Journal articles on the topic 'Science=2018-12-09'

AbstractObjectiveThe purpose of the present meta-analysis was to evaluate the association between the inflammatory potential of diet, determined by the dietary inflammatory index (DII®) score, and depression.DesignSystematic review and meta-analysis.SettingA comprehensive literature search was conducted in PubMed, Web of Science and EMBASE databases up to August 2018. All observational studies that examined the association of the DII score with depression/depressive symptoms were included.SubjectsFour prospective cohorts and two cross-sectional studies enrolling a total of 49 584 subjects.ResultsOverall, individuals in the highest DII v. the lowest DII category had a 23 % higher risk of depression (risk ratio (RR)=1·23; 95 % CI 1·12, 1·35). When stratified by study design, the pooled RR was 1·25 (95 % CI 1·12, 1·40) for the prospective cohort studies and 1·16 (95 % CI 0·96, 1·41) for the cross-sectional studies. Gender-specific analysis showed that this association was observed in women (RR=1·25; 95 % CI 1·09, 1·42) but was not statistically significant in men (RR=1·15; 95 % CI 0·83, 1·59).ConclusionsThe meta-analysis suggests that pro-inflammatory diet estimated by a higher DII score is independently associated with an increased risk of depression, particularly in women. However, more well-designed studies are needed to evaluate whether an anti-inflammatory diet can reduce the risk of depression.

El desarrollo de las nuevas tecnologías de la información, así como el perfil de las nuevas generaciones, han incentivado a las instituciones financieras a buscar una mayor inclusión de sus productos y servicios en gran parte de la población del mundo. Debido a lo anterior, se observa un incremento en el interés de tener una sociedad con mayor cultura financiera que le permita tomar mejores decisiones en su economía particular. El creciente interés del ámbito de la educación financiera se observa también en la comunidad científica. El presente trabajo se enfoca en la búsqueda de la literatura científica relacionada a la educación financiera entre los años 1990-2018. Se utilizan técnicas bibliométricas y la base de datos científica de Web of Science como fuente de información. El objetivo es analizar la información encontrada, y visualizar la evolución del concepto, el número de publicaciones, la estructura de citas, las revistas más influyentes, los autores, universidades y países con mayor actividad en este tema. Los resultados arrojan total de 2134 artículos, se observa que la mayor producción va del año 2016 al 2018. La revista Economic of Education Review tiene el mayor número de publicaciones y citas. La Institución con más investigaciones es la National Bureau of Economic Research y finalmente se destaca a los Estados Unidos de América por su importante actividad en el área. A partir del surgimiento de nuevas variables en las estructuras financieras, la educación en este tópico seguirá presentando nuevas rutas por explorar por parte de la comunidad científica al servicio de la sociedad. Códigos JEL: G21, G28, G38, L26 Recibido: 03/07/2020. Aceptado: 21/09/2021. Publicado: 01/12/2021.

This research work was conducted to detect the prevalence of Infectious Laryngotracheitis (ILT) Virus-specific antibody in chickens from Gazipur district in Bangladesh at Department of Microbiology, Hajee Mohammad Danesh Science & Technology University, Dinajpur and Poultry Care Lab, Garzipur from January to June 2012. A total number of 232 sera sample of commercial layer chicken were collected from 17 different commercial layer farms at different ages. The layers prognosed for sampling had not been previously vaccinated against ILTV. The indirect enzyme linked immunosorbent assay (iELISA) was performed to estimate the Infectious Laryngotracheitis (ILT) Virus-specific antibody. Out of 232 samples, 189 (81.47%) samples were found to positive for Infectious Laryngotracheitis (ILT) Virus-specific antibody. In 17 different commercial farms prevalence based on age were 75%, 87.5%, 87.5%, 90%, 81.25%, 80%, 100%, 70%, 81.25%, 81.25%, 90%, 93.08%, 87.5%, 75%, 75%, 68.75% and 75% in the age limit 08, 09, 11, 12, 13, 14, 15, 16, 17, 17, 19, 21, 25, 31, 35, 44 and 51 weeks respectively and farms showed high level of ILT virus specific antibodies (IgG). This result showed that in 15 weeks of age prevalence was highest position i.e; 100%. The result of this study indicate that there were a high prevalence of Infectious Laryngotracheitis (ILT) Virus circulating at Gazipur district in Bangladesh.Asian J. Med. Biol. Res. March 2018, 4(1): 1-6

White clover plant, Trifolium repens L. one of the important forage crop, entirely depends on insects for its pollination. The research aims to study diversity and relative abundance of insect visitors of white clover and their relation with environmental variables in open ground of Bhaktapur Multiple Campus. Quadrate sampling method was used to explore diversity of insect visitors. Observations of the insects were conducted at morning (09:00 AM to 10:00 AM), noon (12:00 PM to 01:00 PM) and afternoon (3 PM to 4 PM) each day during study period. There were 3472 individuals of insect collected that belong to 20 species in three orders: Hymenoptera (69%), Lepidoptera (27%) and Diptera (4%). Number of individuals of visitors were comparatively higher at noon (1426) than in morning (1256) and lower in afternoon (790 individuals). Number of species found in morning and noon were same (20 species) whereas number of species found in evening was less (16 species). Apis cerana and Lampides boeticus are the most dominant species belonging to orders Hymenoptera and Lepidoptera respectively. The relation of diversity with environmental variables was correlated by using Multivariate analysis test. The test showed significant effect of light intensity, humidity, temperature and the latter one was the most influential factor on the composition of species. Journal of Institute of Science and TechnologyVolume 22, Issue 2, January 2018 Page: 86-91

1. Kostiuk O. M. Teoretyko-pravovi zasady normatyvnoho tlumachennia : avtoreferat dys. ... kand. yuryd. nauk: 12.00.01 «Teoriia ta istoriia derzhavy i prava; istoriia politychnykh i pravovykh uchen» Kostiuk Olha Mykolaivna; Ivano-Frankiv. un-t prava im. korolia Danyla Halytskoho. Ivano-Frankivsk, 2017. S. 3. 2. Rishennia Konstytutsiinoho Sudu Ukrainy vid 2 lystopada 2004 roku № 15-rp/2004. u spravi za konstytutsiinym podanniam Verkhovnoho Sudu Ukrainy shchodo vidpovidnosti Konstytutsii Ukrainy (konstytutsiinosti) polozhen statti 69 Kryminalnoho kodeksu Ukrainy (sprava pro pryznachennia sudom bilsh miakoho pokarannia) https://zakon. rada.gov.ua/laws/show/v015p710-04#Text 3. Rishennia YeSPL vid 28 zhovtnia 1999 roku u spravi «Brumaresku proty Rumunii», zaiava № 28342/95, § 61. 4. Danishevska V. Kliuchovi zasady ta pidkhody do vyrishennia konfliktiv tlumachennia zakoniv. Vzaiemni zdobutky Yevropeiskoi Komisii «Za demokratiiu cherez pravo» i orhaniv konstytutsiinoi yustytsii ta problemy tlumachennia u konstytutsiinomu sudochynstvi : zbirnyk materialiv i tez Mizhnarodnoi onlain-konferentsii (m. Kyiv, 25 chervnia 2020 r.). Kyiv: VAITE, 2020. S. 60. 5. Todyka Yu. M. Sposoby tlumachennia Konstytutsii i zakoniv Ukrainy Konstytutsiinym Sudom. Visnyk Akademii pravovykh nauk Ukrainy. Kharkiv: Pravo, 2001. № 2 (25). S. 51-59. https://dspace.nlu.edu.ua/ bitstream/123456789/4565/1/Toduka_51.pdf 6. Yevropeiska Komisiia «Za demokratiiu cherez pravo» Mirylo pravovladdia. Komentar. HLOSARII. Strasburh,18 bereznia 2016 roku. Doslidzhennia №711/2013 http://newjustice.org.ua/wp-content/uploads/2017/09/Rule_of_ Law_Checklist_UKR.pdf 7. Postanova Kasatsiinoi palaty Verkhovnoho Sudu vid 14 bereznia 2018 roku u spravi № 917/1503/17. 8. Selivanov A. O., Stryzhak A. A. Pytannia teorii konstytutsiinoho pravosuddia v Ukraini: aktualni pytannia suchasnoho rozvytku konstytutsiinoho pravosuddia. Kyiv : Lohos, 2010. 275 s. 9. Radchenko O. I. Ofitsiine tlumachennia zakonu v konteksti udoskonalennia natsionalnoho mekhanizmu zakhystu prav liudyny v Ukraini http://webcache.googleusercontent.com/search?q=cache:l3C1xwQGyHYJ:univd.edu.ua/ science-issue/issue/2996+&cd=9&hl=ru&ct=clnk&gl=ua 10. Postanova Kabinetu Ministriv Ukrainy vid 2 lypnia 2014 r. № 228 «Pro zatverdzhennia Polozhennia pro Ministerstvo yustytsii Ukrainy» https://zakon.rada.gov.ua/laws/show/228-2014-%D0%BF#Text 11. Shevchuk S. Holovna ideia pravosuddia – z bezlichi formalnostei zrobyty spravedlyve rishennia. «Iurydychna hazeta», 6 zhovtnia 2015 r. 12. Kostytskyi M., Kushakova-Kostytska N. Tlumachennia Konstytutsii ta zakoniv Ukrainy Konstytutsiinym Sudom Ukrainy ta inshymy orhanamy sudochynstva: spilnist ta vidminnist. Vzaiemni zdobutky Yevropeiskoi Komisii «Za demokratiiu cherez pravo» i orhaniv konstytutsiinoi yustytsii ta problemy tlumachennia u konstytutsiinomu sudochynstvi : zbirnyk materialiv i tez Mizhnarodnoi onlain-konferentsii (m. Kyiv, 25 chervnia 2020 r.). Kyiv :VAITE, 2020. S. 91-92. 13. Terletskyi D. Konstytutsiina skarha yak natsionalnyi zasib yurydychnoho zakhystu: yurydychni naslidky. URL: https://uplan.org.ua/analytics/konstytutsiina-skarha-iak-natsionalnyi-zasib-iurydychnoho-zakhystu-iurydychni-naslidky

Gout is associated with disturbed metabolic pathways which is hyperuricemia, due to the unbalanced state of purine nucleotide metabolism or excretion of uric acid by the kidney (1). Differentially targeted genes should be evaluated on their metabolic pathways and gene networking to investigate the potential biomarkers in developing the personalized medicine for gout. The study was opted to determine the differentially target genes with the regulatory mechanisms by using in silico analysis. Ten target genes were engine-searched from the published articles such as from PubMed, google scholar, ResearchGate, and Science Direct. The information from the articles were stratified according to populations in a mutual or close genetic entities from year 2012 to 2018. The ten chosen putative genes associated with gout were SLC2A9, ABCG2, SLC22A12, SLC22A11, SLC17A1, SLC17A2, SLC17A3, SLC17A4, SLC16A9, and SLC5A6 which were determined their biological mechanism and gene networking by using bioinformatic tools such as the Gene Ontology Resource, STRING, and Reactome Pathway. The significant associations of the putative genes with the biological mechanism and gene networking are determined based on the p-value and FDR value. The ten chosen putative genes showed significant association with the biological mechanisms and gene networking. The result from Gene Ontology Resource database showed high significant association between the putative genes and the biological processes, molecular functions, cellular components (p-value < 0.05) as depicted in Table 1.0. The highly significant associated biological processes were the organic anion transport (9.14E-19, 7.16E-15), anion transport (2.93E-17, 1.53E-13) and urate metabolic processes (2.98E-20, 4.67E-16) along with their respective raw p-value and FDR value. Then, the highly significant associated molecular functions were the active transmembrane transporter activity (5.04E-15, 2.47E- 11), symporter activity (1.16E-13, 1.90E-10) and secondary active transmembrane transporter activity (1.80E-14, 4.40E-11) along with their respective raw p-value and FDR value. While the highly significant associated cellular components were the plasma membrane region (7.26E-09, 4.90E-06), apical plasma membrane (4.48E-13, 9.08E- 10) and apical part of cell (1.64E-12, 1.66E-09) along with their respective raw p-value and FDR value. Next, the result from STRING database as depicted in Figure 1.0 were highly significant in which all the putative genes had networking among them, such that six out of ten putative genes had the highest gene networking among the others; SLC2A9, SLC22A11, SLC22A12, SLC16A9, ABCG2, SLC17A1, and followed by the other four genes which had less gene networking; SLC17A2, SLC17A3, SLC17A4, and SLC5A6. As for the Reactome Pathway database, the result as depiced in Table 2.0 showed high significant association between the putative genes and the pathways (p-value < 0.05). The highly significant pathways were the transport of small molecules (1.00E-08, 3.34E-07), SLC-mediated transmembrane transport (1.96E-08, 3.34E-07) and organic anion transport (8.36E-06, 9.19E-05) along with their respective raw p-value and FDR value. In conclusion, the study revealed the role of putative targeted genes in the biological mechanism in gout pathogenesis has provides insight of the potential biomarkers in developing the personalized medicine better treatment for gout patient in ensuring better patient healthcare.

Wind speed is the principal climatic element that drives the Marmaton season in West African sub region. It drives the season by conveying huge amount of dust across the Northeastern Nigeria. The presence of dust in the atmosphere brought by the Northeast trade winds during the Harmattan season plays a vital role in absorbing and scattering solar radiation. The study examines the spatial and temporal variations of wind speed in Northeastern Nigeria during the Harmattan season with the sole aim of ascertaining its variability, patterns and trends from1984 to 2014. Descriptive and statistics such as mean, standard deviation, coefficient of variation, and time series analysis with ArcGIS 10.3 was used in examine the temporal and spatial variations of wind speed from 1984–2014 in six synoptic stations of Northeastern Nigeria. The findings show that wind speed varied both temporally and spatially in the last three decades. The pattern of variations in the six synoptic stations shows rising trends within the study years. It was also found that latitude playing a crucial role in determining the speed of the wind in the study area and as the speed of the wind increases with increasing latitude. Keywords: Wind speed, Harmattan, Season, Northeast, Variation and ITD. References Adaramola,M.S.andOyewola,O. M. (2011). Wind Speed Distribution and Characteristics in Nigeria. Asian Research Publishing Network (ARPN). Journal of Engineering and Applied Sciences.ISSN 1819-6608.www.arpnjournals.com Amadi, S. O., Udo, S. O. and Ewona, I. O. (2014). Trends in Monthly Mean Minimum and Maximum Temperature Data over Nigeria for the Period 1950-2012. International Research Journal of Pure and Applied Physics, 2(4), 1-27. Ayoade, J.O. (2004). Introduction to Climatology for the Tropics.2nd ed. Spectrum Books Limitted, Spectrum House Ring Road Ibadan, Nigeria. Balarabe, M., Abdallah, K., and Nawawi, M. (2015). Long- Term Trend and Seasonal Variability of Horizontal Visibility in Nigerian Troposphere.Journal of Atmosphere 6:1462-1486; doi:10.3390/atmos6101462. Dahuwa, D., Promise, K. U., Umar, W., Bello, I. and Mohammed, R. (2018). Analysis of Wind Speed And Frequency InAzare North eastern Part of Nigeria. IOSR Journal of Applied Physics (IOSR-JAP) e-ISSN: 2278-4861.Volume 10, Issue 1 Ver. I. PP 09-17 www.iosrjournals.org DOI: 10.9790/4861-1001010917 www.iosrjournals.org Danlami, D., Gwari, M., Suleiman, S., and Bara, A. (2018). Temporal and Spatial variations of Groung Surface visibility during Harmattan Season in North-Eastern Nigeria.Ceylon Journal Science, 47(4), 337 – 346. DOI: http://doi.org/10.4038/cjs.v47i4.7551. Danlami, D. (2017). Spatio-Temporal Variations of Harmattan Season in Northeastern Nigeria.M.Sc. Dissertation (Not published) Submitted to the Department of Geography, Bayero University, Kano, Nigeria. De Longueville, F., Hountondji, Y. C., Henry, S. and Ozer, P. (2010). What do we Know about the Effects of Desert Dust on Air Quality and Human Health in West Africa compared to other regions? Journal: Science of Total Environment Fagbenle, R.L., Fasade, A.O., Amuludun A.K. andLala,P.O.( 1980). Wind power potentials of Nigeria. 12th Biennial conference of the West African Science Association, University of Ife, Nigeria. Getis, A., Getis, J., Bjelland, M. and Fellmann, J.D. (2011).Introduction to Geography. 13thed. The McGraw-Hill Companies, Inc., 1221 Avenue of the Americas, NY10020. Karabulut, M., Demirci, A. and Kora, F. (2012). Analysis of spatially distributed annual, seasonal and monthly temperatures in Istanbul from 1975 to 2006.World Applied Sciences Journal, 12(10), 1662-1675 Ojosu, J.O. and Salawu, R.I. (1990).An evaluation of wind energy potential as a power generation source in Nigeria.Solar & Wind Technology.ELSEVIER.Volume 7, Issue 6, 1990, Pages 663-673 Schwanghart, W. and Schutt, B. (2007). Meteorological causes of Harmattan dust in West Africa. Journal of Science Direct Geomorphology. Shuman, M. (2007) Evaluation of five GIS basedInterpolation techniques for estimating the Radonconcentration for unmeasured zip codes in thestate of Ohio, Master of Science Degree in Civil Engineering, University of Toledo, 28-29 Pp. Waewsak, J., Chancham, C., Landry, M. and Gagnon, Y (2011).An Analysis of Wind Speed Distribution at Thasala, Nakhon Si Thammarat, Thailand.Journal of Sustainable Energy & Environment 2 pp 51-55 Willmott, C., Robeson, S. and Philpot, W. (1985). Small- scale climate maps: A sensitivity analysisof some common assumptions associated withgrid-point interpolation and contouring. American Cartographer 12(1):5-16. Copyright (c) 2019 Geosfera Indonesia Journal and Department of Geography Education, University of Jember This work is licensed under a Creative Commons Attribution-Share A like 4.0 International License

Introduction Elotuzumab is monoclonal antibody (mAb) that specifically targets signaling lymphocytic activation molecule family member 7 (SLAMF7) that is present on myeloma cells. It fights myeloma cells by stimulating phagocytic action of NK cells and via ADCC (antibody‐dependent cell‐mediated cytotoxicity) pathway. Daratumumab is an anti-CD38 mAb with dual mechanisms of action i.e. tumoricidal and immunomodulation. The aim of this study is to review the efficacy and toxicity of elotuzumab and daratumumab based 3-drug combinations in patients (pts) with multiple myeloma (MM). Methods A systematic search of PubMed, Embase, Clinicaltrials.gov, Cochrane and Web of Science was performed for elotuzumab and daratumumab based regimen in MM patients from inception to June 12, 2019. Out of 604 studies, 08 phase II and III clinical trials based on 3-drug regimen were finalized. Results Total 2809 patients (pts) were evaluated out of 2879 enrolled pts. 856 were newly diagnosed (ND) and 1953 were relapsed/refractory (R/R). Elotuzumab (E) based 3-drug regimen were evaluated in 560 whereas daratumumab (D) based 3-drug regimen were analyzed in 889 pts. ELOQUENT-3 trial (n=117) in phase II used E + pomalidomide (P) and dexamethasone (d) (EPd) for R/R pts with ≥2 prior therapies. Median (m) progression free survival (PFS) was 10.2 months (mo) in EPd versus (vs) 4.6 mo in Pd arm [Hazard ratio (HR) 0.54 (95% CI: 0.34-0.86; p=0.008)], i.e. 46% lower risk of progression or death in EPd vs Pd arm. ORR (overall response rate) was 53% (complete response [CR] 5% + stringent CR [sCR] 3% + partial response [PR] 33% + very good partial response [VGPR] 12%) in EPd vs 26% in Pd arm (odds ratio [OR]: 3.25 (1.49-7.11). Grade (G) ≥3 adverse events (AEs) were anemia (10%), neutropenia and infections (13% each). (Dimopoulos et al. 2018). Phase II trial by Jakubowiak et al. (2016) observed 1 year (y) PFS of 39% in E-Bortezomib(B)-d vs 33% in Bd arm in 152 R/R pts (HR: 0.72; p = .09) with 28% decrease in progression or death with EBd vs Bd. ORR was 66% (4% CR+ 33% VGPR + 30% PR) vs 63%. OS (overall survival) at 1 y was 85% (EBd) and 74% (Bd) (HR:0.6). G≥3 AEs were infections (21%), thrombocytopenia and peripheral neuropathy (9% each). In phase II trial, ELd (E-Lenalidomide-d) arm yielded ORR of 88% (CR 3% + sCR 5% + PR 43% + VGPR 38%) vs 74% in Ld arm in 82 ND pts. PFS at 1 yr was 93% vs 91%. G≥3 AEs included neutropenia (18%) and leukopenia (15%). (Takezako et al. 2017). Berenson et al. (2017) in phase II trial (n=70) studied G≥3 infusion reactions (IRs) using ELd in ND and R/R pts. ORR was 70% (CR 6% + VGPR 27% + PR 37%). G3 AEs included anemia in 10% pts (no G3 IRs). ELOQUENT-2 trial randomized 646 R/R pts in phase III. PFS at 4 y is 21% vs 14% (HR: 0.71, 0.59-0.86; p= .0004), favoring ELd with 29% reduction in myeloma progression or death. With VGPR of 30%, ORR was 79% vs 66 % (ELd vs Ld) with HR: 0.77; 0.62-0.95; p = 0.0176. OS at 4 y was 50% vs 43% (HR: 0.78; 0.63-0.96). G≥3 AEs included lymphocytopenia (79%), neutropenia (36%), anemia (20%) and thrombocytopenia (21%). (Dimopoulos et al, 2018). POLLUX trial used daratumumab (D)-Ld regimen in 569 R/R patients in phase III. PFS at 3 y was 55% vs 27% (DLd vs Ld) in pts with 1-3 prior therapies. With 56% CR and 80% VGPR; ORR was 93% vs 76%. DLd arm achieved 30% minimal residual disease (MRD)-negative status compared to 5% in Ld arm (p<0.001). OS at 3-yr was 34% vs 42%. G≥3 AEs were neutropenia (55%), anemia (18%), thrombocytopenia (15%) and pneumonia (14%). (Bahlis et al. 2018). CASTOR trial in phase III (n=498) showed 18-mo PFS of 48% vs 7.9% in DBd vs Bd arm in R/R pts (HR: 0.31 (0.24-0.39); p<0.0001). ORR was 83.8% (CR 28.8%+ sCR 8.8% + VGPR 62.1%) vs 63.2% (p<0.001). DBd-treatment led to 11.6% MRD-negative status vs 2.4% in Bd-treated pts (p=0.000034). Thrombocytopenia (45.7%), anemia (15.2%) and neutropenia (13.6%) were G≥3 AEs. (Spencer et al. 2018). A Phase III trial (n=737) observed 30 mo PFS of (66 vs 52) % in ≥75 y old pts [HR 0.63 (0.44-0.92)] with DLd vs Ld arms in ND transplant ineligible pts with ORR of (90 vs 81) % (≥CR 41% + ≥VGPR 77%). MRD- negative rate was (19 vs 8) % in DLd vs Ld arms respectively. G≥3 AEs were neutropenia (60%), lymphopenia (19%), anemia (16%), pneumonia (15%) and leukopenia (12%). <75 y old showed ORR of (95 vs 82) % with 30 mo PFS of (75 vs 58) % in both arms. (Usmani et al 2019). Conclusion: Elotuzumab and daratumumab based 3-drug combinations showing great improvements in ORR, PFS and OS of ND and RR MM patients with favorable toxicity profile. Disclosures Anwer: In-Cyte: Speakers Bureau; Seattle Genetics: Membership on an entity's Board of Directors or advisory committees.

BackgroundTumor infiltrating T-cells have a prognostic benefit in many tumor types,1–8 and we recently sought to determine whether the level of T-cell infiltration into renal tumors predicts clinical outcomes. In our recent publication,9 we showed that patients with high of CD8 T-cell infiltration have improved progression free survival (PFS). Further, we found that this T-cell response is supported by TCF1+ stem-like CD8 T-cells, which reside within dense regions of closely clustered antigen presenting cells within the tumor. Interestingly, aggregations of immune cells have also been described in other tumor types and termed ‘tertiary lymphoid structures’ (TLS), which are typically defined as B-cell-dominant aggregates, containing high endothelial venules and reactive germinal centers.10–12 Together, these findings raise several important questions, which we explore here—(1) what additional cell types comprise these niches?9 and (2) how are these niches similar to or different from TLS?MethodsTumor tissue was collected from patients with renal tumors undergoing surgery at Emory University Hospital. Intraoperative tumor samples were analyzed by flow cytometry, RNA sequencing, immunofluorescence, and immunohistochemistry. Immunofluorescence data was analyzed using our custom quantitative analysis pipelines, which allows for delineation of cell type and location, cell-cell distance, and density of cellular aggregation.ResultsThe proportion of CD8 T-cells infiltration human renal tumors varied widely, consistent with our previous reports.9 TCF1+ stem-like CD8 T-cells were identifiable by both flow cytometry and immunofluorescence and resided in dense antigen presenting niches. Quantitative immunofluorescence revealed the location of aSMA+ fibroblasts within tumor tissue, in relation to antigen presenting niches, and in tumors with many infiltrating T-cells. Pathologist scored hematoxylin and eosin-stained slides were delineated TLS+ or TLS-. Quantitative immunofluorescence imaging analysis revealed the detailed composition of tumor infiltrating immune cell populations and the contrasting cellular organization in TLS as compared to in antigen presenting niches.ConclusionsAs we have shown CD8 T-cell infiltration to predict PFS in renal tumors and that antigen presenting niches containing stem-like cells maintain the anti-tumor T-cell response,9 it is critical to understand the additional cell types present in these niches and to understand how these niches relate to previously described phenomena of immune organization, such as TLS.10–12 This mechanistic understanding of the anti-tumor immune response represents an opportunity to inform development of enhanced prognostic tools and innovative therapeutic possibilities.ReferencesAzimi F, et al. Tumor-infiltrating lymphocyte grade is an independent predictor of sentinel lymph node status and survival in patients with cutaneous melanoma. J Clin Oncol 2012;30(21):2678–83. Epub 2012/06/20. doi: 10.1200/jco.2011.37.8539. PubMed PMID: 22711850.Galon J, et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 2006;313(5795):1960–4. Epub 2006/09/30. doi: 10.1126/science.1129139. PubMed PMID: 17008531.Mlecnik B, et al. Integrative analyses of colorectal cancer show immunoscore is a stronger predictor of patient survival than microsatellite instability. Immunity 2016;44(3):698–711. Epub 2016/03/18. doi: 10.1016/j.immuni.2016.02.025. PubMed PMID: 26982367.Mlecnik B, et al. Histopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction. J Clin Oncol 2011;29(6):610–8. Epub 2011/01/20. doi: 10.1200/JCO.2010.30.5425. PubMed PMID: 21245428.Pagès F, et al. Immune infiltration in human tumors: a prognostic factor that should not be ignored. Oncogene 2009;29:1093. doi: 10.1038/onc.2009.416.Peranzoni E, et al. Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti-PD-1 treatment. Proceedings of the National Academy of Sciences of the United States of America 2018;115(17):E4041–E50. Epub 2018/04/11. doi: 10.1073/pnas.1720948115. PubMed PMID: 29632196.Savas P, et al. Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis. Nat Med 2018;24(7):986–93. Epub 2018/06/27. doi: 10.1038/s41591-018-0078-7. PubMed PMID: 29942092.Tosolini M, et al. Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, th2, treg, th17) in patients with colorectal cancer. Cancer Res 2011;71(4):1263–71. Epub 2011/02/10. doi: 10.1158/0008-5472.Can-10-2907. PubMed PMID: 21303976.Jansen CS, et al. An intra-tumoral niche maintains and differentiates stem-like CD8 T cells. Nature 2019;576(7787):465–70. doi: 10.1038/s41586-019-1836-5.Dieu-Nosjean MC, et al. Tertiary lymphoid structures in cancer and beyond. Trends Immunol 2014;35(11):571–80. Epub 2014/12/03. doi: 10.1016/j.it.2014.09.006. PubMed PMID: 25443495.Goc J, et al. Characteristics of tertiary lymphoid structures in primary cancers. Oncoimmunology 2013;2(12):e26836. Epub 2014/02/06. doi: 10.4161/onci.26836. PubMed PMID: 24498556; PMCID: PMC3912008.Sautes-Fridman C, et al. Tertiary lymphoid structures in the era of cancer immunotherapy. Nature reviews Cancer 2019;19(6):307–25. Epub 2019/05/17. doi: 10.1038/s41568-019-0144-6. PubMed PMID: 31092904.Ethics ApprovalSamples are collected under an approved IRB protocol (The Urological Satellite Specimen Bank at Emory University, IRB00055316). All patients provided informed consent.ConsentSamples are collected under an approved IRB protocol (The Urological Satellite Specimen Bank at Emory University, IRB00055316). All patients provided informed consent.

Resumen: El objetivo de la presente investigación es explorar la estructura y el contenido de una red de usuarios de abuso sexual basado en imágenes en Twitter. Para ello se analizaron los perfiles de Twitter que contienen la palabra "Quemón o “Nudes” utilizando análisis de redes, técnicas de procesamiento natural del lenguaje. Entre 2017 y 2018 hubo una comunidad de abuso sexual basado en imágenes en Twitter. Al menos 329 usuarios se dedicaron y se auto describieron como cuentas sexualmente explícitas, vengativas, y en donde contenido sexual no consensual podía ser compartido de forma anónima. Ya con seguidores, la red comprende a más de 130,000 personas. Esta es una estimación conservadora, más cuentas podrían utilizar diferentes palabras clave, no tener ninguna descripción, o formar parte de comunidades privadas. Estos resultados sugieren que los consumidores de contenido de abuso sexual basado en imágenes son los principales responsables de su propagación. Abstract: This study aimed to explore the structure and content of an image-based sexual abuse user network on Twitter. For this purpose, Twitter profiles containing the word “Quemones” or "Nudes" were analyzed using network analysis, natural language processing techniques. Between 2017 and 2018 there was a community of image-based sexual abuse on Twitter. At least 329 users engaged in and self- described themselves as sexually explicit, vindictive accounts, and where nonconsensual sexual content could be shared anonymously. Already with followers, the network comprises more than 130,000 people. This is a conservative estimate; more accounts could use different keywords, have no description, or be part of private communities. These results suggest that consumers of image-based sexual abuse content are primarily responsible for its spread. Fuentes de Consulta: Allen, W. D. (2007). The Reporting and Underreporting of Rape. 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The aim of this study was to describe the international academic mobility experienced by the Fishing Engineering students in other countries. The data was collected through an electronic semi-structured questionnaire hosted on an electronic platform by Google. A total of nine students answered the questionnaire, in which they chose countries such as France, Spain, Ireland, Canada, the United States and Australia to study abroad in. The student’s satisfaction with the Science without Borders Program (SwB) was extremely positive, where all the interviewees stated that they had learned the language from the hosting country. In relation to the negative aspects, 67% of the interviewees pointed out that they struggled to understand the language in the beginning of the academic mobility, and 78% of the students said that they missed their families during the student mobility period. In conclusion, the academic mobility performed by students from the Fishing Engineering course was rated as excellent, and as a unique and an enriching opportunity, both in professional and personal aspects.ResumoO trabalho teve como objetivo discutir sobre a mobilidade acadêmica vivenciada por estudantes de Engenharia de Pesca em outros países. A coleta de dados foi feita através de um questionário eletrônico semiestruturado, hospedado em uma plataforma eletrônica de formulários da Google. Um total de nove discentes respondeu ao questionário, realizando a mobilidade na França, Espanha, Irlanda, Canadá, Estados Unidos e Austrália. A satisfação dos estudantes com o Programa Ciência sem Fronteiras (CsF) foi positiva, todos os entrevistados afirmaram terem aprendido o idioma do país que escolheram. Em relação aos aspectos negativos, 67% dos entrevistados apontaram que tiveram dificuldades no entendimento do idioma do país no início da mobilidade acadêmica e 78% sentiram saudade da família no período da mobilidade. Concluindo, a mobilidade acadêmica realizada por discentes do Curso de Engenharia de Pesca foi classificada como excelente, sendo uma experiência única e enriquecedora tanto pelo lado profissional, quanto pessoal.Palavras-chave: Educação, Aprendizado, Internacionalização, Programa Ciência sem Fronteiras.Keywords: Education, Learning, Internationalization.ReferencesALTBACH, P. G. Comparative Higher Education: Knowledge, the University, and Development. Hong Kong: University of Hong Kong, p. 240, 1998.ANDRADE, B. P. S. O “Ciência sem Fronteiras” pelo olhar da comunidade acadêmica: O caso da Unifal-mg e da Unifei. 2018. 185f. Dissertação (Mestrado em Divulgação Científica e Cultural). 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Introduction Multiple myeloma afflicted cells express signaling lymphocytic activation molecule family member 7 (SLAMF7). Elotuzumab; a monoclonal antibody (mAb), targets SLAMF7 and fights myeloma cells by stimulating phagocytic action of natural killer (NK) cells and via antibody‐dependent cell‐mediated cytotoxicity (ADCC) pathway. This study focuses on the clinical utility and tolerability of elotuzumab based combinations in patients (pts) with multiple myeloma (MM). Methods Literature search of PubMed, Embase, Clinicaltrials.gov, Cochrane and Web of Science was performed from inception to June 12, 2019 for elotuzumab based combinations in MM patients. Total of 06 phase II and phase III clinical trials were selected for systematic review out of 292 studies. Results Elotuzumab (E) based combinations were evaluated in 1075 patients (pts) out of 1115 enrolled pts. 119 were newly diagnosed (ND) and 956 were relapsed/refractory (RR) patients. Newly Diagnosed MM patients: Takezako et al. 2017; in phase II trial, showed overall response rate (ORR) of 88% (complete response [CR] 3% + stringent CR [sCR] 5% + partial response [PR] 43% + very good partial response [VGPR] 38%) with ELd (E-Lenalidomide-dexamethasone) arm vs 74% in Ld arm in 82 ND pts. Progression free survival (PFS) at 1 year (y) was 93% versus (vs) 91%. Grade (G) ≥3 adverse events (AEs) included neutropenia (18%) and leukopenia (15%). Relapsed/Refractory MM patients: E-Bortezomib(B)-d arm in a phase II trial by Jakubowiak et al. (2016) showed 1 y PFS of 39% vs 33% in Bd arm in 152 RR pts (Hazard ratio [HR]: 0.72; p = .09) with 28% decrease in progression or death with EBd vs Bd arm. Objective response rate (ORR) was 66% (4% CR+ 33% VGPR + 30% PR) vs 63%. OS (overall survival) at 1 y was 85% (EBd) and 74% (Bd) (HR: 0.6). G≥3 AEs were infections (21%), thrombocytopenia and peripheral neuropathy (9% each). Mateos et al. (2016) in phase II trial (n=40) evaluated E-T (thalidomide)-d with or without Cy (cyclophosphamide) in heavily pre-treated RR pts. Pts received Cy if they failed to achieve PR by the 5th cycle or because of progressive disease (PD). Responses were better with ETd vs ETdCy. ORR was 38% (95% CI: 23-54) in ETd vs 9% (95% CI: 0-41) in ETdCy. Entire study yielded median PFS (mPFS) of 3.9 months (mo) (95% CI: 2.79%-9.43%) with 1-y PFS of 30% and mOS of 16.3 mo (95% Cl: 8.87%-25.66%) with 1-y survival rate of 63%. G≥3 AEs were lymphopenia (50%), anemia (20%), leucopenia (20%) and respiratory tract infections (RTI) (8%). Dimopoulos et al. 2018 studied E + pomalidomide (P) + d (EPd) for RR pts with ≥2 prior therapies in phase II ELOQUENT-3 trial (n=117). EPd arm yielded mPFS of 10.2 mo vs 4.6 mo in Pd arm [HR: 0.54 (95% CI: 0.34-0.86; p=0.008)], i.e. 46% lower risk of progression or death in EPd vs Pd arm. ORR was 53% (CR 5% + sCR 3% + PR 33% + VGPR 12%) in EPd vs 26% in Pd arm (odds ratio [OR]: 3.25 (1.49-7.11). G≥3 AEs were anemia (10%), neutropenia and infections (13% each). Phase III ELOQUENT-2 trial randomized 646 RR pts. PFS at 4 y was 21% vs 14% (HR: 0.71, 95% CI: 0.59-0.86; p= .0004), favoring ELd with 29% reduction in myeloma progression or death. With VGPR of 30%, ORR was 79% vs 66 % (ELd vs Ld) with HR: 0.77; 95% CI: 0.62-0.95; p = 0.0176. OS at 4 y was 50% vs 43% (HR: 0.78; 95% CI: 0.63-0.96). G≥3 AEs included lymphocytopenia (79%), neutropenia (36%), anemia (20%) and thrombocytopenia (21%). (Dimopoulos et al, 2018). Newly Diagnosed & Relapsed/Refractory MM patients: Phase II trial (n=70) by Berenson et al. (2017) studied G≥3 infusion reactions (IRs) using ELd in ND (n=37) and RR (n=33) pts. ORR was 78% (95% CI: 62%‐90%) for ND and 61% (95% CI: 42%‐77%) for RR pts. Other response rates were CR 6%, VGPR 27% and PR 37% in all patients. G3 AEs included anemia in 10% pts (no G3 IRs were seen). Conclusion: Elotuzumab based combinations showing promising outcomes in terms of ORR, PFS and OS for ND and RR MM patients with tolerable toxicity profile. More clinical studies with elotuzumab in unique and newer combinations need to be tested in prospective trials. Disclosures Anwer: In-Cyte: Speakers Bureau; Seattle Genetics: Membership on an entity's Board of Directors or advisory committees.

ABSTRAK Penelitian ini bertujuan untuk mengetahui adanya pengaruh value for money perception dan emotional brand attachment terhadap niat membeli kosmetik halal khususnya produk Innisfree. Selain itu, untuk meningkatkan literasi tentang value for money perception dan emotional brand attachment terhadap buying intention. Pendekatan kuantitatif digunakan dalam metodologi penelitian ini dengan Path Analysis sebagai teknik analisis data. Pengumpulan data dengan menyebarkan kuesioner skala Likert berskala lima secara online. Responden dalam penelitian ini adalah 100 mahasiswi diberbagai universitas di Surabaya yang belum pernah menggunakan produk Innisfree. Hasil dari riset menunjukkan bahwa hubungan antar variabel value for money perception terhadap buying intention, value for money perception terhadap emotional brand attachment, dan emotional brand attachment terhadap buying intention ketiganya memiliki pengaruh secara signifikan positif. Kata Kunci: Value for Money Perception, Emotional Brand Attachment, Buying Intention, Kosmetik Halal. ABSTRACT This study aims to determine the effect of value for money perception and emotional brand attachment on the intention to buy halal cosmetics, especially Innisfree products. In addition, to increase literacy about value for money perception and emotional brand attachment to buying intention. A quantitative approach is used in this research methodology with Path Analysis as a data analysis technique. Collecting data by distributing a five-scale Likert scale questionnaire online. Respondents in this study were 100 female students in various universities in Surabaya who had never used Innisfree products. The results of the research show that the relationship between the variable value for money perception on buying intention, value for money perception on emotional brand attachment, and emotional brand attachment on buying intention, all three have a significant positive effect. 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Purpose The purpose of this paper is to create ways of improving the alignment of strategy formulation and implementation in Brazil’s higher education institutions (HEIs). Design/methodology/approach Evolution of scenarios and models through a 12-step process to assist strategy formulation and implementation for managerial/social activity in Brazil’s HEIs. Simple set theory was used as a backbone to assist scenario building. Two models were created. First, focused on an autopoietic model relating to Brazil’s HEIs. The second embedded the autopoietic model in a limited number of forces in Brazil that influence the HEIs but lie beyond their control. The process was corroborated by survey methods using respondents from Brazil and elsewhere. Findings In total, 22 respondents from within and outside Brazil confirmed the content of the scenarios while a small sample from within Brazil’s HEIs confirmed their usefulness in assisting strategy formulation and implementation. Practical implications Further experience in using the autopoietic model is needed to widen its corroboration beyond experience in this study. Originality/value Confirmation of a 12-step scenario-based process for strategy formulation and implementation and corroboration of its usefulness through a limited sample of respondents.

ABSTRAKPangsa pasar perbankan Syariah di Indonesia masih rendah. Penelitian ini bertujuan untuk mengetahui pengaruh variabel pengetahuan, motivasi, dan marketing terhadap keengganan minat UMKM di sekitar wisata religi di Madura untuk mempunyai produk pembiayaan di bank syariah. Jenis data pada penelitian merupakan data primer yang didapatkan melalui penyebaran kuesioner pada pemiliki UMKM pada kawasan wisata religi di Madura dan tidak memiliki produk pembiayaan di bank syariah. Regresi liniear berganda digunakan untuk mengolah data penelitian ini. Hasil dari penelitian ini yaitu pengetahuan dan motivasi berpengaruh signifikan terhadap keengganan minat UMKM mengambil pembiayaan pada bank syariah. Variabel marketing tidak berpengaruh signifikan terhadap keengganan minat mengambil pembiayaan pada bank syariah. Berdasarkan hasil tersebut maka perlu dilakukan penelitian lebih lanjut untuk mengidentifikasi faktor lain yang akan mendorong minat UMKM untuk mengambil pembiyaan pada bank syariah.Kata Kunci: Bank syariah, Pariwisata Syariah, Keengganan Minat, UMKM. ABSTRACTThe market share of Islamic banking in Indonesia is still low. his study aims to determine the effect of knowledge, motivation, and marketing variables on the reluctance of MSME interest in religious tourism in Madura to have financing products in Islamic banks. The type of data in this study is primary data obtained through distributing questionnaires to MSME owners in religious tourism areas in Madura and not having financing products at Islamic banks. Multiple linear regression was used to process the research data. The results of this study are knowledge and motivation have a significant effect on the reluctance of MSMEs to take financing at Islamic banks. 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e4912046This scoping exploratory review was aimed at analyzing the challenges that the so-called post-truth world represents for teaching in Ibero-Latin American higher education. With the increased access to online information media and social networks, netizens are increasingly exposed and may be more vulnerable to false or misleading information that seeks to generate action from emotions rather than reason (GOSWAMI, 2017, Chronicle of Higher Education). The reference search was carried out in the databases of SciELO and La Referencia, from which 26 titles out of 196 were selected. Combinations of terms such as social media, post-truth, fake news, fact-checking, education, higher education, university, teaching, critical thinking, and freedom of expression were used, with the Boolean “Y” connector. The analysis of the references resulted in six thematic categories: main concepts; realms of fake news; news verification initiatives and methods; theoretical analysis and its relationship with education; studies on the factors, perception and credibility of fake news; and addressing misinformation in higher education. The discussion presents the draft of a proposed pedagogical model to be used in higher education and to address misinformation. Includes: critical thinking habits, democratic dialogue, intellectual skepticism, research skills, use of reliable sources of information, and analysis from multiple perspectives.ResumoEsta revisão exploratória de escopo teve como objetivo analisar os desafios que o chamado mundo pós-verdade representa para o ensino na educação superior ibero-americana. Com o aumento do acesso às mídias de informação online e redes sociais, os internautas estão cada vez mais expostos e podem ficar mais vulneráveis a informações falsas ou enganosas que buscam gerar ações a partir de emoções ao invés da razão (GOSWAMI, 2017, Chronicle of Higher Education). A busca das referências foi realizada nas bases de dados SciELO e La Referencia, das quais foram selecionados 26 títulos em 196. Combinações de termos como mídia social, pós-verdade, notícias falsas, checagem de fatos, educação, ensino superior, universidade, ensino, pensamento crítico e liberdade de expressão foram usadas, com o conector booleano “Y”. A análise das referências resultou em seis categorias temáticas: conceitos principais; escopos de notícias falsas; iniciativas e métodos de verificação de notícias; análise teórica e sua relação com a educação; estudos sobre os fatores, percepção e credibilidade das notícias falsas; e aproximação a desinformação no ensino superior. A discussão apresenta o esboço de uma proposta de modelo pedagógico para ser usado no ensino superior e para lidar com a desinformação. Inclui: hábitos de pensamento crítico, diálogo democrático, ceticismo intelectual, habilidades de pesquisa, uso de fontes confiáveis de informação e análise de múltiplas perspectivas.ResumenEsta revisión exploratoria de alcance tuvo como fin analizar los desafíos que para la enseñanza en la educación superior iberoamericana representa lo que se denomina el mundo posfactual (post-truth). Con el incrementado acceso a medios de información en línea y las redes sociales, los cibernautas están cada vez más expuestos y pueden ser más vulnerables a información falsa o engañosa que busca generar acción a partir de las emociones antes que la razón (GOSWAMI, 2017, Chronicle of Higher Education). La búsqueda de referencias se efectuó en las bases de datos de SciELO y La Referencia, de la cual se seleccionaron 26 títulos de 196. Se usaron combinaciones de términos como redes sociales, posverdad, noticias falsas, verificación de hechos, educación, educación superior, universidad, enseñanza, pensamiento crítico y libertad de expresión, con el conector booleano “Y”. El análisis de las referencias dio como resultado seis categorías temáticas: conceptos principales; ámbitos de las noticias falsas; iniciativas y métodos de verificación de noticias; análisis teóricos y su relación con la educación; estudios sobre factores, percepción y credibilidad de las noticias falsas; y abordaje de la desinformación en la educación superior. En la discusión se presenta el borrador de un modelo pedagógico propuesto para ser utilizado en la educación superior y abordar la desinformación. 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UNESCO Forum Occasional Paper Series, n. 13/S, 2003.VIZOSO GARCÍA, Ángel Antonio; VÁZQUEZ HERRERO, Jorge. Plataformas de fact-checking en español. Características, organización y método. Communication Society, v. 32v, n. 1, 2019, p. 127-144. Disponível em: https://doi.org/10.15581/003.32.1.127-144. Acesso em: 14 de outubro de 2020.WHITTEMORE, Robin; CHAO, Ariana; JANG, Myoungock; et.al. Methods for knowledge synthesis. Heart Lung, v. 43, 2014, p. 453-461. Disponível em: http://dx.doi.org/10.1016/j.hrtlng.2014.05.014. Acesso em: 3 de dezembro de 2020.WORLD BANK. Lifelong learning in the global knowledge economy: Challenges for developing countries. Washington, DC: The International Bank for Reconstruction and Development, 2003. Disponível em: http://siteresources.worldbank.org/INTLL/Resources/Lifelong-Learning-in-the-Global-Knowledge-Economy/lifelonglearning_GKE.pdf. Acesso em: 2 de outubro de 2020.

ABSTRAK Kemisikinan merupakan suatu permasalahan yang harus ditemukan cara mengentaskannya. Islam agama yang sempurna telah memberikan solusi melalui instrument zakat, infak, dan sedekah. Tujuan dari penelitian ini adalah untuk menilai dampak zakat, infak, sedekah di LAZNAS LMI (Lembaga Manajemen Infaq) dengan Pendekatan CIBEST. Metode penelitian yang digunakan adalah kuantitatif dengan uji beda antara kondisi material dan spiritual mustahik sebelum dibantu dengan setelah disalurkan dana ZIS. Hasil analisis dari 355 penerima manfaat menunjukkan bahwa pada kuadran I, penerima manfaat yang dikategorikan sejahtera bertambah 28% sesudah dibantu. Pada kuadran II, penerima manfaat yang dikategorikan miskin secara material menurun sebesar 27,7%. Selain itu pada kuadran IV penerima manfaat yang dikategorikan miskin secara absolut, juga ikut menurun sebesar 0,3%. Hasil Uji Beda juga menunjukan ada perbedaan indeks spiritual maupun indeks material penerima manfaat antar sebelum dan sesudah pemberian dana ZIS dibuktikan dengan Uji Beda Wilcoxon untuk indeks material value, dan Uji T berpasangan untuk indeks spiritual value.. Dengan adanya hasil penilaian kaji dampak ini diharapkan dampak dari bantuan yang diberikan bisa terukur dan juga menjadi bahan evaluasi serta perencanaan untuk program-program yang akan datang. Implikasi temuan penelitian ini dapat memberikan refrensi terkait manfaat zakat, infak, sedekah dalam membantu mengetaskan kemiskinan yang dilakukan oleh lembaga amil zakat nasional. Secara praktik, Lembaga Manajemen Infaq perlu memberikan perhatian khusus kepada mustahik yang berada di kategori miskin absolut, dengan memberikan intervensi ekonomi dan pembinaan secara spiritual. Kata Kunci: Kaji Dampak, ZIS, Kemiskinan, CIBEST, Lemabga Amil Zakat, Lembaga Manajemen Infaq. ABSTRACT Poverty is a problem that must find a way to eradicate. Islam, the perfect religion, has provided a solution through the instruments of zakat, infaq, and shadaqah. The purpose of this study was to assess the impact of Zakat, Sedekah, and Infaq in Lembaga Manajemen Infaq with the CIBEST Approach. The method used is quantitative by distributing questionnaires and testing the difference between the material and spiritual conditions of the mustahik before being assisted with after the ZIS funds are distributed. The results of the analysis of 355 beneficiaries showed that in quadrant I, beneficiaries categorized as prosperous increased by 28% after being assisted. In quadrant II, beneficiaries categorized as materially poor decreased by 27.7%. In addition, in quadrant IV, beneficiaries who are categorized as absolute poor also decreased by 0.3%. The results of the Difference Test also show that there are differences in the spiritual index and material index of beneficiaries between before and after the provision of ZIS funds, as evidenced by the Wilcoxon Difference Test for the material value index, and the paired T-test for the spiritual value index. The assistance provided can be measured and can also be used as material for evaluation and planning for future programs. The implications of the findings of this study can provide a reference regarding the benefits of zakat, shadaqah, and infaq in helping to alleviate poverty carried out by the national amil zakat institution. In practice, Amil Zakat Organization needs to pay special attention to mustahik who are in the absolute poor category, by providing economic intervention and spiritual guidance. Keywords: Assessment of Impact, ZIS, Poverty, CIBEST, Amil Zakat Organization, Lembaga Manajemen Infaq. DAFTAR PUSTAKA Ahmed, B. O., Johari, F., & Wahab, K. A. (2017). Identifying the poor and the needy among the beneficiaries of zakat Need for a zakat-based poverty threshold in Nigeria. International Journal of Social Economics, 44(4), 446–458. https://doi.org/10.1108/IJSE-09-2015-0234 Amalia, & Mahalli, K. (2012). Analisis peran zakat dalam mengurangi kemiskinan: Studi kasus dompet dhuafa republika. Jurnal Ekonomi dan Keuangan. Andam, A. C., & Osman, A. Z. (2019). Determinants of intention to give zakat on employment income: Experience from Marawi City, Philippines. Journal of Islamic Accounting and Business Research, 10(4), 528–545. https://doi.org/10.1108/JIABR-08-2016-0097 Ashar, M. A., & Nafik, M. (2019). Implementasi metode CIBEST (Center of Islamic business and economic studies) dalam mengukur peran zakat produktif terhadap pemberdayaan mustahiq di lembaga yayasan dana sosial al-falah (ydsf) Surabaya. Jurnal Ekonomi Syariah Teori dan Terapan, 6(5). 1057-1071. https://doi.org/10.20473/vol6iss20195pp1057-1071 Asian Development Bank. (2021). Daftar negara dengan penduduk hidup di bawah garis kemiskinan terbanyak di Asia Tenggara. Retrieved from https://databoks.katadata.co.id/datapublish/2021/11/19/daftar-negara-dengan-penduduk-hidup-di-bawah-garis-kemiskinan-terbanyak-di-asia-tenggara Asmalia, S., Kasri, R. A., & Ahsan, A. (2018). Exploring the potential of zakah for supporting realization of sustainable development Goals (SDGs) in Indonesia. International Journal of Zakat, 3(4), 51–69. https://doi.org/10.37706/IJAZ.V3I4.106 Ayuniyyah, Q., Pramanik, A. H., Md Saad, N., & Ariffin, M. I. (2022). The impact of zakat in poverty alleviation and income inequality reduction from the perspective of gender in West Java, Indonesia. International Journal of Islamic and Middle Eastern Finance and Management. Vol. ahead-of-print No. ahead-of-print. https://doi.org/10.1108/IMEFM-08-2020-0403 Ayyubi, S. el, & Saputri, H. E. (2018). Analysis of the impact of zakat, infak, and sadaqah distribution on poverty alleviation based on the CIBEST model (Case study: Jogokariyan baitul maal mosque, Yogyakarta). In International Journal of Zakat, 3(2), 85-97. https://doi.org/10.37706/ijaz.v3i2.80 Beik, I. S., & Arsyianti, L. D. (2015). Construction of CIBEST model as measurement of poverty and welfare indices from Islamic perspective. Al-Iqtishad: Jurnal Ilmu Ekonomi Syariah, 7(1), 87–104. https://doi.org/10.15408/AIQ.V7I1.1361 Beik, I. S., & Arsyianti, L. D. (2016). Measuring zakat impact on poverty and welfare using Cibest model. Journal of Islamic Monetary Economics and Finance, 1(2), 141–160. https://doi.org/10.21098/JIMF.V1I2.524 Beik, I. S., & Arsyianti, L. D. (2017). Ekonomi pembangunan syariah. Surabaya: Rajagrafindo Persada. BPS. (2022). Persentase penduduk miskin September 2021 turun menjadi 9,71 persen. Retrieved from https://www.bps.go.id/pressrelease/2022/01/17/1929/persentase-penduduk-miskin-september-2021-turun-menjadi-9-71-persen.html Efendi, M. S., & Fathurrohman, M. S. (2021). Dampak zakat terhadap kesejahteraan material dan spiritual mustahik (Studi kasus baznas microfinance desa sawojajar). Jurnal Ekonomi Syariah Teori dan Terapan, 8(6), 686-695. https://doi.org/10.20473/VOL8ISS20216PP686-695 Ghahari, S., Khademolreza, N., Ghasemnezhad, S., Babagholzadeh, H., & Ghayoomi, R. (2018). Comparison of anxiety and depression in victims of spousal abused and non-abused women in primary health care (PHC) in Babol-Iran. UCT Journal of Social Science and Humanities Research, 6(2), 14-18. https://doi.org/10.24200/jsshr.vol6iss02pp14-18 Halimatussakdiyah, & Nurlaily. (2021). Analisis pendayagunaan zakat produktif dalam mengurangi kemiskinan berdasarkan model Cibest (Studi kasus badan amil zakat nasional Prov Sumut). At-Tawassuth: Jurnal Ekonomi Islam, 1(Januari –Juni 2021), 12–25. Handayani, R. (2020). Model Cibest terhadap pengelolaan zakat produktif untuk mengukur kesejahteraan mustahik (Studi kasus Lazisnu Kota Metro). Skripsi tidak dipublikasikan. Lampung: IAIN Metro. Hayakawa, H., & Venieris, Y. P. (2019). Duality in human capital accumulation and inequality in income distribution. Eurasian Economic Review, 9(3), 285–310. https://doi.org/10.1007/S40822-018-0110-8 Indriastuti, H. (2019). Entrepreneurial innovativeness, relational capabilities, and value co-creation to enhance marketing performance. Humanities & Social Sciences Reviews, 7(3), 181–188. https://doi.org/10.18510/hssr.2019.7328 Istikoma. (2017). Asesmen kesejahteraan model Cibest (Centre of Islamic Business and Economic Studies): Studi pada nelayan di Kecamatan Kandanghaur Kabupaten Indramayu. Skripsi tidak dipublikasikan. Bandung: Universitas Pendidikan Indonesia. Kailani, N., & Slama, M. (2019). Accelerating Islamic charities in Indonesia: Zakat, sedekah and the immediacy of social media. South East Asia Research, 28(1), 70–86. https://doi.org/10.1080/0967828X.2019.1691939 Kasri, R. A. (2013). Giving behaviors in Indonesia: Motives and marketing implications for Islamic charities. Journal of Islamic Marketing, 4(3), 306–324. https://doi.org/10.1108/JIMA-05-2011-0044 Kasri, R. A., & Ramli, U. H. (2019). Why do Indonesian muslims donate through mosques?: A theory of planned behaviour approach. International Journal of Islamic and Middle Eastern Finance and Management, 12(5), 663–679. https://doi.org/10.1108/IMEFM-11-2018-0399 Kementrian Agama Republik Indonesia. (2019). Al-Quran dan terjemahannya. Jakarta: Kemenag RI. Kurbanov, R. A., Afad Oglu Gurbanov, R., Belyalova, A. M., Maksimova, E. v, Leonteva, I. A., & Sharonov, I. A. (2017). Practical advice for teaching of university students the mechanisms of self-government of safe behavior. Electronic Journal of Mathematics Education, 12(1), 35-42. https://doi.org/10.29333/iejme/596 Mulyani, E. F. (2018). Analisis dampak pendistribusian dana zakat terhadap tingkat kemiskinan mustahik dengan menggunakan model Cibest (Studi kasus: LAZ dompet dhuafa daerah istimewa Yogyakarta). Skripsi tidak dipublikasikan. Yogyakarta: UIN Sunan Kalijaga. Nisa, N. I. (2022). Penerapan model CIBEST dalam pengentasan kemiskinan di Indonesia. Retrieved from https://kumparan.com/naylazzatnsa/penerapan-model-cibest-dalam-pengentasan-kemiskinan-di-indonesia-1xkNF2L43tu/full Obaidullah, M. (2008). Introduction to Islamic microfinance. India: IBF Net (P) Limited. Owoyemi, M. Y. (2020). Zakat management: The crisis of confidence in zakat agencies and the legality of giving zakat directly to the poor. Journal of Islamic Accounting and Business Research, 11(2), 498–510. https://doi.org/10.1108/JIABR-07-2017-0097 Pistrui, D., & Fahed-Sreih, J. (2010). Islam, entrepreneurship and business values in the Middle East. International Journal of Entrepreneurship and Innovation Management, 12(1), 107–118. https://doi.org/10.1504/IJEIM.2010.033170 Puskas BAZNAS. (2016). Kaji dampak penyaluran zakat baznas terhadap kesejahteraan mustahik tahun 2016. Jakarta: Puskas BAZNAS. Putri, O. R. (2020). Hubungan antara spiritualitas dengan kebermaknaan hidup pada remaja di panti asuhan budi mulya sukarame Bandar Lampung. Skripsi tidak dipublikasikan. Lampung: UIN Raden Intan. Rahmat, R. S., & Nurzaman, M. S. (2019). Assesment of zakat distribution: A case study on zakat community development in Bringinsari village, Sukorejo district, Kendal. International Journal of Islamic and Middle Eastern Finance and Management, 12(5), 743–766. https://doi.org/10.1108/IMEFM-12-2018-0412 Reza Dasangga, D. G., & Cahyono, E. F. (2020). Analisis peran zakat terhadap pengentasan kemiskinan dengan model Cibest (Studi kasus rumah gemilang Indonesia kampus Surabaya. Jurnal Ekonomi Syariah Teori dan Terapan, 7(6), 1060-1073. https://doi.org/10.20473/vol7iss20206pp1060-1073 Rijal, K., Zainuri, A., & Azwari, P. C. (2020). Impact analysis of the zakat, infaq and shadaqah funds distribution to the poverty level of mustahik by using Cibest method Indonesia. Fikri: Jurnal Kajian Agama,Sosial dan Budaya, 5(1), 145-158. https://doi.org/10.25217/jf.v5i1.982 Rozalinda. (2014). Ekonomi Islam: Teori dan aplikasinya pada aktivitas ekonomi. Jakarta: Rajagrafindo. Saad, R. A. J., Farouk, A. U., & Abdul Kadir, D. (2020). Business zakat compliance behavioral intention in a developing country. Journal of Islamic Accounting and Business Research, 11(2), 511–530. https://doi.org/10.1108/JIABR-03-2018-0036 Saad, R. A. J., & Haniffa, R. (2014). Determinants of (Islamic tax) compliance behavior. Journal of Islamic Accounting and Business Research, 5(2), 182–193. https://doi.org/10.1108/JIABR-10-2012-0068 Salam, A., & Nisa, R. (2021). Analisis pengaruh pendistribusian dana zakat terhadap mustahik ditinjau dengan menggunakan metode CIBEST. Jurnal Ekonomi Syariah Indonesia, 9(1), 67–73. https://doi.org/10.21927/jesi.2021.11(1).67-73 Sanrego, & Taufik. (2016). Fiqih tamkin (Fiqih pemberdayaan). Jakarta: QisthiPress. Sudarmanto, E., Revida, E., Zaman, N., Simarmata, M. M. T., Purba, S., Syafrizal, S., Bachtiar, E., Faried, A. I., Nasrullah, N., Marzuki, I., Hastuti, P., Jamaludin, J., Kurniawan, I., Mastutie, F., Susilawaty, A. (2020). Konsep Dasar Pengabdian Kepada Masyarakat: Pembangunan dan Pemberdayaan. Medan: Yayasan Kita Menulis. Sugiyono. (2015). Metode penelitian pendidikan (Pendekatan kuantitatif, kualitatif, dan R&D). Bandung: CV. Alfabeta. Suharto, E. (2005). Membangun masyarakat memberdayakan rakyat kajian strategis pembangunan kesejahteraan sosial dan pekerja sosial. Bandung: PT. Revika Aditama. Sumantri, R., Iswati, S., & Mufrodi, A. (2019). The effectiveness of distribution of zakat funds on ZDC South Sumatra. Opción, Año 35(20), 1572–1588. Widyaningsih, N., Hafidhuddin, D., & Beik, I. S. (2016). Studi dampak zakat di Sulawesi Selatan dengan model CIBEST. Jurnal Ekonomi Islam Republika, 28. Retrieved from https://fem.ipb.ac.id/d/iqtishodia/2016/Iqtishodia_20160128.pdf Yacoub, Y. (2012). Pengaruh tingkat pengangguran terhadap tingkat kemiskinan kabupaten/kota di Provinsi Kalimantan Barat. Jurnal Eksos, 8(3), 176-185.

ABSTRAK Kemisikinan merupakan suatu permasalahan yang harus ditemukan cara mengentaskannya. Islam agama yang sempurna telah memberikan solusi melalui instrument zakat, infak, dan sedekah. Tujuan dari penelitian ini adalah untuk menilai dampak zakat, infak, sedekah di LAZNAS LMI (Lembaga Manajemen Infaq) dengan Pendekatan CIBEST. Metode penelitian yang digunakan adalah kuantitatif dengan uji beda antara kondisi material dan spiritual mustahik sebelum dibantu dengan setelah disalurkan dana ZIS. Hasil analisis dari 355 penerima manfaat menunjukkan bahwa pada kuadran I, penerima manfaat yang dikategorikan sejahtera bertambah 28% sesudah dibantu. Pada kuadran II, penerima manfaat yang dikategorikan miskin secara material menurun sebesar 27,7%. Selain itu pada kuadran IV penerima manfaat yang dikategorikan miskin secara absolut, juga ikut menurun sebesar 0,3%. Hasil Uji Beda juga menunjukan ada perbedaan indeks spiritual maupun indeks material penerima manfaat antar sebelum dan sesudah pemberian dana ZIS dibuktikan dengan Uji Beda Wilcoxon untuk indeks material value, dan Uji T berpasangan untuk indeks spiritual value.. Dengan adanya hasil penilaian kaji dampak ini diharapkan dampak dari bantuan yang diberikan bisa terukur dan juga menjadi bahan evaluasi serta perencanaan untuk program-program yang akan datang. Implikasi temuan penelitian ini dapat memberikan refrensi terkait manfaat zakat, infak, sedekah dalam membantu mengetaskan kemiskinan yang dilakukan oleh lembaga amil zakat nasional. Secara praktik, Lembaga Manajemen Infaq perlu memberikan perhatian khusus kepada mustahik yang berada di kategori miskin absolut, dengan memberikan intervensi ekonomi dan pembinaan secara spiritual. Kata Kunci: Kaji Dampak, ZIS, Kemiskinan, CIBEST, Lemabga Amil Zakat, Lembaga Manajemen Infaq. ABSTRACT Poverty is a problem that must find a way to eradicate. Islam, the perfect religion, has provided a solution through the instruments of zakat, infaq, and shadaqah. The purpose of this study was to assess the impact of Zakat, Sedekah, and Infaq in Lembaga Manajemen Infaq with the CIBEST Approach. The method used is quantitative by distributing questionnaires and testing the difference between the material and spiritual conditions of the mustahik before being assisted with after the ZIS funds are distributed. The results of the analysis of 355 beneficiaries showed that in quadrant I, beneficiaries categorized as prosperous increased by 28% after being assisted. In quadrant II, beneficiaries categorized as materially poor decreased by 27.7%. In addition, in quadrant IV, beneficiaries who are categorized as absolute poor also decreased by 0.3%. The results of the Difference Test also show that there are differences in the spiritual index and material index of beneficiaries between before and after the provision of ZIS funds, as evidenced by the Wilcoxon Difference Test for the material value index, and the paired T-test for the spiritual value index. The assistance provided can be measured and can also be used as material for evaluation and planning for future programs. The implications of the findings of this study can provide a reference regarding the benefits of zakat, shadaqah, and infaq in helping to alleviate poverty carried out by the national amil zakat institution. In practice, Amil Zakat Organization needs to pay special attention to mustahik who are in the absolute poor category, by providing economic intervention and spiritual guidance. Keywords: Assessment of Impact, ZIS, Poverty, CIBEST, Amil Zakat Organization, Lembaga Manajemen Infaq. DAFTAR PUSTAKA Ahmed, B. O., Johari, F., & Wahab, K. A. (2017). Identifying the poor and the needy among the beneficiaries of zakat Need for a zakat-based poverty threshold in Nigeria. International Journal of Social Economics, 44(4), 446–458. https://doi.org/10.1108/IJSE-09-2015-0234 Amalia, & Mahalli, K. (2012). Analisis peran zakat dalam mengurangi kemiskinan: Studi kasus dompet dhuafa republika. Jurnal Ekonomi dan Keuangan. Andam, A. C., & Osman, A. Z. (2019). Determinants of intention to give zakat on employment income: Experience from Marawi City, Philippines. Journal of Islamic Accounting and Business Research, 10(4), 528–545. https://doi.org/10.1108/JIABR-08-2016-0097 Ashar, M. A., & Nafik, M. (2019). Implementasi metode CIBEST (Center of Islamic business and economic studies) dalam mengukur peran zakat produktif terhadap pemberdayaan mustahiq di lembaga yayasan dana sosial al-falah (ydsf) Surabaya. Jurnal Ekonomi Syariah Teori dan Terapan, 6(5). 1057-1071. https://doi.org/10.20473/vol6iss20195pp1057-1071 Asian Development Bank. (2021). Daftar negara dengan penduduk hidup di bawah garis kemiskinan terbanyak di Asia Tenggara. Retrieved from https://databoks.katadata.co.id/datapublish/2021/11/19/daftar-negara-dengan-penduduk-hidup-di-bawah-garis-kemiskinan-terbanyak-di-asia-tenggara Asmalia, S., Kasri, R. A., & Ahsan, A. (2018). Exploring the potential of zakah for supporting realization of sustainable development Goals (SDGs) in Indonesia. International Journal of Zakat, 3(4), 51–69. https://doi.org/10.37706/IJAZ.V3I4.106 Ayuniyyah, Q., Pramanik, A. H., Md Saad, N., & Ariffin, M. I. (2022). The impact of zakat in poverty alleviation and income inequality reduction from the perspective of gender in West Java, Indonesia. International Journal of Islamic and Middle Eastern Finance and Management. Vol. ahead-of-print No. ahead-of-print. https://doi.org/10.1108/IMEFM-08-2020-0403 Ayyubi, S. el, & Saputri, H. E. (2018). Analysis of the impact of zakat, infak, and sadaqah distribution on poverty alleviation based on the CIBEST model (Case study: Jogokariyan baitul maal mosque, Yogyakarta). In International Journal of Zakat, 3(2), 85-97. https://doi.org/10.37706/ijaz.v3i2.80 Beik, I. S., & Arsyianti, L. D. (2015). Construction of CIBEST model as measurement of poverty and welfare indices from Islamic perspective. Al-Iqtishad: Jurnal Ilmu Ekonomi Syariah, 7(1), 87–104. https://doi.org/10.15408/AIQ.V7I1.1361 Beik, I. S., & Arsyianti, L. D. (2016). Measuring zakat impact on poverty and welfare using Cibest model. Journal of Islamic Monetary Economics and Finance, 1(2), 141–160. https://doi.org/10.21098/JIMF.V1I2.524 Beik, I. S., & Arsyianti, L. D. (2017). Ekonomi pembangunan syariah. Surabaya: Rajagrafindo Persada. BPS. (2022). Persentase penduduk miskin September 2021 turun menjadi 9,71 persen. Retrieved from https://www.bps.go.id/pressrelease/2022/01/17/1929/persentase-penduduk-miskin-september-2021-turun-menjadi-9-71-persen.html Efendi, M. S., & Fathurrohman, M. S. (2021). Dampak zakat terhadap kesejahteraan material dan spiritual mustahik (Studi kasus baznas microfinance desa sawojajar). Jurnal Ekonomi Syariah Teori dan Terapan, 8(6), 686-695. https://doi.org/10.20473/VOL8ISS20216PP686-695 Ghahari, S., Khademolreza, N., Ghasemnezhad, S., Babagholzadeh, H., & Ghayoomi, R. (2018). Comparison of anxiety and depression in victims of spousal abused and non-abused women in primary health care (PHC) in Babol-Iran. UCT Journal of Social Science and Humanities Research, 6(2), 14-18. https://doi.org/10.24200/jsshr.vol6iss02pp14-18 Halimatussakdiyah, & Nurlaily. (2021). Analisis pendayagunaan zakat produktif dalam mengurangi kemiskinan berdasarkan model Cibest (Studi kasus badan amil zakat nasional Prov Sumut). At-Tawassuth: Jurnal Ekonomi Islam, 1(Januari –Juni 2021), 12–25. 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Analisis dampak pendistribusian dana zakat terhadap tingkat kemiskinan mustahik dengan menggunakan model Cibest (Studi kasus: LAZ dompet dhuafa daerah istimewa Yogyakarta). Skripsi tidak dipublikasikan. Yogyakarta: UIN Sunan Kalijaga. Nisa, N. I. (2022). Penerapan model CIBEST dalam pengentasan kemiskinan di Indonesia. Retrieved from https://kumparan.com/naylazzatnsa/penerapan-model-cibest-dalam-pengentasan-kemiskinan-di-indonesia-1xkNF2L43tu/full Obaidullah, M. (2008). Introduction to Islamic microfinance. India: IBF Net (P) Limited. Owoyemi, M. Y. (2020). Zakat management: The crisis of confidence in zakat agencies and the legality of giving zakat directly to the poor. Journal of Islamic Accounting and Business Research, 11(2), 498–510. https://doi.org/10.1108/JIABR-07-2017-0097 Pistrui, D., & Fahed-Sreih, J. (2010). Islam, entrepreneurship and business values in the Middle East. International Journal of Entrepreneurship and Innovation Management, 12(1), 107–118. https://doi.org/10.1504/IJEIM.2010.033170 Puskas BAZNAS. (2016). Kaji dampak penyaluran zakat baznas terhadap kesejahteraan mustahik tahun 2016. Jakarta: Puskas BAZNAS. Putri, O. R. (2020). Hubungan antara spiritualitas dengan kebermaknaan hidup pada remaja di panti asuhan budi mulya sukarame Bandar Lampung. Skripsi tidak dipublikasikan. Lampung: UIN Raden Intan. Rahmat, R. S., & Nurzaman, M. S. (2019). Assesment of zakat distribution: A case study on zakat community development in Bringinsari village, Sukorejo district, Kendal. International Journal of Islamic and Middle Eastern Finance and Management, 12(5), 743–766. https://doi.org/10.1108/IMEFM-12-2018-0412 Reza Dasangga, D. G., & Cahyono, E. F. (2020). Analisis peran zakat terhadap pengentasan kemiskinan dengan model Cibest (Studi kasus rumah gemilang Indonesia kampus Surabaya. 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PurposeHomelessness is a colossal issue, precipitated by a wide array of social determinants, and mirrored in substantial health disparities and a revolving hospital door. Connecting people to safe and secure housing needs to be part of the health system response. The paper aims to discuss these issues.Design/methodology/approachThis mixed-methods paper presents emerging findings from the collaboration between an inner city hospital, a specialist homeless medicine GP service and Western Australia’s inaugural Housing First collective impact project (50 Lives 50 Homes) in Perth. This paper draws on data from hospitals, homelessness community services and general practice.FindingsThis collaboration has facilitated hospital identification and referral of vulnerable rough sleepers to the Housing First project, and connected those housed to a GP and after hours nursing support. For a cohort (n=44) housed now for at least 12 months, significant reductions in hospital use and associated costs were observed.Research limitations/implicationsWhile the observed reductions in hospital use in the year following housing are based on a small cohort, this data and the case studies presented demonstrate the power of care coordinated across hospital and community in this complex cohort.Practical implicationsThis model of collaboration between a hospital and a Housing First project can not only improve discharge outcomes and re-admission in the shorter term, but can also contribute to ending homelessness which is itself, a social determinant of poor health.Originality/valueCoordinated care between hospitals and programmes to house people who are homeless can significantly reduce hospital use and healthcare costs, and provides hospitals with the opportunity to contribute to more systemic solutions to ending homelessness.

e4849150In this work, Elinor Ostrom's ideas on common goods (1990, 1996) are recovered with the aim of analyzing her contributions to the co-production of scientific knowledge. From a descriptive and analytical approach based on two of his research works, his notions of institutional management are analyzed, which allow him to establish a relationship with the themes of science, technology and society when conceptualizing scientific knowledge committed to social well-being; at the same time, it allows us to establish a possible relationship with extra-academic sectors (NAIDORF; VASEN; ALONSO, 2016) that it is intended to highlight. In conclusion, an outline of the co-production process is presented as the crystallization of a model that starts from the notion of collaborative and relational science. Likewise, a change in the conception of scientific knowledge in the region is advocated and a paradigmatic case in Argentina that incorporates the role of the so-called extra-academic actors is exposed: the Scientific and technological development projects.ResumenEn este trabajo se recuperan las ideas de Elinor Ostrom sobre bienes comunes (1990, 1996) con el objetivo de analizar sus aportes a la coproducción del conocimiento científico. Desde un enfoque descriptivo y analítico basado en dos de sus trabajos de investigación, se analizan sus nociones de gestión institucional que permiten entablar una relación con las temáticas de ciencia, tecnología y sociedad a la hora de conceptualizar un conocimiento científico comprometido con el bienestar social; al mismo tiempo, nos permite entablar una posible relación con sectores extraacadémicos (NAIDORF; VASEN; ALONSO, 2016) que se pretende destacar. Como conclusión, se presenta un esbozo del proceso de coproducción como la cristalización de un modelo que parte de la noción de ciencia colaborativa y relacional. Asimismo, se propugna por un cambio en la concepción del conocimiento científico en la región y se expone un caso paradigmático en Argentina que incorpora el rol de los llamados actores extraacadémicos: los Proyectos de desarrollo científico y tecnológicos.ResumoNeste trabalho, as ideias de Elinor Ostrom sobre bens comuns (1990, 1996) são recuperadas com o objetivo de analisar suas contribuições para a coprodução do conhecimento científico. A partir de uma abordagem descritiva e analítica baseada em dois de seus trabalhos de pesquisa, são analisadas suas noções em gestão institucional que lhe permitem estabelecer uma relação com os temas da ciência, tecnologia e sociedade ao conceber o conhecimento científico comprometido com o bem-estar social; ao mesmo tempo, permite estabelecer uma possível relação com setores extra-acadêmicos (NAIDORF; VASEN; ALONSO, 2016) que se pretende destacar. Em conclusão, é apresentado um esboço do processo de coprodução como a cristalização de um modelo que parte da noção de ciência colaborativa e relacional. Da mesma forma, defende-se uma mudança na concepção do conhecimento científico na região e expõe-se um caso paradigmático na Argentina que incorpora o papel dos chamados atores extra-acadêmicos: os Projetos de Desenvolvimento Científico e Tecnológico.Palabras claves: Bienes comunes, Coproducción, Conocimiento científico, Proyectos de desarrollo científico y tecnológico (PDTS).Palavras-chave: Bens comuns, Co-produção, Conhecimento científico, Projetos de desenvolvimento científico e tecnológico (PDTS).Keywords: Common goods, Co-production, Scientific knowledge, Scientific and technological development projects (PDTS).ReferencesARZA,V.; FRESSOLI, M. Ciencia abierta en Argentina: experiencias actuales y propuestas para impulsar procesos de apertura. En: CIENCIA ABIERTA PARA LA INNOVACIÓN EN ARGENTINA. Buenos Aires: Centro de Investigaciones para la Transformación (Cenit), 2006. Disponible en: http://www.ciecti.org.ar/wp-content/uploads/2016/09/CIECTI-Proyecto-CENIT.pdfMINISTERIO DE CIENCIA Y TECNOLOGÍA. PDTS: Documento II. Buenos Aires, 2013. Disponible en: https://www.argentina.gob.ar/ciencia/banco-pdts. Acceso 7 de mayo 2020.BOURDIEU, P. Homo academicus, Siglo XX Editores, 2012.BUSANICHE, B. LAS IDEAS Y LAS COSAS: LA RIQUEZA DE LAS IDEAS Y LOS PELIGROS DE SU MONOPOLIZACIÓN. En: VILLARREAL, J.; HELFRICH, S.; CALVILLO, A. (eds.). ¿Un mundo patentado? La privatización de la vida y del conocimiento. El Salvador: Ediciones Böll. Disponible: https://www.vialibre.org.ar/2005/10/02/un-mundo-patentado/ENCABO, J. V. Ciencia privada, conocimiento público. Algunas determinantes de las controversias políticas en la era de la tecnociencia. Revista Isegoría, N.º 25, p. 247-261, 2001.ESTÉBANEZ, M. E.. Ciencia, tecnología y políticas sociales. Revista Ciencia, docencia y tecnología, N.º 34, p.13- 63, 2007.GONZÁLEZ ALCAIDE G.; GÓMEZ FERRI, J. La colaboración científica: principales líneas de investigación y retos de futuro. Revista Española de Documentación Científica, Vol. º 37, N.º 4, 2014. Disponible en: http://dx.doi.org/10.3989/redc.2014.4.1186KREIMER, P. La ciencia como objeto de las ciencias sociales en América latina: investigar e intervenir. Cuadernos de pensamiento crítico latinoamericano. Buenos Aires: CLACSO, 2015.HARDIN, G. The Tragedy of the Commons. Revista Science 13. Vol. 162, N°. 3859 pp. 1243-1248, 1968. [en línea]. <http://www.sciencemag.org/content/162/3859/1243.full> Acceso: 6 de mayo 2020.HESS, CH.; OSTROM, E. Introduction: An Overview of the Knowledge Commons. En: Understanding Knowledge as a Commons From Theory to Practice, Cambridge MAS: MIT PRESS, p.3-24, 2007.HURTADO D; ZUBELDÍA L. Políticas de ciencia, tecnología y desarrollo, ciclos neoliberales y procesos de des-aprendizaje en América Latina. Ciudad de México UDUAL - Unión de Universidades de América Latina y el Caribe, vol. 5, 2018.LARA RIVERO, A. Introducción. En: Comprender la diversidad institucional. México DF: Fondo de Cultura Económica, p. 9-35, 2014.NAIDORF, J. La privatización del conocimiento público en universidades públicas. En: Espacio público y privatización del conocimiento. Buenos Aires: CLACSO, p. 101-162, 2005.NAIDORF, J. Los cambios en la cultura académica de la universidad pública. Buenos Aires: Eudeba, 2015.NAIDORF, J., & PERROTTA, D. La privatización del acceso abierto. Nuevas formas de colonización académica en América Latina y su impacto en la evaluación de la investigación. Revista Universidades, N.º 73, p. 41-50, 2017.NAIDORF, J.; VASEN,F.; ALONSO, M. Evaluación académica y relevancia productiva. Los Proyectos de Desarrollo Tecnológico y Social como política científica, Brazilian Journal of Latin American Studies (PROLAM/USP), N.º 27, p. 2015.OLMOS-PEÑUELA, J.; CASTRO-MARTÍNEZ, E. y D’ESTE P. Knowledge transfer activities in social sciences and humanities: Explaining the interactions of research groups with non-academic agents, Research Policy, N.º 43. 696-706, 2014.OLSON, Mancur. The Logic of Collective Action: Public Goods and the Theory of Groups. Cambridge, MA: Harvard University Press, 1965.OSTROM, E. “Crossing the Great Divide: Coproduction, Synergy, and Development”, Revista World Development, N.º 24, págs. 1073-1087, 1996.OSTROM, E. “A Behavioral Approach to Rational Choice Theory of Collective Action”, American Political Science Review, N.º 92, págs. 1-2, 1998.OSTROM, E. El gobierno de los bienes comunes: la evolución de instituciones de acción colectiva. México DF: Fondo de Cultura Económica, 2000.OSTROM, E. A Behavioral Approach to the Rational Choice Theory of Collective Action: Presidential Address, American Political Science Association. The American Political Science Review, Vol. 92, No. 1, pp. 1-22, 1998.RAMIS OLIVO, A. El concepto de bienes comunes en la obra de Elinor Ostrom, Página Ecología Política, 2013. Extraído de:https://www.ecologiapolitica.info/?p=957 (en línea). Acceso: 6 de mayo 2020.RINESI, E. La universidad como derecho de los ciudadanos y del pueblo. En: Universidad pública y desarrollo: innovación, inclusión y democratización del conocimiento. Buenos Aires: IEC-CONADU, 2015.RIN/NESTA. 'Open to All? Case studies of openness in research', Página oficial de Research Information Network (RIN) and National Endowment for Science, Technology and the Arts (NESTA), London, 2010. Disponible en: http://www.rin.ac.uk/system/files/attachments/NESTA-RIN_Open_Science_V01_0.pdfSENEJKO, P.; VERSINO, M. “La producción de conocimientos y la resolución de problemas sociales: Análisis de las convocatorias a proyectos de investigación orientados en la UBA (2003-2015)” Revista Horizontes Sociológicos, Asociación Argentina de Sociología, 2018.SIRVENT, M.T; LLOSA. S. Jóvenes y adultos en situación de riesgo educativo: análisis de la demanda potencial y efectiva. Revista del Instituto de Investigaciones en Ciencias de la Educación, N.º 12, 12-27, 1998.VACCAREZZA, L. El campo CTS en América Latina y el uso social de su producción. Revista Iberoamericana de Ciencia, Tecnología y Sociedad- CTS, vol. 1, núm. 2. Centro de Estudios, 2004.VACCAREZZA, L. Las relaciones de utilidad en la investigación social, Revista Mexicana de Sociología, N.º 71, p. 133-166, 2009.

Purpose Lorentz force evaluation is a non-destructive evaluation method for conducting specimens. The movement of a specimen relative to a permanent magnet leads to Lorentz forces that are perturbed in the presence of a defect. This defect response signal (DRS) is used for defect reconstruction. To solve a linear inverse problem for defect reconstruction, an accurate and fast forward computation method is required. As existing forward methods are either too slow or too inaccurate, the purpose of this paper is to propose the single voxel approach (SVA) as a novel method. Design/methodology/approach In SVA, the DRS is computed as a superposition of DRSs from single defect voxels, which are calculated in advance, by applying the boundary element source method. This research uses a setup of an isotropic conducting specimen, a spherical permanent magnet and defects of different shapes at different depths. With the help of simulations, this study compares the SVA to the previously proposed approximate forward solution (AFS) and the extended area approach (EAA) using the normalized root mean square error (NRMSE). Simulated data using the finite element method serve as the reference solution. Findings SVA shows across all simulations NRMSE values <2.5 per cent compared to <8 per cent for EAA and <12 per cent for AFS. Originality/value The superposition principle of SVA allows for the application of linear inverse methods for defect reconstruction while providing sufficient accuracy of the forward method.

Purpose Social media as a competitive marketing tool deliver online platforms for retailers to get closer to their consumers/visitors/shoppers through continued interaction. The purpose of this paper is to scrutinize how customer values (functional, social and experimental) enhance satisfaction, loyalty and identification, and how such relationships, in turn, impact users’ continuance interaction intention. Design/methodology/approach A mixed-method approach was designed to identify the consumers’ perception toward high-end retailers of worldwide brands. In all, 12 interviews with experts in retailing and a survey among 390 respondents were conducted. Structural equation modeling/AMOS was employed to gain insight into the various relationships and influences. Findings To augment users’ continuance interaction intention, the results indicate that retail managers should focus more on customer-based values when they design marketing strategies for brand pages on social media. The findings also provide guidelines for retail marketing and social media managers to generate consumer value in the retail environment via information quality, product-related learning and economic benefits (functional value); interaction, collaboration and social presence (social value); and experiential value (intellectual and effective value). Originality/value The paper offers critical managerial contributions by presenting a comprehensive picture of the condition in which a favorable brand social media page could be constructed within a brand to satisfy consumer value and achieve satisfaction, loyalty, identification and continuance interaction intention, all of which are critical objectives for every company. In other words, a clear knowledge of the dimensions of consumer value concepts can assist retail communication managers to improve consumers’/visitors’/shoppers’ intention to continue their interaction in a competitive market. The current study is one of the very few emerging research studies to have examined the relationships between consumers’/visitors’/shoppers’ functional values, social values and experimental values empirically, and to have further explored the relationships between the research constructs.

The variety study of white lupine plants in the Belgorod region was carried out in field trials at the collection nursery of department of plant production, breeding and olericulture of the Belgorod State Agrarian University named after V.Ya. Gorin in 2018–2019. In the trial there were studied 4 varieties and 26 samples of white lupine of grain-fodder selection developed by the All-Russian Research Institute of Lupine, the variety ‘Michurinsky’ was taken as a standard one. Most of the samples in the trial significantly exceeded the standard variety in the value of seed productivity. In 2018 the highest yield of 4.86 t/ha was obtained from the sample ‘CH 40-15’, which was on 1.15 t/ha higher than that of the standard variety. A high yield from 4.19 to 4.82 t/ha was produced by the samples ‘СН 78-16’, ‘СН 20-13’, ‘СН 15-13’ and ‘СН 816-09’, which significantly exceeded the standard variety on 0.48–0.61 t/ha. Under the conditions of the year of 2019, a significant productivity increase (from 0.24 to 2.1 t/ha) in comparison with the standard variety was produced by 19 samples and two varieties ‘Pilgrim’ and ‘Timiryazevsky’. The largest productivity in the trial (5.26 and 5.24 t / ha) was produced by the samples ‘CH 54-08’ and ‘CH 12-13’. The yield increase of the samples ‘СН 77-17’, ‘СН 816-09’, ‘СН 1735-10’, ‘СН 17-14’ was 1.35–1.57 t/ha in comparison with the standard variety. The highest mean yield in the trial for 2 years (4.40–4.47 t/ha) was formed by the samples ‘СН 17-14’ and ‘СН 816-09’, their increase was 0.96–1.03 t/ha or 27.9–29.9% in comparison with the standard variety. The samples ‘СН 12-13’ and ‘СН 54-08’ showed the highest coefficient of adaptability in the trial at the level of 1.36–1.38. The most of the studied samples and the variety ‘Alyi Parus’ possessed the coefficient of adaptability >1, which characterizes them as highly adaptable to the arid conditions of the region. The most varieties and samples exceeded the standard value of the trait ‘seed weight per plant’ which is 4 g. The value of the trait ‘1000-seed weight’ in the trial varied from 234.8 g (the sample ‘CH 35-13’) to 302.6 g (the sample ‘CH 25-11’) in comparison with 264 g (the standard variety).

The Mw7.9 Alaska earthquake at 09:31:40 UTC on 23 January 2018 occurred as the result of strike slip faulting within the shallow lithosphere of the Pacific plate. Global positioning system (GPS) data were used to calculate the slant total electron contents above the epicenter. The singular spectrum analysis (SSA) method was used to extract detailed ionospheric disturbance information, and to monitor the co-seismic ionospheric disturbances (CIDs) of the Alaska earthquake. The results show that the near-field CIDs were detected 8–12 min after the main shock, and the typical compression-rarefaction wave (N-shaped wave) appeared. The ionospheric disturbances propagate to the southwest at a horizontal velocity of 2.61 km/s within 500 km from the epicenter. The maximum amplitude of CIDs appears about 0.16 TECU (1TECU = 1016 el m−2) near the epicenter, and gradually decreases with the location of sub-ionospheric points (SIPs) far away from the epicenter. The attenuation rate of amplitude slows down as the distance between the SIPs and the epicenter increases. The direction of the CIDs caused by strike-slip faults may be affected by the horizontal direction of fault slip. The propagation characteristics of the ionospheric disturbance in the Alaska earthquake may be related to the complex conditions of focal mechanisms and fault location.

The Mw7.9 Alaska earthquake at 09:31:40 UTC on 23 January 2018 occurred as the result of strike slip faulting within the shallow lithosphere of the Pacific plate. Global positioning system (GPS) data were used to calculate the slant total electron contents above the epicenter. The singular spectrum analysis (SSA) method was used to extract detailed ionospheric disturbance information, and to monitor the co-seismic ionospheric disturbances (CIDs) of the Alaska earthquake. The results show that the near-field CIDs were detected 8–12 min after the main shock, and the typical compression-rarefaction wave (N-shaped wave) appeared. The ionospheric disturbances propagate to the southwest at a horizontal velocity of 2.61 km/s within 500 km from the epicenter. The maximum amplitude of CIDs appears about 0.16 TECU (1TECU = 1016 el m−2) near the epicenter, and gradually decreases with the location of sub-ionospheric points (SIPs) far away from the epicenter. The attenuation rate of amplitude slows down as the distance between the SIPs and the epicenter increases. The direction of the CIDs caused by strike-slip faults may be affected by the horizontal direction of fault slip. The propagation characteristics of the ionospheric disturbance in the Alaska earthquake may be related to the complex conditions of focal mechanisms and fault location.

Purpose An integral feature of Special Guardianship Orders (SGO) is that the children should have some contact with their parents after the order is granted. Local authority social workers have a duty to plan and recommend levels and types of contact. But there is no policy guidance provided on how to undertake these duties, and little is known about the process that practitioners undertake. The purpose of this paper is to investigate the recommending of contact in special guardianship cases, and to provide data on what contact social workers are recommending the factors they take into consideration and the reasons for their decisions. Design/methodology/approach The research involved a mixed-methods approach comprising of a questionnaire and focus groups. This part of the study comprised of an online questionnaire that was completed by 102 local authority social workers. Responses were downloaded into SPSS Statistics v22 for data analysis and a content analysis was conducted. Findings Quantitative results from the questionnaire are reported in this paper. Respondents provided comprehensive details on what they include in their recommendations, including levels of contact frequency and specific directions. Practitioners rated the factors they considered in reaching their decisions, and gave their general views on special guardianship contact. Results indicated that practitioners are recommending less contact for fathers than for mothers, and may feel less positively about paternal contact. Bivariate analysis suggests that some older and more experienced social workers are recommending lower levels of contact. Research limitations/implications The statistical significance of the results was limited by the relatively small sample size. It was therefore decided to limit bivariate analyses to consideration of just three independent variables: the social worker’s age and number of years in practice, and the age of the child at the time of their SGO, against dependent variables concerning the levels of contact that had been recommended for mothers and fathers and how positive these were considered to be. Because of the limited sample size, most of the results were above this level, and so were not statistically significant. Practical implications Special guardianship has been in place for 12 years now, but apart from Jim Wade’s 2014 study there has been no major research to guide and inform practice. Such major changes in child welfare require substantiating research, and this study is an attempt to begin filling that gap. The questionnaire part of this study has for the first time provided data on the views, motivations and practice of social workers across the country making recommendations on special guardianship contact. Social implications The study provides a picture of the type of contact being recommended for birth parents. This information will be useful for practitioners, who might otherwise not know what their colleagues in other local authorities are recommending, and it is hoped that this will encourage further debate on the subject. Originality/value Special guardianship has so far been poorly served by research. To the author’s knowledge, apart from Wade’s study there is very little research on the subject, and no significant research at all on special guardianship contact. This questionnaire, alongside the four focus groups that formed the second part of the study, provides the first picture of current practice across the country.

Abstract Multi-species livestock grazing is a common practice in the Edwards Plateau of Texas. Winter demands on livestock are high because of forage quality and quantity limitations and stresses of tick parasitism. Our objective was to assess winter-active tick burden on livestock and gauge effectiveness of a pour-on synthetic pyrethroid acaricide. At the Sonora AgriLife Station, 26 Bos taurus crossbred heifers (260 ± 6 kg) and 28 Dorper ewes (42 ± 1 kg) were maintained on 97.125 hectares of rangeland. Tick burden was assessed by individual animal inspection on: 12-18-2017, 01-05-2018, 01-122018, 01-26-2018, 02-09-2018, 02-16-2018, 02-23-2018, and 03-08-2018. Trial 1 acaricide treatment was applied 01-05-2018 on heifers and ewes chosen randomly to serve in the non-treated control (13 heifers; 14 ewes) or acaricide-treated (13 heifers; 14 ewes) groups. Trial 2 acaricide treatment was applied 02-16-2018 using a switchback design. Tick species included Amblyomma americanum, Dermacentor albipictus, and Ixodes scapularis. Tick burden differences were determined by analysis of variance procedures. There were no differences in tick burden on heifers or ewes prior to acaricide application for Trial 1 nor Trial 2 (P > 0.276, 0.002 ± 0.46; P > 0.354, 0.002 ± 0.11 and P > 0.606, 0.002 ± 0.05; P > 0.705, 0.001 ± 1.34, respectively). There were no differences (P > 0.149) between acaricide-treated (0.519 ± 0.05) and non-treated control (0.644 ± 0.07) heifers in Trial 1 nor Trial 2 (0.759 ± 0.07 and 0.404 ± 0.04, respectively). Similarly, there were no differences (P > 0.997) between acaricide-treated (2.964 ± 0.31) and non-treated control (2.965 ± 0.3) ewes in Trial 1 nor Trial 2 (1.015 ± 0.13 and 5.563 ± 0.45, respectively). We conclude ticks challenge the well-being and production in overwintering livestock in the Edwards Plateau. Alternative acaricides should be evaluated for efficacy and efficiency in these production systems

ABSTRAK Penurunan profit bisnis kecil akibat implikasi ekonomi pasca pandemi COVID-19. Persoalan struktur permodalan menjadi kendala dalam mempertahankan dan meningkatkan usahanya secara terus menerus seiring kerubahan zaman. Koperasi Syariah sebagai salah satu lembaga keuangan Islam yang keislaman lebih dekat secara eksistensi maupun teritorial dengan masyarakat tingkat bawah sehingga menjadi alternatif pengembangan usaha masyarakat secara syariah sesuai persyaratan yang diberikan. Studi ini bertujuan untuk untuk menganalisis pengaruh literasi keuangan syariah dalam sikap, pengaruh sosial dan self-efficacy terhadap perilaku pemanfaatan produk koperasi syariah di Indonesia. Studi kuantitatif survey online dengan melibatkan 280 calon anggota koperasi syariah yang membutuhkan pembiayaan dan merupakan pemilik UMKM dijalankan dengan teknik analisis SEM PLS. Hasil studi menunjukkan pengaruh literasi keuangan terhadap sikap, pengaruh sosial dan self-efficacy lalu dilanjutkan arah jalur dukungan hipotesis terhadap niat untuk memilih Koperasi Syariah sebagai solusi kebutuhan finansial UMKM ditemukan. Strategi manajerial khususnya pemasaran dikembangkan dengan mempertimbangkan efek sikap positif, pengaruh sosial dan efikasi diri calon anggota sebagai pemilik bisnis atau produk keuangan syariah yang akan mereka tawarkan kepada pelanggan mereka akan berkontribusi pada pertumbuhan sektor UMKM khususnya UMKM Generasi Millenial dan UMKM Hijau di Indonesia melalui upaya promosi dan kerjasama. Kata Kunci: ASE Model, Ekonomi Islam, Koperasi Syariah, Pemberdayaan, UMKM. ABSTRACT The decline in small business profits due to the post-COVID-19 pandemic economy. The issue of capital structure is an obstacle in maintaining and increasing development continuously in line with the changing times. Sharia cooperatives as one of the Islamic financial institutions are closer in existence and territorially to the lower level of society so that they become an alternative for community business development in accordance with the requirements given. This study aims to analyze the effect of Islamic financial literacy on attitudes, social influence and self-efficacy on the application of Islamic cooperative products in Indonesia. Quantitative study of online surveys involving 280 prospective members of Islamic cooperatives who need financing and are MSME owners carried out with the PLS SEM analysis technique. The results of the study show the effect of financial literacy on attitudes, social influence and self-efficacy, then choosing the direction of hypothesis support for the intention to find Islamic Cooperatives as a solution to the financial needs of MSMEs. Managerial strategies especially marketing that are developed taking into account the effects of positive attitudes, social influence and self-efficacy of prospective members as owners or Islamic financial products that they will offer to their customers will increase the growth of the MSME sector, especially Millennial Generation MSMEs and Green MSMEs in Indonesia through promotional efforts and cooperation. Keywords: ASE Model, Islamic Economics, Sharia Cooperatives, Empowerment, MSMEs. REFERENCES Abourrig, A. (2021). Social influence in predicting Islamic banking acceptance: Evidence from Morocco. International Journal of Accounting, Finance, Auditing, 2(2), 42–56. https://doi.org/10.5281/zenodo.4641472 Ajzen, I. (1991a). The theory of planned behavior. Organizational Behavior and Human Decision Processes, 50(2), 179–211. https://doi.org/10.1016/0749-5978(91)90020-T Ajzen, I. (1991b). The theory of planned behavior. 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ABSTRAK Penelitian ini bertujuan untuk memetakan penelitian-penelitian sebelumnya tentang audit syariah dan perannya dalam meningkatkan kepatuhan syariah di lembaga keuangan syariah (LKS). Penelitian ini juga menguraikan tantangan yang dihadapi oleh LKS dan solusi dalam mengimplementasikan audit syariah. Sebanyak 308 publikasi diperoleh dari database Google scholar, Emerald Insight, Research Gate, Crossref, Microsoft Academic and Pubmed yang diakses dengan perangkat lunak Publish or Perish (PoP) dalam kurun waktu 2008-2021. Studi ini menerapkan analisis bibliometrik menggunakan VOSviewer, yang mengubah metadata publikasi menjadi visualisasi sesuai dengan co-occurrence. Hasil penelitian ini menemukan bahwa audit syariah telah diterapkan di beberapa negara yang didominasi oleh Malaysia. Sebagian besar praktik audit syariah merupakan bagian dari fungsi audit internal. Audit syariah diidentifikasi sebagai mekanisme untuk memastikan kepatuhan syariah. Tantangan utama dalam pelaksanaan audit syariah antara lain: kurangnya kerangka dan standar audit syariah yang menyebabkan perselisihan di antara praktisi LKS, kurangnya auditor syariah yang berkualitas yang memiliki pengetahuan syariah yang memadai dan terlatih dengan baik, audit syariah dianggap menciptakan masalah inefisiensi. Peran komite tata kelola syariah dan dewan pengawas syariah direkomendasikan agar lebih optimal untuk memastikan efektivitas audit syariah. Penelitian ini memberikan pembahasan komprehensif tentang audit syariah, perannya dalam meningkatkan kepatuhan syariah, tantangan dan solusi yang ditawarkan belajar dari berbagai negara. Kata Kunci: Audit syariah, kepatuhan syariah, lembaga keuangan syariah, bibliometrik. ABSTRACT This study aimed to map out previous studies on sharia auditing and its role in improving sharia compliance in Islamic financial institutions (IFIs). It also outlined the challenges faced by IFIs and solutions in implementing shariah audit. A total of 308 publications were obtained from the Google scholar database, Emerald Insight, Research Gate, Crossref, Microsoft Academic and Pubmed which were accessed using the Publish or Perish (PoP) software in the 2008-2021 period. This study finds that sharia audits have been implemented in several countries, dominated by Malaysia. Most shariah audit practices are part from internal audit function of IFIs. Sharia audit is identified as a mechanism to assure shariah compliance. The main challenges in implementing sharia audit include: a lack of framework and standard of shariah audit that led to dispute among IFIs practitioners, a lack of qualified shariah auditors who have an adequate shariah knowledge and well trained , shariah audit identifed creating an efficiency issue. The role of the shariah governance committee and the shariah supervisory board may be optimized to ensure the effectiveness of shariah audit. 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Purpose Special guardianship order (SGO) assessments require social workers to make plans and recommendations for ongoing post-SGO contact between the child and the parents. However, there is very little policy to inform and guide practitioners on how these duties should be undertaken, and no studies that describe current practice. The purpose of this paper is to investigate how the recommending of contact in special guardianship cases is currently working, by holding focus groups with social workers and special guardians. This paper reports on the results of a study to examine what contact plans social workers are recommending, the thinking behind their decisions and the views of the special guardians who have to make those plans work. Design/methodology/approach The research involved a mixed methods approach comprising of an online questionnaire, two focus groups for social workers and two focus groups for special guardians. This paper describes the second part of the study and reports on the qualitative results from the four focus groups. The methodology was based on a pragmatist theoretical position, and used an interpretivist approach and elements of the analytical procedure of grounded theory in order to generate inductive research. The focus group method was chosen as the best way to gather rich information on the opinions and ideas of practitioners who are recommending contact and the carers who are managing it. Findings Participants provided a wide range of views on the issues, with practitioners describing the challenges of planning contact, and special guardians explaining the problems they faced with the parents. Involving special guardians in the study gave a chance to include the different perspectives of the people who have to make the contact recommendations work, and contrast their views on contact planning with those of the professionals. The study makes recommendations for practice, which recognise the difficulty of preparing an initial contact plan that will remain relevant for years ahead. Research limitations/implications The number of focus groups the author held was limited by the author’s own personal resources and the time the author had available, and one group only had three social workers on the day. The author’s involvement affected the responses, and the author’s questions dictated the issues that were commented on, but the answers were the opinions that the participants wanted to express. The nature of the approach means that no two sets of focus group results would ever be the same. And as the direction of the discussions was largely dictated by the participants, the coverage of all aspects of contact was probably inconsistent. Practical implications This research sheds light on a crucial area of social work permanency planning, that has suffered from a lack of previous research, in order to better inform future practice. The paper reports on what contact plans social workers are recommending, the thinking behind their decisions and the views of the special guardians who have to make those plans work. It concludes with recommendations for improving future special guardianship policy and practice. Social implications The research clearly raises a number of specific difficulties faced by special guardians and problems with current policy and practice. These include the special guardians’ lack of understanding about contact, the difficulty for social workers of long-term planning, the challenge posed by uncooperative parents who behave badly, the view of carers for the need for a greater emphasis on the quality and reliability of contact, and the challenge to careful contact planning posed by the adversarial court process. Originality/value Special guardianship has had a major impact on permanency planning since its introduction 12 years ago. However, apart from one DfE study in 2014, very little research has been produced to inform policy and practice. There have been no studies specifically on contact in special guardianship cases, despite contact being one of the two major factors in determining the success of SGO placements. This study has provided the first in-depth evaluation of social worker contact planning in special guardianship, and the first investigation of special guardians’ views on contact.

ABSTRAK Tujuan dari penelitian ini untuk menganalisis pengaruh label halal, harga dan Song Joong Ki sebagai brand ambassador terhadap keputusan pembelian produk Scarlett Whitening di Kabupaten Sidoarjo. Penelitian ini menerapkan metode kuantitatif dengan sumber data primer dari kuesioner yang disebar secara online kepada responden yang memenuhi kriteria. Dalam pengambilan sampel menerapkan teknik purposive sampling untuk mendapatkan 100 responden. Teknik dalam pengolahan data menggunakan analisis SEM-PLS. Hasil dari penelitian diketahui terdapat pengaruh positif signifikan pada label halal, harga dan Song Joong Ki sebagai brand ambassador terhadap keputusan pembelian produk Scarlett Whitening. Hal tersebut terjadi karena label halal dan harga ialah aspek penting yang menjadi pertimbangan bagi konsumen dan Song Joong Ki sebagai brand ambassador berpengaruh dalam membujuk konsumen untuk melakukan pembelian. Implikasi hasil penelitian ini bagi industri kosmetik, diharapkan dapat mempertahankan adanya label halal pada produk serta memperhatikan penetapan harga dan pemilihan brand ambassador yang tepat karena hal tersebut memengaruhi keputusan pembelian. Dan bagi akademisi penelitian ini dapat menjadi rujukan ilmu. Kata Kunci: Label Halal, Harga, Brand Ambassador, Keputusan Pembelian. ABSTRACT The purpose of this study was to analyze the effect of halal labels, prices, and Song Joong Ki as a brand ambassador on purchasing decisions for Scarlett Whitening products in the Sidoarjo Regency. This study applies a quantitative method with primary data sources from questionnaires distributed online to respondents who meet the criteria. In taking the sample using the purposive sampling technique to get 100 respondents. Techniques in data processing using SEM-PLS analysis. The results of the study found that there was a significant positive effect on the halal label, price, and Song Joong Ki as a brand ambassador on the purchasing decision of Scarlett Whitening products. This happens because the halal label and price are important aspects that are considered by consumers and Song Joong Ki is an influential brand ambassador in persuading consumers to make a purchase. The implications of the results of this research for the cosmetic industry are expected to be able to maintain the existence of a halal label on the product and pay attention to pricing and selecting the right brand ambassador because it affects purchasing decisions. And for academics, this research can be a reference for knowledge. Keywords: Halal Label, Price, Brand Ambassador, Purchase Decision. DAFTAR PUSTAKA Achmad, D. N., & Fikriyah, K. (2021). Pengaruh halal knowledge, islamic religiosity dan kualitas produk terhadap keputusan pembelian produk wardah. Jurnal Ekonomika Dan Bisnis Islam, 4(3), 215–229. https://doi.org/10.26740/jekobi.v4n3.p215-229 Aeni, N., & Lestari, M. T. (2021). Pengaruh label halal, citra merek dan harga terhadap keputusan pembelian produk kosmetik wardah. Jurnal Ekonomi Bisnis, Manajemen Dan Akuntansi (JEBMA), 1(2), 117–126. https://doi.org/10.47709/jebma.v1i2.996 Az-zahra, A. F., & Sudrajat, R. H. (2021). The influence of NCT 127 brand ambassadors and advertising appeal on purchase decisions of Nature Republic product. EProceedings of Management, 8(5), 7017–7025. Badan POM. (2021). Badan POM ingatkan masyarakat untuk waspada terhadap peredaran kosmetik palsu berbahaya. Retrieved from https://www.pom.go.id/new/view/more/berita/21108/Badan-POM-Ingatkan-Masyarakat-untuk-Waspada-Terhadap-Peredaran-Kosmetik-Palsu-Berbahaya.html Badan Pusat Statistik. (2020). Pemeluk agama menurut agama dan kecamatan, 2018. Retrieved from https://sidoarjokab.bps.go.id/dynamictable/2020/03/25/15/pemeluk-agama-menurut-agama-dan-kecamatan-2018.html Badri, J., & Safitri, T. S. R. (2021). Pengaruh brand ambassador, minat beli dan testimoni terhadap keputusan pembelian online di instagram pada mahasiswa di kota Padang. Procuratio: Jurnal Ilmiah Manajemen, 9(4), 372–380. https://doi.org/10.35145/procuratio.v9i4.1377 Fathurrahman, A., & Anggesti, M. (2021). Pengaruh gaya hidup, label halal dan harga terhadap keputusan pembelian kosmetik (Studi kasus pada produk Safi). JES (Jurnal Ekonomi Syariah), 6(2), 113. https://doi.org/10.30736/jesa.v6i2.125 Fitriana, Sudodo, Y., & Hakim, L. (2019). Pengaruh gaya hidup, harga, dan kualitas produk terhadap keputusan pembelian kosmetik oriflame. Jurnal Manajemen Dan Bisnis, 2(1). https://doi.org/10.37673/jmb.v2i1.304 Ghozali, I. (2008). Structural equation modeling, teori, konsep dan aplikasi dengan program LISREL 8.80. Semarang: Badan Penerbit Universitas Diponegoro. Hair Jr., J. F., Gabriel, M. L. D. da S., & Patel, V. K. (2014). Modelagem de equações estruturais baseada em covariância (CB-SEM) com o AMOS: Orientações sobre a sua aplicação como uma Ferramenta de Pesquisa de Marketing. Revista Brasileira de Marketing, 13(2), 44–55. https://doi.org/10.5585/remark.v13i2.2718 Ismayana, S., & Hayati, N. (2018). Pengaruh kualitas produk dan harga terhadap keputusan pembelian produk lipstik pixy. Jurnal Sains Manajemen & Akuntansi, 8(2), 1–10. Keputusan Menteri Agama RI. (2001). Pedoman dan tata cara pemeriksaan dan penetapan pangan halal. Jakarta: Kemenag RI. Kominfo Jatim. (2021). Wapres tinjau kawasan industri halal di Sidoarjo. Retrieved from http://kominfo.jatimprov.go.id/read/umum/wapres-tinjau-kawasan-industri-halal-di-sidoarjo Kotler, P. (2000). Manajemen pemasaran. Jakarta: Prenhallindo. Kotler, P., & Amstrong, G. (2008). Prinsip-prinsip pemasaran Jilid 1 (ke-12). Surabaya: Erlangga. Kotler, P., & Amstrong, G. (2010). Prinsip-prinsip pemasaran Jilid 1 dan 2 (Ke-12). Surabaya: Erlangga. Kotler, P., & Keller, K. L. (2009). Manajemen pemasaran Jilid 1 (ke-13). Surabaya: Erlangga. Kusnandar, V. B. (2021). Sebanyak 86, 88 % penduduk Indonesia beragama Islam. Retrieved from https://databoks.katadata.co.id/datapublish/2021/09/30/sebanyak-8688-penduduk-indonesia-beragama-islam Lea-Greenwood, G. (2012). Fashion marketing communications. New York: Wiley. Lestari, A., & Septiana, N. (2021). Pengaruh label halal, religious commitment, brand ambassador dan desain produk terhadap keputusan pembelian kosmetik wardah (Studi pada mahasiswa Universitas Muhammadiyah Metro). Jurnal Manajemen, 1(2), 492–504. Lestari, I., Martin, Manullang, M., Butar-Butar, R. S., & Daulay, Z. R. (2021). The effect of brand ambasador and prices on the purchase decision of android hand phone through interest in buying consumers in Medan City. 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Objective: The aim of the study was to assess and compare the gelatinase activity and pellicle formation in extended-spectrum beta-lactamase (ESBL) and non-ESBL producing Acinetobacter baumannii isolates from diabetic foot ulcer infection (DFI).Methods: A total of 42 isolates of A. baumannii recovered from patients of DFI from September 2016 to February 2018. Isolates were identified by the standard microbiological method and confirmed by the BD Phoenix 100 system. The antimicrobial susceptibility test was performed by the Kirby–Bauer disk diffusion method and ESBL was detected by double disk diffusion synergy test method. Gelatinase production was determined by the Luria Bertani agar supplemented with 30 g/L gelatin, and pellicle formation was determined by the Mueller-Hinton broth which is incubated at two different temperatures.Results: A total of 42 A. baumannii isolates were multidrug resistant. Among 21 isolates, each was ESBL and non-ESBL producers. Pellicle formation at 25°C in ESBL and non-ESBL producer isolates was 47.61% (10/21) and 28.57% (06/21). Pellicle formation at 37°C in ESBL and non-ESBL producer isolates was 57.14% (12/21) and 42.85% (09/21), respectively. Gelatinase production was present in 38.09% ESBL and 28.57% in non-ESBL producers. ESBL strains were more virulent compared to non-ESBL producers among patients of DFIs.Conclusion: This study showed that pellicle formation at 37°C was highly virulent due to ESBL producers. Gelatinase production was elevated in ESBL compared to non-ESBL producer isolates. This attribute of the isolates could render ESBL positive more pathogenic. Colistin and polymyxin B are the only choices of treatment for multidrug-resistant Acinetobacter baumannii infections.

Abstract. Nowadays, the study of the upper atmosphere is increasing, mostly because of the need to understand the patterns of Earth's atmosphere. Since studies on global warming have become very important for the development of new technologies, understanding all regions of the atmosphere becomes an unavoidable task. In this paper, we aim to analyze the temperature variability and its trend in the mesosphere and lower thermosphere (MLT) region during a period of 12 years (from 2003 to 2014). For this purpose, three different heights, i.e., 85, 90 and 95 km, were focused on in order to investigate the upper atmosphere, and a geographic region different to other studies was chosen, in the southern region of Brazil, centered in the city of Santa Maria, RS (29∘41′02′′ S; 53∘48′25′′ W). In order to reach the objectives of this work, temperature data from the SABER instrument (Sounding of the Atmosphere using Broadband Emission Radiometry), aboard NASA's Thermosphere Ionosphere Mesosphere Energetics Dynamics (TIMED) satellite, were used. Finally, two cases were studied related to distinct grids of latitude/longitude used to obtain the mean temperature profiles. The first case considered a grid of 20∘ × 20∘ lat/long, centered in Santa Maria, RS, Brazil. In the second case, the region was reduced to a size of 15∘ × 15∘ in order to compare the results and discuss the two cases in terms of differences or similarities in temperature trends. Observations show that the size of the geographical area used for the average temperature profiles can influence the results of variability and trend of the temperature. In addition, reducing the time duration of analyses from 24 to 12 h a day also influences the trend significantly. For the smaller geographical region (15∘ × 15∘) and the 12 h daily time window (09:00–21:00 UT) it was found that the main contributions for the temperature variability at the three heights were the annual and semi-annual cycles and the solar flux influence. A smaller trend (−0.02 ± 0.16 % decade−1) was found at 90 km height and small positive trends (0.58 ± 0.26 % and 0.41 ± 0.19 % decade−1) were found at altitudes of 85 and 95 km, respectively.. Keywords. Atmospheric composition and structure (middle atmosphere – composition and chemistry; pressure, density, and temperature) – meteorology and atmospheric dynamics (climatology)

PurposeComposite laminates are considered one of the most popular damage-resistant materials when exposed to impact force in civil and military applications. In this study, a comparison of composites 12 and 20 layers of fabrics Kevlar and ultrahigh-molecular-weight poly ethylene (UHMWPE)-reinforced epoxy under low-velocity impacts represented by drop-weight impact and Izod pendulum impact has been done. During the Izod test, Kevlar-based composite showed damage at the composite center and fiber breakages. Whereas delamination was observed for UHMWPE reinforced epoxy (PE). The maximum impact strength was for Kevlar-reinforced epoxy (KE) and increases with the number of laminates. Drop-weight impact test showed the highest absorbed energy for (KE) composites. The results revealed that different behavior during the impact test for composites belongs to the impact mechanism in each test.Design/methodology/approachAramid 1414 Kevlar 49 and UHMWPE woven fabrics were purchased from Yixing Huaheng High-Performance Fiber Textile Co. Ltd, with specifications listed in Table 1. Epoxy resin (Sikafloor-156) is supplied from Sika AG. Sikafloor-156 is a two-part, low-viscosity, solvent-free epoxy resin, with compressive strength ∼95 N/mm², flexural strength ∼30 N/mm² and shore D hardness 83 (seven days). The mixture ratio of A/B was one-third volume ratio. Two types of laminated composites with different layers 12 and 20 were prepared by hand layup: Kevlar–epoxy and UHMWPE–epoxy composites as shown in Figure 1. Mechanical pressure was applied to remove bubbles and excess resin for 24 h. The composites were left in room temperature for seven days, and then composite plates were cut for the desired dimensions. Low-velocity impact testing, drop-weight impact, drop tower impact system INSTRON CEAST 9350 (see Figure 2) was facilitated to investigate impact resistance of composites according to ASTM D7137M (Test Method for Compressive, 2005). Low-velocity impact tests have been performed at room temperature for composite with dimensions 10 × 15 cm2 utilizing a drop tower (steel indenter diameter 19.85 mm as shown in Figure 3), height (800 mm), drop mass (5 kg) and speed (3.96 m/s). Special impact equipment consisting of vertically falling impactor was used in the test. The energy is obtained from Drop tower impact systems, (2009) E = ½ mv2 (2.1). The relationship between force–time, deformation–time and energy–time and deformation was obtained. Energy–deformation and force–deformation relationships were also obtained. The depth of penetration and the radius of impactor traces were recorded. Izod pendulum impact test of plastics was applied according to ASTM D256 (Test Method for Compressive, 2005). Absorbed energy was recorded to compute the impact strength of the specimen. The specimen before the test is shown in Figure 4.FindingsIn order to investigate two types of impact: drop-weight impact and Izod impact on damage resistance of composites, the two tests were done. Drop-weight impact is dropping a known weight and height in a vertical direction with free fall, absorbed energy can be calculated. Izod impact measures the energy required to break a specimen by striking a specific size bar with a pendulum (Test Method for Compressive, 2005; Test Methods for Determining, 2018). The results obtained with the impact test are presented. Figure 5 shows the histogram bars of impact strength of composites. It can be noticed that Kevlar–epoxy (KE) composites give higher energy strength than UHMWPE–epoxy (PE) in 12 and 20 plies. The increasing percentage is about 18.5 and 5.7%. It can be observed in Figure 6 that samples are not destructed completely due to fiber continuity. Also, the delamination occurs obviously for UHMWPE–epoxy more than for Kevlar-based composite, which may due to weak binding between UHMWPE with an epoxy relative with Kevlar.Practical implicationsThe force–time curves for Kevlar–epoxy (KE) and UHMWPE–epoxy (PE) composites with 12 and 20 plies are illustrated respectively in Figure 7. The contact duration between indenter and composite surface is repented by the force–time curves, so the maximum force reaches with certain displacement. It can be seen that maximum force was (13,209, 18,734.9, 23,271.07 and 19,825.38 N) at the time (3.97, 4.43, 3.791 and 4.198 ms) for 12 KE, 12 PE, 20 KE and 20 PE, respectively. The sharp peaks of KE composite are due to the lower ductility of Kevlar compared with UHMWPE. These results agree with the results of Ahmed et al. (2016). Kevlar-based composites (KE) showed lower impact force and crack propagates in the matrix with fast fiber breakage compared with PE composites, whereas the latter did not suffer from fabric breakage in 12 and 20 plies any more (see Figure 8). Figure 9 illustrates force–deformation curves, for 12 and 20 plies of Kevlar–epoxy (KE) and UHMWPE–epoxy (PE) composites. Curve's slop is considered the specimen's stiffness and the maximum displacement. To investigate the impact behavior of the four different composites, the comparison was made among the relative force–deformation curves. The maximum displacement was 5.119, 3.443, 1.173 and 1.17 mm for 12KE, 12 PE, 20 KE and 20 PE, respectively. It seems that UHMWPE-based composite (PE) presents lower deformation than Kevlar-based composites (KE) at a same number of laminates, although the maximum displacement is for 12 PE and 12 KE (see Figure 8). Kevlar-based composites (KE) showed more damage than UHMWPE-based composite (PE), so the maximum displacement is always higher for KE specimens with maximum indenter trace diameter (D∼11.27 mm). The onset of cracks begins along fibers on the impacted side for 20 KE and 20 PE specimens with lower indenter trace (D∼5.42 and 5.96 mm), respectively (see Table 2). These results refer to the lower stiffness of KE composites (see the slope of the curve) relative to PE composites. This result agreed with (Vieille et al., 2013) when they found that the theoretical stiffness of laminated composite during drop-weight impact depends significantly on fiber nature (Fadhil, 2013). The matrix cracking is the first type of damage that may not change stiffness of composites overall. Material stiffness changes due to the stress concentration represented by matrix cracks, delamination and fiber breakage (Hancox, 2000). Briefly, the histogram (see Figure 10) showed that the best impact behavior was for 20 KE, highest impact force with lower deformation, indenter trace diameter and contact time. Absorbed energy–time and absorbed energy–deformation curves for composites are shown in Figures 11 and 12, respectively. The maximum absorbed energy was (36.313, 29.952, 9.783 and 6.928 J) for 12 KE, 12 PE, 20 KE and 20 PE, respectively. Test period time is only 8 ms, but the time in which composites reached maximum absorbed energy was (4.413, 3.636, 2.394 and 2.408 ms). The maximum absorbed energy was for 12 KE with lower rebound energy because part of kinetic energy transferred to potential energy kept in the composite as material damage (see Figures 3 and 4). This composite absorbs more energy as material damage which kept as potential energy. Whereas other composites 12 PE, 20 PE and 20 KE showed less damage, lower absorbed energy and higher rebound energy, which appeared in different peak behavior as the negative value of energy. Also from the absorbed energy–time curves, it had been noticed significantly the maximum contact time of indenter with composite was 4.413 ms for 12 KE, which exhibits higher deformation (5.119 mm), whereas other composites 12 PE, 20 KE and 20 PE showed less damage, contact time and deformation as (3.443, 1.173, 1.17 mm), respectively.Originality/valueThe main goal of the current study is to evaluate the performances of armor composite made off of Kevlar and UHMWPE fabrics reinforced epoxy thermosetting resin under the low-velocity impact. Several plates of composites were prepared by hand layup. Izod and drop-weight impact tests were facilitated to get an indication about the absorbed energy and strength of the armors.

This retrospective study aimed to assess the number, demographic and clinical characteristics of patients seeking treatment for eating disorders at a clinical service specialized in delivering enhanced cognitive behavior (CBT-E) before (01/01/2018 - 08/03/2020) and during (09/03/2020 - 31/12/2021) the coronavirus (COVID-19) pandemic. A larger number of adults than adolescents sought treatment both before (121 [66%] vs. 62 [44%]) and during the COVID-19 pandemic (108 [53%] vs. 95 [47%]) (chi-squared=6.66, p=0.010). However, the percentage of adolescents seeking treatment was higher in the pandemic than in pre-pandemic years (60.5% vs. 39.5%). On the contrary, the rate of adults with an age of ≥25 years was lower during the COVID-19 pandemic (chi-square=8.71, p=0.033). No significant difference was found in demographics, clinical characteristics, and DSM-5 diagnoses between patients seeking treatment before and during the COVID-19 pandemic. In conclusion, the results show a significant increase in adolescent patients seeking outpatient CBT-E during the COVID-19 pandemic.

Background: Hindfoot and ankle fusions are mechanically limiting procedures for patients. However, patient-reported outcomes of these procedures have not been well studied. This study assessed outcomes of hindfoot and ankle fusions by using Patient-Reported Outcome Measurement Information System (PROMIS) Physical Function (PF) and Pain Interference (PI) Computer Adaptive Tests (CATs). Methods: Between 2014 and 2018, 102 patients were prospectively enrolled after presenting to a tertiary care facility for ankle and hindfoot fusions, including tibiotalar, tibiotalocalcaneal, subtalar, and triple arthrodeses. Study participants completed preoperative and 12-month postoperative PF and PI CATs. The differences between mean 12-month postoperative and preoperative PROMIS PF and PI T scores were analyzed with paired t tests. The relationship between the 12-month PF and PI differences for the overall sample and patient factors was examined using multiple regression modeling. Results: The sample had mean age of 57.69 years; 48% were male, and 55% were obese. Patients who underwent ankle and hindfoot arthrodesis had statistically significant improvements from preoperative to 12 months postoperative in mean PF (36.26±7.85 vs 39.38±6.46, P = .03) and PI (61.07±7.75 vs 56.62±9.81, P = .02). Triple arthrodesis saw the greatest increases in physical function (▵PF = 7.22±7.31, P = .01) and reductions in pain (▵PI = –9.17±8.31, P = .01), achieving minimal clinically important difference (MCID). Patients who underwent tibiotalar fusion had significant improvement in physical function (▵PF = 4.18±5.68, P = .04) and pain reduction that approached statistical significance (▵PI = –6.24±8.50, P = .09), achieving MCID. Older age (≥60 years ) was associated with greater improvements in PF ( β = 0.20, P = .07) and PI ( β = –0.29, P = .04). Preoperative PF and PI T scores were significantly associated with the 12-month change in PF and PI T scores, respectively ( β = –0.74, P < .01; β = –0.61, P < .01). Conclusion: Hindfoot and ankle fusions are procedures with favorable patient outcomes leading to increased physical function and decreased pain at 12 months postoperation relative to preoperation. Level of Evidence: Level II, prospective comparative study.

The caprification practice has been used widely in fig cultivation because it affects the yield and quality of fig fruits, a phenomenon known as the ‘xenia effect’. The present study was conducted to investigate the effects of pollen sources on fruit sets and fruit quality in the ‘Bursa Siyahı’ fig cultivar in 2017 and 2018. The eleven male genotypes and five cultivars were used as pollen source. The findings obtained in the present study showed that pollen sources significantly affected fruit set, early fruiting rate, fruit size, ostiole width, skin and flesh thickness, titratable acidity (TA), pH, and soluble solids content (SSC). The fruit set ratio varied from 32.02% (‘16 03 06’) to 76.66% (‘16 08 07’), and fruit weight varied from 77.29 g (‘16 03 06’) to 106.88 g (‘16 00 01’) based on pollen sources. The ostiole diameter ranged from 3.84 mm (‘16 ZF 08’) to 7.67 mm (‘77 00 01’). The skin thickness ranged from 3.01 mm (‘Havran’) to 5.35 mm (‘16 00 01’). The principal component analysis was performed to distinguish the pollen sources for the ‘Bursa Siyahı’ cultivar. The analysis proposed that the most important factors affecting the fig quality can be reduced to five components. Fruit weight (0.958), skin thickness (0.810), flesh l* value (0.821), pH (-0.872), and SSC (0.836) value could be regarded as the characteristic indicators for PC1, PC2, PC3, PC4, and PC5, respectively. The results showed that ‘16 09 10’, ‘16 05 03’, ‘16 08 07’, and ‘16 08 12’ pollen sources are adequate pollinators for the edible ‘Bursa Siyahı’ fig.

Abstract. This study provides a detailed characterization of stratocumulus clearings off the US West Coast using remote sensing, reanalysis, and airborne in situ data. Ten years (2009–2018) of Geostationary Operational Environmental Satellite (GOES) imagery data are used to quantify the monthly frequency, growth rate of total area (GRArea), and dimensional characteristics of 306 total clearings. While there is interannual variability, the summer (winter) months experienced the most (least) clearing events, with the lowest cloud fractions being in close proximity to coastal topographical features along the central to northern coast of California, including especially just south of Cape Mendocino and Cape Blanco. From 09:00 to 18:00 (PST), the median length, width, and area of clearings increased from 680 to 1231, 193 to 443, and ∼67 000 to ∼250 000 km2, respectively. Machine learning was applied to identify the most influential factors governing the GRArea of clearings between 09:00 and 12:00 PST, which is the time frame of most rapid clearing expansion. The results from gradient-boosted regression tree (GBRT) modeling revealed that air temperature at 850 hPa (T850), specific humidity at 950 hPa (q950), sea surface temperature (SST), and anomaly in mean sea level pressure (MSLPanom) were probably most impactful in enhancing GRArea using two scoring schemes. Clearings have distinguishing features such as an enhanced Pacific high shifted more towards northern California, offshore air that is warm and dry, stronger coastal surface winds, enhanced lower-tropospheric static stability, and increased subsidence. Although clearings are associated obviously with reduced cloud fraction where they reside, the domain-averaged cloud albedo was actually slightly higher on clearing days as compared to non-clearing days. To validate speculated processes linking environmental parameters to clearing growth rates based on satellite and reanalysis data, airborne data from three case flights were examined. Measurements were compared on both sides of the clear–cloudy border of clearings at multiple altitudes in the boundary layer and free troposphere, with results helping to support links suggested by this study's model simulations. More specifically, airborne data revealed the influence of the coastal low-level jet and extensive horizontal shear at cloud-relevant altitudes that promoted mixing between clear and cloudy air. Vertical profile data provide support for warm and dry air in the free troposphere, additionally promoting expansion of clearings. Airborne data revealed greater evidence of sea salt in clouds on clearing days, pointing to a possible role for, or simply the presence of, this aerosol type in clearing areas coincident with stronger coastal winds.

Background Antipsychotic medications have limited benefits in schizophrenia, and cognitive behavioral therapy may be beneficial as an adjunct. There may be potential for implementing mobile cognitive behavioral therapy–based treatment for schizophrenia in addition to standard antipsychotic medications. Objective This study aims to determine whether PEAR-004, a smartphone-based investigational digital therapeutic, improves the symptoms of an acute psychotic exacerbation of schizophrenia when it is added to standard treatments. Methods This was a 12-week, multicenter, randomized, sham-controlled, rater-blinded, parallel group proof‑of‑concept study of 112 participants with moderate acute psychotic exacerbation in schizophrenia. This study was conducted in 6 clinical trial research sites in the United States from December 2018 to September 2019. The primary outcome, change in Positive and Negative Syndrome Scale (PANSS) from baseline to week 12 or the last available visit, was analyzed using the mixed-effects regression model for repeated measures, applied to an intent-to-treat sample. Results The total PANSS scores slightly decreased from baseline over the study period in both groups; the treatment difference at day 85 between PEAR-004 and sham was 2.7 points, in favor of the sham (2-sided P=.09). The secondary scales found no benefit, except for transient improvement in depressive symptoms with PEAR-004. Application engagement was good, and patient and clinical investigator satisfaction was high. No safety concerns were observed. There was some evidence of study site heterogeneity for the onboarding processes and directions on PEAR-004 product use at baseline and throughout the study. However, these differences did not affect the efficacy results. Conclusions In the largest-to-date randomized, sham-controlled study of a digital therapeutic in schizophrenia, PEAR-004 did not demonstrate an effect on the primary outcome—total PANSS scores—when compared with a nonspecific digital sham control. The secondary and exploratory results also did not demonstrate any notable benefits, except for possible temporary improvement in depressive symptoms. This study provided many useful scientific and operational insights that can be used in the further clinical development of PEAR-004 and other investigational digital therapeutics. Trial Registration ClinicalTrials.gov NCT03751280; https://clinicaltrials.gov/ct2/show/NCT03751280

Fine particulate matter (PM2.5) has attracted extensive attention due to its harmful effects on humans and the environment. The sparse ground-based air monitoring stations limit their application for scientific research, while aerosol optical depth (AOD) by remote sensing satellite technology retrieval can reflect air quality on a large scale and thus compensate for the shortcomings of ground-based measurements. In this study, the elaborate vertical-humidity method was used to estimate PM2.5 with the spatial resolution 1 km and the temporal resolution 1 hour. For vertical correction, the scale height of aerosols (Ha) was introduced based on the relationship between the visibility data and extinction coefficient of meteorological observations to correct the AOD of the Advance Himawari Imager (AHI) onboard the Himawari-8 satellite. The hygroscopic growth factor (f(RH)) was fitted site-by-site and month by month (1–12 months). Meanwhile, the spatial distribution of the fitted coefficients can be obtained by interpolation assuming that the aerosol properties vary smoothly on a regional scale. The inverse distance weighted (IDW) method was performed to construct the hygroscopic correction factor grid for humidity correction so as to estimate the PM2.5 concentrations in Sichuan and Chongqing from 09:00 to 16:00 in 2017–2018. The results indicate that the correlation between “dry” extinction coefficient and PM2.5 is slightly improved compared to the correlation between AOD and PM2.5, with r coefficient values increasing from 0.12–0.45 to 0.32–0.69. The r of hour-by-hour verification is between 0.69 and 0.85, and the accuracy of the afternoon is higher than that of the morning. Due to the missing rate of AOD in the southwest is very high, this study utilized inverse variance weighting (IVW) gap-filling method combine satellite estimation PM2.5 and the nested air-quality prediction modeling system (NAQPMS) simulation data to obtain the full-coverage hourly PM2.5 concentration and analyze a pollution process in the fall and winter.

ABSTRAK Penelitian ini bertujuan untuk menguji spillover effect indeks saham syariah Amerika Serikat dan Cina terhadap indeks saham syariah ASEAN dengan menggunakan metode Nonlinier Autoregressive Distributed Lag (NARDL) untuk menemukan spillover effect yang bersifat asimetris selama pandemi Covid-19. Data yang diamati dimulai pada 1 Januari 2020 sampai dengan 30 September 2021 dengan total observasi sebanyak 336 data untuk masing-masing indeks saham. Penelitian ini mendapatkan beberapa temuan. Pertama, indeks saham syariah Amerika Serikat dan Cina memiliki pengaruh asimetris jangka pendek terhadap indeks saham syariah Indonesia, Malaysia dan Thailand selama pandemi Covid-19. Kedua, indeks saham syariah Amerika Serikat dan Cina hanya memiliki pengaruh asimetris jangka panjang terhadap indeks saham syariah Malaysia selama pandemi Covid-19. Ketiga, efek ketika terjadi penurunan indeks saham syariah Amerika Serikat dan Cina lebih besar dibandingkan pada saat terjadi kenaikan terhadap indeks saham syariah Malaysia selama pandemi Covid-19. Salah satu penyebab hubungan tersebut adalah karena adanya hubungan dagang yang sangat erat antara Amerika Serikat dan Cina terhadap Malaysia. Adapun implikasi dari penelitian ini adalah investor internasional dapat menjadikan hasil penelitian ini sebagai bahan pengambilan keputusan apabila terjadi kontraksi akibat krisis seperti pada saat pandemi Covid-19 terhadap indeks saham syariah Amerika Serikat dan Cina untuk mempertahankan maupun menjual portofolio investasi mereka. Kata Kunci: Spillover, Indeks Syariah, Asimetris, Covid-19. ABSTRACT This study aims to examine the spillover effect of Islamic stock indexes of the United States and China on the ASEAN Islamic stock index using the Nonlinear Autoregressive Distributed Lag (NARDL) method to find asymmetric spillover effects during the Covid-19 pandemic. The observed data starts on January 1, 2020, until September 30, 2021, with a total of 336 observations for each stock index. This study found some findings. First, the Islamic stock indexes of the United States and China have a short-term asymmetric influence on the Islamic stock indices of Indonesia, Malaysia, and Thailand during the Covid-19 pandemic. Second, the Islamic stock indexes of the United States and China have only a long-term asymmetric influence on Malaysia's sharia stock indexes during the Covid-19 pandemic. Third, the effect when there is a decline in Islamic stock indexes of the United States and China is greater than when there is an increase in the Malaysian sharia stock index during the Covid-19 pandemic. One of the reasons for this relationship is the very close trade relationship between the United States and China with Malaysia. The research implication of this study is that international investors can use the results of this research as a decision-making material in the event of a contraction due to the crisis (one of which is the Covid-19 pandemic) in the United States and China Islamic stock indexes to maintain or sell their investment portfolios. Keywords: Spillover, Islamic Index, Asymmetric, Covid-19. DAFTAR PUSTAKA Abdullahi, S. I. (2021). Islamic equities and covid-19 pandemic: Measuring Islamic stock indices correlation and volatility in period of crisis. Islamic Economic Studies, 29(1), 50-66. https://doi.org/10.1108/IES-09-2020-0037 Aslam, F., Mohmand, Y. 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The pandemic of COVID-19 has afflicted every individual and has initiated a cascade of directly or indirectly involved events in precipitating mental health issues. The human species is a wanderer and hunter-gatherer by nature, and physical social distancing and nationwide lockdown have confined an individual to physical isolation. The present review article was conceived to address psychosocial and other issues and their aetiology related to the current pandemic of COVID-19. The elderly age group has most suffered the wrath of SARS-CoV-2, and social isolation as a preventive measure may further induce mental health issues. Animal model studies have demonstrated an inappropriate interacting endogenous neurotransmitter milieu of dopamine, serotonin, glutamate, and opioids, induced by social isolation that could probably lead to observable phenomena of deviant psychosocial behavior. Conflicting and manipulated information related to COVID-19 on social media has also been recognized as a global threat. Psychological stress during the current pandemic in frontline health care workers, migrant workers, children, and adolescents is also a serious concern. Mental health issues in the current situation could also be induced by being quarantined, uncertainty in business, jobs, economy, hampered academic activities, increased screen time on social media, and domestic violence incidences. The gravity of mental health issues associated with the pandemic of COVID-19 should be identified at the earliest. Mental health organization dedicated to current and future pandemics should be established along with Government policies addressing psychological issues to prevent and treat mental health issues need to be developed. References World Health Organization (WHO) Coronavirus Disease (COVID-19) Dashboard. 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A new fluorimetric and colorimetric dual-mode probe, 4-bromo-2-(hydrazonomethyl) phenol (BHP) has been synthesized and successfully utilized for the recognition of Cd2+/F‒ ions in DMSO/H2O (9:1, v/v) system. The probe displays dual channel of detection via fluorescence enhancement and colorimetric changes upon binding with F‒ and Cd2+ ions respectively. The Job’s plot analysis, ESI-MS studies, Density Functional Theoretical (DFT) calculations, 1H NMR and 19F NMR titration results were confirmed and highly supported the 1:1 binding stoichiometry of the probe was complexed with Cd2+/F‒ ions. Furthermore, intracellular detection of F‒ ions in HeLa cells and fluorescence imaging analysis in Zebrafish embryos results of the probe BHP might be used to reveal their potential applications in a biological living system. Introduction The quantification and detection of toxic metal ions in diverse fields have fascinated more attention in recent years due to their prominent and significant roles in clinical diagnosis and ecological system.1–6 Besides metal ions, anions also play an exclusive role in a variety of chemical and biological processes.7–12 In earlier, analytical methods for the detection of cations/anions has required highly sophisticated and expensive instruments such as atomic absorption spectrometry, inductively coupled plasma mass spectrometry, ion sensitive electrodes, and gas and ion chromatography. Amid, fluorescent techniques have more expedient in terms of rapidness, excellent sensitivity and selectivity, low cost, easy and feasible detection. In addition, optical detection mode analysis is a more appropriate method because of their potential features such as easy handling, real-time analysis and different signal output modes.13–16 Besides, colorimetric assays are more feasible and potent tool as they provide a simple visible authentication for analyte detection in the absence of instruments and tedious techniques. In this perspective, the recent research area has been mainly focused to design the novel multi-functional fluorometric and colorimetric sensors for the detection of ions in the different environments. Cadmium (Cd2+) is one of the important hazardous heavy transition metal ions17 in the environment due its carcinogenic nature. The higher accumulation of Cd2+ ion and inhalation of Cd-dust prompts more awful health issues in human like cancer, cardiovascular diseases, kidneys and liver damage.18 Furthermore, the Cd2+ ion has more advantages in several industries such as pigments in plastics, electroplating and batteries, etc. On the other hand, fluoride ions play an ample role in dental health and in the treatment of osteoporosis.19–22 The excess of fluoride ingestion prompted severe disease in human health like gastric and kidney problems.23 In some remote areas, the high level contamination of fluoride ions in drinking water triggered bone disease such as fluorosis.24–31 Thus, to develop and synthesize novel multifunctional probe for the detection and quantification of both cations and anions is a highly anticipated and imperative task. Scheme 1. Synthesis of probe BHP Herein, we have fabricated and synthesized a novel chromogenic and fluorogenic assay based on bromo substituted salicylhydrazone moiety for the colorimetric and fluorometric detection of F‒ ions and colorimetric detection of Cd2+ ions in DMSO/H2O (9:1, v/v) system. The UV-visible and fluorescence spectral analysis of BHP with Cd2+/F‒ ions exposed an outstanding ratiometric absorbance and colorimetric responses towards F‒ ions and also showed a visible colorimetric response towards Cd2+ ions. The fluorescence enhancement of BHP with F‒ ion was highly evaluated by DFT calculations. As well, the cell viability experimental results of BHP can be used for the detection of F‒ ions in both HeLa cells and Zebrafish embryos via high content analysis system. Experimental Methods 2.1 Materials All the chemicals used in the present study were in the analytical reagent grade and solvents used were of HPLC grade. Reagents were used as such received without any further purification. Metal ions such as K+, Na+, Ca2+, Mg2+, Fe2+, Fe3+, Ag+, Zn2+, Mn2+, Cu2+, Co2+, Ni2+, Cd2+, Al3+, Cr3+, Pb2+ and Hg2+ were purchased from Merck and S.D. Fine chemicals. The anions of Cl-, Br-, I-, SCN-, CN-, H2PO4-, HSO4-, NO3-, AcO- and F- were purchased as their tetrabutylammonium salts from Sigma–Aldrich Pvt. Ltd. Absorption measurements were performed on JASCO V-630 spectrophotometer in 1 cm path length quartz cuvette with a volume of 2 mL at room temperature. Fluorescence measurements were made on a JASCO and F- 4500 Hitachi Spectrofluorimeter with excitation slit set at 5.0 nm band pass and emission at 5.0 nm band pass in 1 cm ×1 cm quartz cell. 1H and 13C NMR spectra were obtained on a Bruker 300 MHz NMR instrument with TMS as internal reference using DMSO-d6 as solvent. Standard Bruker software was used throughout. 19F NMR spectra were recorded at 293K on BRUKER 400 MHz FT-NMR spectrometers using DMSO-d6 as solvent. ElectroSpray Ionisation Mass Spectrometry (ESI-MS) analysis was performed in the positive/negative ion mode on a liquid chromatography-ion trap mass spectrometer (LCQ Fleet, Thermo Fisher Instruments Limited, US). Fluorescence microscopic imaging measurements were determined using Operetta High Content Imaging System (PerkinElmer, US) 2.2. Synthesis of (E)-4-bromo-2-(hydrazonomethyl) phenol, BHP An absolute alcoholic solution (50 ml) of 5-bromosalicylaldehyde (0.5gm, 2.49 mmol) was refluxed under hydrazine hydrate (in excess) for 5 hr and the pale yellow color solid product was collected after recrystallized with ethanol and ethyl acetate mixture (yield, 95 %). 1H NMR (300 MHz, DMSO-d6) δ (ppm): 8.92 (s, 1H), 11.89 (s, 1H), 7.53 (d, J = 8.7 Hz, 1H), 6.94 (d, J = 5.8 Hz, 1H); 13C NMR (75 MHz, DMSO-d6) δ (ppm): 161.36, 158.51, 135.84, 131.82, 120.86, 119.69, 106.72. 2.3 Photophysical analysis of BHP The optical mode analysis of BHP towards various cations/anions in DMSO/H2O (9:1, v/v) system was carried out by using absorbance and fluorescence spectroscopy. UV-visible and fluorescence analysis of BHP with cations were gauged by using their corresponding acetate salts of metal ions. Tetrabutylammonium salts of competing anions were used for the anionic sensing analysis. 2.4 Computational Studies The optimized geometrical and ground state energy level calculations of BHP were obtained by Density functional theoretical (DFT) calculations were executed using Gaussian 09 program 32 with the 6-311G basis set. The optimized geometries and the fluorescence enhancement of probe BHP complexed with Cd2+/F- ions were attained by DFT-B3LYP level theory using 6-311G and LANL2DZ basis sets. 2.5 Cytotoxicity studies HeLa cell lines were procured from the National Center for Cell Science (NCCS), Pune, India. Cell lines are kept in the Dulbecco's Modified Eagle's medium (DMEM) supplemented with 10% fetal bovine serum (FBS), 1% antimycotic and antibiotic solution was used in this study. The cells were kept in an incubator at 25 °C with humidified atmosphere comprising 5% of CO2 and 95% of air. HeLa cells were loaded over the wells of 96 well-culture plates with a density of 1 x 104 cells/well. After 48 h of incubation, previous DMEM medium was exchanged with new medium and BHP (dissolved in DMSO) was added in the range of 0-200 µM to all the wells and further incubated over 3h. Cytotoxicity of BHP was measured by using MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay. After incubation of HeLa cells with BHP, the medium was detached. Further, 100 μl of DMSO was added and the resulting formazan crystals were dissolved in DMSO. The cell viability was determined by measuring the absorbance of each well at 540-660 nm (formation of formazan) using a microplate reader. 2.6 In vivo fluorescence analysis in Zebrafish embryos The fluorescence imaging analysis was performed in four days old embryos. The embryos were seeded over F- ion alone for 2 h in the E3 medium. The E3 medium was prepared by dissolving 5.0 mM NaCl, 0.17mM KCl, 0.33mM CaCl2, 0.33mM MgSO4 ingredients in H2O (2L) and the pH 7.2 was adjusted by adding NaOH. The embryos were thoroughly washed with E3 medium. Successively, incubated embryos were sowed over 25 mM of BHP (in DMSO) solution for 3h. Further, embryos were washed again with E3 medium and fixed in 10% methyl cellulose solution for the good oriented images. The fluorescent images of BHP-F- were logged using high content screening microscopy. (Excitation wavelength of 482 nm and emission wavelength range of 500-700 nm). Results and discussion The probe, (E)-4-bromo-2-(hydrazonomethyl) phenol (BHP) has been synthesized by one step condensation between hydrazine and 5-bromosalicylaldehyde in ethanol (yield, 95 %) as shown in Scheme 1. The structure of the probe BHP was confirmed via 1H, 13C NMR analysis (Figure S1-S2, See ESI) 3.1. UV–vis spectral analysis of cations with BHP To investigate the cation sensing events of BHP towards different cations in DMSO/H2O (9:1, v/v) system by using UV-vis and fluorescence titration experiments. Initially, free probe BHP exhibited an absorption band at 367 nm and further addition of mono, di and trivalent cations such as Li+, K+, Ag+, Mn2+, Co2+, Ni2+, Cu2+, Zn2+, Fe2+, Hg2+, Na+, Mg2+, Ca2+, Pb2+, Fe3+ and Cr3+ exhibited tiny changes in absorption spectr due to their weak interaction towards BHP except Cd2+ ion as shown in Figure 1. Interestingly, upon titrated with Cd2+ ion, a new absorption band appeared at 470 nm due to the highly resonance induced charge transfer ability of bromo substituted salicyl moiety while the solution turns into dark yellow color from pale yellow. Increasing addition of Cd2+ ion results gradual reduction of both higher and lower energy bands at 367 nm and 470 nm respectively as depicted in Figure 2. Figure 1. UV-vis spectra of BHP (10 µM) with different cations (5 × 10-3 M) in DMSO/H2O (9: 1, v/v) system. Figure 2. UV-vis spectra of BHP (10 µM) with Cd2+ (0 – 100 µM) in DMSO/H2O (9: 1, v/v) system Besides, fluorescence response of probe BHP towards various cations such as Li+, K+, Ag+, Mn2+, Co2+, Ni2+, Cu2+, Zn2+, Fe2+, Hg2+, Na+, Mg2+, Ca2+, Pb2+, Fe3+ and Cr3+ including Cd2+ ion have been inspected in DMSO/H2O (9:1, v/v) system. Initially, the probe BHP displayed low intensed fluorescence band in free state. Addition of other commonly coexistent metal ions including Cd2+ ions exhibited trivial changes in fluorescence spectra. From these results, it is concluded that the probe BHP could serve as an excellent colorimetric assay for the detection of Cd2+ ions. 3.2. The sensing analysis of BHP towards anions Moreover, the anion binding attraction of BHP towards anions have been investigated in DMSO/H2O (9:1, v/v) system via both UV-visible and fluorescence spectral techniques. Initially the probe BHP showed the absorption band at 367 nm. Upon titrated with other anions such as Cl‒, Br‒, I‒, NO3‒, AcO‒, HSO4‒, H2PO4‒ and CN‒ were failed to alter the absorbance of the probe BHP except F‒ ions as shown in Figure 3a. Moreover, the incremental addition of F‒ ions (0-50 µM), the higher energy band at 367 nm was decreased along with the increment in new absorption band at 482 nm results an excellent ratiometric response. The new low energy band observed at 482 nm due to the deprotonation of–OH group present in salicyl moiety initiated by hydrogen bonding [Figure 3b]. At that affair, the solution turns into orange color from pale yellow and it was simply discerned by naked eye [Figure 4]. Besides, under identical condition, the fluorescence titration experiment of BHP was carried out in the presence of different anions. Interestingly, the probe BHP displayed low intensed fluorescence band at 601 nm and the other competing anions were failed to affect the fluorescence intensity except F‒ ions as shown in [Figure 5a]. Further, the incremental addition of F‒ ions triggers the enhancement in intensity results an excellent “turn on” fluorescence response due to the deprotonation and the inhibition of charge transfer state stimulated by resonance around the moiety [Figure 5b]. 3.3. Competitive experiments To gauge the selectivity and recognizing ability of BHP, competitive analysis was performed in the presence of varying concentration of F‒ ion (0-50 µM). Initially, the probe was treated with 5 × 10-3 M of different anions such as, CN-, I-, Br-, Cl-, NO2-, CH3COO-, H2PO4- and HSO4-. The other common competing anions were failed to bind with the probe BHP except F- ion [Figure 6 (a) and (b)]. From these observations, it is ensured that BHP could act as an excellent selective and sensitve chromogenic receptor for F- ions in real time monitoring and different biological applications. Figure 3 (a): UV-vis spectra of BHP with 5 × 10-3 M of other anions in DMSO/H2O (9: 1 v/v) system. (b) UV-visible spectra of BHP (5 µM) with F‒ (0-50 µM) in DMSO/H2O (9: 1 v/v) system. Figure 4. Naked eye detection of F‒ ions with BHP under visible light (top) and UV-lamp (bottom) and BHP with Cd2+ visible light only (bottom). Figure 5 (a): Fluorescence spectra of BHP (5µM) with 5 × 10-3 M of other anions in DMSO/H2O (9: 1, v/v) system. Excitation at 482 nm. Slit width is 5 nm. (b) Fluorescence spectra of BHP (5µM) with F‒ (0-50 µM) in DMSO/H2O (9: 1, v/v) system. Excitation at 482 nm. Slit width is 5 nm. Figure 6 (a): Selectivity analysis of F‒ ion with BHP in the presence of competing anions. Excitation at 480 nm, Slit width = 5 nm. (b) The blue bars represent the change of the fluorescence intensity of BHP with the consequent addition of other anions. The pink bars represent the addition of the competing anions to BHP. Excitation at 480 nm, Slit width = 5 nm. 3.4. Job’s plot analysis and calculation of binding constant of BHP for Cd2+/F‒ ions Furthermore, the Job’s plot [Figure 7(a) and (b)] analysis based on UV-visible and fluorescence titration experiments results confirmed the 1:1 binding stoichiometry of BHP with both Cd2+/F‒ ions respectively. To further support the binding stoichiometry of BHP with Cd2+/F‒ions, ESI-MS spectral analysis were performed. The ESI-MS spectral analysis of BHP-Cd2+/BHP-F‒ disclosed peaks at 327.45/258.28 corresponds to [BHP+Cd2++Na+]/[BHP+F‒+H++Na+] respectively (Figure S3-S4, See ESI). Furthermore, the 1:1 binding stoichiometry of BHP with F− ions was confirmed via 1H NMR titration profile (Figure 8) and 19F NMR. The deprotonation of ‒OH group present in the salicyl moiety was initiated by hydrogen bonding and the plausible binding mode of BHP with Cd2+ and F‒ ion is shown in Scheme 2. Further, the absorbance and fluorescence intensity changes of Cd2+ ions (A472 nm) and F‒ ions (A482 nm, I603 nm) were plotted against [Cd2+] and [F‒] respectively provided a good linear relationship between both BHP and Cd2+/F‒ ions (Figure S5, S6 and S7, See ESI). From absorbance and fluorescence titration profile, the binding constant values of BHP for Cd2+/F‒ ions were calculated using modified Benesi-Hildebrand method ions (Figure S8, S9 and S10, See ESI). The binding constant values of BHP with Cd2+ ions were found to be 4.26 ×10-4 M from UV-visible titration profile. Similarly, the binding constant values of BHP with F‒ ions were estimated to be 6.03 ×10-3 M / and 3.01 × 10-4 M from UV-visible and fluorescence titration profile respectively. The detection limits (LOD) of F‒ were calculated to be 0.05 nM respectively. Moreover, the LOD values of BHP signifies that the probe might be utilized for the quantitative determination of F‒ ions in environment and real system. Figure 7 (a) Job’s plot for BHP with F‒ ion. (b) Job’s plot for BHP with Cd2+ ion Scheme 2. Binding mode of BHP with Cd2+/F‒ ions 3.5. 1H NMR titrations of BHP with F- ions In addition, to confirm and highly supported the 1:1 binding stoichiometry of probe with F- ions, 1H NMR titrations was performed. Upon addition of F- ion (0.5 equiv), the proton signal corresponds to phenolic –OH group at 11.14 ppm was gradually decreased. Further, addition of 1 equiv. of F- ions to BHP showed the complete disappearance of –OH proton signal as depicted in Figure 8. Moreover, the binding stoichiometric ratio of F- ion with BHP was further supported by 19F NMR experiment. The (H2F)- signal appeared at -124.33 ppm (Figure S11-S12, See ESI) confirms the deprotonation process arose from phenolic –OH proton. Figure 8 1H NMR titration of BHP with F- (0-1equiv) in DMSO-d6 3.6. DFT calculations of BHP with Cd2+/F- ion To recognize the fluorescence enhancement of probe BHP after complexation with F-, DFT calculations were accomplished. The optimized structures of BHP, BHP-Cd2+ and BHP-F- were obtained using DFT/B3LYP-6-311G and B3LYP/LanL2DZ basis sets respectively. The frontier molecular orbital diagram obtained from optimized structure of BHP is presented in Figure 9. Upon binding with Cd2+ ion, the HOMO and LUMO are delocalized over the entire salicyl unit and their energy gap was reduced. It is noteworthy that inhibition of charge transfer in probe BHP renders the reduction of absorbance at 367 nm and 470 nm. Moreover, Complexation of F- ion to the probe BHP leads to lowering of HOMO-LUMO energy gap. In the presence of F-, HOMO and LUMO are distributed over the whole molecule of BHP. From these results, the F- ion was efficiently binded and complexed with BHP than Cd2+ ion. Figure 9. Frontier molecular orbital diagram of BHP, BHP-Cd2+and BHP-F‒ 3.7. Live cell Imaging analysis of BHP in HeLa cells / Zebrafish embryos The cell viability or cytotoxicity analysis of BHP (0–200 µM) against Human HeLa cells were performed using MTT assay. In 100 µM of BHP, cell viability was obtained as too high as 98%. (Figure S13, See ESI). Hence, the probe was sucessfully used for live cell imaging analysis of F- ions in Figure 10. Live cell fluorescence imaging analysis of BHP in HeLa cells. (a) Bright field images of HeLa cells incubated with BHP (25 µM) for 3h (b) Fluorescence merged images of HeLa cells incubated with BHP (25 µM) (c) Fluorescence image of HeLa cells incubated with BHP (25 µM) alone (d) Fluorescence image of HeLa cells incubated with BHP (25 µM) and 25 µM of F‒ ions for 1 h HeLa cells. Further, the HeLa cells were pre-treated with 25 µM of BHP alone for 3 h. Then HeLa cells were seaded with 25 µM of F- ions for 1h. In the absence of F- ions, the probe BHP exposed a weak yellow fluorescence. However, addition of F- ions to the probe BHP induced a bright orange fluorescence (Figure 10). These results endorsed that the probe BHP can be successfully utilized for the intracellular fluorescence imaging analysis of F- ions in HeLa cells. Besides, the exceptional cell viability output of BHP has been further explored in four days Zebrafish embryos. Zebrafish has positioned as a well-known vertebrate model in numerous biological applications. From this perspective, we have utilized also zebrafish embryos as a living animal model to expose the excellent imaging potential of BHP for the detection of F‒ ion in the biological environment (Figure 11) . Figure 11. Fluorescence imaging analysis of F‒ ion in 4 days old Zebrafish embryos developed with BHP and various concentrations of F‒ ion (a) bright field images of BHP (25 µM) alone, (b) fluorescence merged images of BHP and F- ion (25 µM) (c) fluorescence image of BHP (25 µM) alone (d) 25 µM of F‒ ion for 2 h continuously incubated with BHP (25 µM) for 3 h. 3.8. Evaluation of BHP with previous reports The probe BHP has valid and multi features such as single step synthesis, dual-mode recognition, turn-on fluorescence response and colorimetric change. The probe BHP displayed unique sensing property among other dual sensors. Table S1 compares the sensing performance of BHP with recently reported F‒ receptors. Amid, BHP exhibits too low limit of detection when compared with other previously reported chemoreceptors cited in table S1. Also, the limit of detection of BHP is within the range of recommended limits set by both EPA and WHO for F‒ Ions. Moreover, the fluorescence imaging experiments inferred that the probe BHP can be utilized as potential tool for mapping F‒ ion distribution in HeLa cells and Zebrafish embryos. Conclusions We have designed and synthesized a new chromogenic and fluorogenic probe based on salicylhydrazone derivative for the selective and sensitive detection of both Cd2+/F- ions by colorimetrically and fluorimetrically respectively. As per our knowledge, it is a novel simple hydrazone receptor for sensing carcinogenic heavy metal Cd2+ via colorimetric method and biologically significant F‒ ion by both colorimetric and fluorimetric methods. The binding constant value of Cd2+ ion was found to be 4.26×10-4 M by UV-visible method where as 6.03×10-3 and 3.01×10-4 M for F- ion by both UV-visible and fluorescence methods respectively. The limit of detection was found to be 0.05 nM for F- ion. The excellent biological potential of BHP has been successfully utilized for the detection of F- ions in Zebrafish embryos and human HeLa cells. Acknowledgments The authors acknowledge the financial support from the Council of Scientific and Industrial Research, Extramural Research, New Delhi, India (Grant No. 01(2901)17/EMR-II. The Department of Science and Technology, SERB, Extramural Major Research Project (Grant No. EMR/2015/000969), Department of Science and Technology, CERI, New Delhi, India (Grant No. DST/TM/CERI/C130(G) and we acknowledge the DST-FIST, DST-PURSE,DST-IRPHA, UPE programme and UGC-NRCBS, SBS, MKU for providing instrumentation facilities. References Jäkle, F. Chem. Rev. 2010, 110, 3985. 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Local sites and practices of information work become embroiled in the larger imperatives and logics of the global knowledge economy through social, technological, and spatial networks. Drawing on human geography’s central claim that space and time are dialectically produced through social practices, in this essay I use human/critical geography as a framework to situate the processes and practices—the space and time—of information literacy within the broader social, political, and economic environments of the global knowledge economy. As skills training for the knowledge economy, information literacy lies at the intersection of the spatial and temporal spheres of higher education as the locus of human capital production. Information literacy emerges as a priority for academic librarians in the 1980s in the context of neoliberal reforms to higher education: a necessary skill in the burgeoning “information economy,” it legitimates the role of librarians as teachers. As a strategic priority, information literacy serves to demonstrate the library’s value within the university’s globalizing agenda. While there has been a renewed interest in space/time within the humanities and social sciences since the 1980s, LIS has not taken up this “spatial turn” with the same enthusiasm—or the same degree of criticality—as other social science disciplines. This article attempts to address that gap and offers new insights into the ways that the spatial and temporal registers of the global knowledge economy and the neoliberal university produce and regulate the practice of information literacy in the academic library. Pre-print first published online 12/09/2018

Tobacco (Nicotiana tabacum L.) is an important cash crop in China, with an estimated production of 2.2 million tons every year (Berbeć and Matyka, 2020). In June 2020, a root rot disease was observed on tobacco (cv. Zhongyan 100) in four surveyed counties (Mianchi, Lushi, Duguan and Lingbao) in Sanmenxia. Diseased plants exhibited leaf chlorosis and purplish to brown vascular discoloration of stem, taproot and lateral roots. The disease incidence ranged from 15% to 40% in 11 surveyed fields, 36.7 ha in total. Twenty five diseased tissues were surface sterilized in 75% ethanol and placed on potato dextrose agar (PDA) medium. Fifteen single-spore isolates were obtained from 25 diseased tissue samples. All cultures growing on PDA had white colonies with abundant aerial mycelia initially, turning into yellow to orange in the center and produced red pigmentation after seven days of growth. The 7-day-old cultures grown on carnation leaf agar (CLA) produced macroconidia that were curved with 3-5 septa, had wide central cells, slightly pointy apex, and measured 17.0-45.9 μm long×3.0-4.6 μm wide (n=50). The microconidia formed on CLA were slightly curved, ovoid with zero to two septa, measuring 5.4-15.5 μm long×2.0-3.2 μm wide (n=50). Spherical chlamydospores (7.58-13.52 μm; n=50) were terminal or intercalary, single or in chains. Such characteristics were typical of Fuarium brachygibbosum (Tirado-Ramírez et al. 2018). DNA from one representative single-spore isolate (MC1) was extracted, and the translation elongation factor 1-alpha (EF1-α), RNA polymerase I largest subunit (RPB1) and second largest subunit (RPB2) genes were amplified with primers EF1/EF2, F5/G2R and RPB2F/R respectively (O’Donnell et al. 1998, 2010), and sequenced. Sequences were submitted to GenBank under accession numbers MT947796 (EF1-α), MW679536 (RPB1) and MW430664 (RPB2). The consensus sequences showed 99.70%, 99.94% and 100% identity to the sequences of F. brachygibbosum strain NRRL 34033 (accession no. GQ505418.1, HM347172.1 and GQ505482.1, Wang et al 2021). Morphological and molecular results confirmed this species as F. brachygibbosum (Al-Mahmooli, et al., 2013, Rentería -Martínez, et al., 2018). Pathogenicity tests were performed on tobacco seedlings grown on autoclaved tobacco specific substrate (Tobacco specific matrix, Ainong Biotechnology Co. Ltd, China). Healthy six-leaf stage tobacco seedlings (n=30; Zhongyan 100) were inoculated by placing 7-days old wheat seed (15 seeds per plant) infested with MC1 around the root. Thirty seedlings inoculated with sterile wheat seeds served as controls. All the plants were maintained in a growth chamber at 25±0.5℃ and 70% relative humidity. The assay was conducted three times. Typical symptoms of foliage chlorosis and root browning were observed 7-14 days after inoculation. The pathogen was reisolated from the necrotic tissue from all inoculated seedlings and was identified by sequencing partial EF1-α and RPB2 genes. Control plants remained asymptomatic and no pathogen was recovered from the control plants. Fusarium brachygibbosum is known as a pathogen of grains and cash crops in China (Shan, et al., 2017, Xia, et al., 2018). To our knowledge, this is the first report of F. brachygibbosum causing root rot on tobacco. We believe that our results will help to better understand rhizome fungal diseases affecting tobacco production in China. Acknowledgements: Funding was provided by the Science and Technology Project of Henan Provincial Tobacco Company (2020410000270012), Independent Innovation Project of Hennan Academy of Agricultural Sciences (2020ZC18) and Research and Development project of Henan Academy of Agricultural Sciences (2020CY010). References: Al-Mahmooli, I. H., et al. 2013. Plant Dis. 97:687; https://doi.org/10.1094/PDIS-09-12-0828-PDN Berbeć A. K. and Matyka M. 2020. Agric. 10(11), 551; https://doi.org/10.3390/agriculture10110551 O’Donnell, K., et al. 1998. P. Natl. Acad. Sci. USA. 95(5):2044-2049; https://doi.org/10.1073/pnas.95.5.2044 O’Donnell, K., et al. 2010. J. Clin. Microbiol. 48(10)3708-3718; https://doi.org/10.1128/JCM.00989-10 Rentería -Martínez M.E., et al. 2018. Mex. J. of Phytopathol. 36(2):1-23; https://doi.org/10.18781/R.MEX.FIT.1710-1 Shan, L. Y., et al. 2017. Plant Dis. 101:837; https://doi.org/10.1094/PDIS-10-16-1465-PDN Tirado-Ramírez, M. A., et al. 2018. Plant Dis. 103; https://doi.org/10.1094/PDIS-04-18-0710-PDN Wang, S., et al. 2021. Plant Dis. 2021 Jan 6. doi: 10.1094/PDIS-05-20-0941-PDN. Epub ahead of print. PMID: 33406862. Xia, B., et al. 2018. Plant Dis. 102(11):2372; https://doi.org/10.1094/PDIS-12-17-1939-PDN The author(s) declare no conflict of interest.

Vietnam National University, Hanoi has been assigned important tasks of producing high quality human resources and cultivating talents; promoting advanced science, technology, renovation and multidisciplinary knowledge transfer by the government of Vietnam. In terms of scientific research, PhD students have contributed significantly to the overall achivements of Vietnam National University, Hanoi. The authors survey 263 out of 1493 PhD students (acounting for 17.6%) who are studying in five academic fields of Vietnam National University, Hanoi. The article presents the current status of supporting scientific research activities for PhD students, particularly focuses on the support role of scientific working groups at Vietnam National University, Hanoi and proposes solutions to improve the quality of the support activities at Vietnam National University, Hanoi in the future. Keywords PhD support, Scientific research, Scientific working group References [1] Đại học Quốc gia Hà Nội, Quy chế đào tạo tiến sĩ tại Đại học Quốc gia Hà Nội ban hành theo Quyết định số 4555/QĐ-ĐHQGHN, ngày 24 tháng 11 năm 2017 của Giám đốc Đại học Quốc gia Hà NộI, 2017.[2] Đại học Quốc gia Hà Nội, Quy chế đào tạo sau đại học tại Đại học Quốc gia Hà Nội ban hành theo Quyết định số 1555/QĐ-ĐHQGHN, ngày 25 tháng 5 năm 2011 của Giám đốc Đại học Quốc gia Hà NộI, 2011.[3] Helen Walkington, Students as researchers: Supporting undergraduate research in the disciplines in higher education, York: The Higher Education Academy, ISBN 978-1-907207-86-0. https://www.heacademy.ac.uk/system/files/resources/Students%20as%20researchers_1.pdf/, 2015.[4] N. Perkins, Institute of Development Studies (IDS), at the seminar: “Research Communication - Why and how?”, University of Copenhagen, May 8, 2008.[5] Enyu Zhou, Hironao Okahana, The Role of Department Supports on Doctoral Completion and Time-to-Degree, Journal of College Student Retention: Research, Theory & Practice - ESCI (Emerging Sources Citation Index) ISSN15210251, 15414167, 2016.[6] Nickola C. Overall a, Kelsey L. Deane a, Elizabeth R. Peterson, Promoting doctoral students' research self-efficacy: combining academic guidance with autonomy support, Higher Education Research & Development, ISSN 07294360. https://www.researchgate.net/publication/231537782_Promoting_doctoral_students'_research_self-Efficacy_Combining_academic_guidance_with_autonomy_support/, 2011.[7] Hanover Research, Building a Culture of Research: Recommended Practices, Academy Administration Practice. https://www.hanoverresearch.com/media/Building-a-Culture-of-Research-Recommended-Practices.pdf/, 2014. [8] Nguyễn Đình Đức, Phát triển nhóm nghiên cứu trong trường đại học: Xu thế tất yếu. https://vov.vn/xa-hoi/phat-trien-nhom-nghien-cuu-trong-truong-dh-xu-the-tat-yeu-325151.vov/, 2014.[9] Nguyễn Thị Thu Hà, Bùi Minh Đức, Nguyễn Đình Đức, Một số nhân tố chủ yếu tác động đến hiệu quả hoạt động của các nhóm nghiên cứu, Tạp chí Khoa học Giáo dục, ĐHQGHN. 5(1) (2019) 54-63. https://doi.org/10.25073/2588-1159/vnuer.4214.[10] Nguyễn Lộc, Bất cập trong đào tạo sau đại học: Thừa tiến sĩ “giấy”, thiếu chất lượng. http://baokiemtoannhanuoc.vn/giao-duc/bat-cap-trong-dao-tao-sau-dai-hoc-thua-tien-si-giay-thieu-chat-luong-137700/, 2017. [11] Đặng Ứng Vận, Để đào tạo tiến sĩ thực chất hơn. http://www.nhandan.com.vn/cuoituan/item/33474402-de-dao-tao-tien-si-thuc-chat-hon.html/, 2017.[12] Nguyễn Đức Chính, Quản lý chất lượng giáo dục, NXB Đại học Quốc gia Hà Nội, 2017.[13] Đại học Quốc gia Hà Nội, Thống kê quy mô đào tạo năm học 2018 - 2019, 2018.[14] Đại học Quốc gia Hà Nội, Hướng dẫn thực hiện quy chế đào tạo tiến sĩ tại Đại học Quốc gia Hà Nội, số 123/HD-ĐHQGHN ngày 09/01/2018, 2018.[15] Đại học Quốc gia Hà Nội, Hướng dẫn đánh giá chất lượng thông qua phản hồi từ các bên liên quan, số 5077/HD-ĐHQGHN ngày 23/12/2014, 2014.

The reaction paths of the reaction of methyl radical with propanol-2 (i-C3H7OH) were investigated in detail using density functional theory at B3LYP/6-311++G(3df,2p) level. There were seven reaction pathways which form seven products including CH4 + (CH3)2COH, CH4 + (CH3)2CHO, CH4 + CH3CHOHCH2, CH3OH + CH3CHCH3, C2H6 + CH3CHOH, (CH3)2CH-O-CH3 + H and (CH3)3CH + OH. The results of analysis of the reaction paths and thermokinetic parameters showed that methane could be generated from three different channels. The removed H-atom from secondary carbon atom in the propanol-2 molecule is the most favorable of this reaction system. Keywords Methyl, propanol-2, B3LYP, transition state References [1] I. R. Slagle, D. Sarzyński, and D. Gutman, “Kinetics of the reaction between methyl radicals and oxygen atoms between 294 and 900 K,” Journal of Physical Chemistry, 1987.[2] L. Rutz, H. Bockhorn, and J. W. Bozzelli, “Methyl radical and shift reactions with aliphatic and aromatic hydrocarbons: Thermochemical properties, reaction paths and kinetic parameters,” in ACS Division of Fuel Chemistry, Preprints, 2004.[3] N. H. Tho and N. X. Sang, “Theoretical study of the addition and hydrogen abstraction reactions of methyl radical with formaldehyde and hydroxymethylene,” J. Serb. Chem. Soc.; OnLine First - OLF, 2018.[4] D. Ferro-Costas et al., “The Influence of Multiple Conformations and Paths on Rate Constants and Product Branching Ratios. Thermal Decomposition of 1-Propanol Radicals,” Journal of Physical Chemistry A, p. 4790−4800, 2018.[5] M. T. Holtzapple et al., “Biomass Conversion to Mixed Alcohol Fuels Using the MixAlco Process,” Applied Biochemistry and Biotechnology, 1999.[6] C. R. Shen and J. C. Liao, “Metabolic engineering of Escherichia coli for 1-butanol and 1-propanol production via the keto-acid pathways,” Metabolic Engineering, 2008.[7] A. Frassoldati et al., “An experimental and kinetic modeling study of n-propanol and iso-propanol combustion,” Combustion and Flame, vol. 157, pp. 2–16, 2010.[8] M. Z. Jacobson, “Effects of ethanol (E85) versus gasoline vehicles on cancer and mortality in the United States,” Environmental Science and Technology, 2007.[9] P. Gray and A. A. Herod, “Methyl radical reactions with ethanol and deuterated ethanols,” Transactions of the Faraday Society, 1968.[10] Z. F. Xu, J. Park, and M. C. Lin, “Thermal decomposition of ethanol. III. A computational study of the kinetics and mechanism for the CH3+C2H5OH reaction,” Journal of Chemical Physics, 2004.[11] N. H. Tho and D. T. Quang, “Nghiên cứu lý thuyết đường phản ứng của gốc metyl với etanol,” Vietnam Journal of Chemistry, vol. 56, no. 3, pp. 373–378, Jun. 2018.[12] N. H. Tho and N. X. Sang, “Kinetics of the Reaction of Methyl Radical with Methanol,” VNU Journal of Science: Natural Sciences and Technology; Vol 34 No 1DO - 10.25073/2588-1140/vnunst.4725 , Mar. 2018.[13] T. W. Shannon and A. G. Harrison, “The reaction of methyl radicals with methyl alcohol,” Canadian Journal of Chemistry, vol. 41, pp. 2455–2461, 1963.[14] S. L. Peukert and J. V. Michael, “High-temperature shock tube and modeling studies on the reactions of methanol with d-atoms and CH3-radicals,” Journal of Physical Chemistry A, 2013.[15] P. Gray and A. A. Herod, “Methyl radical reactions with isopropanol and methanol, their ethers and their deuterated derivatives,” Transactions of the Faraday Society, 1968.[16] A. D. Becke, “Density functional thermochemistry. I. The effect of the exchange only gradient correction,” Journal of Chemical Physics, vol. 96, p. 2155, 1992.[17] A. D. Becke, “Density-functional thermochemistry. II. The effect of the Perdew-Wang generalized-gradient correlation correction,” The Journal of Chemical Physics, vol. 97, p. 9173, 1992.[18] A. D. Becke, “Density-functional thermochemistry. III. The role of exact exchange,” The Journal of Chemical Physics, vol. 98, p. 5648, 1993.[19] W. Yang, R. G. Parr, and C. Lee, “Various functionals for the kinetic energy density of an atom or molecule,” Physical Review A, vol. 34 (6), pp. 4586–4590, 1986.[20] W. J. Hehre, L. Radom, P. V. R. Schleyer, and J. A. Pople, Ab Initio Molecular Orbital Theory. 1986.[21] M. P. Andersson and P. Uvdal, “New scale factors for harmonic vibrational frequencies using the B3LYP density functional method with the triple-zeta basis set 6-311+G(d,p).,” The journal of physical chemistry. A, vol. 109, pp. 2937–2941, 2005.[22] Frisch, M. J.; Trucks, G. W.; Schlegel, H.B.; Scuseria, G.E.; Robb, M.A.; Cheeseman, J. R., M. Scalmani, G.; Barone, V.; Mennucci, B.; Petersson, G. A.; Nakatsuji, H.; Caricato, J. L. Li, X.; Hratchian, H. P.; Izmaylov, A. F.; Bloino, J.; Zheng, G.; Sonnenberg, T. Hada, M.; Ehara, M.; Toyota, K.; Fukuda, R.; Hasegawa, J.; Ishida, M.; Nakajima, and Y. . et al. Honda, “Gaussian 09 Revision C.01, Gaussian Inc. Wallingford CT.,” Gaussian 09 Revision C.01. 2010.[23] G. Herzberg, Electronic Spectra and Electronic Structure of Polyatomic Molecules. 1966.[24] L. M. Sverdlov, M. A. Kovner, and E. P. Krainov, Vibrational spectra of polyatomic molecules. New York; Chichester; Jerusalem; London: Wiley ; Israel Program for Scientific Translations, 1974.[25] E. Hirota, “Anharmonic potential function and equilibrium structure of methane,” Journal of Molecular Spectroscopy, vol. 77, pp. 213–221, 1979.[26] P. Venkateswarlu and W. Gordy, “Methyl alcohol. II. Molecular structure,” The Journal of Chemical Physics, 1955.[27] E. . B. 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Abstract: This study aimed to establish a reasonable population pharmacokinetic model for rifampicin taken orally by patients with pulmonary tuberculosis, estimate pharmacokinetic parameters as well as influencing covariates. Blood samples of patients were collected at day 10 – 14 after commencing treatment. Time – concentration data were handled using non-linear mixed-effect model with Monolix 2018. An one-compartment, linear elimination, absorption with transit compartments model was found to be the most suitable for rifampicin. Volume of distribution (33,5 L) and clearance (9,62 L) were found to be influenced by fat-free mass (calculated using Janmahasatian’s method). Absorption-related parameters (Ktr, mean transit time and Ka) were found to have high inter-individual variability. Keywords Rifampicin, population pharmacokinetics, pulmonary tuberculosis. References [1] Christian Lienhardt et al, Target regimen profiles for treatment of tuberculosis: a WHO document (2017).[2] J.G. Pasipanodya et al, Serum drug concentrations predictive of pulmonary tuberculosis outcomes, The Journal of infectious diseases 208(9) (2013) 1464-1473. https://doi.org/10.1093/infdis/jit352[3] Jonathan Reynolds, Scott K Heysell (2014), Understanding pharmacokinetics to improve tuberculosis treatment outcome, Expert opinion on drug metabolism & toxicology 10(6) (2014) 813-823. https://doi.org/10.1517/17425255.2014.895813[4] E.F. Egelund, A.B. Barth, C.A. Peloquin (2011), Population pharmacokinetics and its role in anti-tuberculosis drug development and optimization of treatment, Current pharmaceutical design 17(27) (2017) 2889-2899. https://doi.org/10.2174/138161211797470246.[5] J.F. Murray, D.E. Schraufnagel, P.C. Hopewell, Treatment of tuberculosis. A historical perspective, Annals of the American Thoracic Society 12(12) (2015) 1749-1759. https://doi.org/10.1513/AnnalsATS.201509-632PS[6] K.E. Stott, et al, Pharmacokinetics of rifampicin in adult TB patients and healthy volunteers: a systematic review and meta-analysis, Journal of Antimicrobial Chemotherapy 73(9) (2018) 2305-2313. https://doi.org/10.1093/jac/dky152.[7] Le Thi Luyen, Ta Manh Hung et al, Simultaneous Determination of Pyrazinamide, Rifampicin, Ethambutol, Isoniazid and Acetyl Isoniazid in Human Plasma by LC-MS/MS Method, Journal of Applied Pharmaceutical Science 8(09) (2018) 061-073. https://doi.org/ 10.7324/JAPS.2018.8910.[8] M.T. Chirehwa et al, Model-based evaluation of higher doses of rifampin using a semimechanistic model incorporating autoinduction and saturation of hepatic extraction, Antimicrobial agents and chemotherapy 60(1) (2016) 487-494. https://doi.org/10.1128/AAC.01830-15.[9] Paolo Denti et al, A population pharmacokinetic model for rifampicin auto-induction, The 3rd international workshop on clinical pharmacology of TB drugs (2010).[10] Y. Jing et al, Population pharmacokinetics of rifampicin in Chinese patients with pulmonary tuberculosis, The Journal of Clinical Pharmacology 56(5) (2016) 622-627. https://doi.org/10.1002/jcph.643.[11] S.R.C. Milán et al, Population pharmacokinetics of rifampicin in Mexican patients with tuberculosis, Journal of clinical pharmacy and therapeutics 38(1) (2013) 56-61. https://doi.org/10.1111/jcpt.12016.[12] Anushka Naidoo et al, Effects of genetic variability on rifampicin and isoniazid pharmacokinetics in South African patients with recurrent tuberculosis, Pharmacogenomics(00) (2013). https://doi.org/10.2217/pgs-2018-0166.[13] Neesha Rockwood et al, HIV-1 coinfection does not reduce exposure to rifampin, isoniazid, and pyrazinamide in South African tuberculosis outpatients, Antimicrobial agents and chemotherapy 60(10) (2016) 6050-6059. https://doi.org/10.1128/AAC.00480-16.[14] Alessandro Schipani et al, A simultaneous population pharmacokinetic analysis of rifampicin in Malawian adults and children, British Journal of Clinical Pharmacology 81(4) (2016) 679-687. https://doi.org/10.1111/bcp.12848.[15] Kok-Yong Seng et al, Population pharmacokinetics of rifampicin and 25-deacetyl-rifampicin in healthy Asian adults, Journal of Antimicrobial Chemotherapy 70(12) (2015) 3298-3306. https://doi.org/10.1093/jac/dkv268.[16] J.J. Wilkins et al, Population pharmacokinetics of rifampin in pulmonary tuberculosis patients, including a semimechanistic model to describe variable absorption, Antimicrobial agents and chemotherapy 52(6) (2008)2138-2148. https://dx.doi.org/10.1128%2FAAC.00461-07.[17] Sylvain Goutelle et al, Population modeling and Monte Carlo simulation study of the pharmacokinetics and antituberculosis pharmacodynamics of rifampin in lungs, Antimicrobial agents and chemotherapy 53(7) (2009) 2974-2981. https://doi.org/10.1128/AAC.01520-08.[18] R.M. Savic et al, Implementation of a transit compartment model for describing drug absorption in pharmacokinetic studies, Journal of pharmacokinetics and pharmacodynamics 34(5) (2007) 711-726. https://doi.org/10.1007/s10928-007-9066-0.[19] B.J. Anderson, N.H.G. Holford, Mechanism-based concepts of size and maturity in pharmacokinetics, Annu. Rev. Pharmacol. Toxicol 48 (2008) 303-332. https://doi.org/10.1146/annurev.pharmtox.48.113006.094708.[20] Kok-Yong Seng et al, Population pharmacokinetic analysis of isoniazid, acetyl-isoniazid and isonicotinic acid in healthy volunteers, Antimicrobial agents and chemotherapy, pp. AAC. (2015) 01244-15. https://doi.org/10.1128/AAC.01244-15.[21] Sarayut Janmahasatian et al, Quantification of lean bodyweight, Clinical pharmacokinetics 44(10), (2005) 1051-1065. https://doi.org/10.2165/00003088-200544100-00004.[22] Kidola Jeremiah et al, Nutritional supplementation increases rifampin exposure among tuberculosis patients coinfected with HIV, Antimicrobial agents and chemotherapy 58(6) (2014) 3468-3474. https://doi.org/10.1128/AAC.02307-13

The geometries, stabilities of VGen0/- (n = 9 - 13) clusters were systematically studied by the density functional theory (DFT) using the BP86 functional and LANL2DZ basis set. Several possible multiplicities of each cluster were tested to determine the most stable structure among the isomers. The average binding energy per atom, fragmentation energy, second order energy difference and HOMO-LUMO gaps were evaluated. The results indicated that the neutral and anionic clusters possess higher stability when n = 10 and 12. The vertical detachment energy (VDE) and adiabatic detachment energy (ADE) were also calculated for anionic cluster to investigate their stabilities. Among neutral clusters, VGe10 had both the highest vertical ionization potential (VIP) and chemical hardness. Keywords BP86/LANL2DZ, binding energy, VGen0/- clusters, structure of clusters References [1] Shunping Shi, Yiliang Liu, Chuanyu Zhang, Banglin Deng, Gang Jiang (2015). 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Today, Philippine society is confronted by different types of social problems that require solidarity with the poor, marginalized groups, and nature. In this regard, what can Filipino theologians do to address these challenges? Carlito “Karl” Gaspar, in thinking theologically, proposes to rediscover the precolonial Filipino spirituality to address the social issues. For Gaspar, precolonial Filipino spirituality is a transformative-oriented spirituality and inherently Maka-Diyos, Maka-Tao, Makakalikasan (For God, People, Nature). Gaspar argues that reclaiming the roots of our connection with precolonial spirituality could lead us towards developing solidarity with the poor, with marginalized groups, and with nature. Analyzing Gaspar’s The Masses Are Messiah: Contemplating the Filipino Soul (2010) as resource dissipation, this paper is an invitation to explore precolonial Filipino spirituality as a source to transform power structures. The paper is divided into five parts: First, the paper gives a brief introduction to the life and work of Karl Gaspar. Second, the paper offers an overview of Gaspar’s book, The Masses Are Messiah. Third, the paper discusses Gaspar’s transformative spirituality. Lastly, the paper advances the precolonial Filipino spirituality as a potential source for a holistic model of Filipino spirituality, especially for Filipino Pentecostal spirituality. Therefore, Filipino Pentecostal spirituality becomes meaningful, useful, and relevant in the Philippine context. References “Black Nazarene statue draws 800,000 Philippine Catholics to procession in Manila,” South China Morning Post, January 9, 2019. https://www.scmp.com/news/asia/southeast-asia/article/2181294/black-nazarene-statue-draws-800000-philippine-catholics. 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