Academic literature on the topic 'Schizonticide activity'

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Journal articles on the topic "Schizonticide activity"

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Andersen, S. L., P. McGreevy, B. G. Schuster, et al. "Activity of Azithromycin as a Blood Schizonticide against Rodent and Human Plasmodia In Vivo." American Journal of Tropical Medicine and Hygiene 52, no. 2 (1995): 159–61. http://dx.doi.org/10.4269/ajtmh.1995.52.159.

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Fonte, Mélanie, Natália Tassi, Paula Gomes, and Cátia Teixeira. "Acridine-Based Antimalarials—From the Very First Synthetic Antimalarial to Recent Developments." Molecules 26, no. 3 (2021): 600. http://dx.doi.org/10.3390/molecules26030600.

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Malaria is among the deadliest infectious diseases in the world caused by Plasmodium parasites. Due to the high complexity of the parasite’s life cycle, we partly depend on antimalarial drugs to fight this disease. However, the emergence of resistance, mainly by Plasmodium falciparum, has dethroned most of the antimalarials developed to date. Given recent reports of resistance to artemisinin combination therapies, first-line treatment currently recommended by the World Health Organization, in Western Cambodia and across the Greater Mekong sub-region, it seems very likely that artemisinin and i
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Ferrara, Luciana, and Srinivas G. "Bioequivalence of two quinidine gluconate 324mg extended release formulations in healthy Brazilian volunteers under fed conditions: a pilot study." International Journal of Basic & Clinical Pharmacology 7, no. 7 (2018): 1238. http://dx.doi.org/10.18203/2319-2003.ijbcp20182405.

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Background: Quinidine is an antimalarial schizonticide and an antiarrhythmic agent with Class Ia activity. The present study was aimed at analyzing the bioequivalence of the proposed generic product Quinidine Gluconate 324mg Extended Release Tablets with the marketed product of Sun pharmaceuticals, USA.Methods: The design was an open, longitudinal, randomized, comparative study of two formulations in single dose of 324 mg, with a 5 days washout in between doses. The study was conducted in 12 healthy adult male and female Brazilian volunteers under fed conditions in Azidus Brasil, Valinhos, Bra
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Birrell, Geoffrey W., Matthew P. Challis, Amanda De Paoli, et al. "Multi-omic Characterization of the Mode of Action of a Potent New Antimalarial Compound, JPC-3210, Against Plasmodium falciparum." Molecular & Cellular Proteomics 19, no. 2 (2019): 308–25. http://dx.doi.org/10.1074/mcp.ra119.001797.

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The increasing incidence of antimalarial drug resistance to the first-line artemisinin combination therapies underpins an urgent need for new antimalarial drugs, ideally with a novel mode of action. The recently developed 2-aminomethylphenol, JPC-3210, (MMV 892646) is an erythrocytic schizonticide with potent in vitro antimalarial activity against multidrug-resistant Plasmodium falciparum lines, low cytotoxicity, potent in vivo efficacy against murine malaria, and favorable preclinical pharmacokinetics including a lengthy plasma elimination half-life. To investigate the impact of JPC-3210 on b
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Dow, Geoffreym S., James A. Reynoldson, and R. C. Andrew Thompson. "Plasmodium berghei: A New Rat Model for Assessment of Blood Schizonticidal Activity." Experimental Parasitology 93, no. 2 (1999): 92–94. http://dx.doi.org/10.1006/expr.1999.4433.

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Tan-ariya, P., K. Na-Bangchang, R. Ubalee, S. Boutes, S. Riengchainam, and J. Karbwang. "In vitro blood schizonticidal activity of sera containing mefloquine-quinine against Plasmodium falciparum." Tropical Medicine and International Health 2, no. 2 (1997): 159–64. http://dx.doi.org/10.1046/j.1365-3156.1997.d01-243.x.

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Kuhen, Kelli L., Arnab K. Chatterjee, Matthias Rottmann, et al. "KAF156 Is an Antimalarial Clinical Candidate with Potential for Use in Prophylaxis, Treatment, and Prevention of Disease Transmission." Antimicrobial Agents and Chemotherapy 58, no. 9 (2014): 5060–67. http://dx.doi.org/10.1128/aac.02727-13.

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ABSTRACTRenewed global efforts toward malaria eradication have highlighted the need for novel antimalarial agents with activity against multiple stages of the parasite life cycle. We have previously reported the discovery of a novel class of antimalarial compounds in the imidazolopiperazine series that have activity in the prevention and treatment of blood stage infection in a mouse model of malaria. Consistent with the previously reported activity profile of this series, the clinical candidate KAF156 shows blood schizonticidal activity with 50% inhibitory concentrations of 6 to 17.4 nM agains
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Ezedom, Theresa, Olukemi Opajobi, Innocent Onyesom, and Lilian Chris-Ozoko. "Blood Schizonticidal Activity of Phyllanthus amarus Enhances Testovarian Antioxidant Defense Capacity in Plasmodium berghei Infected Mice." Tropical Journal of Natural Product Research 2, no. 3 (2018): 150–57. http://dx.doi.org/10.26538/tjnpr/v2i3.10.

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Belay, Wubetu Yihunie, Abyot Endale Gurmu, and Zewdu Birhanu Wubneh. "Antimalarial Activity of Stem Bark of Periploca linearifolia during Early and Established Plasmodium Infection in Mice." Evidence-Based Complementary and Alternative Medicine 2018 (2018): 1–7. http://dx.doi.org/10.1155/2018/4169397.

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Background. In Ethiopia, stem bark of Periploca linearifolia is used for the treatment of malaria by the local community and demonstrated antimalarial activity in vitro. Despite its in vitro antimalarial activity, no scientific study has been carried out to verify its activity in vivo. Therefore, the aim of the study was to evaluate the antimalarial activity of Periploca linearifolia stem bark extract in mice. Methods. The dried stem bark of Periploca linearifolia was extracted with 80% methanol and evaluated for its antimalarial activity on both early and established Plasmodium berghei infect
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Osunkwo, UA, GC Akuodor, Maryam Idris-Usman, TheresaC Ugwu, JL Akpan, and SI Ghasi. "In vivo schizonticidal activity of ethanolic leaf extract of gongronema latifolium on plasmodium berghei berghei in mice." Ibnosina Journal of Medicine and Biomedical Sciences 2, no. 3 (2010): 118. http://dx.doi.org/10.4103/1947-489x.210981.

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Dissertations / Theses on the topic "Schizonticide activity"

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Oliveira, Aline Mylena Guedes da Costa. "Avalia??o da atividade antimal?rica e citot?xica de plantas medicinais dos Biomas Caatinga e Amaz?nico." Universidade Federal do Rio Grande do Norte, 2011. http://repositorio.ufrn.br:8080/jspui/handle/123456789/13074.

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Made available in DSpace on 2014-12-17T14:10:24Z (GMT). No. of bitstreams: 1 AlineMGCO_DISSERT.pdf: 3644884 bytes, checksum: e2e3e578d2fb797531853d76567fdc2b (MD5) Previous issue date: 2011-03-15<br>Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico<br>Resistance of Plasmodium falciparum to the usual antimalarials, as well as their adverse effects and high cost, has led to the search of new drugs against malaria. Several of these have been developed from medicinal plants based on ethnopharmacology, including the most widely used antimalarials today: quinine and artemisinin. In the
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