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Journal articles on the topic 'Scopolamine and antioxidant'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Neeraj, Kumar* Chetna Dhiman Preeti Kothiyal. "EVALUATION OF ANETHUM GRAVEOLENS EXTRACT ON MEMORY IMPAIRED MICE." Indo American Journal of Pharmaceutical Sciences 04, no. 07 (2017): 1965–75. https://doi.org/10.5281/zenodo.833451.

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Objective:The objective of this study was to evaluate the effect of Anethum graveolens (Dill) extract on scopolamine induced learning and memory impairment in mice. The antioxidant property of Anethum graveolens was evaluated. Material and methods: A total of 36 mice (25-30 g) were randomized into 6 equal groups. Memory enhancing activity of Anethum graveolens in amnesic mice was investigated by using Elevated plus maze and Morris water maze. AchE activity, SOD and lipid peroxidation of brain homogenate were performed in control/ scopolamine/ standard / Anethum graveolens leaves extract treate

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Balakrishnan, Rengasamy, Ju-Young Park, Duk-Yeon Cho та ін. "AD−1 Small Molecule Improves Learning and Memory Function in Scopolamine-Induced Amnesic Mice Model through Regulation of CREB/BDNF and NF-κB/MAPK Signaling Pathway". Antioxidants 12, № 3 (2023): 648. http://dx.doi.org/10.3390/antiox12030648.

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Cognitive decline and memory impairment induced by oxidative brain damage are the critical pathological hallmarks of Alzheimer’s disease (AD). Based on the potential neuroprotective effects of AD−1 small molecule, we here explored the possible underlying mechanisms of the protective effect of AD-1 small molecule against scopolamine-induced oxidative stress, neuroinflammation, and neuronal apoptosis. According to our findings, scopolamine administration resulted in increased AChE activity, MDA levels, and decreased antioxidant enzymes, as well as the downregulation of the antioxidant response p

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Ankita, Bhardwaj*and Suruti Rawat. "INVESTIGATION OF GLIMEPIRIDE IN STREPTOZOTOCIN AND SCOPOLAMINE INDUCED LEARNING AND MEMORY IMPAIRMENT IN RATS." Indo American Journal of Pharmaceutical Sciences 04, no. 08 (2017): 2564–73. https://doi.org/10.5281/zenodo.852485.

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The present study was designed to evaluate the therapeutic potential of Glimepiride in Streptozotocin and Scopolamine induced Learning and Memory Impairment in Rats. Memory enhancing activity of glimepiride in STZ and scopolamine induced learning and memory impairment in rats was investigated by using Morris water maze. SOD, lipid peroxidation, glutathione level of brain homogenate was performed.Rats were randomly assigned to 9 groups (n = 6 each group): (1-5 Groups): control, STZ (60 mg/kg i.p.), insulin (0.5 Units insulin per 100gm body weight), Glimepiride (5 and 10 mg/kg, p.o.) for 28 days

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Ishola, Ismail O., Taiwo G. Olubodun-Obadun, Mariam A. Ojulari, and Olufunmilayo O. Adeyemi. "Rutin ameliorates scopolamine-induced learning and memory impairments through enhancement of antioxidant defense system and cholinergic signaling." Drug Metabolism and Drug Interactions 36, no. 1 (2020): 53–61. http://dx.doi.org/10.1515/dmpt-2020-0118.

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Abstract Objectives The brain’s cholinergic system occupies a central role in normal cognition and age-related cognitive decline, including Alzheimer’s disease (AD). This study sought to investigate the role of antioxidant defense and cholinergic systems on rutin-induced antiamnesia in mice. Methods Rutin (1, 5, or 50 mg/kg, p.o.) or vehicle (10 ml/kg, p.o.) was administered for three consecutive days. One hour post-treatment on day 3, scopolamine (3 mg/kg, i.p) was given, 5 min post-scopolamine injection, open field, Y-maze, or Morris water maze (MWM) (five days consecutive training sessions)

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Todirascu-Ciornea, Elena, Heba A. S. El-Nashar, Nada M. Mostafa, et al. "Schinus terebinthifolius Essential Oil Attenuates Scopolamine-Induced Memory Deficits via Cholinergic Modulation and Antioxidant Properties in a Zebrafish Model." Evidence-Based Complementary and Alternative Medicine 2019 (December 2, 2019): 1–11. http://dx.doi.org/10.1155/2019/5256781.

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Schinus terebinthifolius is a plant well recognized for its therapeutic profile such as anti-inflammatory and antitumor activities, promoting antibacterial activity and antioxidant and antidiabetic properties. This study aimed at examining whether Schinus terebinthifolius memory-enhancing activities are mediated by cholinergic and brain antioxidant systems in a scopolamine zebrafish model. Schinus terebinthifolius essential oil (10, 25, and 50 μL/L) was delivered to zebrafish by immersion in water for 8 days. Memory deficits were induced by scopolamine (100 μM) administration. Zebrafish were d

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Biradar, SM, H. Joshi, and TK Chheda. "Biochanin-A ameliorates behavioural and neurochemical derangements in cognitive-deficit mice for the betterment of Alzheimer’s disease." Human & Experimental Toxicology 33, no. 4 (2013): 369–82. http://dx.doi.org/10.1177/0960327113497772.

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Biochanin-A (BCA), a potent phytoconstituent, has been previously used as an antitumour, a dopaminergic neuron protective agent, an antioxidant, an anticholinergic and on other pharmacological activities including neuroprotection. The present study was aimed to evaluate the behavioural and neurochemical evidence of BCA in cognitive-deficit mice in scopolamine challenged and natural aged-induced amnesia models in young and aged mice, respectively. BCA has exhibited decrease in the transfer latency and increase in step through latency significantly ( p < 0.001) in scopolamine-treated and natu

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Thangnipon, Wipawan, Sukonthar Ngampramuan, Nopparat Suthprasertporn, Chanati Jantrachotechatchawan, Patoomratana Tuchinda, and Saksit Nobsathian. "Protective Roles of N-trans-feruloyltyramine Against Scopolamine-Induced Cholinergic Dysfunction on Cortex and Hippocampus of Rat Brains." Siriraj Medical Journal 73, no. 6 (2021): 413–22. http://dx.doi.org/10.33192/smj.2021.55.

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Objective: To study the protective effects of N-trans-feruloyltyramine (NTF) on scopolamine-induced cholinergic dysfunction, apoptosis, and inflammation in rat brains. Materials and Methods: Treatments were administered intraperitoneally (i.p.). Wistar rats (8-week-old) were allocated into 4 groups (n = 3) as follows: scopolamine-only, NTF-only, NTF + scopolamine and control. Spatial cognition was evaluated by Morris water maze. ROS assay and Western blot analyses were conducted in 3 brain regions: the frontal cortex, hippocampus, and temporal cortex. Results: NTF treatment inhibited scopolami

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Ashiekaa, Moses Ternenge, Innocent Abi, Aver Maria Yongu, Sunday Adakole Ogli, and Olasupo Stephen Adeniyi. "Scopolamine-induced brain injury and lipid peroxidation in Wistar rats ameliorated by garlic oil supplementation." Journal of African Association of Physiological Sciences 12, no. 1 (2024): 10–18. http://dx.doi.org/10.4314/jaaps.v12i1.2.

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Background: Scopolamine induced toxicity has been linked to impaired learning and memory, lipid peroxidation, oxidative stress and impairment of cholinergic transmission resulting in brain injury; which are synonymous with features of neurodegenerative diseases such as Alzheimer’s disease. Garlic oil has been found to be a possible therapeutic intervention. Its antioxidant and anticholinesterase activity were evaluated in scopolamine-induced brain toxicity in Wistar rats.Methods: The animals were grouped into seven groups (n=5). Group I (Normal Control) was given 1mL/kg distilled water for 14d

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Capatina, Luminita, Razvan Stefan Boiangiu, Gabriela Dumitru, et al. "Rosmarinus officinalis Essential Oil Improves Scopolamine-Induced Neurobehavioral Changes via Restoration of Cholinergic Function and Brain Antioxidant Status in Zebrafish (Danio rerio)." Antioxidants 9, no. 1 (2020): 62. http://dx.doi.org/10.3390/antiox9010062.

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Rosmarinus officinalis L. is a traditional herb with various therapeutic applications such as antibacterial, antioxidant, anti-inflammatory, antidepressant, and anticholinesterase activities, and can be used for the prevention or treatment of dementia. In the present study, we tested whether Rosmarinus officinalis L. could counteract scopolamine-induced anxiety, dementia, and brain oxidative stress in the zebrafish model and tried to find the underlying mechanism. Rosmarinus officinalis L. essential oil (REO: 25, 150, and 300 µL/L) was administered by immersion to zebrafish (Danio rerio) once

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Razuvaeva, Yanina G., Kristina V. Markova, Anyuta A. Toropova, Nina I. Kashchenko, and Daniil N. Olennikov. "Chemical Constituents, Neuroprotective and Antioxidant Potential of Klasea centauroides Leaves." Applied Sciences 13, no. 2 (2023): 860. http://dx.doi.org/10.3390/app13020860.

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Owing to progressive aging in the population, there is an increase in patients with cognitive impairment. For the prevention of dementia, the use of plant remedies is relevant. Of particular interest is Klasea centauroides (L.) Cass. (Serratula centauroides L., Asteraceae), which has significant natural reserves, contains a wide range of biologically active substances, and is used in folk medicine to treat nervous system diseases. This study aimed to estimate the neuroprotective, energy-protective, and antioxidant effects of K. centauroides extract in cholinergic deficiency caused by long-term

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Ababei, Daniela-Carmen, Ioana-Miruna Balmus, Walther Bild, et al. "The Impact of Some Modulators of the Renin–Angiotensin System on the Scopolamine-Induced Memory Loss Mice Model." Brain Sciences 13, no. 8 (2023): 1211. http://dx.doi.org/10.3390/brainsci13081211.

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As some of the renin–angiotensin–aldosterone system (RAAS)-dependent mechanisms underlying the cognitive performance modulation could include oxidative balance alterations, in this study we aimed to describe some of the potential interactions between RAAS modulators (Losartan and Ramipril) and oxidative stress in a typical model of memory impairment. In this study, 48 white male Swiss mice were divided into six groups and received RAAS modulators (oral administration Ramipril 4 mg/kg, Losartan 20 mg/kg) and a muscarinic receptors inhibitor (intraperitoneal injection scopolamine, 0.5 mg/kg) for

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Kim, Kwan Joong, Eun-Sang Hwang, Min-Jeong Kim, et al. "Effects of Phenolic-Rich Pinus densiflora Extract on Learning, Memory, and Hippocampal Long-Term Potentiation in Scopolamine-Induced Amnesic Rats." Antioxidants 11, no. 12 (2022): 2497. http://dx.doi.org/10.3390/antiox11122497.

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Alzheimer’s disease is the most common type of dementia with cognitive impairment. Various plant-derived phenolics are known to alleviate cognitive impairment in Alzheimer’s disease by radical scavenging and strengthening synaptic plasticity activities. Here, we examined the cognition-improving effect of Pinus densiflora Sieb. et Zucc. bark extract (PBE). We identified and quantified phenolics in the PBE using a UHPLC-Orbitrap mass spectrometer. To evaluate the cognition-enhancing effects of PBE, scopolamine-induced amnesic Sprague-Dawley (SD) rats (5 weeks old) and ion channel antagonist-indu

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Petkova-Kirova, Polina, Neda Anastassova, Borislav Minchev, et al. "Behavioral and Biochemical Effects of an Arylhydrazone Derivative of 5-Methoxyindole-2-Carboxylic Acid in a Scopolamine-Induced Model of Alzheimer’s Type Dementia in Rats." Molecules 29, no. 23 (2024): 5711. https://doi.org/10.3390/molecules29235711.

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Alzheimer’s disease (AD) has long proven to be a complex neurodegenerative disorder, with cholinergic dysfunction, oxidative stress, and neuroinflammation being just a few of its pathological features. The complexity of the disease requires a multitargeted treatment covering its many aspects. In the present investigation, an arylhydrazone derivative of 5-methoxyindole-2-carboxylic acid (5MeO), with in vitro strong antioxidant, neuroprotective and monoamine oxidase B-inhibiting effects, was studied in a scopolamine-induced Alzheimer-type dementia in rats. Using behavioral and biochemical method

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Okeniran, Olutayo, Ifeanyi Aja, Babatunde Ade, Samuel Ajayi, Adeshina Ajibade, and Adejoke Onaolapo. "Ethanol extract of Thaumatococcus Danielli leaves mitigates Scopolamine-induced Behavioural and morphological changes in the Prefrontal cortex of Wistar rats." Acta Bioscientia: Journal of Biomedical and Biological Science Research 1, no. 3 (2025): 161–68. https://doi.org/10.71181/actabioscientia12310.

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The antioxidant potential of ethanol extract of Thaumatococcus danielli (T. danielli) leaves has been reported severally, however, there is a dearth of scientific information on its effect on scopolamine-induced changes in the rat prefrontal cortex. This study assessed the neuroprotective potential of ethanolic extract of Thaumatococcus danielli leaves on scopolamine induced neurotoxicity in rats. Eighty (80) adult Wistar rats weighing 180-200g were randomly divided into eight groups of 10 rats each. Group A was administered distilled water orally (10 ml/kg) and intraperitoneally (2ml /kg), gr

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Ban, Ju Yeon, Hyun Kyung Park, and Su Kang Kim. "Effect of Glycyrrhizic Acid on Scopolamine-Induced Cognitive Impairment in Mice." International Neurourology Journal 24, Suppl 1 (2020): S48–55. http://dx.doi.org/10.5213/inj.2040154.077.

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Purpose: Cognitive impairment is one of the main symptoms of Alzheimer disease and other dementias. Glycyrrhiza uralensis is a natural product that has a protective effect against cognitive impairment. In this study, we investigated whether glycyrrhizic acid, among the main bioactive components of <i>Glycyrrhiza uralensis</i>, has a neuroprotective effect on scopolamine-induced cognitive impairment.Methods: Twenty-week-old male Institute of Cancer Research mice were used in this study. The scopolamine-induced cognitive impairment mice model was used. Glycyrrhizic acid was orally ad

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Kim, Yoonsu, Minjung Cho, Jeong Soon Lee, Jisun Oh, and Jinkyu Lim. "Protocatechuic Acid from Euonymus alatus Mitigates Scopolamine-Induced Memory Impairment in Mice." Foods 13, no. 17 (2024): 2664. http://dx.doi.org/10.3390/foods13172664.

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The increasing prevalence of age-related neurodegenerative disorders owing to the aging population worldwide poses substantial challenges. This study investigated the neuroprotective effects of protocatechuic acid (PCA), a compound found in various fruits, vegetables, and grains, using a scopolamine-induced hypomnesia mouse model. Six-week-old male C57BL/6J mice were orally administered PCA at doses of 10 and 100 mg/kg body weight per day for two weeks, along with intraperitoneal injections of scopolamine. Learning and memory abilities were assessed using the passive avoidance, Morris water ma

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Ishola, Ismail O., Taiwo Grace Olubodun-Obadun, Abisola Sekinat Akinwande, and Olufunmilayo Olaide Adeyemi. "Cajanus cajan (L) Millsp. seed extract ameliorates scopolamine-induced amnesia through increase in antioxidant defense mechanisms and cholinergic neurotransmission." Nigerian Journal of Physiological Sciences 38, no. 1 (2023): 91–99. http://dx.doi.org/10.54548/njps.v38i1.13.

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Decline in cholinergic function and oxidative/nitrosative stress play a central role in Alzheimer’s disease (AD). Previous quantitative HPLC profiling analysis has revealed the presence of Pinostrobin, formononetin, vitexin and other neuroprotective flavonoids in Cajanus cajan seed extract. This study was designed to investigate the protective action of Cajanus cajan ethanol seed extract (CC) on learning and memory functions using scopolamine mouse model of amnesia. Materials and methods: Adult mice were pretreated with CC (50, 100, or 200mg/kg, p.o) or vehicle (10ml/kg, p.o) for 16 days conse

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Valu, Mihai-Vlad, Catalin Ducu, Sorin Moga, et al. "Effects of the Hydroethanolic Extract of Lycopodium selago L. on Scopolamine-Induced Memory Deficits in Zebrafish." Pharmaceuticals 14, no. 6 (2021): 568. http://dx.doi.org/10.3390/ph14060568.

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This scientific research focused on the production of hydroethanolic extract of the plant species Lycopodium selago L. (L. selago) by the ultrasound-assisted extraction (USAE) and the identification of biocompounds with high antioxidant activity is of interest for possible phytotherapeutic treatment against Alzheimer’s disease (AD). The extract was phytochemically analyzed to investigate polyphenols, flavonoids, and identify the sesquiterpenoid alkaloid huperzine A (HupA), which is known in the literature for its great relevance in AD. Evaluation and comparison of the antioxidant activity of t

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Mostafa, Nada M., Ahmed M. Mostafa, Mohamed L. Ashour, and Sameh S. Elhady. "Neuroprotective Effects of Black Pepper Cold-Pressed Oil on Scopolamine-Induced Oxidative Stress and Memory Impairment in Rats." Antioxidants 10, no. 12 (2021): 1993. http://dx.doi.org/10.3390/antiox10121993.

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Oxidative stress is usually associated with many neurodegenerative diseases. In this study, the gas chromatography–mass spectrometry (GC–MS) analysis of cold-pressed oil (CPO) from black pepper (Piper nigrum) fruits was performed and its neuroprotective effects were evaluated for the first time. The analysis of CPO revealed the presence of the lignan sesamin (39.78%), the alkaloid piperine (33.79%), the monoterpene hydrocarbons 3-carene (9.53%) and limonene (6.23%), and the sesquiterpene β-caryophyllene (10.67%). Black pepper hydrodistilled oil (HDO) was also comparatively analyzed by GC–MS to

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Boonyarat, Chantana, Chavi Yenjai, Orawan Monthakantirat, et al. "Multifunctionality of Clausena harmandiana Extract and Its Active Constituents against Alzheimer’s Disease." Current Issues in Molecular Biology 44, no. 8 (2022): 3681–94. http://dx.doi.org/10.3390/cimb44080252.

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This study was designed to investigate the effects of the root-bark extract of Clausena harmandiana (CH) and its active constituents (nordentatin and 7-methoxyheptaphylline) on pharmacological activities regarding selected targets associated with AD, namely, its antioxidant activity, inhibition of Aβ aggregation, acetylcholinesterase (AChE) activity, and neuroprotective effects. The effect of the CH extract on the cognitive impairment induced by scopolamine was also evaluated in mice. The effects of the CH extract and its active constituents on radical scavenging, Aβ aggregation, and AChE acti

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Phanindhra, Bashetty, Akondi Butchi Raju, Gadiyaram Vikas, Repala Anusha, and Donapati Deepika. "Effect of Nyctanthes arbor tristis leaf extract against scopolamine-induced cognitive impairment in rats." Herba Polonica 60, no. 4 (2015): 34–49. http://dx.doi.org/10.1515/hepo-2015-0003.

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Summary Nyctanthes arbor tristis (NATE) ethanol extract (150 mg/kg, orally) was evaluated for its protective effect against scopolamine-induced (1 mg/kg i.p.) cognitive impairments in rats using behavioral models like radial arm maze test, Morris water maze test and active avoidance test. NATE effect was evaluated and compared with the standard piracetam (200mg/kg i.p.). NATE (p<0.005) significantly reversed the impairment produced by the scopolamine in radial arm maze test. In addition, NATE also decreased the time period taken to find the hidden platform in Morris water maze test and incr

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Pasala, Praveen Kumar, DSNBK Prasanth, Siva Prasad Panda, et al. "Salacia fruticosa methanol extract pretreatment attenuates scopolamine-induced cognitive decline and Alzheimer's disease-related pathology in zebrafish." Asian Pacific Journal of Tropical Biomedicine 15, no. 3 (2025): 109–18. https://doi.org/10.4103/apjtb.apjtb_642_24.

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Objective: To examine the effect of the methanolic extract of Salada fruticosa in a zebrafish model of scopolamine-induced Alzheimer’s disease. Methods: High-resolution liquid chromatography-mass spectrometry was used to characterize the phytochemical constituents of Salada fruticosa methanolic extract. The drug-likeness of these compounds was determined via the DruLiTo tool, and their acetylcholinesterase (AChE) binding affinities were studied by molecular docking. In in vivo studies, adult zebrafish were treated with 3.125, 6.25, and 12.5 mg/L of the extract for seven days and then immersed

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Nagaraju, Bandaru, A. Ramu, and S. Vidhyadhara. "Evaluation of Neuroprotective and In-vitro Anti-oxidant Activity Isolated Hexane and Ethyl Acetate Fraction from Methanolic Extract of Biophytum reinwardtii." International Journal of PharmTech Research 13, no. 2 (2020): 110–22. http://dx.doi.org/10.20902/ijptr.2019.130214.

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Nature is the best source of complementary and alternative medicine. The plant Biophytum reinwardtii has been used traditionally in pain, inflammatory and oxidative stress related disorders. In this consequence, fraction of methanolic extract of Biophytum reinwardtii was selected to explore the ability of this plant to enhance cognitive function, brain antioxidant enzymes and anti-acetyl cholinesterase activity which can be used for the treatment of oxidative stress related disorders like Alzheimer’s disease (AD). The purpose of this study was to investigate the neuroprotective effect of HEMBR

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Kmet, Оlga G., Nаtaliia D. Filipets, Taras I. Kmet, Yurii M. Vepriuk, and Kateryna V. Vlasova. "BIOCHEMICAL AND MORPHOLOGICAL MARKERS OF EXPERIMENTAL SCOPOLAMINE-INDUCED NEURODEGENERATION AND THE EFFECT OF ENALAPRIL ON THEM." Wiadomości Lekarskie 73, no. 10 (2020): 2114–19. http://dx.doi.org/10.36740/wlek202010102.

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The aim: Was to study enalapril effect on protein peroxide oxidation and lipids of the cerebral cortex and hippocampus of rats with neurodegeneration pattern. Materials and methods: The experiments were conducted on nonlinear albino male rats 0,18-0,20 kg of the body weight. Modeled neurodegeneration was simulated by intraperitoneal introduction of scopolamine hydrochloride during 27 days in the dose of 1 mg/kg. Enalapril was introduced intraperitoneal in the dose of 1 mg/kg. Results: In rats with modeled scopolamine-induced neurodegeneration in the cerebral cortex and hippocampus under enalap

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Kim, Eun Sil, Jin Bae Weon, Bo-Ra Yun, et al. "Cognitive Enhancing and Neuroprotective Effect of the Embryo of theNelumbo nuciferaSeed." Evidence-Based Complementary and Alternative Medicine 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/869831.

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The aim of the present study was to evaluate the effect of ENS on cognitive impairment induced by scopolamine and its potential neuroprotective effect against glutamate-induced cytotoxicity in HT22 cell and to investigate the underlying mechanisms. ENS (3, 10, 30, and 100 mg/kg), scopolamine (1 mg/kg), and donepezil (1 mg/kg) were administered to mice during a test period. Scopolamine impaired memory and learning in a water maze test and a passive avoidance test. The neuroprotective effect of ENS (10 and 100 μg/mL) was investigated on glutamate-induced cell death in HT22 cells by MTT assay. We

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Shagufta, Gowhar Ali, Adnan Khan, et al. "Evaluation of the Ameliorative Potential of 3,5-bis(2-hydroxyethyl)-1,3,5-thiadiazinane-2-thione against Scopolamine-Induced Alzheimer’s Disease." International Journal of Molecular Sciences 25, no. 16 (2024): 9104. http://dx.doi.org/10.3390/ijms25169104.

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Alzheimer’s disease (AD) is the most common neurodegenerative disorder, marked by cognitive impairment. Currently, the available treatment provides only symptomatic relief and there is a great need to design and formulate new drugs to stabilize AD. In the search for a new anti-Alzheimer’s drug, 3,5-bis(2-hydroxyethyl)-1,3,5-thiadiazinane-2-thione (THTT), a tetrahydro-2H-1,3,5-thiadiazine-2-thione derivative, was investigated against a scopolamine-induced Alzheimer’s model. The selected test compound was administered intraperitoneally in three doses (15 mg/kg, 30 mg/kg, and 45 mg/kg). The test

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Foyet, Harquin Simplice, Eglantine Keugong Wado, Hervé Hervé Ngatanko Abaissou, Emmanuel Acha Assongalem, and Oben Kenneth Eyong. "Anticholinesterase and Antioxidant Potential of Hydromethanolic Extract of Ziziphus mucronata (Rhamnaceae) Leaves on Scopolamine-Induced Memory and Cognitive Dysfunctions in Mice." Evidence-Based Complementary and Alternative Medicine 2019 (October 24, 2019): 1–14. http://dx.doi.org/10.1155/2019/4568401.

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Ziziphus mucronata Willd, also known as “buffalo thorn,” belongs to the family Rhamnaceae. Its bark and leaves are used in folk medicine for the treatment of various deficiencies related to nociception, inflammation, mood, and depression. Still, there is a lack of scientific data regarding its potential effect on learning and memory process. The present study was designed to investigate the neuroprotective potential of Ziziphus mucronata (ZM) on learning and memory impairment in a scopolamine-induced model of dementia in mice. The phytochemical analysis revealed five cyclopeptide alkaloids (sa

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El-Akhal, Jamila, Ioana Humulescu, Radu Ionita, et al. "Anxiolytic and Antidepressant-Like Effects of Conyza canadensis Aqueous Extract in the Scopolamine Rat Model." Plants 10, no. 4 (2021): 645. http://dx.doi.org/10.3390/plants10040645.

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Conyza canadensis is a plant widely used in traditional medicine in Morocco for the treatment of varied health challenges. However, to the best of our knowledge, there is no scientific study justifying the traditional use of Conyza extract as an anxiolytic and antidepressant agent. Moreover, data regarding the polyphenolic fraction is limited. Therefore, the present study was conducted to investigate the chemical composition of an aqueous extract obtained from the aerial parts of Conyza, its antioxidant potential, and the anxiolytic and antidepressant-like effects of the sample (100 and 200 mg

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Dwita, Lusi Putri, Fith Khaira Nursal, Supandi, et al. "The potential of kemukus (Piper cubeba L.f.) seed essential oil nanoemulsion on behavior and biochemical parameters in a rat model of scopolamine-induced Alzheimer’s disease." Pharmacia 72 (April 14, 2025): 1–11. https://doi.org/10.3897/pharmacia.72.e144711.

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Piper cubeba L.f. fruit, specifically its seeds, has been used traditionally to strengthen memory. This study aimed to examine the neuroprotective effect of a nanoemulsion of P. cubeba essential oil (NPCEO) in a scopolamine-induced rat model of Alzheimer’s disease. Male Wistar rats were divided into six groups: negative control, normal control, citicoline 200 mg/kg, NPCEO 100 mg/kg, NPCEO 200 mg/kg, and NPCEO 400 mg/kg. The brain was used for biochemical measurements, including tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-10, acetylcholinesterase (AChE) activity, brain-derived neurot

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Dwita, Lusi Putri, Fith Khaira Nursal, Supandi, et al. "The potential of kemukus (Piper cubeba L.f.) seed essential oil nanoemulsion on behavior and biochemical parameters in a rat model of scopolamine-induced Alzheimer's disease." Pharmacia 72 (April 14, 2025): 1–11. https://doi.org/10.3897/pharmacia.72.e144711.

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<i>Piper cubeba</i> L.f. fruit, specifically its seeds, has been used traditionally to strengthen memory. This study aimed to examine the neuroprotective effect of a nanoemulsion of <i>P. cubeba</i> essential oil (NPCEO) in a scopolamine-induced rat model of Alzheimer's disease. Male Wistar rats were divided into six groups: negative control, normal control, citicoline 200 mg/kg, NPCEO 100 mg/kg, NPCEO 200 mg/kg, and NPCEO 400 mg/kg. The brain was used for biochemical measurements, including tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-10, acetylcholinesterase (AChE) activity, brain-

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Chae, Ji Hyeong, Jisun Oh, Ji Sun Lim, et al. "Wasp Venom Ameliorates Scopolamine-Induced Learning and Memory Impairment in Mice." Toxins 14, no. 4 (2022): 256. http://dx.doi.org/10.3390/toxins14040256.

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This study investigated the effects of wasp venom (WV) from the yellow-legged hornet, Vespa velutina, on scopolamine (SCO)-induced memory deficits in mice, as well as the antioxidant activity in HT22 murine hippocampal neuronal cells in parallel comparison with bee venom (BV). The WV was collected from the venom sac, freeze-dried. Both venoms exhibited free radical scavenging capabilities in a concentration-dependent manner. In addition, the venom treatment enhanced cell viability at the concentrations of ≤40 µg/mL of WV and ≤4 µg/mL of BV in glutamate-treated HT22 cells, and increased the tra

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Alwaeli, Nawres Lateef, Adeeb Ahmed Al-Zubaidy, and Mariam Hadi Sadiq. "Protective effects of levosimendan in scopolamineinduced mice model of Alzheimer's disease." Romanian Journal of Neurology 23, no. 2 (2024): 171–77. http://dx.doi.org/10.37897/rjn.2024.2.14.

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Objectives. Alzheimer's disease is the most prevalent neurodegenerative disease and accounts for approximately 70% of all dementia cases worldwide. Levosimendan is a positive inotropic agent with well-documented pleiotropic properties, including anti-inflammatory and antioxidant effects. The current research evaluated the possible effect of levosimendan alone or in combination with donepezil against scopolamine-induced mice models of Alzheimer’s disease. Material and methods. Mice were divided into five groups: the control group, the induction group (scopolamine 1 mg/kg/i.p once daily for 7 da

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Woo, Yunju, Ji Sun Lim, Jisun Oh, Jeong Soon Lee, and Jong-Sang Kim. "Neuroprotective Effects of Euonymus alatus Extract on Scopolamine-Induced Memory Deficits in Mice." Antioxidants 9, no. 5 (2020): 449. http://dx.doi.org/10.3390/antiox9050449.

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Euonymus alatus is considered to elicit various beneficial effects against cancer, hyperglycemia, menstrual discomfort, diabetic complications, and detoxification. The young leaves of this plant are exploited as food and also utilized for traditional medicine in East Asian countries, including Korea and China. Our preliminary study demonstrated that ethanolic extract from the Euonymus alatus leaf (EAE) exhibited the strongest antioxidant enzyme-inducing activity among more than 100 kinds of edible tree leaf extracts. This study investigated whether EAE could attenuate the cognitive deficits ca

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Abaissou, Herve Herve Ngatanko, Foyet Harquin Simplice, Eglantine Keugong Wado, et al. "Cholinergic Enhancing and Antioxidant Effect of Vigna subterranea (L.) Verdc. (Fabaceae) Landrace Aqueous Extract on Scopolamine-Induced Amnesia in Male Swiss Mice." Revista de Chimie 70, no. 12 (2020): 4336–47. http://dx.doi.org/10.37358/rc.19.12.7755.

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The present study was conducted to investigate protective effects of the aqueous extract of V. subterranea seeds landrace on amnesia induced by scopolamine in mice. V. subterranea aqueous extract (100, 200 and 400 mg/kg BW) was administered by gavage for nine consecutive days and memory impairment was induced by repeated intraperitoneal injection of scopolamine (1.5 mg/kg). The Y-maze (YM), Morris water maze (MWM), novel object recognition paradigm (NOR) and the T maze (TM) were used to assess learning, memory and retention. Superoxide dismutase (SOD), Catalase (CAT), Malondialdehyde (MDA) lev

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Abdelmonem, M., A. Hemdan, D. Ghareeb, M. El demellawy, H. Wasim, and M. El sayed. "Evaluating Antioxidant Enzyme Parameters in Rats Treated with Berberine-Loaded Bovine Serum Albumin Nanoparticles and Scopolamine." American Journal of Clinical Pathology 162, Supplement_1 (2024): S22—S23. http://dx.doi.org/10.1093/ajcp/aqae129.049.

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Abstract Introduction/Objective Introduction: Berberine (BER) has garnered attention for its antioxidant properties demonstrated in various studies, showing its ability to scavenge or inhibit reactive oxygen species (ROS) and reactive nitrogen species (RNS), including nitric oxide, superoxide anion, and peroxynitrites. Methods/Case Report Methods: Forty-two male Wistar rats were randomly assigned to seven groups, each comprising 6 rats: Sham control (no treatment), BSA-NPs orally administered, BRB-NPs orally administered, SCO intraperitoneally injected, BER followed by SCO injection, BSA-NPs w

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Kim, Min-Jeong, Eun-Sang Hwang, Kwan Joong Kim, et al. "Anti-Amnesic Effects of Epigallocatechin Gallate on Scopolamine-Induced Learning and Memory Dysfunction in Sprague-Dawley Rats." Antioxidants 11, no. 1 (2021): 1. http://dx.doi.org/10.3390/antiox11010001.

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Epigallocatechin gallate (EGCG) is a major flavan-3-ol of green tea polyphenols that exhibits various beneficial health effects, including antioxidant, anti-bacterial, and anti-inflammatory properties. This study aimed to evaluate whether EGCG prevents scopolamine-induced learning and memory impairment in in vivo and ex vivo models. Male Sprague-Dawley (SD) rats were pre-treated with EGCG (5 mg/kg/day; intraperitoneal injection (i.p.)) for 10 days. Then, EGCG and scopolamine (1 mg/kg/day; i.p.) were applied 60 and 30 min before the behavioral tests, respectively, for another 9 days. EGCG allev

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Lee, Hyeon Yong, Jin Bae Weon, Youn Sik Jung, Nam Young Kim, Myong Ki Kim, and Choong Je Ma. "Cognitive-Enhancing Effect ofAronia melanocarpaExtract against Memory Impairment Induced by Scopolamine in Mice." Evidence-Based Complementary and Alternative Medicine 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/6145926.

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Aronia melanocarpa(A. melanocarpa)berriesare a fruit with a marked antioxidant effect. The objective of this study was to confirm the effect ofA. melanocarpa berriesextract against scopolamine-induced memory impairment in mice using the Morris water maze and passive avoidance test. Moreover, we determined a possible mechanism of the cognitive-enhancing effect involving AChE activity and BDNF and p-CREB expression in the hippocampus of mice.A. melanocarpa berriesextract attenuated the learning and memory impairment induced by scopolamine in the Morris water maze (79.3 ± 0.8 s of 200 mg/kg and 6

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Assaran, Amir Hossein, Mahmoud Hosseini, Matin Shirazinia та ін. "Neuro-protective Effect of Acetyl-11-keto-β-boswellic Acid in a Rat Model of Scopolamine-induced Cholinergic Dysfunction". Current Pharmaceutical Design 30, № 2 (2024): 140–50. http://dx.doi.org/10.2174/0113816128269289231226115446.

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Background:: Acetyl-11-keto-β-boswellic acid (AKBA) is a major component of the oleo-gum resin of B. serrata with multiple pharmacological activities. The objective of this study was to explore the underlying mechanisms of neuroprotective potential of AKBA against scopolamine-mediated cholinergic dysfunction and memory deficits in rats. Methods:: The rats received AKBA (2.5, 5, and 10 mg/kg, oral) for 21 days. In the third week, scopolamine was administered 30 min before the Morris water maze and passive avoidance tests. In order to perform biochemical assessments, the hippocampus and prefront

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Lu, Hongyan, Li Fang, Ji Wang, et al. "Pine nut antioxidant peptides ameliorate the memory impairment in a scopolamine-induced mouse model via SIRT3-induced synaptic plasticity." Food & Function 12, no. 17 (2021): 8026–36. http://dx.doi.org/10.1039/d1fo01817e.

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The effects of a pine nut albumin hydrolysate (fraction <3 kDa) and Trp-Tyr-Pro-Gly-Lys (WYPGK) on synaptic plasticity and memory function in scopolamine-induced memory-impaired mice, as well as the potential underlying mechanism in PC12 cells.

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Sandrine, Mengue Ngadena Yolande, Kavaye Kandeda Antoine, Bilanda Danielle Claude, et al. "Bridelia atroviridis (Phyllanthaceae) Aqueous Extract Attenuates Scopolamine-induced Amnesia and Depression in Rat: Role of Cholinergic, Monoaminergic, and Antioxidant Mechanisms." Asian Journal of Research in Medical and Pharmaceutical Sciences 12, no. 3 (2023): 82–100. http://dx.doi.org/10.9734/ajrimps/2023/v12i3224.

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Background: Anti-inflammatory and antioxidant activities are the main pathways of neuroprotective drugs. Bridelia atroviridis possesses those activities and is empirically used by Cameroonian traditional healers to alleviate memory and mood disorders. Objective: The purpose of this study is to evaluate the anti-amnesic and antidepressant effects of Bridelia atroviridis aqueous extract (EA). Methods: Scopolamine was used to induce amnesia and depression in rats. Administrated per os, three doses of EA, including 36, 72, and 144 mg/kg, were used. Behavioral disorders were evaluated t

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Kaur, Awaneet, Md Aftab Alam, Tarique Mahmood, and Farogh Ahsan. "Probing the Memory-Enhancing Potential of Kiwi Fruit Against Scopolamine-Induced Memory Impairment in Experimental Rats." Biomedical and Pharmacology Journal 17, no. 2 (2024): 1165–76. http://dx.doi.org/10.13005/bpj/2931.

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It is good knowledge that the nutrient-dense kiwi fruit promotes better overall health. The antioxidant properties of kiwifruit have attracted attention as a possible reason for the fruit's health-enhancing effects. In comparison to chemical antioxidant assays, this study of the antioxidant capacity of kiwifruit discusses biologically relevant in vitro assays for predicting antioxidant activity in a biological location. These assays can be performed in a laboratory setting. The topic of discussion pertains to the potential of kiwifruit to serve as a cytoprotective agent against hydrogen peroxi

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Al-Amin, Md Yusuf, Amitav Lahiry, Rafia Ferdous, et al. "Stephania japonica Ameliorates Scopolamine-Induced Memory Impairment in Mice through Inhibition of Acetylcholinesterase and Oxidative Stress." Advances in Pharmacological and Pharmaceutical Sciences 2022 (February 21, 2022): 1–17. http://dx.doi.org/10.1155/2022/8305271.

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Alzheimer’s disease (AD) is a progressive neurological disorder characterized by loss of memory and cognition. Stephania japonica is being used as traditional medicine in the treatment of different neurological problems. In this study, we evaluated the anticholinesterase and antioxidant activities of the crude methanol extract of S. japonica and its fractions in vitro and the neuroprotective effect of the most active fraction in the scopolamine-induced mouse model of memory impairment. Among the crude extract and its fractions, chloroform fraction exerted strong inhibition of acetylcholinester

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Eshaghi Ghalibaf, Mohammad Hosein, Arezoo Rajabian, Mohsen Parviz, et al. "Minocycline alleviated scopolamine-induced amnesia by regulating antioxidant and cholinergic function." Heliyon 9, no. 2 (2023): e13452. http://dx.doi.org/10.1016/j.heliyon.2023.e13452.

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Kong, Hyun-Joo, Kyung-Eun Lee, and Kyung-Mi Yang. "Antioxidant Effect of Chungkukjang Supplementation against Memory Impairment induced by Scopolamine in Mice." Journal of the East Asian Society of Dietary Life 26, no. 3 (2016): 237–49. http://dx.doi.org/10.17495/easdl.2016.6.26.3.237.

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Fava de Souza, Maiara, Jéssica Maurino dos Santos, Sidney Mariano dos Santos, et al. "Duguetia furfuracea (A.ST. Hil.) Saff.: Neuroprotective Effect on Chemically Induced Amnesia, Anxiolytic Effects and Preclinical Safety Evaluation in Mice." Biology 13, no. 12 (2024): 981. http://dx.doi.org/10.3390/biology13120981.

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Duguetia furfuracea, “araticum-seco”, is known to contain several bioactive compounds that can mitigate oxidative stress and act on the central nervous system (CNS). This effect is partly attributed to its potent antioxidant and acetylcholinesterase (AChE) inhibitors. In this study, the effects were explored of the methanolic extract (MEDF) and alkaloid fraction (AFDF) of D. furfuracea (leaves) on cognitive behaviors in male mice with scopolamine (Scop)-induced cognitive impairment and biochemical parameters. Additionally, anxiolytic behavior, subacute toxicity, molecular docking and antioxida

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Doreddula, Sathish Kumar, Srinivasa Reddy Bonam, Durga Prasad Gaddam, Brahma Srinivasa Rao Desu, Nadendla Ramarao, and Vijayapandi Pandy. "Phytochemical Analysis, Antioxidant, Antistress, and Nootropic Activities of Aqueous and Methanolic Seed Extracts of Ladies Finger (Abelmoschus esculentusL.) in Mice." Scientific World Journal 2014 (2014): 1–14. http://dx.doi.org/10.1155/2014/519848.

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Abelmoschus esculentusL. (ladies finger, okra) is a well-known tropical vegetable, widely planted from Africa to Asia and from South Europe to America. In the present study, we investigated thein vitroantioxidant capacity andin vivoprotective effect of the aqueous and methanolic seed extracts ofAbelmoschus esculentusagainst scopolamine-induced cognitive impairment using passive avoidance task and acute restraining stress-induced behavioural and biochemical changes using elevated plus maze (EPM) and forced swimming test (FST) in mice. Our results demonstrated that the pretreatment of mice with

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Lee, Na-Kyoung, Yunjung Lee, Minhye Won, Nayeong Kim, Eunju Park, and Hyun-Dong Paik. "Preventive Effect of Probiotic Leuconostoc mesenteroides H40 Against Cognitive Disorder by Anti-Inflammatory, Synaptic Plasticity Regulation, and Antioxidant Effects." Antioxidants 14, no. 5 (2025): 565. https://doi.org/10.3390/antiox14050565.

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Live Leuconostoc mesenteroides H40 has been reported to have probiotic properties; however, the effect of its live probiotic form on cognitive ability has not been reported. This study investigated modulatory effects of the probiotic L. mesenteroides H40 in an ICR mouse model (male) of cognitive disorders. Cognitive disorders were induced in mice by the addition of scopolamine (1 mg/kg/day) with donepezil (2 mg/kg/day) as a medicinal control. L. mesenteroides H40 significantly attenuated scopolamine-induced cognitive disorder in the novel object recognition and Y-maze tests in a concentration-

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Lee, Gil-Yong, Chan Lee, Gyu Hwan Park та Jung-Hee Jang. "Amelioration of Scopolamine-Induced Learning and Memory Impairment byα-Pinene in C57BL/6 Mice". Evidence-Based Complementary and Alternative Medicine 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/4926815.

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Increasing evidence suggests that neurodegenerative disorders such as Alzheimer’s disease (AD) are mediated via disruption of cholinergic neurons and enhanced oxidative stress. Therefore, attention has been focused on searching for antioxidant phytochemicals for the prevention and/or treatment of AD through their ability to fortify cholinergic function and antioxidant defense capacity. In this study, we have investigated the neuroprotective effect ofα-pinene (APN) against learning and memory impairment induced by scopolamine (SCO, 1 mg/kg, i.p.), a muscarinic receptor antagonist in C57BL/6 mic

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Valu, Mihai-Vlad, Liliana Cristina Soare, Catalin Ducu, et al. "Hericium erinaceus (Bull.) Pers. Ethanolic Extract with Antioxidant Properties on Scopolamine-Induced Memory Deficits in a Zebrafish Model of Cognitive Impairment." Journal of Fungi 7, no. 6 (2021): 477. http://dx.doi.org/10.3390/jof7060477.

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Hericium erinaceus (H. erinaceus) is a rare and appreciated fungal species belonging to the division Basidiomycota used for centuries in traditional Chinese medicine for its medicinal value. This species of mushrooms brings the most diverse benefits for the human body, and can have beneficial effects for treating Alzheimer's disease (AD). This study investigated whether ethanolic extract from the fungal biomass of H. erinaceus enhances cognitive function via the action on cholinergic neurons using the scopolamine (SCOP)-induced zebrafish (Danio rerio) model of memory impairment. The ethanolic

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Jawaid, Talha, Ashok K. Shakya, Hefazat Hussain Siddiqui, and Mehnaz Kamal. "Evaluation of Cucurbita maxima Extract against Scopolamine- Induced Amnesia in Rats: Implication of Tumour Necrosis Factor Alpha." Zeitschrift für Naturforschung C 69, no. 9-10 (2014): 407–17. http://dx.doi.org/10.5560/znc.2014-0003.

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AbstractCucurbita maxima (CM) seed oil is commonly used in Indian folk medicine to treat various ailments. We have investigated the effect of CM seed oil on memory impairment induced by scopolamine in rats. Male adult Wistar rats were administered scopolamine 1 mg/kg body weight, i.p. or 1:25 mg/kg body weight, s.c. to induce memory impairment. The nootropic agent piracetam 100 mg/kg body weight, i.p. and CM seed oil 100 and 200 mg/kg body weight, p.o. were administered daily for five consecutive days. The memory function was evaluated in the Morris water maze (MWM) test, the social recognitio

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