To see the other types of publications on this topic, follow the link: Schistocyte.

Journal articles on the topic 'Schistocyte'

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Schistocyte.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Diewchim, Chanida, Thanarat H. Chalidabhongse, Phandee Watanaboonyongcharoen, Sunisa Kongkiatkamon, and Panisinee Lawasut. "Artificial Intelligence RBC Recognition Program for Schistocyte Screening in Cytopenic Patients." Blood 142, Supplement 1 (2023): 5193. http://dx.doi.org/10.1182/blood-2023-174225.

Full text
Abstract:
Schistocyte identification is critical for the diagnosis of thrombotic microangiopathies (TMA). It is one of the most common consultative problems for hematologists. The count of schistocytes is poorly defined by automated complete blood count (CBC) machines. Furthermore, morphological evaluation using peripheral blood smear (PBS) staining is time-consuming and exhibits high variability among inexperienced internists. Our aim is to develop and assess the effectiveness of an in-house AI program for recognizing schistocytes. In phase I of this study, we developed an AI program using deep convolutional neural networks trained from schistocyte in blood smear pictures total 1066 pictures of 1066 patients and divided into training set and validation set. In the training set, 10,377 schistocytes were identified, resulting in an accuracy of 0.76977, precision of 0.78487, recall (sensitivity) of 0.97562, and F1-score (harmonic mean of precision and recall) of 0.86991. And in the validation set, 3,564 schistocytes were identified, resulting in an accuracy of 0.68462, precision of 0.73850, recall (sensitivity) of 0.90370, and F1-score of 0.81279. Then, during phase II, PBS from 133 patients from hematology consultation service due to anemia and/or thrombocytopenia were included and scanned by an automated, cell-locating image analysis system. The program's effectiveness was validated by comparing its detection of an increased in schistocytes from patient glass slides (>1%) with the conclusion from at least two out of three hematologists who conducted conventional microscopy readings. The Cohen's kappa agreement between the AI and hematologist readings was 0.583 (p < 0.001), representing moderate agreement. There were 58 slides with schistocytes >1% as determined by AI reading, while 34 PBSs were identified as showing a significant increase in schistocytes by hematologists. The sensitivity and specificity of significantly increased schistocyte detection were 97.1% and 74.7%, respectively. Blood smears with significantly increased schistocytes detected by the program had positive predictive and negative predictive values of 43.1% and 93.3%, respectively. Poikilocytosis from thalassemic red cells were the most misinterpreted. In sum, the developed AI program for schistocyte detection showed high sensitivity and acceptable specificity, especially in high prevalence thalassemia populations, indicating its potential to assist inexperienced clinicians and reduce the need for hematologist consultations. Adding more schistocyte samples could improve the program's specificity and efficiency of TMA diagnosis in the future.
APA, Harvard, Vancouver, ISO, and other styles
2

Hervent, Anne-Sophie, Maaike Godefroid, Barbara Cauwelier, Achiel Van Hoof, Johan Billiet, and Jan Emmerechts. "Evaluation of Schistocyte Analysis By a Novel Automated Digital Cell Morphology Application." Blood 124, no. 21 (2014): 4878. http://dx.doi.org/10.1182/blood.v124.21.4878.4878.

Full text
Abstract:
Abstract Introduction: The CellaVision Advanced Red Blood Cell (RBC) Software Application is a new software for advanced morphological analysis of RBC which automatically performs a preliminary characterization and grouping of RBC into 21 morphological categories, including schistocytes. Upon automated classification, the software offers the possibility of reclassification of RBC by the operator. The aim of this study was to evaluate the schistocyte analysis by the CellaVision Advanced RBC Application. Methods: Schistocyte counts were evaluated comparing the automated count on a CellaVisionTM DM96, both before and after reclassification, with the reference manual microscopic method. 76 samples of both hospitalized patients and healthy donors were analyzed. Results: Within-run, between-run and between-observer coefficients of variation were lower when counted with the CellaVision compared to the manual microscopic count. The very high sensitivity but rather poor specificity implicates the need for reclassification by the operator, following automated analysis. After reclassification, method comparison studies revealed good agreement with the manual microscopic method, with however slightly higher values of schistocytes for the automated analysis. Conclusion: The CellaVision Advanced RBC Software Application provides a sensitive, accurate and reproducible measurement of schistocytes in peripheral blood. Furthermore, it is an easy-to-use software and an excellent teaching tool that might contribute to standardization in the investigation of schistocyte-related conditions. Disclosures No relevant conflicts of interest to declare.
APA, Harvard, Vancouver, ISO, and other styles
3

Agarwal, Pooja, Rafiullah Khan, and Kristina Brannock. "Standardization of Schistocyte Identification and Quantitation for the Diagnosis of Thrombotic Microangiopathic Anemia at University of Cincinnati Medical Center." Blood 134, Supplement_1 (2019): 4796. http://dx.doi.org/10.1182/blood-2019-125174.

Full text
Abstract:
Background: Thrombotic microangiopathic anemia (TMA) is a hematological emergency that requires prompt review of a peripheral blood smear for the presence of schistocytes. Within our institution, we had concern for lack of consistency in identifying schistocytes, lack of consistency in reporting methods, possible variation in schistocyte quantitation due to microscope differences, and the threshold for which our laboratory had been reporting increased schistocytes. The objective of our quality improvement project was to implement published practice standards for morphological identification, quantitation, and reporting of schistocytes across different groups at the University of Cincinnati Medical Center (UCMC). Methods: The International Council for Standardization in Haematology (ICSH) recommendations for the identification, diagnostic value, and quantitation of schistocytes (Zini et. al. International Journal of Laboratory Hematology 2012) were reviewed prior to designing this project. We next conducted a survey of groups that were reviewing peripheral blood smears for schistocytes on a routine basis: medical technologists (n=9), pathology residents (n=10) and hematology-oncology fellows (n=13). The survey included questions about schistocytes, including desire for standardization and normal reference values, desire for pathologist instruction, and reporting patterns. One question included 8 images of various red cell morphologies, and participants were asked to select ones they would classify as schistocytes. The microscopes were compared for objective and field diameter measurements. Six (6) peripheral blood smears with previously reported schistocytes were re-reviewed. Schistocytes were identified per ICSH guidelines and counted as a percentage (%) of 1000 total red blood cells using a Miller optical disc and also as an average number per field for a total of 10 high power fields. The results were plotted on a linear X-Y axis graph (Fig 1) and compared to the ICSH guidelines (Fig 2) and the policy for reporting schistocytes in our laboratory. Results: Survey results showed that the majority of each group desired standardization, normal reference values, and pathologist instruction. For reporting of schistocytes, residents answered present/absent (50%) or average per high power field (HPF) (50%), whereas 92% of fellows answered average per HPF. No participants reported a percentage of 1000 red blood cells, the current ICSH recommendation. For the morphological identification, 50% of residents, 62% of fellows and 67% of technologists correctly identified keratocytes as schistocytes. Fifteen (15%) of fellows misidentified bite cells as schistocytes, whereas one fellow (8%) and one technologist (11%) misidentified acanthocytes as schistocytes. Only 70% of technologists correctly identified helmet cells as schistocytes, whereas all residents and fellows chose them correctly. Almost all participants failed to recognize microspherocytes as schistocytes. The microscopes all showed the same objective and field diameter measurements. The schistocyte percentage plotted versus the number of schistocytes per HPF showed a 0.99% correlation co-efficient (R=0.99%) (Fig 1). The results were compared to the ICSH threshold of 1%, above which the ICSH reports is a robust morphologic indicator for the diagnosis of TMA (Fig 2), and to the current reporting policy at UCMC. Two (2) schistocytes per HPF correlated with 1% schistocytes on the linear plot. At UCMC, policy had been to report 2-8 schistocytes per HPF as present and >8 per HPF as increased. These findings indicated that the threshold for reporting increased schistocytes should be lowered from >8 per HPF to >2 per HPF. The above data were reviewed with each survey group. A process was also initiated to change the laboratory schistocyte reporting policy. Conclusion: All survey groups needed and desired education on schistocyte identification and reporting per ICSH guidelines. All microscopes showed the same measurements and were therefore expected to produce the same quantitation results. Schistocyte percentage correlated with the number of schistocytes per HPF. By implementing the ICSH guidelines, we aimed to decrease inter-observer bias and to standardize the quantitation and reporting of schistocytes at UCMC, thereby assisting in timely and accurate diagnosis of thrombotic microangiopathic anemia. Disclosures No relevant conflicts of interest to declare.
APA, Harvard, Vancouver, ISO, and other styles
4

Khan, Mohammad Monirujjaman, Tahia Tazin, and Tabia Hossain. "An Automatic Blood Cell Separation Machine with Disease Detection System: Perspective in Bangladesh." Proceedings 67, no. 1 (2020): 9. http://dx.doi.org/10.3390/asec2020-07547.

Full text
Abstract:
Blood is a liquid that transports oxygen and supplements to cells and diverts carbon dioxide and other byproducts. Red blood cells principally carry oxygen and gather carbon dioxide using hemoglobin. Hereditary disease of the blood comprises hemoglobinopathies, which is a significant common health issue in Bangladesh. Sickle cell disorder alludes to the gathering of hereditary issues described by the presence of sickle hemoglobin, sickliness, schistocytes, intense and ongoing tissue injury and blockage of the bloodstream by anomalously formed red cells. Schistocytes are additionally a critical marker of a perilous condition affecting a human patient. In the cutting-edge setting, only the most modern computerized cell counters flag their administrators if a schistocyte is identified and few of them can provide a schistocyte tally. By analyzing these issues, in this paper, we propose to create an automatic system that will allow blood cells to be separated very quickly, and with this, blood diseases can be also identified.
APA, Harvard, Vancouver, ISO, and other styles
5

Schapkaitz, Elise, and Michael Halefom Mezgebe. "The Clinical Significance of Schistocytes: A Prospective Evaluation of the International Council for Standardization in Hematology Schistocyte Guidelines." Turkish Journal of Hematology 34, no. 1 (2017): 59–63. http://dx.doi.org/10.4274/tjh.2016.0359.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Patel, Vipul R., Jatinder Khokhar, Hemant S. Murthy, and Albert S. Braverman. "Burr Red Blood Cells (BC) In Patients with Disseminated Intravascular Coagulation (DIC)." Blood 116, no. 21 (2010): 5141. http://dx.doi.org/10.1182/blood.v116.21.5141.5141.

Full text
Abstract:
Abstract Abstract 5141 Burr red blood cells (BC) in patients with disseminated intravascular coagulation (DIC). Background: Angiopathic hemolysis with schistocytes occurs in a minority of DIC patients. Burr cells (BC), are morphologically homogeneous, with a serrated membrane resembling that of red cells (RBC) in a hypertonic medium. They are associated with acute renal insufficiency, and have been observed in DIC. Methods: Criteria for patient inclusion were sepsis, often with multi-organ failure and hypotension. Of the 39 patients studied, 20 had DIC, based on platelet counts <100,000, and an International Society of Hemostasis and Thrombosis score of ≥5, derived from D-dimer or fibrin split product levels, prothrombin time elevations, and fibrinogen levels. The percentages of BC and schistocytes were determined by 1000 RBC counts, without knowledge of data concerning DIC. Patients' [Hb]'s, serum creatinine and blood urea nitrogen (BUN), were recorded. Results: Five of the 20 DIC patients succumbed to their acute illness, while 15 recovered without developing renal insufficiency. The BC%'s of the 20 DIC patients ranged from 0–80%, with a median of 18% and a mean of 27%; in the 19 patients without DIC the range was 0–45%, the median 6.4% and the mean 11% (p=0.046). The schistocyte percentages in patients with and without DIC ranged from 0.20–17, and 0–78; the respective medians and means were 1.1% and 1.0%, and 3.0–5.8%. The median and mean [Hb]'s of the patients with and without DIC were 9.3 and 11, and 9.6 and 10.3, respectively. BC% did not correlate with the [Hb]. The median creatinine levels of patients with and without DIC were 0.92 and 0.93 mg/dl, though the DIC patients' BUN's were higher (medians 31 vs 15). The BC% correlated with neither the BUN nor the BUN/creatinine ratio. The median and mean serum sodium levels in patients with and without DIC were 137. Conclusion: BC's are significantly more frequent in septic patients with DIC than in those without it. BC% did not correlate with anemia, implying that BC do not cause significant hemolysis, though there was a trend to lower [Hb] in the DIC patients. BC% was much higher than that of schistocytes in both groups, and schistocyte percentages did not correlate with DIC or BC%. Because of the DIC patients' higher BUN's and BUN/creatinine ratio's, we cannot exclude a role for the factors, which caused pre-renal azotemia in BC formation. BC formation may prove to be a criterion for DIC. Disclosures: No relevant conflicts of interest to declare.
APA, Harvard, Vancouver, ISO, and other styles
7

Lesesve, J. F., H. El Adssi, J. Watine, W. Oosterhuis, and F. Régnier. "Evaluation of ICSH schistocyte measurement guidelines in France." International Journal of Laboratory Hematology 35, no. 6 (2013): 601–7. http://dx.doi.org/10.1111/ijlh.12092.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Falsetti, Lorenzo, Mattia Sampaolesi, Francesca Riccomi, and Cinzia Nitti. "Adalimumab as a potential cause of drug-induced thrombocytopaenic microangiopathy." BMJ Case Reports 13, no. 3 (2020): e233526. http://dx.doi.org/10.1136/bcr-2019-233526.

Full text
Abstract:
We report the case of a 63-year-old male patient admitted to our emergency department for dyspnoea, peripheral oedema, severe diarrhoea and asthenia. History revealed Crohn’s disease (CD) submitted to several intestinal surgical resections in the previous years. He recently started a treatment with adalimumab for the control of CD. Laboratory tests at the admission revealed severe haemolytic anaemia and thrombocytopaenia. Haptoglobin levels were low, schistocyte count was markedly increased. In the suspect of thrombotic microangiopathy, he was admitted to our internal medicine department where we urgently started plasma exchange (PEX). We observed normal ADAMTS-13 activity in absence of Shiga toxin or enterotoxic Escherichiacoli at stool tests. Despite a diagnosis of atypical haemolytic–uraemic syndrome, we observed full platelet count recovery and schistocytes normalisation after the fourth PEX. We then put a diagnosis of adalimumab-induced thrombocytopaenic microangiopathy. Adalimumab was withdrawn. We did not observe relapses in the following 3 months.
APA, Harvard, Vancouver, ISO, and other styles
9

Ahmed, Mashrafi, and Ashok R. Patel. "Evaluation of Normal Reference Range of Schistocytes and Burr Cells in Healthy Adults." Blood 126, no. 23 (2015): 4540. http://dx.doi.org/10.1182/blood.v126.23.4540.4540.

Full text
Abstract:
Abstract Introduction: Schistocytes are split red blood cells that indicate microangiopathic hemolytic anemia. Their presence in a peripheral smear is the hallmark for diagnosing thrombotic thrombocytopenic purpura (TTP). Schistocytes may also be seen in healthy individuals and in patients with other diseases such as preeclampsia, eclampsia, chronic renal failure, solid organ or bone marrow transplantation, and diabetic microangiopathy as well as in patients with a prosthetic heart valve. Burr cells (echinocytes) are red blood cells with short, evenly spaced spicules and preserved central pallor that is usually artifactual (observed in uremia and liver disease). There has been no clear definition of a reference range for schistocytes or burr cells in normal individuals and among patients with various diseases. A previous study by Burns et al. included only 40 normal individuals to analyze the presence of schistocytes. In this study, we analyzed peripheral smears of 148 normal individuals to detect the normal reference range of schistocytes and burr cells in healthy adults and also attempted to determine the number of RBCs that need to be evaluated to consider the evaluation satisfactory. Method: We evaluated 148 peripheral blood smears of blood samples obtained from apparently healthy ambulatory adults (>18 years of age) with normal hemoglobin to determine the presence of schistocytes and burr cells. Result: Schistocytes were observed in approximately 78% of normal individuals with a mean of 0.15% of all RBCs. This finding is different from that of a previous study by Burns et al. (3) where schistocytes were observed in 58% of normal individual. Burr cell were observed in 77% of normal individual with a mean of 0.051% of all RBCs. Table 1. Analysis of collected data for schistocytes RBC Count Mean Std. Deviation 95% CI (predicted values) 1000 1.73 1.26 1.51-1.93 2000 1.92 1.56 1.74-2.14 3000 1.59 1.26 1.39-1.80 4000 1.17 0.97 0.97-1.37 5000 1.26 1.10 1.06-1.46 Total 1.54 1.28 Table 2. Analysis of collected data for burr cells RBC Count Mean Std. Deviation 95% CI (predicted values) 1000 0.86 0.87 0.75-0.98 2000 0.34 0.50 0.23-0.45 3000 0.59 0.79 0.48-0.70 4000 0.32 0.69 0.20-0.43 5000 0.44 0.56 0.33-0.553 Total 0.51 0.72 Discussion: TTP is an acute hematologic disorder involving different organ systems. The main pathophysiology of the disease is microvascular thrombosis due to increased platelet aggregation resulting in mechanical damage to erythrocytes. The diagnosis of TTP is predominantly based on characteristic clinical and laboratory findings. Therefore, observing schistocytes on peripheral smear is one of the key findings in the diagnostic process. A schistocyte is a fragmented erythrocyte characteristic of hemolysis or cell fragmentation. There is no clear definition of its appearance, shape, or size. Schistocyte recognition in the peripheral smear is largely based on clinician experience. Its mere presence is not exclusive of any pathological conditions only because it can also be observed in peripheral smears of a healthy patient. In the study by Burns et al., schistocytes were found in all patients with a mechanical heart valve, in 93% of patients with chronic renal failure, and in 58% of normal individuals. This finding is significantly different from that of our study where schistocytes were present in 87% of normal individuals. The reason of such a difference may be the extensive evaluation of each peripheral smear with the analysis of at least 5000 cells on each slide. Burr cells, also known as echinocytes, have a speculated border over the entire cell surface. Burr cells are commonly found in both end-stage renal disease and liver disease. In our study, Burr cells were found in 80% of healthy individuals although the numbers of cells are very small. One of the key findings in our analysis is determining the successful evaluation of peripheral smears for these two morphological variants of RBCs. Our data show that there is no significant change in the variation of the presence of schistocytes if 3000 erythrocytes are evaluated in a peripheral smear. For Burr cells, the analysis of 1000 erythrocytes in a high-power field appears sufficient. However, the drawback is that it is extremely time consuming to manually count such high numbers of RBCs and thus, the chance of an error is quite high. Disclosures No relevant conflicts of interest to declare.
APA, Harvard, Vancouver, ISO, and other styles
10

Woodall, Julia Lins Arrighi, Meredith Ellen Fay, Jordan Ciciliano, Reza Abbaspour, Muhannad S. Bakir, and Wilbur A. Lam. "Real-Time Visualization of Shear-Dependent Erythrocyte Deformation into Schistocytes Using Single Micron Microfluidics." Blood 132, Supplement 1 (2018): 1030. http://dx.doi.org/10.1182/blood-2018-99-120113.

Full text
Abstract:
Abstract Background: The vasculature consists of a dynamic mechanical microenvironment whereby blood cells experience a wide variety of shear stresses and pressures (Wootton et al., Annu. Rev. Biomed. Eng., 1999).This is enhanced in the context of prothrombotic conditions, especially in the microvasculature, during which the introduction of a pathologic fibrin matrix can affect both the fluidic microenvironment and create physical obstacles in the blood stream. These forces act as erythocytic biophysical cues and have been found to affect ATP release and the deformation into abnormal cell morphologies (Gov et al., Biophysical Journal, 2005). These deformations affect both cell form and function in turbulent conditions such as heart valves, thrombotic microangiopathies, and prothrombotic disorders like disseminated intravascular coagulation (Levi et al., N Engl J Med, 1999). The presence of mechanically damaged erythrocytes like schistocytes in blood smears are used to detect these disorders, however, the underlying biophysical mechanisms of how they are formed remains largely unknown (Zini, et al., Int. J. Lab. Hematol., 2012). To that end, we developed microfluidic devices with single-micron sizescales and "canal-like" features of varying lengths to recreate the mechanical microenvironment in biophysical constrictions that occur in microvascular thrombotic disorders associated with schistocyte formation. With these specialized microfluidics, we previously observed the fragmentation of erythrocytes in real-time and found that the extent of erythrocyte damage was dependent on the length of the constricting canal, which affects the pressure differential and transit time (Ciciliano et al., Lab on a Chip, 2017). Here, we hypothesize that increasing shear rate in these microchannel canals will increase the formation of altered erythrocytes including schistocytes. Methods: Our microfluidic devices are fabricated via electron beam lithography and consist of microcanals with a 2 µm width, a 3 µm height, and lengths varying from 5 µm to 45 µm, simulating the physical dimension of in vivo microvascular constrictions (Figure 1A). A PBS solution containing 20% erythrocytes by volume was perfused through the microfluidic devices at shear rates of 30,000 to 120,000 dyne/cm2 at the microcanals. Erythrocyte deformation was observed in real-time using high speed video microscopy. To our knowledge, there are no other systems allowing for visual analysis of erythrocyte fragmentation through single micron microfluidic constrictions. Further, this microfluidic platform decouples biochemical cues from the biophysical cues being studied that lead to deformation of erythrocytes in real-time. Results: We show that increasing shear rate at lower microcanal lengths of 5 µm, 10 µm and 15 µm resulted in little or no erythrocyte fragmentation. However, increasing shear rates at microcanal lengths of 20 µm resulted in reversible burr cell formation at low shear rates, and then increased fragmentation to potential schistocyte and ghost cell formation at the highest shear rates (Figure 1B). The percentage of non-reversible erythrocyte deformation continued to rise with increased shear rate at microcanal lengths greater than 25 µm (Figure 1C). Conclusion: Our results suggest that shear rate and constriction time work synergistically to affect plastic erythrocyte deformation into a variety of abnormal morphologies typical in thrombotic microangiopathic disorders. These results align with literature findings in larger experimental systems, where increased hemolysis has been observed through increasing shear stress (Leverett et al., Biophys J., 1972) and increasing pressure when coupled with high shear rates (Yasuda et al., ASAIO Journal, 2001). We plan to further characterize the formation of schistocytes by examining the interactions between the biophysical parameter space and the biochemical parameter space in microfluidic systems. By studying how variables such as shear, compression, fibrin density, and platelet concentration affect erythrocyte fragmentation, we will find the optimal conditions for schistocyte formation. These findings will lead to an improved understanding of microangiopathic pathological processes and aid in developing diagnostic assays in the future. Disclosures No relevant conflicts of interest to declare.
APA, Harvard, Vancouver, ISO, and other styles
11

LESESVE, J. F., F. ALLA, F. DUGUÉ, et al. "Evaluation of schistocyte monitoring after haematopoietic stem cell transplantation." International Journal of Laboratory Hematology 33, no. 4 (2011): 343–56. http://dx.doi.org/10.1111/j.1751-553x.2010.01292.x.

Full text
APA, Harvard, Vancouver, ISO, and other styles
12

Wendt, George R., Michael L. Reese, and James J. Collins. "SchistoCyte Atlas: A Single-Cell Transcriptome Resource for Adult Schistosomes." Trends in Parasitology 37, no. 7 (2021): 585–87. http://dx.doi.org/10.1016/j.pt.2021.04.010.

Full text
APA, Harvard, Vancouver, ISO, and other styles
13

Maenhout, T. M., and L. Marcelis. "Automated microscopy could decrease intra- and interobserver variation in microscopic schistocyte quantitation." International Journal of Laboratory Hematology 36, no. 6 (2014): e91-e93. http://dx.doi.org/10.1111/ijlh.12217.

Full text
APA, Harvard, Vancouver, ISO, and other styles
14

Hervent, A. S., M. Godefroid, B. Cauwelier, J. Billiet, and J. Emmerechts. "Evaluation of schistocyte analysis by a novel automated digital cell morphology application." International Journal of Laboratory Hematology 37, no. 5 (2015): 588–96. http://dx.doi.org/10.1111/ijlh.12363.

Full text
APA, Harvard, Vancouver, ISO, and other styles
15

Lesesve, Jean-François, Sylvain Salignac, François Alla, et al. "Comparative Evaluation of Schistocyte Counting by an Automated Method and by Microscopic Determination." American Journal of Clinical Pathology 121, no. 5 (2004): 739–45. http://dx.doi.org/10.1309/my7077989kwdyp88.

Full text
APA, Harvard, Vancouver, ISO, and other styles
16

Širáková, Andrea, Petr Toušek, František Bednář, et al. "Intravascular haemolysis after transcatheter aortic valve implantation with self-expandable prosthesis: incidence, severity, and impact on long-term mortality." European Heart Journal Supplements 22, Supplement_F (2020): F44—F50. http://dx.doi.org/10.1093/eurheartj/suaa098.

Full text
Abstract:
Abstract We aimed to determine the incidence, severity, and long-term impact of intravascular haemolysis after self-expanding transcatheter aortic valve implantation (TAVI). We believe this should be evaluated before extending the indications of TAVI to younger low-risk patients. Prospective, academic, single centre study of 94 consecutive patients treated with supra-annular self-expandable TAVI prosthesis between April 2009 and January 2014. Haemolysis at 1-year post-TAVI was defined per the published criteria based on levels of haemoglobin, reticulocyte and schistocyte count, lactate dehydrogenase (LDH), and haptoglobin. All patients had long-term clinical follow-up (6 years). The incidence of haemolysis at 1-year follow-up varied between 9% and 28%, based on different haemolysis definitions. Haemolysis was mild in all cases, no patient had markedly increased LDH levels. The presence of moderate/severe paravalvular aortic regurgitation was associated with haemolysis (7.7% vs. 23.1%, P = 0.044) and aortic valve area post-TAVI did not differ between groups with or without haemolysis (1.01 vs. 0.92 cm2/m2, P = 0.23) (definition including schistocyte count). The presence of haemolysis did not have any impact on patient prognosis after 6 years with log-rank test P = 0.80. Intravascular haemolysis after TAVI with self-expandable prosthesis is present in 9–28% of patients depending on the definition of haemolysis. The presence of haemolysis is associated with moderate/severe paravalvular aortic regurgitation but not with post-TAVI aortic valve area. Haemolysis is mild with no impact on prognosis.
APA, Harvard, Vancouver, ISO, and other styles
17

Noutsos, Tina, Alexandra Y. Laidman, Lesley Survela, et al. "An evaluation of existing manual blood film schistocyte quantitation guidelines and a new proposed method." Pathology 53, no. 6 (2021): 746–52. http://dx.doi.org/10.1016/j.pathol.2021.01.008.

Full text
APA, Harvard, Vancouver, ISO, and other styles
18

Huh, H. J., J. W. Chung, and S. L. Chae. "Microscopic schistocyte determination according to International Council for Standardization in Hematology recommendations in various diseases." International Journal of Laboratory Hematology 35, no. 5 (2013): 542–47. http://dx.doi.org/10.1111/ijlh.12059.

Full text
APA, Harvard, Vancouver, ISO, and other styles
19

O'Brien, Timothy E., Lynda Bowman, Augustine Hong, and Krishna Goparaju. "Quantification of Schistocytes from the Peripheral Blood Smear in Thrombotic Thrombocytopenic Purpura (TTP) Compared to Non-TTP Thrombocytopenic Hospitalized Patients." Blood 132, Supplement 1 (2018): 4983. http://dx.doi.org/10.1182/blood-2018-99-114159.

Full text
Abstract:
Abstract Introduction The diagnosis of TTP requires thrombocytopenia without an underlying cause and microangiopathic hemolytic anemia (MAHA)1. TTP is usually confirmed with a low ADAMTS level. However, the turnaround time for an ADAMTS level is several days and treatment for this rare disease cannot be delayed, since it is uniformly fatal if left untreated but highly responsive to plasma exchange therapy. A rapid diagnosis is required and still must be made on clinical findings and peripheral smear morphology. The degree of MAHA that is seen with TTP, though, has not been well defined, or correlated with ADAMTS results. Automated fragmented red cell analyzers are not yet widely available or accepted, so the determination of MAHA still relies on manual smear reviews. Presenting smears from pts with TTP over a 1 ½ year period were reviewed, with manual counting of schistocytes, and were compared to smears from in-patient non-TTP cases of thrombocytopenia where hematology was consulted to rule out TTP. Methods 29 cases were identified and peripheral smears from date of presentation were reviewed, initially by a hematologist and experienced special hematology technician, then by 2 medicine residents after they were given a 1 hour tutorial on smear interpretation. All smear reviewers were instructed on schistocyte identification as defined by the International Council for Standardization in Hematology (ICSH)2. The number of schistocytes per 1000 red cells was counted at 1000 power magnification. The blood smears were coded/de-identified and then read "blindly" by the 4 observers. Degree of agreement between the 1st 2 observers was measured (using Pearson correlation coefficient), as was the their average as compared to the average #schistocytes counted between the 2 med residents. Time taken to review smears was also measured. Results Ave age 54 (19-83); 59% female, 41% male; 62% Caucasian; 35% AA; 3% Hispanic. 9 had TTP and 20 did not. All cases of TTP had a low ADAMTS level (med <3%, range <3-13%) and all but one had a +inhibitor (one had congenital TTP, confirmed by ADAMTS mutation analysis). The non-TTP cases included sepsis (8/20), DIC (3/20), metastatic cancer (2/20), scleroderma crisis (2/20) and single cases of HIT, EtOH, gestational, MPN/MDS and unknown causes for thrombocytopenia. For TTP cases: med plt count was 22k (4-52k); LDH 760 (309-1175); hgb 9.4 (7.1-10.9); creat 1.59mg/dL (0.6-4.85). For non-TTP cases: med plt count was 44k (3-126k); LDH 300 (155-1111); hgb 8.1 (5.9-14.7); creat 1.36mg/dL (0.9-9.1). 3 non-TTP pts had ADAMTS levels sent (med= 69%, 57-100%). The med #schistocytes in TTP cases was 6% (ave 6.3, 1.85-11.95%) compared to 0.625% (ave 1.52%, 0.25-7.5%) in the non-TTP group (p= 0.00002). The R-coefficient for the 1st 2 observers was 0.93 (95% CI 0.85-0.96) and for their average compared to the 2 medicine residents it was 0.82. The average time to read smears overall was 10.5 minutes. Conclusions: This retrospective study showed that manual quantification of schistocytes is feasible, may be done in a timely fashion and with excellent interobserver reproducibility. All pts had some degree of MAHA but the TTP cases, not surprisingly, had a significantly higher percentage of schistocytes/1000 RBCs than non-TTP thrombocytopenic in-pt consult cases (6% vs 0.625%, respectively, p= 0.00002). All cases of low ADAMTS, positive inhibitor confirmed TTP had >2.5% schistocytes, compared to 4/20 non-TTP cases. A larger cohort of acquired TTP should be studied to determine if there is a cut-off % schistocytes which, in the appropriate clinical setting, should warrant urgent plasma exchange while waiting for ADAMTS levels to return. 1George JN and Al-Noun ZL. Diagnostic and therapeutic challenges in the TTP and HUS syndromes. ASH Education Book. 2012, p. 604-609. 2Zini G et al. ICSH recommendations for identification, diagnostic value, and quantitation of schistocytes. International J of Lab Hematology. 2011; 34: 107-116. Disclosures No relevant conflicts of interest to declare.
APA, Harvard, Vancouver, ISO, and other styles
20

Ikegame, Akishige, Yusuke Inoue, Makoto Hata, et al. "The ADVIA2120i parameter Revised %MICRO is a surrogate marker of schistocyte formation after hematopoietic stem cell transplantation." Journal of Medical Investigation 67, no. 3.4 (2020): 250–54. http://dx.doi.org/10.2152/jmi.67.250.

Full text
APA, Harvard, Vancouver, ISO, and other styles
21

Bahr, Timothy M., Allison J. Judkins, Robert D. Christensen, et al. "Neonates with suspected microangiopathic disorders: performance of standard manual schistocyte enumeration vs. the automated fragmented red cell count." Journal of Perinatology 39, no. 11 (2019): 1555–61. http://dx.doi.org/10.1038/s41372-019-0482-y.

Full text
APA, Harvard, Vancouver, ISO, and other styles
22

Demagny, Julien, Camille Roussel, Maïlys Le Guyader, et al. "Combining imaging flow cytometry and machine learning for high-throughput schistocyte quantification: A SVM classifier development and external validation cohort." eBioMedicine 83 (September 2022): 104209. http://dx.doi.org/10.1016/j.ebiom.2022.104209.

Full text
APA, Harvard, Vancouver, ISO, and other styles
23

Thulasimani, J., P. Sanjai, A. Santhakumar, and T. Santhosh. "Detection of poikilocytosis cells in anemia using (ANN) & embedded systems." i-manager’s Journal on Electronics Engineering 14, no. 4 (2024): 20. http://dx.doi.org/10.26634/jele.14.4.20829.

Full text
Abstract:
In the bloodstream, erythrocytes stand as vital carriers of oxygen and carbon dioxide, facilitated by the presence of hemoglobin within their structures. However, deviations in erythrocyte size can lead to the formation of Poikilocyte cells, a characteristic feature of conditions like Iron Deficiency Anemia. Variants of Poikilocytoses, such as Degmacyte, Dacrocyte, Schistocyte, and Elliptocyte, denote distinct alterations in erythrocyte morphology, often associated with diminished iron levels crucial for haemoglobin synthesis. In a recent study, the differentiation between normal RBCs and Poikilocyte cells has been addressed through the application of Artificial Neural Network (ANN) algorithms, leveraging extracted features from digital images of blood smears. This approach offers a more precise means of identifying blood disorders compared to traditional visual inspection, utilizing image analysis techniques to detect deviations in color, size, and statistical parameters. The methodology involves a series of computational steps including preprocessing, segmentation, morphological operations, feature extraction, and classification, all executed within the Matlab environment. Furthermore, to enhance diagnostic capabilities, the system integrates glucose level measurement alongside erythrocyte analysis, transmitting data to a controller which relays results via GSM signal as SMS and LCD display. This comprehensive approach not only automates cell identification and classification but also ensures efficient and accurate analysis, including the automated separation of overlapped cells.
APA, Harvard, Vancouver, ISO, and other styles
24

Lesesve, Jean-François, Odile Fenneteau, and Gina Zini. "Schistocytes." Transfusion 54, no. 6 (2014): 1459. http://dx.doi.org/10.1111/trf.12523.

Full text
APA, Harvard, Vancouver, ISO, and other styles
25

Oliver, J. W., R. S. Akins, M. K. Bibens, and D. M. Dunn. "Pneumococcal Induced T-activation with Resultant Thrombotic Microangiopathy." Clinical Medicine Insights: Pathology 3 (January 2010): CPath.S670. http://dx.doi.org/10.4137/cpath.s670.

Full text
Abstract:
Thrombotic microangiopathies are disorders resulting from platelet thromboses forming in the microvasculature with resultant schistocyte forms. Hemolytic uremic syndrome (HUS) is a microangiopathic hemolytic anemia often complicated by acute renal failure in children. HUS is typically caused by bacterial infection, most commonly enterohemorrhagic Escherichia coli. Neuraminidase-producing organisms, such as Streptococcus pneumoniae have also been reported as potential etiologies. The pathogenesis in these cases involves cleavage of sialic acid residues from the surfaces of erythrocytes, platelets, and glomerular capillary endothelial cells, exposing the Thomsen-Friedenreich antigen, a process known as T-activation. We describe a 2-year-old girl who presented with pneumococcal pneumonia and sepsis ultimately resulting in a thrombotic microangiopathy with acute renal failure, most consistent with HUS. The patient's direct antiglobulin test was positive. Polyagglutination was observed with human adult serum, but not with umbilical cord serum. Her red blood cells (RBCs) were reactive against peanut and soybean lectins, but not Salvia sclarea or Salvia horminum lectins. These findings are consistent with T-activation. Clinicians should be cognizant of the possibility of T-activation with resultant HUS in patients infected with neuraminidase-producing bacteria. Such patients may be difficult to identify using monoclonal typing antisera, as these typically do not have anti-T antibodies. Whether such patients are at risk for transfusion-associated hemolysis is debatable.
APA, Harvard, Vancouver, ISO, and other styles
26

Doležel, Zdeněk, Veronika Fiamoli, and Jan Papež. "Znáte schistocyty?" Pediatrie pro praxi 19, no. 6 (2018): 363. http://dx.doi.org/10.36290/ped.2018.074.

Full text
APA, Harvard, Vancouver, ISO, and other styles
27

Gonçalves, Catarina A., Maria Teresa Furtado, Patrícia A. Domingues, Ana D. Piedade, and Ana Natario. "Deceiving Schistocytes." Journal of the American Society of Nephrology 32, no. 10S (2021): 587. http://dx.doi.org/10.1681/asn.20213210s1587a.

Full text
APA, Harvard, Vancouver, ISO, and other styles
28

Sweeney, Joseph, Mohammad Barouqa, Gregory Krause, Jesus Gonzalez Lugo, Shafia Rahman, and Morayma Reyes. "Low ADAMTS13 Activity Correlates with Increased Mortality in COVID-19 Patients." American Journal of Clinical Pathology 156, Supplement_1 (2021): S6—S7. http://dx.doi.org/10.1093/ajcp/aqab189.011.

Full text
Abstract:
Abstract Systemic inflammation and coagulopathy are characteristic hallmarks of COVID19. “COVID coagulopathy” manifests mainly as a prothrombotic state affecting both large and small blood vessels, and presenting as arterial, venous, and microangiopathic thrombotic events with von Willebrand factor (VWF) and soluble thrombomodulin increased in hospitalized patients. The causes of coagulopathy are poorly understood. Aim: To investigate the relationship between von Willebrand factor (VWF) biomarkers, intravascular hemolysis, coagulation, and organ damage in COVID19 patients and to study their association with disease severity and mortality. Methods: 181 hospitalized adult COVID19 patients were randomly selected with a balanced distribution of survivors and non-survivors during the period of March 26th 2020 to May 5th 2020. The medical records and laboratory values were reviewed. Statistical analysis was performed using R studio V.3.6.2. Results: Patients who died (n=90) had significantly lower ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) activity, elevated lactate dehydrogenase levels, increased schistocyte/RBC fragment counts, and elevated VWF antigen and activity levels compared to patients discharged alive (n=91). In 31 patients, we measured several of these biomarkers on two or more occasions. The trending of ADAMTS13 activity illustrated that it is not steady throughout the hospitalization course. ADAMTS13 activity levels tended to improve and/or reach normal levels in patients that survived, yet ADAMTS13 activity levels worsened in most patients that died. Likewise, the VWF antigen and activity levels tended to decrease in patients that survived whereas tended to increase well above the normal range (2-3 folds) in patients that died. D-Dimer levels trended downwards in survivors, sometimes to levels less than 1 µg/ml, yet tended to increase in patients who died. Given the relationship between ADAMTS13 activity and mortality, we wanted to determine a cut-point of initial ADAMTS13 activity (within 72 hours from admission) to predict mortality. 102 patients in our cohort had an ADAMTS13 activity measurement within this timeframe. We determined that this optimal cut-point of initial ADAMTS13 activity was 43% using Youden’s J statistic. Only 30% of patients who had an ADAMTS13 activity level of less than 43% on admission survived, yet 60% of patients survived who had an ADAMTS13 activity level of greater than 43% on admission. Conclusions: COVID-19 may present with low ADAMTS13 activity in a subset of hospitalized patients. Presence of schistocytes/RBC fragment and elevated D-dimer levels on admission may warrant a work-up for ADAMTS13 activity and VWF antigen and activity levels. These findings indicate the need for future investigation to study the relationship between endothelial and coagulation activation and the efficacy of treatments aimed at prevention and/or amelioration of microangiopathy in COVID-19.
APA, Harvard, Vancouver, ISO, and other styles
29

El-Gamal, Rasha A., Mohamed A. Mekawy, Ayman M. Abd Elkader, Haitham M. Abdelbary, and Mary Z. Fayek. "Combined Immature Platelet Fraction and Schistocyte Count to Differentiate Pregnancy-Associated Thrombotic Thrombocytopenic Purpura from Severe Preeclampsia/Haemolysis, Elevated Liver Enzymes, and Low Platelet Syndrome (SPE/HELLP)." Indian Journal of Hematology and Blood Transfusion 36, no. 2 (2019): 316–23. http://dx.doi.org/10.1007/s12288-019-01200-y.

Full text
APA, Harvard, Vancouver, ISO, and other styles
30

Atkins, James N., and Hyman B. Muss. "Schistocytes in Erythroleukemia." American Journal of the Medical Sciences 289, no. 3 (1985): 110–13. http://dx.doi.org/10.1097/00000441-198503000-00004.

Full text
APA, Harvard, Vancouver, ISO, and other styles
31

Rosita, Betti, and Helvina Mustika. "HUBUNGAN TINGKAT TOKSISITAS LOGAM TIMBAL (Pb) DENGAN GAMBARAN SEDIAAN APUS DARAH PADA PEROKOK AKTIF." JURNAL KESEHATAN PERINTIS (Perintis's Health Journal) 6, no. 1 (2019): 14–20. http://dx.doi.org/10.33653/jkp.v6i1.216.

Full text
Abstract:
Based on the results of a survey conducted by the World Health Organization (WHO) in 2012, the number of active smokers in the world has reached more than 1 billion people. This number is expected to continue to increase given the high prevalence of world cigarette consumption rates, while in Indonesia it is found that almost every year the number of smokers is increasing. Cigarettes containing chemicals including carbon monoxide, nicotine, tar, ammonia, arsenic, cyanide and lead (Pb) The main effect is lead that is inhaled and enters the respiratory system will also circulate throughout the tissues and organs of the body. More than 90% of lead metal absorbed by blood binds to red blood cells and results in a disruption in the process of hemoglobin synthesis. The purpose of this study is to determine the level of lead metal toxicity with an overview of smear preparations in the blood of active smokers. The research method with simple random sampling, samples taken capillary blood and making blood smear preparations that were examined with a microscope while examining the metal in the urine using Atomic Absorption Spectrophotometer (AAS). The results of the study of lead content in urine of active smokers found that the high is 0.384 mg / dl and the low lead level is 0.002 mg / dl positive containing lead in the urine with the amount of lead content exceeding the threshold and from the results of the smear dosage found that normal or normociter cell size can be obtained normal or normochrome (1/3 of the center is pale) whereas abnormalities in the cell form are teardrop cells, ovalocytes, schistocyte, this is due to the effect of lead that disrupts health especially usually occurs in haemotopoetic systems (blood formation system)
APA, Harvard, Vancouver, ISO, and other styles
32

Lesesve, J. F., S. Salignac, and T. Lecompte. "Laboratory measurement of schistocytes." International Journal of Laboratory Hematology 29, no. 2 (2007): 149–51. http://dx.doi.org/10.1111/j.1751-553x.2006.00829.x.

Full text
APA, Harvard, Vancouver, ISO, and other styles
33

Bain, Barbara J. "Schistocytes in megaloblastic anemia." American Journal of Hematology 85, no. 8 (2010): 599. http://dx.doi.org/10.1002/ajh.21657.

Full text
APA, Harvard, Vancouver, ISO, and other styles
34

Reynolds, Samuel B., and William Tse. "Evaluating and Correcting Iron Deficit in Atypical Hemolytic Uremic Syndrome (HUS)." Blood 132, Supplement 1 (2018): 5002. http://dx.doi.org/10.1182/blood-2018-99-112353.

Full text
Abstract:
Abstract Introduction: Atypical hemolytic uremic syndrome (HUS), in the absence of Shiga toxin producing E. coli, is most often complement mediated and is associated with microangiopathic hemolytic anemia (MAHA). And while this association is well understood, it is less common to encounter concurrent pre-existing iron deficiency anemia. In such patients, apart from correcting anemia with supportive blood transfusions, the calculation and correction of iron deficit is a valuable but underutilized management strategy, and is highlighted in the presented case. Example case: A 33 year-old Hispanic female with no significant past medical history other than iron deficiency anemia with a baseline hemoglobin of 5.4 g/dL presented to the hospital for abnormal renal function seen on outside laboratory studies. She was found on admission to have a creatinine of 15.47, BUN of 94 (baselines unknown), LDH of 451, haptoglobin of 44, hemoglobin of 6.9 (MCV 87) and platelets of 107 x 10³/µL. Vital signs were stable. Peripheral smear revealed approximately 1 schistocyte/hpf. She complained of a recent but resolving upper respiratory infection and a 10 day history of new-onset blurry vision; she self-identified as a Jehovah's Witness. The patient was tentatively diagnosed with atypical HUS in light of MAHA, Cr >1.5, platelets>30 with only occasional schistocytes and no antecedent diarrheal illness. To definitely rule out pre-existing intrinsic renal disease and/or IgA nephropathy, however, the patient required a kidney biopsy, but was unable to undergo the procedure because of her anemia, thrombocytopenia and refusal to receive whole blood if needed. The patient's desired hemoglobin in order to undergo biopsy was set at 10 g/dL, and iron deficit was calculated as 677 mg. The patient was administered intravenous iron sucrose along accordingly along with epoetin, which resulted in gradual improvement in anemia during hospitalization. Decision to biopsy was deferred to her outpatient care provider. Discussion: Atypical HUS responds best to supportive care with blood transfusions and dialysis, if accompanying symptomatic uremia is present. Definitive therapy is with eculizumab. Patients who will not receive blood for religious purposes, however, present a challenge to providers in the acute setting of HUS, as gradual hemolysis can result in tissue hypoxia, hemodynamic instability and even death. Should patients have concurrent iron deficiency, however, even in the setting of active hemolysis, replacing iron can result in meaningful hemoglobin recovery. Iron deficit is calculated by the following equation: Body weight (in kg) x [target Hb - actual Hb] + depot iron (which is 500 mg if patient >35 kg). Iron deficit as a clinical tool is seldom discussed in the literature, with a particular paucity in studies pertaining to atypical HUS. One potential explanation for this absence is that atypical HUS is an already rare diagnosis, and is a disorder of peripheral red blood cell destruction rather than a disorder of decreased hemoglobin-to-oxygen binding, as is seen in iron deficiency. Regardless, the utility of iron replacement is evident in the presented case of atypical HUS, and should be explored further in larger scale retro- and prospective studies. Conclusions: While disease-directed therapy in atypical HUS (i.e. eculizumab) is required to effectively manage acute, complement-mediated hemolytic anemia and renal failure, correction of the calculated iron deficit in co-existing iron deficiency anemia, if present, can result in gradual but marked improvement in hemoglobin. Conversely, patients with atypical HUS who are actively hemolyzing with a normocytic anemia should still be evaluated for iron deficiency and undergo iron transfusions for any calculated deficit. Disclosures No relevant conflicts of interest to declare.
APA, Harvard, Vancouver, ISO, and other styles
35

Lesesve, Jean-François, Odile Crepin, Jean-Pascal Siest, François Régnier, and Stan Zeltner. "Evaluation of schistocytes measurement guidelines." Annales de biologie clinique 70, no. 5 (2012): 605–13. http://dx.doi.org/10.1684/abc.2012.0751.

Full text
APA, Harvard, Vancouver, ISO, and other styles
36

Lesesve, J. F., M. Martin, C. Banasiak, et al. "Schistocytes in disseminated intravascular coagulation." International Journal of Laboratory Hematology 36, no. 4 (2013): 439–43. http://dx.doi.org/10.1111/ijlh.12168.

Full text
APA, Harvard, Vancouver, ISO, and other styles
37

Ghafari, G., M. S. Dhesi, and M. Grant. "Multifaceted Interventions to Enable Elimination of Clinician-ordered Blood Smear Reviews: A Rural Academic Medical Center Experience." American Journal of Clinical Pathology 162, Supplement_1 (2024): S102. http://dx.doi.org/10.1093/ajcp/aqae129.227.

Full text
Abstract:
Abstract Introduction/Objective Blood smears (BS) evaluate a variety of clinical disorders. At Geisinger, clinician ordered pathologist review of blood smears (CBS) have increased despite usage of highly sophisticated hematology analyzers and automatic blood smear (ABS) review criteria. We hypothesized that CBS impact pathologists’ and technologists’ workloads and increase costs and turn-around times, with rare improvement in value-based patient care. This study aimed to analyze CBS ordering practices and improve the utilization of BS review. Methods/Case Report In October 2020, a prospective CBS utilization study was completed by 8 clinical pathologists for 172 CBS. Subsequently, a clinical question was required for CBS orders from January 1, 2022, to January 1, 2023, to investigate clinician ordering practices based on campus, department, and indications. Findings were used to support new interventions including: clinician education; cancellation of repeat BS ordered within 24 hours, creation of alternative tests (schistocyte technologist smear review, clinician order for independent slide review), standardization of morphology reporting, ABS audits, and elimination of orderable CBS replaced by an electronic BS review request, that is reviewed by a clinical pathologist prior to determine if a BS is indicated. Results (if a Case Study enter NA) Part of the Conclusions section for Lab Practice abstract. Conclusion Prospective utilization audit of 172 CBS orders showed 17% changed clinical management. Audit of 3,693 CBS orders demonstrated common reasons for review included tick-borne illness, hemolysis, erythrocytosis, thrombocytosis, and iron deficiency anemia. Systematic implementation of multiple interventions enabled the elimination of CBS, with no known adverse effect on patient management to date. The streamlined BS review guidelines allowed for better-allocation of resources, appropriate patient turn-around times, empowerment of laboratory technologists and reduced hospital costs. We propose maximizing the incorporation of technologist skills to improve the utilization and efficiency of BS reviews and establishing standardized, evidence-based, and institutional- specific guidelines to determine BS reviews.
APA, Harvard, Vancouver, ISO, and other styles
38

Tefferi, Ayalew, and Michelle A. Elliott. "Schistocytes on the Peripheral Blood Smear." Mayo Clinic Proceedings 79, no. 6 (2004): 809. http://dx.doi.org/10.4065/79.6.809.

Full text
APA, Harvard, Vancouver, ISO, and other styles
39

Tefferi, Ayalew, and Michelle A. Elliott. "Schistocytes on the Peripheral Blood Smear." Mayo Clinic Proceedings 79, no. 6 (2004): 809. http://dx.doi.org/10.1016/s0025-6196(11)62635-9.

Full text
APA, Harvard, Vancouver, ISO, and other styles
40

Aliyu, Bello. "Geology and Geochemistry of Aberma and Its Environ Sheet 54se Gusau, Zamfara State, Nigeria." Earth Sciences 13, no. 3 (2024): 86–96. http://dx.doi.org/10.11648/j.earth.20241303.11.

Full text
Abstract:
The study area falls within the northwestern part of Nigeria and is underlain by crystalline rocks of the Basement Complex. Field mapping in Aberma and its environs were carried out using topographical map sheet of 54 SE Gusau on a scale 1: 25,000 with an area extends of about 30.8052km2. This field work was carried out using traverse method in conjunction with field equipment such as compass/clinometers, geologic hammer, sample bag and global positioning system. This study however, aims at producing a detail geological map, including the various rock geochemistry and petrography of the study area. The area is underlain by two major lithological rock type which is mica schist and granite gneiss. The granite gneiss is strongly foliated, caused by high temperature and pressure and the minerals observed in plane polarized light include quartz, orthoclase, plagioclase, muscovite, opaque mineral and biotite. The mica schists in the study area are mostly weathered in ditches below the ground surface, the rock is moderately weathered and show schistocyte. The minerals observed in plane polarized light include quartz and muscovite. The dominant structures observed include; joints, Quartz veins, foliation and pegmatite dyke. Structural analysis shows that the rocks have been affected by the Pan African orogeny with the joint’s orientation trending dominantly NNE-SSW and Quartz vein trending in somewhat E-W direction. The microscopic studies revealed that the mineralogical composition of the rocks types of the study area contain varying percentages of quartz, muscovite, plagioclase, orthoclase, opaque mineral and biotite as the major minerals. The geochemical analysis revealed the major and minor elemental distribution of the rock types of the study area. The chemical assay revealed that the granite gneiss and mica schist rock type of the study area are super-saturated with respect to silica, silica (SiO<sub>2</sub>) is the most abundant oxide with an average value of 78.12% in the rock sample. This implies that the rock analyzed is acidic in nature and must have formed from crystallization of an acidic magma because the silica content being greater than 65%.
APA, Harvard, Vancouver, ISO, and other styles
41

Md., Imteyaz Alam, Bharti Madhu, Kumar Jha Manish, and Kumar Poonam. "A Hospital-Based Assessment of the Hematological Parameters in Patients with Covid-19 Infection: An Observational Study." International Journal of Current Pharmaceutical Review and Research 15, no. 11 (2023): 52–58. https://doi.org/10.5281/zenodo.11548667.

Full text
Abstract:
AbstractAim: The aim of the present study was to evaluate the abnormalities in hematological parameters among severeacute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected patients in a tertiary care hospital.Material & Methods: This was a cross-sectional study carried out in Department of Pathology, The studyperiod was of 12 months. Includes all patients confirmed with COVID-19 infection. A confirmed 100 case ofCOVID-19 was defined by a positive result on the reverse transcriptase polymerase chain reaction (RT-PCR)assay of a specimen collected on a nasopharyngeal swab. Informed consent was obtained from all patientsduring blood sample collection.Results: In the present study, a total of 100 patients confirmed with COVID-19 infection were included, out ofwhich 60 (60%) were males and 40 (40%) were females. The majority of the patients (77%) were more than 40years of age. In this study, all the patients including both males and females were categorized into three groupsbased on hemoglobin levels. Out of the 100 patients, 49 cases (49%) had adequate hemoglobin levels of above12g/dl, around 43 cases (43%) had a mild reduction in the hemoglobin value, and only 8 cases (8%) hadmoderate anemia with hemoglobin levels less than 10g/dl. In this study, 68 cases (68%) had a WBC count in thenormal range while 22 cases (22%) had leukopenia, and 10 cases (10%) had leucocytosis.Conclusion: The common hematological abnormalities in patients with COVID-19 infection were elevatedNLR, lymphopenia, thrombocytopenia, and elevated D-dimer levels. Some of the hematological parametersincluding elevated NLR, thrombocytopenia, and lymphopenia have been found to correlate with the clinicalseverity of the SARS-COV-2 infection in many patients and are useful in monitoring the patients during thecourse of the disease.
APA, Harvard, Vancouver, ISO, and other styles
42

Savjani, Maushmi, Padma Draksharam, and Albert S. Braverman. "Schistocytosis in B12 Deficiency (B12D) Reduces the MCV and Raises the RDW in the Absence of Iron Deficiency: a Cause of Unnecessary Plasmapheresis (PP)." Blood 128, no. 22 (2016): 4816. http://dx.doi.org/10.1182/blood.v128.22.4816.4816.

Full text
Abstract:
Abstract Background: RBC size variation and microcytes in B12D are often ascribed, but rarely shown, to be due to co-existing Fe deficiency. Schistocytes (aka poikilocytes) were included in early descriptions of pernicious anemia (PA). As it also causes thrombocytopenia, B12D may be confused with thrombotic thrombocytopenic purpura (TTP). Because of the urgency of PP for TTP, it has sometimes been initial therapy for B12D with schistocytes. Purpose: Here we describe 3 PA patients, and review reports of 15 other severely anemic B12D cases, with schistocytes. As they are smaller than mature RBC, they may normalize the MCV, while raising the RDW. We wished to determine whether primary lab studies help to distinguish B12D from TTP. Case Reports: These patients presented with symptoms of severe anemia: Ferritins were normal or high, haptoglobins <30, anti-intrinsic factor and parietal cell antibodies present, and complete response to B12 therapy occurred. Significant numbers of schistocytes were present in all, as was a distinctive population of minute, hypochromic schistocytes (MHS). Review: We found 15 reports of individual B12D patients with schistocytes, published between 2003 and 2015. All but 2 vegans had PA, 6 being anti-IF Ab+. Median & median ages were 52 & 53, [Hb]'s 5.9 & 6.0, MCV's 120 & 117 (3 normal), platelets 97 & 85, WBC 3200 & 3120, LDH's 4050 & 5860; reticulocyte levels were all low for severe anemia. Iron deficiency anemia was not found; ferritin and/or Fe/TIBC were reported normal in 4. Six legible blood smear microphotographs were included, confirming schistocytosis. Five patients had one or more PP before B12 deficiency was discovered. All 15 responded completely to B12. MHS were also observed on 4 of the 6 legible microphotographs, and noted by authors. For comparison, our survey of 36 reported TTP legible blood smears failed to detect MHC. Conclusions: Schistocytes are observed in some severely anemic B12D, may account for as much as 6.7% of RBC, and alter their indices. Schistocytosis and thrombocytopenia suggest TTP, and may lead to unnecessary PP. But such patients' low reticulocyte counts and very high LDH levels are not typical of TTP. Table Table. Figure 1 Figure 1. Figure 2 Figure 2. Disclosures No relevant conflicts of interest to declare.
APA, Harvard, Vancouver, ISO, and other styles
43

Lesesve, J.-F., S. Salignac, T. Lecompte, and P. Bordigoni. "Automated measurement of schistocytes after bone marrow transplantation." Bone Marrow Transplantation 34, no. 4 (2004): 357–62. http://dx.doi.org/10.1038/sj.bmt.1704601.

Full text
APA, Harvard, Vancouver, ISO, and other styles
44

Ruzman Azlee, Ruzanaz Syafira, Razan Hayati Zulkeflee, and Sumaiyah Adzahar. "A hematologist's urgent concern: Schistocytes with a headache." Visual Journal of Emergency Medicine 35 (April 2024): 101984. http://dx.doi.org/10.1016/j.visj.2024.101984.

Full text
APA, Harvard, Vancouver, ISO, and other styles
45

Yu, Kevin, and Min Yan. "A Case of Thrombotic Thrombocytopenic Purpura without Pathognomonic Schistocytes." Clinics and Practice 11, no. 2 (2021): 223–27. http://dx.doi.org/10.3390/clinpract11020033.

Full text
Abstract:
Patients diagnosed with thrombotic thrombocytopenic purpura (TTP) typically present with microangiopathic hemolytic anemia (MAHA) and thrombocytopenia; these two clinical manifestations were often believed to be essential indicators of TTP. However, such indicators are not always present in every case. Here, we present a patient affected by TTP but showing no distinctive schistocytes on blood smear review. TTP was diagnosed through a critically low level of a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13 (ADAMTS13) activity. Awareness of such an atypical presentation of TTP is essential for timely treatment to prevent serious and even fatal outcomes for patients.
APA, Harvard, Vancouver, ISO, and other styles
46

Koubaissi, Salwa A., and Jad A. Degheili. "Severe Cobalamin Deficiency Disguised as Schistocytes: A Case Report." American Journal of Case Reports 20 (November 17, 2019): 1691–94. http://dx.doi.org/10.12659/ajcr.918807.

Full text
APA, Harvard, Vancouver, ISO, and other styles
47

Fava, Stephen, and Alfred Caruana Galizia. "Thrombotic thrombocytopenic purpura-like syndrome in the absence of schistocytes." British Journal of Haematology 89, no. 3 (1995): 643–44. http://dx.doi.org/10.1111/j.1365-2141.1995.tb08379.x.

Full text
APA, Harvard, Vancouver, ISO, and other styles
48

Daram, Sumanth R., Marie Philipneri, Nidhi Puri, and Bahar Bastani. "Thrombotic Thrombocytopenic Purpura Without Schistocytes on the Peripheral Blood Smear." Southern Medical Journal 98, no. 3 (2005): 392–95. http://dx.doi.org/10.1097/01.smj.0000136231.83564.f6.

Full text
APA, Harvard, Vancouver, ISO, and other styles
49

ZINI, G., G. d’ONOFRIO, C. BRIGGS, et al. "ICSH recommendations for identification, diagnostic value, and quantitation of schistocytes." International Journal of Laboratory Hematology 34, no. 2 (2011): 107–16. http://dx.doi.org/10.1111/j.1751-553x.2011.01380.x.

Full text
APA, Harvard, Vancouver, ISO, and other styles
50

ABU-HASHISH, HUSSEIN, CRYSTAL WONG, GEORGINA ANG, and GABRIEL JUNG. "GOT SCHISTOCYTES? A CASE OF DELAYED AUTOIMMUNE THROMBOTIC THROMBOCYTOPENIC PURPURA." CHEST 164, no. 4 (2023): A2196—A2197. http://dx.doi.org/10.1016/j.chest.2023.07.1488.

Full text
APA, Harvard, Vancouver, ISO, and other styles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography