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1

Vieira da Cunha, Marcelo Lemos, Denildo César Amaral Veríssimo, Roberta Rehder, Daniel Dutra Cavalcantti, Cassio Zottis Grapiglia, and Luis Alencar Biurrum Borba. "Schwanoma Vestibular de Crescimento Rápido." JBNC - JORNAL BRASILEIRO DE NEUROCIRURGIA 22, no. 4 (2018): 198–204. http://dx.doi.org/10.22290/jbnc.v22i4.1073.

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A história natural dos schwanomas vestibulares ainda não é totalmente conhecida, mas a maioria destas lesões tende ao crescimento lento, algumas vezes sem qualquer manifestação clínica durante toda a vida do indivíduo, sendo em ocasiões achado de autópsias. Consideráveis avanços no conhecimento da anatomia da base do crânio, assim como os recursos tecnológicos de eletrofisiologia, como a monitorização intra-operatória têm possibilitado índices crescentes de preservação funcional do nervo facial e da audição. Devido a isso, a ressecção cirúrgica completa da lesão permanece sendo o tratamento de
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2

Dwivedi, Ashish Kumar, Shashi Kant Jain, and Ashok Gandhi. "Rare variant of misme syndrome – a case report with review of literature." Romanian Neurosurgery 30, no. 3 (2016): 444–50. http://dx.doi.org/10.1515/romneu-2016-0069.

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Abstract MISME syndrome, also known as neurofibromatosis type-2 (NF2), stands for multiple inherited schwannomas, meningiomas, and ependymomas (MISME) in the peripheral and central nervous system. It is a rare disorder of autosomal dominant inheritance due to mutations of a tumor-suppressor gene on the chromosome 22q12. Clinically, it is characterized by multiple benign tumors arising in both the central and the peripheral nervous system, particularly from the bilateral vestibular nerve in more than 90% of the patients and more than two thirds of them develop spinal tumors. Simultaneous occurr
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3

Kosugi, Eduardo M., Rodrigo P. Tangerina, Gabriel C. Dib, Hugo V. L. Ramos, and Norma O. Penido. "Schwanoma vestibular como causa de surdez súbita." Revista Brasileira de Otorrinolaringologia 70, no. 6 (2004): 795–99. http://dx.doi.org/10.1590/s0034-72992004000600015.

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A Surdez Súbita (SS) é um sintoma causado por mais de 60 doenças diferentes, dentre elas, o Schwanoma Vestibular (SV). Shaia & Sheehy (1976) apresentaram uma incidência de 1% de SV em 1220 casos de SS. Não há características específicas para o diagnóstico do SV, sendo a ressonância magnética (RM) o exame de escolha. OBJETIVO: Verificar a real incidência de SV em casuísticas de SS com a realização de RM. FORMA DE ESTUDO: Coorte transversal. MATERIAL E MÉTODO: Estudo prospectivo com a realização de RM com contraste de gadolínio em todos os pacientes com SS do serviço de urgência em Otorrinol
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4

Datta, Pran Gopal, Nasima Akhtar, Abirvab Naha, and Anindita Datta. "Schwanoma of tonsil." Bangladesh Medical Research Council Bulletin 46, no. 2 (2020): 142–44. http://dx.doi.org/10.3329/bmrcb.v46i2.49025.

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Background: Schwannoma is mostly benign lesion that originates from the Schwannoma cells that cover the myelinated nerve fibers. Schwannoma arising from the tonsil are very rare. In head and neck region the incidence rate of schwannoma is between 25 to 45%. In most of the cases vestibular nerve followed by a parapharyngeal space is involved. It is also known as neurilemmoma.
 Objective: To diagnoses and manage the case of a Schwannoma of Tonsil.
 Findings: A case of tonsillar schwannoma in a 42 years old males was reported. The patient presented with unilateral enlargement of left to
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5

Pereyra, Walter J. Fagundes, Alonso Luis De Sousa, Karlo Faria Nunes, and Deborah Nunes De Angeli. "Delayed facial nerve palsy after vestibular schwannoma surgery." JBNC - JORNAL BRASILEIRO DE NEUROCIRURGIA 20, no. 1 (2018): 84–88. http://dx.doi.org/10.22290/jbnc.v20i1.727.

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Background: Facial nerve dysfunction may occur immediately after vestibular schwanoma surgery. Electromyographyc monitoring of motor cranial nerves during cerebellopontine angle surgery has become an essential tool. Although delayed onset of facial nerve dysfunction hours to months following vestibular schwanoma surgery are rare. Case description: We describe the case of a 70-years-old male who was admitted with a left side tinnitus and hearing loss of the last 3 years. Magnetic resonance imaging (MRI) T1-weighted demonstrated an isointensity lesion, 30mm in diameter, at the left cerebello-pon
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6

Schaedler, Anne, and David Hawkins. "Audiologic Management of a Patient with a Sudden Hearing Loss and Vestibular Schwannoma in the Contralateral Ear." Journal of the American Academy of Audiology 19, no. 03 (2008): 210–14. http://dx.doi.org/10.3766/jaaa.19.3.4.

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The case of a 59-year-old male with a sudden-onset sensorineural hearing loss in one ear and an incidental finding of an intracanalicular vestibular schwannoma in the contralateral, normally hearing ear is reported. The patient was successfully fitted with a hearing aid in the ear with the sudden hearing loss, which notably had very poor word recognition. The questionable value of word-recognition scores in determining hearing aid candidacy is discussed. The importance of considering nonaudiologic factors in determining hearing aid candidacy is also highlighted. Se reporta el caso de una mujer
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7

Shelfer, Janet, David Zapala, and Larry Lundy. "Fall Risk, Vestibular Schwannoma, and Anticoagulation Therapy." Journal of the American Academy of Audiology 19, no. 03 (2008): 237–45. http://dx.doi.org/10.3766/jaaa.19.3.8.

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Elderly patients with balance problems are at high risk for falls. When these same patients are also on anticoagulants, the consequences of a fall can be serious. Anticoagulant therapy increases the risk of cerebral hemorrhage. Even mild head trauma can cause a fatal cerebral hemorrhage when anticoagulants are used. However, this risk needs to be weighed against the possibility of spontaneous stroke. The decision to choose anticoagulant therapy can become even more complicated if the patient has an increased risk of falling. A case is presented of an 87-year-old female with balance problems, i
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8

Radwan, Hesham, Mark Eisenberg, Jonathan Knisely, Maged Ghaly, and Michael Schulder. "SURG-23OUTCOMES IN PATIENTS WITH VESTIBULAR SCHWANOMA AFTER SUBTOTAL RESECTION AND ADJUVANT RADIOSURGERY." Neuro-Oncology 17, suppl 5 (2015): v219.3—v219. http://dx.doi.org/10.1093/neuonc/nov235.23.

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9

Goto, Fumiyuki, Hironari Kobayashi, Akira Saito, et al. "Compensatory changes in static and dynamic subjective visual vertical in patients following vestibular schwanoma surgery." Auris Nasus Larynx 30, no. 1 (2003): 29–33. http://dx.doi.org/10.1016/s0385-8146(02)00110-4.

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10

Fong, Brendan, Garni Barkhoudarian, Patrick Pezeshkian, Andrew T. Parsa, Quinton Gopen, and Isaac Yang. "The molecular biology and novel treatments of vestibular schwannomas." Journal of Neurosurgery 115, no. 5 (2011): 906–14. http://dx.doi.org/10.3171/2011.6.jns11131.

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Vestibular schwannomas are histopathologically benign tumors arising from the Schwann cell sheath surrounding the vestibular branch of cranial nerve VIII and are related to the NF2 gene and its product merlin. Merlin acts as a tumor suppressor and as a mediator of contact inhibition. Thus, deficiencies in both NF2 genes lead to vestibular schwannoma development. Recently, there have been major advances in our knowledge of the molecular biology of vestibular schwannomas as well as the development of novel therapies for its treatment. In this article the authors comprehensively review the recent
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11

Bandlish, Deepak, Nilay Biswas, and Sumit Deb. "Staging in giant vestibular schwannoma surgery: A two consecutive day technique for complete resection in basic neurosurgical setups." Journal of Neurosciences in Rural Practice 05, no. 03 (2014): 225–30. http://dx.doi.org/10.1055/s-0039-1700319.

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ABSTRACT Introduction: Vestibular schwannomas constitute 8% of all intracranial tumors. A majority of vestibular schwannomas are sporadic and unilateral. Giant vestibular schwannomas are seen in our country due to the late diagnosis and long duration of symptoms before diagnosis. These giant schwannomas are challenging to manage as most of the patients are having brainstem compression. Materials and Methods: Twelve cases of a giant vestibular schwannoma were operated in our department between May 2011 and December 2012. Vestibular schwannomas with a maximal diameter of more than 4 cm were defi
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12

Chou, Dean, Prakash Sampath, and Henry Brem. "Hemorrhagic vestibular schwannoma: an unusual clinical entity." Neurosurgical Focus 5, no. 3 (1998): E14. http://dx.doi.org/10.3171/foc.1998.5.3.15.

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Hemorrhagic vestibular schwannomas are rare entities, with only a few case reports in the literature during the last 25 years. The authors review the literature on vestibular schwannoma hemorrhage and the presenting symptoms of this entity, which include headache, nausea, vomiting, sudden cranial nerve dysfunction, and ataxia. A very unusual case is presented of a 36-year-old man, who unlike most of the patients reported in the literature, had clinically silent vestibular schwannoma hemorrhage. The authors also discuss the management issues involved in more than 1000 vestibular schwannomas tre
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13

Mehta, Gautam U., Michael J. Feldman, Herui Wang, Dale Ding, and Prashant Chittiboina. "Unilateral vestibular schwannoma in a patient with schwannomatosis in the absence of LZTR1 mutation." Journal of Neurosurgery 125, no. 6 (2016): 1469–71. http://dx.doi.org/10.3171/2015.11.jns151766.

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The presence of vestibular schwannomas has long been considered an exclusion criterion for the diagnosis of schwannomatosis. Recently, 2 cases of vestibular schwannoma were reported in patients with schwannomatosis, leading to a revision of the diagnostic criteria for this genetic disorder. Overall, the relative infrequency of vestibular schwannomas in schwannomatosis is unexplained, and the genetics of this uncommon phenomenon have not been described. The authors report on a family with clinical manifestations consistent with schwannomatosis, including 4 affected members, that was identified
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14

Neary, W. J., V. E. Newton, S. N. Laoide-Kemp, et al. "A clinical, genetic and audiological study of patients and families with unilateral vestibular schwannomas. I. Clinical features of neurofibromatosis in patients with unilateral vestibular schwannomas." Journal of Laryngology & Otology 110, no. 7 (1996): 634–40. http://dx.doi.org/10.1017/s0022215100134486.

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AbstractNinety-three patients with unilateral vestibular schwannomas were examined in a clinical, genetic and audiological study, to determine whether they had features associated with neurofibromatosis Type 1 or neurofibromatosis Type 2. In 91 families, one patient only was found to be affected with a unilateral vestibular schwannoma. Patients did have a few café-au-lait macules, but fewer than six in number. None of the patients satisfied the cutaneous diagnostic criteria for neurofibromatosis Type 1. Neither Lisch nodules nor presenile posterior subcapsular lenticular opacities or cortical
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15

Sanna, Mario, Manoj Agarwal, Yogesh Jain, Alessandra Russo, and Abdel Kader Taibah. "Transapical extension in difficult cerebellopontine angle tumours: preliminary report." Journal of Laryngology & Otology 117, no. 10 (2003): 788–92. http://dx.doi.org/10.1258/002221503770716214.

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Difficult cerebellopontine angle (CPA) tumours namely large/giant vestibular schwannomas, vestibular schwannomas with a significant anterior extension and meningiomas of the posterior surface of the petrous bone extending anterior to the internal auditory canal (IAC) have always posed a problem for the otoneurosurgeon. Modifications of the enlarged translabyrinthine approach (ETLA) specifically aimed at dealing with these tumours are not reported. The aim of this paper is to introduce the transapical extension of ETLA which involves increased circumferential drilling around the IAC beyond 270°
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16

Adib, Sasan Darius, Rocio Evangelista Zamora, and Marcos Tatagiba. "Extraordinary Tumor Growth Rates in Bilateral Meningioma-Vestibular Schwannoma Collision Tumors in a Patient with Neurofibromatosis Type 2: Case Report and Literature Review." SN Comprehensive Clinical Medicine 2, no. 12 (2020): 2976–80. http://dx.doi.org/10.1007/s42399-020-00626-0.

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AbstractCollision tumors seem to be an extraordinary pathology with unusual features. We sought to report the management of very fast-growing bilateral meningioma-vestibular schwannoma collision tumors in a patient with neurofibromatosis type 2. Both meningiomas and both vestibular schwannoma, when analyzed by volumetry, showed a very rapid growth rate (0.476–0.833 cm3 per month) in comparison with two meningiomas of other locations (0.132–0.233 cm3 per month). To the best of our knowledge, the growth rates of both vestibular schwannomas in the present case are the fastest that have been descr
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17

Jeon, Hyunjong, Heesung Chae, Haneul Lee, and Young Joon Seo. "A Case of Intralabyrinthine Schwannoma and Literature Review of the Cases Reported Previously in Korea." Korean Journal of Otorhinolaryngology-Head and Neck Surgery 63, no. 6 (2020): 270–75. http://dx.doi.org/10.3342/kjorl-hns.2019.00598.

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Vestibular schwannoma is a rare tumor that develops in the nerves responsible for vestibular function and hearing. It usually affects middle-aged people, and is diagnosed by hearing and imaging tests. In the majority of cases, it occurs in the retro-cochlear space and very rarely in the labyrinth. Several vestibular schwannoma localized in the labyrinth have been reported worldwide. Since then 5 cases have been reported. With advances in the imaging study, the diagnosis of intralabyrinthine schwannomas have increased. Our report describes the characteristics and treatments of intralabyrinthine
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18

Komazec, Zoran, Slobodanka Lemajic, and Ljiljana Vlaski. "Audiologic diagnostics of vestibular schwannoma." Medical review 57, no. 1-2 (2004): 81–85. http://dx.doi.org/10.2298/mpns0402081k.

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Introduction Vestibular schwannoma (acoustic neuroma) is a rare, but important cause of sensorineural hearing loss. Patients with asymmetric hearing loss, or unilateral tinnitus should be evaluated expeditiously, to prevent further neurological damage. Audiologic diagnostics Audiologic diagnostics represents the basic diagnosis for early detection of vestibular schwannoma. Patients with vestibular schwannomas may present with a variety of clinical features, including retrocochlear pattern of sensorineural hearing loss. Supraliminary audiometry, tympano- metry, stapedius reflex and otoacoustic
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Bhaskar, Mukesh, Rakesh Kumar, Sunil Singh, and M. Meel. "Vestibular Schwannoma with Contralateral Facial Nerve Palsy: A False Localizing Sign." Indian Journal of Neurosurgery 06, no. 02 (2017): 141–43. http://dx.doi.org/10.1055/s-0037-1602753.

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AbstractVestibular schwannomas are the most common cerebellopontine angle tumors. These tumors commonly present with ipsilateral dysfunction of acoustic, vestibular, trigeminal, and facial nerves. Vestibular schwannoma with involvement of contralateral facial nerve is very unusual, and whenever present, it is considered as a false localizing sign. It seems that displacement and distortion of the brainstem by the large mass lesion may lead to this atypical presentation. We report a case of vestibular schwannoma with contralateral abducens and facial nerve paresis.
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Herrera Lomonaco, Sandra, Karina María Ruiz Caez, and Anderson Julián Remolina López. "Schwannomas vestibulares bilaterales y neurofibromatosis tipo 2, reporte de 2 casos." Revista Chilena de Neurocirugía 42, no. 2 (2019): 123–27. http://dx.doi.org/10.36593/rev.chil.neurocir.v42i2.110.

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Los Schwanomas vestibulares (SV) son tumores benignos de las celulas de Schwann, corresponden a cerca del 6% de todos los tumores intracraneales, siendo en más del 95% unilaterales. Los Schwanomas vestibulares bilaterales del octavo par craneal son raros configurando el diagnostico de Neurofibromatosis tipo 2 (NF2), la cual es una enfermedad causada por la mutación del cromosoma 22; los SV bilaterales son la principal y más común manifestación de la NF2, presentando gran morbilidad. En comparación con los pacientes con SV unilaterales, los bilaterales se presentan en pacientes más jóvenes, tie
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Sen, Aloke, M. I. J. Khan, R. T. Ramsden, and J. E. Gillespie. "Stenosis of the internal auditory meatus masquerading as bilateral vestibular schwannomas: a cautionary tale." Journal of Laryngology & Otology 119, no. 12 (2005): 995–97. http://dx.doi.org/10.1258/002221505775010689.

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Stenotic malformations of the internal auditory meatus (IAM) are rare. They are known to symptomatically mimic vestibular schwannomas leading to potential diagnostic error. We present a case (along with literature review) where a stenotic IAM was clinically and radiologically misdiagnosed as a vestibular schwannoma.
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Halum, Stacey L., Christy B. Erbe, David R. Friedland, and Phillip A. Wackym. "Gene Discovery Using a Human Vestibular Schwannoma cDNA Library Constructed from a Patient with Neurofibromatosis Type 2 (NF2)." Otolaryngology–Head and Neck Surgery 128, no. 3 (2003): 364–71. http://dx.doi.org/10.1067/mhn.2003.99.

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BACKGROUND: Despite a strong association of schwannomin/merlin gene mutations with vestibular schwannoma formation, the regulatory mechanisms and biologic pathways involved are still largely unknown. The hypothesis of this study is that the genesis and growth characteristics of neurofibromatosis type 2 (NF2)-associated vestibular schwannomas are determined by genetic alterations that vary in gene transcript expression; this transcript expression includes oncogenic gene products that may be identified by construction and sequencing of a cDNA library from NF2-associated vestibular schwannoma. ME
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Bi, Wenya, Michael Mooney, Seungwon Yoon, et al. "Variation in Coding Practices for Vestibular Schwannoma Surgery." Journal of Neurological Surgery Part B: Skull Base 80, no. 01 (2018): 096–102. http://dx.doi.org/10.1055/s-0038-1667124.

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Introduction Nationwide databases are frequently used resources for assessing practice patterns and clinical outcomes. However, analyses based on billing codes may be limited by the inconsistent application of current procedural terminology (CPT) codes to specific operations. We investigated the variability among commonly used CPT codes for vestibular schwannomas resection and sought to identify factors that underlie this variation. Methods The surgical procedure for 274 cases of vestibular schwannoma resections from two institutions was reviewed and classified as retrosigmoid, translabyrinthi
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Koo, Malcolm, Jen-Tsung Lai, Edward Yih-Liang Yang, Tien-Chen Liu, and Juen-Haur Hwang. "Incidence of Vestibular Schwannoma in Taiwan from 2001 to 2012: A Population-Based National Health Insurance Study." Annals of Otology, Rhinology & Laryngology 127, no. 10 (2018): 694–97. http://dx.doi.org/10.1177/0003489418788385.

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Objectives: Vestibular schwannomas, also known as acoustic neuromas, are slow-growing tumors that may lead to asymmetric hearing loss, unilateral tinnitus, and vertigo. Population-based data are lacking regarding the incidence of vestibular schwannoma in Asian populations. The aim of this study was to investigate the incidence of vestibular schwannoma in Taiwan using data from a population-based health claim database. Subjects and Methods: Patients aged 20 years and over with incident cases of vestibular schwannoma between January 1, 2001, and December 31, 2012, were identified from the Longit
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Magliulo, G., A. Stasolla, D. Parrotto, and M. Marini. "Modified translabyrinthine approach and hearing preservation: imaging evaluation." Journal of Laryngology & Otology 121, no. 8 (2007): 736–41. http://dx.doi.org/10.1017/s0022215107006019.

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AbstractAim:To establish if the computed tomography (CT) and magnetic resonance imaging (MRI) appearances of the vestibule, after the removal of vestibular schwannoma by a modified translabyrinthine approach, correlate with a successful outcome, defined as hearing preservation.Materials and methods:Our study group consisted of 16 patients with vestibular schwannoma. All patients' pre-operative hearing was graded as class one or two according to the Gardner–Robertson scale. On MRI scans, the schwannoma, including the intracanalicular segment, were less than 2 cm in size in all the patients. The
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Ogungbo, Biodun, Damian Holliman, A. David Mendelow, and John Hill. "Co-existing cholesteatoma and vestibular schwannoma." Journal of Laryngology & Otology 116, no. 6 (2002): 460–63. http://dx.doi.org/10.1258/0022215021911077.

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A 69-year-old man presented with a cholesteatoma in the right mastoid process and a vestibular schwannoma at the left internal acoustic meatus. Cholesteatoma co-existing with a vestibular schwannoma has not been documented previously in the contemporary literature. The clinical dilemma in the managementof his progressive bilateral hearing loss is discussed. He presented with dizziness and bilateral hearing loss worse on the right side. Pressure over the mastoid process elicited vertigo and nystagmus. He had no history of previous operation or infection in the ear canal. Audiograms confirmed hi
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Li, Meihua, Jinhong Mei, Yiyun Li, Xueqin Tao, and Tao Hong. "Intracerebral Schwannoma Mimicking Meningioma: Case Report." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 40, no. 6 (2013): 881–84. http://dx.doi.org/10.1017/s0317167100016085.

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Intracranial schwannomas account for 8% of all primary brain tumors, approximately 80-90% of them being seen in the cerebellopontine angle in relation to the vestibular nerve. Schwannomas arising within brain parenchyma, unrelated to the cranial nerves, are extremely rare. To our knowledge, only 73 cases of intracerebral schwannoma have been described in the English-language literature so far,1-5 but only six cases of intracerebral schwannoma mimicking meningioma have been reported1-3 and there have been few reports regarding neuroradiological findings. Disagreement remains concerning the hist
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Libório dos Santos, Adriana Rodrigues Libório dos Santos, Silvia Mazzali Verst, Wilson Scappini Junior, et al. "Schwannoma of the Intermediate Nerve: A Rare Type of Cerebellopontine Angle Tumor." Revista Chilena de Neurocirugía 47, no. 1 (2021): 31–33. http://dx.doi.org/10.36593/revchilneurocir.v47i1.199.

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Abstract
 Background: Schwannoma of the Intermediate Nerve is rare. The most majority of Cerebellopontine angle (CPA) lesions are Vestibular Schwannomas.
 Case description: A 50-year-old woman presented with ear pain, facial palsy and hypoacusis. MRI revealed a CPA tumor. A left retrosigmoid approach and microsurgery was performed and the tumor origin was from the intermediate nerve. intraoperative neurophysiologic monitoring (MNIO) was used during the surgery. Conclusion: Schwannomas of the intermediate nerve is indistinguishable from vestibular schwannomas on preoperatory image, ho
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Jabbour, J., P. Earls, N. Biggs, G. Gracie, P. Fagan, and R. Bova. "Role of cyclins D1 and D3 in vestibular schwannoma." Journal of Laryngology & Otology 130, S1 (2015): S2—S10. http://dx.doi.org/10.1017/s0022215115001735.

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AbstractBackground:Vestibular schwannomas in younger patients have been observed to be larger in size and grow more quickly.Objective:This study aimed to evaluate the expression of three important cell cycle proteins, cyclin D1, cyclin D3and Ki-67, in vestibular schwannoma patients separated into two age groups: ≤40 years or >40 years.Method:Immunohistochemical detection of cyclin D1, cyclin D3and Ki-67 was undertaken in 180 surgically resected vestibular schwannomas.Results:The proliferation index of vestibular schwannomas was statistically higher in the ≤40 years age group compared to tha
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Swensson, Rubem Cruz, Rogério Poli Swensson, Fabio Eduardo Caramante Pizzini, Pedro Robson Boldorini, and José Jarjura Jorge Júnior. "Tumor do VIII nervo com apresentação incomum." Revista Brasileira de Otorrinolaringologia 74, no. 4 (2008): 628–31. http://dx.doi.org/10.1590/s0034-72992008000400024.

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Os Schwannomas vestibulares são responsáveis por 80 a 90% dos tumores do ângulo ponto-cerebelar. A atual incidência é estimada em 0,8% a 2,5% da população mundial. A hipoacusia unilateral e progressiva é o sintoma mais precoce e freqüente, sendo o tinido a segunda queixa mais comum. Estudos demonstram que apenas 5% dos pacientes com schwannoma vestibular têm exames audiométricos normais. No caso em foco é relatado hipoestesia da hemiface com diminuição do reflexo córneo palpebral ipsilateral, hipoestesia da porção póstero-superior do pavilhão auditivo (sinal de Hitzelberger positivo), diminuiç
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King, Andrew T., Scott A. Rutherford, Charlotte Hammerbeck-Ward, et al. "Malignant Peripheral Nerve Sheath Tumors are not a Feature of Neurofibromatosis Type 2 in the Unirradiated Patient." Neurosurgery 83, no. 1 (2017): 38–42. http://dx.doi.org/10.1093/neuros/nyx368.

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Abstract BACKGROUND The published literature suggests that malignant peripheral nerve sheath tumors (MPNST) occur at increased frequency in neurofibromatosis type 2 (NF2). A recent review based on incidence data in North America showed that 1 per 1000 cerebellopontine angle nerve sheath tumors were malignant. OBJECTIVE To determine whether MPNST occurred spontaneously in NF2 by reviewing our NF2 database. METHODS The prospective database consists of 1253 patients with NF2. One thousand and nine are known to be alive at last follow-up. The presence and laterality/pathology of vestibular schwann
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Suryanarayanan, R., R. T. Ramsden, S. R. Saeed, et al. "Vestibular schwannoma: role of conservative management." Journal of Laryngology & Otology 124, no. 3 (2009): 251–57. http://dx.doi.org/10.1017/s0022215109992362.

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AbstractObjective:To assess the outcome of conservative management of vestibular schwannoma.Study design:Observational study.Setting:Tertiary referral centre.Patients:Four hundred and thirty-six patients with vestibular schwannoma (490 tumours), including 327 sporadic tumours and 163 tumours in 109 patients with neurofibromatosis type two.Main outcome measures:The relationship of tumour growth to tumour size at presentation, and to certain demographic features.Results:The initial tumour size was significantly larger in the neurofibromatosis type two group (11 mm) than in the sporadic vestibula
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Basu, S., R. Youngs, and A. Mitchell-Innes. "Screening for vestibular schwannoma in the context of an ageing population." Journal of Laryngology & Otology 133, no. 8 (2019): 640–49. http://dx.doi.org/10.1017/s0022215119000963.

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AbstractObjectiveTo review the literature regarding screening for vestibular schwannoma in the context of demographic changes leading to increasing numbers of elderly patients presenting with asymmetric auditory symptoms.MethodsA systematic review of the literature was performed, with narrative synthesis and statistical analysis of data where appropriate.ResultsVestibular schwannomas diagnosed in patients aged over 70 years exhibit slower growth patterns and tend to be of smaller size compared to those tumours in younger age groups. This fact, combined with reduced life expectancy, renders the
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Donnelly, Martin J., Anne D. Cass, and Laurie Ryan. "False positive MRI in the diagnosis of small intracanalicular vestibular schwannomas." Journal of Laryngology & Otology 108, no. 11 (1994): 986–88. http://dx.doi.org/10.1017/s0022215100128683.

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AbstractThe current gold standard for diagnosing vestibular schwannomas is MRI with gadolinium-DTPA enhancement. This imaging modality is particularly useful in the detection of small intracanalicular tumours which can be missed by CT scanning. We present a case where MRI with enhancement suggested the presence of a 4 mm intracanalicular vestibular schwannoma. Surgical exploration of the internal auditory canal via a retrosigmoid approach, revealed no tumour, but inflammatory arachnoid matter around the vestibular nerve was found. A review of the audiological test results uncovered some result
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35

Schwartz, Marc S., Gregory P. Lekovic, Mia E. Miller, William H. Slattery, and Eric P. Wilkinson. "Translabyrinthine microsurgical resection of small vestibular schwannomas." Journal of Neurosurgery 129, no. 1 (2018): 128–36. http://dx.doi.org/10.3171/2017.2.jns162287.

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OBJECTIVETranslabyrinthine resection is one of a number of treatment options available to patients with vestibular schwannomas. Though this procedure is hearing destructive, the authors have noted excellent clinical outcomes for patients with small tumors. The authors review their experience at a tertiary acoustic neuroma referral center in using the translabyrinthine approach to resect small vestibular schwannomas. All operations were performed by a surgical team consisting of a single neurosurgeon and 1 of 7 neurotologists.METHODSData from a prospectively maintained clinical database were ex
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Betka, Jan, Eduard Zvěřina, Zuzana Balogová, et al. "Complications of Microsurgery of Vestibular Schwannoma." BioMed Research International 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/315952.

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Background. The aim of this study was to analyze complications of vestibular schwannoma (VS) microsurgery.Material and Methods. A retrospective study was performed in 333 patients with unilateral vestibular schwannoma indicated for surgical treatment between January 1997 and December 2012. Postoperative complications were assessed immediately after VS surgery as well as during outpatient followup.Results. In all 333 patients microsurgical vestibular schwannoma (Koos grade 1: 12, grade 2: 34, grade 3: 62, and grade 4: 225) removal was performed. The main neurological complication was facial ner
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Noguchi, Yoshihiro, Atsushi Komatsuzaki, Ichiro Yamada, Hideji Okuno, and Hidetoshi Haraguchi. "Vestibular schwannoma showing a dural tail on contrastenhanced magnetic resonance images." Journal of Laryngology & Otology 111, no. 9 (1997): 877–79. http://dx.doi.org/10.1017/s0022215100138873.

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AbstractThe dural tail on contrast-enhanced magnetic resonance (MR) images, frequently observed in meningiomas, has been used to distinguish between cerebellopontine angle meningiomas and vestibular schwannomas. We report on a 66-year-old female with vestibular schwannoma showing the dural tail on contrast-enhanced MR images. Histological examination revealed that the dural tail corresponded to the thickened dura mater comprising of collagen fibres and scattered hyalinization with no tumoral invasion.
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Thomas, J. Alex, William O. Bank, and John S. Myseros. "Glossopharyngeal schwannoma in childhood." Journal of Neurosurgery: Pediatrics 2, no. 2 (2008): 130–32. http://dx.doi.org/10.3171/ped/2008/2/8/130.

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Glossopharyngeal (that is, cranial nerve IX) schwannomas are extremely rare nerve sheath tumors that frequently mimic the more common vestibular schwannoma in their clinical as well as radiographic presentation. Although rare in adults, this tumor has not been reported in a child. The authors report the case of a 10-year-old boy who presented with several months of unilateral hearing loss. He was found to have a large right cerebellopontine angle tumor. Given the boy's primary complaint of hearing loss and the appearance of the lesion on imaging, the tumor was initially believed to be a schwan
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Springborg, L. K., J. B. Springborg, and J. Thomsen. "Hearing preservation after classical translabyrinthine removal of a vestibular schwannoma: case report and literature review." Journal of Laryngology & Otology 121, no. 1 (2006): 76–79. http://dx.doi.org/10.1017/s0022215106003598.

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The translabyrinthine approach is one of the favoured access routes for removal of vestibular schwannomas; however, total hearing loss in the operated ear is a predictable consequence. Here, we report a case in which a patient maintained serviceable hearing almost six years after classic translabyrinthine surgery. Possible explanations for the hearing preservation are discussed, as well as the feasibility of a modified translabyrinthine approach in attempting preservation of hearing following vestibular schwannoma surgery.
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Nicoucar, Keyvan, Shahan Momjian, John-Paul Vader, and Nicolas de Tribolet. "Surgery for large vestibular schwannomas: how patients and surgeons perceive quality of life." Journal of Neurosurgery 105, no. 2 (2006): 205–12. http://dx.doi.org/10.3171/jns.2006.105.2.205.

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Object The aim of this study was to assess the consequences of total removal of a large vestibular schwannoma on the patient’s symptoms and quality of life (QOL). Methods A questionnaire regarding preoperative and postoperative symptoms with measures of both daily and global QOL and a modified 36-Item Short Form Health Survey (SF-36) QOL instrument were sent to 103 patients who had undergone surgery via a retrosigmoid approach for total removal of a Grade III or IV vestibular schwannoma. In addition, 48 patients underwent follow-up clinical examinations to assess their conditions. Seventy-two
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Peng, K. A., and E. P. Wilkinson. "Optimal outcomes for hearing preservation in the management of small vestibular schwannomas." Journal of Laryngology & Otology 130, no. 7 (2016): 606–10. http://dx.doi.org/10.1017/s0022215116007969.

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AbstractObjective:To undertake a systematic review of the role of microsurgery, in relation to observation and stereotactic radiation, in the management of small vestibular schwannomas with serviceable hearing.Methods:The Medline database was searched for publications that included the terms ‘vestibular schwannoma’ and/or ‘acoustic neuroma’, occurring in conjunction with ‘hearing’. Articles were manually screened to identify those concerning vestibular schwannomas under 1.5 cm in greatest dimension. Thereafter, only publications discussing both pre-operative and post-operative hearing were con
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Silva, João Vitor da, Victor Lucas de Santana Cardoso, and Gerlan da Silva Rodrigues. "Schwannoma Vestibular / Vestibular Schwannoma." Brazilian Journal of Health Review 3, no. 6 (2020): 17248–53. http://dx.doi.org/10.34119/bjhrv3n6-145.

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43

Bovo, Nicolas, Shahan Momjian, Renato Gondar, Philippe Bijlenga, Karl Schaller, and Colette Boëx. "Sensitivity and Negative Predictive Value of Motor Evoked Potentials of the Facial Nerve." Journal of Neurological Surgery Part A: Central European Neurosurgery 82, no. 04 (2021): 317–24. http://dx.doi.org/10.1055/s-0040-1719026.

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Abstract Objective The objective of this study was to determine the performance of the standard alarm criterion of motor evoked potentials (MEPs) of the facial nerve in surgeries performed for resections of vestibular schwannomas or of other lesions of the cerebellopontine angle. Methods This retrospective study included 33 patients (16 with vestibular schwannomas and 17 with other lesions) who underwent the resection surgery with transcranial MEPs of the facial nerve. A reproducible 50% decrease in MEP amplitude, resistant to a 10% increase in stimulation intensity, was applied as the alarm c
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Prabhuraj, A. R., Nishanth Sadashiva, Santhosh Kumar, et al. "Hydrocephalus Associated with Large Vestibular Schwannoma: Management Options and Factors Predicting Requirement of Cerebrospinal Fluid Diversion after Primary Surgery." Journal of Neurosciences in Rural Practice 08, S 01 (2017): S027—S032. http://dx.doi.org/10.4103/jnrp.jnrp_264_17.

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ABSTRACT Objective: Obstructive hydrocephalus (HCP) related to vestibular schwannoma occurs in large tumors compressing the fourth ventricle. Symptoms related to HCP are expected to alleviate after resection of the tumor and decompression of the cerebrospinal fluid (CSF) pathways. However, some patients may require permanent cerebrospinal diversion even after surgery due to persistent HCP. In this study, the authors try to find out the factors associated with the requirement of CSF diversion after vestibular schwannoma surgery in cases of persistent HCP. Materials and Methods: This was a retro
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Agnihotri, Sameer, Isabel Gugel, Marc Remke, et al. "Gene-expression profiling elucidates molecular signaling networks that can be therapeutically targeted in vestibular schwannoma." Journal of Neurosurgery 121, no. 6 (2014): 1434–45. http://dx.doi.org/10.3171/2014.6.jns131433.

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ObjectVestibular schwannomas (VS) are common benign tumors of the vestibular nerve that cause significant morbidity. The current treatment strategies for VS include surgery or radiation, with each treatment option having associated complications and side effects. The transcriptional landscape of schwannoma remains largely unknown.MethodsIn this study the authors performed gene-expression profiling of 49 schwannomas and 7 normal control vestibular nerves to identify tumor-specific gene-expression patterns. They also interrogated whether schwannomas comprise several molecular subtypes using seve
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46

Koerbel, Andrei, Alireza Gharabaghi, Sam Safavi-Abbasi, Marcos Tatagiba, and Madjid Samii. "Evolution of vestibular schwannoma surgery: the long journey to current success." Neurosurgical Focus 18, no. 4 (2005): 1–6. http://dx.doi.org/10.3171/foc.2005.18.4.11.

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The extraordinary improvement of patient outcome after surgical treatment for vestibular schwannomas is relatively recent and has occurred mainly over the last 30 years. The introduction of microsurgical techniques has resulted in increasing degrees of precise anatomical and functional preservation of the facial and cochlear nerves. An expanded microsurgical technique accompanied by continuous electrophysiological monitoring has resulted in marked changes in the primary goals for this surgery. Whereas in the past the primary goal of vestibular schwannoma management was to preserve the patient'
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47

Khrais, T., G. Romano, and M. Sanna. "Nerve origin of vestibular schwannoma: a prospective study." Journal of Laryngology & Otology 122, no. 2 (2007): 128–31. http://dx.doi.org/10.1017/s0022215107001028.

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AbstractObjective:The origin of vestibular schwannoma has always been a matter of debate. The aim of our study was to identify the nerve origin of this tumour.Study design:Prospective case review. This study was conducted at Gruppo Otologico, a private referral centre for neurotology and skull base surgery.Methods:A total of 200 cases of vestibular schwannoma were included in the study. All the tumours were removed surgically utilising the translabyrinthine approach. The origin of the tumour was sought at the fundus of the internal auditory canal.Results:A total of 200 consecutive cases was in
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Pan, P., J. Huang, C. Morioka, G. Hathout, and S. M. El-Saden. "Cost analysis of vestibular schwannoma screening with contrast-enhanced magnetic resonance imaging in patients with asymmetrical hearing loss." Journal of Laryngology & Otology 130, no. 1 (2015): 21–24. http://dx.doi.org/10.1017/s0022215115002431.

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AbstractBackground:Vestibular schwannomas are a rare cause of asymmetrical hearing loss, and routine screening with magnetic resonance imaging can be costly. This paper reports results on vestibular schwannoma screening at our institution and compares the cost of screening to a utility of hearing benefit.Method:All screening examinations with magnetic resonance imaging performed for asymmetrical hearing loss between 2006 and 2011 were retrospectively reviewed. The cost per new vestibular schwannoma diagnosis was calculated. The cost per patient for those who benefitted from intervention was es
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49

Pollock, Bruce E., L. Dade Lunsford, Douglas Kondziolka, et al. "Vestibular schwannoma management." Journal of Neurosurgery 89, no. 6 (1998): 949–55. http://dx.doi.org/10.3171/jns.1998.89.6.0949.

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Object. The indications, operative findings, and outcomes of vestibular schwannoma microsurgery are controversial when it is performed after stereotactic radiosurgery. To address these issues, the authors reviewed the experience at two academic medical centers. Methods. During a 10-year interval, 452 patients with unilateral vestibular schwannomas underwent gamma knife radiosurgery. Thirteen patients (2.9%) underwent delayed microsurgery at a median of 27 months (range 7–72 months) after they had undergone radiosurgery. Six of the 13 patients had undergone one or more microsurgical procedures
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Gigliotti, Deanna, Brian Blakley, Paige Moore, and Jordan Hochman. "The Role for Imaging in the Investigation of Isolated Objective Vestibular Weakness." Otolaryngology–Head and Neck Surgery 161, no. 6 (2019): 1027–30. http://dx.doi.org/10.1177/0194599819877691.

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Objective Unilateral vestibular weakness has considerable potential etiologies. One source is a vestibular schwannoma. This article evaluates, in the absence of other symptoms and signs, if unilateral vestibular weakness is an analogue to asymmetric sensorineural hearing loss and serves as an indication for lateral skull base imaging. Study Design Retrospective chart review. Setting Academic tertiary center. Subjects and Methods All patients undergoing caloric assessment between January 1, 2012, and June 30, 2018, were investigated. Patients with unilateral vestibular weakness (a left-right di
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