing both human IgA1 and CD89 displayed circulating and mesangial deposits of IgA1–sCD89 complexes resulting in kidney inflammation, hematuria, and proteinuria, mice expres

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Wu, Haiting, Xiaoyan Wang, Zhe Yang, et al. "Serum Soluble CD89-IgA Complexes Are Elevated in IgA Nephropathy without Immunosuppressant History." Disease Markers 2020 (January 16, 2020): 1–6. http://dx.doi.org/10.1155/2020/8393075.

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Purpose. CD89 (FcαRI), the receptor of IgA, can shed from cells to form complexes with IgA in serum and is supposed to participate in the pathogenesis of IgA nephropathy (IgAN). There are contradictory results on their utility in clinical practice. This study is aimed at investigating whether sCD89-IgA complexes can help in the diagnosis or evaluation of the disease. Methods. A sandwich ELISA was established using anti-CD89 as a capture antibody and HRP-conjugated anti-IgA as a detection antibody. This method was used to measure serum levels of sCD89-IgA complexes in IgAN patients without immu

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van Zandbergen, Ger, Ralf Westerhuis, Ngaisah Klar Mohamad, Jan G. J. van de Winkel, Mohamed R. Daha та Cees van Kooten. "Crosslinking of the Human Fc Receptor for IgA (FcαRI/CD89) Triggers FcR γ-Chain-Dependent Shedding of Soluble CD89". Journal of Immunology 163, № 11 (1999): 5806–12. http://dx.doi.org/10.4049/jimmunol.163.11.5806.

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Abstract CD89/FcαRI is a 55- to 75-kDa type I receptor glycoprotein, expressed on myeloid cells, with important immune effector functions. At present, no information is available on the existence of soluble forms of this receptor. We developed an ELISA for the detection of soluble CD89 (sCD89) forms and investigated the regulation of sCD89 production. PMA/ionomycin stimulation of monocytic cell lines (U937, THP-1, and MM6), but not of neutrophils, resulted in release of sCD89. Crosslinking of CD89 either via its ligand IgA or with anti-CD89 mAbs similarly resulted in sCD89 release. Using CD89-

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Di Leo, Vincenzo, Patrick J. Gleeson, Fabio Sallustio, et al. "Rifaximin as a Potential Treatment for IgA Nephropathy in a Humanized Mice Model." Journal of Personalized Medicine 11, no. 4 (2021): 309. http://dx.doi.org/10.3390/jpm11040309.

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IgA Nephropathy (IgAN) is the most common glomerulonephritis worldwide, characterized by the mesangial deposition of abnormally glycosylated IgA1 (Gd-IgA). The production of Gd-IgA occurs in mucose-associated lymphoid tissue (MALT). The microbiota plays a role in MALT modulation. Rifaximin (NORMIX®), a non-absorbable oral antibiotic, induces positive modulation of the gut microbiota, favoring the growth of bacteria beneficial to the host. Here, we evaluate the effect of rifaximin on a humanized mice model of IgAN (α1KI-CD89Tg). Methods: The α1KI-CD89Tg mice were treated by the vehicle (olive o

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Esteve Cols, Clara, Freddzia-Amanda Graterol Torres, Bibiana Quirant Sánchez, et al. "Immunological Pattern in IgA Nephropathy." International Journal of Molecular Sciences 21, no. 4 (2020): 1389. http://dx.doi.org/10.3390/ijms21041389.

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The current gold-standard diagnostic technique for IgA nephropathy (IgAN), the leading form of primary glomerulonephritis, is renal biopsy. CD89 (the main IgA receptor) is expressed on the surface of monocytes and plays a role in disease pathogenesis. Immunocomplexes formed by sCD89 (soluble form) and Gd-IgA1 are related to disease prognosis. We hypothesize that reduced CD89 surface expression on monocytes may be a marker of disease severity. We aimed to analyze leukocyte subpopulations in peripheral blood and CD89 surface expression on monocytes in a prospective study of 22 patients and 12 he

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Zych, Michał, Aleksander Roszczyk, Filip Dąbrowski, Monika Kniotek, and Radosław Zagożdżon. "Soluble Forms of Immune Checkpoints and Their Ligands as Potential Biomarkers in the Diagnosis of Recurrent Pregnancy Loss—A Preliminary Study." International Journal of Molecular Sciences 25, no. 1 (2023): 499. http://dx.doi.org/10.3390/ijms25010499.

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Immune checkpoints (ICPs) serve as regulatory switches on immune-competent cells. Soluble ICPs consist of fragments derived from ICP molecules typically located on cell membranes. Research has demonstrated that they perform similar functions to their membrane-bound counterparts but are directly present in the bloodstream. Effective control of the maternal immune system is vital for a successful pregnancy due to genetic differences between the mother and fetus. Abnormalities in the immune response are widely acknowledged as the primary cause of spontaneous abortions. In our research, we introdu

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Liu, Chao, Xiaohui Li, Aijie Li, et al. "Concurrent Chemoradiotherapy Increases the Levels of Soluble Immune Checkpoint Proteins in Patients with Locally Advanced Cervical Cancer." Journal of Immunology Research 2022 (April 4, 2022): 1–8. http://dx.doi.org/10.1155/2022/9621466.

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Purpose. Concurrent chemoradiotherapy (CCRT) has been widely applied to locally advanced cervical cancer (LACC) patients, inducing the massive release of antigen and systematic immunomodulatory effects. However, its effect on the soluble immune checkpoint proteins (sICPs) remains unclear, which might play a key role in the immune response. Therefore, the current study explored changes in the levels of 16 sICPs in LACC patients during CCRT. Methods. We prospectively enrolled fifty-one LACC patients treated with CCRT and collected patients’ blood before, during and after CCRT. The levels of 16 s

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Odagiri, Naoshi, Hoang Hai, Le Thi Thanh Thuy, et al. "Early Change in the Plasma Levels of Circulating Soluble Immune Checkpoint Proteins in Patients with Unresectable Hepatocellular Carcinoma Treated by Lenvatinib or Transcatheter Arterial Chemoembolization." Cancers 12, no. 8 (2020): 2045. http://dx.doi.org/10.3390/cancers12082045.

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Immune checkpoint inhibitors, combined with anti-angiogenic agents or locoregional treatments (e.g., transarterial chemoembolization (TACE)), are expected to become standard-of-care for unresectable hepatocellular carcinoma (HCC). We measured the plasma levels of 16 soluble checkpoint proteins using multiplexed fluorescent bead-based immunoassays in patients with HCC who underwent lenvatinib (n = 24) or TACE (n = 22) treatment. In lenvatinib-treated patients, plasma levels of sCD27 (soluble cluster of differentiation 27) decreased (p = 0.040) and levels of sCD40 (p = 0.014) and sTIM-3 (p <

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KAKOULIDOU, M., X. WANG, X. ZHAO, R. PIRSKANEN, and A. LEFVERT. "Soluble costimulatory factors sCD28, sCD80, sCD86 and sCD152 in relation to other markers of immune activation in patients with myasthenia gravis." Journal of Neuroimmunology 185, no. 1-2 (2007): 150–61. http://dx.doi.org/10.1016/j.jneuroim.2007.01.007.

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10

Lin, Wei. "sCD83 alleviates experimental autoimmune uveitis through disrupting the regulation of Rab1a/LRRK2 on F-actin rearrangements." Journal of Immunology 202, no. 1_Supplement (2019): 116.2. http://dx.doi.org/10.4049/jimmunol.202.supp.116.2.

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Abstract A soluble form of CD83, generated from membrane CD83 by splice variants or by shedding, inhibites T-cell proliferation to regulatory the immune response in many autoimmune disease and organ-rejection treatment. However, the role of sCD83 in the autoimmune uveitis is still not clear. In our study, we show that sCD83 alleviates experimental autoimmune uveitis (EAU) through a novel mechanism. During onset and recovery of EAU, the level of sCD83 rises in the serum and aqueous humor. Systemic or topical application of sCD83 application alleviates the symptom of EAU and decreases the infilt

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Zelek, Wioleta M., Lewis M. Watkins, Owain W. Howell, et al. "Measurement of soluble CD59 in CSF in demyelinating disease: Evidence for an intrathecal source of soluble CD59." Multiple Sclerosis Journal 25, no. 4 (2018): 523–31. http://dx.doi.org/10.1177/1352458518758927.

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Background: CD59, a broadly expressed glycosylphosphatidylinositol-anchored protein, is the principal cell inhibitor of complement membrane attack on cells. In the demyelinating disorders, multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD), elevated complement protein levels, including soluble CD59 (sCD59), were reported in cerebrospinal fluid (CSF). Objectives: We compared sCD59 levels in CSF and matched plasma in controls and patients with MS, NMOSD and clinically isolated syndrome (CIS) and investigated the source of CSF sCD59 and whether it was microparticle associa

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Kang, Seon Mee, Jun Choul Lee, and Bon Jeong Ku. "Changes in Soluble Serum CD81 Concentration during an Oral Glucose Tolerance Test in Patients with Diabetes Mellitus and Individuals with Normal Glucose Tolerance." Diagnostics 13, no. 23 (2023): 3500. http://dx.doi.org/10.3390/diagnostics13233500.

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Aim: Cluster of differentiation 81 (CD81) is a cell surface protein involved in cell development, activation, growth, and motility. Recent studies have suggested that CD81 is a marker of dedifferentiated β-cells under conditions of metabolic stress, such as progressive diabetes. However, the clinical significance of changes in soluble serum CD81 (sCD81) in diabetic individuals remains unknown. The aim of this study was to investigate whether serum sCD81 concentrations differ between subjects with diabetes and normal glucose tolerance (NGT), and whether sCD81 changes during a 75 g oral glucose

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Liu, Shen, Chaoqun Huang, Dawei Li, et al. "Molecular cloning and expression analysis of a new gene for short-chain dehydrogenase/reductase 9." Acta Biochimica Polonica 54, no. 1 (2007): 213–18. http://dx.doi.org/10.18388/abp.2007_3289.

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We report here the cloning and characterization of a novel human short-chain dehydrogenases/reductase gene SCDR9, isolated from a human liver cDNA library, and mapped to 4q22.1 by browsing the UCSC genomic database. SCDR9 containing an ORF with a length of 900 bp, encoding a protein with a signal peptide sequence and an adh_short domain. GFP localization shows SCDR9 protein concentrated in some site of the cytoplasm, but not in the ER. Expression pattern in eighteen tissues revealed that SCDR9 is expressed highly in liver. Soluble recombinant protein was successfully purified from Escherichia

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Einenkel, Rebekka, Katrin Regina Helene Packhäuser, Jens Ehrhardt, Anne Tüngler, Marek Zygmunt, and Damián Oscar Muzzio. "CD83 is locally regulated and differentially expressed in disturbed murine pregnancy." Reproduction 158, no. 4 (2019): 323–33. http://dx.doi.org/10.1530/rep-19-0171.

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Alterations in the immunologic balance during pregnancy have been associated with poor pregnancy outcomes. The underlying mechanisms are complex and mouse models delivered valuable information on inflammatory imbalance in disturbed pregnancies and served as model to test potential anti-inflammatory therapies. CD83 is a transmembrane protein (mCD83) with a soluble form (sCD83) which possesses strong anti-inflammatory properties. During murine pregnancy, upregulated mCD83 expression induces sCD83 release after in vitro stimulation with LPS, phorbol myristate acetate (PMA) and ionomycin. The rele

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Linker-Israeli, M., S. Hyun, T. Ozeri-Chen, D. J. Wallace, K. Banks, and J. R. Klinenberg. "Elevated in vivo and in vitro secretion of CD8-alpha molecules in patients with systemic lupus erythematosus." Journal of Immunology 152, no. 6 (1994): 3158–67. http://dx.doi.org/10.4049/jimmunol.152.6.3158.

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Abstract Endogenously activated CD8+ cells contribute to the aberrant immune regulation that characterizes SLE. Because stimulation of CD8+ cells with lectin/Ag triggers release of CD8-alpha molecules (sCD8), we measured, in patients with SLE, serum sCD8 content, its correlation with disease activity, and the in vitro release of sCD8 by SLE PBMCs. sCD8 levels, measured by ELISA in sera of 50 SLE patients, were higher than normal in 16 out of 21 mildly active and 15 out of 15 active SLE patients. sCD8 correlated positively with the clinical index for disease activity (r = 0.57, p = 0.001) and w

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16

Gong, Xingyu, Tianyi Ma, Qiaoya Zhang, et al. "Porcine Reproductive and Respiratory Syndrome Virus Modulates the Switch of Macrophage Polarization from M1 to M2 by Upregulating MoDC-Released sCD83." Viruses 15, no. 3 (2023): 773. http://dx.doi.org/10.3390/v15030773.

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Porcine reproductive and respiratory syndrome virus (PRRSV), the most economically important infectious disease of pigs, elicits poor innate and adaptive immune responses. Soluble CD83 (sCD83), a secretion from various immune cell populations, especially MoDCs, is involved in negatively regulating the immune response. We speculate sCD83 may be a critical factor in the process of PRRSV-coordinated macrophage polarization. In this study, we found that PAMs co-cultured with PRRSV-infected MoDCs inhibited the M1 macrophage while enhancing the M2 macrophage. This was accompanied by a decrease in th

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Ishibashi, Mariko, Ryosuke Kinoshita, Koiti Inokuchi, et al. "Serum Soluble CD86, Still a Prognostic Factor in the Novel Agent Era in Multiple Myeloma Patients, Is Produced By Myeloma Cells with High CD86 Variant 3 Expression." Blood 134, Supplement_1 (2019): 4361. http://dx.doi.org/10.1182/blood-2019-124635.

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Introduction: We previously reported that CD86 expressed on tumor cells from multiple myeloma (MM) patients is associated with a proliferative advantage of tumor cells and suppresses the antitumor immune response by inducing the immunosuppressive cytokine IL-10 from CD4+ T cells via CD86-CD28 interaction [Yamashita T, Clin Cancer Res 2009]. Furthermore, CD28 expressed on MM cells can mediate pro-survival signaling through CD86-CD28 interaction, resulting in chemotherapeutic resistance [Murray ME, Blood 2014]. Hock et al. reported that serum soluble CD86 levels (sCD86) were a significant indepe

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Muñiz, Carmen, Lourdes Martín-Martín, Antonio López, et al. "Contribution of cerebrospinal fluid sCD19 levels to the detection of CNS lymphoma and its impact on disease outcome." Blood 123, no. 12 (2014): 1864–69. http://dx.doi.org/10.1182/blood-2013-11-537993.

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Key Points Increased levels of sCD19 protein in the CSF are associated with CNS disease in DLBCL and BL patients at risk of CNS lymphoma. Presence of lymphoma cells by FCM and/or increased CSF sCD19 levels are related with a poorer EFS and/or OS in DLBCL and BL patients.

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Ho, AD, M. Grossman, L. Trumper, et al. "Clinical implications of increased plasma levels of CD8 in patients with hairy cell leukemia." Blood 75, no. 5 (1990): 1119–24. http://dx.doi.org/10.1182/blood.v75.5.1119.bloodjournal7551119.

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Plasma levels of soluble T-suppressor/cytotoxic antigen (sCD8) were measured at diagnosis or before systemic treatment in 69 patients with hairy cell leukemia (HCL). The 49 nonsplenectomized patients were characterized by high concentrations of sCD8 antigen as compared with 17 controls (P less than .0001). The median sCD8 level in non- splenectomized patients was 1,050 U/mL (range: 160 to 2,400 U/mL) and was significantly higher (P less than .0001) than the median of 275 U/mL (range: 20 to 1,080 U/mL) in splenectomized patients. The relationship of sCD8 to clinical response to subsequent inter

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Ho, AD, M. Grossman, L. Trumper, et al. "Clinical implications of increased plasma levels of CD8 in patients with hairy cell leukemia." Blood 75, no. 5 (1990): 1119–24. http://dx.doi.org/10.1182/blood.v75.5.1119.1119.

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Abstract Plasma levels of soluble T-suppressor/cytotoxic antigen (sCD8) were measured at diagnosis or before systemic treatment in 69 patients with hairy cell leukemia (HCL). The 49 nonsplenectomized patients were characterized by high concentrations of sCD8 antigen as compared with 17 controls (P less than .0001). The median sCD8 level in non- splenectomized patients was 1,050 U/mL (range: 160 to 2,400 U/mL) and was significantly higher (P less than .0001) than the median of 275 U/mL (range: 20 to 1,080 U/mL) in splenectomized patients. The relationship of sCD8 to clinical response to subsequ

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Eldatarina, Helsa, Handono Kalim, Kusworini Handono, and Mirza Zaka Pratama. "Correlation between sCTLA-4 and sCD86 Levels with Disease Activity of Systemic Lupus Erythematosus (SLE) Patients Based on SLEDAI Score." Indonesian Journal of Rheumatology 16, no. 1 (2024): 830–38. http://dx.doi.org/10.37275/ijr.v16i1.266.

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Background. Systemic Lupus Erythematosus (SLE) is an autoimmune disease with multisystem involvement which arises from multifactorial causes. Continuous exposure to autoantigens and chronic activation of the immune system, especially memory T lymphocytes, contribute to premature immunosenescence. sCTLA-4 and sCD86 are soluble costimulatory molecules of CTLA-4 and CD86, which play a role in the occurrence of immunosenescence in SLE. The presence of immunosenescence will cause higher morbidity and mortality. This research was conducted to establish the correlation between the increased levels of

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Lundell, Anna-Carin, Kerstin Andersson, Elisabet Josefsson, Alexander Steinkasserer, and Anna Rudin. "Soluble CD14 and CD83 from Human Neonatal Antigen-Presenting Cells Are Inducible by Commensal Bacteria and Suppress Allergen-Induced Human Neonatal Th2 Differentiation." Infection and Immunity 75, no. 8 (2007): 4097–104. http://dx.doi.org/10.1128/iai.01744-06.

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ABSTRACT CD14 is expressed on the cell surface of various antigen-presenting cells, and CD83 is a maturation marker for dendritic cells (DC). CD14 and CD83 are also present as soluble proteins, and both have immunoregulatory functions. We examined whether neonatal cord blood monocytes or DC released soluble CD14 (sCD14) or sCD83 when exposed to the commensal intestinal bacteria Clostridium perfringens, Staphylococcus aureus, Lactobacillus rhamnosus, Escherichia coli, and Bacteroides fragilis. We found that the gram-positive bacteria C. perfringens and S. aureus, but not gram-negative bacteria,

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Kogure, T., T. Itoh, Y. Shimada, T. Shintani, H. Ochiai, and K. Terasawa. "Detection of serum soluble markers of immune activation in rheumatoid arthritis." Mediators of Inflammation 5, no. 4 (1996): 262–65. http://dx.doi.org/10.1155/s0962935196000373.

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The mutual correlation among soluble CD4 (sCD4), soluble CD8 (sCD8), and soluble CD23 (sCD23) has not yet been studied in patients with rheumatoid arthritis (RA), although previous studies have demonstrated that certain soluble markers of immune activation are elevated in RA. Thus, we examined this correlation based on the serum levels of sCD4, sCD8 and sCD23, and that of their levels with other serum markers such as immunoglobulin (Ig) subtypes (IgG, IgM and IgA), IgM-rheumatoid factor (IgM-RF) and C-reactive protein (CRP) in 25 RA patients, sCD4 was not elevated, whereas both sCD8 and sCD23

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Olszewski, Jurek, Wiesław Chudzik, Kazimierz Wiśniewski, Jarosław Miłonski, and Robert Matyja. "An Assessment of Concentrations of Soluble CD4 and CD8 Receptors in Serum before and after Surgical Treatment in Patients with Chronic Maxillary Sinusitis." American Journal of Rhinology 17, no. 3 (2003): 123–26. http://dx.doi.org/10.1177/194589240301700301.

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Background The aim of this study was to assess the concentrations of soluble CD4 (sCD4) and sCD8 receptors in serum of patients before and after surgical treatment of chronic maxillary sinusitis. Methods We examined 57 patients, aged 20–63 years (mean age, 41 ± 0.5 years), and divided them into four groups: group I, 14 patients with chronic maxillary sinusitis without allergy; group II, 15 patients with chronic maxillary sinusitis with allergy; group III, 16 patients with cyst of maxillary sinuses without allergy (control); and group IV, 12 patients with cyst of maxillary sinuses with allergy

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Peckert-Maier, Katrin, Dmytro Royzman, Pia Langguth, et al. "Tilting the Balance: Therapeutic Prospects of CD83 as a Checkpoint Molecule Controlling Resolution of Inflammation." International Journal of Molecular Sciences 23, no. 2 (2022): 732. http://dx.doi.org/10.3390/ijms23020732.

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Chronic inflammatory diseases and transplant rejection represent major challenges for modern health care. Thus, identification of immune checkpoints that contribute to resolution of inflammation is key to developing novel therapeutic agents for those conditions. In recent years, the CD83 (cluster of differentiation 83) protein has emerged as an interesting potential candidate for such a “pro-resolution” therapy. This molecule occurs in a membrane-bound and a soluble isoform (mCD83 and sCD83, respectively), both of which are involved in resolution of inflammation. Originally described as a matu

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Kubysheva, Nailya, Larisa Postnikova, Svetlana Soodaeva, et al. "Relationship of the Content of Systemic and Endobronchial Soluble Molecules of CD25, CD38, CD8, and HLA-I-CD8 and Lung Function Parameters in COPD Patients." Disease Markers 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/8216723.

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The definition of new markers of local and systemic inflammation of chronic obstructive pulmonary disease (COPD) is one of the priority directions in the study of pathogenesis and diagnostic methods improvement for this disease. We investigated 91 patients with COPD and 21 healthy nonsmokers. The levels of soluble CD25, CD38, CD8, and HLA-I-CD8 molecules in the blood serum and exhaled breath condensate (EBC) in moderate-to-severe COPD patients during exacerbation and stable phase were studied. An unidirectional change in the content of sCD25, sCD38, and sCD8 molecules with increasing severity

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Yin, Xin-Ke, Chao Wang, Li-Li Feng, et al. "Expression Pattern and Prognostic Value of CTLA-4, CD86, and Tumor-Infiltrating Lymphocytes in Rectal Cancer after Neoadjuvant Chemo(radio)therapy." Cancers 14, no. 22 (2022): 5573. http://dx.doi.org/10.3390/cancers14225573.

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The synergistic effect of combining immune checkpoint inhibitors (ICIs) with neoadjuvant chemo(radio)therapy (nCRT) in colorectal cancer is still limited. We aimed to understand the impact of nCRT on the tumor microenvironment and to explore favorable immune markers of this combination. Herein, we investigated the expression of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), CD86, CD4, and CD8 after nCRT and its association with clinicopathological characteristics. Immunostaining of immune-related molecules was performed in 255 surgically resected specimens from rectal cancer patients tr

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Moretti, Edgardo, Beatriz Basso, Liliana Cervetta, Ana Brigada, and Gustavo Barbieri. "Patterns of Cytokines and Soluble Cellular Receptors in the Sera of Children with Acute Chagas' Disease." Clinical and Vaccine Immunology 9, no. 6 (2002): 1324–27. http://dx.doi.org/10.1128/cdli.9.6.1324-1327.2002.

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ABSTRACT Cytokines and soluble cellular receptors are involved in inflammatory processes and probably in the pathogenesis of parasite and bacterial diseases. In a previous study, we reported increased levels of soluble receptors of interleukin-2 (sIL2-R) in children with acute Chagas' disease, one of the main parasitic infections that is endemic in Latin America. We sought to analyze the pattern of different cytokines and soluble receptors in the sera of children with chagasic infection. Children with acute and indeterminate stages of Chagas' disease, as well as nonchagasic children, were stud

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Jiang, Chun-Xuan. "THE PRIME PRINCIPLE IN CLUSTERS AND NANOSTRUCTURES." Algebras Groups and Geometries 39, no. 2 (2023): 189–95. http://dx.doi.org/10.29083/agg.39.02.2023/sc189.

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Ho, AD, M. Maruyama, A. Maghazachi, JR Mason, S. Gluck, and RE Corringham. "Soluble CD4, soluble CD8, soluble CD25, lymphopoieitic recovery, and endogenous cytokines after high-dose chemotherapy and blood stem cell transplantation." Blood 84, no. 10 (1994): 3550–57. http://dx.doi.org/10.1182/blood.v84.10.3550.3550.

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Abstract Mononuclear cell preparations from peripheral blood after mobilization with hematopoietic growth factors have been shown to induce accelerated neutrophil and platelet recovery as compared with that induced by autologous bone marrow transplantation after myeloablative chemotherapy. Because these mononuclear cell products contain many immunocompetent cells other than hematopoietic progenitors, these accessory cells might contribute to the rapid immunohematopoietic reconstitution. We have monitored the concentrations of soluble CD4 (sCD4), sCD8, and sCD25; the recovery of the lymphocyte

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Ho, AD, M. Maruyama, A. Maghazachi, JR Mason, S. Gluck, and RE Corringham. "Soluble CD4, soluble CD8, soluble CD25, lymphopoieitic recovery, and endogenous cytokines after high-dose chemotherapy and blood stem cell transplantation." Blood 84, no. 10 (1994): 3550–57. http://dx.doi.org/10.1182/blood.v84.10.3550.bloodjournal84103550.

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Mononuclear cell preparations from peripheral blood after mobilization with hematopoietic growth factors have been shown to induce accelerated neutrophil and platelet recovery as compared with that induced by autologous bone marrow transplantation after myeloablative chemotherapy. Because these mononuclear cell products contain many immunocompetent cells other than hematopoietic progenitors, these accessory cells might contribute to the rapid immunohematopoietic reconstitution. We have monitored the concentrations of soluble CD4 (sCD4), sCD8, and sCD25; the recovery of the lymphocyte subsets a

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Ho, AD, R. Haas, G. Wulf, et al. "Activation of lymphocytes induced by recombinant human granulocyte- macrophage colony-stimulating factor in patients with malignant lymphoma." Blood 75, no. 1 (1990): 203–12. http://dx.doi.org/10.1182/blood.v75.1.203.203.

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Abstract To investigate effects of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) on lymphoid cells in vivo, we monitored changes in absolute lymphocyte counts, plasma concentrations of soluble interleukin-2 receptor (sIL-2R) and soluble cytotoxic/suppressor (sCD8) antigens, and phenotypic changes of surface membrane antigens of peripheral mononuclear cells from 14 patients with malignant lymphoma treated with rhGM-CSF. Eight of the 14 patients had relapsed or had refractory non-Hodgkin's lymphoma (NHL) and received rhGM-CSF after intensive chemotherapy with nova

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Ho, AD, R. Haas, G. Wulf, et al. "Activation of lymphocytes induced by recombinant human granulocyte- macrophage colony-stimulating factor in patients with malignant lymphoma." Blood 75, no. 1 (1990): 203–12. http://dx.doi.org/10.1182/blood.v75.1.203.bloodjournal751203.

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To investigate effects of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) on lymphoid cells in vivo, we monitored changes in absolute lymphocyte counts, plasma concentrations of soluble interleukin-2 receptor (sIL-2R) and soluble cytotoxic/suppressor (sCD8) antigens, and phenotypic changes of surface membrane antigens of peripheral mononuclear cells from 14 patients with malignant lymphoma treated with rhGM-CSF. Eight of the 14 patients had relapsed or had refractory non-Hodgkin's lymphoma (NHL) and received rhGM-CSF after intensive chemotherapy with novantrone (N

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Inano, Shojiro, and Toshiyuki Kitano. "A modified CD9 tag for efficient protein delivery via extracellular vesicles." PLOS ONE 19, no. 10 (2024): e0310083. http://dx.doi.org/10.1371/journal.pone.0310083.

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Extracellular vesicles (EVs) are attracting growing attention for therapeutic use and as diagnostic markers, particularly for cancer. Although therapies based on small interfering RNAs are under intensive research, other therapeutic molecules, especially proteins, have not been sufficiently investigated. One of the major method for loading proteins into EVs is electroporation; however, it damages membrane integrity and requires repeated purification, precluding clinical applications. Thus, natural and efficient protein transfer is a prerequisite for the clinical application of protein-based EV

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Putz, D., U. Barnas, A. Luger, G. Mayer, W. Woloszczuk, and H. Graf. "Biocompatibility of High-Flux Membranes." International Journal of Artificial Organs 15, no. 8 (1992): 456–60. http://dx.doi.org/10.1177/039139889201500802.

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Standard dialysis with cuprophane membranes is known to stimulate the immune system. As a result of activation of macrophages various interleukins and tumor necrosis factor (TNF) are secreted, presenting further evidence of the poor biocompatibility of cuprophane. We investigated the immunogenic properties of three modern high-flux membranes. Seven patients were studied during hemodiafiltration sessions using either a polysulfone (F60, Fresenius), a polymethylmetacrylate (BK 2.1, Toray) or a cellulose triacetate (FB-210 U, Nipro) dialyzer in a hemodiafiltration procedure. Serial measurements w

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Hamed, Nahla, Nahla Farahat, Manal El Sorady, Dalia Nafee, and Sherine Barakat. "Clinical significance of sCD86 levels in patients with acute myelogenous leukemia." Alexandria Journal of Medicine 47, no. 1 (2011): 25–30. http://dx.doi.org/10.1016/j.ajme.2011.04.002.

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Nascimento, Catarina, Andreia Gameiro, Jorge Correia, João Ferreira, and Fernando Ferreira. "The Landscape of Tumor-Infiltrating Immune Cells in Feline Mammary Carcinoma: Pathological and Clinical Implications." Cells 11, no. 16 (2022): 2578. http://dx.doi.org/10.3390/cells11162578.

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Feline mammary carcinoma (FMC) shares key molecular and clinicopathological features with human breast cancer. We have herein studied the inflammatory infiltrate of FMC in order to uncover potential therapeutic targets and prognostic markers. To this end, the expression of different markers (CD3, CD4, CD8, CD20, CD56, FoxP3, CD68 and CD163) was analyzed in total, stromal (s) and intratumoral (i) tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs), in 73 feline mammary carcinomas. The results revealed that higher percentages of sCD8+ TILs were associated with longer di

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El-Daly, Mai M., Kawther A. Zaher, Eitezaz A. Zaki, et al. "Immunological and molecular assessment of HIV-1 mutations for antiretroviral drug resistance in Saudi Arabia." PLOS ONE 19, no. 6 (2024): e0304408. http://dx.doi.org/10.1371/journal.pone.0304408.

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Human Immunodeficiency Virus (HIV) is a significant threat to public health. HIV genotyping and antiretroviral resistance testing may have contributed to improved non-treated management. Immune markers might assist HIV-1 diagnosis and drug-resistant variant identification. HIV-1 immunogenicity and molecular characteristics of antiretroviral drug resistance are evaluated in 56 treatment-naive HIV patients. DNA sequencing and retroviral resistance testing identified HIV-1 genotypes. 55.4% of patients were susceptible to protease inhibitors (PI), nucleoside reverse transcriptase inhibitors (NRTI)

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Kashchenko, Mikhail. "INTERPRETATION OF THE MECHANISM OF THE INFLUENCE OF π0- MESONS ON THE PROCESS OF ATTRACTION OF NUCLEI". Hadronic Journal 47, № 1 (2024): 89–94. http://dx.doi.org/10.29083/hj.47.01.2024/sc89.

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Díaz García, Elena, Sara García-Tovar, Enrique Alfaro, et al. "Role of CD39 in COVID-19 Severity: Dysregulation of Purinergic Signaling and Thromboinflammation." IBJ Plus 1, s5 (2022): 1. http://dx.doi.org/10.24217/2531-0151.22v1s5.00001.

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CD39/NTPDase1 has emerged as an important molecule that contributes to maintain inflammatory and coagulatory homeostasis. Various studies have hypothesized the possible role of CD39 in COVID-19 pathophysiology since no confirmatory data shed light in this regard. Therefore, we aimed to quantify CD39 expression on COVID-19 patients exploring its association with severity clinical parameters and ICU admission, while unraveling the role of purinergic signaling on thromboinflammation in COVID-19 patients. We selected a prospective cohort of patients hospitalized due to severe COVID-19 pneumonia (n

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Barlan, Işil B., M. M. Başaran, M. Bakir, F. Tükenmez та Nural Bekiroğlu. "Serum TNF-α, sCD8 and sIL-2R levels in childhood tuberculosis". Infection 23, № 4 (1995): 237–39. http://dx.doi.org/10.1007/bf01781205.

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Pujalte, J. M. "Présence pulmonaire de sCD87 au cours du syndrome de détresse respiratoire aiguë (SDRA)." Revue des Maladies Respiratoires 21, no. 6 (2004): 1212. http://dx.doi.org/10.1016/s0761-8425(04)71619-8.

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Spathas, Nikolaos, Anna C. Goussia, Georgia-Angeliki Koliou, et al. "Association between CD8+ Tumor Infiltrating Lymphocytes and the Clinical Outcome of Patients with Operable Breast Cancer Treated with Adjuvant Dose-Dense Chemotherapy—A 10 Year Follow-Up Report of a Hellenic Cooperative Oncology Group Observational Study." Cancers 14, no. 22 (2022): 5635. http://dx.doi.org/10.3390/cancers14225635.

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Tumor-infiltrating lymphocytes (TILs) contribute to breast cancer (BC) prognosis. We investigated the prognostic impact of CD8+ TILs in patients with early breast cancer treated with adjuvant chemotherapy in a large observational clinical trial. Along with a 10 year follow-up, considering the efficacy and safety, we report the results of the translational part of our study. We examined the patients’ tumors for total (t), stromal (s), and intratumoral (i) CD8 lymphocyte density (counts/mm2) on tissue-microarray cores. The impact of CD8+ TILs counts on DFS and OS, and its correlation with breast

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Ozkorucu, Duygu, Nuran Cetin, Nadide Melike Sav, and Bilal Yildiz. "Urine and serum ghrelin, sCD80 and sCTLA-4 levels in doxorubicin-induced experimental nephrotic syndrome." International Urology and Nephrology 48, no. 7 (2016): 1187–96. http://dx.doi.org/10.1007/s11255-016-1249-4.

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Sanders, David E., Mark S. Stave, Leslie S. Perkins, and Andrew E. DePristo. "SCT89: a computer code for atomic and molecular scattering from clean and adsorbate covered surfaces." Computer Physics Communications 70, no. 3 (1992): 579–608. http://dx.doi.org/10.1016/0010-4655(92)90118-i.

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Buisan, Oscar, Jordi Senserrich, Pol Servian, et al. "CD39 expression as a predictive biomarker for neoadjuvant treatment in muscle-invasive bladder cancer." Journal of Clinical Oncology 43, no. 5_suppl (2025): 850. https://doi.org/10.1200/jco.2025.43.5_suppl.850.

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850 Background: Neoadjuvant therapy before radical cystectomy (RC) is the the standard treatment for muscle-invasive bladder cancer (MIBC). However, a significant number of patients do not respond to these therapies. Identifying biomarkers predictive of treatment response and developing novel therapeutic strategies are crucial to improving patient management and survival. This study aims to investigate non-invasive biomarkers that can predict response to neoadjuvant therapy in MIBC patients and explore their potential use in the design of new therapies. Methods: Immunophenotyping was performed

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De Rie, MA, IM Zonneveld, L. Witkamp, RA Van Lier, TA Out, and JD Bos. "Soluble interleukin-2 receptor (sIL-2R) is a marker of disease activity in psoriasis: a comparison of sIL-2R, sCD27, sCD4, sCD8 and sICAM-1." Acta Dermato-Venereologica 76, no. 5 (1996): 357–60. http://dx.doi.org/10.2340/0001555576357360.

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Psoriasis is a T-cell-mediated inflammatory skin disease which can be treated successfully with immunosuppressive drugs. Our purpose was to evaluate disease activity of psoriasis and the effect of immunosuppressive treatment by monitoring the soluble T-cell products sIL-2R, sCD27, sCD4, sCD8 and sICAM-1. Twenty-two patients were treated orally with escalating dosages of cyclosporin A (n = 17)(3-5 mg/kg/day) or FK506 (n = 5)(0.05-0.15 mg/kg/day). The Psoriasis Area and Severity Index (PASI) was used to monitor clinical activity of psoriasis. Serum samples were analyzed by ELISA. sIL-2R levels s

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Kuryliszyn-Moskal, A., K. Bemacka, and O. Bielecka. "Soluble CD4 (sCD4), CD8 (sCD8) and cytokine levels in rheumatoid arthritis complicated by vasculitis." Immunology Letters 56 (May 1997): 321. http://dx.doi.org/10.1016/s0165-2478(97)86296-7.

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Kuryliszyn-Moskal, A. "Soluble CD4 (sCD4), CD8 (sCD8) and cytokine levels in rheumatoid arthritis complicated by vasculitis." Immunology Letters 56, no. 1-3 (1997): 321. http://dx.doi.org/10.1016/s0165-2478(97)88134-5.

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Brasoveanu, L. I., E. Fonsatti, A. Visintin, et al. "Melanoma cells constitutively release an anchor-positive soluble protectin (sCD59) that retains functional activities in complement-mediated cytotoxicity." Melanoma Research 7, Supplement 1 (1997): S10. http://dx.doi.org/10.1097/00008390-199706001-00034.

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