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Journal articles on the topic 'Schistosomose – Diagnostic'

Author: Grafiati

Published: 9 February 2024

Last updated: 31 July 2025

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1

Diaw, O. T., M. Seye, M. Mb. Seye, et al. "Diagnostic expérimental (ELISA) de la schistosomose ovine au Sénégal." Revue d’élevage et de médecine vétérinaire des pays tropicaux 51, no. 4 (1998): 321–25. http://dx.doi.org/10.19182/remvt.9616.

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Ce travail a eu pour objet de tester expérimentalement l'utilisation de la technique ELISA pour le diagnostic des schistosomoses à Schistosoma bovis et à S. curassoni chez le mouton au Sénégal. Un antigène brut à base de vers adultes de S. bovis a été utilisé dans cette analyse immunoenzymologique. L'ELISA a permis de détecter les premiers anticorps anti-Schistosoma dès la 6e semaine après l'infestation par S. bovis et dès la 9e semaine par S. curassoni, alors que les analyses coprologiques classiques ont été négatives jusqu'à la 8e semaine après l'infestation par S. bovis et la 10e semaine pa

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2

Oliosi, E., C. Leblanc, and S. Jaureguiberry. "Connaissances et attitudes concernant le diagnostic et le traitement de la schistosomose chronique d'importation parmi des infectiologues adultes et pédiatres en France." Médecine et Maladies Infectieuses Formation 4, no. 2 (2025): S112. https://doi.org/10.1016/j.mmifmc.2025.04.232.

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3

Leroy, J., B. Sendid, A. Deleplancque, et al. "Comparaison de deux stratégies de prise en charge de la schistosomose chez les migrants d'Afrique subsaharienne primo-arrivants dans une PASS : dépistage systématique versus diagnostic ciblé." Médecine et Maladies Infectieuses Formation 3, no. 2 (2024): S106. http://dx.doi.org/10.1016/j.mmifmc.2024.04.314.

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4

HOLA-JAMRISKA, L., J. P. DALTON, J. AASKOV, and P. J. BRINDLEY. "Dipeptidyl peptidase I and III activities of adult schistosomes." Parasitology 118, no. 3 (1999): 275–82. http://dx.doi.org/10.1017/s0031182098003746.

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Soluble extracts of adult Schistosoma japonicum and S. mansoni were examined for the presence of proteolytic activities ascribable to dipeptidyl peptidases (DPPs) at a range of pH from 4 to 11 using synthetic peptidyl substrates diagnostic of DPPs I, II, III and IV. Activity capable of cleaving the DPP I-specific substrates H-Gly-Arg-NHMec and H-Gly-Phe-NHMec which exhibited a pH optimum of 5·5 was observed in extracts of schistosomes. Female schistosomes exhibited greater DPP I activity than male schistosomes, while female S. japonicum showed substantially more activity than female S. mansoni

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Lakshmanan, B., K. Devada, S. Joseph, T. V. Aravindakshan, and L. Sabu. "Copro-PCR based detection of bovine schistosome infection in India." Journal of Helminthology 90, no. 1 (2015): 102–7. http://dx.doi.org/10.1017/s0022149x1400090x.

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AbstractSchistosomosis and amphistomosis are the two economically important and widely prevalent snail-borne trematode infections in grazing cattle of southern India. Acute infections are symptomatically similar and difficult to detect by routine microscopy for eggs. The present study was directed towards the development of a copro-polymerase chain reaction (copro-PCR) for detection of bovine schistosome species, using custom-designed primers targeting 18S and 28S ribosomal RNA as well as mitochondrial DNA. The study demonstrated the enhanced diagnostic specificity of mitochondrial DNA markers

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Ruppel, Andreas, Ute Breternitz, and Reinhard Burger. "Diagnostic Mr 31 000 Schistosoma mansoni proteins: requirement of infection, but not immunization, and use of the “miniblot” technique for the production of monoclonal antibodies." Journal of Helminthology 61, no. 2 (1987): 95–101. http://dx.doi.org/10.1017/s0022149x00009810.

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ABSTRACTAntibodies directed against diagnostic Mr 31 000 polypeptide(s) of adult Schistosoma mansoni were already formed in mice during prepatency. In contrast, repeated immunization of mice with homogenates of adult schistosomes failed to elicit antibodies detectable in immunoblots in the Mr 31 000 region. Therefore, spleen cells of infected mice were used to produce hybridoma lines. The “miniblot technique” was developed in order to detect in hybridoma supernatants antibodies against schistosome Mr 31 000 components. Electrophoretically separated total S. mansoni proteins were transferred on

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7

Kincaid-Smith, Julien, Alan Tracey, Ronaldo de Carvalho Augusto, et al. "Morphological and genomic characterisation of the Schistosoma hybrid infecting humans in Europe reveals admixture between Schistosoma haematobium and Schistosoma bovis." PLOS Neglected Tropical Diseases 15, no. 12 (2021): e0010062. http://dx.doi.org/10.1371/journal.pntd.0010062.

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Schistosomes cause schistosomiasis, the world’s second most important parasitic disease after malaria in terms of public health and social-economic impacts. A peculiar feature of these dioecious parasites is their ability to produce viable and fertile hybrid offspring. Originally only present in the tropics, schistosomiasis is now also endemic in southern Europe. Based on the analysis of two genetic markers the European schistosomes had previously been identified as hybrids between the livestock- and the human-infective species Schistosoma bovis and Schistosoma haematobium, respectively. Here,

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Weerakoon, Kosala, Catherine Gordon, and Donald McManus. "DNA Diagnostics for Schistosomiasis Control." Tropical Medicine and Infectious Disease 3, no. 3 (2018): 81. http://dx.doi.org/10.3390/tropicalmed3030081.

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Despite extensive efforts over the last few decades, the global disease burden of schistosomiasis still remains unacceptably high. This could partly be attributed to the lack of accurate diagnostic tools for detecting human and animal schistosome infections in endemic areas. In low transmission and low prevalence areas where schistosomiasis elimination is targeted, case detection requires a test that is highly sensitive. Diagnostic tests with low sensitivity will miss individuals with low infection intensity and these will continue to contribute to transmission, thereby interfering with the ef

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9

Nwoko, Onyekachi Esther, John J. O. Mogaka, and Moses John Chimbari. "Challenges and Opportunities Presented by Current Techniques for Detecting Schistosome Infections in Intermediate Host Snails: A Scoping Review." International Journal of Environmental Research and Public Health 18, no. 10 (2021): 5403. http://dx.doi.org/10.3390/ijerph18105403.

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Schistosomiasis, a neglected tropical disease (NTD), causes morbidity and mortality in over 250 million people globally. And 700 million people are at risk of contracting it. It is caused by a parasite of the genus Schistosoma. Freshwater snails of the family Planorbidae are of public health significance as they are intermediate hosts of these highly infective flukes. Accurate diagnostic techniques to detect schistosome infections in intermediate host snails (IHS) and environmental surveillance are needed to institute measures for the interruption of transmission and eventual elimination. We c

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FLORES, VERÓNICA, GUSTAVO VIOZZI, LAURA CASALINS, ERIC SAMUEL LOKER, and SARA VANESSA BRANT. "A new schistosome (Digenea: Schistosomatidae) from the nasal tissue of South America black-necked swans, Cygnus melancoryphus (Anatidae) and the endemic pulmonate snail Chilina gibbosa." Zootaxa 4948, no. 3 (2021): 404–18. http://dx.doi.org/10.11646/zootaxa.4948.3.5.

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To date, 9 species of Schistosomatidae have been found parasitizing the nasal tissues of mammal and bird hosts in the Eastern Hemisphere, 5 species in Rwanda (Africa), 2 in Australia (Oceania) and 2 in Eurasia. During a parasitological survey of black necked swans, Cygnus melancoryphus, an anatid endemic to South America, schistosome worms in the nasal tissue were found; the first in the Americas. Morphological results based on male worms and in isolated eggs. The worms have a spiny tegument, filiform body with rounded posterior end, two muscular suckers, a robust gynaecophoric channel with th

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YOU, HONG, and DONALD P. MCMANUS. "Vaccines and diagnostics for zoonotic schistosomiasis japonica." Parasitology 142, no. 2 (2014): 271–89. http://dx.doi.org/10.1017/s0031182014001310.

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SUMMARYSchistosomiasis is one of the most prevalent, insidious and serious of the tropical parasitic diseases. Although the effective anthelmintic drug, praziquantel, is widely available and cheap, it does not protect against re-infection, drug-resistant schistosome may evolve and mass drug administration programmes based around praziquantel are probably unsustainable long term. Whereas protective anti-schistosome vaccines are not yet available, the zoonotic nature of Schistosoma japonicum provides a novel approach for developing a transmission-blocking veterinary vaccine in domestic animals,

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Hamouda, Ouanassa, Noureddine Boukhrouf, and Souad Bensassi. "Urinary Schistosoma haematobium schistosomiasis. A case report." Batna Journal of Medical Sciences (BJMS) 5, no. 1 (2018): 84–86. http://dx.doi.org/10.48087/bjmscr.2018.5120.

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La schistosomiase urinaire est une infection intravasculaire causée par un trématode (ver plat) Schistosoma haematobium. Les vers adultes migrent généralement vers le plexus veineux de la vessie humaine et excrètent les oeufs que la personne infectée élimine dans l'urine. Nous rapportons le cas d’un patient âgé de 20 ans, avec des antécédents familiaux de bilharziose. Originaire du Mali et résidant à Batna (Algérie), il a présenté une douleur pelvienne, des brûlures mictionnelles et une hématurie terminale, avec une hyperéosinophilie de 920 / μL. L´échographie abdomino-pelvienne a mis en évide

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Wilson, R. Alan. "Schistosomiasis then and now: what has changed in the last 100 years?" Parasitology 147, no. 5 (2020): 507–15. http://dx.doi.org/10.1017/s0031182020000049.

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AbstractOnly with the completion of the life cycles of Fasciola hepatica in 1883 and 30 years later those of Schistosoma japonicum (1913), Schistosoma haematobium and Schistosoma mansoni (1915) did research on schistosomiasis really get underway. One of the first papers by Cawston in 1918, describing attempts to establish the means of transmission of S. haematobium in Natal, South Africa, forms the historical perspective against which to judge where we are now. Molecular biology techniques have produced a much better definition of the complexity of the schistosome species and their snail hosts

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Bergquist, Robert, and Hala Elmorshedy. "Artemether and Praziquantel: Origin, Mode of Action, Impact, and Suggested Application for Effective Control of Human Schistosomiasis." Tropical Medicine and Infectious Disease 3, no. 4 (2018): 125. http://dx.doi.org/10.3390/tropicalmed3040125.

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The stumbling block for the continued, single-drug use of praziquantel (PZQ) against schistosomiasis is less justified by the risk of drug resistance than by the fact that this drug is inactive against juvenal parasites, which will mature and start egg production after chemotherapy. Artemisinin derivatives, currently used against malaria in the form of artemisinin-based combination therapy (ACT), provide an opportunity as these drugs are not only active against malaria plasmodia, but surprisingly also against juvenile schistosomes. An artemisinin/PZQ combination would be complimentary, and pot

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Gabriel Bishop, Henry, Helen Ileigo Inabo, Elijah Ekah Ella, and Mohammed Bello. "Two cases of urinary schistosomiasis with unusual egg presentations: Dra 1 repeat sequence not detected." Case Reports International 12, no. 2 (2023): 10–14. http://dx.doi.org/10.5348/100120z06hb2023cr.

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Introduction: Schistosoma haematobium is the primary cause of urinary schistosomiasis in man. It is rare to find other human schistosome species in urine because they are located in the intestines, or those of animal origin. Mixed infections of human and animal species of schistosomes may occur in cattle breeding areas like Nigeria. Case Report: During a prevalence study on urinary schistosomiasis, two teenage boys from different local government areas (LGAs) of Kaduna State, Nigeria had mixed urinary Schistosoma infections. Their urine samples were centrifuged at 3000 rpm (revolutions per min

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16

Pennance, Tom, John Archer, Elena Birgitta Lugli, et al. "Development of a Molecular Snail Xenomonitoring Assay to Detect Schistosoma haematobium and Schistosoma bovis Infections in their Bulinus Snail Hosts." Molecules 25, no. 17 (2020): 4011. http://dx.doi.org/10.3390/molecules25174011.

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Schistosomiasis, a neglected tropical disease of medical and veterinary importance, transmitted through specific freshwater snail intermediate hosts, is targeted for elimination in several endemic regions in sub-Saharan Africa. Multi-disciplinary methods are required for both human and environmental diagnostics to certify schistosomiasis elimination when eventually reached. Molecular xenomonitoring protocols, a DNA-based detection method for screening disease vectors, have been developed and trialed for parasites transmitted by hematophagous insects, such as filarial worms and trypanosomes, ye

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17

Mekonnen, Gebeyaw G., Bemnet A. Tedla, Mark S. Pearson, et al. "Characterisation of tetraspanins from Schistosoma haematobium and evaluation of their potential as novel diagnostic markers." PLOS Neglected Tropical Diseases 16, no. 1 (2022): e0010151. http://dx.doi.org/10.1371/journal.pntd.0010151.

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Schistosoma haematobium is the leading cause of urogenital schistosomiasis and it is recognised as a class 1 carcinogen due to the robust association of infection with bladder cancer. In schistosomes, tetraspanins (TSPs) are abundantly present in different parasite proteomes and could be potential diagnostic candidates due to their accessibility to the host immune system. The large extracellular loops of six TSPs from the secretome (including the soluble excretory/secretory products, tegument and extracellular vesicles) of S. haematobium (Sh-TSP-2, Sh-TSP-4, Sh-TSP-5, Sh-TSP-6, Sh-TSP-18 and S

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Kamel, Bishoy, Martina R. Laidemitt, Lijun Lu, et al. "Detecting and identifying Schistosoma infections in snails and aquatic habitats: A systematic review." PLOS Neglected Tropical Diseases 15, no. 3 (2021): e0009175. http://dx.doi.org/10.1371/journal.pntd.0009175.

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Background We were tasked by the World Health Organization (WHO) to address the following question: What techniques should be used to diagnose Schistosoma infections in snails and in the water in potential transmission sites? Our goal was to review and evaluate the available literature and provide recommendations and insights for the development of WHO’s Guidelines Development Group for schistosomiasis control and elimination. Methodology We searched several databases using strings of search terms, searched bibliographies of pertinent papers, and contacted investigators who have made contribut

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Ogongo, Paul, Thomas M. Kariuki, and R. Alan Wilson. "Diagnosis of schistosomiasis mansoni: an evaluation of existing methods and research towards single worm pair detection." Parasitology 145, no. 11 (2018): 1355–66. http://dx.doi.org/10.1017/s0031182018000240.

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AbstractThe inadequacy of current diagnostics for the detection of low worm burdens in humans means that schistosomiasis mansoni is more widespread than previously acknowledged. With the inception of mass drug treatment programmes aimed at disease elimination and the advent of human vaccine trials, the need for more sensitive diagnostics is evident. In this review, we evaluate the merits and limitations of the principal diagnostic methods, namely detection of eggs in faeces; anti-schistosome antibodies in serum; parasite-derived proteins and glycans in serum or urine; parasite DNA in blood, fa

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Vengesai, Arthur, Marble Manuwa, Herald Midzi, et al. "Identification of Schistosoma haematobium and Schistosoma mansoni linear B-cell epitopes with diagnostic potential using in silico immunoinformatic tools and peptide microarray technology." PLOS Neglected Tropical Diseases 18, no. 8 (2024): e0011887. http://dx.doi.org/10.1371/journal.pntd.0011887.

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Introduction Immunoinformatic tools can be used to predict schistosome-specific B-cell epitopes with little sequence identity to human proteins and antigens other than the target. This study reports an approach for identifying schistosome peptides mimicking linear B-cell epitopes using in-silico tools and peptide microarray immunoassay validation. Method Firstly, a comprehensive literature search was conducted to obtain published schistosome-specific peptides and recombinant proteins with the best overall diagnostic performances. For novel peptides, linear B-cell epitopes were predicted from t

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Chen, Yuning. "Neuroschistosomiasis and the Central Nervous System." Highlights in Science, Engineering and Technology 19 (November 17, 2022): 175–81. http://dx.doi.org/10.54097/hset.v19i.2848.

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Schistosomes are the main cause of the neglected tropical disease schistosomiasis. As one of the most serious clinical consequences, neuroschistosomiasis occurs when the host exhibits an inflammatory reaction to eggs of schistosomes laid in the brain and the spinal cord. Two major kinds of neuroschistosomiasis are cerebral schistosomiasis and spinal schistosomiasis, which are associated with different types of schistosomes. Cerebral schistosomiasis can be acute, which leads to symptoms such as fever, delirium, visual impairment, ataxia, and headache, whereas chronic cerebral schistosomiasis us

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Oliveira, Guilherme, Nilton B. Rodrigues, Alvaro J. Romanha, and Diana Bahia. "Genome and genomics of schistosomes." Canadian Journal of Zoology 82, no. 2 (2004): 375–90. http://dx.doi.org/10.1139/z03-220.

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Schistosomes infect over 200 million people and 600 million are at risk. Genomics and post-genomic studies of schistosomes will contribute greatly to developing new reagents for diagnostic purposes and new vaccines that are of interest to the biotechnology industry. In this review, the most recent advances in these fields as well as new projects and future perspectives will de described. A vast quantity of data is publicly available, including short cDNA and genomic sequences, complete large genomic fragments, and the mitochondrial genomes of three species of the genus Schistosoma. The physica

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Schwartz, Eli, Neora Pick, Gila Shazberg, and Israel Potasman. "Hematospermia Due to Schistosome Infection in Travelers: Diagnostic and Treatment Challenges." Clinical Infectious Diseases 35, no. 11 (2002): 1420–24. http://dx.doi.org/10.1086/344063.

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Webster, B. L., D. Rollinson, J. R. Stothard, and T. Huyse. "Rapid diagnostic multiplex PCR (RD-PCR) to discriminate Schistosoma haematobium and S. bovis." Journal of Helminthology 84, no. 1 (2009): 107–14. http://dx.doi.org/10.1017/s0022149x09990447.

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AbstractSchistosoma haematobium and S. bovis are widespread schistosome species causing human and cattle schistosomiasis, respectively, in Africa. The sympatric occurrence of these two species and their ability to infect the same Bulinus intermediate snail hosts necessitates precise methods of identification of the larval stages. A rapid diagnostic ‘mulitplex’ one-step polymerase chain reaction protocol (RD-PCR) was developed using cytochrome oxidase subunit 1 (COX1) mitochondrial DNA (mtDNA) to discriminate between S. haematobium and S. bovis. A single forward primer and two species-specific

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Liang, Song, Keerati Ponpetch, Yi-Biao Zhou, et al. "Diagnosis of Schistosoma infection in non-human animal hosts: A systematic review and meta-analysis." PLOS Neglected Tropical Diseases 16, no. 5 (2022): e0010389. http://dx.doi.org/10.1371/journal.pntd.0010389.

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Background Reliable and field-applicable diagnosis of schistosome infections in non-human animals is important for surveillance, control, and verification of interruption of human schistosomiasis transmission. This study aimed to summarize uses of available diagnostic techniques through a systematic review and meta-analysis. Methodology and principal findings We systematically searched the literature and reports comparing two or more diagnostic tests in non-human animals for schistosome infection. Out of 4,909 articles and reports screened, 19 met our inclusion criteria, four of which were con

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Ally, Ombeni, Bernard N. Kanoi, Lucy Ochola, et al. "Schistosomiasis diagnosis: Challenges and opportunities for elimination." PLOS Neglected Tropical Diseases 18, no. 7 (2024): e0012282. http://dx.doi.org/10.1371/journal.pntd.0012282.

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Overview The roadmap adopted by the World Health Organization (WHO) for eliminating neglected tropical diseases aims to eliminate schistosomiasis, as a public health concern, by 2030. While progress has been made towards reducing schistosomiasis morbidity control in several sub-Saharan African countries, there is still more that needs to be done. Proper surveillance using accurate diagnostics with acceptable sensitivity and specificity is essential for evaluating the success of all efforts against schistosomiasis. Microscopy, despite its low sensitivity, remains the gold standard approach for

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Newport, George R., Nina Agabian, Jeff Kallestad, Phillip Tarr, Richard C. Hedstrom, and Seymour Klebanoff. "Identification, Molecular Cloning, and Expression of a Schistosome Antigen Displaying Diagnostic Potential." American Journal of Tropical Medicine and Hygiene 38, no. 3 (1988): 540–46. http://dx.doi.org/10.4269/ajtmh.1988.38.540.

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HAMILTON, J. V., P. L. CHIODINI, P. G. FALLON, and M. J. DOENHOFF. "Periodate-sensitive immunological cross-reactivity between keyhole limpet haemocyanin (KLH) and serodiagnostic Schistosoma mansoni egg antigens." Parasitology 118, no. 1 (1999): 83–89. http://dx.doi.org/10.1017/s0031182098003461.

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Both CEF6, a cation-exchange fraction of soluble Schistosoma mansoni egg antigens (SEA), composed of the 2 antigens, alpha-1 and omega-1, and haemocyanin from the keyhole limpet, Megathura crenulata, have shown potential for immunodiagnosis of human schistosomiasis. Possible cross-reactivity between antigens in SEA and keyhole limpet haemocyanin (KLH) was explored by Western immunoblotting and enzyme-linked immunosorbent assay (ELISA) using sera from rabbits immunized with KLH, SEA, CEF6, alpha-1, omega-1, or egg antigen k5. Both immunoassays revealed a high degree of serological cross-reactiv

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Hoekstra, Pytsje T., Joule Madinga, Pascal Lutumba, et al. "Diagnosis of Schistosomiasis without a Microscope: Evaluating Circulating Antigen (CCA, CAA) and DNA Detection Methods on Banked Samples of a Community-Based Survey from DR Congo." Tropical Medicine and Infectious Disease 7, no. 10 (2022): 315. http://dx.doi.org/10.3390/tropicalmed7100315.

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Detection of Schistosoma eggs in stool or urine is known for its low sensitivity in diagnosing light infections. Alternative diagnostics with better sensitivity while remaining highly specific, such as real-time PCR and circulating antigen detection, are progressively used as complementary diagnostic procedures but have not yet replaced microscopy. This study evaluates these alternative methods for the detection of Schistosoma infections in the absence of microscopy. Schistosomiasis presence was determined retrospectively in 314 banked stool and urine samples, available from a previous survey

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Zanisi, Laura, Pietro Benedetto Faré, and Gabriele Poncini. "Diagnostic de schistosomiase urinaire par l’identification de miracidiums de [i]Schistosoma haematobium[/i]." Revue Médicale Suisse 14, no. 605 (2018): 944–48. http://dx.doi.org/10.53738/revmed.2018.14.605.0944.

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Meghani, Nileshkumar, Beom-Jin Lee, Hardik Amin, Behzad Nili-Ahmadabadi, and Saraswathy Nagendran. "Current Progress on the Genomics of Schistosomiasis for Drug Discovery and Diagnostics." Infectious Disorders - Drug Targets 20, no. 5 (2020): 598–610. http://dx.doi.org/10.2174/1871526519666191015170536.

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For a number of decades, schistosomiasis has remained a public threat and an economic burden in a number of countries, directly impacting over 200 million people. The past 15 years have seen tremendous progress in the development of high-throughput methods for targeting or compound selection that are vital to early-stage schistosome drug discovery research. Genomewide approaches to analyze gene expression at the transcriptional and other -omic levels have helped immensely for gaining insight into the pathways and mechanisms involved in the schistosomiasis and it is expected to revolutionize th

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Schols, Ruben, Hans Carolus, Cyril Hammoud, Stephen Mulero, Aspire Mudavanhu, and Tine Huyse. "A rapid diagnostic multiplex PCR approach for xenomonitoring of human and animal schistosomiasis in a ‘One Health’ context." Transactions of The Royal Society of Tropical Medicine and Hygiene 113, no. 11 (2019): 722–29. http://dx.doi.org/10.1093/trstmh/trz067.

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Abstract Studying the epidemiology of schistosomiasis—the most prevalent gastropod-borne human disease and an economic burden for the livestock industry—relies on adequate monitoring tools. Here we describe a molecular assay for detecting human and animal African schistosome species in their planorbid gastropod host (xenomonitoring) using a two-step approach. First, schistosome infections are detected and discriminated from other trematode infections using a multiplex polymerase chain reaction (PCR) that includes a trematode-specific marker (in 18S rDNA), a Schistosoma genus-specific marker (i

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Lamberton, Poppy. "Schistosomiasis solution is not as simple as mass drug administration: Lamberton Lab takes a holistic approach to break the cycle of infection." Project Repository Journal 14, no. 1 (2022): 60–64. http://dx.doi.org/10.54050/prj1419274.

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Schistosomiasis solution is not as simple as mass drug administration: Lamberton Lab takes a holistic approach to break the cycle of infection Schisto_Persist aims to understand why schistosomiasis is not reducing in some areas despite nearly 20 years of mass drug administration. Overarching questions: What is the best way to monitor schistosome infections and drug efficacy? Has praziquantel resistance been selected for and what is its potential for spread? What other factors drive maintained transmission? What other factors affect parasite clearance? All require improved diagnostics and inter

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Karl, Stephan, Lucía Gutiérrez, Rafael Lucyk-Maurer, et al. "The Iron Distribution and Magnetic Properties of Schistosome Eggshells: Implications for Improved Diagnostics." PLoS Neglected Tropical Diseases 7, no. 5 (2013): e2219. http://dx.doi.org/10.1371/journal.pntd.0002219.

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WILSON, R. ALAN. "Proteomics at the schistosome-mammalian host interface: any prospects for diagnostics or vaccines?" Parasitology 139, no. 9 (2012): 1178–94. http://dx.doi.org/10.1017/s0031182012000339.

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SUMMARYSince 2004 there has been a remarkable increment in our knowledge of the proteins and glycans that reside at, or are released from the surfaces of schistosomes in the mammalian host. Initial characterization of the soluble proteome permits distinctions to be made between the parasite secretome and its necrotome. The principal proteins secreted by the cercaria to gain access to the skin have been described as well as those released by migrating schistosomula. An inventory of transporters, enzymes and structural proteins has been shown to reside the tegument surface, but also immunoglobul

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Nascimento-Carvalho, Cristiana M., and Otávio A. Moreno-Carvalho. "Neuroschistosomiasis due to Schistosoma mansoni: a review of pathogenesis, clinical syndromes and diagnostic approaches." Revista do Instituto de Medicina Tropical de São Paulo 47, no. 4 (2005): 179–84. http://dx.doi.org/10.1590/s0036-46652005000400001.

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Neuroschistosomiasis (NS) is the second most common form of presentation of infection by the trematode, Schistosoma mansoni. Granulomatous inflammatory reaction occurs as a result of schistosome eggs being transmitted to spinal cord or brain via the vascular system, or by inadvertent adult worm migration to these organs. The two main clinical syndromes are spinal cord neuroschistosomiasis (acute or subacute myelopathy) and localized cerebral or cerebellar neuroschistosomiasis (focal CNS impairment, seizures, increased intracranial pressure). Presumptive diagnosis of NS requires confirming the

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Cheever, A. W. "Decalcification of Schistosome Eggs during Staining of Tissue Sections: A Potential Source of Diagnostic Error." American Journal of Tropical Medicine and Hygiene 35, no. 5 (1986): 959–61. http://dx.doi.org/10.4269/ajtmh.1986.35.959.

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Kayuni, S. A., P. L. A. M. Corstjens, E. J. LaCourse, et al. "How can schistosome circulating antigen assays be best applied for diagnosing male genital schistosomiasis (MGS): an appraisal using exemplar MGS cases from a longitudinal cohort study among fishermen on the south shoreline of Lake Malawi." Parasitology 146, no. 14 (2019): 1785–95. http://dx.doi.org/10.1017/s0031182019000969.

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AbstractWe provide an update on diagnostic methods for the detection of urogenital schistosomiasis (UGS) in men and highlight that satisfactory urine-antigen diagnostics for UGS lag much behind that for intestinal schistosomiasis, where application of a urine-based point-of-care strip assay, the circulating cathodic antigen (CCA) test, is now advocated. Making specific reference to male genital schistosomiasis (MGS), we place greater emphasis on parasitological detection methods and clinical assessment of internal genitalia with ultrasonography. Unlike the advances made in defining a clinical

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Casacuberta-Partal, Miriam, Lisette van Lieshout, Angela van Diepen, et al. "Excretion patterns of Schistosoma mansoni antigens CCA and CAA by adult male and female worms, using a mouse model and ex vivo parasite cultures." Parasitology 149, no. 3 (2021): 306–13. http://dx.doi.org/10.1017/s0031182021001839.

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AbstractAssays which enable the detection of schistosome gut-associated circulating anodic (CAA) and cathodic (CCA) antigen in serum or urine are increasingly used as a diagnostic tool for schistosome infection. However, little is known about the production and clearance of these circulating antigens in relation to the sex and reproductive maturity of the parasite. Here we describe CAA and CCA excretion patterns by exploring a mouse model after exposure to 36 male-only, female-only and mixed (male/female) Schistosoma mansoni cercariae. We found that serum and urine CAA levels, analysed at 3 we

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Mickum, Megan L., Nina Salinger Prasanphanich, Xuezheng Song, et al. "Identification of Antigenic Glycans from Schistosoma mansoni by Using a Shotgun Egg Glycan Microarray." Infection and Immunity 84, no. 5 (2016): 1371–86. http://dx.doi.org/10.1128/iai.01349-15.

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Infection of mammals by the parasitic helminthSchistosoma mansoniinduces antibodies to glycan antigens in worms and eggs, but the differential nature of the immune response among infected mammals is poorly understood. To better define these responses, we used a shotgun glycomics approach in which N-glycans from schistosome egg glycoproteins were prepared, derivatized, separated, and used to generate an egg shotgun glycan microarray. This array was interrogated with sera from infected mice, rhesus monkeys, and humans and with glycan-binding proteins and antibodies to gather information about th

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Lista, Simone, and Enzo Emanuele. "Analysis of mitochondrial DNA by PCR/DHPLC as a diagnostic tool to differentiate schistosomes species and strains." Medical Hypotheses 68, no. 3 (2007): 707–8. http://dx.doi.org/10.1016/j.mehy.2006.09.018.

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Elamin Bushara, Sarra Osman, Sara Elfadil Abbas Mohammed, Elnour Mohamed Elagib, and Hatim Mohamed Yousif Mudawi. "Acute Schistosomal Colitis Preceded by Katayama Syndrome." Journal of Digestive Endoscopy 08, no. 02 (2017): 083–85. http://dx.doi.org/10.4103/jde.jde_52_16.

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ABSTRACTSchistosomiasis is prevalent in tropical and subtropical areas. It manifests as an acute or chronic illness caused by the body’s reaction to the worms’ eggs. In view of its clinical similarity to various other diseases, the disorder may cause diagnostic errors. We present a case of a Sudanese man, who presented with fever, headache, fatigue, myalgia, excessive sweating, abdominal cramps, and a high eosinophil count on blood testing. He was diagnosed with a connective tissue disorder and was started on prednisolone, but 3 weeks later, he presented with rectal bleeding. Colonoscopy showe

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Linder, Ewert, Sami Varjo, and Cecilia Thors. "Mobile Diagnostics Based on Motion? A Close Look at Motility Patterns in the Schistosome Life Cycle." Diagnostics 6, no. 2 (2016): 24. http://dx.doi.org/10.3390/diagnostics6020024.

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Onyekwere, Amos Mathias, Olivier Rey, Jean-François Allienne, et al. "Population Genetic Structure and Hybridization of Schistosoma haematobium in Nigeria." Pathogens 11, no. 4 (2022): 425. http://dx.doi.org/10.3390/pathogens11040425.

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Background: Schistosomiasis is a major poverty-related disease caused by dioecious parasitic flatworms of the genus Schistosoma with a health impact on both humans and animals. Hybrids of human urogenital schistosome and bovine intestinal schistosome have been reported in humans in several of Nigeria’s neighboring West African countries. No empirical studies have been carried out on the genomic diversity of Schistosoma haematobium in Nigeria. Here, we present novel data on the presence and prevalence of hybrids and the population genetic structure of S. haematobium. Methods: 165 Schistosoma-po

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Vengesai, Arthur, Victor Muleya, Herald Midzi, et al. "Diagnostic performances of Schistosoma haematobium and Schistosoma mansoni recombinant proteins, peptides and chimeric proteins antibody based tests. Systematic scoping review." PLOS ONE 18, no. 3 (2023): e0282233. http://dx.doi.org/10.1371/journal.pone.0282233.

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Background Traditional diagnostic tests for schistosome infections are suboptimal, particularly when the parasite burden is low. In the present review we sought to identify recombinant proteins, peptides, and chimeric proteins with potential to be used as sensitive and specific diagnostic tools for schistosomiasis. Methods The review was guided by PRISMA-ScR guidelines, Arksey and O’Malley’s framework, and guidelines from the Joanna Briggs Institute. Five databases were searched: Cochrane library, PubMed, EMBASE, PsycInfo and CINAHL, alongside preprints. Identified literature were assessed by

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Lv, Chao, Wangping Deng, Liping Wang, Zhiqiang Qin, Xiaonong Zhou, and Jing Xu. "Molecular Techniques as Alternatives of Diagnostic Tools in China as Schistosomiasis Moving towards Elimination." Pathogens 11, no. 3 (2022): 287. http://dx.doi.org/10.3390/pathogens11030287.

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Schistosomiasis japonica caused by the trematode flukes of Schistosoma japonicum was one of the most grievous infectious diseases in China in the mid-20th century, while its elimination has been placed on the agenda of the national strategic plan of healthy China 2030 after 70 years of continuous control campaigns. Diagnostic tools play a pivotal role in warfare against schistosomiasis but must adapt to the endemic status and objectives of activities. With the decrease of prevalence and infection intensity of schistosomiasis in human beings and livestock, optimal methodologies with high sensit

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Aradaib, Imadeldin Elamin, Elabbas Mohamed Ahdelmageed, Sanaa Ali Hassan, and Hans Peter Riemann. "A review on the diagnosis infection in cattle of Schistosoma bovis: current status and future prospects." Ciência Rural 25, no. 3 (1995): 493–98. http://dx.doi.org/10.1590/s0103-84781995000300029.

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Bovine schistosomiasis, caused by Schistosoma bovis, is a serious veterinary problem in many parts of the worid. The current methods used for the diagnosis of the disease include clinical signs, pathological lesions, parasitological and serological techniques. As clinical signs and parasitological lesions caused by S. bovis are indistinguishable from those induced by other trematode parasites, confirmation of diagnosis by these methods is unreliable. Parasitological techniques used to demonstrate eggs of the parasite in fecal or tissue samples represent the most accurate method for detection o

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Zhong, Haoran, Bowen Dong, Danlin Zhu та ін. "Schistosoma japonicum sja-let-7 Inhibits the Growth of Hepatocellular Carcinoma Cells via Cross-Species Regulation of Col1α2". Genes 15, № 9 (2024): 1165. http://dx.doi.org/10.3390/genes15091165.

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Liver fibrosis, a critical precursor to hepatocellular carcinoma (HCC), results from chronic liver injury and significantly contributes to HCC progression. Schistosomiasis, a neglected tropical disease, is known to cause liver fibrosis; however, this process can be modulated by schistosome-derived miRNAs. Previous studies from our laboratory have demonstrated that Schistosoma japonicum extracellular vesicles (EVs) deliver sja-let-7 to hepatic stellate cells, leading to the inhibition of Col1α2 expression and alleviation of liver fibrosis. Given the well-documented antifibrotic and antiprolifer

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Anyan, William K., Brittany R. Pulkkila, Clare E. Dyra, et al. "Assessment of dual schistosome infection prevalence from urine in an endemic community of Ghana by molecular diagnostic approach." Parasite Epidemiology and Control 9 (May 2020): e00130. http://dx.doi.org/10.1016/j.parepi.2019.e00130.

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Sengupta, Mita E., Micaela Hellström, Henry C. Kariuki, et al. "Environmental DNA for improved detection and environmental surveillance of schistosomiasis." Proceedings of the National Academy of Sciences 116, no. 18 (2019): 8931–40. http://dx.doi.org/10.1073/pnas.1815046116.

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Schistosomiasis is a water-based, infectious disease with high morbidity and significant economic burdens affecting >250 million people globally. Disease control has, with notable success, for decades focused on drug treatment of infected human populations, but a recent paradigm shift now entails moving from control to elimination. To achieve this ambitious goal, more sensitive diagnostic tools are needed to monitor progress toward transmission interruption in the environment, especially in low-intensity infection areas. We report on the development of an environmental DNA (eDNA)-based tool

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