Academic literature on the topic 'Science=2017-06-11'

Background:in SSc, PAH has a high morbidity and mortality burden. Therefore, screening and early detection are pivotal to achieve an early diagnosis of PAH.Objectives:to search the literature for all screening modalities for SSc-PAH in reference to right heart catheterization as diagnostic gold standard.Methods:papers from 2 previously published SLRs [22 fromGlaude et al(1) – from inception to 19/06/2012 - and 22 fromYoung et al 2018– from 20/06/2012 to 02/10/2017] were included. The articles’ database was integrated with a systematic search on Pubmed, EMBASE, Web of Science for papers published from 03/10/2017 to 31/12/2018. A total of 199 papers were reviewed and 32 were finally extracted. Bias risk was assessed through QUADAS2 tool.Results:167 papers were excluded from data extraction mainly for PAH screening non as main focus or for non-including SSc patients. The 32 papers extracted presented a low bias risk according to QUADAS2. Screening methods reported were:Echocardiographic parameters in 31/32 studies, in particular systolic pulmonary arterial pressure (sPAP) in 22 papers; 40 mmHg was the most frequently used cut-off (in 12/22 papers); sPAP was part of a composite algorithm in 9/22 papers. Among others, tricuspid regurgitation velocity (TRV) was used in 6/31 (as part of composite 5/6) and right atrial pressure (RAP) in 3/31 papers.Pulmonary function tests parameters in 22/32 papers, with % predicted Lung diffusion for carbon oxyde (DLco) in 21 papers, with a 50% cut-off in 11/21 and as part of composite algorithm in 13/21 studies. Moreover, walked distance at six minutes walking test was a screening parameter in 3/32 papers.Serum biomarkers in 12/32 papers, with anti-centromere antibodies (6/12), NT-proBNP (6/12) and uric acid (5/12) being the most frequently reported.Clinical parameters in 15/32 papers, with unexplained dyspnoea in 9/15 and telangiectasias in 5/15 papers.Composite algorithms were used in 18/32 manuscripts: among them, DETECT (5/18), ESC/ERS 2009 (4/18) or 2015 (3/18) guidelines, ASIG (2/18) e ITINER-air (1/18). In different cohorts, DETECT and ASIG showed higher sensitivity and negative predictive value than ESC/ERS 2009.Conclusion:in the literature, the screening of SSc-PAH is largely investigated by echocardiographic parameters. In particular, sPAP and TRV, both as single items or part of a composite algorithm, including also serum biomarkers, clinical and functional parameters, are the most frequent parameters evaluated.(supported by an Actelion Pharmaceuticals unrestricted research grant)References:[1]Gladue H, et al. Screening and diagnostic modalities for connective tissue disease-associated pulmonary arterial hypertension: a systematic review. Semin Arthritis Rheum. 2014 Feb;43(4):536-41.[2]Young A, et al. Update of screening and diagnostic modalities for connective tissue disease-associated pulmonary arterial hypertension. Semin Arthritis Rheum. 2019 Jun;48(6):1059-1067.Acknowledgments:(supported by an Actelion Pharmaceuticals unrestricted research grant)Disclosure of Interests:Cosimo Bruni Speakers bureau: Actelion, Eli Lilly, Giacomo De Luca Speakers bureau: SOBI, Novartis, Celgene, Pfizer, MSD, Maria Grazia Lazzaroni: None declared, Elisabetta Zanatta: None declared, Gemma Lepri: None declared, Marco Matucci-Cerinic Grant/research support from: Actelion, MSD, Bristol-Myers Squibb, Speakers bureau: Acetelion, Lilly, Boehringer Ingelheim

Background and Objectives: Coal mine injuries commonly occur, affecting both the safety and health of miners, and the normal operation of the coal mine. Accordingly, this study aimed to explore the regularity of injury and injury-related risk factors in coal mines in China so as to establish a scientific basis for reducing the incidence and promoting the prevention and control of injuries. Methods: A meta-analysis of casualty cases and injury-related risk factors from 1956 to 2017 in China was conducted utilizing data from six databases, including CNKI, Web of Science, PubMed, Medline, Embase, and Wanfang data. Summary estimates were obtained using random effects models. Results: There were statistically significant variations in coal mine accident types, types of work, injury sites, age, experience, months, and shifts (p < 0.001). Eight types of accidents were susceptible to the risk of injury, and the greatest risk was presented by roof-related accidents (odds ratio (OR) = 0.46, 95% confidence interval (CI) = 0.32–0.6). Coal miners and drillers were at a greater risk of injury (OR = 0.39, 95% CI = 0.35–0.44; OR = 0.22, 95% CI = 0.17–0.26, respectively). The extremities and the soft tissues of the skin were at the greatest risk of injury (OR = 0.44, 95% CI = 0.3–0.58; OR = 0.23, 95% CI = 0.1–0.48, respectively). Compared with other ages, miners aged 21–30 were at a greater risk of injury (21–30 years, OR = 0.45, 95% CI = 0.42–0.47; 31–40 years, OR = 0.29, 95% CI = 0.25–0.32; <20 years, OR = 0.13, 95% CI = 0.03–0.23; >40 years, OR = 0.17, 95% CI = 0.09–0.25). Compared with other miners, those with 6–10 years of experience were at a greater risk of injury (6–10 years, OR = 0.29, 95% CI = 0.25–0.32; 2–5 years, OR = 0.33, 95% CI = 0.25–0.41; <1 year, OR = 0.22, 95% CI = 0.08–0.33; >11 years, OR = 0.22, 95% CI = 0.17–0.27). During the months of July to September, the risk of injury was elevated (7–9th months, OR = 0.32, 95% CI = 0.25–0.39; 10–12th months, OR = 0.24, 95% CI = 0.16–0.31; 1st–3rd months, OR = 0.22, 95% CI = 0.16–0.28; 4–6th months, OR = 0.21, 95% CI = 0.16–0.27). In the three-shift work system, the risk of injury was higher during night shifts (22:00–06:00, OR = 0.43, 95% CI = 0.3–0.56; 14:00–22:00, OR = 0.3, 95% CI = 0.23–0.27; 06:00–14:00, OR = 0.27, 95% CI = 0.18–0.35). Conclusions: The results of this research study reveal that coal mine injuries are prevalent among coal miners. These injuries are often related to the age, experience, months of work, and the three-shift work system of miners.

The article deals with the notion of manipulation in advertising slogans of fast food restaurants. It focuses on techniques and means of language influence on the recipient. The article shows results of the study of 239 advertising slogans of fast food restaurants in English-speaking countries (a total number of 104 companies). Different language patterns which are used in advertising slogans and aimed at persuasion of customers on the subconscious level, are defined and analyzed; among them the most numerous are language patterns which create statements with distortions, deletions, and generalizations manifesting themselves in a variety of forms. The research also describes manipulative language patterns specifically related to advertising, such as unique selling proposition or life values. The article also shows quantitative proportions of the use of each pattern, as well as patterns used by the most successful and less successful restaurants. The most frequent of the manipulative language patterns are lost performatives, mind reading, and comparisons. The techniques of life values, mind reading, and antithesis are more common in advertising slogans of top restaurants compared to less popular ones. Individual slogans frequently manifest the use of more than one linguistic pattern of manipulation. References Alder, H. (2002). Handbook of NLP: A Manual for Professional Communicators. New York: Routledge Bandler, R, Grinder, J. (1975). The Structure of Magic (1st edition). USA: Science & Behavior Books. Burton, K., Ready, R. (2010). Neuro-linguistic Programming for Dummies. West Sussex: Wiley Ciotti, G. 5 Ways to Develop a Unique Selling Proposition Convince&Convert. Dec. 2013. Retrieved from http://www.convinceandconvert.com/digital-marketing/5-ways-to-develop-a-unique-selling-proposition/ Colbert, B. (2012). From Ordinary to Extraordinary – How to Live An Exceptional Life. Ireland: Gill Danciu, V. (2014). Manipulative marketing: persuasion and manipulation of the consumer through advertising. Theoretical and Applied Economics, 9(2), 19-34. Гесюк Ю. Застосування нейролінгвістичного програмування в рекламі. Медіапростір. 2014, № 5. С. 122-126. Горин С. НЛП: Техники россыпью. //Метафора экспромтом. Под ред. Н. Либман. М.: КСП+, 2004. С. 269-268. Каліщук Д. Психолінгвістичні прийоми мовленнєвого маніпулювання у політичному дискурсі «Гра у простонародність» // Вісник Харківського національного університету імені В.Н. Каразіна. 2012. Вып. 1022, № 71. С. 59-63. Кутуза Н. Маніпулятивні прийоми в рекламному та політичному дискурсах: лінгвістичні аспекти // Науковий вісник Херсонського державного університету. 2006. № 3. С. 285-288. Lapšanská, J. (2006). The language of advertising with the concentration on the linguistic means and the analysis of advertising slogans. Diploma thesis, Bratislava: Comenius University in Bratislava, Faculty of Education. Romanenko, E. (2014). Linguistic analysis of on-line advertising in English. Bachelor thesis, Prague: Charles University in Prague, Faculty of education. Vaknin, S. (2008). The Big Book of NLP Techniques. Charleston: BookSurge. References (translated and transliterated) Hesiuk, Y. (2014). Zastosuvannia neirolinhvistychnoho prohramuvannia v reklami [The usage of neurolinguistic programming in advertising]. Mediaprostir, 5, 122-126. Horyn, S. (2004). NLP: Tehnyky rossypiu. [Writing techniques]. In: Metafora Expromtom, (pp. 269-268). N. Libman (ed). Moscow: KSP+. Kalischuk, D. (2012). Psykholinhvistychni pryiomy movlennievoho manipuliuvannia u politychnomu dyskursi. “Hra u prostonarodnist” [Psycholinguistic Techniques of Speech Manipulation in Political Discourse. “Plain Folks”]. Journal of V.N.Karazin National University of Kharkiv, 1022(71), 59-63. Kutuza, N. (2006). Manipuliatyvni pryiomy v reklamnomu ta politychnomu dyskursakh: linhvistychni aspekty [Manipulative techniques in advertisement and political discourse]. Informational-Methodical Journal of Kherson State University, 3, 285-288. Sources Advertising. 2017. In Business dictionary.com. Retrieved November 9, 2017, from http://www.businessdictionary.com/definition/advertising.html Advertising. 2017. In Cambridge dictionary. com. Retrieved November 9, 2017, from https://dictionary.cambridge.org/dictionary/english/advertising Advertising. 2017. In Longman Dictionary of Contemporary English. Retrieved November 9, 2017, from https://www.ldoceonline.com/dictionary/advertising Burger King Slogans. (2017). Retrieved September 09, 2017, from http://www.thinkslogans.com/ company/burger-king/ Eagle Boys Pizza Seeks Expansion In India. (2013, August 26). Retrieved September 10, 2017, from https://news.franchiseindia.com/Eagle-Boys-Pizza-seeks-expansion-in-India-2017 Eat Good And Feel Good. (2016, June 21). Retrieved September 09, 2017, from http://www.eatwithhop. com/2016/06/eat-good-and-feel-good-extreme-pita.html Famous restaurant slogans and taglines. (2017). Retrieved August 09, 2017, from http://sloganshub.org/restaurants-slogans/ Fast Food Slogans List A – F. (2017). Retrieved July 23, 2017, from http://www.ffood. net/fast_food_slogans.htm Fast food slogans. (2017). Retrieved September 01, 2017, from http://www.textart.ru/advertising/ slogans/fast-food.html Fish and chips slogans. (2017). Retrieved June 12, 2017, from http://www.textart.ru/advertising/ slogans/fish-and-chips.html Five Guys Prices. (2017, May 20). Retreived June 20, 2017, from https://fastfoodinusa.com/five-guys-prices/ Hunt, Kristin. “10 things you didn't know about steak 'n shake” Thrillist. May, 2014. Retrieved July 10, 2017 from https://www.thrillist.com/eat/nation/a-brief-history-of-steak-n-shake Manipulation. 2017. In Dictionary.com. Retrieved November 9, 2017, from http://www.dictionary. com/browse/manipulation?s=t Manipulation. 2017. In Oxford Learner’s Dictionary. Retrieved November 9, 2017, from https://www.oxfordlearnersdictionaries.com/definition/english/manipulation?q=manipulation Papa Murphy's Cowboy Pizza TV Commercial, 'Love at 425 Degrees. (2013). Retrieved August 09, 2017, from https://www.ispot.tv/ad/7d6y/papa-murphys-cowboy-pizza-love-at-425-degrees Perrotte, Ashley. “America’ dinner is always open”. Prezi. Oct, 2015. Retrieved July 20, 2017, from https://prezi.com/vn99xnq6may_/americas-diner-is-always-open/ Pizza Hut. (2017). Retrieved August 11, 2017, from http://www.bestslogans.com/v/237117/makin-it-great-again-and-again-pizza-hut/ Pret a manager. (2017). Retrieved June 09, 2017, from https://www.pinterest.com/pin/ 535013630709601320/ Rella, E. “We're lovin' it: McDonald's slogans over the last five decades” Finance. Mar. 2016. Retrieved June 09, 2017, from https://www.aol.com/article/2016/03/01/were-lovin-it-mcdonalds-slogans-over-the-last-five-decades/21320937/ https://genius.com/Fast-food-slogans-annotated Restaurant Slogans. (2017). Retrieved August 09, 2017, from http://www.advergize.com/slogans-list/restaurant-slogans/ Restaurants. (2013, March 03). Retrieved June 03, 2017, from . http://www.morrisanderson.com/ resource-center/entry/Chains-last-links-Nostalgia-helps-keep-once-thriving-restaurant-franchises-/ Sarodh, Waiz. “Krispy Kreme: Slogans & Humble Beginnings” Advergize Empowering Marketing, Mar. 2017. Retrieved August 09, 2017, from http://www.advergize.com/ advertising/krispy-kreme-slogans-and-humble-beginnings/ Smaktakula. “Commercials We Do Not Like: Bad Andy” Promethean Times. Feb. 2011. Retrieved September 22, 2017, from https://prometheantimes.com/2011/02/22/commercials-we-do-not-like-badandy/ Smith, Nelson. “Boston Pizza: Sink Your Teeth into This Delicious 6% Yield” Baystreet, May. 2017. 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The aim of this study was to describe the international academic mobility experienced by the Fishing Engineering students in other countries. The data was collected through an electronic semi-structured questionnaire hosted on an electronic platform by Google. A total of nine students answered the questionnaire, in which they chose countries such as France, Spain, Ireland, Canada, the United States and Australia to study abroad in. The student’s satisfaction with the Science without Borders Program (SwB) was extremely positive, where all the interviewees stated that they had learned the language from the hosting country. In relation to the negative aspects, 67% of the interviewees pointed out that they struggled to understand the language in the beginning of the academic mobility, and 78% of the students said that they missed their families during the student mobility period. In conclusion, the academic mobility performed by students from the Fishing Engineering course was rated as excellent, and as a unique and an enriching opportunity, both in professional and personal aspects.ResumoO trabalho teve como objetivo discutir sobre a mobilidade acadêmica vivenciada por estudantes de Engenharia de Pesca em outros países. A coleta de dados foi feita através de um questionário eletrônico semiestruturado, hospedado em uma plataforma eletrônica de formulários da Google. Um total de nove discentes respondeu ao questionário, realizando a mobilidade na França, Espanha, Irlanda, Canadá, Estados Unidos e Austrália. A satisfação dos estudantes com o Programa Ciência sem Fronteiras (CsF) foi positiva, todos os entrevistados afirmaram terem aprendido o idioma do país que escolheram. Em relação aos aspectos negativos, 67% dos entrevistados apontaram que tiveram dificuldades no entendimento do idioma do país no início da mobilidade acadêmica e 78% sentiram saudade da família no período da mobilidade. Concluindo, a mobilidade acadêmica realizada por discentes do Curso de Engenharia de Pesca foi classificada como excelente, sendo uma experiência única e enriquecedora tanto pelo lado profissional, quanto pessoal.Palavras-chave: Educação, Aprendizado, Internacionalização, Programa Ciência sem Fronteiras.Keywords: Education, Learning, Internationalization.ReferencesALTBACH, P. G. Comparative Higher Education: Knowledge, the University, and Development. Hong Kong: University of Hong Kong, p. 240, 1998.ANDRADE, B. P. S. O “Ciência sem Fronteiras” pelo olhar da comunidade acadêmica: O caso da Unifal-mg e da Unifei. 2018. 185f. Dissertação (Mestrado em Divulgação Científica e Cultural). Universidade Estadual de Campinas, Instituto de Estudos de Linguagem, Campinas, SP, 2018. AVEIRO, T. M. M. O programa Ciência sem Fronteiras como ferramenta de acesso à mobilidade internacional. Tear: Revista de Educação Ciência e Tecnologia, Canoas, v.3, n.2, 2014.BEINE, M.; NOEL, R.; RAGOT, L. Determinants of the international mobility of students. Economics of Education Review, mar. 2014. BETT, D. B. Jovens universitários e intercâmbio acadêmico. 2012. 34f. Monografia (Especialização em Psicologia terminalidade em Terapia Cognitiva e Comportamental). Universidade Federal do Rio Grande do Sul, Instituto de Psicologia, Porto Alegre, 2012.BRASIL. Decreto n.° 7.642, de 13 de dezembro de 2011, Institui o Programa Ciência sem Fronteiras. Diário Oficial da República Federativa do Brasil, Brasília, DF, n. 239, p. 7, seção1, 14 dez. 2011a.BRASIL. Ministério da Ciência, Tecnologia e Inovação. Ministério da Educação. Conselho Nacional de Desenvolvimento Científico e Tecnológico Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. Programa Ciência sem Fronteiras: um programa especial de mobilidade internacional em ciência, tecnologia e inovação. Documento Conjunto CAPES-CNPq. Julho, 2011b. 67p. Disponível em: http://www.capes.gov.br/images/stories/download/ Ciencia-sem Fronteiras_DocumentoCompleto_julho2011.pdfBRASIL. Ministério Da Ciência Tecnologia e Inovação. Estratégia Nacional de Ciência, Tecnologia e Inovação 2012 – 2015: Balanço das Atividades Estruturantes de 2011. Brasília, DF, 2012. Disponível em: https://livroaberto.ibict.br/218981.pdf . Acesso em: 25 abr. 2018.BRASIL. Programa Ciência sem Fronteiras. Dados Chamadas Graduação Sanduíche 2011-2014. Brasília, 2014. Disponível em: http://www.cienciasemfronteiras.gov.br/web/csf/dados-chamadas-graduacao-sanduiche. Acesso em: 21 abr. 2018.BRASIL. Programa Ciência sem Fronteiras. Painel de Controle do Programa 2016. Disponível em: http://www.cienciasemfronteiras.gov.br/web/csf/painel-de-controle . Acesso em: 18 jul. 2018.BRUNO, R. C. et al. Mobilidade internacional para educação superior: perfil sociodemográfico e educacional de imigrantes. Almanaque Multidisciplinar de Pesquisa, Universidade Unigranrio, ano III, v.1, n.1, 2016.COMISSÃO DE CIÊNCIA E TECNOLOGIA, COMUNICAÇÃO E INFORMÁTICA. Senado Federal. Relatório. Brasília. 2015. Disponível em: http://legis.senado.leg.br/sdleg-getter/documento/download/9f8bccb3-c880-408c-9667-96582f07fa84 Acesso em: 20 maio 2018.CORREIA-LIMA, M. C.; RIEGEL, V. Mobilidade acadêmica made in South: refletindo sobre as motivações de estudantes brasileiros e colombianos. Magis Revista Internacional de Investigación en Educación, v.8, n.16, p.109-132, 2015. DOI: http://dx.doi.org/10.11144/Javeriana.m8-16.mamsCRUZ, V. X. A. PROGRAMA CIÊNCIA SEM FRONTEIRAS: Uma avaliação da política pública de internacionalização do ensino superior sob a perspectiva do Paradigma Multidimensional. Dissertação (Mestrado em Administração Pública). 2016. 209f. Universidade Federal de Goiás, Faculdade de Ciências e Tecnologia – FCT, Goiânia, GO, 2016.CUTTI, L. et al. Programa Ciência sem Fronteiras: relato de experiências. Revista Eletrônica de Educação, v.11, n.3, p.1020-1033, set./dez., 2017. DOI: http://dx.doi.org/10.14244/198271991897 DALMOLIN, I. S. et al. Intercâmbio acadêmico cultural internacional: uma experiência de crescimento pessoal e científico. Rev Bras Enferm, Brasília, v. 66, n.33. p. 442-447, 2013.FERREIRA, I.G.; CARREIRA, L. B.; BOTELHO, N. M. Mobilidade internacional na graduação em medicina: relato de experiência. ABCS Health Sci., v. 42, n.2, p.115-119, 2017. DOI: http://dx.doi.org/10.7322/abcshs.v42i2.1013INSTITUTE FOR INTERNATIONAL EDUCATION – IIE. Open Doors Report 2015: Fast Facts New York, 2015. Disponível em: https://www.iie.org/Research-and-Insights/Open-Doors/Fact-Sheets-and-Infographics/Fast-Facts. Acesso em: 15 nov. de 2017.INSTITUTE OF INTERNATIONAL EDUCATION – IIE. International student totals by place of origin, 2012/13 – 2015/16. Open Doors Report on International Educational Exchange, 2016. Disponível em: https://www.iie.org/Research-and-Insights/Open-Doors/Data/International-Students/Places-of-Origin. Acesso em: 15 nov. de 2017.INSTITUTE OF INTERNATIONAL EDUCATION – IIE. Open Doors Report 2017: Fast Facts Disponível em: https://www.iie.org/Research-and-Insights/Open-Doors/Fact-Sheets-and-Infographics/Fast-Facts. Acesso em: 01 ago. 2018.INTERNATIONAL TRADE ADMINISTRATION – ITA. 2016 Top Markets Report Education: Brazil Country Case Study. Disponível em: https://www.trade.gov/topmarkets/pdf/Education_Brazil.pdf. Acesso em: 15 nov. de 2017.KNIGHT, J. Internationalization remodeled: definition, approaches, and rationales. Journal of Studies in International Education, v. 1, p. 5-31, 2004.LIMA, M. C.; RIEGEL, V. A influência da mobilidade acadêmica sobre a formação dos jovens. UniRitter, Negócios e Talentos, v.2 , n.11, 2013.MAJID, S. et al. Motivations for studying abroad and adjustment challenges faced by international students in Singapore. Acad. J. Educ. Res., v.5, n.8, p. 223-235, 2017. DOI: http://dx.doi.org/10.15413/ajer.2017.0712MANÇOS, G. R.; COELHO, F. S. Internacionalização da Ciência Brasileira: subsídios para avaliação do programa Ciência sem Fronteiras. Revista Brasileira de Políticas Públicas e Internacionais, p.73, 2017.MARANHÃO, C. M. S.; DUTRA, C. I.; MARANHÃO, R. K. Internacionalização do ensino superior: um estudo sobre barreiras e possibilidades. Administração: Ensino e Pesquisa, Rio de Janeiro, v. 18, n. 1, p. 09–38, jan-abr 2017. DOI: http://dx.doi.org/10.13058/raep.2017.v18n1.458MARQUES, F. Experiência encerrada. Revista Pesquisa Fapesp, ed. 256, 27-29, jun. 2017. Disponível em http://revistapesquisa.fapesp.br/2017/06/19/experiencia-encerrada . Acesso em: 21 nov. 2017.MARTINS, V.; MONTAGUE, A.; SILVA, P. B. Cooperação internacional para mobilidade estudantil: o caso da Umesp e da Zuyd. Revista de Educação do Cogeime, ano 26, n. 50, jan/jun 2017.MOROSINI, M. C.; AMARAL, G. M. Avaliação da mobilidade acadêmica universitária: A perspectiva dos alunos intercambistas. In: SIMPÓSIO AVALIAÇÃO DA EDUCAÇÃO SUPERIOR, 2015, Porto Alegre. Anais... Porto Alegre, 17 e 18 set. 2015. OLIVEIRA, A. L.; FREITAS, M. E. Motivações para mobilidade acadêmica internacional: a visão de alunos e professores universitários. Educação em Revista, Belo Horizonte, v.32, n.03, p. 217-246, jul/set 2016. DOI: http://dx.doi.org/10.1590/0102-4698148237PEREIRA, V. Relatos de uma viagem: uma análise feita pelos bolsistas sobre o programa Ciência Sem Fronteiras. Revista Perspectivas do Desenvolvimento: um enfoque multidimensional, v. 03, no 4, jul. 2015.PROLO, I.; VIEIRA, R. C. O programa Ciência sem Fronteiras e as Universidades Brasileiras: Uma política pública a celebrar? In: Seminários em Administração (SEMEAD), XX, 2017, LOCAL. Anais..., nov. 2017. ISSN 2177-3866.SÁ, C. M. The Rise and Fall of Brazil’s Science Without Borders. International Higher Education, n.85, p.17-18, 2016. STALLIVIERI, L. As dinâmicas de uma nova linguagem intercultural na mobilidade acadêmica internacional. 2009. 235f. Tese (Doutorado em Línguas Modernas). Universidade Del Salvador, Buenos Aires, Argentina, 2009.SANTOS, S. R. et al. Turismo e intercâmbio: contribuições para a formação discente nos cursos de graduação das instituições de ensino superior de São Luís, Maranhão. Cultur, ano 08, n. 2, jul. 2014.SEHNEM, P. R.; LUNA, J. M. F. Os egressos do Programa Ciência sem Fronteiras pela percepção dos seus professores. Revista Eletrônica de Educação, v. 12, n. 1, p. 104-119, jan./abr., 2018. DOI: http://dx.doi.org/10.14244/198271991919UNITED NATIONS ORGANIZATION FOR EDUCATION, SCIENCE AND CULTURE (UNESCO). Recueil des donneés mondiales sur l'éducation: statistiques comparées sur l'éducation dans le monde. Montreal: Unesco, 2009. Dispo­nível em: http://www.uis.unesco.org/Library/Documents/ged09-fr.pdf Acesso em: 01 abri 2019.e3633105

Computational Thinking (CT) is a set of logical-operational cognitive skills or processes of reasoning, based on Computer Science. Abstraction, pattern recognition, algorithmic reasoning, and decomposition are examples of some of these skills that form the four pillar of CT. Some researchers have considered these skills as useful, and even mandatory to to cognitive development of the schoolchildren. In this paper, we present practical aspects and the possible contributions of CT in the development of competence of reading and interpreting English texts. Didactic interventions were carried out in high school classes of a public school, supported by the Bring Your Own Device (BYOD) approach, in which the students used their own smartphones. During these interventions, the students developed concept maps and podcasts, performed online exercises and the traditional exam, all of that composed the set of evaluation instruments. It was possible to understand that the CT skills are intrinsically present and contributed to the development of the reading and writing skills in English. According to testimonials, we highlight that the BYOD approach provided new conceptions and perspectives on the use of electronic equipment in function of the students’ learning.ResumoO Raciocínio Computacional (RC) é um conjunto de habilidades ou processos cognitivos lógico-operacionais de raciocínio, fundamentadas na Ciência da Computação. Abstração, reconhecimento de padrões, raciocínio algorítmico e decomposição são exemplos de algumas dessas habilidades que formam os quatro pilares do RC. Alguns pesquisadores consideram essas habilidades úteis, e até mesmo fundamentais, para o desenvolvimento cognitivo dos estudantes. Nesse sentido, este relato de experiência tem por objetivo apresentar aspectos práticos e possíveis contribuições do RC no desenvolvimento da competência de leitura e interpretação de textos de diferentes naturezas na disciplina de língua inglesa. Para isso, realizaram-se intervenções didáticas em uma turma do ensino médio de uma escola pública, apoiadas na abordagem Bring Your Own Device ou, simplesmente, BYOD, em que os estudantes usaram seus próprios aparelhos celulares. Durante o desenvolvimento das intervenções, os estudantes construíram mapas conceituais e podcasts, realizarem exercício online e a tradicional prova, os quais compuseram o conjunto de instrumentos avaliativos do bimestre. Por meio dessas intervenções, foi possível identificar como as habilidades do RC estiveram intrinsecamente presentes e contribuíram para o desenvolvimento da competência de leitura e escrita em língua inglesa, elencada pelos Parâmetros Curriculares Nacionais. Conforme relatos, além da articulação didática com o RC, a abordagem BYOD proporcionou à professora e aos estudantes novas concepções e perspectivas sobre o uso de equipamentos eletrônicos em função da aprendizagem deles mesmos.Palavras-chave: Raciocínio computacional, Ensino de inglês, Mobile learning, Educação em computação.Keywords: Computational thinking, English teaching, Mobile learning, Computer science education.ReferencesALBERTA Education. School Technology Branch. Bring your own device: a guide for schools. 2012. Disponível em:http://education.alberta.ca/admin/technology/research.aspx. Acesso em: 01 fev. 2017.ALLAN, Walter; COULTER, Bob; DENNER, Jill; ERICKSON, Jeri; LEE, Irene; MALYN-SMITH, Joyce; MARTIN, Fred. Computational thinking for youth. White Paper for the ITEST Learning Resource Centre na EDC. Small Working Group on Computational Thinking (CT), 2010. Disponível em: http://stelar.edc.org/publications/computational-thinking-youth. 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Children's stunting is a problem because it is associated with an increased risk of pain and death, suboptimal brain development resulting in late motor development, and inhibition of mental growth. This study aims to examine the factors that influence the occurrence of stunting and risk in children in Indonesia. The research method used is a traditional review. The results of the review found that many factors cause the high incidence of stunting in toddlers, including energy intake, birth weight, maternal knowledge level, family economic status, parental parenting, and food security. WHO estimates the prevalence of stunting worldwide at 22 percent or as many as 149.2 million in 2020. According to the Indonesian Nutritional Status Study (SSGI) results of the Ministry of Health, the prevalence of stunting in children under five in Indonesia reached 24.4% in 2021. The prevalence of stunting of toddlers in Indonesia continues to show a decline. In 2018 the prevalence of stunting toddlers was still 30.8%. Then, it dropped to 27.7 in 2019 and continued to fall to 24.4% in SSGI 2024. The government even targets to drop to 14% by the end of 2024. Furthermore, WHO also recommends reducing stunting by 3.9% per year to meet the target of 40% stunting reduction by 2025. Keywords: Indonesian children; stunting data; causes of stunting; the prevalence of stunting References: Aguayo, V. M., & Menon, P. (2016). Stop stunting: Improving child feeding, women’s nutrition and household sanitation in South Asia. Maternal and Child Nutrition, 12, 3–11. https://doi.org/10.1111/mcn.12283 Chaparro, C. (2017). FANTA-Guatemala-ENSMI-Report_March 2012. Creswell, J. W. (2014). Research Design: Qualitative, Quantitative and Mixed Methods Approaches (4th ed.). Thousand Oaks, CA: Sage. da Silva, I. C. M., França, G. V., Barros, A. J. D., Amouzou, A., Krasevec, J., & Victora, C. G. (2018). 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Introduction: Acute myeloid leukemia (AML) is characterized by both aberrant proliferation and differentiation arrest at hematopoietic progenitor stages 1,2. AML relies upon de novo nucleotide synthesis to meet a dynamic metabolic landscape and to provide a sufficient supply of nucleotides and other macromolecules 3,4. Hence, we hypothesized that inhibition of de novo nucleotide synthesis would lead to depletion of the nucleotide pool and pyrimidine starvation in leukemic cells compared to their non-malignant counterparts and impact proliferative and differentiation inhibition pathways. PTC299 is an inhibitor of dihydroorotate dehydrogenase (DHODH), a rate limiting enzyme for de novo pyrimidine nucleotide synthesis that is currently in a clinical trial for the treatment of AML. Aim: We investigated the pre-clinical activity of PTC299 against AML in primary AML blasts and cytarabine-resistant cell lines. To confirm that PTC299 effects are due to inhibition of de novo pyrimidine nucleotide synthesis for leukemic growth, we specifically tested the impact of uridine and orotate rescue. In addition, a comprehensive analysis of alteration of metabolic signaling in PI3K/AKT pathways, apoptotic signatures and DNA damage responses were analyzed by Mass cytometry based proteomic analysis (CyTOF) and immunoblotting. The potential clinical relevance of DHODH inhibition was confirmed in an AML-PDX model. Results: The IC50s for all tested cell lines (at 3 day) and primary blasts (at 5-7 day) were in a very low nanomolar range: OCI-AML3 -4.43 nM, HL60 -59.7 nM and primary samples -18-90 nM. Treatment of AML in cytarabine-resistant cells demonstrated that PTC299 induced apoptosis, differentiation, and reduced proliferation with corresponding increase in Annexin V and CD14 positive cells (Fig.1). PTC299-induced apoptosis and inhibition of proliferation was rescued by uridine and orotate. To gain more mechanistic insights, we used an immunoblotting and mass cytometry (CyTOF) based approach to analyze changes in apoptotic and cell signaling proteins in OCI-AML3 cells. Apoptotic pathways were induced (cleaved PARP, cleaved Caspase-3) and DNA damage responses (TP53, γH2AX) and the PI3/AKT pathway were downregulated in response to PTC299. In isogenic cell lines, p53-wildtype cells were sustained and an increased DNA damage response with corresponding increase in apoptosis in comparison to p53-deficient cells was shown. (Fig.2) In a PDX mouse model of human AML, PTC299 treatment improved survival compared to mice treated with vehicle (median survival 40 days vs. 30 days, P=0.0002) (Fig.3). This corresponded with a reduction in the bone marrow burden of leukemia with increased expression of differentiation markers in mice treated with PTC299 (Fig.3). Conclusion: PTC299 is a novel dihydroorotate dehydrogenase (DHODH) inhibitor that triggers differentiation, apoptosis and/or inhibition of proliferation in AML and is being tested in a clinical trials for the treatment of acute myeloid malignancies. Reference: 1. Thomas D, Majeti R. Biology and relevance of human acute myeloid leukemia stem cells. Blood 2017; 129(12): 1577-1585. e-pub ahead of print 2017/02/06; doi: 10.1182/blood-2016-10-696054 2. Quek L, Otto GW, Garnett C, Lhermitte L, Karamitros D, Stoilova B et al. Genetically distinct leukemic stem cells in human CD34- acute myeloid leukemia are arrested at a hemopoietic precursor-like stage. The Journal of experimental medicine 2016; 213(8): 1513-1535. e-pub ahead of print 2016/07/06; doi: 10.1084/jem.20151775 3. Villa E, Ali ES, Sahu U, Ben-Sahra I. Cancer Cells Tune the Signaling Pathways to Empower de Novo Synthesis of Nucleotides. Cancers (Basel) 2019; 11(5). e-pub ahead of print 2019/05/22; doi: 10.3390/cancers11050688 4. DeBerardinis RJ, Chandel NS. Fundamentals of cancer metabolism. Sci Adv 2016; 2(5): e1600200. e-pub ahead of print 2016/07/08; doi: 10.1126/sciadv.1600200 Disclosures Weetall: PTC Therapeutic: Current Employment. Sheedy:PTC therapeutics: Current Employment. Ray:PTC Therapeutics Inc.: Current Employment. Konopleva:Genentech: Consultancy, Research Funding; Rafael Pharmaceutical: Research Funding; Ablynx: Research Funding; Ascentage: Research Funding; Agios: Research Funding; Kisoji: Consultancy; Eli Lilly: Research Funding; AstraZeneca: Research Funding; Reata Pharmaceutical Inc.;: Patents & Royalties: patents and royalties with patent US 7,795,305 B2 on CDDO-compounds and combination therapies, licensed to Reata Pharmaceutical; AbbVie: Consultancy, Research Funding; Calithera: Research Funding; Cellectis: Research Funding; Amgen: Consultancy; Stemline Therapeutics: Consultancy, Research Funding; Forty-Seven: Consultancy, Research Funding; F. Hoffmann La-Roche: Consultancy, Research Funding; Sanofi: Research Funding. Andreeff:Amgen: Research Funding; Daiichi-Sankyo; Jazz Pharmaceuticals; Celgene; Amgen; AstraZeneca; 6 Dimensions Capital: Consultancy; Daiichi-Sankyo; Breast Cancer Research Foundation; CPRIT; NIH/NCI; Amgen; AstraZeneca: Research Funding; Centre for Drug Research & Development; Cancer UK; NCI-CTEP; German Research Council; Leukemia Lymphoma Foundation (LLS); NCI-RDCRN (Rare Disease Clin Network); CLL Founcdation; BioLineRx; SentiBio; Aptose Biosciences, Inc: Membership on an entity's Board of Directors or advisory committees. Borthakur:BioLine Rx: Consultancy; BioTherix: Consultancy; Nkarta Therapeutics: Consultancy; Treadwell Therapeutics: Consultancy; Xbiotech USA: Research Funding; Polaris: Research Funding; AstraZeneca: Research Funding; BMS: Research Funding; BioLine Rx: Research Funding; Cyclacel: Research Funding; GSK: Research Funding; Jannsen: Research Funding; Abbvie: Research Funding; Novartis: Research Funding; Incyte: Research Funding; PTC Therapeutics: Research Funding; FTC Therapeutics: Consultancy; Curio Science LLC: Consultancy; PTC Therapeutics: Consultancy; Argenx: Consultancy; Oncoceutics: Research Funding.

Empirical studies proved that good corporate governance had a positive link to the success of an organization. Good in directing and managing organizational processes, structures, and information mean satisfaction guaranteed was given to all stakeholders. Essential factor like working atmosphere may be considered when looking into corporate governance as well as organizational success. However, limited literature focused on the importance of communication climate and its connection to corporate governance and organizational success. Hence, this study looked into the predicting effect of communication climate to perceived corporate governance and organizational success. A total of ninety-eight rank and file employees voluntarily participated in accomplishing three questionnaires such as the Communication Climate Inventory by Costigen & Schiedler; Corporate Governance Survey adapted from Wickramanayake’s Seven Characteristics of Corporate Governance; and Organizational Success Survey adapted from Ilyas & Rafig used to measure communication climate, corporate governance, and organizational success respectively. Results revealed that communication climate was a predictor of perceived corporate governance and organizational success. This implied that the role of supervisors in setting work conditions was essential on how rank and file employees perceived corporate governance and organizational success.ReferencesAbdu Rashid, M., Azman bin Othman, M., Zainudin bin Othman, M., Ain bt Arshad, F. (2015). The influence of work environment on employees job performance: a case study of Administrative staff in a manufacturing industry. 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Working conditions and employees’ productivity in manufacturing companies in sub-saharan African context: case of Somalia. Educational Research International. 2, 67-78.Wickramanayake, K. (2007, March 06). Seven Characteristics of Corporate Governance. [Blog post]. https://www.wview.org

The ability to disclose fraud essential to researched due to problems in the field. In Indonesia, there have been some cases where the company experienced massive losses because the auditors were not able to reveal the fraud. The purpose of this study was to analyze the influence of experience, audit fee, professionalism, and independence of auditors against the ability to disclose fraud. Fraud is an irregularity or unlawful act for the benefit of personal / group interests, either directly or indirectly detrimental to another party. According to the Indonesian Institute of Accountants (IAI) fraud is misstatement or loss of amount or disclosure in intentional financial statements. The result of the research shows that auditors experience variable with value of sig 0,011 has a positive influence on the ability to disclose fraud. The auditor audit fee variable with the value of sig 0,007 has a positive influence on the ability to disclose fraud. Keywords : Auditors experience, audit fee, professionalism, independence, the ability to disclose fraud References: https://www.wartaekonomi.co.id/read145257/ketika-skandal-fraud-akuntansi-menerpa-british-telecom-dan- pwc.html https://economy.okezone.com/read/2019/06/28/320/2072245/kronologi-kasus-laporan-keuangan-garuda- indonesia-hingga-kena-sanksi Agustina, R. D., & Pratomo, D. (2019). Pengaruh Fraud Pentagon Dalam Mendeteksi Kecurangan Pelaporan Keuangan. Jurnal Ilmiah Manajemen, Ekonomi, & Akuntansi (MEA), 3(1), 44–62. https://doi.org/10.31955/mea.vol3.iss1.pp44-62 Anggriawan. (2014). Pengaruh Pengalaman Kerja Skeptisme Profesional dan Tekanan Waktu Terhadap Kemampuan Aufitor Dalam Mendeteksi Fraud ( Studi Empiris Pada Kantor Akuntan Publik Di Diy) Eko. III. Arens, A. A., Elder, R. J., & Beasley, M. S. (2014). Auditing & Jasa Assurance. Aulia. (2013). Pengaruh Pengalaman Indepenensi Dan Skeptisme Profesional Auditor Terhadap Pendeteksi Kecurangan. (206082004000). Biksa, I. A. I., & Wiratmaja, I. D. N. (2016). Pengaruh Pengalaman, Independensi, Skeptisme Profesional Auditor pada pendeteksian kecurangan. E-Jurnal Akuntansi Universitas Udayana, 17(3), 2384–2415. Boynton, W. C. (2004). Modern Auditing (7th ed.). Bowerman, et al (2017). Business Statistics In Practice (8th ed). Carolita, M. K., & Rahardjo, S. N. (2012). Pengaruh Pengalaman Kerja, Independensi, Objektifitas, Integritas, Kompetensi, dan Komitmen Organisasi Terhadap Kualitas Hasil Audit. (Studi Pada Kantor Akuntan Publik di Semarang). 1(2002), 1–11. Christiawan, Y. J. (2002). Kompetensi Dan Independensi Akuntan Publik : Refleksi Hasil Penelitian Empiris. Jurnal Akuntansi Dan Keuangan, 4(2), 79–92. https://doi.org/10.9744/jak.4.2.pp.79-92 Cooper, D. R., & Schindler, P. S. (2017). Metode Penelitian Bisnis (12th ed.). Salemba Empat. Fachruddin. (2017). Pengaruh Fee Audit, Pengalaman Kerja,Dan Pengalaman Kerja, Dan Independensi uditor Terhadap Kualitas Audit Pada Kantor Akuntan Publik DI Kota Medan Wan. 3(2), 144–155. George, C. S. (2005). The History of Management Thought. Paperback. Ghozali, I. (2016). Aplikasi Analisis Multivariete (8th ed.). Badan Penerbit Universitas Diponegoro. Hartan, T. H. (2016). Pengaruh Skeptisme Profesional, Independensi dan Kompetensi Terhadap Kemampuan Auditor Mendeteksi Kecurangan (Studi Empiris Pada Inspektorat DIY). Audit. Herliansyah, Y., & Ilyas, M. (2014). Pengaruh Pengalaman Auditor terhadap Penggunaan Bukti Tidak Relevan dalam Auditor Judgement. Simposium Nasional Akuntansi IX, 1–15. Hermawan, A., & Wulandari, R. (2019). Pengaruh Pengalaman Dan Keahlian Terhadap Ketepatan Pemberian Opini Audit Melalui Skeptisisme Profesional Auditor (Studi kasus pada Kantor Akuntan Publik di Jakarta Selatan). Proseding Seminar Nasional Akuntansi, 2(1). Retrieved from http://openjournal.unpam.ac.id/index.php/SNU/article/view/2601/2062 Hutabarat, J. F. (2015). Pengaruh Profesionalisme, Independensi, Kompetensi dan Tanggungjawab Auditor terhadap Kemampuan Auditor dalam Mendeteksi Kecurangan (Survey pada Auditor di Kap Wilayah Sumatera). Jurnal Online Mahasiswa Fakultas Ekonomi Universitas Riau, 2(2), 1–14. Karamoy, H., & Wokas, H. R. N. (2016). Pengaruh Independensi Dan Profesionalisme, Dalam Mendeteksi Fraud Pada Auditor Internal Provinsi Sulawesi Utara. Kristianti. (2017). Tipe Kepribadian, Penerimaan Perilaku Disfungsional Dan Keputusan Audit. Jurnal Economia, 13(1), 28. https://doi.org/10.21831/economia.v13i1.10906 Melati, L. (2017). Pengaruh Narsisme Klien, Audit Fee, Independensi, Skeptisme Profesional, Dan Interlock Auditor Eksternal Terhadap Audit Judgement Dalam Pendeteksian Kecurangan Laporan Keuangan (Studi Kasus Pada Kap Di Manado). Going Concern : Jurnal Riset Akuntansi, 12(2), 594–604. https://doi.org/10.32400/gc.12.2.17977.2017 Mulyadi. (1998). Auditing (5th ed.; S. T. I. E. YKPN, ed.). Salemba Empat. Nasution, H., & Fitriani. (2012). Pengaruh Beban Kerja, Pengalaman Audit dan Tipe Kepribadian Terhadap Skeptisme Profesional dan Kemampuan Auditor Dalam Mendeteksi Kecurangan. Audit, 69(2), 283–291. Nurgiyantoro, B., Gunawan, & Marzuki. (2002). Statistik Terapan. Universitas Gadjah Mada. Pangestika, R. (2014). Pengaruh Independensi Dan Efektivitas Komite Audit Terhadap Manajemen Laba (Studi Empiris pada Perusahaan Manufaktur yang Terdaftar di Bursa Efek Indonesia Tahun 2010 – 2012). Jurnal Telaah Dan Riset Akuntansi, 7(2), 131–141. Pratomo. (2017). Pengalaman Auditor Aparat Pengawas Intern Pemerintah ( Apip ) Terhadap Pendeteksian Fraud Dengan Skeptisisme Profesional Sebagai Variabel Intervening Pada Perwakilan Bpkp Provinsi. (60), 67– 83. Putri, F. P. (2015). Pengaruh Pengetahuan, Pengalaman Auditor, Kompleksitas Tugas, Locus of Control, dan Tekanan Ketaatan Terhadap Audit Judgement (Studi Kasus Pada Perwakilan BPKP Provinsi Riau). Audit, 39(5), 561–563. Rahmayani. (2014). Pengaruh Kemampuan Auditor, Skeptisme Profesional Auditor, Teknik Audit Dan Whistleblower Terhadap Efektivitas Pelaksanaan Audit Investigasi Dalam Pengungkapan Kecurangan (Studi Empiris Pada BPK dan BPKP Perwakilan Provinsi Riau). JOM FEKON, 1(4), 53 Ramadona. (2016). Pengaruh Struktur Kepemilikan Manajerial, Struktur Kepemilikan Institusional, Ukuran Perusahaan Dan Leverage Terhadap Konservatisme Akuntansi (Studi pada Perusahaan Makanan dan Minuman yang Terdaftar di Bursa Efek Indonesia Tahun 2011-2014. 3(1). Sulistyowati. (2014). Pengaruh Pengalaman, Kompetensi, Independensi dan Profesionalisme Auditor Terhadap Pendeteksian Kecurangan. Implementation Science, 39(1), 1–15. https://doi.org/10.4324/9781315853178 Sunyoto, D. (2007). Analisis Regresi dan Korelasi Bivariat. Yogyakarta: Amara Books. Terry, G. R. (2014). Dasar-Dasar Manajemen. Jakarta: Bumi Aksara. Umar, H. (2008). Metode Penelitian Untuk Skripsi dan Tesis Bisnis. PT Rajagrafindo Persada. Widiyastuti, M., & Pamudji, S. (2016). Pengaruh Kompetensi, Independensi, dan Proesionalisme Terhadap Kemampuan Auditor dalam Mendeteksi Kecurangan. Audit, 134(4), 635–646. Windasari, M., & Juliarsa, G. (2016). Pengaruh Kompetensi, Independensi, Dan Profesionalisme Auditor Internal Dalam Mencegah Kecurangan Pada Bpr Di Kabupaten Badung. E-Jurnal Akuntansi, 17(3), 1924–1952. Wiratmaja2, I. A. I. B. I. D. N., & Wiratmaja2, I. A. I. B. I. D. N. (2016). Pengaruh Pengalaman, Indepedensi, Skeptisme Profesional Auditor Pada Pendeteksian Kecurangan. E-Jurnal Akuntansi Universitas Udayana, 19(8), 2059–2067. https://doi.org/10.1016/0032-3950(77)90421-X Wulandari, S. (2014). Analisis Faktor-Faktor Yang Mempengaruhi Auditor Dalam Memberikan Opini Audit Going Concern. E-Jurnal Akuntansi, 6(3), 531–558.

ABSTRACT The objective of this research was to evaluate advanced potato clones for tuber yield, frying quality, plant vigor, and maturity, grown from minituber seeds, and to assess correlations between these traits. Eight advanced potato clones of Embrapa Potato Breeding Program (F11-09-03, F05-11-03, F54-11-06, F141-11-01, C2718-12-09, C2718-24-09, C2743-09-09, and CL308) and three commercial cultivars (Agata, Asterix and BRSIPR Bel) were evaluated. Experiments were carried out in autumn 2017, in Canoinhas-SC and Pelotas-RS. A randomized complete block design with four replicates was used. We used tuber seeds type IV (minibubers). We evaluated plant vigor, maturity, yield and number of marketable tubers, yield and number of total tubers, average tuber weight, specific gravity, and frying color. Individual and joint variance analyses revealed significant differences (p <0.05) among genotypes for all traits at both locations. The GxE (genotype x environment) interaction was significant for all traits. For the two locations together, clones F05-11-03, C2718-12-09, C2718-24-09 and the control cultivar BRSIPR Bel showed higher marketable tuber yields. The first two clones also showed tubers with high average tuber weight. Clone F54-11-06 showed the later maturity at both locations. Regarding the frying quality characteristics, only clone F141-11-01 showed a pattern comparable to that of the control cultivar Asterix. Also, clones with higher plant vigor had higher tuber yield, but late maturity. Frying quality traits were not correlated between them and among other traits.

Introduction: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), is a non-atherosclerotic, nonamyloid, hereditary cerebral disease of small vessels and capillaries caused by mutations in the NOTCH-3 gene located on chromosome 19. The presence of granular osmophilic material (GOM) deposition in the smooth muscle cells of vessel walls is the pathological hallmark of arteriopathy in CADASIL. GOM deposits in the basal lamina of smooth muscle of small vessels are pathognomonic for CADASIL. The presence of GOM in capillary blood vessels of the skin and muscle in biopsy and genetic studies (NOTCH-3 analysis) plays a key diagnostic role. Biopsy tests have high specificity (up to 100%) and low sensitivity (less than 50%). The NOTCH-3 test has been proposed as the primary diagnostic approach, allowing detection of 90% of affected individuals. CADASIL has an estimated prevalence between 2 and 5 in 100,000, and the phenotypic study demonstrates different clinical symptoms in the course of the disease within the same family. The average age of onset of clinical symptoms varies between 48.3 years in men and 52.2 years in women. Characteristic symptoms of migraine, stroke or TIA (transient ischemic attack), behavioral changes, early and progressive cognitive changes associated with leukoencephalopathy on imaging studies. The large association of symptoms often causes the diagnosis of CADASIL to be delayed. In this case, we had an association of gait ataxia within the framework of motor alterations, demonstrating the wide range of symptomatology of the pathology. This case report presents a familial course that started outside the most prevalent age group in the studies described and with an atypical presentation in an affected generation. Case reports: Case 01: woman, 68 years old, started progressively forgetting to perform household activities after the age of fifty, associated with primarily generalized myoclonic epileptic seizures, evolving rapidly within five years to walking apraxia with the use of a wheelchair and tonic-tonic epileptic seizures. bilateral clonic disorders, comprehension aphasia and bradypsychism. Relatives report previous migraine without chronic aura and REM (rapid eye movement sleep) sleep behavior disorder (RMSD). On neurological examination, severe ataxia with bilateral dysdiadochokinesia associated with bilateral hypometric index-index. Bilateral ROT 4+/4+ with bilateral Hoffman and Babinski signs. MMSS and MMII with FGM 4/5 proximal and distal. Case 02: woman, 36 years old, pastry chef, had episodes of forgetting about everyday activities of her work, progressive in the last three years (cake recipes, budget accounts, orders placed) associated with confusion for spatial location on the way home/ work, evolving to apraxia in writing letters and words and difficulty with calculations associated with monoparesis of the right lower limb for twelve months with progression to paresis of the lower limbs after six months and evolution to paresthesia of the upper limbs for three months. Associated with the condition, he has migraine without chronic aura and RMSD. The neurological examination showed Mini-Mental State Examination 22/30 (expected score of 29), list of animals in one minute: 09 animals; list of words starting with “F”: 03 words; clock test: 2/4; difficulty with calculations and digital agnosia with right/left apraxia; Upper limbs: eutrophic, FMG 4/5, bilateral distal; FMG 5/5 bilateral proximal; Lower limbs: eutrophic, bilateral FMG 4/5 distal and proximal with positive Mingazini; atypical gait with evidenced weakness in heel, toe and tandem gait; Bilateral dysdiadochokinesia with eumetric, slowed indexindex; ROT 4+/4+ in the right side with positive Hoffman and Babinski signs. MRI Brain (17/09/2020): extensive area of hypersignal on T2 and FLAIR (T2- weighted-Fluid-Attenuated Inversion Recovery) involving the periventricular white matter in all lobes without atrophic or expansive effect; Case 03: woman, 45 years old, started behavioral arrest epileptic seizures at the age of thirty-two, progressing to focal dysperceptive seizures with progression to bilateral tonic clonic seizures after eight months and multiple episodes of anterograde amnesia, presenting forgetfulness related to everyday work activities (exchanged worksheets , payments, calculation errors and budgets); associated with the condition presented migraine without chronic aura and RMSD. Genetic Test (04/06/2017): Heterozygous alteration in exon 8 of the NOTHC – 3 gene. Discussion: CADASIL presents a rare cause of cognitive decline and is often overlooked in diagnosis, except in cases of high clinical suspicion in a familial course. Access to imaging tests becomes fundamental for the diagnostic segment and the primordial genetic test for etiological elucidation and family planning, in the report described the family presentation with the same course of satellite symptoms (migraine without aura, and RMSD) associated with cognitive alteration with anticipation of age of onset are hallmarks of clinical thinking. Cases described in the literature show that the clinical symptomatology is not necessarily related to the level of brain injury observed in the imaging exam, which could be explained by personal factors and which exon is affected. The NOTCH-3 gene has 24 exons, in which the literature reports exon 4 as the most common mutation, followed by 3, 5 and 6, mainly in the Caucasian population. In an Asian population, the most affected exon is 4 and 11, which is also found in Italian descendants. The mutation in exon 8, described in the clinical case, is found in a population of Portuguese origin, being the second most common mutation in this nationality, behind the mutation in exon 4. Brain MRI studies have tried to elucidate the most affected brain regions, aiming to trace a line of evolution. Involvement of the temporal lobe, external capsule and corpus callosum are described as probable markers of CADASIL, and can be used as an aid in the diagnosis due to its specificity of 86% and sensitivity of 89%. Studies also show that the frontoparietal area has frequent findings of hyperintensity (100%), followed by the temporal lobe (83%), less frequently affecting the brainstem, occipital lobe and cerebellum. Despite the great advances in the specialized literature, the causes of the important cognitive dysfunction presented in the course of the evolution of CADASIL remain unclear. However, studies have suggested that the process of cognitive decline is more related to the loss of cortico-subcortical connections than to brain atrophy itself, with these disconnections resulting from repeated transient ischemic accidents. Science has been looking for ways to change the prognosis of CADASIL, recent studies in gene therapy and neurogenetics show the importance of thinking about this pathology as a genetic disease of great importance to change the prognosis of this pathology.