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Journal articles on the topic 'Schiff bases Compounds'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

1Devendra, K. Singh and 2Vipin K. Singh. "Study of Schiff's bases and its metal complexes for different Applications." Journal of Research & Development' 14, no. 7 (2022): 173–79. https://doi.org/10.5281/zenodo.6988274.

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<strong>Abstract:</strong> The focus on the current study is to investigate that the broad applications of the metal complexes with Schiff’s bases. Schiff’s bases are an important part of medical science. In many drugs, develops activities like antibacterial, antifungal and anticancer. The potency of these pharmaceutically useful drugs is a treatment for microbial infections and other activities that encourages the development of some more potent and momentous complex compounds. Schiff’s bases and their metal complexes are remarkably impressive compounds. On larger-scale bioc

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2

Ahmed, A. A. "Synthesis, Characterization of New di Schiff base Derivatives from Dapsone, Their Polymerization and Thermal study." BASRA JOURNAL OF SCIENCE 39, no. 3 (2021): 463–83. http://dx.doi.org/10.29072/basjs.2021309.

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Schiff bases were containing (-C=N-) functional group and found to be a versatile compound. In this study new three Schiff bases compounds were prepared in the presence of catalyst through condensation products of 4,4'-sulfonyldianiline with carbonyl compounds using microwave. These compounds characterized by using FTIR, H-NMR and Mass spectroscopy. Also, they were polymerized to produce poly ester and phenolic resin through condensation polymerization, their thermal stability was evaluate using (TGA and DSC) techniques, the result show that the polymers have decomposition temperature more tha

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3

Iacopetta, Domenico, Jessica Ceramella, Alessia Catalano, et al. "Schiff Bases: Interesting Scaffolds with Promising Antitumoral Properties." Applied Sciences 11, no. 4 (2021): 1877. http://dx.doi.org/10.3390/app11041877.

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Schiff bases, named after Hugo Schiff, are highly reactive organic compounds broadly used as pigments and dyes, catalysts, intermediates in organic synthesis, and polymer stabilizers. Lots of Schiff bases are described in the literature for various biological activities, including antimalarial, antibacterial, antifungal, anti-inflammatory, and antiviral. Schiff bases are also known for their ability to form complexes with several metals. Very often, complexes of Schiff bases with metals and Schiff bases alone have demonstrated interesting antitumor activity. Given the innumerable vastness of d

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4

Kajal, Anu, Suman Bala, Sunil Kamboj, Neha Sharma, and Vipin Saini. "Schiff Bases: A Versatile Pharmacophore." Journal of Catalysts 2013 (August 27, 2013): 1–14. http://dx.doi.org/10.1155/2013/893512.

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Schiff bases are condensation products of primary amines with carbonyl compounds gaining importance day by day in present scenario. Schiff bases are the compounds carrying imine or azomethine (–C=N–) functional group and are found to be a versatile pharmacophore for design and development of various bioactive lead compounds. Schiff bases exhibit useful biological activities such anti-inflammatory, analgesic, antimicrobial, anticonvulsant, antitubercular, anticancer, antioxidant, anthelmintic, antiglycation, and antidepressant activities. Schiff bases are also used as catalysts, pigments and dy

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5

Sona, B. Warrier and Prashant S. Kharkar*. "DESIGN, SYNTHESIS AND CHARACTERIZATION OF FLUORESCENT PROBES BASED ON SCHIFF BASES." Indo American Journal of Pharmaceutical Sciences 04, no. 06 (2017): 1505–10. https://doi.org/10.5281/zenodo.815365.

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Abstract: Schiff bases of fluorescein were synthesized from fluorescein hydrazide using different aromatic aldehydes. These compounds show bright fluorescence different from that of starting material, fluorescein. The compounds were characterised by spectroscopic methods. Absorption and fluorescence spectra of the compounds were also recorded. Keywords: Fluorescein, Schiff bases, Fluorescein hydrazide, fluorescent probes, fluorescence

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6

SEKAR, PRAVEEN, SHRIDHARSHINI KUMAR, and Senthil Kumar Raju. "A Review on Chemistry, Synthesis and Biological Applications of Chalcone-based Schiff Bases." Journal of Drug Delivery and Therapeutics 13, no. 3 (2023): 145–54. http://dx.doi.org/10.22270/jddt.v13i3.5969.

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Heterocyclic compounds are an important class of compounds in the field of pharmaceutical and synthetic organic chemistry. The Schiff bases contain azomethine linkages which are obtained by the condensation of aldehyde/ketone with amines. Among the various types of Schiff bases, the chalcone-based Schiff bases play a vital role in the treatment of various ailments and various applications, which can be synthesized by using different types of chalcones as the starting materials. These types of compounds were synthesized by using various techniques like conventional means of synthesis, microwave

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7

Raczuk, Edyta, Barbara Dmochowska, Justyna Samaszko-Fiertek, and Janusz Madaj. "Different Schiff Bases—Structure, Importance and Classification." Molecules 27, no. 3 (2022): 787. http://dx.doi.org/10.3390/molecules27030787.

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Schiff bases are a vast group of compounds characterized by the presence of a double bond linking carbon and nitrogen atoms, the versatility of which is generated in the many ways to combine a variety of alkyl or aryl substituents. Compounds of this type are both found in nature and synthesized in the laboratory. For years, Schiff bases have been greatly inspiring to many chemists and biochemists. In this article, we attempt to present a new take on this group of compounds, underlining of the importance of various types of Schiff bases. Among the different types of compounds that can be classi

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8

Senthil, Kumar Raju, Settu Archana, Thiyagarajan Archana, Rama Divya, Sekar Praveen, and Kumar Shridharshini. "Biological applications of Schiff bases: An overview." GSC Biological and Pharmaceutical Sciences 21, no. 3 (2022): 203–15. https://doi.org/10.5281/zenodo.7654212.

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Schiff bases are the compounds containing the azomethine group (-HC=N-). They are formed by the condensation of ketones or aldehydes with a primary amine. Formation of Schiff base generally takes place under acid/base catalysis or with heat. The common Schiff bases are crystalline solids, which are basic but at least some form insoluble salts with strong acids. Schiff bases are used as intermediates for the synthesis of amino acids or as ligands for the preparation of metal complexes having a series of different structures. The electrophilic carbon and nucleophilic nitrogen in the C=N imine bo

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9

Laddha, Purushottam R., and Kailash R. Biyani. "Synthesis and Biological Evaluation of Novel Schiff Bases of Aryloxy Moiety." Journal of Drug Delivery and Therapeutics 9, no. 5-s (2019): 44–49. http://dx.doi.org/10.22270/jddt.v9i5-s.3635.

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Schiff's bases are condensation products of primary amines with carbonyl compounds. Schiff bases (imines) possess wide variety of biological activities that include antibacterial and antifungal activity. In present work, Schiff bases from 3,5- Dimethoxyphenol (aryloxy moiety) as starting material synthesized. Esterification of 3,5- Dimethoxyphenol led to formation of (3,5-Dimethoxy-phenoxy)-acetic acid ethyl ester (1). (3,5-Dimethoxy-phenoxy)-acetic acid hydrazide (2) is derived from Compound (1) by hydrazination. Compound (2) was reacted with different aromatic aldehydes to yield novel imines

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10

Senthil Kumar Raju, Archana Settu, Archana Thiyagarajan, Divya Rama, Praveen Sekar, and Shridharshini Kumar. "Biological applications of Schiff bases: An overview." GSC Biological and Pharmaceutical Sciences 21, no. 3 (2022): 203–15. http://dx.doi.org/10.30574/gscbps.2022.21.3.0484.

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Schiff bases are the compounds containing the azomethine group (-HC=N-). They are formed by the condensation of ketones or aldehydes with a primary amine. Formation of Schiff base generally takes place under acid/base catalysis or with heat. The common Schiff bases are crystalline solids, which are basic but at least some form insoluble salts with strong acids. Schiff bases are used as intermediates for the synthesis of amino acids or as ligands for the preparation of metal complexes having a series of different structures. The electrophilic carbon and nucleophilic nitrogen in the C=N imine bo

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11

Abdelnabi, S., Chasib K. Bkhakh, and Mouayed Y. Kadhum. "Synthesis , spectroscopic characterization and biological study of some new Schiff bases based on 2-hydroxybenzadehyde." JOURNAL OF ADVANCES IN CHEMISTRY 13, no. 2 (2017): 5995–6005. http://dx.doi.org/10.24297/jac.v13i12.6117.

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Four new Schiff bases were synthesized from condensation of aldehyde ( 2-hydroxy benzaldehyde ) with aromatic amines (4-introaniline ; 4,4-oxydianiline ; 4,4-diaminodipleny sulfone and sulfanilamide) . These Schiff bases were characterized by IR, NMR , GC. mass and element analysis. Moreover, the Schiff bases were screened for their antibacterial and antifungal activity against various microorganisms and compared with standard compounds. In general , the results were indicated that some Schiff bases had good antimicrobial activity.

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12

Senthil, Kumar Raju, Settu Archana, Thiyagarajan Archana, Rama Divya, Sekar Praveen, and Kumar Shridharshini. "Synthetic approaches of medicinally important Schiff bases: An updated Review." World Journal of Advanced Research and Reviews 16, no. 3 (2022): 838–52. https://doi.org/10.5281/zenodo.7903785.

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The Schiff base defined by an imine or azomethine (-CH= N-) group, is mostly synthesized by the condensation reaction of carbonyl compounds (Aldehyde or Ketone) with compounds consisting of amine moiety. Schiff bases are among the most chiefly used organic compounds, revealing a wide range of applications, such as electroluminescent effects, fluorescence properties, nonlinear optical and chemosensory properties. The typical Schiff bases are crystalline solids that are basic, although at least some of them combine with strong acids to generate insoluble salt. Schiff bases are widely used in the

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13

Senthil Kumar Raju, Archana Settu, Archana Thiyagarajan, Divya Rama, Praveen Sekar, and Shridharshini Kumar. "Synthetic approaches of medicinally important Schiff bases: An updated Review." World Journal of Advanced Research and Reviews 16, no. 3 (2022): 838–52. http://dx.doi.org/10.30574/wjarr.2022.16.3.1394.

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The Schiff base defined by an imine or azomethine (-CH= N-) group, is mostly synthesized by the condensation reaction of carbonyl compounds (Aldehyde or Ketone) with compounds consisting of amine moiety. Schiff bases are among the most chiefly used organic compounds, revealing a wide range of applications, such as electroluminescent effects, fluorescence properties, nonlinear optical and chemosensory properties. The typical Schiff bases are crystalline solids that are basic, although at least some of them combine with strong acids to generate insoluble salt. Schiff bases are widely used in the

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14

Odularu, Ayodele Temidayo. "Manganese Schiff Base Complexes, Crystallographic Studies, Anticancer Activities, and Molecular Docking." Journal of Chemistry 2022 (August 24, 2022): 1–19. http://dx.doi.org/10.1155/2022/7062912.

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Choice of ligands is significant to successful synthesis of metal complexes (coordination compounds). This study reports the use of Schiff base as the right ligand to control the poor bioavailability and neurodegenerative toxicity challenges of manganese ion. In line with this study, document analysis was used as the methodological approach to evaluate the significance of Schiff base ligands in easing these manganese’s challenges and aligning the resultant coordination compounds (manganese Schiff base complexes) as therapeutic agents in anticancer studies. Report also involves crystallographic

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15

Panda, Jnyanaranjan. "Synthesis and Biological Evaluation of Some Isatin-based Mannich Bases." International Journal of Pharmaceutical Sciences and Nanotechnology 5, no. 4 (2013): 1841–46. http://dx.doi.org/10.37285/ijpsn.2012.5.4.3.

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 In this study, a series of isatin-based Mannich bases were prepared and their biological activity was evaluated. Schiff bases of isatin were synthesized by condensation of the keto group of isatin with different aromatic primary amines. The N-Mannich bases of the above Schiff bases were synthesized by reaction of the acidic imino group of isatin with formaldehyde and secondary amine. The chemical structures of the title compounds have been confirmed and elucidated by means of their physical and spectral data respectively. The compounds were tested for their possible antibacterial, analg

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16

Varma, Madhuri, Suhas Janwadkar, Himani More, and Mrunmayi Churi. "A review on applications of Schiff bases and their comparison in different field." International Journal of Advance and Applied Research 6, no. 25(A) (2025): 31–34. https://doi.org/10.5281/zenodo.15296298.

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<strong>Abstract: </strong> Schiff bases are adaptable organic compounds that are commonly synthesized through the condensation of various amino compounds with aldehydes or ketones, forming imines. These Schiff base ligands are regarded as privileged ligands due to their straightforward synthesis via condensation. They exhibit a wide range of applications in fields such as medicine, pharmaceuticals, coordination chemistry, biological activities, industries, food packaging, dyes, and polymers, and are also utilized as oxygen detectors. Transition metal complexes, such as those containing copper

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17

Al-Asadi, Rafid H., Tarik A. Fahad, Bahjat A. Saeed, and Wasfi A. Al-Masoudi. "Synthesis, Characterization and Antitumor Activity of Some New Oganotellurium Compounds Containing Azomethine Group, Part One." JOURNAL OF ADVANCES IN CHEMISTRY 8, no. 1 (2016): 1464–71. http://dx.doi.org/10.24297/jac.v8i1.4027.

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New tellurated schiff bases were synthesized by the reaction of the corresponding mercurated Schiff bases compounds A1-A3 with tellurium tetrabromide in 1:1 mole ratio and that gave organyltellurium tribromides A4-A6. On the other hand, when mercurated schiff bases and tellurium tetrabromide brought together in 2:1 mole ratio gave diorganyltellurium dibromides compounds A10-A12 followed by reduction with hydrazine hydrate gave new diorganyl tellurides A13-A15. Reduction of compounds A4-A6 by hydrazine hydrate gave new ditellurides A7-A9. All compounds were characterized by elemental analysis,

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18

Raju, Senthil Kumar, Shridharshini Kumar, and Praveen Sekar. "Synthetic methodologies and pharmacological applications of sulphonamide containing Schiff bases and their metal complexes: A comprehensive review." IP International Journal of Comprehensive and Advanced Pharmacology 8, no. 1 (2023): 10–21. http://dx.doi.org/10.18231/j.ijcaap.2023.002.

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Schiff bases are useful chemical compounds with a wide range of applications. The Schiff bases are synthesized via the condensation reaction between carbonyl compounds (aldehydes or ketones) and compounds having an amine group and the Schiff base is characterised by an imine or azomethine (-C=N-) group. These compounds are extensively used as ligands to form coordination complexes with metal ions and are widely utilized in the treatment of various ailments. Sulphonamides are biologically significant class of drug-like chemical derivatives due to their good oral absorption and urine excretion.

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19

Venkatachalam, T. K., Gregory K. Pierens, and David Reutens. "Synthesis and Characterization of Anils Exhibiting Thermochromism." Australian Journal of Chemistry 63, no. 8 (2010): 1272. http://dx.doi.org/10.1071/ch09579.

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Several Schiff bases containing a hydroxy naphthyl moiety and substituted pyridyl groups were synthesized. The pyridyl substituted Schiff bases were isolated as a single stable tautomer at room temperature. High-resolution proton and carbon NMR spectroscopy showed that these compounds exist as keto tautomers. The Schiff bases showed extraordinary stability and did not convert to the enol tautomer, even at high temperatures. Most of the compounds exhibited thermochromic properties.

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20

Akitsu, Takashiro, Daisuke Nakane, and Barbara Miroslaw. "Viewpoints Concerning Crystal Structure from Recent Reports on Schiff Base Compounds and Their Metal Complexes." Symmetry 16, no. 11 (2024): 1525. http://dx.doi.org/10.3390/sym16111525.

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Schiff bases are organic compounds that are often used as ligands in metal complexes. In addition to the C=N double bond, which is characteristic of Schiff bases, intermolecular hydrogen bonds are frequently observed in both the twisting of planar substituents in organic compounds and the geometric structure of the coordination environment in metal complexes. The results of the crystal structure analyses are stored in databases, which can be used to assess three-dimensional structures. To examine the important structural aspects for novel molecular and material designs, this review examines th

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21

Devkota, Kishor, Govinda Pathak, and Bhushan Shakya. "Synthesis and Evaluation of Schiff Bases of 4-Amino-5-(chlorine substituted phenyl)-4H-1,2,4-triazole-3-thione as Antimicrobial Agents." Journal of Nepal Chemical Society 41, no. 1 (2020): 26–35. http://dx.doi.org/10.3126/jncs.v41i1.30373.

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Triazole ring system has attracted a continuously growing interest of synthetic organic chemists and those dealing with the medicinal compounds due to its versatile potential to interact with biological systems. Schiff bases are also considered as one of the most biologically active compounds. The aim of the present study was to synthesize new Schiff bases bearing triazole nucleus and to assess their antimicrobial activities. Four new Schiff base derivatives of 1,2,4-triazole-3-thione were synthesized by combining two different pharmacophores viz. triazole nucleus and Schiff base moiety and we

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22

GODWIN, JACKSON, OGUARABAU BENSON, ODONTIMI NIMIGHAYE, and EMMANUEL P. SALVATION. "Schiff Bases, Syntheses, Characterisation and their Application to Heavy Metal Removal: A Review." International Journal of Research and Innovation in Applied Science IX, no. V (2024): 94–107. http://dx.doi.org/10.51584/ijrias.2024.905008.

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Schiff bases are compounds resulting from the condensation reaction between an aldehyde or ketone with primary amines. The confirmation of the formation of these compounds involves the use of characterisation techniques which encompasses spectroscopic and thermoanalytical techniques. Recently, Schiff bases have garnered attention because of their wide applications which range from industrial uses to use in remediation of metal ions. Their use in extraction of heavy metal is of particular interest due to rising levels of metal pollution globally. The ability of Schiff bases to form coordination

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23

Almarhoon, Zainab M., Wedad A. Al-Onazi, Asma A. Alothman, Amal M. Al-Mohaimeed, and Eida S. Al-Farraj. "Synthesis, DNA Binding, and Molecular Docking Studies of Dimethylaminobenzaldehyde-Based Bioactive Schiff Bases." Journal of Chemistry 2019 (July 1, 2019): 1–14. http://dx.doi.org/10.1155/2019/8152721.

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A new series of p-dimethylaminobenzaldehyde derivatives were tested for therapeutic potential by exploring their properties through characterization. The derivatives were synthesized by 1 : 1 condensation reaction of p-dimethylaminobenzaldehyde and substituted amines. The synthesized compounds 1–8 were characterized by different characterization techniques including IR, mass, 1H NMR, and 13C NMR spectroscopy, elemental analysis, and mass spectrometry. Furthermore, binding of these Schiff bases to Ct-DNA was examined by absorption spectroscopy, fluorescence quenching, circular dichroic, viscosi

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24

Anand, P., V. M. Patil, V. K. Sharma, R. L. Khosa, and N. Masand. "Schiff bases: A Review on Biological Insights." International Journal of Drug Design and Discovery 3, no. 3 (2025): 851–68. https://doi.org/10.37285/ijddd.3.3.5.

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Schiff bases derived from various heterocyclic compounds displayed broad range of biological activities such as anticancer, antiviral, antimicrobial, anticonvulsant, antidepressant, angiotension-II receptor antagonist, anti-inflammatory and anti-glycation activity. So far, modifications of the Schiff bases have proven highly effective with improved potency and lesser toxicity. The present review highlights the recently synthesized Schiff bases possessing important biological activities.

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Bhowmik, K. R. Nath. "Biomedical Applications of Some Schiff Bases and Their Transition Metal Complexes: A Review." Asian Journal of Chemistry 36, no. 11 (2024): 2485–500. http://dx.doi.org/10.14233/ajchem.2024.32594.

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A diverse class of compounds known as Schiff bases and their metal complexes are synthesized via condensation of amino and carbonyl compounds. Schiff bases and their metal complexes have several applications in analytical, pharmacological, organic, bioinorganic, and material research, which has increased interest in this class of molecule. In a variety of reactions, even in the presence of moisture, many Schiff base metal complexes have outstanding catalytic activity. Schiff bases serve as versatile pharmacophores due to their ability to bind with metals of different oxidation states to form c

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Abood S Huda, Abdullah S. Asia, and Wrewish S Zainab. "Synthesis, characterization and antibacterial studies of Schiff bases of acyclovir." International Journal of Research in Pharmaceutical Sciences 11, no. 1 (2020): 411–15. http://dx.doi.org/10.26452/ijrps.v11i1.1835.

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There is a crucial medical need for the progress of new antibacterial agents with new and more efficient mechanisms. Schiff bases are stated to have a wide range of pharmacological activities, including antimicrobial, antibacterial, antifungal, antioxidant, and anticancer activities, which are largely due to the distinguishing C=N group. Furthermore, heterocyclic compounds containing acyclic hydroxylated side chains, for example, acyclovir (ACV), are an essential class of antiviral acyclonucleosides. Therefore, this work was to synthesize and evaluate a new series of acyclovir analogues bearin

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Husain, Asif, Munendra M. Varshney, Versha Parcha, Aftab Ahmad, and Shah A. Khan. "Nalidixic Acid Schiff Bases: Synthesis and Biological Evaluation." Letters in Drug Design & Discovery 15, no. 1 (2018): 103–11. http://dx.doi.org/10.2174/1570180814666170710160751.

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Background: The prevalence of morbidity and mortality due to infections from parasitic worms and protozoa is on rise especially in third world countries. The situation is further worsened by drug resistant microbial pathogens. Objectives: The antimicrobial and anthelmintic activities associated with substituted furfuraldehyde and 1,8-naphthyridine nucleus of nalidixic acid prompted us to synthesize some new quinolone Schiff bases with an aim to obtain potent antibacterial and anthelmintic agents with improved safety and efficacy. Methods: A new series of 1,8 naphthyridine based Schiff bases we

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Porto, Ricardo Silva. "Computational investigation of Schiff bases from tryptamine as COX-2 inhibitors with potential anti-inflammatory activity." JOURNAL OF RESEARCH AND KNOWLEDGE SPREADING 3, no. 1 (2022): e13081. http://dx.doi.org/10.20952/jrks3113081.

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Non-steroidal anti-inflammatory drugs are the most used drugs to inhibit cyclooxygenases (COX). Understanding the structure of COX isoforms is required for the research for more selective and less toxic anti-inflammatory agents. Also, computational methods can help to predict drug interaction. In this work, tryptamine Schiff bases, retrieved from literature, were screened to evaluate their ADMET profiles. After the initial screening, the compounds with better parameters were subjected to molecular docking interactions with the crystal structure of the COX-2 enzyme to verify binding affinities

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Z. Naji, Hussam, and Eman M. Hussain. "Synthesis, Characterization and Evaluation of the Biological Activity of Some New Thiazolidine Derivatives Derived from Schiff bases." Sumer 3 8, CSS 3 (2023): 1–11. http://dx.doi.org/10.21931/rb/css/2023.08.03.20.

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In this research, new compounds were synthesized via the reaction of dichloroacetic acid with two moles of piperidine. The novel acid 1 was converted to its ester 2. Acid hydrizide 3 was prepared by the reaction of hydrazine hydrate with new ester 2, which was later used to prepare derivatives of Schiff bases 4-13. In the last step, Schiff bases and thioglycolic acid were reacted to give thiazolidine derivatives 14-23. All these compounds were diagnosed using melting points, FTIR, 1HNMR and mass spectroscopy. Scheme 1 shows all the synthesized compounds' reaction steps and structures. Keywords

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V., J. Patro, S. Panda C., M. Sahoo B., K. Mishra N., and R. Panda J. "Synthesis and screening for antibacterial, analgesic and anti-inflammatory activity of Mannich bases derived from 1H-indole-2,3-dione." Journal of Indian Chemical Society Vol. 89, Jul 2012 (2012): 913–18. https://doi.org/10.5281/zenodo.5766824.

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Department of Pharmaceutical Chemistry, Roland Institute of Pharmaceutical Sciences, Berhampur-760 010, Orissa, India <em>E-mail</em> : jrpanda77@gmail.com Department of Pharmaceutical Chemistry, Indira Gandhi Institute of Pharmaceutical Sciences, Bhubaneswar, Orissa, India <em>Manuscript received 04 February 2011, revised 16 June 2011, accepted 08 November 2011</em> The reaction of isatin (1<em>H</em>-indole-2,3-dione) with substituted anilines in presence of acetic acid produces Schiff bases. Reaction of the Schiff bases with different secondary amines in presence of formaldehyde yields Mann

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Mohammed, Haneen J., and M. S. Magtoof. "Microwave assisted Synthesis of Some New 1,3-Oxazepines from Schiff Bases." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 34, no. 01 (2024): 77. http://dx.doi.org/10.59467/ijhc.2024.34.77.

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The synthesis of four new 1,3-oxazepines was accomplished by the reaction between maleic anhydride with Schiff bases. The Schiff-bases (a1-a2) were prepared from the reaction of aromatic aldehyde with aromatic amines. The newly synthesized compounds were characterized by spectral (FlT-IR, 1H NMR, 13C NMR) and elemental analytical data.. KEYWORDS :1,3- Oxazepine, DMF, Maleic anhydride, Schiff-bases.

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Khalefa, Omar S. "New Schiff base compounds with benzene moiety: FT-IR, 1H and 13C NMR Spectroscopy (1D) studies." BASRA JOURNAL OF SCIENCE 38, no. 1 (2020): 98–110. http://dx.doi.org/10.29072/basjs.20200105.

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New Schiff bases compounds containing benzene moiety has been synthesized from reaction between (4-(((4-(Alkyloxy) benzylidene) amino) methyl) phenyl)methan amine and 4-((6-bromohexyl) oxy)benzaldehyde or 4-(4-bromobutoxy)benzaldehyde. FT-IR of these compounds have been studied. The complete 1H and 13C NMR assignment of these compounds has been obtained using one-dimensional NMR techniques including 1H and 13C experiments. The data deduced from this study show that the alkyl chain and the phenyl rings are in different planes compared to the benzene ring.

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Khalefa, Omar S. "New Schiff base compounds with benzene moiety: FT-IR, 1H and 13C NMR Spectroscopy (1D) studies." BASRA JOURNAL OF SCIENCE 38, no. 1 (2020): 98–110. http://dx.doi.org/10.29072/basjs.20200108.

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New Schiff bases compounds containing benzene moiety has been synthesized from reaction between (4-(((4-(Alkyloxy) benzylidene) amino) methyl) phenyl)methan amine and 4-((6-bromohexyl) oxy)benzaldehyde or 4-(4-bromobutoxy)benzaldehyde. FT-IR of these compounds have been studied. The complete 1H and 13C NMR assignment of these compounds has been obtained using one-dimensional NMR techniques including 1H and 13C experiments. The data deduced from this study show that the alkyl chain and the phenyl rings are in different planes compared to the benzene ring.

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Junne, S. B., Archana B. Kadam, S. L. Shinde, G. S. Waghamare, and Y. B. Vibhute. "Synthesis, Characterization and Antibacterial Activity of Some Halo Substituted Schiff Bases." E-Journal of Chemistry 7, no. 3 (2010): 882–86. http://dx.doi.org/10.1155/2010/571309.

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Some new halo substituted Schiff bases have been prepared from different aromatic aldehydes and a series of substituted aromatic amines to form a number of potentially biologically active compounds. The structures of the Schiff bases have been characterized by using IR and1HNMR spectroscopy. These compounds were screened against human pathogenic bacteria by agar diffusion method. Ampicillin was used as control.

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Mammadova, P. Sh, E. R. Babayev, and L. A. Mehdieva. "THE USE OF SCHIFF BASES AS CORROSION INHIBITORS." World OF PETROLEUM PRODUCTS 7 (2023): 20–26. http://dx.doi.org/10.32758/2782-3040-2023-0-7-20-26.

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The presented article shows the results of research in the field of application of Schiff bases as corrosion inhibitors. Literary sources report a wide range of applications for Schiff bases. It is noted. that azomethines (another name for Schiff bases) contain an imine group, which is obviously responsible for the presence of anticorrosive properties of these compounds. In addition, the paper shows the results of the authors' own research.

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Blagus, Anita, Dominik Cinčić, Tomislav Friščić, Branko Kaitner, and Vladimir Stilinović. "Schiff bases derived from hydroxyaryl aldehydes: molecular and crystal structure, tautomerism, quinoid effect, coordination compounds." Macedonian Journal of Chemistry and Chemical Engineering 29, no. 2 (2010): 117. http://dx.doi.org/10.20450/mjcce.2010.159.

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During the last 50 years a vast number of structural studies on Schiff bases derived from hydroxyaryl aldehydes and their coordination compounds have been undertaken. In this review we present a systematic and brief overview of the most important discoveries and achievements accomplished in this field. The occurrence of Schiff bases (and their complexes) derived from nine most commonly used hydroxyaryl aldehydes in the Cambridge Structural Database (CSD) has been investigated. Keto-enol tautomerism and intramolecular hydrogen bonding in salicylaldimines and naphthaldimines is discussed, with a

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Mohammad, Zainab Hashim, Diana AbdAlkreem Al-Rifaie, and Malath Khalaf Rasheed. "Synthesis, characterization, antioxidant, and antibacterial activities of Schiff bases and thiazinan 4-ones derived from minoxidil." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 35, no. 02 (2025): 531. https://doi.org/10.59467/ijhc.2025.35.531.

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The study reports the synthesis and biological activities of some new Schiff bases and thiazinan-4-ones staring from minoxidil. Schiff bases (M1-M7) were prepared by the reaction of minoxidil with various aromatic aldehydes. The thiazinan-4-ones were obtained through the cyclization of Schiff bases (M5, M6) with cysteine (MS5, MS6). All the compounds were characterized by spectral data (FT-IR, 1H NMR, and mass including fragmentation pathways). The synthesized compounds (M1, M2, M3, M5, M6, MS5 and MS6) were evaluated for their anti-oxidant properties utilizing the reducing power and total ant

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Březina, František, and Zdeněk Šindelář. "Complex nickel compounds with Schiff bases derived from diacetylmonoxime." Collection of Czechoslovak Chemical Communications 51, no. 4 (1986): 830–35. http://dx.doi.org/10.1135/cccc19860830.

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Schiff bases derived from diacetylmonoxime and ethylenediamine or diethylenetriamine give Ni(HDEM)ClO4, Ni(HDEM) (ClO4)Br, Ni(H2DTM)Br2.2 H2O and Ni(H2DTM)Br4 complex compounds. H2DTM splits in solution in the presence of triethylamine, owing to which Ni(DAO) (dien)Cl complex could be isolated. The possibility of Employing the above Schiff bases for the preparation of compounds involving nickel in a higher valency state is discussed.

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Sabah, Noor, Zainab Esmail Sadeq, Hiba Shihab Ahmed, Mostefe Khalid Mohammed, and Anfal Salam Al-Mahdawi. "Green Synthesis Methods of Schiff Base Compounds: A Review." Iraqi Journal of Natural Sciences and Nanotechnology 5 (April 2, 2024): 38–56. https://doi.org/10.47758/ijnsn.v5i1.111.

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Synthesis of Schiff bases using the principles of green chemistry is an environmentally friendly approach to obtain these important organic compounds. Schiff bases are widely utilized in various applications, but traditional synthesis methods often involve the use of toxic reagents and solvents. This review highlights a sustainable and ecological strategy for the preparation of the Schiff base. The green chemistry method emphasizes the selection of non-toxic and readily available starting materials, such as primary amines and carbonyl compounds, while minimizing waste generation and energy con

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Rawat, Rhambus, Prem Shankar Deo, and Bhushan Shakya. "Synthesis, Characterization and Study of Antimicrobial Activities of Mannich Bases Incorporating 1,2,4-Triazole Nucleus." Amrit Research Journal 2, no. 01 (2021): 19–27. http://dx.doi.org/10.3126/arj.v2i01.39894.

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Heterocyclic compounds containing triazole moiety have great importance in the field of medicine, pharmaceuticals, biochemistry, biology, therapeutics, environmental science, and industry. Triazoles and their derivatives have been extensively used in the development of new drugs. Biological activities of Schiff bases are highly investigated, but Mannich bases are on the verge of their development, and they are being synthesized in large number nowadays. In this work, Mannich bases are synthesized by incorporation 1,2,4-triazole moiety through Schiff base using different amines. Mannich bases a

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Journal, Baghdad Science. "Synthesis, Characterization and Antimicrobial activity Study Via some new Schiff bases for Trimethoprim." Baghdad Science Journal 7, no. 1 (2010): 614–20. http://dx.doi.org/10.21123/bsj.7.1.614-620.

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This search reports the synthesis of some new series of Schiff base compounds for trimetheprim derivatives which known high been known as a medicinal effectiveness. Trimetheprim was condensed with several substituted aldehydes compounds.(4-dimethyl amine benzaldehyde , propanal , salicaldehyde, 2.4 dimethoxy benzaldehyde and 4- methyl benzaldehyde) to obtain Schiff base products(1a-5a) and several substituted ketones compound (4-aminoacetophenone,4-chloroacetophenone, isobutyleketone, acetylacetone and acetophenone) to obtain Schiff base products(6b-10b) in ethanol in the presence of concentra

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Naglah, Ahmed M., Abdulrahman A. Almehizia, Asma S. Al-Wasidi, et al. "Exploring the Potential Biological Activities of Pyrazole-Based Schiff Bases as Anti-Diabetic, Anti-Alzheimer’s, Anti-Inflammatory, and Cytotoxic Agents: In Vitro Studies with Computational Predictions." Pharmaceuticals 17, no. 5 (2024): 655. http://dx.doi.org/10.3390/ph17050655.

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In this innovative research, we aim to reveal pyrazole-based Schiff bases as new multi-target agents. In this context, we re-synthesized three sets of pyrazole-based Schiff bases, 5a–f, 6a–f, and 7a–f, to evaluate their biological applications. The data from in vitro biological assays (including antioxidant and scavenging activities, anti-diabetes, anti-Alzheimer’s, and anti-inflammatory properties) of the pyrazole-based Schiff bases 5a–f, 6a–f, and 7a–f showed that the six pyrazole-based Schiff bases 5a, 5d, 5e, 5f, 7a, and 7f possess the highest biological properties among the compounds eval

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Happy, Kamrunnahar, Sumaiya Khan, Umme Aiman Liza, Afsana Mimi, Md Rafikul Islam та Mohammad Mamun Hossain. "Synthesis of some 2-azitidinones (β-lactams) as antibiotic mimics and screening of their antimicrobial activity". Journal of Bangladesh Academy of Sciences 48, № 1 (2024): 111–19. http://dx.doi.org/10.3329/jbas.v48i1.71538.

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2-Azetidinones (β-lactams) possess broad and potent bioactivity owing to the presence of lactam rings. As evidence has shown, it is one of the most critical biological frameworks. Some new 2- azetidinones have been synthesized from corresponding Schiff bases using different amines and aldehydes. All compounds (Schiff bases and β- lactams) were synthesized for comparison research using conventional and microwave techniques. The microwave approach has been found to reduce reaction time and boost yield drastically. Analysis combining elemental (C, H, and N) and spectroscopic approaches (NMR, IR,

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Malakyan, Margarita, Nelly Babayan, Ruzanna Grigoryan, et al. "Synthesis, characterization and toxicity studies of pyridinecarboxaldehydes and L-tryptophan derived Schiff bases and corresponding copper (II) complexes." F1000Research 5 (August 5, 2016): 1921. http://dx.doi.org/10.12688/f1000research.9226.1.

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Schiff bases and their metal-complexes are versatile compounds exhibiting a broad range of biological activities and thus actively used in the drug development process. The aim of the present study was the synthesis and characterization of new Schiff bases and their copper (II) complexes, derived from L-tryptophan and isomeric (2-; 3-; 4-) pyridinecarboxaldehydes, as well as the assessment of their toxicity in vitro. The optimal conditions of the Schiff base synthesis resulting in up to 75-85% yield of target products were identified. The structure-activity relationship analysis indicated that

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Dr., Faizan Sayeed1* Abdul Sayeed1 MD Akram1 Mohd Waseem Akram2. "DESIGN, SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF NEW SUBSTITUTED THIAZOLIDIN-4- ONE DERIVATIVES." Indo American Journal of Pharmaceutical Sciences 04, no. 08 (2017): 2461–72. https://doi.org/10.5281/zenodo.846845.

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4-thiazolidinones are among t h e most extensively investigated class of organic compounds. Thiazolidin-4-one has been considered as magic moiety, which is a core structure in various synthetic pharmaceuticals displaying a broad spectrum of biological activities.They are widely used as anti-inflammatory, anticonvulsant, analgesic, antimicrobial,anti-HIV,CNS depressant, carcinostatic, antihypertensive and cytotoxic. In view of the wide spectrum activities of condensed 4-thiazolidinones, it was thought worthwhile to undertake the synthesis of heterocyclic systems in which 4-thiazolidinone nucleu

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Govindarao, K., N. Srinivasan, R. Suresh, and K. Ravi Shankar. "SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF NOVEL QUINOLINE BASED 2-AZETIDINONES AND 4-THIAZOLIDINONES." INDIAN DRUGS 55, no. 09 (2018): 15–23. http://dx.doi.org/10.53879/id.55.09.11341.

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The present work describes the synthesis of a series of quinoline based 4-thiazolidinone and 2-azetidinone derivatives from Schiff bases obtained from the condensation of 2-chloro-3-formylquinoline and 3-4-aminoacetophenones. Quinoline based 4-thiazolidinone and 2-azetidinone derivatives have been prepared by the reaction of various substituted Schiff base with thioglycholic acid and chloroacetyl chloride, respectively. The intermediate Schiff bases were synthesized by the condensation of different quinoline aldehydes with amino acetophenones. The starting compound i.e aldehyde was synthesized

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Khan, Khalid A., Hassan M. Faidallah, and Abdullah M. Asiri. "Synthesis and Biological Evaluation of New N,N′-Bis(1-substituted-ethylidene)-ethane1,2-diamine and Their Acetyl and Trifluoroacetyl Derivatives as Cytotoxic and Antimicrobial Agents." Journal of Chemistry 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/478635.

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Several Schiff bases2have been prepared by the condensation of various methyl ketones1with 1,2-ethylenediamine. Subsequent acylation of these Schiff bases with trifluoroacetic anhydride in THF yields the corresponding trifluoroacetyl derivatives3. However,o-hydroxy- ando-methoxy-substituted derivatives yielded substituted-trifluoromethylchroman-4-ones. Additionally, Schiff bases when reacted with acetic anhydride afforded the C-acetylated derivatives4. The structures of the isolated compounds were fully determined by spectral methods. Preliminary biological screening of the prepared compounds

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C., Mallikarjunaswamy*1 V. Lakshmi Ranganatha2 L. Mallesha1 D.G. Bhadregowda3. "NOVEL PYRIMIDINE SCHIFF BASES: SYNTHESIS AND PHARMACOLOGICAL SCREENING." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 01 (2017): 7329–39. https://doi.org/10.5281/zenodo.1005166.

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Schiff bases are aldehydelike compounds in which an imine group replaces the carbonyl group. They are widely used for industrial purposes and also exhibit a broad range of biological activities. This study represents the synthesis of a new series of (E) -N-benzylidene-5-bromo-2-chloropyrimidin-4-amine derivatives (6a-l). The newly synthesized compounds were characterized by different spectral studies. All these new compounds screened for their anti-inflammatory, antimicrobial and in vitro antioxidant activities. Structure–activity relationship analysis demonstrates that hydroxyl groups on the

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Divya, Kumble, Geetha M. Pinto, and Asha F. Pinto. "APPLICATION OF METAL COMPLEXES OF SCHIFF BASES AS AN ANTIMICROBIAL DRUG: A REVIEW OF RECENT WORKS." International Journal of Current Pharmaceutical Research 9, no. 3 (2017): 27. http://dx.doi.org/10.22159/ijcpr.2017.v9i3.19966.

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Schiff bases are versatile ligands which are synthesized from the condensation of primary amines with carbonyl groups. Synthesis of Schiff base transition metal complexes by using Schiff base as ligands appears to be fascinating in view of the possibility of obtaining coordination compounds of unusual structure and stability. These transition metal complexes have received exceptional consideration because of their active part in metalloenzymes and as biomimetic model compounds due to their closeness to natural proteins and enzymes. These compounds are very important in pharmaceutical fields be

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Wady, Asha F., Mohammed B. Hussein, and Muna M. Mohammed. "Synthesis, characterisation of schiff bases generated from salicylaldehyde with certain amino acids using a new established technique." Asian Journal of Material Science and Engineering 1, no. 1 (2022): 11–19. http://dx.doi.org/10.53402/ajmse.v1i1.75.

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Amino acids are compounds that consist of an amine group, a carboxylic acid group, and a variable side chain. These molecules are very significant in biochemistry. Amino acids with uncharged amino groups can also undergo Schiff base production at physiological PH levels, presenting an additional possible pathway for metal complexes. In this investigation, four novel Schiff-base amino acid compounds were identified: 5Chlorosalcialdehyde-glycine (H2L1), 5-Chlorosalycialdehyde-alanine (H2L2), 5-Nitrosalycialdehyde-glycine (H2L3), and 5Nitrosalycialdehyde-alanine (H2L4) (H2L4). Condensation reacti

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