Academic literature on the topic 'Science / Bacteriology'

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Journal articles on the topic "Science / Bacteriology"

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Rood, Sarah, and Katherine Sheedy. "Sydney Rubbo." Microbiology Australia 30, no. 3 (2009): 30. http://dx.doi.org/10.1071/ma09s30.

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Born in Sydney in 1911, Sydney Dattilo Rubbo was educated at Sydney Boys? High School and the University of Sydney (BSc, 1934) before travelling to London to further his studies. He obtained a diploma in bacteriology from the London School of Hygiene and Tropical Medicine (1935) and was awarded a scholarship for microbiological research at the University of London (PhD, 1937). Returning to Australia in 1937, Rubbo took up an appointment as a senior lecturer in the Department of Bacteriology at the University of Melbourne where he taught students of medicine, dentistry, science and agricultural science. A ?brilliant and provocative lecturer?, he inspired a generation of students. He also studied and completed a medical degree (MB, BS, 1943) and in 1945, at the age of 33, was appointed Professor of Bacteriology (Microbiology from 1964), a position he held until 1969.
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Wood, Brian J. B. "Methods in aquatic bacteriology." Endeavour 12, no. 4 (January 1988): 197. http://dx.doi.org/10.1016/0160-9327(88)90190-1.

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Vivarès, Christian P., and Jean-Luc Guesdon. "Nucleic acid probes in aquatic bacteriology." Aquaculture 107, no. 2-3 (October 1992): 147–54. http://dx.doi.org/10.1016/0044-8486(92)90060-x.

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Frampton, Sally. "Laboratory Disease: Robert Koch's Medical Bacteriology." Annals of Science 70, no. 1 (January 2013): 133–36. http://dx.doi.org/10.1080/00033790.2010.510934.

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Rowlands, A. "SOME RECENT RESEARCH IN DAIRY BACTERIOLOGY." International Journal of Dairy Technology 4, no. 4 (June 28, 2008): 240–42. http://dx.doi.org/10.1111/j.1471-0307.1951.tb02089.x.

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O'Brien, Mark, and Stephanie Beames. "Engaging students in clinical Bacteriology: a fresh look." Microbiology Australia 31, no. 1 (2010): 41. http://dx.doi.org/10.1071/ma10041.

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Frequently there is a disconnectedness, either perceived or actual, between theoretical principles and laboratory practice in science education and this holds true for clinical microbiology where traditionally knowledge is delivered in ?chunks? in a lecture format with the misguided belief that students have to know ?everything about everything?. This preoccupation with content delivery often leaves no time for active class discussion or reflection. Moreover, laboratory classes are treated as add-ons to the process, rather than an integrated part of the whole learning experience. In redesigning our units (subjects) we have bridged the gap between the theory and practice of clinical bacteriology. In doing so, we have seen a transformation in the learning experiences of our students and in the way we teach.
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Gradmann, Christoph. "Invisible Enemies: Bacteriology and the Language of Politics in Imperial Germany." Science in Context 13, no. 1 (2000): 9–30. http://dx.doi.org/10.1017/s0269889700003707.

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The ArgumentThe text analyzes the related semantics of bacteriology and politics in imperial Germany. The rapid success of bacteriology in the 1880s and 1890s was due not least to the fact that scientific concepts of bacteria as “the smallest but most dangerous enemies of mankind” (R. Koch) resonated with contemporary ideas about political enemies. Bacteriological hygiene was expected to provide answers to social and political problems. At the same time metaphors borrowed from bacteriological terminology were incorporated into the political language of the time. While the “high command of our doctors” (F. J. Cohn) fought diseases, some contemporaries were identified with members of the evil species of “bacillus communis odii.”Both imperialistic politics and bacteriological science relied on images of inferior and invisible but potent enemies. Both were able to increase their prestige via a mutual interchange of their vocabularies.
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Lamanna, Carl. "STUDIES OF ENDOGENOUS METABOLISM IN BACTERIOLOGY." Annals of the New York Academy of Sciences 102, no. 3 (December 15, 2006): 517–20. http://dx.doi.org/10.1111/j.1749-6632.1963.tb13657.x.

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Hagopian, Daniel S., and John G. Riley. "A closer look at the bacteriology of nitrification." Aquacultural Engineering 18, no. 4 (October 1998): 223–44. http://dx.doi.org/10.1016/s0144-8609(98)00032-6.

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Boot, R., and H. C. Walvoort. "Otitis media in guineapigs: pathology and bacteriology." Laboratory Animals 20, no. 3 (July 1, 1986): 242–48. http://dx.doi.org/10.1258/002367786780865601.

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In the course of post-mortem examination of conventional random-bred and inbred (immunosuppressed) strain 2/N guinea pigs kept in separate quarters, otitis media was diagnosed in 62 of 462 animals (13·4%) and 18 of 66 animals (27·3%) respectively. Clinical signs of otitis media were seen in only two randombred animals but in nearly 50% of affected inbred animals. In random-bred guineapigs, purulent, often bilateral, otitis media was associated mainly with the isolation of Streptococcus zooepidemicus, Bordetella bronchiseptica, Pasteurella and Actinobacillus spp. and micrococci. In strain 2/N guineapigs serous or purulent often bilateral otitis media was associated mainly with the isolation of B. bronchiseptica and Pseudomonas aeruginosa serotypes 10 and 11. The simultaneous occurrence of similar pathogenic bacteria in both ears of bilaterally affected animals and in pneumonic lung tissue (in random-bred animals) suggested ascending and descending infection originating from the upper respiratory tract. It is concluded that otitis media, associated with the isolation of a variety of respiratory bacterial species, must be considered a major disease problem in guineapigs.
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Dissertations / Theses on the topic "Science / Bacteriology"

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Kupferberg, Eric David. "The expertise of germs : practice, language and authority in American bacteriology, 1899-1924." Thesis, Massachusetts Institute of Technology, 2001. http://hdl.handle.net/1721.1/8669.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Program in Science, Technology and Society, 2001.
"February 2001."
Includes bibliographical references (v. 2, p. 631-784).
This thesis traces the development of American bacteriology during the first quarter of the twentieth century. While bacteriology experienced a period of rapid growth, an enduring disciplinary anxiety equally characterized the field. In particular, bacteriologists feared increasing specialization and conceptual fragmentation. Leading practitioners repeatedly worried that their science constituted a collection of unrelated techniques, carried out in the service to other practical endeavors without the benefit of an underlying theory or unifying language. I suggest that the sources of bacteriology's rapid professional growth equally accounted for this sense of conceptual impoverishment and disciplinary privation. Typically, bacteriologists focused on what bacteria did rather than what they were in any biological sense. The first three chapters provide a comprehensive survey of the institutional contexts bacteriology (e.g., medical schools, public health laboratories, water sanitation works, dairies, land-grant colleges, and agricultural experiment stations). For the most part, bacteriologists studied bacteria only so far as to isolate, identify and eliminate pathogens. Dairy and soil bacteriologists, however, sought to distinguish productive types of bacteria, and render those forms more active, a direction that led them to consider a range of phenomena and organisms normally occluded by the practices of medical, public health, and sanitary bacteriology.
(cont.) The final three chapters of the dissertation trace the attempts of American bacteriologists to render their science less fragmented and more biological, focusing in particular on the actions of the Society of American Bacteriologists (SAB). Established in 1899, the SAB endeavored to bridge the divergent interests and practices of American bacteriologists. Through its inclusive membership, ecumenical leadership, diverse meeting programs, and society journal, the SAB served as an organizational exploration of those shared aspects of the discipline. Furthermore, the SAB issued a comprehensive chart for the identification of unknown cultures. While never endorsed as its official methods, the chart soon formed the basis of undergraduate and graduate training, while it guided research programs and published papers. In addition, the serial revisions of the chart led bacteriologists to consider many fundamental aspects of bacteria. Lastly, the SAB struggled to reform bacterial systematics. At the time of the SAB's founding, bacteriology languished under a state of taxonomic chaos, with each specialty offering its own system of naming and grouping bacteria. Believing that this linguistic fragmentation precluded the emergence of a unified discipline, the SAB overhauled bacterial systematics, arranging bacteria according to their detailed morphology, physiology, and likely evolutionary histories.
(cont.) While the SAB's taxonomy did not find immediate adherents, it did become authoritative by way of the classroom and laboratory. The SAB issued a new comprehensive determinative guide, the Bergey's Manual of Determinative Bacteriology, which incorporated the SAB's scheme. As the Bergey's Manual became ubiquitous to laboratory practice and course instruction, American bacteriologists unwittingly adopted a broader range of considerations ...
by Eric D. Kupferberg.
Ph.D.
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Sangodeyi, Funke Iyabo. "The Making of the Microbial Body, 1900s-2012." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11692.

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This dissertation examines how the relationship between microbes and the human body has been reconfigured over the course of the twentieth century and into the first decades of the twenty-first century. It presents a counter-narrative to the ways in which we have tended to view microbe-human relations to make sense of the emergence of twenty-first century microbial selves by focusing on the normal microbiota.
History of Science
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Fuqua, Andrew. "Characterization of the Broad-spectrum Inhibitory Capability of Alcaligenes faecalis and A. viscolactis against Potential Pathogenic Microorganisms." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/honors/546.

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The recent rise of multidrug resistant microorganisms has grown from an isolated concern to a massive public health crisis. It has become imperative that scientists look for new ways to combat this issue. Due to the selective pressures of competition, bacteria and other microbes possess a host of defenses and weapons designed to exploit vulnerabilities in other microorganisms. Consequently, the study of these systems and microbial interactions has much to reveal in the search for novel antimicrobial treatments. Previous research from our laboratory has discovered that both Alcaligenes faecalis and Alcaligenes viscolactis, two rarely studied and generally non-virulent bacteria, exert a microbicidal effect on Candida albicans and Staphylococcus aureus, two pathogenic and frequently drug-resistant organisms. In this study, we confirmed that these effects are via a live-cell, contact-dependent mechanism and showed that both Alcaligenes species inhibit S. aureus at the attachment phase of biofilm growth. Additionally, we found that A. faecalis and A. viscolactis target Gram-positive bacteria outside the genus Staphylococcus and certain Gram-negative species as well as Candida glabrata. This study also provides novel evidence of a putative Type VI Secretion System in both Alcaligenes species, which may explain their antimicrobial phenotype. Despite efforts to identify the genetic elements involved via mutagenesis, the mechanism of these interactions remain elusive due to the difficulty of gene transfer in these organisms. We hope these results will increase current knowledge of Alcaligenes’ capabilities and genetic composition as well as establish the groundwork for future efforts to discover its inhibitory system and mechanisms.
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Liu, Yunhao. "Structural and biochemical analysis of HutD from Pseudomonas fluorescens SBW25 : a thesis submitted in fulfilment of the requirements for the degree of Master of Science in Molecular Biosciences at Massey University, Auckland, New Zealand." Massey University, 2009. http://hdl.handle.net/10179/1074.

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Pseudomonas fluorescens SBW25 is a gram-negative soil bacterium capable of growing on histidine as the sole source of carbon and nitrogen. Expression of histidine utilization (hut) genes is controlled by the HutC repressor with urocanate, the first intermediate of the histidine degradation pathway, as the direct inducer. Recent genome sequencing of P. fluorescens SBW25 revealed the presence of hutD in the hut locus, which encodes a highly conserved hypothetical protein. Previous genetic analysis showed that hutD is involved in hut regulation, in such a way that it prevents overproduction of the hut enzymes. Deletion of hutD resulted in a slow growth phenotype in minimal medium with histidine as the sole carbon and nitrogen source. While the genetic evidence supporting a role of hutD in hut regulation is strong, nothing is known of the mechanism of HutD action. Here I have cloned and expressed the P. fluorescens SBW25 hutD in E. coli. Purified HutD was subjected to chemical and structural analysis. Analytic size-exclusion chromatography indicated that HutD forms a dimer in the elution buffer. The crystal structure of HutD was solved at 1.80 Å (R = 19.3% and Rfree = 22.3%) by using molecular replacement based on HutD from P. aeruginosa PAO1. P. fluorescens SBW25 HutD has two molecules in an asymmetric unit and each monomer consists of one subdomain and two ß-barrel domains. Comparative structural analysis revealed a conserved binding pocket. The interaction of formate with a highly conserved residue Arg61 via salt-bridges in the pocket suggests HutD binds to small molecules with carboxylic group(s) such as histidine, urocanate or formyl-glutamate. The hypothesis that HutD functions via binding to urocanate, the hut inducer, was tested. Experiments using a thermal shift assay and isothermal titration calorimetry (ITC) analysis suggested that HutD binds to urocanate but not to histidine. However, the signal of HutD-urocanate binding was very weak and detected only at high urocanate concentration (53.23 mM), which is not physiologically relevant. The current data thus does not support the hypothesis of HutD-urocanate binding in vivo. Although the HutD-urocanate binding was not confirmed, this work has laid a solid foundation for further testing of the many alternative hypotheses regarding HutD function.
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Brunson, Debra Nickole. "Loss of outer membrane porins in clonally related clinical isolates of Klebsiella pneumoniae modifies the bacteria; resulting in altered resistance to phagocytosis by macrophages." UNF Digital Commons, 2017. http://digitalcommons.unf.edu/etd/724.

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Klebsiella pneumoniae is an opportunistic pathogen responsible for lobar pneumoniae, liver abscess, and septicemia. Clinical isolates are found to be extended spectrum beta lactamase positive with differential expression of the two classical porins, OmpK35 and OmpK36. Porin loss is associated with increased minimum inhibitory concentrations of beta lactam, cephalosporin, and carbapenem antibiotics that target the peptidoglycan. However, little is known about how porin loss affects other aspects of the cell envelope. The focus of this study was to characterize clinical isolates exhibiting differential porin expression and determine if the cumulative changes altered the resistance to phagocytosis by macrophages. The results support the hypothesis that porin loss significantly impacts the overall cell envelope composition, which in turn alters interactions with macrophages.
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Baxter, Brooke E. "Cloning and Expression of C-terminal Fragment of TonB from Rhizobium leguminosarum ATCC 14479." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/honors/410.

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The TonB-ExbB-ExbD complex is essential for the siderophore mediated acquisition of iron by Gram negative bacteria. The system provides energy from the proton motive force to the outer membrane in order for the iron siderophore complex to enter into the cell. The main protein involved in energy transduction, TonB, has been extensively studied in the species Escherichia Coli. It has been determined that the protein consists of 239 amino acids. In comparison, however, the TonB of Rhizobium leguminosarum consists of 457 amino acids with the same conserved regions. What is in question, therefore, is how the additional amino acids effect the structure of the C-terminal region of the protein and how such information can give insight into the way in which the proton motive force functions to provide energy to the outer membrane receptor. The protein regions of R. leguminosarum TonB chosen for study were 120 and 248 amino acids from the C-terminal end. Genomic DNA was isolated, primers were designed for each fragment, and polymerase chain reactions were performed. After appropriate restriction enzyme digestion, each DNA fragment was ligated into the plasmid pET-17b and then transformed into Escherichia Coli BL21 (DE3). Successful transformation of the 120 amino acid fragment was followed by expression via IPTG induction & extraction of protein. Afterwards, a T7-tag affinity column was attempted to collect the protein for analysis; however, a sufficient amount of protein was not eluted. The procedure will be repeated for obtaining sufficient protein for crystallization or NMR spectrometric analysis.
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Garcia-Moreno, Pamela K. "Mycobacterium tuberculosis inhibitors: action and resistance." FIU Digital Commons, 2018. https://digitalcommons.fiu.edu/etd/3893.

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Tuberculosis, an infectious disease caused by Mycobacterium tuberculosis, has been a global health problem for years. The emergence of drug resistance in this organism generates the necessity of exploring novel targets and developing new drugs. Topoisomerases are enzymes found in all kingdoms of life responsible for overcoming the topological barriers encountered during essential cellular processes. The genomes of mycobacteria encode only one type IA topoisomerase (MtopI), which has been validated as a novel TB drug target. The goal of this study is to obtain new information on the mechanism and resistance of endogenous and synthetic inhibitors of MtopI. Rv1495 is a M. tuberculosis toxin that belongs to the MazEF family (MazE is the antitoxin and MazF is the toxin), with endoribonuclease activity. Rv1495 (MazF homolog in M. tuberculosis) toxin has been shown to interact directly with the C-terminal domain of MtopI for mutual inhibition. In this study the interaction of Rv1495 with the positively charged C-terminal tail in Mtop I is reported. This new information is useful for rational design and discovery of antibiotics for mycobacteria. Ethacridine, an FDA approved drug has shown activity against MtopI. In this project we studied the mechanisms of resistance associated with this drug as well the use of Ethacridine in combination with Moxifloxacin, to potentiate the bactericidal effect of this current second line drug for TB treatment. Results from sequencing of the genomic DNA isolated from the resistant mutants suggested the involvement of the Holliday-junction Ruv resolvase. Further studies showed that co-treatment with Ethacridine can enhance the moxifloxacin-mediated killing of M. smegmatis. FP-11g, a novel fluoroquinophenoxazine inhibitor of bacterial topoisomerase I, has shown promising activity against M, tuberculosis. We explored the bactericidal activity and resistance mechanisms associated to FP-11g using M. smegmatis as model organism. Additionally, the inhibitory effect of FP-11g was also evaluated on M. abscessus. FP-11g at concentration 4X MIC showed complete bactericidal activity against M. smegmatis after 24 hours. Inhibitory activity against M. abscessus was also observed. Results from sequencing of the genomic DNA isolated from the M. smegmatis resistant mutants revealed mutations in genes associated with general drug resistance.
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Radomski, Nicolas. "Sources des mycobactéries non-tuberculeuses dans les bassins versants." Phd thesis, Université Paris-Est, 2011. http://pastel.archives-ouvertes.fr/pastel-00669399.

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L'eau et le sol sont considérés comme des sources potentielles de mycobactéries non-tuberculeuses (MNT). Parmi les infections humaines causées par les MNT d'origine environnementale, les infections pulmonaires et cutanées sont souvent décrites. Le manque de connaissances sur leur cycle de vie dans l'environnement requiert des outils analytiques, qui ne sont actuellement pas adaptés à ce type d'échantillons. Cette thèse vise donc premièrement à proposer des méthodes de quantification en bactériologie et en biologie moléculaire dans le but de déterminer les sources des MNT dans les bassins versants. Ainsi, la comparaison des méthodes d'isolement de MNT a montré que le traitement au chlorure de cetylpyridininium de l'eau suivi d'une culture en milieu riche supplémenté par un mélange d'antibiotiques (polymyxine B, amphotéricine, acide nalidixique, triméthoprime, carboxy-pénicilline) limitait la croissance des microorganismes interférents et éliminait moins de MNT que les autres méthodes comparées (Radomski et al. 2010, doi: 10.1128/AEM.00942-10). Bien que des espèces de MNT potentiellement pathogènes aient été isolées de l'eau de surface de la Seine en utilisant ces outils bactériologiques, la quantification des MNT ne s'est pas avérée reproductible. En conséquence, une méthode de quantification par polymérisation en chaîne en temps réel (qPCR) a été développée pour énumérer le genre Mycobacterium dans l'eau (Radomski et al. 2010, doi: 10.1128/AEM.02659-09). La nouvelle méthode développée, ciblant l'ARNr 16S, était plus spécifique que les autres méthodes qPCR publiées, ciblant un autre locus de l'ARNr 16S et le gène hsp65 (respectivement 100 % versus 44 % et 91 %). La comparaison des méthodes d'extraction d'ADN mycobactérien a montré que la lyse enzymatique combinée au bromure d'hexadécyltriméthylammonium était la procédure la plus efficace pour énumérer par qPCR les MNT dans des échantillons environnementaux. Ainsi, ces méthodes d'extraction d'ADN et de qPCR ont été utilisées pour étudier des sources de MNT dans des bassins versants. Dans un second temps, nous avons étudié trois sources potentielles de MNT : une ponctuelle et deux diffuses. Plus précisément, une station d'épuration (STEP) a été choisie comme source ponctuelle de MNT et a été étudiée en temps sec en fonction d'indicateurs de contamination fécale et des paramètres globaux habituellement contrôlés. Les MNT ont atteint 5,52×105±3,97×105 copies/L dans l'eau en entrée de STEP (84 % d'échantillons positifs), n'ont pas été détectées dans l'eau en sortie de STEP après décantation physico-chimique et biofiltration et ont été estimées à 1,04×106 ±1,75×106 copies/g dans les boues de STEP (50 % d'échantillons positifs). La plupart des MNT (98±2 %, correspondant à 2,45±0,78 log10) ont été éliminées par décantation physico-chimique et les MNT restantes (0,74×104 ±1,40×104 copies/L) ont été éliminées par biofiltration (53 % d'échantillons positifs). Ces résultats ont montré également que Mycobacterium, Escherichia coli et les entérocoques intestinaux possèdent des comportements significativement différents conduisant respectivement à trois modèles : hydrophobe, hydrophile et intermédiaire. Concernant les sources diffuses, la densité de MNT a été mesurée dans divers sols ruraux et urbains qui ont été caractérisés par différents paramètres physico-chimiques. Les densités de MNT les plus importantes ont été mesurées dans des sols de forêts tourbeuses (9,27×104±5,00×104 copies/g sec) et dans des sols faiblement urbanisés proches de marécages côtiers (1,71×106±2,85×106 copies/g sec) alors qu'aucune MNT n'a été détectée dans les autres types de sols étudiés. De plus, la densité de MNT a été significativement associée à des sols proches de zones acides et des teneurs fortes des sols en eau, matière organique et fer. Ces résultats suggéreraient que les MNT sont dépendantes de leur production intra et extracellulaire de chélateurs de fer et indiqueraient que les zones faiblement urbanisées pourraient être impactées par la proximité de marais acides. Afin d'étudier une autre source diffuse, les MNT et d'autres paramètres ont été mesurés lors d'événements pluvieux dans l'eau de surface de la Marne et de ses principaux affluents. Les densités de MNT ont été estimées à 2,16×105±2,36×105 copies/L dans environ 20 % des échantillons d'eau collectés, et elles ne différaient pas entre les zones péri-urbaines et rurales échantillonnées. Nos résultats ont montré que la pluviométrie et la durée de l'évènement expliquaient la diminution du nombre de MNT détectées dans l'eau de surface au cours de l'événement pluvieux de faible intensité (6,6 mm/h de pluviométrie cumulées en 5,5 h). Ces résultats ont souligné que certains affluents de la Marne pouvaient apporter des MNT en temps sec, mais qu'au cours de l'évènement pluvieux suivi les densités de MNT diminuaient.En guise d'amélioration à ces études appliquées, des réflexions sur les défis relatifs à la surveillance des microorganismes pathogènes dans l'environnement ont été explorées. En nous focalisant sur la MNT la plus pathogène, M. avium, nous avons discuté des défis de la détection et de l'énumération et proposé un guide d'adaptation des méthodes médicales aux échantillons environnementaux (Radomski et al. 2011, ed. A. Méndez-Vilas, Vol. 2). Ce guide se présente sous la forme d'un arbre de décision permettant de choisir les outils analytiques les plus appropriés pour surveiller les microorganismes pathogènes dans l'environnement. De plus, une stratégie in silico de comparaison de génomes bactériens totalement séquencés a été développée dans le but de décrire des nouvelles cibles de détection. L'analyse in silico des génomes totalement séquencés a permis de détecter 11 protéines présentant entre 80 % et 100 % de similarité dans les génomes mycobactériens et moins de 50 % de similarité dans les génomes non-mycobactériens des genres Corynebacterium, Nocardia et Rhodococcus. Sur la base d'alignements des séquences d'ADN de ces cibles potentielles, il a été possible de dessiner des amorces PCR et une sonde pour détecter le gène codant la sous-unité C de la synthase de l'adénosine triphosphate qui semble exclusivement conservée dans le génome mycobactérien. Le développement d'outils analytiques, en particulier la qPCR, a permis de montrer qu'une STEP éliminait efficacement les MNT et que le traitement des eaux usées est nécessaire pour préserver l'eau de surface de cette source ponctuelle de MNT. Il a été mis en évidence que les événements pluvieux diminuent la densité de MNT dans l'eau de surface et que les sols acides sont des sources naturelles majeures de MNT qui pourraient impacter des zones faiblement urbanisées en temps de pluie via le ruissellement. Concernant les réflexions sur la surveillance des microorganismes pathogènes dans l'environnement, l'arbre de décision des outils analytiques appropriés et la nouvelle stratégie in silico de détection de cibles moléculaires pourraient être appliqués pour l'étude d'autres microorganismes de l'environnement
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Pullen, Sheryl L. "In vitro activity of four fluoroquinolones on selected bacteria." Scholarly Commons, 1995. https://scholarlycommons.pacific.edu/uop_etds/2285.

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In 1990-1991, in a national surveillance study, and in 1991-1992, in a followup study, both by Thornsberry et al. (1993), ciprofloxacin data from various geographical and demographical institutions were collected. Several species of bacteria have shown resistance to ciprofloxacin and norfloxacin, but the degree of resistance to these drugs has not been reported for the Stockton area. To determine the extent of this resistance, Dameron Hospital antibiograms generated from 1990 to 1994 were reviewed and compared. Results of the comparison show that susceptibility among the Gram-negative isolates, with the exception of Providencia stuartii, Acinetobacter lwoffi, and to a lesser extent Aeromonas hydrophila, has changed very little. Consistent with the national surveys, resistance of Pseudomonas aemginosa has not changed appreciably during the five-year period. Among the Gram-positive isolates that were tested against both ciprofloxacin for a five-year period (1990-1994) and norfloxacin for a three-year period (1992"' 1994), increased resistance was seen among strains of Staphylococcus aureus, S. epidermidis, S. haemolyticus, and Enterococcus jaecalis, but not among strains of Staphylococcus saprophyticus, Streptococcus pyogenes, and S. agalactiae. To determine whether resistance to one fluoroquinolone occurs also to other fluoroquinolones, several isolates of Gram-positive cocci and P. aeruginosa from the Gram-negative bacilli that showed resistance to either ciprofloxacin, norfloxacin, or both were selected from Dameron Hospital isolates and tested by the disk diffusion technique against ciprofloxacin, norfloxacin, ofloxacin, and lomefloxacin. The results indicate that differences do exist among these selected strains. Comparison of the invitro effectiveness of the various quinolones confirms that methicillin-resistant staphylococci (S. aureus, S. epidermidis, and S. haemolyticus) exhibit a higher degree of resistance to the four fluoroquinolones compared with the methicillin-susceptible strains of the same species. Resistance of the enterococci (Enterococcus jaecalis and E. jaecium) is also high. Generally, when the four fluoroquinolones were compared with each other, ofloxacin seemed to have better in vitro activity. Resistance to the quinolones consists of two proposed mechanisms: ( 1) mutation of one or both of the structural genes of the A and B subunits of DNA gyrase and (2) decreased drug accumulation due either to lower uptake by the cell or enhanced effiux out of the cell. These mechanisms of resistance are reviewed.
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Presswood, Rachel Elizabeth. "Isolation of a Siderophore Produced by Methicillin-Resistant Staphylococcus aureus Strain H372." Digital Commons @ East Tennessee State University, 2010. https://dc.etsu.edu/etd/1728.

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Iron is necessary for many cellular processes such as the electron transport chain and gene regulation. However, most iron on earth is found in insoluble iron-hydroxide complexes. In addition, iron is tightly sequestered in the human body by proteins such as transferrin, making it unavailable for pathogens. In order to overcome these limitations bacteria have evolved siderophores. Siderophores are low molecular weight compounds that bind ferric iron with a high affinity. Staphylococcus aureus is an important human pathogen that is known to produce at least four siderophores, and these siderophores contribute to its virulence. S. aureus strain H372 was found to produce a siderophore that was a carboxylate type, hydrophilic, and contained ornithine. These properties were similar to the known siderophore staphyloferrin A. However, the probable molecular weight was 658, which is different from known staphylococcal siderophores.
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Books on the topic "Science / Bacteriology"

1

Koninkx, Jos F. J. G. (Joseph Frans Jan Gerard), 1944-, Marinšek-Logar Romana 1960-, and SpringerLink (Online service), eds. Probiotic Bacteria and Enteric Infections: Cytoprotection by Probiotic Bacteria. Dordrecht: Springer Science+Business Media B.V., 2011.

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European Workshop on Bacterial Protein Toxins (6th 1993 Stirling, Scotland). Bacterial protein toxins: Sixth European Workshop, Stirling, June 27-July 2, 1993. Edited by Freer J. H and Federation of European Microbiological Societies. Stuttgart: G. Fischer, 1994.

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1932-, Mathieu Léo G., ed. Prokaryotology: A coherent point of view. Montréal: Presses de l'Université de Montréal, 2000.

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Cadeddu, Antonio. Les vérités de la science: Pratique, récit, histoire : le cas Pasteur. Firenze: L. S. Olschki, 2005.

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Charalampopoulos, Dimitris. Prebiotics and Probiotics Science and Technology. New York, NY: Springer New York, 2009.

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J, VanDemark Paul, and Lee John J. 1933-, eds. Selected exercises from Microbes in action: A laboratorymanual of microbiology. 4th ed. Oxford: W.H. Freeman, 1991.

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Brian, Spooner, Læss[%]e Thomas, and Royal Botanic Gardens Kew, eds. British puffballs, earthstars and stinkhorns: An account of the British gasteroid fungi. [London]: Royal Botanic Gardens, Kew, 1995.

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Varnam, A. H. Foodborne pathogens: An illustrated text. Aylesbury, Eng: Wolfe Pub., 1991.

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International, Symposium on Fungal Antigens (1st 1986 Paris France). Fungal antigens: Isolation, purification, and detection. New York: Plenum Press, 1988.

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S, Rosen Fred, ed. Case studies in immunology: A clinical companion. 5th ed. New York, NY: Garland Science, Taylor and Francis Group, 2007.

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Book chapters on the topic "Science / Bacteriology"

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Fox, Patrick F., Timothy P. Guinee, Timothy M. Cogan, and Paul L. H. McSweeney. "Bacteriology of Cheese Milk." In Fundamentals of Cheese Science, 105–20. Boston, MA: Springer US, 2016. http://dx.doi.org/10.1007/978-1-4899-7681-9_5.

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Finlay, Mark R. "Science, Promotion, and Scandal: Soil Bacteriology, Legume Inoculation, and the American Campaign for Soil Improvement in the Progressive Era." In Archimedes, 205–29. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-12185-7_11.

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Holzapfel, W. H., S. D. Todorov, and T. M. Cogan. "History of Dairy Bacteriology." In Reference Module in Food Science. Elsevier, 2020. http://dx.doi.org/10.1016/b978-0-08-100596-5.23031-x.

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Sonea, Sorin, and Léo G. Mathieu. "Chapter I. Uneven development of the science of bacteriology." In Prokaryotology, 13–28. Presses de l’Université de Montréal, 2000. http://dx.doi.org/10.4000/books.pum.14301.

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Weindling, Paul. "A virulent strain German bacteriology as scientific racism, 1890–1920." In Race, Science and Medicine, 1700–1960, 218–34. Routledge, 2002. http://dx.doi.org/10.4324/9780203025420-10.

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"Bacteriology and antibiotics." In Biotechnology in Medical Sciences, 59–82. CRC Press, 2014. http://dx.doi.org/10.1201/b16905-4.

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"Bacteriology and antibiotics." In Biotechnology in Medical Sciences, 86–109. CRC Press, 2014. http://dx.doi.org/10.1201/b16905-7.

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Cogan, T. M. "Introduction | History of Dairy Bacteriology." In Encyclopedia of Dairy Sciences, 26–33. Elsevier, 2011. http://dx.doi.org/10.1016/b978-0-12-374407-4.00543-4.

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Rothstein, William G. "Medical Education, 1900–1950: Clinical Teaching." In American Medical Schools and the Practice of Medicine. Oxford University Press, 1987. http://dx.doi.org/10.1093/oso/9780195041866.003.0017.

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The professionalization of academic medicine occurred in the clinical as well as the basic science curriculum. Full-time clinical faculty members replaced part-time faculty members in the wealthier schools. Medical specialties, many of which were rare outside the medical school, dominated the clinical courses. Clinical teaching, which was improved by more student contact with patients, occurred primarily in hospitals, whose patients were atypical of those seen in community practice. The growing importance of hospitals in medical education led to the construction of university hospitals. Early in the century, some leading basic medical scientists called for full-time faculty members in the clinical fields. They noted that full-time faculty members in the basic sciences had produced great scientific discoveries in Europe and had improved American basic science departments. In 1907, William Welch proposed that “the heads of the principal clinical departments, particularly the medical and the surgical, should devote their main energies and time to their hospital work and to teaching and investigating without the necessity of seeking their livelihood in a busy outside practice” Few clinicians endorsed this proposal. They found the costs prohibitive and disliked the German system of medical research and education on which it was based. Medical research in Germany was carried on, not in medical schools, but in government research institutes headed by medical school professors and staffed by researchers without faculty appointments. All of the researchers were basic medical scientists who were interested in basic research, not practical problems like bacteriology. Although the institutes monopolized the available laboratory and hospital facilities, they were not affiliated with medical schools, had no educational programs, and did not formally train students, although much informal training occurred. For these reasons, their research findings were seldom integrated into the medical school curriculum, and German medical students were not trained to do research. German medical schools had three faculty ranks. Each discipline was headed by one professor, who was a salaried employee of the state and also earned substantial amounts from student fees. Most professors had no institute appointments and did little or no research.
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Brazelton, Mary Augusta. "Journey to the Southwest." In Mass Vaccination, 15–32. Cornell University Press, 2019. http://dx.doi.org/10.7591/cornell/9781501739989.003.0001.

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This chapter discusses microbiology in China's early twentieth century. In contrast to other narratives, the emergence of microbiology as a discipline in China during the early twentieth century did not rely on any single organization, charismatic leader, or colonial influence. Instead, multiple institutes and universities in Beijing, Nanjing, Shanghai, and other cities emerged as centers for research, and a small group of highly educated physicians and scientists participated in global research networks, even as they trained Chinese students and advised local health administrations. In the 1920s and 1930s, emerging fields such as immunology, virology, and bacteriology were identified with broader categories of inquiry, such as the medical sciences or microbiology. In addition to laboratory research, Chinese researchers translated new terms into Chinese and established professional organizations. Although research programs in microbiology were productive, their applications to public health were limited to specific projects in major cities. One important urban institution was the National Epidemic Prevention Bureau. After its 1919 establishment in Beijing, the bureau became a center for vaccine production and sponsored limited urban immunization campaigns. The outbreak of formal war with Japan in 1937 and the subsequent move of many researchers to the southwest disrupted the development of microbiology in China. Yet it also created opportunities for new cooperative relationships to form in the field of public health.
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Conference papers on the topic "Science / Bacteriology"

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Yolanda, Siska, Meiskha Bahar, and Cut Fauziah. "The Analysis of Bacteriology And Antibiotic Resistance to Salmonella Isolated in Fried Rolled Eggs at The Elementary School in Jatinegara District November-December 2017." In Proceedings of the 5th International Conference on Health Sciences (ICHS 2018). Paris, France: Atlantis Press, 2019. http://dx.doi.org/10.2991/ichs-18.2019.34.

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