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Journal articles on the topic 'Schizophrenia Spectrum Disorders (SSDs)'

Author: Grafiati

Published: 2 November 2024

Last updated: 31 July 2025

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1

Wu, Sally, Kristoffer J. Panganiban, Jiwon Lee, et al. "Peripheral Lipid Signatures, Metabolic Dysfunction, and Pathophysiology in Schizophrenia Spectrum Disorders." Metabolites 14, no. 9 (2024): 475. http://dx.doi.org/10.3390/metabo14090475.

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Metabolic dysfunction is commonly observed in schizophrenia spectrum disorders (SSDs). The causes of metabolic comorbidity in SSDs are complex and include intrinsic or biological factors linked to the disorder, which are compounded by antipsychotic (AP) medications. The exact mechanisms underlying SSD pathophysiology and AP-induced metabolic dysfunction are unknown, but dysregulated lipid metabolism may play a role. Lipidomics, which detects lipid metabolites in a biological sample, represents an analytical tool to examine lipid metabolism. This systematic review aims to determine peripheral l

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Ousley, O. Y., E. Smearman, S. Fernandez-Carriba, et al. "Axis I psychiatric diagnoses in adolescents and young adults with 22q11 deletion syndrome." European Psychiatry 28, no. 7 (2013): 417–22. http://dx.doi.org/10.1016/j.eurpsy.2013.06.002.

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AbstractBackground22q11.2 deletion syndrome (22q11DS) associates with schizophrenia spectrum disorders (SSDs), autism spectrum disorders (ASDs), and other psychiatric disorders, but co-occurrence of diagnoses are not well described.MethodsWe evaluated the co-occurrence of SSDs, ASDs and other axis I psychiatric diagnoses in 31 adolescents and adults with 22q11DS, assessing ASDs using either stringent Collaborative Program for Excellence in Autism (ASD-CPEA) criteria, or less stringent DSM-IV criteria alone (ASD-DSM-IV).ResultsTen (32%) individuals met criteria for an SSD, five (16%) for ASD-CP

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Cho, WooRi, Sung-Wan Kim, Seung-Hee Won, et al. "Effects of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition Criteria Changes for Schizophrenia on Diagnoses of First-Episode Schizophrenia Spectrum Disorders." Psychiatry Investigation 22, no. 2 (2025): 212–17. https://doi.org/10.30773/pi.2024.0078.

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Objective Impact of Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) changes on the criteria for schizophrenia (SZ) has been reported to be minimal in previous studies. However, this could be different in first-episode schizophrenia spectrum disorders (FE-SSDs). We investigated what proportion of patients with FE-SSDs was diagnosed based on the sole presence of bizarre delusions (BDs) or first rank auditory hallucinations (FRAHs). Their alternative diagnosis by the DSM-5 was established and diagnostic stability over 1-year was identified.Methods This was a retrospec

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Oliver, Lindsay, Iska Moxon-Emre, Aristotle Voineskos, and Stephanie Ameis. "M49. BEHAVIOURAL SOCIAL COGNITION IN SCHIZOPHRENIA SPECTRUM DISORDERS IN COMPARISON TO AUTISM SPECTRUM DISORDER: A SYSTEMATIC REVIEW AND META-ANALYSIS." Schizophrenia Bulletin 46, Supplement_1 (2020): S152—S153. http://dx.doi.org/10.1093/schbul/sbaa030.361.

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Abstract Background Schizophrenia spectrum disorders (SSDs) and autism spectrum disorder (ASD) both feature social cognitive deficits, which are highly debilitating. These include lower-level processes (e.g. emotion recognition), thought to be subserved by a frontoparietal mirroring network, and higher-level mentalizing processes (e.g. theory of mind), involving cortical midline and lateral temporal brain regions. Across both disorders, impairments in social cognition persist over time, drive disability, and predict functional outcome. Overlapping symptoms in SSDs and ASD have long been recogn

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Agarwal, Sri Mahavir, Joel Dissanayake, Ofer Agid, et al. "Characterization and prediction of individual functional outcome trajectories in schizophrenia spectrum disorders (PREDICTS study): Study protocol." PLOS ONE 18, no. 9 (2023): e0288354. http://dx.doi.org/10.1371/journal.pone.0288354.

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Schizophrenia spectrum disorders (SSDs) are associated with significant functional impairments, disability, and low rates of personal recovery, along with tremendous economic costs linked primarily to lost productivity and premature mortality. Efforts to delineate the contributors to disability in SSDs have highlighted prominent roles for a diverse range of symptoms, physical health conditions, substance use disorders, neurobiological changes, and social factors. These findings have provided valuable advances in knowledge and helped define broad patterns of illness and outcomes across SSDs. Un

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Palin, A. V. "Psychotherapeutic Potential of Psychoeducation in the Rehabilitation of Patients with Schizophrenia Spectrum Disorders." Counseling Psychology and Psychotherapy 32, no. 3 (2024): 96–115. http://dx.doi.org/10.17759/cpp.2024320306.

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<p><strong>Relevance</strong>. Having arisen in routine psychiatric practice to help a patient with schizophrenia spectrum disorders (SSDs), and then his relatives, in building understanding of the illness and ways of coping with it, psychoeducation not only approved the status of a stand-alone method of therapy, but also proved its effectiveness and expediency of use. Gradually, sдeveral models of psychoeducation emerged: informational, supportive, motivational, and a model of teaching skills to cope with illness. <strong>The aim</strong>. The article contains de

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Springfield, Cassi, Lillian Hammer, Amy Pinkham, et al. "0692 Relationships Between Sleep and Social Cognitive Biases in Schizophrenia-Spectrum and Bipolar Disorders." SLEEP 46, Supplement_1 (2023): A304. http://dx.doi.org/10.1093/sleep/zsad077.0692.

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Abstract Introduction People with schizophrenia-spectrum disorders (SSDs) and bipolar disorders (BDs) experience difficulty with social cognition, or the mental processes that underlie social interactions, but determinants of social cognitive impairment are still under investigation. Research suggests that poor sleep quality is related to reduced social cognitive ability in BDs, but it is unclear if sleep quality is related to social cognition in SSDs and if sleep may be related to different types of social cognition (e.g., emotion recognition, biases) in different ways. This study aimed to ex

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Snethen, PhD, LRT/CTRS, Gretchen, Bryan P. McCormick, PhD, CTRS, and Marieke Van Puymbroeck, PhD, CTRS. "Independence through Community Access and Navigation in adults with schizophrenia spectrum disorders Part 1: Theoretical and practical foundations." American Journal of Recreation Therapy 10, no. 1 (2011): 25–33. http://dx.doi.org/10.5055/ajrt.2011.0004.

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Negative symptoms and cognitive dysfunction are two symptomatic categories of schizophrenia spectrum disorders (SSDs) that significantly impair functioning. Treatment for adults with SSDs continues to focus primarily on medication adherence and positive symptom reduction, despite the fact that medication has little impact on negative and cognitive symptoms within this population and, thus, little impact on improving community functioning. This two-part series presents an intervention developed to increase community participation in adults with SSDs. This article presents a comprehensive descri

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Bartoli, F., A. Calabrese, F. Moretti, et al. "The relationship between depression and overall, general psychopathology, positive, and negative symptoms in people with schizophrenia spectrum disorders: a cross-sectional study." European Psychiatry 67, S1 (2024): S387—S388. http://dx.doi.org/10.1192/j.eurpsy.2024.797.

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IntroductionDepressive symptoms are a common occurrence in people suffering from schizophrenia spectrum disorders (SSDs), representing a separate domain that interacts in peculiar ways with positive and negative symptoms. Nonetheless, available evidence on the relationship between depression and key clinical dimensions of SSDs is limited.ObjectivesTo increase the knowledge regarding depression in SSDs, we performed a cross-sectional study aimed to investigate the association of depressive symptoms with overall, general psychopathology, positive, and negative symptoms in individuals with SSDs.M

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Gozé, Tudi, and Istvan Fazakas. "Imagination and Self Disorders in Schizophrenia: A Review." Psychopathology 53, no. 5-6 (2020): 264–73. http://dx.doi.org/10.1159/000509488.

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Anomalies of imagination are frequent and handicapping in schizophrenia spectrum disorders (SSDs) but neglected in psychopathology due to the lack of a conceptual framework to model disorders of imagination. Recently, the link between minimal self disorders and pathology of imagination has been emphasized. The aim of the present article is to discuss this initiative by stressing their paradigm drawing on the recent imaginary turn in phenomenological research. Although this field of research is currently very active in philosophy, there are very few translational approaches in psychopathology o

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Pushko, Ye. "PHENOMENOLOGICAL RESEARCH OF IMAGINATION IN SCHIZOPHRENIA SPECTRUM DISORDERS AS A CONCEPTUAL FRAMEWORK FOR UNDERSTANDING PSYCHOTHERAPEUTIC PROCESSES AND RECOVERY STRATEGIES." Psychology and Personality, no. 1 (March 13, 2023): 178–97. http://dx.doi.org/10.33989/2226-4078.2023.1.274746.

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Although imagination abnormalities are frequent and handicapping in schizophrenia spectrum disorders (SSDs), psychopathology lacks a conceptual framework for modeling imagination disorders. Recently, in connection with the “imaginary turn” in phenomenology, translational approaches between philosophy and psychopathology have been sought. The purpose of the article is the presentation and analysis of modern foreign phenomenological studies of imagination in SSDs by a group of researchers headed by A. Rasmussen and J. Parnas, for the possible implementation of the results in domestic practice. T

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Matsumoto, *Yoshihiro, Nobutaka Ayani, Nozomu Oya, et al. "FREQUENCY AND PREDICTORS OF PERIOPERATIVE PSYCHIATRIC SYMPTOM WORSENING IN PATIENTS WITH SCHIZOPHRENIA SPECTRUM DISORDERS." International Journal of Neuropsychopharmacology 28, Supplement_1 (2025): i231—i232. https://doi.org/10.1093/ijnp/pyae059.405.

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Abstract Background Schizophrenia spectrum disorders (SSDs), including schizophrenia, are serious and chronic illness. Schizophrenia patients are two- to three-times more likely to die early than the general population, and disparities in their access to treatment for physical illnesses have been associated with higher mortality rates. However, patients may not receive adequate treatment due to inadequate medical resources in such cases. Factors related to psychiatric symptom worsening in patients with SSDs are unclear. Aims & Objectives we conducted this study to determine the frequency o

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Bassilios, Bridget, Fiona Judd, and Philippa Pattison. "Why don’t people diagnosed with schizophrenia spectrum disorders (SSDs) get enough exercise?" Australasian Psychiatry 22, no. 1 (2013): 71–77. http://dx.doi.org/10.1177/1039856213510575.

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Oliver, Lindsay D., John D. Haltigan, James M. Gold, et al. "Lower- and Higher-Level Social Cognitive Factors Across Individuals With Schizophrenia Spectrum Disorders and Healthy Controls: Relationship With Neurocognition and Functional Outcome." Schizophrenia Bulletin 45, no. 3 (2018): 629–38. http://dx.doi.org/10.1093/schbul/sby114.

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Abstract Background Schizophrenia spectrum disorders (SSDs) often feature social cognitive deficits. However, little work has focused on the factor structure of social cognition, and results have been inconsistent in schizophrenia. This study aimed to elucidate the factor structure of social cognition across people with SSDs and healthy controls. It was hypothesized that a 2-factor model, including lower-level “simulation” and higher-level “mentalizing” factors, would demonstrate the best fit across participants. Methods Participants with SSDs (N = 164) and healthy controls (N = 102) completed

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Brand, Bodyl A., Yudith R. A. Haveman, Franciska de Beer, Janna N. de Boer, Paola Dazzan, and Iris E. C. Sommer. "Antipsychotic medication for women with schizophrenia spectrum disorders." Psychological Medicine 52, no. 4 (2021): 649–63. http://dx.doi.org/10.1017/s0033291721004591.

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AbstractThere are significant differences between men and women in the efficacy and tolerability of antipsychotic drugs. Here, we provide a comprehensive overview of what is currently known about the pharmacokinetics and pharmacodynamics of antipsychotics in women with schizophrenia spectrum disorders (SSDs) and translate these insights into considerations for clinical practice. Slower drug absorption, metabolism and excretion in women all lead to higher plasma levels, which increase the risk for side-effects. Moreover, women reach higher dopamine receptor occupancy compared to men at similar

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Endres, Dominique, Miriam Matysik, Bernd Feige, et al. "Diagnosing Organic Causes of Schizophrenia Spectrum Disorders: Findings from a One-Year Cohort of the Freiburg Diagnostic Protocol in Psychosis (FDPP)." Diagnostics 10, no. 9 (2020): 691. http://dx.doi.org/10.3390/diagnostics10090691.

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Introduction: Secondary schizophrenia spectrum disorders (SSDs) have clearly identifiable causes. The Department for Psychiatry and Psychotherapy at the University Hospital Freiburg has continued to expand its screening practices to clarify the organic causes of SSDs. This retrospective analysis was carried out to analyze whether a comprehensive organic diagnostic procedure could be informative in patients with SSDs. Methods and Participants: The “Freiburg Diagnostic Protocol in Psychosis” (FDPP) included basic laboratory analyses (e.g., thyroid hormones), metabolic markers, pathogens, vitamin

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Matheson, S. L., M. Kariuki, M. J. Green, et al. "Effects of maltreatment and parental schizophrenia spectrum disorders on early childhood social-emotional functioning: a population record linkage study." Epidemiology and Psychiatric Sciences 26, no. 6 (2016): 612–23. http://dx.doi.org/10.1017/s204579601600055x.

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Aims.Childhood maltreatment and a family history of a schizophrenia spectrum disorder (SSD) are each associated with social-emotional dysfunction in childhood. Both are also strong risk factors for adult SSDs, and social-emotional dysfunction in childhood may be an antecedent of these disorders. We used data from a large Australian population cohort to determine the independent and moderating effects of maltreatment and parental SSDs on early childhood social-emotional functioning.Methods.The New South Wales Child Development Study combines intergenerational multi-agency data using record link

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Adams, MS, CTRS, C-IAYT, Emilie V., and Jasmine Townsend, PhD, CTRS. "A systematic review of yoga and schizophrenia spectrum disorders: Implications for recreational therapy practitioners." American Journal of Recreation Therapy 17, no. 2 (2018): 37. http://dx.doi.org/10.5055/ajrt.2018.0160.

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Schizophrenia spectrum disorders (SSDs) are a group of mental illnesses characterized by hallucinations, delusions, disorganized thought; they are often accompanied by cognitive dysfunction, social skills deficits, and low volition. This article reviews the extant literature on the efficacy of using yoga as an adjunct therapy to supplement standard pharmacotherapy and psychotherapy in the treatment and management of SSD. The 16 studies reviewed indicate yoga may be an effective intervention for increasing global cognitive functioning, decreasing psychotic symptoms, and improving quality of lif

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Zhou, *Fuchun, Nan Wang, Hang Li, Zhifang Zhang, and Chuanyue Wang. "IMPAIRED RESTING-STATE ANTERIOR PREFRONTAL FUNCTIONAL CONNECTIVITY ASSOCIATED WITH PROSPECTIVE MEMORY DEFICITS IN SCHIZOPHRENIA." International Journal of Neuropsychopharmacology 28, Supplement_1 (2025): i224—i225. https://doi.org/10.1093/ijnp/pyae059.393.

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Abstract Background Prospective memory (PM) deficit is one of the most common cognitive impairments of patients with schizophrenia spectrum disorders (SSDs). PM deficits have been associated with social functioning impairment, poor adherence to drugs and adverse clinical outcome. Previous studies have atributed the PM deficits in schizophrenia to the failure of cue detection and intention retrieval. In healthy people, these cognitive processes reflect the ability of strategic monitoring, which heavily rely on the functional network of anterior prefrontal cortex (aPFC) and related brain regions

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Malliaris, P., and K. Bonotis. "Correlation between alterations in cognitive function and mean severity of psychotic symptoms in patients diagnosed with schizophrenia spectrum disorders and its clinical application." European Psychiatry 64, S1 (2021): S811. http://dx.doi.org/10.1192/j.eurpsy.2021.2143.

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IntroductionSchizophrenia spectrum disorders (SSD) are characterized by heterogeneity. Cognitive decline, due to recent research results, appears to be a core symptom of schizophrenia. Dimensional approach of SSDs allows the separate assessment of each psychotic symptom, as well as cognitive functioning. Thus, correlations among them and their alterations, between baseline and follow up examination, can be estimated.ObjectivesThe objective of this study is to correlate observed alterations in cognitive performance in patients diagnosed with schizophrenia spectrum disorders, compared with basel

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Fantozzi, Pamela, Claudia Del Grande, Stefano Berloffa, et al. "Neurodevelopmental Disorders, Schizophrenia Spectrum Disorders and Catatonia: The “Iron Triangle” Rediscovered in a Case Report." Children 10, no. 1 (2022): 77. http://dx.doi.org/10.3390/children10010077.

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Catatonia is a complex neuropsychiatric syndrome, occurring in the context of different psychiatric and neurodevelopmental disorders, in neurological and medical disorders, and after substance abuse or withdrawal. The relationship between Autism Spectrum Disorder (ASD), Schizophrenia Spectrum Disorders (SSDs) and catatonia has been previously discussed, with the three disorders interpreted as different manifestations of the same underlying brain disorder (the “Iron Triangle”). We discuss in this paper the diagnostic, clinical and therapeutic implications of this complex relationship in an adol

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Dobrodeeva, Vera S., Natalia A. Shnayder, Maxim A. Novitsky, et al. "Association of a Single-Nucleotide Variant rs11100494 of the NPY5R Gene with Antipsychotic-Induced Metabolic Disorders." Pharmaceutics 14, no. 2 (2022): 222. http://dx.doi.org/10.3390/pharmaceutics14020222.

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Background: The usage of antipsychotics (APs) is the most robust and scientifically based approach in the treatment of schizophrenia spectrum disorders (SSDs). The efficiency of APs is based on a range of target receptors of the central nervous system (CNS): serotoninergic, dopaminergic, adrenergic, histaminergic and cholinergic. Metabolic disorders are the most severe adverse drug reactions (ADRs) and lead to cardiovascular diseases with a high rate of mortality in patients with SSDs. Neuropeptide Y receptor Y5 (NPY5R) is known in the chain of interaction to target receptors for APs, agouti-r

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Forastiere, A., S. Cascini, E. Calandrini, N. Agabiti, M. Davoli, and A. Bargagli. "Prevalence of schizophrenia spectrum disorders among adults in the Lazio region, Italy: use of an algorithm based on health information systems." European Psychiatry 65, S1 (2022): S208—S209. http://dx.doi.org/10.1192/j.eurpsy.2022.545.

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Introduction Mental healthcare provision is undergoing substantial reconfiguration in many regions of the world. Such changes require a broad evidence-based approach incorporating epidemiological data and information of local needs. Objectives To estimate the prevalence of schizophrenia spectrum disorders (SSDs) in the Lazio region and its geographical distribution using the regional health information systems (HIS). Methods Cases of SSDs (15-64-year-old) were identified using an algorithm based on data from the hospital discharge registry [ICD IX CM: 295, 297, 298 (excl. 298.0)] and the ticke

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Moura, Bernardo Melo, Geeske van Rooijen, Frederike Schirmbeck, et al. "A Network of Psychopathological, Cognitive, and Motor Symptoms in Schizophrenia Spectrum Disorders." Schizophrenia Bulletin 47, no. 4 (2021): 915–26. http://dx.doi.org/10.1093/schbul/sbab002.

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Abstract Schizophrenia spectrum disorders (SSDs) are complex syndromes involving psychopathological, cognitive, and also motor symptoms as core features. A better understanding of how these symptoms mutually impact each other could translate into diagnostic, prognostic, and, eventually, treatment advancements. The present study aimed to: (1) estimate a network model of psychopathological, cognitive, and motor symptoms in SSD; (2) detect communities and explore the connectivity and relative importance of variables within the network; and (3) explore differences in subsample networks according t

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Martin, James C., Scott R. Clark, and K. Oliver Schubert. "Towards a Neurophenomenological Understanding of Self-Disorder in Schizophrenia Spectrum Disorders: A Systematic Review and Synthesis of Anatomical, Physiological, and Neurocognitive Findings." Brain Sciences 13, no. 6 (2023): 845. http://dx.doi.org/10.3390/brainsci13060845.

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The concept of anomalous self-experience, also termed Self-Disorder, has attracted both clinical and research interest, as empirical studies suggest such experiences specifically aggregate in and are a core feature of schizophrenia spectrum disorders. A comprehensive neurophenomenological understanding of Self-Disorder may improve diagnostic and therapeutic practice. This systematic review aims to evaluate anatomical, physiological, and neurocognitive correlates of Self-Disorder (SD), considered a core feature of Schizophrenia Spectrum Disorders (SSDs), towards developing a neurophenomenologic

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Bondrescu, Mariana, Liana Dehelean, Simona Sorina Farcas, et al. "Cognitive Impairments Related to COMT and Neuregulin 1 Phenotypes as Transdiagnostic Markers in Schizophrenia Spectrum Patients." Journal of Clinical Medicine 13, no. 21 (2024): 6405. http://dx.doi.org/10.3390/jcm13216405.

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Background: Research on the interaction between antipsychotic treatment and cognitive dysfunction in schizophrenia spectrum disorders (SSDs) is extensive, yet the role of genetic polymorphisms in catechol-O-methyltransferase (COMT) and neuregulin 1 (NRG1) remains underexplored. Methods: This study evaluates the impact of COMT (rs4680) and NRG1 (rs3924999 and rs35753505) polymorphisms on cognitive functions in SSD patients. A cross-sectional study was conducted with fifty-four patients, assessed using the Positive and Negative Syndrome Scale (PANSS) and the CNS Vital Signs battery. Results: Sig

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Beebe, Lora Humphrey, Kathlene D. Smith, Marian W. Roman, et al. "A Pilot Study Describing Physical Activity in Persons with Schizophrenia Spectrum Disorders (SSDS) after an Exercise Program." Issues in Mental Health Nursing 34, no. 4 (2013): 214–19. http://dx.doi.org/10.3109/01612840.2012.746411.

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Beebe, Lora Humphrey, Kathleen Smith, and Chad Phillips. "Descriptions and Correlates of Medication Adherence, Attitudes, and Self-Efficacy in Outpatients With Schizophrenia Spectrum Disorders (SSDs)." Archives of Psychiatric Nursing 30, no. 3 (2016): 400–405. http://dx.doi.org/10.1016/j.apnu.2016.01.010.

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Filipcic, I., I. Simunovic Filipcic, E. Ivezic, et al. "Chronic physical illnesses in patients with schizophrenia spectrum disorders are independently associated with higher rates of psychiatric rehospitalization; a cross-sectional study in Croatia." European Psychiatry 43 (June 2017): 73–80. http://dx.doi.org/10.1016/j.eurpsy.2017.02.484.

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AbstractBackground:Increased physical morbidity in patients with schizophrenia spectrum disorders (SSDs) is well documented. However, much less is known about the association between somatic comorbidities and psychosis treatment outcomes.Subjects and methods:This cross-sectional study, nested within the larger frame of a prospective cohort study, was done in 2016 at Psychiatric Hospital Sveti Ivan, Zagreb, Croatia. Data were collected on a consecutive sample of 301 patients diagnosed with schizophrenia spectrum disorders who achieved a stable therapeutic dosage. Key outcome was the number of p

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Browne, Julia, Philip D. Harvey, Robert W. Buchanan, et al. "A Longitudinal Examination of Real-World Sedentary Behavior in Adults with Schizophrenia-Spectrum Disorders in a Clinical Trial of Combined Oxytocin and Cognitive Behavioral Social Skills Training." Behavioral Sciences 12, no. 3 (2022): 60. http://dx.doi.org/10.3390/bs12030060.

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Sedentary behavior contributes to a shortened life expectancy in individuals with schizophrenia-spectrum disorders (SSDs), highlighting the need for effective interventions to improve health. This study examined whether reduced ecological momentary assessment (EMA) measures of sedentary activities were observed in individuals with SSDs who participated in a 24-week randomized trial of cognitive behavioral social skills training (CBSST) and either intranasal oxytocin or placebo (NCT01752712). Participants (n = 57) were prompted with EMA surveys seven times per day for seven days during the base

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Murillo-Garcia, N., S. Papiol, S. Barrio-Martínez, et al. "The use of Polygenic Scores in a family design of First Episode Psychosis." European Psychiatry 66, S1 (2023): S631. http://dx.doi.org/10.1192/j.eurpsy.2023.1312.

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IntroductionA wide variety of traits is heritable and has genetic loading, including schizophrenia spectrum disorders (SSDs) and its associated neurocognitive features. The genetic architecture of SSDs is polygenic, with the contribution of thousands of single nucleotide polymorphisms of small effect with an estimated SNP-heritability of 24%. The same occurs with neurocognitive phenotypes such as intelligence or educational attainment. Therefore, the method of polygenic risk scores (PRS) is useful in estimating the genetic burden of such traits. Moreover, the use of PRS in a sample of genetica

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Jeon, Eun-Jin, Shi-Hyun Kang, Yan-Hong Piao, et al. "Development of the Korea-Polyenvironmental Risk Score for Psychosis." Psychiatry Investigation 19, no. 3 (2022): 197–206. http://dx.doi.org/10.30773/pi.2021.0328.

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Objective Comprehensive understanding of polyenvironmental risk factors for the development of psychosis is important. Based on a review of related evidence, we developed the Korea Polyenvironmental Risk Score (K-PERS) for psychosis. We investigated whether the K-PERS can differentiate patients with schizophrenia spectrum disorders (SSDs) from healthy controls (HCs).Methods We reviewed existing tools for measuring polyenvironmental risk factors for psychosis, including the Maudsley Environmental Risk Score (ERS), polyenviromic risk score (PERS), and Psychosis Polyrisk Score (PPS). Using odds r

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Shen, Jie, Guangfan Shen, Woo-Sung Kim, et al. "Neuronal Signatures of Negative and Positive Schemas towards the Self and Others in Patients with Early Stage Schizophrenia." Psychiatry Investigation 18, no. 4 (2021): 284–94. http://dx.doi.org/10.30773/pi.2020.0335.

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Objective The present study investigated the functional neuroanatomy underlying negative and positive schemas towards the self and others in patients with early stage schizophrenia spectrum disorders (SSDs) using a task-based fMRI procedure.Methods This study included 50 patients with SSDs and 52 controls. The schema-evoking task consisted of four active conditions and neutral condition. Differences in brain activation were compared between the two groups. Correlation analysis was performed between task-related activation and psychopathology.Results The SSD patients exhibited higher activity o

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Bondrescu, Mariana, Liana Dehelean, Simona Sorina Farcas, et al. "COMT and Neuregulin 1 Markers for Personalized Treatment of Schizophrenia Spectrum Disorders Treated with Risperidone Monotherapy." Biomolecules 14, no. 7 (2024): 777. http://dx.doi.org/10.3390/biom14070777.

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Pharmacogenetic markers are current targets for the personalized treatment of psychosis. Limited data exist on COMT and NRG1 polymorphisms in relation to risperidone treatment. This study focuses on the impact of COMT rs4680 and NRG1 (rs35753505, rs3924999) polymorphisms on risperidone treatment in schizophrenia spectrum disorders (SSDs). This study included 103 subjects with SSD treated with risperidone monotherapy. COMT rs4680, NRG1 rs35753505, and rs3924999 were analyzed by RT-PCR. Participants were evaluated via the Positive and Negative Syndrome Scale (PANSS) after six weeks. Socio-demogr

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Beebe, Lora Humphrey, Kathlene Smith, and Chad Phillips. "Effect of a Telephone Intervention Upon Self-Reported Medication Adherence and Self-Efficacy in Outpatients With Schizophrenia Spectrum Disorders (SSDs)." Issues in Mental Health Nursing 37, no. 10 (2016): 708–14. http://dx.doi.org/10.1080/01612840.2016.1214855.

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Nasyrova, R. F., N. A. Shnayder, I. R. Boiko, et al. "Single-Nucleotide Variant rs167771 of the DRD3 Gene Does Not Increase the Risk of Developing Antipsychotic-Induced Parkinsonism in Schizophrenic Patients." Personalized Psychiatry and Neurology 5, no. 1 (2025): 32–44. https://doi.org/10.52667/2712-9179-2025-5-1-32-44.

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Antipsychotic-induced parkinsonism (AIP) is a form of secondary parkinsonism that most often develops with blockade of dopaminergic receptors type D2. However, AIP can oc-cur not only while taking first-generation APs, but also new ones that have a wider receptor pro-file. There is a connection between the DRD3 gene and the regulation of motor activity in associa-tion genetic studies of AIP; Aim: to study the role of single-nucleotide variant rs167771 of the DRD3 gene, encoding dopaminergic receptors D3 type, with the risk of AIP in Caucasian patients with schizophrenia spectrum disorders (SSD

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Beebe, Lora H., Kathlene Smith, Chad Phillips, Dawn Velligan, and Abbas Tavakoli. "The Long-Term Effects of Cellular Telephone-Delivered Telephone Intervention Problem Solving (TIPS) for Schizophrenia Spectrum Disorders (SSDs): Rationale and Design." Clinical Schizophrenia & Related Psychoses 11, no. 3 (2017): 164–71. http://dx.doi.org/10.3371/csrp.besm.103114.

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Hofmann, Lena A., Steffen Lau, and Johannes Kirchebner. "Advantages of Machine Learning in Forensic Psychiatric Research—Uncovering the Complexities of Aggressive Behavior in Schizophrenia." Applied Sciences 12, no. 2 (2022): 819. http://dx.doi.org/10.3390/app12020819.

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Linear statistical methods may not be suited to the understanding of psychiatric phenomena such as aggression due to their complexity and multifactorial origins. Here, the application of machine learning (ML) algorithms offers the possibility of analyzing a large number of influencing factors and their interactions. This study aimed to explore inpatient aggression in offender patients with schizophrenia spectrum disorders (SSDs) using a suitable ML model on a dataset of 370 patients. With a balanced accuracy of 77.6% and an AUC of 0.87, support vector machines (SVM) outperformed all the other

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De Juan Viladegut, O., M. Llobet Farré, H. Andreu Gracia, et al. "Psychotic disorders in young patients with Prader-Willi syndrome: A case report and literature review." European Psychiatry 66, S1 (2023): S395. http://dx.doi.org/10.1192/j.eurpsy.2023.853.

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IntroductionPrader-Willi syndrome (PWS) is a genetic disorder with an estimated prevalence of 1:25,000. PWS results from defective gene expression on the paternal copy of chromosome 15. In 70% of the cases it is a deletion that means that part of the paternal chromosome 15 is missing. Maternal uniparental disomy (mUPD) is present in 25% of cases. Typical clinical features of PWS are dysmorphism, hypotonia, hyperphagia, hypogonadism and developmental delay. In addition, the syndrome is accompanied by various psychiatric symptoms that are often insufficiently known within the psychiatric field.

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Adler, Daniel A., Dror Ben-Zeev, Vincent W.-S. Tseng, et al. "Predicting Early Warning Signs of Psychotic Relapse From Passive Sensing Data: An Approach Using Encoder-Decoder Neural Networks." JMIR mHealth and uHealth 8, no. 8 (2020): e19962. http://dx.doi.org/10.2196/19962.

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Background Schizophrenia spectrum disorders (SSDs) are chronic conditions, but the severity of symptomatic experiences and functional impairments vacillate over the course of illness. Developing unobtrusive remote monitoring systems to detect early warning signs of impending symptomatic relapses would allow clinicians to intervene before the patient’s condition worsens. Objective In this study, we aim to create the first models, exclusively using passive sensing data from a smartphone, to predict behavioral anomalies that could indicate early warning signs of a psychotic relapse. Methods Data

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Escobedo-Aedo, Paula Jhoana, Ana Forjan-González, Adela Sánchez-Escribano Martínez, et al. "Investigating the Role of Insight, Decision-Making and Mentalizing in Functional Outcome in Schizophrenia: A Cross-Sectional Study." Behavioral Sciences 12, no. 2 (2022): 28. http://dx.doi.org/10.3390/bs12020028.

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Background: Recovery has become a priority in schizophrenia spectrum disorders (SSDs). This study aimed to investigate predictors of objective—general functioning and disability—and subjective—quality of life (QoL)—measures of functional outcomes in SSD. Methods: Sample: n = 77 SSD outpatients (age 18–64, IQ > 70) participating in a randomised controlled trial. Baseline data were used to build three multivariable linear regression models on: (i) general functioning—General Assessment of Functioning (GAF); (ii) disability—the World Health Organization Disability Assessment Schedule (WHODAS-2

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Aronica, Rosario, Edoardo Giuseppe Ostinelli, Charlotte Austin, et al. "Digital sleep phenotype and wrist actigraphy in individuals at clinical high risk for psychosis and people with schizophrenia spectrum disorders: a systematic review and meta-analysis." BMJ Mental Health 28, no. 1 (2025): e301337. https://doi.org/10.1136/bmjment-2024-301337.

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AimTo identify sleep abnormalities in individuals at clinical high risk for psychosis (CHR-P) or with schizophrenia spectrum disorders (SSDs) compared with healthy controls (HCs) using wrist actigraphy, and to assess potential differences in the direction of effect with self-reported assessments of sleep.MethodsWe conducted a systematic review of observational studies, with the search last updated on 29 April 2024. Primary outcome was total sleep time (TST), with secondary outcomes including time in bed (TIB), sleep latency, sleep efficiency, wake after sleep onset, nighttime awakenings and se

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Andrade, Pedro, Nuno Sanfins, and Jacinto Azevedo. "Mend the Gap: Online User-Led Adjuvant Treatment for Psychosis: A Systematic Review on Recent Findings." International Journal of Environmental Research and Public Health 22, no. 7 (2025): 1024. https://doi.org/10.3390/ijerph22071024.

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Background/Objectives: Schizophrenia Spectrum Disorders (SSDs) carry a debilitating burden of disease which, even after pharmacological and psychological treatment are optimized, remains difficult to fully target. New online-delivered and user-led interventions may provide an appropriate, cost-effective answer to this problem. This study aims to retrieve the currently gathered findings on the efficacy of these interventions across several outcomes, such as symptom severity, social cognition, functioning and others. Methods: A systematic review of the current available literature was conducted.

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Laine, Anna, Minna Anttila, Heli Hirvonen, and Maritta Välimäki. "Feasibility of a Web-Based Psychoeducation Course and Experiences of Caregivers Living With a Person With Schizophrenia Spectrum Disorder: Mixed Methods Study." Journal of Medical Internet Research 23, no. 4 (2021): e25480. http://dx.doi.org/10.2196/25480.

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Background Schizophrenia is a severe mental illness that burdens both patients and caregivers. Objective The aim of this study is to examine the feasibility of a web-based psychoeducation course targeted at caregivers of persons with schizophrenia spectrum disorders (SSDs) and to describe their experiences of living with a person with SSD based on the material caregivers produced during the web-based course. Methods A convergent, parallel, mixed methods study design was used. First, caregivers’ engagement in the course was evaluated quantitatively. Second, the overview of the course feedback w

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Jung, Yoon-Sun, Young-Eun Kim, Dun-Sol Go, and Seok-Jun Yoon. "The prevalence, incidence, and admission rate of diagnosed schizophrenia spectrum disorders in Korea, 2008–2017: A nationwide population-based study using claims big data analysis." PLOS ONE 16, no. 8 (2021): e0256221. http://dx.doi.org/10.1371/journal.pone.0256221.

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This study estimated the prevalence and incidence rate of schizophrenia, schizotypal, and delusional disorders (SSDD) in Korea from 2008 to 2017 and analyzed the hospital admission rate, re-admission rate, and hospitalization period. It used the Korean nationwide National Health Insurance Service claims database. SSDD patients who had at least one visit to Korea’s primary, secondary, or tertiary referral hospitals with a diagnosis of SSDD, according to the International Classification of Diseases, 10th Revision (ICD-10), were identified as SSDD cases if coded as F20-F29. Data were analyzed usi

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Smith, *Emily Chen Chen, Kristoffer Panganiban, Kateryna Maksyutynska, et al. "DYSGLYCEMIA ASSOCIATED WITH ANTIPSYCHOTIC USE: A SYSTEMATIC REVIEW." International Journal of Neuropsychopharmacology 28, Supplement_1 (2025): i27. https://doi.org/10.1093/ijnp/pyae059.048.

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Abstract Background Antipsychotics (APs) are the cornerstone of treatment for schizophrenia spectrum disorders (SSDs) and are approved for treatment of affective disorders including bipolar disorder (BD). However, AP use is associated with severe metabolic consequences including weight gain, dyslipidemia, and dysglycemia. Although studies indicate that glucose dysfunction can occur independently of weight gain, AP-induced glycemic changes are most often considered to be a consequence of AP-induced weight gain. Aim & Objectives The aims of this review are to 1) specifically clarify the effe

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Nasyrova, Regina F., Natalia A. Shnayder, Sofia M. Osipova, et al. "Genetic Predictors of Antipsychotic Efflux Impairment via Blood-Brain Barrier: Role of Transport Proteins." Genes 14, no. 5 (2023): 1085. http://dx.doi.org/10.3390/genes14051085.

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Antipsychotic (AP)—induced adverse drug reactions (ADRs) are a current problem of biological and clinical psychiatry. Despite the development of new generations of APs, the problem of AP-induced ADRs has not been solved and continues to be actively studied. One of the important mechanisms for the development of AP-induced ADRs is a genetically-determined impairment of AP efflux across the blood-brain barrier (BBB). We present a narrative review of publications in databases (PubMed, Springer, Scopus, Web of Science E-Library) and online resources: The Human Protein Atlas; GeneCards: The Human G

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Mandarelli, G., F. Carabellese, G. Parmigiani, et al. "Treatment decision-making capacity in non-consensual psychiatric treatment: a multicentre study." Epidemiology and Psychiatric Sciences 27, no. 5 (2017): 492–99. http://dx.doi.org/10.1017/s2045796017000063.

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Aims.To evaluate treatment decision-making capacity (DMC) to consent to psychiatric treatment in involuntarily committed patients and to further investigate possible associations with clinical and socio-demographic characteristics of patients.Methods.131 involuntarily hospitalised patients were recruited in three university hospitals. Mental capacity to consent to treatment was measured with the MacArthur Competence Assessment Tool for Treatment (MacCAT-T); psychiatric symptoms severity (Brief Psychiatric Rating Scale, BPRS-E) and cognitive functioning (Mini Mental State Examination, MMSE) wer

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Widiger, T. A., A. J. Frances, and M. Sweeney. "Schizophrenia spectrum disorders." Current Opinion in Psychiatry 1, no. 1 (1988): 13–18. http://dx.doi.org/10.1097/00001504-198801000-00004.

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Tsapakis, E. M., D. Paitaridou, M. Koummati, et al. "Manic symptoms in schizophrenia spectrum disorders." Brain Medicine, February 11, 2025, 1–7. https://doi.org/10.61373/bm025r.0005.

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This study investigated the presence of manic symptoms in stable patients diagnosed with schizophrenia spectrum disorders (SSDs) aiming to identify their association with clinical symptoms. A total of 75 out-patients, 41.3% female [47.81 (±10.521) year-old] were assessed using the Young Mania Rating Scale (YMRS), Positive and Negative Syndrome Scale (PANSS), Generalized Anxiety Disorder-7 scale (GAD-7), and Risk Assessment of Suicidality Scale (RASS). Participants were divided into two groups based on YMRS scores: Group 1, without or with minimal symptoms of mania (YMRS ≤ 10) and Group 2, with

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