Relevant bibliographies by topics / Schizonte

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  2. Dissertations / Theses
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  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Schizonte'

Author: Grafiati
Published: 4 June 2021
Last updated: 8 February 2022

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Journal articles on the topic "Schizonte"

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Pipano, E., and V. Shkap. "Observations sur la multiplication in vitro de cellules lymphoïdes bovines infectées par des schizontes de Theileria annulata." Revue d’élevage et de médecine vétérinaire des pays tropicaux 43, no. 4 (April 1, 1990): 485–88. http://dx.doi.org/10.19182/remvt.8767.

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La multiplication des cellules bovines de lignée lymphoïde infectées par les schizontes de Theileria annulata a été étudiée. Dans les cellules à division par mitose, le schizonte occupait une position centrale pendant les dernières phases de la division, partagée en deux cellules nouvellement formées. Des cellules binucléées avec des schizontes situés entre les noyaux ont également été observées. On ne peut tirer aucune conclusion définitive quant au fait de savoir si ces cellules appartiennent à des phases situées dans la division sans mitose, ou si elles sont le résultat de la fusion de cellules infectées. On a noté de larges variations dans le nombre de noyaux des schizontes par cellule infectée, avec une moyenne de 12,2 noyaux par schizonte. La grande majorité des cellules en contenait 4 à 16.
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Pang, Xin-Li, Toshihide Mitamura, and Toshihiro Horii. "Antibodies Reactive with the N-Terminal Domain ofPlasmodium falciparum Serine Repeat Antigen Inhibit Cell Proliferation by Agglutinating Merozoites and Schizonts." Infection and Immunity 67, no. 4 (April 1, 1999): 1821–27. http://dx.doi.org/10.1128/iai.67.4.1821-1827.1999.

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ABSTRACT The serine repeat antigen (SERA) is a vaccine candidate antigen ofPlasmodium falciparum. Immunization of mice withEscherichia coli-produced recombinant protein of the SERA N-terminal domain (SE47′) induced an antiserum that was inhibitory to parasite growth in vitro. Affinity-purified mouse antibodies specific to the recombinant protein inhibited parasite growth between the schizont and ring stages but not between the ring and schizont stages. When Percoll-purified schizonts were cultured with the affinity-purified SE47′-specific antibodies, schizonts and merozoites were agglutinated. Indirect-immunofluorescence assays with unfixed parasite cells showed that SE47′-specific immunoglobulin G (IgG) bound to SERA molecules on rupturing schizonts and merozoites but the IgG did not react with the schizont-infected erythrocytes (RBC). Furthermore, double-fluorescence staining against SE47′-specific IgG and anti-human RBC membrane IgG showed that the RBC membrane disappeared from SE47′-specific-IgG-bound schizonts after cultivation. These observations suggest that the SE47′-specific antibodies inhibit parasite growth by cross-linking SERA molecules that are associated with merozoites in rupturing schizonts with partly broken RBC and parasitophorous vacuole membranes, blocking merozoite release.
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LINDSAY, D. S., J. P. DUBEY, K. M. HORTON, and D. D. BOWMAN. "Development of Sarcocystis falcatula in cell cultures demonstrates that it is different from Sarcocystis neurona." Parasitology 118, no. 3 (March 1999): 227–33. http://dx.doi.org/10.1017/s003118209800376x.

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The development of Sarcocystis falcatula merozoites in bovine turbinate (BT) cell cultures is described and compared with development of Sarcocystis neurona merozoites. Merozoites of S. falcatula entered BT cell cultures and increased in size until 3 days post-inoculation when the nucleus of some merozoites developed lobes. Developing schizonts present at 4 days contained a lobed nucleus or appeared multinucleate. A single mature schizont was observed 4 days p.i. Schizonts were numerous 5 and 6 days p.i. Merozoites were produced from blastophores on the schizont. S. neurona merozoites developed to mature schizonts by 3 days p.i. in BT cells and a residual body was often present. Transmission electron microscopy revealed that S. falcatula merozoites possessed more micronemes than did S. neurona merozoites. Our study demonstrates that S. falcatula and S. neurona are not the same parasite.
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Khoury, David S., Deborah Cromer, Shannon E. Best, Kylie R. James, Peter S. Kim, Christian R. Engwerda, Ashraful Haque, and Miles P. Davenport. "Effect of Mature Blood-Stage Plasmodium Parasite Sequestration on Pathogen Biomass in Mathematical andIn VivoModels of Malaria." Infection and Immunity 82, no. 1 (October 21, 2013): 212–20. http://dx.doi.org/10.1128/iai.00705-13.

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ABSTRACTParasite biomass and microvasculature obstruction are strongly associated with disease severity and death inPlasmodium falciparum-infected humans. This is related to sequestration of mature, blood-stage parasites (schizonts) in peripheral tissue. The prevailing view is that schizont sequestration leads to an increase in pathogen biomass, yet direct experimental data to support this are lacking. Here, we first studied parasite population dynamics in inbred wild-type (WT) mice infected with the rodent species of malaria,Plasmodium bergheiANKA. As is commonly reported, these mice became moribund due to large numbers of parasites in multiple tissues. We then studied infection dynamics in a genetically targeted line of mice, which displayed minimal tissue accumulation of parasites. We constructed a mathematical model of parasite biomass dynamics, incorporating schizont-specific host clearance, both with and without schizont sequestration. Combined use of mathematical andin vivomodeling indicated, first, that the slowing of parasite growth in the genetically targeted mice can be attributed to specific clearance of schizonts from the circulation and, second, that persistent parasite growth in WT mice can be explained solely as a result of schizont sequestration. Our work provides evidence that schizont sequestration could be a major biological process driving rapid, early increases in parasite biomass during blood-stagePlasmodiuminfection.
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Spooner, P. R. "The effects of oxytetracycline on Theileria parva in vitro." Parasitology 100, no. 1 (February 1990): 11–17. http://dx.doi.org/10.1017/s0031182000060066.

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SummaryWhen bovine peripheral blood leucocytes were infected with Theileria parva sporozoites, immediate treatment with oxytetracycline (OTC) inhibited the development of sporozoites to mature schizonts. The extent of inhibition was dependent on drug concentration and duration of treatment. Concentrations of 5 μg/ml OTC, or higher, for 8 days completely inhibited the establishment of schizonts and their ability to transform host cells. A cytostatic effect on schizont-infected cell lines was found with three tetracyclines and was also demonstrated on uninfected lymphoblasts. The parasites were found to be sensitive t OTC during development to schizonts, but when mature and established within host cells, schizonts were not demonstrably affected. The infectivity of sporozoites and the binding of sporozoites to lymphocytes were not directly inhibited by OTC. The results may explain the action of tetracyclines when used prophylactically during immunization against East Coast fever, and also the reasons for the ineffectiveness of these drugs when used therapeutically during patent disease.
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LaDouceur, Elise E. B., Judy St Leger, Alexandria Mena, Ashley Mackenzie, Jacob Gregg, Maureen Purcell, William Batts, and Paul Hershberger. "Ichthyophonus sp. Infection in Opaleye (Girella nigricans)." Veterinary Pathology 57, no. 2 (February 21, 2020): 316–20. http://dx.doi.org/10.1177/0300985819900015.

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Over a 3-year-period, 17 wild-caught opaleye ( Girella nigricans) housed in a public display aquarium were found dead without premonitory signs. Grossly, 4 animals had pinpoint brown or black foci on coelomic adipose tissue. Histologically, liver, spleen, heart, and posterior kidney had mesomycetozoan granulomas in all cases; other organs were less commonly infected. Four opaleye had goiter; additional substantial lesions were not identified. Granulomas surrounded melanized debris, leukocytes, and mesomycetozoa represented by folded membranes (collapsed schizont walls), intact schizonts (50- to >200 µm in diameter with a multilaminate membrane), plasmodia (budding from schizonts or free in tissue), or rarely germinal tubes (budding from schizonts). Ichthyophonus was grown from fresh tissues in tissue explant broth cultures of the heart, liver, and/or spleen. Polymerase chain reaction using 18S ribosomal DNA primers amplified a 1730-bp region, and the DNA sequence was most similar to Ichthyophonus hoferi, which is often associated with freshwater aquaculture fish.
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SILVESTRINI, F., P. ALANO, and J. L. WILLIAMS. "Commitment to the production of male and female gametocytes in the human malaria parasite Plasmodium falciparum." Parasitology 121, no. 5 (November 2000): 465–71. http://dx.doi.org/10.1017/s0031182099006691.

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Commitment to the production of female and male gametocytes was studied in the NF54 line of the human malaria parasite Plasmodium falciparum. The development of sibling parasites derived from individual schizonts was followed, and 2 antisera against the female gametocyte-specific protein Pfg377 and the male gametocyte-specific protein α-tubulin II were used to determine the sex of sibling gametocytes. The experiment showed that individual cohorts of sibling gametocytes were stained in a mutually exclusive fashion by only one or the other antiserum, indicating that individual schizonts committed to yield sexual parasite progeny produce gametocytes of the same sex. This work suggests that in P. falciparum commitment to sexual differentiation occurs prior to schizont maturation, at the same moment when the sex of the resulting gametocytes is determined.
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Waterfall, Martin, Antony Black, and Eleanor Riley. "γδ+ T Cells Preferentially Respond to Live Rather than Killed Malaria Parasites." Infection and Immunity 66, no. 5 (May 1, 1998): 2393–98. http://dx.doi.org/10.1128/iai.66.5.2393-2398.1998.

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ABSTRACT We have compared the in vitro responses of peripheral blood T cells from malaria-unexposed donors to live Plasmodium falciparumschizonts, freeze-thawed schizont extracts (P. falciparumschizont extracts [PfSE]), and parasite culture supernatants. We show that the cells responding to PfSE and parasite culture supernatants are predominantly CD4+ TCRαβ+ while in the presence of live schizonts there is an additional activation of TCRγδ+ cells. Activation of TCRγδ+cells in response to PfSE was seen only when irradiated autologous feeder cells or recombinant interleukin-2 (IL-2) was added to the cultures. Live schizonts but not PfSE induced significant IL-2 production in vitro in the first 5 days after stimulation, suggesting that induction of early IL-2 by live parasites may contribute to the marked activation of the TCRγδ+ population.
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Smeijsters, L. J., N. M. Zijlstra, F. F. Franssen, and J. P. Overdulve. "Simple, fast, and accurate fluorometric method to determine drug susceptibility of Plasmodium falciparum in 24-well suspension cultures." Antimicrobial Agents and Chemotherapy 40, no. 4 (April 1996): 835–38. http://dx.doi.org/10.1128/aac.40.4.835.

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An in vitro test which quantifies drug inhibition of Plasmodium falciparum replication by measuring the fluorescence intensity of Hoechst 33258 dye bound to DNA is described. The procedure does not require expensive reagents or equipment and can be completed in less than 10 min. The assay was highly accurate and sensitive: cultures with as few as 0.4% schizont-infected erythrocytes could reliably be analyzed. The method was not biased by the actual parasite stage used; i.e., the amount of fluorescence detected in a sample of a culture of mature schizonts equaled the amount detected with the ring form culture derived from these schizonts. Even the presence of large proportions of free merozoites, which are easily neglected in microscopic estimates, did not bias the results. Furthermore, measurement of the chloroquine susceptibility of the multidrug-resistant K1 strain and the chloroquine-susceptible NF54 strain showed that the method is most suitable for quantifying the drug resistance of P. falciparum.
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Stephen W. Carmichael and Jon E. Rosenblatt. "Imaging New Paths for Malarial Parasites." Microscopy Today 14, no. 4 (July 2006): 3–5. http://dx.doi.org/10.1017/s1551929500050215.

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In general terms, parasites that cause malaria are injected into the skin by mosquitoes. They then travel into the bloodstream and then to the liver where they invade liver cells and mature into forms called schizonts. Within each schizont, cell division produces thousands of tiny new forms called merozoites, each of which, when released into the bloodstream, is capable of infecting a red blood cell. This “traditional” pathway for malarial parasites may not be the only way these parasites travel through the body. Using some increasingly more powerful immuno-imaging tools, Rogerio Amino, Sabine Thiberge, Béatrice Martin, Susanna Celli, Spencer Shorte, Friedrich Frischknecht, and Robert Ménard have demonstrated an additional route that could have profound implications for developing effective vaccines for this major worldwide disease.
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Dissertations / Theses on the topic "Schizonte"

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MELLOUK-PIMONT, SYLVIE. "Cultures des stades hepatiques de plasmodies de mammiferes : applications du modele in-vitro." Paris 7, 1987. http://www.theses.fr/1987PA077276.

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Mise au point d'un modele in vitro pour l'etude du cycle hepatique d'especes plasmodiales pathogenes pour l'homme utilisant des cultures d'hepatocytes humains. Evaluation des facteurs interferant avec le developpement du schizonte hepatique. Application du modele a la prediction de l'efficacite de la reponse immune anti-proteine circumsporozoite (pv): evaluation de l'effet biologique d'anticorps specifiques des sequences repetes de pc, d'anticorps induits chez l'homme par immunisation par des sporozoites, et de cytokines. Etude de la composition antigenique du schizonte hepatique in vitro
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De, Aguiar J. C. S. "Studies on the polymorphic schizont antigen of Plasmodium chabaudi." Thesis, Open University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383640.

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Chai, Zhong-wei. "Identification and characterization of secreted proteins of Theileria lestoquardi schizonts." Thesis, University of Edinburgh, 2005. http://hdl.handle.net/1842/30104.

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T. lestoquardi is an important tick-borne parasite that infects leukocytes of sheep and goats. The disease is mainly caused by the schizont stage which induces transformation of the infected cell to a state of uncontrolled proliferation. The purpose of this study was to identify schizont secreted proteins, which are likely to include molecules targeted by the immune response as well as those associated with the transformation process. An efficient method for the lysis and purification of schizonts from infected cells was established. This involved use of complement treatment to release schizonts from infected cells and an optimal density of Nycoprep gradient medium to separate schizonts from host cell components. An optimised method for metabolic labelling of schizont-infected cells was also established. Putative secreted proteins were detected from metabolically labelled schizont culture supernatants by SDS-PAGE and autoradiographic analysis. Using two-dimensional electrophoresis, mass spectrometry, including MALDI­TOF and Q-TOF, and N-terminal sequencing analysis, three putative secreted proteins of parasite origin were identified, namely Theileria mhsp70 (TLS3), hsp70 (TLS15) and inorganic pyrophosphatase (TLS16). Seven host-derived proteins were also identified, namely mhsp70 (TLSl), hsp60 (TLS2), mitochondrial ribosomal protein L12 (MRPL12, TLS4), ATP synthase-d (TLS5), ATP synthase 6(TLSll), PDH-Elb (TLS12) and A TP-dependent proteinase SP-22 (TLS13). Further investigation of the relationship of the host-derived proteins with the schizont using dual-labelling and confocal microscopy analysis provided evidence that the host-derived protein, MRPL12, is associated with intracellular schizonts with some co-localising with schizont mitochondria. The analysis also revealed that some host mitochondria are closely associated with the schizonts of T. lestoquardi.
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Mohd, Abd Razak M. R. B. "Investigating GAP45 localisation and phosphorylation during Plasmodium falciparum schizont development." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1354933/.

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The invasion of erythrocytes by merozoites is driven by an actomyosin motor assembled below the parasite’s plasma membrane, with the myosin anchored on the inner membrane complex (IMC). The myosin (MyoA) is within a protein complex that is comprised of several proteins including myosin tail domain interacting protein (MTIP) and glideosome associated proteins (GAP) 45 and 50. A ternary complex of MyoA, MTIP and GAP45 is formed and later associates with GAP50. GAP45 is acylated by both myristoyl- and palmitoyl-fatty acids and is phosphorylated. This study has highlighted the GAP45 phosphorylation by calcium dependent protein kinase 1 (CDPK1) in vitro and its possible roles in schizogony. By site directed mutagenesis, substitution of S31, S89, S103 and S156 to alanine decreased the level of GAP45 phosphorylation, with S103A exhibiting a major decrease in 32P incorporation. Phosphorylation on S89 and S103 was studied further in parasites as both residues were among the phospho-sites in phosphopeptides identified in vivo. This study also showed that full length GAP45 labelled internally with GFP (FL-GAP45) is assembled into the motor complex, phosphorylated and transported to the developing IMC in early schizogony, where it accumulates during intracellular development until merozoite release. The C-terminal truncated GFP-GAP45 (N-GAP45; residues 1-29) localised at the plasma membrane instead of the IMC and was not assembled into the motor complex. The N-terminal truncated GFP-GAP45 (C-GAP45; residues 30-205) behaved like FL-GAP45. Modifying serine residues, S89 and S103, in GAP45 with alanine or aspartate had no apparent effect on its assembly into the protein complex or its intracellular location during schizont development and merozoite maturation. A second highly phosphorylated component of the complex (GAP40) was also identified. The early assembly of the motor complex suggests that it has functions in addition to its role in erythrocyte invasion.
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Farouk, Salah Eldin. "T cell and antibody responses in Plasmodium falciparum malaria and their relation to disease susceptibility." Doctoral thesis, Stockholm : Wenner-Grens institut för experimentell biologi, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-320.

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Alshahrani, Mohammed A. S. "Oral and nasal infectivity and immunogenicity of Plasmodium berghei and yoelii sporozoites and longevity of Plasmodium falciparum trophozoites and schizonts." Thesis, Bangor University, 2017. https://research.bangor.ac.uk/portal/en/theses/oral-and-nasal-infectivity-and-immunogenicity-of-plasmodium-berghei-and-yoelii-sporozoites-and-longevity-of-plasmodium-falciparum-trophozoites-and-schizonts(69df2a18-9a6d-4ee5-922d-bb11332f86f0).html.

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Malaria is one of the most problematic diseases that human being has ever confronted. The quest for an effective, robust vaccine has been going on for more than a century. The whole Plasmodium sporozoites vaccine strategy has proven to be the best approach for eliciting up to 70% protection and for up to 6 months after the last immunization. Most of the robust vaccines that we have nowadays against several microbiological organisms are given by either oral or nasal routes. Infectivity and immunogenicity of Plasmodium berghei ANKA and P. yoelii Nigeriensis sporozoites have never been tested against BALB/c or C57BL/6 mice after being inoculated via oral and nasal routes. Results of this study show that inoculation of sporozoites of the species P. berghei or P. yoelii into BALB/c or C57BL/6 mice are infective and immunogenic. Furthermore, there was a cross-reactivity between the two parasite species when tested against several synthetic peptides. These findings shed light on the importancy of the oral and nasal canal as routes for experimentations of the immunization regime. The large subunit vaccines development concentrated on the erythrocytic stage of malaria parasites has generated disappointing results, Therefore, there is currently a renewed focus on the whole Plasmodium blood stage parasite. In the current study, we aim to assess whether it is possible to obtain a living, whole entity of the blood stage that can be kept alive under minimal conditions and ideally without cryopreservation which could be used in developing countries a live, whole organism blood stage vaccine. we examined the viability as well as the invasiveness potency of Plasmodium falciparum parasites after being isolated from RBCs and incubated at 37˚C and RT. We showed here that the Plasmodium parasites were able to retain their invasiveness for 16 days despite being incubated at far lower temperature (at RT) than the optimal temperature. Also we showed that the Plasmodium falciparum at late trophozoites and early schizonts were capable to remain viable for 10 months (nearly 300 days) outside the RBCs at RT. The diversity of malaria disease in animals is larger ecologically and systematically than we commonly expected. The Plasmodium genus is a member within the order Haemosporidia, is consider one of the largest genus in this order, and currently encompass more than 250 Plasmodium species. Most of these species have only been defined morphologically. Most animals show simultaneous infections with more than one species of Plasmodium and most species descriptions originated from such multiple infections, which prevents the molecular characterization of most Plasmodium species as sequence data cannot be assigned to particular morphospecies. We have successfully developed genus- and species-specific FISH probes based on the small and large ribosomal subunit for Plasmodium falciparum as a proof of concept for the interrogation of animal morphospecies of Plasmodium parasites. This will open up the future for molecular screening of animal malaria, not only in blood samples but also in fecal samples, and might lead to a better understanding of the epidemiology and ecology of malaria parasites in many animal species in temperate and in tropical regions.
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Darghouth, Mohamed Aziz. "La theileriose tropicale des bovins (Theileria annulata) en tunisie : caractérisation des états d'endémie et deloppemnt de lignées de schizontes attebues." Toulouse, INPT, 2000. http://www.theses.fr/2000INPT016A.

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La première partie de ce travail est une revue bibliographique sur Theileria annulata et la theilériose tropicale, où les particularités de cette protozoose en Tunisie sont présentées. La deuxième partie, expérimentale, est divisée en deux chapitres. Le premier chapitre présente les résultats d'enquête séro-épidémiologiques sur la theilériose dans les élevages des zones bioclimatiques sud-humide et semi-aride. Trois états d'endémie ont été identifiés en Tunisie : un état d'endémie stable dans moins de 5% des étables étudiées, et deux états d'endémie instable : modérée et élevée. L'endémie instable modérée existe dans près de 20% des étables et se caractérise par des risques potentiels maximaux de theilériose tropicale chez les bovins en 2ème et 3ème saison estivale. L'instabilité élevée est rencontrée dans 75% environ des élevages, associée à des risques maximaux de maladie chez les vaches laitières de 4 saisons estivales et plus. Les implications de ces données dans le choix de souches atténuées vaccinales et l'élaboration d'une stratégie de vaccination de masse sont discutées. Le deuxième chapitre décrit l'atténuation de trois lignées parasitaires autochtones de T. Annulata en culture cellulaire à long terme de leucocytes infectés par des schizontes. L'atténuation de trois lignées parasitaires autochtones de T. Annulata en culture cellulaire à long terme de leucocytes infectés par des schizontes. L'atténuation est associée à une restriction du polymorphisme parasitaire. L'immunité conférée par ces lignées atténuées envers des infections d'épreuve hétérologues létale et sub-létale a été évalué à 30 jours et à six mois de la vaccination, elle s'est avérée moins solide qu'avec les lignées parentales non atténuées. Le phénotypage des leucocytes infectés par des schizontes en culture e révélé qu'il s'agissait principalement de cellules macrophagiques monocytaires et secondairement de lymphocytes B. L'atténuation est associée à une hyper-expression du marqueur CD25 (récepteur alpha de l'interleukine 2) régulée par le parasite et maintenue après réplication sexué chez la tique, et à une expression réduite du marqueur bovin CD9 like. La transmission aux tiques vecteurs a été testée en conditions expérimentales pour deux des trois lignées atténuées. L'une d'entre elles a été transmise de façon répétée à des tiques Hyalomma anatolicum excavatum associée à un phénomène de ré-expression de virulence. Ces différents résultats sont discutés en insistant sur leurs implications pour le développement et l'utilisation d'un vaccin vivant atténué contre la theilériose tropicale en Tunisie.
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OUARZANE, MERYEM. "Etude des premiers stades de developpement de la coccidie aviaire eimeria tenella : clonage et expression de genes de schizontes primaires (doctorat microbiologie)." Paris 11, 1998. http://www.theses.fr/1998PA114824.

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Hedlund, Johanna. "Vad kan schizot lära Freud? : Om Deleuze och Guattaris kritik av Freud, och det mångfaldiga subjektet." Thesis, Södertörns högskola, Filosofi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-30978.

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Deleuze and Guattaris extensive critique of psychoanalysis is clearly demonstrated in their reading of Freuds famous case study The Wolfman. This paper aims to examine this critique, addressed in the chapter One or Several Wolves? of A Thousand Plateaus. The aim is to illustrate an alternative view of the subject to the one presented by Freud. Freuds's method is understanding the self by interpreting the unconscious as seen from the analyst's perspective. This paper seeks to present a different approach by regarding the unconscious as productive and collective. This description of the self formulate alternative suggestions as to how to treat mental illness. The paper uses the anti-psychiatric clinic La Borde as an example of this in practice.
Deleuze och Guattaris omfattande kritik av psykoanalysen framgår tydligt i deras läsning av Freuds fallstudie av Vargmannen. I Tusen Platåer kapitlet ”En eller flera vargar?” behandlas kritiken som denna uppsats syftar till att undersöka. Uppsatsen belyser kritiken med avsikten att öppna för en annan syn på subjektet än den Freud förmedlar. Freuds metod är att utifrån en analytikers position förstå jaget genom att tolka det omedvetna. Den här uppsatsen syftar till att framhålla ett annat förhållningssätt till jaget med ingången att det omedvetna ses som produktivt och kollektivt. Denna subjektsbeskrivning föreslår en alternativ behandling av psykiskt sjuka. I uppsatsen används den antipsykiatriska kliniken La Borde för att exemplifiera detta i praktiken.
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Benade, Justin Armand. "Immunization of roan antelope (Hippotragus equinus) using in vitro cultured Theileria species (sable) schizonts." Diss., 2010. http://hdl.handle.net/2263/30503.

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Theileria species (sable) causes significant mortalities in roan (Hippotragus equinus), and to a lesser extent, sable antelope (Hippotragus niger) yearly. Treatment of the condition and an ‘infect and treat’ vaccination method using a tick-derived stabilate both rely on the availability of buparvaquone, a naphthoquinone with anti-theilerial activity. As buparvaquone is a controlled drug which is not commercially available in South Africa, a viable commercial alternative prevention or treatment method is necessary to control this disease. This study explores the effectiveness of an alternative vaccination method using Theileria sp. (sable) infected in vitro cultured leukoblasts. A Theileria sp. (sable) containing cell line was initiated from lymph node biopsy material of an infected roan antelope and the parasite was successfully propagated in vitro. Attenuation is believed to have been achieved by 16 cycles of passage. Real time PCR suggests that the parasite was successfully transmitted via subcutaneous inoculation with this cell line to two naïve roan antelope. These two inoculated animals remained clinically unaffected by challenge with a tick stabilate used in the ‘infect and treat’ vaccination method. In contrast, the two unvaccinated control animals became clinically ill and required buparvaquone treatment after challenge. This pilot study provides enough evidence to encourage further investigation in the use of Theileria sp. (sable) infected cells as a potential vaccine. A field study involving more animals which are challenged by natural infection after inoculation is the proposed next step.
Dissertation (MMedVet)--University of Pretoria, 2010.
Paraclinical Sciences
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Books on the topic "Schizonte"

1

Gardikas, K. D. Schizontas ta chartia mou--. Athēna: Ekdoseis Philippotē, 1987.

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V, Tsaras Geōrgios, Moutsopoulos Thanasēs, and Kratiko Mouseio Synchronēs Technēs (Greece), eds. Eikastiko panorama stēn Hellada 2006: Dia schizontas ta horia. Thessalonikē: Kratiko Mouseio Synchronēs Technēs, 2006.

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Book chapters on the topic "Schizonte"

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Baum, H. "Schizont." In Springer Reference Medizin, 2120. Berlin, Heidelberg: Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_2761.

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Baum, H. "Schizont." In Lexikon der Medizinischen Laboratoriumsdiagnostik, 1. Berlin, Heidelberg: Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-49054-9_2761-1.

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Sprey, A. "De schizoïde persoonlijkheidsstoornis." In Praktijkboek persoonlijkheidsstoornissen, 183–99. Houten: Bohn Stafleu van Loghum, 2002. http://dx.doi.org/10.1007/978-90-313-6515-9_5.

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Sprey, Adriaan. "De schizoïde persoonlijkheidsstoornis." In Praktijkboek persoonlijkheidsstoornissen, 195–220. Houten: Bohn Stafleu van Loghum, 2015. http://dx.doi.org/10.1007/978-90-368-0570-4_5.

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Ogden, Thomas H. "Die schizoide Position." In Frühe Formen des Erlebens, 85–110. Vienna: Springer Vienna, 2000. http://dx.doi.org/10.1007/978-3-7091-6790-8_4.

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Gordon, Caryn, and Neil J. Skolnick. "Paranoid-schizoide Position." In Wörterbuch der Psychotherapie, 497. Vienna: Springer Vienna, 2000. http://dx.doi.org/10.1007/978-3-211-99131-2_1326.

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Ogden, Thomas H. "Die schizoide Position." In Frühe Formen des Erlebens, 85–110. Vienna: Springer Vienna, 1995. http://dx.doi.org/10.1007/978-3-7091-3342-2_4.

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Sprey, Adriaan. "De schizoïde persoonlijkheidsstoornis." In Praktijkboek persoonlijkheidsstoornissen, 195–220. Houten: Bohn Stafleu van Loghum, 2015. http://dx.doi.org/10.1007/978-90-368-1760-8_5.

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Albert Gutiérrez, Juan José. "Der schizoide Charakter:Enneatyp 5." In Zärtlichkeit und Aggressivität, 113–53. Wiesbaden: Springer Fachmedien Wiesbaden, 2015. http://dx.doi.org/10.1007/978-3-658-08510-0_4.

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Braks, Joanna, Elena Aime, Roberta Spaccapelo, Onny Klop, Chris J. Janse, and Blandine Franke-Fayard. "Bioluminescence Imaging of P. berghei Schizont Sequestration in Rodents." In Methods in Molecular Biology, 353–68. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-026-7_25.

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Conference papers on the topic "Schizonte"

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Haryanto, S. Edy Victor, M. Y. Mashor, A. S. Abdul Nasir, and H. Jaafar. "A fast and accurate detection of Schizont plasmodium falciparum using channel color space segmentation method." In 2017 5th International Conference on Cyber and IT Service Management (CITSM). IEEE, 2017. http://dx.doi.org/10.1109/citsm.2017.8089290.

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Dyah Retno Lastuti, Nunuk, Endang Suprihati, Dony Chrismanto, and Anwar Ma’ruf. "Antigenic Protein of Leucocytozoon caulleryi schizont Inducing Cellular Immune Response: TLR-2 and CD4 as Marker." In 1st International Conference Postgraduate School Universitas Airlangga : "Implementation of Climate Change Agreement to Meet Sustainable Development Goals" (ICPSUAS 2017). Paris, France: Atlantis Press, 2018. http://dx.doi.org/10.2991/icpsuas-17.2018.16.

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Fedosov, Dmitry A., Bruce Caswell, and George Em Karniadakis. "Multiscale Modeling of Blood Flow in Cerebral Malaria." In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13012.

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Abstract:
Healthy red blood cells (RBCs) have relatively soft membranes that allow them to pass through narrow capillaries of the diameter as small as 3 μm. Recent experiments [1] showed that malaria-parasitized RBCs are characterized by a considerable stiffening of their membranes compared to healthy RBCs. This results in an increased blood flow resistance in the capillary bed, and may lead to an obstruction of small capillaries and significant blood-flow reduction. In addition, malaria-infected cells are able to adhere to each other and endothelium in arterioles and venules leading to more severe blood-flow reduction or blockage. Blood flow in cerebral malaria is extremely complex due to the mentioned effects, and requires multiscale modeling of RBCs and adhesive interactions. We developed a coarse-grained RBC model which is able to accurately reproduce RBCs mechanics and dynamics for different malaria stages: ring-trophozoite-schizont from the earliest to the latest. RBC adhesion is simulated based on the stochastic bond formation/dissociation model, which is able to capture complex adhesive dynamics.
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