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Journal articles on the topic 'Schiff bases Pyrimidine'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

C., Mallikarjunaswamy*1 V. Lakshmi Ranganatha2 L. Mallesha1 D.G. Bhadregowda3. "NOVEL PYRIMIDINE SCHIFF BASES: SYNTHESIS AND PHARMACOLOGICAL SCREENING." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 01 (2017): 7329–39. https://doi.org/10.5281/zenodo.1005166.

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Schiff bases are aldehydelike compounds in which an imine group replaces the carbonyl group. They are widely used for industrial purposes and also exhibit a broad range of biological activities. This study represents the synthesis of a new series of (E) -N-benzylidene-5-bromo-2-chloropyrimidin-4-amine derivatives (6a-l). The newly synthesized compounds were characterized by different spectral studies. All these new compounds screened for their anti-inflammatory, antimicrobial and in vitro antioxidant activities. Structure–activity relationship analysis demonstrates that hydroxyl groups on the

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2

Chandrashekaraiah, Mallikarjunaswamy, Mallesha Lingappa, Vathsala Deepu Channe Gowda, and Doddamedur Giddegowda Bhadregowda. "Synthesis of Some New Pyrimidine-Azitidinone Analogues and Their Antioxidant,In VitroAntimicrobial, and Antitubercular Activities." Journal of Chemistry 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/847180.

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A series of 1-(3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)-4-methylphenyl)-3-chloro-4-(2-mercaptoquinolin-3-yl)azetidin-2-one (7a-j) have been synthesized from the condensation of aromatic amines withN-phenylacetamide. The thione nucleus formed from 2-chloroquionoline-3-carbadehyde using sodium sulphide in dimethyl formamide (DMF) was followed by the reaction with pyrimidine amine to form the Schiff base intermediates. Attempt has been made to derive final azetidinone analogues from Schiff bases by using chloroacetyl chloride. The newly synthesized analogues were examined for the antimicrobial act

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3

Bhusari, Nilesh, Abhay Bagul, Vipin Kumar Mishra, Aisha Tufail, Digambar Gaikwad, and Amit Dubey. "Sustainable synthesis of Schiff base derivatives via an ionic liquid and a microwave-assisted approach: structural, biological, and computational evaluation." RSC Advances 15, no. 28 (2025): 22764–88. https://doi.org/10.1039/d5ra02622a.

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A microwave-assisted method was developed for synthesizing novel 4-amino-pyrrolo[2,3-d]pyrimidine-based Schiff bases (APR1a–d), using ionic liquid [HMIM][TFSI] as both catalyst and solvent, offering a green and efficient approach.

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4

Hegab, Mohamed I., Nasser A. Hassan, and Farouk M. E. Abdel-Megeid. "Three-component Reaction of Cycloheptanone, 6-Amino-1,3-Dimethyluracil and Aromatic Aldehydes; X-Ray Structure, and Anti-inflammatory Evaluation of the Products." Zeitschrift für Naturforschung B 63, no. 9 (2008): 1117–26. http://dx.doi.org/10.1515/znb-2008-0917.

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1,3-Dimethyl-5-aryl-1,6,7,8,9,10-hexahydrocyclohepta[5,6]pyrido[2,3-d]pyrimidine-2,4-diones 4a, b (the linear regioisomers) and the Schiff bases, 6-N-benzylidenamino-1,3-dimethyluracil derivatives 5a, b, were isolated from a three-component reaction of cycloheptanone, 6-amino-1,3- dimethyluracil, and 4-chloro- or 4-bromobenzaldehyde. Surprisingly, 1,3-dimethyl-10-aryl-1,5,6,7, 8,9-hexahydrocyclohepta[4,5]pyrido-[2,3-d]pyrimidine-2,4-diones 6f, g (the angular regioisomers which are described for the first time in the literature under the given reaction conditions) and the Schiff bases, 6-N-benz

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5

Bryndal, Iwona, Marcin Stolarczyk, Aleksandra Mikołajczyk, et al. "Pyrimidine Schiff Bases: Synthesis, Structural Characterization and Recent Studies on Biological Activities." International Journal of Molecular Sciences 25, no. 4 (2024): 2076. http://dx.doi.org/10.3390/ijms25042076.

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Recently, 5-[(4-ethoxyphenyl)imino]methyl-N-(4-fluorophenyl)-6-methyl-2-phenylpyrimidin-4-amine has been synthesized, characterized, and evaluated for its antibacterial activity against Enterococcus faecalis in combination with antineoplastic activity against gastric adenocarcinoma. In this study, new 5-iminomethylpyrimidine compounds were synthesized which differ in the substituent(s) of the aromatic ring attached to the imine group. The structures of newly obtained pyrimidine Schiff bases were established by spectroscopy techniques (ESI-MS, FTIR and 1H NMR). To extend the current knowledge a

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6

Tomma, Jumbad H., Mustafa S. Khazaal, and Ammar H. Al-Dujaili. "Synthesis and characterization of novel Schiff bases containing pyrimidine unit." Arabian Journal of Chemistry 7, no. 1 (2014): 157–63. http://dx.doi.org/10.1016/j.arabjc.2013.08.024.

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7

S., V. Manohare, and S. Thakare S. "Synthesis and Spectral Characterization of Pyrimidine Based 2-Azetidinones." International Journal of Current Science Research and Review 06, no. 05 (2023): 3059–63. https://doi.org/10.5281/zenodo.7988935.

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Abstract : In this study we report the synthesis of a series of 2-Azetidinones from N-(4-(5-bromothiophen-2-yl)-6-(4-chlorophenyl)pyrimidin-2- yl)-1-(aryl) methanimine. A mixture of N-(4-(5-bromothiophen-2-yl)-6-(4-chlorophenyl)pyrimidin-2- yl)-1-(aryl) methanimine and triethyl amine was reacted with chloroacetyl chloride in 1,4-dioxane. The N-(4-(5-bromothiophen-2-yl)-6-(4 -chlorophenyl) pyrimidin-2- yl)-1-(aryl) methanimine was prepared from reaction of  4-(5-bromothiophene-2-yl)-6-(4-chloropheneyl)pyrimidin-2-amine with aromatic aldehydes in ethanol in presence of catalytic acetic acid

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8

Kareem, May Joda. "Synthesis, Spectroscopic Study and Biological Activity of new Bidentate Schiff Base (4-(Dimethylamino) Benzylidene)-5-(3,4,5-Trimethoxybenzyl)-5 Pyrimidine-2,4-Diamine) and Transition Metal Mn(II), Ni(II) and Cu(II) Complexes." Pakistan Journal of Medical and Health Sciences 16, no. 5 (2022): 655–59. http://dx.doi.org/10.53350/pjmhs22165655.

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The Schiff bases ligand (L1) was synthesized by condensing (2,4-diamine (Trimethoxybenzyl 3,4,5)-5 pyrimidine) and (4-dimethylamino benzaldehyde). The transition metal complexes of [Mn(L1)2Cl2], [Ni(L1)2Cl2], and [Cu (L1)2Cl2] were then produced. The ligand and its metal complexes Mn(II), Ni(II), and Cu(II) were examined by analyzing the elemental composition, the metal content, the chloride content, and the molar conductance, FT-IR, 1H-NMR, UV-Vis spectra, magnetic susceptibility, mass spectra, and thermal analysis (TGA). The results indicated that the ligand behaves as a bidentate ligand in

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9

Issa, Yousry M., A. L. El Ansary, O. E. Sherif, and H. B. Hassib. "Charge–transfer complexes of pyrimidine Schiff bases with aromatic nitro compounds." Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 79, no. 3 (2011): 513–21. http://dx.doi.org/10.1016/j.saa.2011.03.022.

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10

Li, Mou-Cui, Ying-Hui Ren, Yu-Ying Han, et al. "Novel Pyrimidine-Triazole Schiff Bases: Synthesis, Antifungal Activities, DFT and Molecular Docking." Revista de Chimie 72, no. 4 (2021): 65–74. http://dx.doi.org/10.37358/rc.21.4.8457.

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Seven 4-amino-5-substituted-1,2,4-triazole-3-thione Schiff base compounds were synthesized reacting 4-amino-5-substituted-1,2,4-triazole-3-thione with dichloro-substituted 5-pyrimidines, and the structures were verified by elemental analysis and spectroscopic techniques (FT-IR, 1H NMR). Additionally, in vitro antifungal activities of the compounds (named F1~F2; A1~A5) against Grape anthracnose and Wheat gibberellic have been evaluated. The compounds of F1, A4 and A5 were found to be potentially effective antifungal agents against Grape anthracnose, while the others showed the low bioactivity.

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11

Sur, Bimanesh, Shyama Prosad Chatterjee, Pratima Sur, Tapas Maity, and Shyamal Roychoudhury. "Studies on the Antineoplasticity of Schiff Bases Containing 5-Nitrofuran and Pyrimidine." Oncology 47, no. 5 (1990): 433–38. http://dx.doi.org/10.1159/000226864.

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12

M. T. Tawfiq. "Synthesis and Characterization of Some New Heterocyclic Compounds Via Unsaturated Ketone with Evaluating of Their biological Activity." Journal of the College of Basic Education 21, no. 88 (2023): 49–76. http://dx.doi.org/10.35950/cbej.v21i88.9952.

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This work includes preparing of some new derivatives of pyrimidine , pyrazole , and isoxazole from the reaction between  benzylideneacetophenone (chalcone) (1) and hydrazine derivatives in the presence of sodium acetate and dry acetone to obtain heterocyclic compounds (2-6).  Reaction of (2) with different substituted benzaldehydes in absolute ethanol and drops of glacial acetic acid gave Schiff bases derivatives (8- 10) respectively. Schiff bases (8-10) were reacted with sodium azide in THF to give tetrazole derivatives (11-13). Reac

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13

Shukkur, A. Hamed, Athraa Thaker, Bilal Majid Rudaini, Hasanain Salah Naeem, Muntaz Abu Bakar, and Siti Aishah Hasbullah. "Synthesis and Characterization of Hexahydropyrimidines and Their New Derivatives." Sains Malaysiana 53, no. 4 (2024): 839–50. http://dx.doi.org/10.17576/jsm-2024-5304-09.

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Three new hexahydropyrimidine derivatives 1a – 1c were successfully synthesized using the Mannich-type reaction. Furthermore, the synthesis of three amino bases 2a – 2c was achieved through the reduction reaction of pyrimidine compounds using hydrazine, followed by the substitution reaction of nitro groups at diverse positions. Subsequently, one of the synthesized amino base derivatives 2c underwent conversion into seven Schiff bases 3a – 3g via a condensation reaction involving the aforementioned amino base derivative and a selection of benzaldehyde derivatives. Four amide compounds 4a – 4d h

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14

Rasheed, Anaam M., Sinan M. M. Al-Bayati, Dr Rehab A. M. Al-Hasani, and Muna Ali Shakir. "Synthesizing, Structuring, and Characterizing Bioactivities of .Cr(III), La(III), and Ce(III) .Complexes with Nitrogen, Oxygen .and Sulpher donor bidentate Schiff base ligands." Baghdad Science Journal 18, no. 4(Suppl.) (2021): 1545. http://dx.doi.org/10.21123/bsj.2021.18.4(suppl.).1545.

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Two Schiff bases, namely, 3-(benzylidene amino) -2-thioxo-6-methyl 2,5-dihydropyrimidine-4(3H)-one (LS])and 3-(benzylidene amino)-6-methyl pyrimidine 4(3H, 5H)-dione(LA)as chelating ligands), were used to prepare some complexes of Cr(III), La(III), and Ce(III)] ions. Standard physico-chemical procedures including metal analysis M%, element microanalysis (C.H.N.S) , magnetic susceptibility, conductometric measurements, FT-IR and UV-visible Spectra were used to identify Metal (III) complexes and Schiff bases (LS) and (LA). According to findings, a [Cr(III) complex] showed six coordinated octahed

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15

Abu-Hashem, Ameen Ali, and Sami A. Al-Hussain. "Design, Synthesis, Antimicrobial Activity, and Molecular Docking of Novel Thiazoles, Pyrazoles, 1,3-Thiazepinones, and 1,2,4-Triazolopyrimidines Derived from Quinoline-Pyrido[2,3-d] Pyrimidinones." Pharmaceuticals 17, no. 12 (2024): 1632. https://doi.org/10.3390/ph17121632.

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Background: Recently, pyrido[2,3-d] pyrimidine, triazolopyrimidine, thiazolopyrimidine, quinoline, and pyrazole derivatives have gained attention due to their diverse biological activities, including antimicrobial, antioxidant, antitubercular, antitumor, anti-inflammatory, and antiviral effects. Objective: The synthesis of new heterocyclic compounds including 5-quinoline-pyrido[2,3-d] pyrimidinone (1–2, 4, 6–7), 6-quinoline-pyrido[2,3-d]thiazolo[3,2-a]pyrimidinone (3, 5, 8–10), 1,2,4-triazole-6-quinoline-pyrido[2,3-d]thiazolo[3,2-a]pyrimidinone (11–13), and pyrido[2,3-d]thiazolo[3,2-a]pyrimidi

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16

García-Raso, Angel, Juan J. Fiol, Adela López-Zafra, et al. "Different ways of interaction between binary copper(II)-Schiff bases (Cu–N-salicylideneserinato) and pyrimidine derivatives." Polyhedron 25, no. 11 (2006): 2295–302. http://dx.doi.org/10.1016/j.poly.2006.01.032.

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17

Pandeya, S. N., D. Sriram, G. Nath, and E. De Clercq. "Synthesis and antimicrobial activity of Schiff and Mannich bases of isatin and its derivatives with pyrimidine." Il Farmaco 54, no. 9 (1999): 624–28. http://dx.doi.org/10.1016/s0014-827x(99)00075-0.

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18

Devim, Mahmut, Senem Akkoç, Celal Tuğrul Zeyrek, Halime Güzin Aslan, and Zülbiye Kökbudak. "Design, synthesis, in vitro antiproliferative activity properties, quantum chemical and molecular docking studies of novel Schiff bases incorporating pyrimidine nucleus." Journal of Molecular Structure 1254 (April 2022): 132421. http://dx.doi.org/10.1016/j.molstruc.2022.132421.

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19

Jone Kirubavathy, S., and S. Chitra. "Structural, theoretical investigations and biological evaluation of Cu(II), Ni(II) and Co(II) complexes of mercapto-pyrimidine schiff bases." Journal of Molecular Structure 1147 (November 2017): 797–809. http://dx.doi.org/10.1016/j.molstruc.2017.07.019.

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20

Ostrowski, S., and A. M. Wolniewicz. "An approach to fused pyrimidine derivativesvia Schiff bases of aromaticortho-nitrocarbaldehydes. An investigation of substituent effects on the reaction course." Chemistry of Heterocyclic Compounds 36, no. 6 (2000): 705–13. http://dx.doi.org/10.1007/bf02297680.

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21

KROKAN, Hans E., Rune STANDAL, and Geir SLUPPHAUG. "DNA glycosylases in the base excision repair of DNA." Biochemical Journal 325, no. 1 (1997): 1–16. http://dx.doi.org/10.1042/bj3250001.

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A wide range of cytotoxic and mutagenic DNA bases are removed by different DNA glycosylases, which initiate the base excision repair pathway. DNA glycosylases cleave the N-glycosylic bond between the target base and deoxyribose, thus releasing a free base and leaving an apurinic/apyrimidinic (AP) site. In addition, several DNA glycosylases are bifunctional, since they also display a lyase activity that cleaves the phosphodiester backbone 3′ to the AP site generated by the glycosylase activity. Structural data and sequence comparisons have identified common features among many of the DNA glycos

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22

Ostrowski, S., and A. M. Wolniewicz. "ChemInform Abstract: An Approach to Fused Pyrimidine Derivatives via Schiff Bases of Aromatic ortho-Nitrocarbaldehydes. An Investigation of Substituent Effects on the Reaction Course." ChemInform 32, no. 19 (2001): no. http://dx.doi.org/10.1002/chin.200119135.

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23

Soni, Hetal I., and Navin B. Patel. "PYRIMIDINE INCORPORATED SCHIFF BASE OF ISONIAZID WITH THEIR SYNTHESIS, CHARACTERIZATION AND IN VITRO BIOLOGICAL EVALUATION." Asian Journal of Pharmaceutical and Clinical Research 10, no. 10 (2017): 209. http://dx.doi.org/10.22159/ajpcr.2017.v10i10.19302.

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Objective: Versatile biological activities of nitrogen containing heterocycles in medicinal chemistry, mainly pyrimidine and pyridine ring based heterocyclic moieties are very important. Pharmaceutical important of pyrimidine and isoniazid moiety prompted us to synthesize isoniazid clubbed pyrimidine derivatives and evaluated for antimicrobial and antituberculosis activity.Method: 2-(2-(3-bromo benzylidene)-1-isonicotinoyl hydrazinyl)-N-(4-(substituted phenyl)-6-(substituted aryl) pyrimidin-2-yl) acetamide 2(A-J) have been synthesized by condensation reaction of 2-chloro-N-[4-(substituted phen

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24

Karati, Dipanjan. "In-silico approach: docking study of novel Schiff base congeners of pyrimidine nucleus." Journal of Analytical & Pharmaceutical Research 11, no. 1 (2022): 17–19. http://dx.doi.org/10.15406/japlr.2022.11.00396.

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Pyrimidine nucleus has a wide spectrum use in medicinal chemistry. Based on structure activity relationship of pyrimidine nucleus we are going to synthesize 4-amino-2-methyl-6-phenylpyrimidine-5-carbonitrile derivatives. In this structure one primary amine group is free at 4th position. Schiff base has excellent antibacterial, antifungal, antiviral activities due to presence of azomethine (CH=N) group. Schiff base compounds have extensive applications in various fields such as analytical, inorganic, organic, and biological fields. They have excellent pharmacology application prospects in the m

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25

Pranay, Shah, I. Patel R., and J. Vyas P. "Preparation and Biological Screening of Novel Heterocyclic Compounds." International Journal of Trend in Scientific Research and Development 3, no. 3 (2019): 632–36. https://doi.org/10.31142/ijtsrd22815.

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The Pyrimidone derivatives say, N arylidine 6 methyl 2 oxo 4 phenyl 1,2,3, 4 tetrahydropyrimidonecarbohydrazides 2a e were synthesized by condensation of Benzaldehyde derivatives with 6 Methyl 2 oxo 4 phenyl 1,2,3,4 tetrahydro pyrimidone carbohydrazides 1 in good yield. The so called hydrazone were cyclocondensed with succinic anhydride to afford 1 6 methyl 2 oxo 4 phenyl 1,2,3, 4 tetrahydropyrimidone 5 carboxamido 5 oxo 2 aryl pyrrolidine 3 carboxylic acid 3a e . These 3a e on Mannich reaction with formaldehyde and morpholine offered 2 aryl 1 6 methyl 2 oxo 4 phenyl 1, 2, 3, 4 tetrahydropyrim

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26

Halah Hameed Majeed and Abbas F. Abbas. "Synthesis ,Characterization and Antioxidant Activity of Schiff base derivatives from [6,6'-(1,4-phenylene)bis(4-(4-aminophenyl) pyrimidin)]." Journal of Kufa for Chemical Sciences 3, no. 1 (2023): 313–44. http://dx.doi.org/10.36329/jkcm/2023/v3.i1.12098.

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Two Hetreterocyclic compounds prepared from condensation reaction of Bis chalcone([3,3(1,4-phenylene)bis(1(4-aminophenyl)prop-2-en-1-one]with thiourea and urea By condensing a novel six-member heterocyclic (pyrimidene ring) with the suitable aromatic, new substituted azomethines of (o, m, and p) hydroxybenzaldehyde with heterocyclic substituents were created. By using NMR and FTIR spectroscopy, the novel heterocyclic compounds and these derivatives of schiff bases were identified.A DPPH free radical scavenging assay was performed on the synthesized compounds, and the heterocyclic substituted t

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27

K. Khatab, Tamer, and Ashraf S. Hassan. "Computational molecular docking and in silico ADMET prediction studies of pyrazole derivatives as Covid-19 main protease (MPRO) and papain-like protease (PLPRO) inhibitors." Bulletin of the Chemical Society of Ethiopia 37, no. 2 (2022): 449–61. http://dx.doi.org/10.4314/bcse.v37i2.14.

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ABSTRACT. The inhibition of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) and papain-like protease (PLpro) prevents viral multiplications. Molecular docking, absorption, distribution, metabolism, excretion, and toxicity (ADMET) studies of pyrazole-indole molecules 6a, b, Schiff bases 8a, b, and pyrazolo[1,5-a]pyrimidines 10a, b were performed and done. Based on the molecular docking study verified that the presented structures (6a, 6b, 8a, 8b, 10a, and 10b) give promised attached bonds with the active site in the COVID-19 main protease (Mpro). The results of

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28

Bagheri, Fatemeh, and Abolfazl Olyaei. "A novel approach toward the synthesis of some new tridentate Schiff bases from anil-like compounds." Journal of the Serbian Chemical Society 81, no. 10 (2016): 1111–19. http://dx.doi.org/10.2298/jsc151202064b.

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A novel method was developed for synthesizing a series of new three dentate Schiff base ligands starting from hydroxynaphthalidene pyrimidinyl amines with o-phenylenediamines or o-aminophenol or 2-amino-3-hydroxy-pyri-dine in the presence of formic acid catalyst under solvent-free conditions. In these reactions [1+1] condensation product as half-unit ligand was obtained. Moreover, the reaction of hydroxynaphthalidene pyrimidinyl amines with 3,4-diamino-pyridine and 1,8-naphthalenediamine lead to the formation of C2-naphthylated imidazopyridine and dihydropyrimidine, respectively. The attractiv

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29

Amal S. Sadiq. "Synthesis of N-Substituted 3-Chloro- 2-azetidinones for 2, 4-diamino-6- hydroxy pyrimidin." Journal of the College of Basic Education 21, no. 88 (2023): 13–24. http://dx.doi.org/10.35950/cbej.v21i88.9949.

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This search involved synthesis of several new N-Substituted -3-chloro- 2-azetidinones which were known as a high medicinal effectiveness for 2, 4-Diamino-6-hydroxy pyrimidin in two steps. The first step included preparation Shiff bases (1-6) by condensation of 2, 4-Diamino-6-hydroxy pyrimidin with many substituted aldehydes(4-hydroxy benzaldehyde, 2- bromobenzaldehyde, 4-dimethyl amino benzaldehyde, = 4-nitro benzaldehyde, salicylaldehyde, 4-chlorobenzaldehyde), then the second step included, preparation new six azetidinones compounds (7-12) by r

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30

D, Mohanambal, and Arulantony S. "SYNTHESIS, SPECTRAL CHARACTERIZATION OF SCHIFF BASE COMPLEXES BASED ON PYRIMIDINE MOIETY WITH MOLECULAR DOCKING WITH BIOMOLECULES." Asian Journal of Pharmaceutical and Clinical Research 11, no. 10 (2018): 93. http://dx.doi.org/10.22159/ajpcr.2018.v11i10.26823.

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Objective: Aim of this study is to synthesize new bidentate complexes of type MX2. nH2O with 4 amino antipyrine and ethyl 4-methyl-2-oxo-6- phenylhexahydropyrimidine-5-carboxylate (DHPM) and to characterize their properties, namely elemental analysis, conductivity measurements, and spectral characteristics and to establish the binding between the Schiff base ligands and complexes with human epidermis cancer cells (Hep-2) through molecular docking.Method: A new bidentate complexes were synthesized by condensation reaction of MX2·nH2O (M = Cu (II), Zn (II), Co (II)) with 4-aminoantipyrine (A) an

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31

Mekala, Himabindu, Rambabu Palabindela, Prabhakar Myadaraveni, Devendar Banothu, Gangalla Ravi та Mamatha Kasula. "MOLECULAR DOCKING INVESTIGATIONS OF THIOSEMICARBAZONE Cu(II) and Zn(II) METAL COMPLEXES AGAINST EGFR, HER2, AND IKK-β TARGET PROTEINS: SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL SCREENING". RASAYAN Journal of Chemistry 16, № 03 (2023): 1309–18. http://dx.doi.org/10.31788/rjc.2023.1636895.

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Cu(II) and Zn(II) complexes of Schiff bases produced from thiosemicarbazone with Anthracene, indole, pyrimidines, and chromones have been synthesized and physiochemically characterized. Among the synthesized ligands L1-L4, the first three ligands behave as uninegative bidentate ones towards Cu(II) and Zn(II) metals, whereas the L4 ligand behaves as a uninegative tridentate one. The structure and bonding properties of the complexes have been investigated using electronic and HRMS-spectral data. All the ligands and complexes were tested for their anti-cancer and anti-bacterial activities. Dockin

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32

Alkış, Mehmet Eşref, Ünzile Keleştemür, Yusuf Alan, Nevin Turan, and Kenan Buldurun. "Cobalt and ruthenium complexes with pyrimidine based schiff base: Synthesis, characterization, anticancer activities and electrochemotherapy efficiency." Journal of Molecular Structure 1226 (February 2021): 129402. http://dx.doi.org/10.1016/j.molstruc.2020.129402.

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HASSAN, Ashraf Sayed, Taghrid Shoukry HAFEZ, Souad Abdel Meguid OSMAN, and Mamdouh Moawad ALI. "Synthesis and in vitro cytotoxic activity of novel pyrazolo[1,5-$a$]pyrimidines and related Schiff bases." TURKISH JOURNAL OF CHEMISTRY 39 (2015): 1102–13. http://dx.doi.org/10.3906/kim-1504-12.

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Gulcan, Mehmet, Sadin Özdemir, Abdurrahman Dündar, Esin İspir, and Mükerrem Kurtoğlu. "Mononuclear Complexes Based on Pyrimidine Ring Azo Schiff-Base Ligand: Synthesis, Characterization, Antioxidant, Antibacterial, and Thermal Investigations." Zeitschrift für anorganische und allgemeine Chemie 640, no. 8-9 (2014): 1754–62. http://dx.doi.org/10.1002/zaac.201400078.

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Saleem, Shahul Hameed Sukkur, Murugesan Sankarganesh, Paul Raj Adwin Jose, Karunganathan Sakthikumar, Liviu Mitu, and Jeyaraj Dhaveethu Raja. "Investigation of Antimicrobial, Antioxidant, and DNA Binding Studies of Bioactive Cu(II), Zn(II), Co(II), and Ni(II) Complexes of Pyrimidine Derivative Schiff Base Ligand." Journal of Chemistry 2017 (2017): 1–8. http://dx.doi.org/10.1155/2017/3831507.

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A new pyrimidine based Schiff base ligand (HL) and its four complexes of type [MLOAc]·nH2O (Cu(II), 1; Zn(II), 2; Co(II), 3; and Ni(II), 4) have been synthesized and characterized by elemental analysis, MS, 1H-NMR, FT-IR, UV-visible, and ESR techniques. The electronic and ESR spectral data suggested that complexes 1–4 possess square planar geometry. Antimicrobial activities of HL and complexes 1–4 were tested against four bacteria (Staphylococcus aureus, Staphylococcus pneumonia, Salmonella enterica typhi, and Haemophilus influenzae) and two fungal strains (Aspergillus flavus and Aspergillus n

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Mehranpour, Abdolmohammad, Elham Sheikhi, Enayatollah Bahman Jahromi, and Ziba Rafiee Samani. "Synthesis of novel Schiff bases as stable enol‐imine‐containing diazene bonds and pyrimidines using trimethinium salts." Journal of Heterocyclic Chemistry 59, no. 2 (2021): 258–63. http://dx.doi.org/10.1002/jhet.4379.

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Kinsuk, Das, Pal Pampi, Dhara Anamika, and Jana Atanu. "Quantifying intermolecular interaction of one trinuclear ZnII and one mononuclear CdII complex of pyrimidine based hexadentate Schiff base : Insights from Hirshfeld surface analysis." Journal of Indian Chemical Society Vol. 93, Jan 2016 (2016): 115–23. https://doi.org/10.5281/zenodo.5607275.

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Department of Chemistry, Chandernagore College, Hooghly-712 136, West Bengal, India <em>E-mail</em> : kdaschem@yahoo.in Ghoshpara Nischinda Balika Vidyapith, Bally, Howrah-711 227, West Bengal, India Department of Chemistry, Jadavpur University, Jadavpur, Kolkata-700 032, India Department of Chemistry, Indian Institute of Technology Delhi, Hauz Khas, New Delhi-110 016, India Department of Chemistry, University College of Science, University of Calcutta, 92, Acharya Prafulla Chandra Road, Kolkata-700 091, India <em>E-mail</em> : atanujanaic@gmail.com <em>Manuscript received online 24 July 2014,

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Ghosh, Swadesh, Dipti Singharoy, Saugata Konar, Jnan Prakash Naskar, and Subhash Chandra Bhattacharya. "Solvatochromic behavior of a pyrene-pyrimidine-based Schiff base and detection of heavy metal ions in aqueous media." Journal of Coordination Chemistry 74, no. 8 (2021): 1272–83. http://dx.doi.org/10.1080/00958972.2021.1897980.

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Roopa, H. R., J. Saravanan, S. Mohan, and Rekha Parmesh. "Synthesis, Characterization and Anti-Inflammatory Activity of Some Schiff bases of 4-Amino-5,6-Dimethyl thieno [2,3-d] Pyrimidines." Asian Journal of Research in Chemistry 8, no. 3 (2015): 213. http://dx.doi.org/10.5958/0974-4150.2015.00038.3.

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Senthil Kumar, Raju, Sundhararajan Naveena, Sekar Praveen, and Nagalingam Yogadharshini. "Therapeutic aspects of biologically potent vanillin derivatives: A critical review." Journal of Drug Delivery and Therapeutics 13, no. 7 (2023): 177–89. http://dx.doi.org/10.22270/jddt.v13i7.6159.

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4-hydroxy 3-methoxy benzaldehyde (Vanillin) is an aromatic phenolic aldehyde with unique chemical properties and pharmacological impact. Because of its potent nature, it acts as a lead for drug discovery and development techniques. Heterocyclic compounds with vanillin moiety were efficacious and thrive against many emerging infectious diseases, which can also lead to develop numerous fused heterocyclic vanillin derivatives and various heterocyclic compounds such as pyrimidines, quinoxalines, imidazoles or thiazoles. Greener-mediated synthesis is a sustained chemical reaction used to synthesize

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41

Hafez, Hend N., Abdulrahman G. Alshammari, and Abdel-Rhman B. A. El-Gazzar. "Facile heterocyclic synthesis and antimicrobial activity of polysubstituted and condensed pyrazolopyranopyrimidine and pyrazolopyranotriazine derivatives." Acta Pharmaceutica 65, no. 4 (2015): 399–412. http://dx.doi.org/10.1515/acph-2015-0037.

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Abstract Reaction of 6-amino-3-methyl-4-(substituted phenyl)-1,4- dihydropyrano[2,3-c]pyrazole-5-carbonitrile (1) with triethylorthoformate followed by treatment with hydrazine hydrate, formic acid, acetic acid, phenylisocyanate, ammonium thiocyanate and formamide afforded the corresponding pyranopyrimidine derivatives 2-6. Cyclocondensation of 1 with cyclohexanone afforded pyrazolopyranoquinoline 7. One-pot process of diazotation and de-diazochlorination of 1 afforded pyrazolopyranotriazine derivative 8, which upon treatment with secondary amines afforded 9 and 10a- c. Condensation of 2 with

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Pradhan, Rajesh, Milon Banik, David B. Cordes, Alexandra M. Z. Slawin, and Nitis Chandra Saha. "Synthesis, characterization, X-ray crystallography and DNA binding activities of Co(III) and Cu(II) complexes with a pyrimidine-based Schiff base ligand." Inorganica Chimica Acta 442 (March 2016): 70–80. http://dx.doi.org/10.1016/j.ica.2015.11.015.

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Alaa Abdulzahra, Mohammed, Ruaa Wassim Adam, and Hanaa Kadtem Egzar. "New polytetrazole synthesis and adsorption surface investigation based on sulfadiazine grafted polyimine." Himia, Fizika ta Tehnologia Poverhni 15, no. 3 (2024): 420–28. http://dx.doi.org/10.15407/hftp15.03.420.

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The present work concentrates on synthesizing and adsorption surface investigation of polytetrazole polymer (P-T) created from polyimine (P-S) grafted with sulfadiazine drug. The prepared polymer is synthesized by mechanochemical polycondensation reaction between dialdehyde aromatic compound and diamine aromatic compound by applying appropriate polar solvent and glacial acetic acid at (78 °C) as dependent on the polymerization reaction. The synthetic route to prepare tetrazole polymer (P-T) consists off multi chemical reaction process, firstly the synthesis of polyimine backbone (P-S) (4-(((4'

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Al-Fakeh, Maged S., Maha A. Alsikhan, and Jawza Sh Alnawmasi. "Physico-Chemical Study of Mn(II), Co(II), Cu(II), Cr(III), and Pd(II) Complexes with Schiff-Base and Aminopyrimidyl Derivatives and Anti-Cancer, Antioxidant, Antimicrobial Applications." Molecules 28, no. 6 (2023): 2555. http://dx.doi.org/10.3390/molecules28062555.

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A new class of biologically active mineral complexes was synthesized by reacting the following metal salts: MnCl2·4H2O, CoCl2·6H2O, CuCl2·2H2O, CrCl3·6H2O, and PdCl2 respectively with 2-amino-4,6-dimethyl pyrimidine (ADMPY) and Schiff’s base resulting from the condensation reaction between benzaldehyde with p-phenylenediamine and 2-hydroxy-1-naphthaldehyde as ligands have been synthesized and characterized on the basis of their CHN, thermal analysis, XRD, SEM and magnetic measurements along with their FT-IR and UV-vis spectra. The scanning electron microscope SEM measurements and the calculati

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Sankarganesh, M., J. Rajesh, G. G. Vinoth Kumar, et al. "Synthesis, spectral characterization, theoretical, antimicrobial, DNA interaction and in vitro anticancer studies of Cu(II) and Zn(II) complexes with pyrimidine-morpholine based Schiff base ligand." Journal of Saudi Chemical Society 22, no. 4 (2018): 416–26. http://dx.doi.org/10.1016/j.jscs.2017.08.007.

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Konar, Saugata, Samir Kanti Datta, Malay Dolai, et al. "Synthetic and structural investigations of Cd(II) complexes of tetradentate pyrimidine based Schiff base ligand: Insight through non-covalent interactions, TDDFT calculation and Hirshfeld surface analysis." Journal of Molecular Structure 1178 (February 2019): 682–91. http://dx.doi.org/10.1016/j.molstruc.2018.10.073.

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Narender, Malothu, Bhandaru Jaswanth S., Kulandaivelu Umasankar, et al. "Synthesis, in vitro antimycobacterial evaluation and docking studies of some new 5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3- d ]pyrimidin-4(3 H )-one schiff bases." Bioorganic & Medicinal Chemistry Letters 26, no. 3 (2016): 836–40. http://dx.doi.org/10.1016/j.bmcl.2015.12.083.

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Kumar, Momidi Bharath, Vanam Hariprasad, Shrinivas D. Joshi, et al. "Exploring the Antimicrobial Potential of Pyrimidine Linked Hydrazinyl Azole Derivatives: Insights from Biological Assays and Molecular Docking Studies." ChemistrySelect 8, no. 44 (2023). http://dx.doi.org/10.1002/slct.202301998.

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AbstractWe present a study on a new class of Schiff bases with pyrimidine linked hydrazinyl azole backbone. These compounds were synthesized using conventional and ultrasonication methods. Our design strategy incorporated three heteroaromatic azoles and various substituents on the pyrimidine scaffold to enhance antimicrobial properties. Antibacterial and antifungal screenings were conducted against specific pathogens, and molecular docking studies supported the results. The compounds exhibited significant antimicrobial activities, particularly against K. pneumoniae, surpassing the standard dru

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Kale, Vinod, Sainath Zangade, and Gangadhar Bhopalkar. "Synthesis, Spectroscopic Characterization and Study of Antibacterial Potency, Antioxidant Scavenging and in-vitro Anti-inflammatory Properties of Pyrimidine-based Schiff Bases." Current Bioactive Compounds 20 (July 3, 2024). http://dx.doi.org/10.2174/0115734072297463240614075754.

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Background:: As per the literature survey, the pyrimidine-based molecules display prominent antibacterial, anti-inflammatory, antioxidant, anticancer, analgesic, anticonvulsant, anti-tubercular and antimalarial properties. The biological relevance of pyrimidine-based pharmacophore structures encourages us to synthesize some novel imines derived from 2-amino pyrimidine and substituted benzaldehydes. Objective:: The present communication describes the synthesis of six imines 3a-f derived from 2- aminopyrimidine. The tri-potassium phosphate catalyst used in the current study optimizes the microwa

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Aktas Kamiloglu, Ayse, Tayfun Arslan, Askın Tekin, and Halit Kantekin. "Development of Pyrimidine‐Substituted Schiff Base and Their Axially Silicon Phthalocyanines as Inhibitors of Acetylcholinesterase and Butyrylcholinesterase for Alzheimer's Disease Therapy." Applied Organometallic Chemistry 39, no. 4 (2025). https://doi.org/10.1002/aoc.70113.

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ABSTRACTIn this study, axially substituted silicon (IV) phthalocyanine complexes containing pyrimidine‐substituted Schiff bases were synthesized and characterized. The Schiff bases (Pyr‐1 and Pyr‐2) were synthesized through a condensation reaction between pyrimidine derivatives and appropriate aldehydes, followed by their coordination with silicon (IV) to form the corresponding phthalocyanine complexes (Pyr‐1‐SiPc and Pyr‐2‐SiPc). The synthesized Schiff bases (Pyr‐1 and Pyr‐2) and silicon (IV) phthalocyanine derivatives (Pyr‐1‐SiPc and Pyr‐2‐SiPc) were subsequently tested in vivo for their inh

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