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Journal articles on the topic 'Schwank'

Author: Grafiati

Published: 4 June 2021

Last updated: 27 July 2025

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1

BALSAMO, MARIA, JEAN-LOUP D’HONDT, LARA PIERBONI, and PAOLO GRILLI. "Taxonomic and nomenclatural notes on freshwater Gastrotricha." Zootaxa 2158, no. 1 (2009): 1–19. http://dx.doi.org/10.11646/zootaxa.2158.1.1.

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Some taxonomic and nomenclatural remarks concerning freshwater species of Gastrotricha Chaetonotida are presented. In the family Chaetonotidae, the subgenus Chaetonotus (Hystricochaetonotus) is synonimized with the subgenus C. (Chaetonotus sensu stricto). The genus Lepidochaetus is moved to a subgeneric rank into the genus Chaetonotus, and the subgenus Nudichaetonotus Schwank, 1990 is synonymized with C. (Lepidochaetus). Chaetonotus (Lepidochaetus) brasilianus is proposed as a replacement name for Chaetonotus brasilense Kisielewski, 1991, which has become a secondary junior homonym of Chaetono

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2

Yurkina, Yana. "From the History of the Literary Activity of Andreas Saks, a Russian and German Writer: The Preparation of His Schwanks for Publication in Russian (1960–1970)." Izvestia of Smolensk State University, no. 3 (55) (January 26, 2022): 28–40. http://dx.doi.org/10.35785/2072-9464-2021-55-3-28-40.

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Andreas Saks (1903–1983), a Russian (Soviet) ethnic German playwright, prose writer and poet has been one of the most well-known authors of prosaic schwanks in Russian German literature. The article is the first effort to describe how he prepared his schwanks for publication in Russian. In the 1960–1970s, he lived and worked first in Astrakhan, and then in Tiraspol, he wrote and published his schwanks in German. His first publications appeared as a rule on the pages of Soviet German newspapers. Thus, in the conditions of Soviet post-war and post-Stalin reality, he sought, firstly, to ret

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3

Menke - Schnellbächer, Kirsten. "GELÄCHTER UND VERLACHEN." Daphnis 40, no. 3-4 (2011): 641–64. http://dx.doi.org/10.1163/18796583-90000849.

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Der Beitrag stellt die Möglichkeiten einer an der kognitiven Narratologie ausgerichteten Analyse der Figurendarstellung und sich daran anschließende Überlegungen zur Rezipientenwahrnehmung vor. Als Beispielfiguren dienen Geistliche (allesamt Vertreter des weltlichen Klerus) aus sechs Texten, die sich unter dem Oberbegriff ‘Schwank’ subsumieren lassen. Die Kleriker im Schwank werden in der Regel als stereotype Figuren wahrgenommen, die klischeehaft dem Topos des ‘liebestollen Pfaffen’ entsprechen — auch die Forschung teilt diese Ansicht und widmet ihnen daher kaum Aufmerksamkeit. Allerdings öff

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4

Mukataieva, Yaroslava. "The synergetic model of the German schwank." Nova fìlologìâ, no. 77 (2019): 35–39. http://dx.doi.org/10.26661/2414-1135/2019-77-06.

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5

Houben, Albrecht M., Peter Schwank, Willem Proesmans, Wim Bert, and Tom J. Artois. "Notes on some enigmatic taxa of limnoterrestrial rhabdocoels, with the description of two new species." Zootaxa 4040, no. 1 (2015): 83–92. https://doi.org/10.11646/zootaxa.4040.1.7.

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Houben, Albrecht M., Schwank, Peter, Proesmans, Willem, Bert, Wim, Artois, Tom J. (2015): Notes on some enigmatic taxa of limnoterrestrial rhabdocoels, with the description of two new species. Zootaxa 4040 (1): 83-92, DOI: 10.11646/zootaxa.4040.1.7

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6

Schwank, Peter, and Tobias Kånneby. "Contribution to the freshwater gastrotrich fauna of wetland areas of southwestern Ontario (Canada) with redescriptions of seven species and a check-list for North America." Zootaxa 3811, no. 4 (2014): 463–90. https://doi.org/10.11646/zootaxa.3811.4.3.

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Schwank, Peter, Kånneby, Tobias (2014): Contribution to the freshwater gastrotrich fauna of wetland areas of southwestern Ontario (Canada) with redescriptions of seven species and a check-list for North America. Zootaxa 3811 (4): 463-490, DOI: 10.11646/zootaxa.3811.4.3

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7

Aksöz, Munise. "“Schwank” Edebiyat Kavramı için Türkçe Öneri: Neşeli Öykü." Türkiyat Mecmuası / Journal of Turkology 34, no. 1 (2024): 333–51. http://dx.doi.org/10.26650/iuturkiyat.1424935.

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8

YILDIRIM, Munise. "Produktıonsorıentıerter Lıteraturunterrıcht: Eınübung Der Lıteraturgattung Schwank Durch Waldmanns P." Journal of Turkish Studies 8, Volume 8 Issue 8 (2013): 1503. http://dx.doi.org/10.7827/turkishstudies.5053.

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9

Tuczay, Christa. "Das Motiv der drei Wünsche in Schwank, Legendenmärchen und Witz." Fabula 40, no. 1-2 (1999): 85–109. http://dx.doi.org/10.1515/fabl.1999.40.1-2.85.

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10

Ivanyuk, B. P. "Narrative Poetic Genres: Story, Lay, Gavenda, Novella, Fabliau, Schwank (Dictionary Format)." Philologos 46, no. 3 (2020): 44–49. http://dx.doi.org/10.24888/2079-2638-2020-46-3-44-49.

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11

Drukarov, Mikhail Evgen'evich. "Schwank Figurative Means as a Key to Understanding the Russian Germans’ Worldview." Filologičeskie nauki. Voprosy teorii i praktiki, no. 5 (May 2020): 193–99. http://dx.doi.org/10.30853/filnauki.2020.5.38.

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12

Poddubnaya, Natalya N. "Specificity of modality representation in the comic text of the Russian Germans' schwank." Vestnik Tomskogo gosudarstvennogo universiteta. Filologiya, no. 2(34) (April 1, 2015): 45–54. http://dx.doi.org/10.17223/19986645/34/5.

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13

KIENEKE, ALEXANDER, and OLE RIEMANN. "First record of rare dasydytid gastrotrich Setopus tongiorgii (Balsamo, 1982) from central Europe with some biological data." Zootaxa 1680, no. 1 (2008): 59. http://dx.doi.org/10.11646/zootaxa.1680.1.4.

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Members of the freshwater family Dasydytidae belong to the rarest gastrotrichs although some species like Stylochaeta scirtetica may develop high population densities (Schwank 1990). The taxon Dasydytidae is characterised by several apomorphic features correlated to a semi-planktonic lifestyle. Species of Dasydytidae have, for example, completely lost their caudal adhesive tubes, they possess a system of ciliary bands in the head region with which they swim like ciliated larvae of annelids, and most species have motile spines to perform saltatory movements in the water column. So far, our know

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14

Smolej, Tone, and Tanja Žigon. "Kotzebues komische dramatische Formen auf der Ständischen Bühne in Laibach von 1830 bis 1840." Acta Neophilologica 56, no. 1-2 (2023): 303–23. http://dx.doi.org/10.4312/an.56.1-2.303-323.

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Die dramatischen Werke des deutschen Dramatikers, Schriftstellers und Librettisten August von Kotzebue (1761–1819) gehörten in der ersten Hälfte des 19. Jahrhunderts nicht nur zum festen Repertoire des Ständischen Theaters in Laibach (Ljubljana), sondern Kotzebue gehörte in den 1830er-Jahren, wie aus den Spielplänen ersichtlich, zu den meistgespielten Dramatikern auf der Laibacher Bühne. Es wurden sowohl seine ernsteren Schauspiele als auch Werke komischen Inhalts aufgeführt. Vor allem bei den Letzteren ist eine rege Vielfalt an komischen dramatischen Formen (z. B. Lustspiel, Schwank, Posse) z

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15

Kuhn, Christian. "Vom Predigtexempel zum Konfliktmedium. Geschichtswissenschaftliche Perspektiven auf den Schwank an der Wende zur Neuzeit." Mitteilungen des Deutschen Germanistenverbandes 62, no. 1 (2015): 80–93. http://dx.doi.org/10.14220/mdge.2015.62.1.80.

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16

Brady, Philip, and Elfriede Moser-Rath. "'Lustige Gesellschaft': Schwank und Witz des 17. und 18. Jahrhunderts in kultur- und sozialgeschichtlichem Kontext." Modern Language Review 82, no. 2 (1987): 512. http://dx.doi.org/10.2307/3728508.

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17

Popova, Olga V. "THE MOTIF OF VIOLATING THE BAN IN MEDIEVAL POEMS ABOUT THE SWAN KNIGHT." RSUH/RGGU Bulletin. "Literary Theory. Linguistics. Cultural Studies" Series, no. 6 (2022): 258–70. http://dx.doi.org/10.28995/2686-7249-2022-6-258-270.

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The article considers the transformation of the motif of violating the ban in the medieval versions of the “plot of the Swan Knight” in the French and German traditions. While in the French sources the heroine’s violation implies the theme of the struggle between God and the devil, in the Germanlanguage versions the individual motivations of the characters’ behavior are emphasised. The article suggests a possible borrowing by the creators of German poems of the plot-forming motif of a folklore anecdote or urban schwank about Clever Elsa – the motif of the heroine’s thoughts about the future of

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18

Fluhrer, Sandra. "„A a a“. Zur Komik bäuerlicher Rede in Schwank und Anekdote (Ovid, Wickram, Sachs und Hebel)." Figurationen 26, no. 1 (2025): 11–26. https://doi.org/10.7788/figu-2025-260104.

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19

Dünnhaupt, Gerhard. "Elfriede Moser-Rath,„Lustige Gesellschaft“. Schwank und Witz des 17. und 18. Jahrhunderts in kultur- und sozialgeschichtlichem Kontext." Arbitrium 2, no. 1 (1986): 169–70. http://dx.doi.org/10.1515/arbi.1986.2.1.169.

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20

Uther, Hans-Jörg. "Glück im Unglück. Hans Christian Andersens Schwank„Was Vater tut, ist stets das Richtige“im Spiegel literarischer und mündlicher Überlieferungen." Fabula 46, no. 1-2 (2005): 116–25. http://dx.doi.org/10.1515/fabl.2005.46.1-2.116.

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21

Uther, Hans-Jörg. "Glück im Unglück. Hans Christian Andersens Schwank „Was Vater tut, ist stets das Richtige“ im Spiegel literarischer und mündlicher Überlieferungen." Fabula 46, no. 1part2 (2005): 116–25. http://dx.doi.org/10.1515/fabl.2005.46.1part2.116.

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22

Schnyder, André. "Mareike von Müller: Schwarze Komik. Narrative Sinnirritationen zwischen Märe und Schwank, Heidelberg: Winter 2017, 381 S. (Studien zur historischen Poetik 24)." Beiträge zur Geschichte der deutschen Sprache und Literatur 140, no. 3 (2018): 431–39. http://dx.doi.org/10.1515/bgsl-2018-0033.

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23

Поддубная, Наталья Николаевна. "Language Game as a Way of Actualization of the Comic Feature in a Short Humorous Story (Based on a Schwank of Russian Germans)." Philology & Human, no. 3 (2020): 19–30. http://dx.doi.org/10.14258/filichel(2020)3-02.

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24

Reich, Philip. "Mareike von Müller, Schwarze Komik. Narrative Sinnirritationen zwischen Märe und Schwank. (Studien zur historischen Poetik 24) Winter, Heidelberg 2017. 381 S., € 58,–." Arbitrium 39, no. 3 (2021): 299–302. http://dx.doi.org/10.1515/arb-2021-0064.

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25

Os'mukhina, Ol'ga Yur'evna, and Mariya Andreevna Bogatova. "FOOL’S LITERATURE TRADITION IN THE NORTHERN RENAISSANCE LITERATURE (BY THE MATERIAL OF THE GERMAN SCHWANK, SCHILDBÜRGER CHAPBOOK AND “THE PRAISE OF FOLLY” BY ERASMUS OF ROTTERDAM)." Philological Sciences. Issues of Theory and Practice, no. 11 (November 2019): 136–40. http://dx.doi.org/10.30853/filnauki.2019.11.30.

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26

Yako, Hideji, Naoko Niimi, Shizuka Takaku, Junji Yamauchi, and Kazunori Sango. "Epalrestat Alleviates Reactive Oxygen Species and Endoplasmic Reticulum Stress by Maintaining Glycosylation in IMS32 Schwann Cells Under Exposure to Galactosemic Conditions." International Journal of Molecular Sciences 26, no. 4 (2025): 1529. https://doi.org/10.3390/ijms26041529.

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Aldose reductase (AR), a rate-limiting enzyme in the polyol pathway, mediates the conversion of several substrates, including glucose and galactose. In rodents, galactosemia induced by galactose feeding has been shown to develop peripheral nerve lesions resembling diabetic peripheral neuropathy. However, the mechanisms by which AR-mediated responses elicited Schwan cell lesions under galactosemic conditions remain unresolved. To investigate this, we examined the mechanism of high-galactose-induced damage mediated by AR using AR inhibitors such as ranirestat and epalrestat. The exposure of IMS3

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27

Bohdanets, Svitlana. "Gastronomic Humor in Medieval European Literature: Topoi and Historiography." Text and Image: Essential Problems in Art History, no. 2 (2019): 34–43. http://dx.doi.org/10.17721/2519-4801.2019.2.02.

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The article looks at topoi in gastronomic images of European medieval humoristic texts and seeks to examine the connection between food and comic discourses. The author shall also highlight how these images were evaluated and interpreted by scholars of a different methodological background. The attention is paid to motives in gastronomic humour and comic plots related to food, which were widely spread in Western culture. Gastronomic humour is displayed through examples that are to be found in such medieval literary genres as farce, fabliau, Schwank etc. The study aims to propose a common food

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Bayard, Florence. "Mareike von Müller , Schwarze Komik. Narrative Sinnirritationen zwischen Märe und Schwank , Heidelberg, Universitätsverlag Winter, 2017 ; 1 vol., 381 p. ( Studien zur historischen Poetik , 24). ISBN : 978-3-8253-6746-6. Prix : € 58,00." Le Moyen Age Tome CXXV, no. 1 (2020): XXXI. http://dx.doi.org/10.3917/rma.251.0213ze.

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29

Harms, Udo. "Annabergit-Mischkristalle aus dem Steinbruch Rohdenhaus bei Wülfrath (Niederbergisches Land) - Mineralchemie und Bildungsbedingungen." Decheniana : Verhandlungen des Naturhistorischen Vereins der Rheinlande und Westfalens 163 (January 1, 2010): 169–77. http://dx.doi.org/10.21248/decheniana.v163.4641.

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Annabergit-Mischkristalle aus dem Steinbruch Rohdenhaus bei Wülfrath wurden quantitativ mit der Elektronenstrahlmikrosonde analysiert. Die Kristalle enthalten im wesentlichen NiO (4,61-17,83 Gew.-%), CoO (2,75-12,63 Gew.-%) und ZnO (6,00-28,64 Gew.-%). Die FeO und MgO-Gehalte bleiben jeweils unter 1,5 Gew.-%. ‎As2O5 schwankt zwischen 37,23 und 40,68 Gew.-%. Die Kristalle zeigen eine fast vollständige Mischkristallbildung in Richung Köttigit-Endglied. (a Ni2+/a Co2+) Verhältnisse von 18,05 bis 23,8 und (a Ni2+ /a Zn2+) Verhältnisse von 1,76 bis 4,66 sind in den wässrigen Verwitterungslösungen,

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Sathyanarayanan, Ramanujam, Raghu Kumaravelu, and Nithin J. Jude. "An Uncommon and Rare Soft Tissue Tumor of the Cheek (Schwannoma): A Case Report." Journal of Scientific Dentistry 10, no. 2 (2020): 38–40. http://dx.doi.org/10.5005/jp-journals-10083-0936.

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ABSTRACT Schwannoma is usually an uncommon, benign, encapsulated, very slow-growing, usually solitary tumor that originates from Schwann cells of the nerve sheath derived from the neuroectoderm. Only 1% of schwannomas was intraoral of which the most common site is always the tongue after which the palate, floor of the mouth, buccal mucosa, lips, and jaws can be affected. Schwannoma is an uncommon benign tumor that originates from the Schwan cell of the peripheral nerves. It is difficult to diagnose clinically. In our case, the patient reported a solitary swelling present on the left cheek. The

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Abd Razak, Nurul Husna, Jalilah Idris, Nur Hidayah Hassan, Fazlin Zaini, Noorzaid Muhamad, and Muhammad Fauzi Daud. "Schwann Cells Reprogram Into Repair Phenotype Instead of Dedifferentiating to Immature Phenotype in in Vitro Culture." ICMST 19, s9 (2023): 107–12. http://dx.doi.org/10.47836/mjmhs.19.s9.16.

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Introduction: In vitro cultured Schwann cell has been suggested to adopt a phenotype of undifferentiated immature Schwann cells found in vivo during development. However, recent studies indicate that Schwann cells undergo cellular reprogramming into the phenotype of repair Schwann cells instead of reverting to an immature phenotype after peripheral nerve injury. The study hypothesized that in in vitro culture, Schwann cells assume the repair phenotype instead of de-differentiating to immature Schwann cells, similar to in vivo nerve injury response. Therefore, this study aimed to characterize t

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Einheber, S., M. J. Hannocks, C. N. Metz, D. B. Rifkin, and J. L. Salzer. "Transforming growth factor-beta 1 regulates axon/Schwann cell interactions." Journal of Cell Biology 129, no. 2 (1995): 443–58. http://dx.doi.org/10.1083/jcb.129.2.443.

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We have investigated the potential regulatory role of TGF-beta in the interactions of neurons and Schwann cells using an in vitro myelinating system. Purified populations of neurons and Schwann cells, grown alone or in coculture, secrete readily detectable levels of the three mammalian isoforms of TGF-beta; in each case, virtually all of the TGF-beta activity detected is latent. Expression of TGF-beta 1, a major isoform produced by Schwann cells, is specifically and significantly downregulated as a result of axon/Schwann cell interactions. Treatment of Schwann cells or Schwann cell/neuron cocu

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Mason, P. W., J. W. Bigbee, and G. H. DeVries. "Cerebellar granule cells contain a membrane mitogen for cultured Schwann cells." Journal of Cell Biology 108, no. 2 (1989): 607–11. http://dx.doi.org/10.1083/jcb.108.2.607.

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Proliferation of Schwann cells is one of the first events that occurs after contact with a growing axon. To further define the distribution and properties of this axonal mitogen, we have (a) cocultured cerebellar granule cells, which lack glial ensheathment in vivo with Schwann cells; and (b) exposed Schwann cell cultures to isolated granule cell membranes. Schwann cells cocultured with granule cells had a 30-fold increase in the labeling index over Schwann cells cultured alone, suggesting that the mitogen is located on the granule cell surface. Inhibition of granule cell proteoglycan synthesi

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Li, Jun-Qin, Hui-Jie Jiang, Xiu-Yun Su, et al. "Schwann Cells Accelerate Osteogenesis via the Mif/CD74/FOXO1 Signaling Pathway In Vitro." Stem Cells International 2022 (January 13, 2022): 1–13. http://dx.doi.org/10.1155/2022/4363632.

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Schwann cells have been found to promote osteogenesis by an unclear molecular mechanism. To better understand how Schwann cells accelerate osteogenesis, RNA-Seq and LC-MS/MS were utilized to explore the transcriptomic and metabolic response of MC3T3-E1 to Schwann cells. Osteogenic differentiation was determined by ALP staining. Lentiviruses were constructed to alter the expression of Mif (macrophage migration inhibitory factor) in Schwann cells. Western blot (WB) analysis was employed to detect the protein expression. The results of this study show that Mif is essential for Schwann cells to pr

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Muir, D., S. Varon, and M. Manthorpe. "Schwann cell proliferation in vitro is under negative autocrine control." Journal of Cell Biology 111, no. 6 (1990): 2663–71. http://dx.doi.org/10.1083/jcb.111.6.2663.

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In healthy adult peripheral nerve, Schwann cells are believed to be generally quiescent. Similarly, cultures of isolated rat sciatic nerve Schwann cells hardly proliferate in serum-supplemented medium. The possibility that Schwann cells negatively regulate their own proliferation was supported by the demonstration that conditioned media from Schwann cell cultures inhibited the proliferation of mitogen-stimulated test cultures. The inhibition could be complete, was dose dependent, and was exhibited when the test Schwann cells were under the influence of different types of mitogens such as chole

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Kim, Muwoong, Hyosun Kim, Dogyeong Kim, et al. "Heme Oxygenase 1 in Schwann Cells Regulates Peripheral Nerve Degeneration Against Oxidative Stress." ASN Neuro 11 (January 2019): 175909141983894. http://dx.doi.org/10.1177/1759091419838949.

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During Wallerian degeneration, Schwann cells lose their characteristic of myelinating axons and shift into the state of developmental promyelinating cells. This recharacterized Schwann cell guides newly regrowing axons to their destination and remyelinates reinnervated axons. This Schwann cell dynamics during Wallerian degeneration is associated with oxidative events. Heme oxygenases (HOs) are involved in the oxidative degradation of heme into biliverdin/bilirubin, ferrous iron, and carbon monoxide. Overproduction of ferrous iron by HOs increases reactive oxygen species, which have deleterious

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Carey, D. J., M. S. Todd, and C. M. Rafferty. "Schwann cell myelination: induction by exogenous basement membrane-like extracellular matrix." Journal of Cell Biology 102, no. 6 (1986): 2254–63. http://dx.doi.org/10.1083/jcb.102.6.2254.

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Exposing rat Schwann cells co-cultured with nerve cells to a reconstituted basement membrane induced the formation of myelin segments by Schwann cells. This occurred in a serum-free culture medium in which, in the absence of this matrix, Schwann cells proliferate but fail to differentiate. This reconstituted basement membrane was prepared from solubilized extracellular matrix proteins synthesized by a basement membrane-producing murine tumor. The major constituents of this reconstituted matrix are collagen type IV, laminin, heparan sulfate proteoglycan, entactin, and nidogen. The matrix also e

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Sheela, S., V. M. Riccardi, and N. Ratner. "Angiogenic and invasive properties of neurofibroma Schwann cells." Journal of Cell Biology 111, no. 2 (1990): 645–53. http://dx.doi.org/10.1083/jcb.111.2.645.

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Neurofibromas are benign tumors from patients with von Recklinghausen Neurofibromatosis (NF1) that are comprised primarily of Schwann cells. These Schwann cells are found both in association with axons and in the extracellular matrix that is prevalent in neurofibromas, and in which fibroblasts are also abundant. An unresolved question has been whether cells in neurofibromas are normal cells or are intrinsically abnormal. We have tested the hypothesis that cells in neurofibromas are abnormal and have shown that neurofibroma Schwann cells, unlike normal Schwann cells, promote angiogenesis in the

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Oliveira, Rosane B., Maria T. Ochoa, Peter A. Sieling, et al. "Expression of Toll-Like Receptor 2 on Human Schwann Cells: a Mechanism of Nerve Damage in Leprosy." Infection and Immunity 71, no. 3 (2003): 1427–33. http://dx.doi.org/10.1128/iai.71.3.1427-1433.2003.

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ABSTRACT Nerve damage is a clinical hallmark of leprosy and a major source of patient morbidity. We investigated the possibility that human Schwann cells are susceptible to cell death through the activation of Toll-like receptor 2 (TLR2), a pattern recognition receptor of the innate immune system. TLR2 was detected on the surface of human Schwann cell line ST88-14 and on cultured primary human Schwann cells. Activation of the human Schwann cell line and primary human Schwann cell cultures with a TLR2 agonist, a synthetic lipopeptide comprising the N-terminal portion of the putative Mycobacteri

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Huang, Zhong, Rebecca Powell, Svenja Kankowski, James B. Phillips, and Kirsten Haastert-Talini. "Culture Conditions for Human Induced Pluripotent Stem Cell-Derived Schwann Cells: A Two-Centre Study." International Journal of Molecular Sciences 24, no. 6 (2023): 5366. http://dx.doi.org/10.3390/ijms24065366.

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Adult human Schwann cells represent a relevant tool for studying peripheral neuropathies and developing regenerative therapies to treat nerve damage. Primary adult human Schwann cells are, however, difficult to obtain and challenging to propagate in culture. One potential solution is to generate Schwann cells from human induced pluripotent stem cells (hiPSCs). Previously published protocols, however, in our hands did not deliver sufficient viable cell numbers of hiPSC-derived Schwann cells (hiPSC-SCs). We present here, two modified protocols from two collaborating laboratories that overcome th

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Wang, Jiayi, Shunyi Lu, Ya Yuan, et al. "Inhibition of Schwann Cell Pyroptosis Promotes Nerve Regeneration in Peripheral Nerve Injury in Rats." Mediators of Inflammation 2023 (April 25, 2023): 1–12. http://dx.doi.org/10.1155/2023/9721375.

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Background. Peripheral nerve injury (PNI) is one of the most debilitating injuries, but therapies for PNI are still far from satisfactory. Pyroptosis, a recently identified form of cell death, has been demonstrated to participate in different diseases. However, the role of pyroptosis of Schwann cells in PNI remains unclear. Methods. We established a rat PNI model, and western blotting, transmission electron microscopy, and immunofluorescence staining were used to confirm pyroptosis of Schwann cells in PNI in vivo. In vitro, pyroptosis of Schwann cells was induced by lipopolysaccharides (LPS)+a

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Grove, Matthew, Noboru H. Komiyama, Klaus-Armin Nave, Seth G. Grant, Diane L. Sherman, and Peter J. Brophy. "FAK is required for axonal sorting by Schwann cells." Journal of Cell Biology 176, no. 3 (2007): 277–82. http://dx.doi.org/10.1083/jcb.200609021.

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Signaling by laminins and axonal neuregulin has been implicated in regulating axon sorting by myelin-forming Schwann cells. However, the signal transduction mechanisms are unknown. Focal adhesion kinase (FAK) has been linked to α6β1 integrin and ErbB receptor signaling, and we show that myelination by Schwann cells lacking FAK is severely impaired. Mutant Schwann cells could interdigitate between axon bundles, indicating that FAK signaling was not required for process extension. However, Schwann cell FAK was required to stimulate cell proliferation, suggesting that amyelination was caused by i

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Kim, H. A., B. Ling, and N. Ratner. "Nf1-deficient mouse Schwann cells are angiogenic and invasive and can be induced to hyperproliferate: reversion of some phenotypes by an inhibitor of farnesyl protein transferase." Molecular and Cellular Biology 17, no. 2 (1997): 862–72. http://dx.doi.org/10.1128/mcb.17.2.862.

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We have developed a potential model of Schwann cell tumor formation in neurofibromatosis type 1 (NF1). We show that mouse Schwann cells heterozygous or null at Nf1 display angiogenic and invasive properties, mimicking the behavior of Schwann cells from human neurofibromas. Mutations at Nf1 are insufficient to promote Schwann cell hyperplasia. Here we show that Schwann cell hyperplasia can be induced by protein kinase A activation in mutant cells. Removal of serum from the culture medium also stimulates hyperplasia, but only in some mutant cells. After serum removal, clones of hyperproliferatin

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Bolin, L. M., and E. M. Shooter. "Neurons regulate Schwann cell genes by diffusible molecules." Journal of Cell Biology 123, no. 1 (1993): 237–43. http://dx.doi.org/10.1083/jcb.123.1.237.

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Successful peripheral nerve regeneration and functional recovery require the reestablishment of the neuron-Schwann cell relationship in the regenerating rat sciatic nerve, neurons differentially regulate Schwann cell genes. The message for the low-affinity NGF receptor, p75NGFR, is induced in Schwann cells distal to the injury and is repressed as regenerating axons make contact with these cells. The inverse is true for mRNA of the myelin gene P0; expression decreases distal to injury and increases as new axons contact Schwann cells and a program of myelination is initiated. Using an in vitro c

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Ratner, N., R. P. Bunge, and L. Glaser. "A neuronal cell surface heparan sulfate proteoglycan is required for dorsal root ganglion neuron stimulation of Schwann cell proliferation." Journal of Cell Biology 101, no. 3 (1985): 744–54. http://dx.doi.org/10.1083/jcb.101.3.744.

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Axons of dorsal root ganglion neurons express on their surfaces one or more proteins which are mitogenic for Schwann cells (Salzer, J., R. P. Bunge, and L. Glaser, 1980, J. Cell Biol., 84:767-778). Incubation of co-cultures of dorsal root ganglion neurons and Schwann cells with 4-methylumbelliferyl-beta-D-xyloside, an inhibitor of proteoglycan biosynthesis, decreases the mitogenic response of the Schwann cell by over 95%. The effect of the beta-D-xyloside has been localized to the neurons; pretreatment of neurons but not of Schwann cells with the inhibitor causes a marked reduction of the mito

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Sherman, Larry S., Tilat A. Rizvi, Saikumar Karyala, and Nancy Ratner. "Cd44 Enhances Neuregulin Signaling by Schwann Cells." Journal of Cell Biology 150, no. 5 (2000): 1071–84. http://dx.doi.org/10.1083/jcb.150.5.1071.

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We describe a key role for the CD44 transmembrane glycoprotein in Schwann cell–neuron interactions. CD44 proteins have been implicated in cell adhesion and in the presentation of growth factors to high affinity receptors. We observed high CD44 expression in early rat neonatal nerves at times when Schwann cells proliferate but low expression in adult nerves, where CD44 was found in some nonmyelinating Schwann cells and to varying extents in some myelinating fibers. CD44 constitutively associated with erbB2 and erbB3, receptor tyrosine kinases that heterodimerize and signal in Schwann cells in r

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Eccleston, P. A., P. G. Bannerman, D. E. Pleasure, J. Winter, R. Mirsky, and K. R. Jessen. "Control of peripheral glial cell proliferation: enteric neurons exert an inhibitory influence on Schwann cell and enteric glial cell DNA synthesis in culture." Development 107, no. 1 (1989): 107–12. http://dx.doi.org/10.1242/dev.107.1.107.

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Neuronal membranes from rat dorsal root ganglia provide a mitogenic signal to cultured Schwann cells and it has been suggested this is an important factor in regulating Schwann cell numbers during development. In this study, the influence of enteric neurons on the DNA synthesis of both Schwann cells and enteric glia has been investigated as well as the effect of axonal membrane fractions (axolemma) on enteric glia. The proliferation rate of rat Schwann cells and enteric glia was assessed in culture using [3H]thymidine uptake and autoradiography in combination with immunolabelling to identify c

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Bernier, G., Y. De Repentigny, M. Mathieu, S. David, and R. Kothary. "Dystonin is an essential component of the Schwann cell cytoskeleton at the time of myelination." Development 125, no. 11 (1998): 2135–48. http://dx.doi.org/10.1242/dev.125.11.2135.

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A central role for the Schwann cell cytoskeleton in the process of peripheral nerve myelination has long been suggested. However, there is no genetic or biological evidence as yet to support this assumption. Here we show that dystonia musculorum (dt) mice, which carry mutations in dystonin, a cytoskeletal crosslinker protein, have hypo/amyelinated peripheral nerves. In neonatal dt mice, Schwann cells were arrested at the promyelinating stage and had multiple myelinating lips. Nerve graft experiments and primary cultures of Schwann cells demonstrated that the myelination abnormality in dt mice

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Seilheimer, B., E. Persohn, and M. Schachner. "Antibodies to the L1 adhesion molecule inhibit Schwann cell ensheathment of neurons in vitro." Journal of Cell Biology 109, no. 6 (1989): 3095–103. http://dx.doi.org/10.1083/jcb.109.6.3095.

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To investigate whether neural adhesion molecules are involved in neuron-induced Schwann cell differentiation, cocultures of pure dorsal root ganglion neurons, and Schwann cells were maintained in the presence of antibodies to evaluate possible perturbing effects. Several parameters characteristic of differentiating Schwann cells were studied, such as transition of spindle-shaped to flattened, i.e., more epithelioid morphology, association with neuronal cell bodies, ensheathment of neurites, production of basal lamina and collagen fibrils, and expression of the myelin associated glycoprotein (M

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Ma, Ki H., and John Svaren. "Epigenetic Control of Schwann Cells." Neuroscientist 24, no. 6 (2018): 627–38. http://dx.doi.org/10.1177/1073858417751112.

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The journey of Schwann cells from their origin in the neural crest to their ensheathment and myelination of peripheral nerves is a remarkable one. Their apparent static function in enabling saltatory conduction of mature nerve is not only vital for long-term health of peripheral nerve but also belies an innate capacity of terminally differentiated Schwann cells to radically alter their differentiation status in the face of nerve injury. The transition from migrating neural crest cells to nerve ensheathment, and then myelination of large diameter axons has been characterized extensively and sev

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